CN104825392A - Processing system and method for reducing peroxide value and anisidine value of fat emulsion - Google Patents

Processing system and method for reducing peroxide value and anisidine value of fat emulsion Download PDF

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CN104825392A
CN104825392A CN201510198910.XA CN201510198910A CN104825392A CN 104825392 A CN104825392 A CN 104825392A CN 201510198910 A CN201510198910 A CN 201510198910A CN 104825392 A CN104825392 A CN 104825392A
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tank
communicated
homogenizing
fat milk
pipeline
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CN104825392B (en
Inventor
邓茂林
王云川
何颖
谭鸿波
刘思川
程志鹏
葛均友
万阳浴
刘文军
罗成鑫
吴小愚
陈柯志
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Sichuan Kelun Pharmaceutical Co Ltd
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Sichuan Kelun Pharmaceutical Co Ltd
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Abstract

The invention discloses a treatment system for reducing the peroxide value and the anisidine value of fat emulsion, which comprises a deaerator (1), a homogenizer (5), a homogenizing pump (6), a configuration tank, a filling machine (8) and a nitrogen conveying pipe (9), wherein the nitrogen conveying pipe (9) is respectively communicated with the configuration tanks, the deaerator (1) is respectively communicated with a glycerin tank (2) and a primary emulsion tank (3) through pipelines, the primary emulsion tank (3), the homogenizer (5), the homogenizing pump (6) and the homogenizing tank (4) form a closed circulation automatic control system through pipelines, the homogenizing tank (4) is communicated with a filling tank (7), the filling tank (7) is communicated with a filling machine (8), a plurality of vacuumizing devices are arranged below the filling machine (8), and the treatment system also discloses a method for reducing the peroxide value and the anisidine value of the fat emulsion. The invention has the beneficial effects that: it has the advantages of improving the quality of fat milk, prolonging the storage time of the fat milk and reducing the peroxide value and the anisidine value of the fat milk.

