CN104815024A - Capsule for treating gout and preparation method thereof - Google Patents

Abstract

The invention discloses a method for preparing a capsule for treating gout. The method comprises the following steps: a, smashing the following raw materials in parts by weight: hylotelephium telephium, Campsis grandiflora Loisel, photinia root, inonotus obliquus, Korthalsella japonica, Anredera cordifolia, Selaginella uncinata, and Lysimachia christinae Hance, mixing, adding purified water according to the material/liquid ratio of 1:8, carrying out reflux extracting for 3 times, 2h each time, and mixing the return fluid; condensing to get the extractum with the relative density of 1.20-1.35 at the temperature of 35 DEG C; b, adding chondroitin sulfate powder in parts by weight into the extractum prepared in the step a, mixing uniformly, drying and filling the capsules with the mixture. Each capsule is filled with 0.45g of the medicine, 2-4 capsules are taken each time, and 2-3 times a day. All medicines are matched to achieve the functions of activating blood, dredging collaterals, tonifying the liver and kidneys, dispelling wind and alleviating pain; the synergistic effect of all the medicine components is prominent; the toxic side effect on the liver and the kidneys is smaller than that of the Western medicine; the capsule has obvious treatment effect on the gout.

Description

A kind of capsule for the treatment of gout and preparation method thereof

Technical field

The invention belongs to field of medicaments, be specially a kind of capsule for the treatment of gout and preparation method thereof.

Background technology

Gout is the crystal dependency arthrosis caused by monosodium urate salt (MSU) deposits, directly related with the hyperuricemia caused by purine metabolic disturbance and (or) underexcretion, refer in particular to acute characteristic arthritis and chronic gout stone disease, mainly comprising acute attack arthritis, tophus formation, tophaceous chronic arthritis, urate nephropathy and uric acid lithangiuria, can there is joint deformity and renal insufficiency in severe one.Gout often accompanies the performances such as abdominal obesity, hyperlipemia, hypertension, type 2 diabetes mellitus and cardiovascular diseases.

The treatment of gout comprises the anti-inflammatory analgesic (NSAIDs is first-selected) of acute stage and the treatment of paracmastic uric acid resisting.Should according to renal function of patients situation, with or without concrete medications of selection such as renal calculuss.Uric acid resisting drug main will comprise and suppresses uricopoiesis class (allopurinol) and promote urate excretion class (benzbromarone).Usually select headed by the latter.Colchicine is the conventional medicament for the treatment of acute attack.Colchicine untoward reaction is more, mainly gastrointestinal reaction, also can cause bone marrow depression, hepatic injury, allergy and neurotoxicity etc.Untoward reaction is relevant to dosage, and renal insufficiency person answers decrement to use.

Summary of the invention

The object of this invention is to provide a kind of capsule for the treatment of gout and preparation method thereof.

The present invention treats the capsule of gout; Be made up of the crude drug of following parts by weight: purple Hylotelephium erythrostictum (Miq.) H.Ohba 23 ~ 25 parts, Radix campsis 18 ~ 20 parts, Briar 15 ~ 18 parts, Inonqqus obliquus 23 ~ 25 parts, Li Jisheng 18 ~ 20 parts, Bulbilus boussingaultiae pseudobaselloidis 15 ~ 17 parts, CUIYUNCAO 20 ~ 23 parts, Herba Lysimachiae 13 ~ 16 parts, chondroitin sulfate 10 ~ 13 parts.

As optimization, the capsule of this treatment gout, is made up of the crude drug of following parts by weight: purple Hylotelephium erythrostictum (Miq.) H.Ohba 24 parts, Radix campsis 19 parts, Briar 16 parts, Inonqqus obliquus 24 parts, Li Jisheng 19 parts, Bulbilus boussingaultiae pseudobaselloidis 16 parts, CUIYUNCAO 22 parts, Herba Lysimachiae 15 parts, chondroitin sulfate 12 parts.

Prepare the method for the capsule of this treatment gout, comprise the following steps:

A, by the purple Hylotelephium erythrostictum (Miq.) H.Ohba of described parts by weight, Radix campsis, Briar, Inonqqus obliquus, Li Jisheng, Bulbilus boussingaultiae pseudobaselloidis, CUIYUNCAO, Herba Lysimachiae pulverize after mixing, by solid-liquid ratio 1:8, add pure water, reflux, extract, 3 times, each 2 hours, merge backflow; Be condensed into the extractum that relative density is 1.20 ~ 1.35 (35 DEG C);

B, in the extractum in step a, add the chondroitin sulfate powder of described parts by weight, after mix homogeneously, dry, incapsulate.In incapsulating according to every 0.45 gram one, each serving with 2 ~ 4, every day 2 ~ 3 times.