Description

Reduce fat milk peroxide value and anisidine value processing system and method thereof
Technical field
The present invention relates to fat milk preparation field, particularly reduce fat milk peroxide value and anisidine value processing system and method thereof.
Background technology
Fat milk is a kind of not only even but also stable lipomul be made up of refined soybean oil, glycerol, lecithin etc., provides high-energy and required fatty acid under the importance that its is treated is non-bowel provisions.Proved that the fat that human body is taken in first forms Chylomicron through gastrointestinal absorption from physiology and threpsology, and the form of these product is all extremely similar to chyle with composition, directly to the venous patient infusion that can not take food, can provide lipid nutrition.
But, lipomul peroxide value aborning and anisidine value compare and are difficult to control, directly affect product quality and quality, thus jeopardize user health of human body, therefore for ensureing the quality of lipomul, ensure the health of human body of user, the lipomul that peroxide value and anisidine value are all lower must be used.
Summary of the invention
The object of the invention is to the shortcoming overcoming prior art, provide a kind of and improve product quality, the processing system that can reduce fat milk peroxide value and anisidine value and method thereof.
Object of the present invention is achieved through the following technical solutions: reduce fat milk peroxide value and anisidine value processing system, it comprises oxygen-eliminating device, glycerol tank, colostrum tank, homogenizing tank, homogenizer, Homogenizing pump, fill tank, filling machine and nitrogen carrier pipe, described nitrogen carrier pipe respectively with glycerol tank, colostrum tank, homogenizing tank, fill tank is communicated with filling machine, the bypass line that it is communicated with is provided with valve, and described oxygen-eliminating device is communicated with colostrum tank with glycerol tank respectively by pipeline, and described glycerol tank and colostrum tank pass through pipeline communication, and on its pipeline, be provided with bivalve, described colostrum tank, homogenizer, Homogenizing pump and homogenizing tank form closed circulation robot control system(RCS) by pipeline, described homogenizing tank is communicated with fill tank, and bivalve is provided with on its pipeline be communicated with, fill tank is communicated with can packing machine, and bivalve is provided with on its pipeline be communicated with, be provided with multiple vacuum extractor below described filling machine, the front end of vacuum extractor is provided with valve.
Described closed cycle system is made up of a homogenisation cycle system and second homogenate blood circulation, wherein in a homogenisation cycle system, the port of export of colostrum tank is communicated with the entrance point of Homogenizing pump, and bivalve is provided with on its pipeline be communicated with, the port of export of Homogenizing pump is communicated with homogenizer, the port of export of described homogenizer is communicated with fill tank, and the pipeline that it is communicated with is provided with bivalve; In second homogenate blood circulation, the bottom of homogenizing tank is communicated with the entrance point of Homogenizing pump, and is provided with bivalve on its pipeline be communicated with, and the port of export of Homogenizing pump is communicated with homogenizer, the port of export of described homogenizer is communicated with colostrum tank, and the pipeline that it is communicated with is provided with bivalve.
Described filling machine lower end arranges three vacuum extractors.
Described glycerol tank and the tank connected pipeline of colostrum are provided with a delivery pump and filter.
Reduce the method for fat milk peroxide value and anisidine value, it comprises following steps:
S1: source deoxygenation, water for injection is directly connected with oxygen-eliminating device by pipeline, reduces the content of injection water oxygen, obtains the water for injection that oxygen content is lower;
S2: isotonic process, is transported to water for injection in S1 in glycerol tank, makes water for injection and glycerol according to the ratio mixing of regulation, is then sent in colostrum tank by the medicinal liquid mixed, obtain fat milk;
S3; Homogenizing process, fat milk in being filled with by colostrum is through a homogenisation cycle system homogenizing, then be stored in homogenizing tank, again by the fat milk in homogenizing tank through second homogenate blood circulation homogenizing, again get back in colostrum tank, repeatedly repeat above-mentioned action, reach the object that fat milk emulsifying reduces anisidine value, then by the fat milk that homogenizing is good, be transported in fill tank by Homogenizing pump;
S4: fill process: the fat milk in fill tank, by nitrogen pressure press-in filling machine, then through multiple vacuum extractor repeatedly evacuation, repeatedly nitrogen filled protection, realizes the low oxygen and filling nitrogen fill of fat milk;
Described step S2, S3 and S4 all implement under the protection of nitrogen
The present invention has the following advantages: the present invention arranges oxygen-eliminating device in the source of preparation water, reach the object of alternate source head processed deoxygenation, and in lipomul production process, under being all in the protective effect of nitrogen, the contact of isolated lipomul and extraneous oxygen, reduces the peroxide value in lipomul; In fat milk preparation process, fat milk repeatedly enters homogenizing in homogenizer by blood circulation, reduces the anisidine value in fat milk; And in fat milk pouring process, repeatedly evacuation and fill nitrogen, further ensure that fat milk does not contact with extraneous oxygen, makes the oxygen content of fat milk on the low side, extend the storage time of fat milk, improve the quality of fat milk.
Accompanying drawing explanation
Fig. 1 is the device schematic flow sheet of the embodiment of the present invention;
In figure, 1-oxygen-eliminating device, 2-glycerol tank, 3-colostrum tank, 4-homogenizing tank, 5-homogenizer, 6-Homogenizing pump, 7-fill tank, 8-filling machine, 9-nitrogen carrier pipe.
Detailed description of the invention
Below in conjunction with accompanying drawing, the present invention will be further described, and protection scope of the present invention is not limited to the following stated:
As shown in Figure 1, reduce fat milk peroxide value and anisidine value processing system, it comprises oxygen-eliminating device 1, glycerol tank 2, colostrum tank 3, homogenizing tank 4, homogenizer 5, Homogenizing pump 6, fill tank 7, filling machine 8 and nitrogen carrier pipe 9, described nitrogen carrier pipe 9 respectively with glycerol tank 2, colostrum tank 3, homogenizing tank 4, fill tank 7 is communicated with filling machine 8, the bypass line that it is communicated with is provided with valve, valve is in normally open herein, whole lipomul is all in nitrogen protection in preparation process, isolated lipomul, glycerol tank 2, colostrum tank 3, homogenizing tank 4, fill tank 7 contacts with extraneous oxygen with filling machine 8, thus the peroxide value reduced in fat milk, and make its content maintain in a less interval all the time, described oxygen-eliminating device 1 is communicated with colostrum tank 3 with glycerol tank 2 respectively by pipeline, water for injection is through oxygen-eliminating device 1 deoxygenation, thus described glycerol tank 2 passes through pipeline communication with colostrum tank 3, and bivalve is provided with on its pipeline, the water for injection that configuration emulsion products uses, all deoxygenation process has been carried out enter glycerol tank 2 and colostrum tank 3 after oxygen-eliminating device 1 deoxygenation before, reach the dissolved oxygen amount that Sources controlling prepares use water, described colostrum tank 3, homogenizer 5, Homogenizing pump 6 and homogenizing tank 4 form closed circulation robot control system(RCS) by pipeline, described homogenizing tank 4 is communicated with fill tank 7, and bivalve is provided with on its pipeline be communicated with, fill tank 7 is communicated with can packing machine 8, and bivalve is provided with on its pipeline be communicated with, lipomul in fill tank 7 is pushed down in filling machine 8 in the effect of nitrogen pressure, multiple vacuum extractor is provided with below described filling machine 8, the front end of vacuum extractor is provided with valve, in the present embodiment, described filling machine 8 lower end arranges three vacuum extractors, vacuum extractor, regulate vacuum extractor can carry out three evacuation and three nitrogen filled protections to the lipomul of fill, and can according to practical situation, at each evacuation with when filling nitrogen, can one by one to single evacuation amount and the parameter adjustment of filling nitrogen quantity, ensure the existence of medicinal liquid bottle noresidue oxygen.
In this enforcement, described closed cycle system is made up of a homogenisation cycle system and second homogenate blood circulation, wherein in a homogenisation cycle system, the port of export of colostrum tank 3 is communicated with the entrance point of Homogenizing pump 6, and bivalve is provided with on its pipeline be communicated with, the port of export of Homogenizing pump 6 is communicated with homogenizer 5, the port of export of described homogenizer 5 is communicated with fill tank 7, the pipeline that it is communicated with is provided with bivalve, fat milk in colostrum tank 3 delivers in homogenizer 5 through Homogenizing pump 6, fat milk enters in homogenizing tank 4 and stores after the anisidine value that homogenizer 5 reduces fat milk, after the fat milk in colostrum tank 3 drains, close and open corresponding valve, fat milk is made to enter in second homogenate blood circulation, in second homogenate blood circulation, the bottom of homogenizing tank 4 is communicated with the entrance point of Homogenizing pump 6, and bivalve is provided with on its pipeline be communicated with, the port of export of Homogenizing pump 6 is communicated with homogenizer 5, the port of export of described homogenizer 5 is communicated with colostrum tank 3, the pipeline that it is communicated with is provided with bivalve, fat milk in homogenizing tank 4 is transported in homogenizer through Homogenizing pump 6, fat milk enters in colostrum tank 4 and stores after the anisidine value that homogenizer 5 reduces fat milk again, after the fat milk in homogenizing tank 4 drains, close and open corresponding valve, fat milk is made to enter in a homogenisation cycle system, repeatedly repeat above-mentioned action, anisidine value in fat milk is significantly reduced.
In the present embodiment, the pipeline that described glycerol tank 2 is connected with colostrum tank 3 is provided with a delivery pump and filter, and do not indicate in the drawings, medicinal liquid enters into colostrum tank 3 by delivery pump and metre filter.
In the present embodiment, the pipeline be communicated with arranges bivalve, can valves leakage be prevented, improve safety coefficient, be also provided with blow-off pipe in the bottom of glycerol tank 2, colostrum tank 3, homogenizing tank 4, fill tank 7, blow-off pipe be provided with valve, do not indicate in figure.
Described reduction fat milk peroxide value and the method for anisidine value, it comprises following steps:
S1: source deoxygenation, water for injection is directly connected with oxygen-eliminating device 1 by pipeline, reaches the dissolved oxygen amount that Sources controlling prepares use water, reduces the content of injection water oxygen, obtains the water for injection that oxygen content is lower;
S2: isotonic process, is transported to water for injection in S1 in glycerol tank 2, makes water for injection and glycerol according to the ratio mixing of regulation, is then sent in colostrum tank 3 by the medicinal liquid mixed, obtain fat milk;
S3; Emulsifying, by the fat milk in colostrum filling 3 through a homogenisation cycle system homogenizing, then be stored in homogenizing tank 4, again by the fat milk in homogenizing tank 4 through second homogenate blood circulation homogenizing, again get back in colostrum tank 3, repeatedly repeat above-mentioned action, reach the object that fat milk emulsifying reduces anisidine value, then by the fat milk that homogenizing is good, be transported in fill tank 7 by Homogenizing pump 6;
S4: fill process: the fat milk in fill tank 7 is by nitrogen pressure press-in filling machine 8, completely cut off the contact with extraneous oxygen, and then through filling machine 8 fill in medicinal liquid bottle, filling machine possesses carrying out evacuation to product splendid attire medicinal liquid bottle and filling nitrogen of three discontinuity, the parameter adjustment of single splendid attire medicinal liquid bottle vacuum and nitrogen amount size can be implemented, to ensure the existence of medicinal liquid bottle noresidue oxygen.
Implement under protection all at nitrogen of described step S2, S3 and S4; thus reach source deoxygenation; in emulsifying and pouring process; completely cut off the contact with extraneous oxygen; play the object reducing fat milk peroxide value; and fat milk is through repeatedly emulsifying, make the anisidine value content in fat milk less, serve the effect reducing anisidine value.

Claims (5)

1. reduce fat milk peroxide value and anisidine value processing system, it is characterized in that: it comprises oxygen-eliminating device (1), glycerol tank (2), colostrum tank (3), homogenizing tank (4), homogenizer (5), Homogenizing pump (6), fill tank (7), filling machine (8) and nitrogen carrier pipe (9), described nitrogen carrier pipe (9) respectively with glycerol tank (2), colostrum tank (3), homogenizing tank (4), fill tank (7) is communicated with filling machine (8), the bypass line that it is communicated with is provided with valve, described oxygen-eliminating device (1) is communicated with colostrum tank (3) with glycerol tank (2) respectively by pipeline, described glycerol tank (2) and colostrum tank (3) pass through pipeline communication, and on its pipeline, be provided with bivalve, described colostrum tank (3), homogenizer (5), Homogenizing pump (6) and homogenizing tank (4) form closed circulation robot control system(RCS) by pipeline, described homogenizing tank (4) is communicated with fill tank (7), and bivalve is provided with on its pipeline be communicated with, fill tank (7) is communicated with can packing machine (8), and bivalve is provided with on its pipeline be communicated with, described filling machine (8) below is provided with multiple vacuum extractor, and the front end of vacuum extractor is provided with valve.
2. reduction fat milk peroxide value according to claim 1 and anisidine value processing system, it is characterized in that: described closed cycle system is made up of a homogenisation cycle system and second homogenate blood circulation, wherein in a homogenisation cycle system, the port of export of colostrum tank (3) is communicated with the entrance point of Homogenizing pump () 6, and bivalve is provided with on its pipeline be communicated with, the port of export of Homogenizing pump (6) is communicated with homogenizer (5), the port of export of described homogenizer (5) is communicated with fill tank (7), and the pipeline that it is communicated with is provided with bivalve; In second homogenate blood circulation, the bottom of homogenizing tank (4) is communicated with the entrance point of Homogenizing pump (6), and bivalve is provided with on its pipeline be communicated with, the port of export of Homogenizing pump (6) is communicated with homogenizer (5), the port of export of described homogenizer (5) is communicated with colostrum tank (3), and the pipeline that it is communicated with is provided with bivalve.
3. reduction fat milk peroxide value according to claim 1 and anisidine value processing system, is characterized in that: described filling machine (8) lower end arranges three vacuum extractors.
4. reduction fat milk peroxide value according to claim 1 and anisidine value processing system, is characterized in that: the pipeline that described glycerol tank (2) is connected with colostrum tank (3) is provided with a delivery pump and filter.
5., based on the method for the reduction fat milk peroxide value described in any one of claim 1 ~ 4 and anisidine value, it is characterized in that: it comprises following steps:
S1: source deoxygenation, water for injection is directly connected with oxygen-eliminating device (1) by pipeline, reduces the content of injection water oxygen, obtains the water for injection that oxygen content is lower;
S2: isotonic process, is transported to water for injection in S1 in glycerol tank (2), makes water for injection and glycerol according to the ratio mixing of regulation, is then sent in colostrum tank (3) by the medicinal liquid mixed, obtain fat milk;
S3; Homogenizing process, by the fat milk in colostrum filling (3) through a homogenisation cycle system homogenizing, then be stored in homogenizing tank (4), again by the fat milk in homogenizing tank (4) through second homogenate blood circulation homogenizing, again get back in colostrum tank (3), repeatedly repeat above-mentioned action, reach the object that fat milk emulsifying reduces anisidine value, then by the fat milk that homogenizing is good, be transported in fill tank by Homogenizing pump (6);
S4: fill process: the fat milk in fill tank (7) is pressed in filling machine (8) by nitrogen pressure, then through multiple vacuum extractor repeatedly evacuation, repeatedly nitrogen filled protection, realizes the low oxygen and filling nitrogen fill of fat milk;
The method of reduction fat milk peroxide value according to claim 5 and anisidine value, is characterized in that: described step S2, S3 and S4 all implement under the protection of nitrogen.
CN201510198910.XA 2015-04-24 2015-04-24 Processing system and method for reducing peroxide value and anisidine value of fat emulsion Active CN104825392B (en)