The present invention treats in the capsule prescription of gout, purple Hylotelephium erythrostictum (Miq.) H.Ohba heat-clearing and toxic substances removing; Sore; To dispel the wind analgesia; Invigorating heart and kidney; Main pyogenic skin infection and carbuncle-abscess; Scrofula; Blood stasis; Headache due to common cold; Wind and cold arthralgia pain; Gout; Pneumonia; Pulmonary tuberculosis; Cardiopalmus; Asthenia.Radix campsis cooling blood, expelling wind; Promoting blood circulation to remove obstruction in the collateral; Main blood hot air wind producing; Itching over the body; Rubella; Waist foot is unsuccessful; Gout; Rheumatic arthralgia; Traumatic injury.Briar expelling wind and removing dampness; Promoting blood circulation and detoxication; Main air numbness; Severe and migratory arthralgia gout; Exogenous cough; Sore, carbuncle and painful swelling; Traumatic injury.Inonqqus obliquus is not only a kind of tonic, and is the cleaning agent of blood and the alleviant of pain; Improve and Polyglucan cortex; There is obvious therapeutical effect to hepatitis, gastritis, duodenal ulcer, nephritis, and have therapeutical effect to vomiting, diarrhoea, gastrointestinal dysfunction.Li Jisheng wind-damp dispelling; Invigorating the liver and kidney; Promoting flow of QI and blood; Pain relieving; Main air pain of dampness syndrome; Numb limbs and tense tendons; Soreness of waist and knee joint; Have a dizzy spell; Traumatic injury.Bulbilus boussingaultiae pseudobaselloidis liver and kidney tonifying, nourishing, strong waist knee joint, Sweeling-eliminating medicine powder expectorant; Cure mainly waist knee joint arthralgia pain, weak after being ill, traumatic injury, fracture.CUIYUNCAO clearing away heat-damp and promoting diuresis, hemostasis, cough-relieving; For acute icteric infectious hepatitis, cholecystitis, enteritis, dysentery, oedema due to nephritis, urinary system infection, rheumatic arthritis, hemoptysis of pulmonary tuberculosis; Furuncle and phyma is controlled in external, burn and scald, traumatic hemorrhage, traumatic injury.Herba Lysimachiae relieving stranguria by diuresis; Heat-clearing and toxic substances removing; Dissipating blood stasis for subsidence of swelling; Cure mainly liver and gall and urinary system calculus; Pyretic stranguria; Oedema due to nephritis; Jaundice due to damp-heat; Sore carbuncle; Venom; Traumatic injury.Chondroitin sulfate as health food or health care medicine prolonged application in diseases such as control coronary heart diseases and angina pectoris, myocardial infarction, coronary atherosclerosis, myocardial ischemia, without obvious toxic and side effects, be used for the treatment of neuralgia, nervous migraine, arthralgia, arthritis and omoplate arthralgia in addition, abdominal postoperative pain etc.

All medicine compatibilities, have promoting blood circulation to remove obstruction in the collateral, liver and kidney tonifying, analgesic effect of dispeling the wind; Each drug component synergism is given prominence to; And relative and Western medicine, little to Liver and kidney toxic and side effects; The curative effect being used for the treatment of gout is very remarkable.

Detailed description of the invention

The invention will be further described for embodiment plan given below; but can not be interpreted as it is limiting the scope of the invention; those skilled in the art to nonessential improvement and adjustment more of the present invention, still belong to protection scope of the present invention according to content of the present invention.

Embodiment 1, a, get purple Hylotelephium erythrostictum (Miq.) H.Ohba 24 grams, Radix campsis 19 grams, Briar 16 grams, Inonqqus obliquus 24 grams, Li Jisheng 19 grams, Bulbilus boussingaultiae pseudobaselloidis 16 grams, CUIYUNCAO 22 grams, Herba Lysimachiae 15 grams pulverize after mixing, by solid-liquid ratio 1:8, add pure water, reflux, extract, 3 times, each 2 hours, merges backflow; Be condensed into the extractum that relative density is 1.20 ~ 1.35 (35 DEG C); B, in the extractum in step a, add 12 grams, chondroitin sulfate powder, after mix homogeneously, dry, incapsulate.In incapsulating according to every 0.45 gram one, each serving with 2 ~ 4, every day 2 ~ 3 times.

Embodiment 2, a, get purple Hylotelephium erythrostictum (Miq.) H.Ohba 23 grams, Radix campsis 18 grams, Briar 15 grams, Inonqqus obliquus 23 grams, Li Jisheng 18 grams, Bulbilus boussingaultiae pseudobaselloidis 15 grams, CUIYUNCAO 20 grams, Herba Lysimachiae 13 grams pulverize after mixing, by solid-liquid ratio 1:8, add pure water, reflux, extract, 3 times, each 2 hours, merges backflow; Be condensed into the extractum that relative density is 1.20 ~ 1.35 (35 DEG C); B, in the extractum in step a, add 10 grams, chondroitin sulfate powder, after mix homogeneously, dry, incapsulate.In incapsulating according to every 0.45 gram one, each serving with 2 ~ 4, every day 2 ~ 3 times.