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Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105950285A (en) * 2016-04-21 2016-09-21 内蒙古蒙牛乳业(集团)股份有限公司 Extraction method for fat in dairy product and determination method for peroxide value of fat
CN106074672A (en) * 2016-07-18 2016-11-09 四川科伦药业股份有限公司 Constant temperature system for improving quality of fat milk product
CN106490656A (en) * 2016-12-13 2017-03-15 厦门惠盈动物科技有限公司 A kind of emulsification liquid additive premix production system and production technology
CN106881049A (en) * 2015-12-15 2017-06-23 上海奥星制药技术装备有限公司 Homogeneous control system and its control method
CN114948871A (en) * 2022-06-14 2022-08-30 四川科伦药业股份有限公司 Fat emulsion injection and preparation method and device thereof

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CN101836956A (en) * 2010-05-31 2010-09-22 青岛华仁药业股份有限公司 Preparation process of fat emulsion injection products and fat emulsion injection products
CN102188374A (en) * 2010-12-29 2011-09-21 山东鲁抗辰欣药业有限公司 Medium/long fat emulsion injection and preparation method thereof
CN204050374U (en) * 2014-08-29 2014-12-31 四川科伦药业股份有限公司 A kind of fat milk tail washings blood processor

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2143815C1 (en) * 1998-11-23 2000-01-10 ОАО "Незлобненский комбинат хлебопродуктов" Apparatus for producing soya food emulsion
CN101836956A (en) * 2010-05-31 2010-09-22 青岛华仁药业股份有限公司 Preparation process of fat emulsion injection products and fat emulsion injection products
CN102188374A (en) * 2010-12-29 2011-09-21 山东鲁抗辰欣药业有限公司 Medium/long fat emulsion injection and preparation method thereof
CN204050374U (en) * 2014-08-29 2014-12-31 四川科伦药业股份有限公司 A kind of fat milk tail washings blood processor

Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN106881049A (en) * 2015-12-15 2017-06-23 上海奥星制药技术装备有限公司 Homogeneous control system and its control method
CN105950285A (en) * 2016-04-21 2016-09-21 内蒙古蒙牛乳业(集团)股份有限公司 Extraction method for fat in dairy product and determination method for peroxide value of fat
CN106074672A (en) * 2016-07-18 2016-11-09 四川科伦药业股份有限公司 Constant temperature system for improving quality of fat milk product
CN106074672B (en) * 2016-07-18 2021-10-29 四川科伦药业股份有限公司 Constant temperature system for improving quality of fat milk product
CN106490656A (en) * 2016-12-13 2017-03-15 厦门惠盈动物科技有限公司 A kind of emulsification liquid additive premix production system and production technology
CN114948871A (en) * 2022-06-14 2022-08-30 四川科伦药业股份有限公司 Fat emulsion injection and preparation method and device thereof
CN114948871B (en) * 2022-06-14 2023-11-17 四川科伦药业股份有限公司 Fat emulsion injection and preparation method and device thereof

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