Embodiment 3, a, get purple Hylotelephium erythrostictum (Miq.) H.Ohba 25 grams, Radix campsis 20 grams, Briar 18 grams, Inonqqus obliquus 25 grams, Li Jisheng 20 grams, Bulbilus boussingaultiae pseudobaselloidis 17 grams, CUIYUNCAO 23 grams, Herba Lysimachiae 16 grams pulverize after mixing, by solid-liquid ratio 1:8, add pure water, reflux, extract, 3 times, each 2 hours, merges backflow; Be condensed into the extractum that relative density is 1.20 ~ 1.35 (35 DEG C); B, in the extractum in step a, add 13 grams, chondroitin sulfate powder, after mix homogeneously, dry, incapsulate.In incapsulating according to every 0.45 gram one, each serving with 2 ~ 4, every day 2 ~ 3 times.

Pertinent clinical data is as follows: physical data: in observed 524 routine patients, man 243 example, female 281 example; At minimum 19 years old of age, maximum 71 years old, wherein the most elder of the course of disease 9 years, the shortest 1 month, is divided into two groups at random, matched group 262 example, treatment group 262 example.

Diagnosis basis: often have heating, fear of cold, unable, headache, anorexia, arthralgia.Affected joints is common with thumb, l metatarsophalangeal joints, is secondly ankle, hands, wrist, knee joint, elbow, foot.Joint is red, swollen, hot, bitterly, limitation of activity.Local skin desquamation and pruritus, arthroedema, joint deformity.Effects of Colchicine In Treating has specially good effect.The visible affected joints of X-ray film, at the sclerotin of bone cartilage edge adjacent joints, has circular or the bright defect of irregular sample of giving a farfetched interpretation.Pyelography visible light-transmissive renal calculus shadow.The aciculiform urate crystal having two-fold optical phenomenon in leukocyte can be found in the synovial bursa liquid of joint.Male's blood uric acid >417 μm of ol/L (7.0mg/dl), women's blood uric acid >357 μm of ol/L (6.0mg/ml).

Therapeutic Method: treatment group, the present invention treats the capsule of gout, oral 3 at every turn, every day 3 times.。Matched group, patient gives allopurinol (specification 100mg, lot number H 11020716), 0.1 g/ time, 2 times/d.The course for the treatment of is 3 months.The all inactive other drug of treatments period, strict alleviating alcohol addiction, the food that the edible exogenous purine of restriction is higher, prevent the Study of Interference result, all give great quantity of water drinking to promote urate excretion simultaneously.

Efficacy evaluation: (1) cures: symptom all disappears, joint function recovery is normal, and uric acid is normal; (2) effective: symptomatology is eliminated or cardinal symptom is eliminated, and function of joint is recovered substantially, and can normally work and work, uric acid obviously reduces; (3) effective: cardinal symptom is eliminated to some extent, and function of joint makes moderate progress, life can take care of oneself but can not take part in the work, and uric acid decreases; (4) invalid: compared with before treatment, each index is all unchanged.Total effective rate=cure rate+obvious effective rate+effective percentage.After two groups of case treatments, efficacy result is in table 1:

Claims (3)

1. treat the capsule of gout for one kind; It is characterized in that being made up of the crude drug of following parts by weight: purple Hylotelephium erythrostictum (Miq.) H.Ohba 23 ~ 25 parts, Radix campsis 18 ~ 20 parts, Briar 15 ~ 18 parts, Inonqqus obliquus 23 ~ 25 parts, Li Jisheng 18 ~ 20 parts, Bulbilus boussingaultiae pseudobaselloidis 15 ~ 17 parts, CUIYUNCAO 20 ~ 23 parts, Herba Lysimachiae 13 ~ 16 parts, chondroitin sulfate 10 ~ 13 points.

2. the capsule for the treatment of gout according to claim 1; It is characterized in that by the crude drug system of following parts by weight: purple Hylotelephium erythrostictum (Miq.) H.Ohba 24, Radix campsis 19 parts, Briar 16 parts, Inonqqus obliquus 24 parts, Li Jisheng 19 parts, Bulbilus boussingaultiae pseudobaselloidis 16 parts, CUIYUNCAO 22 parts, Herba Lysimachiae 15 parts, chondroitin sulfate 12 parts.

3. prepare a method for the capsule for the treatment of gout described in claim 1, it is characterized in that comprising the following steps:

A, by the purple Hylotelephium erythrostictum (Miq.) H.Ohba of described parts by weight, Radix campsis, Briar, Inonqqus obliquus, Li Jisheng, Bulbilus boussingaultiae pseudobaselloidis, CUIYUNCAO, Herba Lysimachiae pulverize after mixing, by solid-liquid ratio 1:8, add pure water, reflux, extract, 3 times, each 2 hours, merge backflow; Be condensed into the extractum that relative density is 1.20 ~ 1.35 (35 DEG C);

B, in the extractum in step a, add the chondroitin sulfate powder of described parts by weight, after mix homogeneously, dry, incapsulate.