CN104800759A - Traditional Chinese medicine composition for treating rheumatic arthritis - Google Patents
Traditional Chinese medicine composition for treating rheumatic arthritis Download PDFInfo
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- CN104800759A CN104800759A CN201510216068.8A CN201510216068A CN104800759A CN 104800759 A CN104800759 A CN 104800759A CN 201510216068 A CN201510216068 A CN 201510216068A CN 104800759 A CN104800759 A CN 104800759A
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Abstract
The invention provides a traditional Chinese medicine composition for treating rheumatic arthritis. The traditional Chinese medicine composition is prepared from nicandra physalodes, zornia gibbosa, atractylodes macrocephala, mulberry twigs and the like, is prepared through water extract and alcohol precipitate and spray drying, and can be used for treating rheumatic arthritis.
Description
Technical field
The present invention relates to technical field of Chinese medicines, be specifically related to a kind of Chinese medicine composition being used for the treatment of rheumatic arthritis and its preparation method and application.
Background technology
Rheumatic arthritis is a kind of common acute or chronic ICT.Because the blood circulation of patient is obstructed, cause muscle or the nutrition required for tissue cannot be carried by blood circulation, cause that patient muscle lacks nutrition and accelerated ageing becomes stiff, serious meeting causes patient muscle and blood vessel die back, some patients and can occur disabling and viscera function exhaustion in joint.Be of no curative effect particularly preferred medicine at present.
Summary of the invention
Goal of the invention: in order to solve the problem, the object of the present invention is to provide a kind of Chinese medicine composition being used for the treatment of rheumatic arthritis and its preparation method and application.
Technical scheme: the object of the invention is by following scheme realize:
Be used for the treatment of a Chinese medicine composition for rheumatic arthritis, it is extracted by the crude drug of following parts by weight and prepares: large thousand lifes 12 parts, Herba Zornia Diphyllae 14 parts, the Rhizoma Atractylodis Macrocephalae 10 parts, Ramulus Mori 10 parts, Ramulus Cinnamomi 10 parts, Radix Curcumae 10 parts, Rhizoma Corydalis 10 parts, Fructus Toosendan 10 parts, Rhizoma Chuanxiong 10 parts, Caulis Lonicerae 15 parts, the Rhizoma Anemarrhenae 10 parts, Radix Paeoniae Rubra 10 parts, Radix Salviae Miltiorrhizae 10 parts, Cortex Moutan 10 parts, Rhizoma Et Radix Notopterygii 10 parts, Radix Angelicae Pubescentis 10 parts, Semen Coicis 30 parts, Cortex Phellodendri 10 parts, Herb Gynostemmae Pentaphylli 30 parts, Caulis Spatholobi 15 parts, 30 parts, the Radix Rehmanniae, Rhizoma Polygoni Cuspidati 10 parts, Rhizoma Alismatis 10 parts, Herba Lycopi 10 parts, 6 parts, Radix Glycyrrhizae.
The described Chinese medicine composition being used for the treatment of rheumatic arthritis, described crude drug adds adjuvant and makes tablet, capsule or granule after extracting.
The described Chinese medicine composition being used for the treatment of rheumatic arthritis, described adjuvant is one or more of dextrin, lactose, starch, sucrose, glucose, microcrystalline Cellulose, mannose, methylcellulose, hydroxypropyl cellulose, carboxymethyl cellulose and stevioside.
The described Chinese medicine composition being used for the treatment of rheumatic arthritis, preparation method comprises the steps: material merging of getting it filled, and decocts with water twice, collecting decoction, when being evaporated to 65 DEG C, relative density is the extractum of 1.15-1.20, adds ethanol and makes the percent by volume of alcohol content reach 75-85%, stir, leave standstill, filter, during filtrate reduced in volume to 65 DEG C, relative density is 1.25-1.30, and reclaim ethanol, obtain concentrated solution, by concentrated solution spraying dry, add adjuvant and make capsule, tablet, granule.
The described Chinese medicine composition being used for the treatment of rheumatic arthritis, in preparation method, decocting condition is: first time adds water as the 8-12 times amount of medical material weight, decocts 1-2h, and second time adds water as the 6-10 times amount of medical material weight, decocts 1-2h.
The described Chinese medicine composition being used for the treatment of rheumatic arthritis, in preparation method step, spray drying condition is: inlet temperature is 100-120 DEG C, and leaving air temp is 80-90 DEG C, and temperature of charge is 70-90 DEG C, atomizing pressure is 0.2-0.4 MPa, and spray velocity is 5-10ml/s.
The described application of Chinese medicine composition in the medicine of preparation treatment rheumatic arthritis being used for the treatment of rheumatic arthritis.
Above-mentioned large thousand raw Classification system Nicandra physaloides, calm, eliminate the phlegm, heat-clearing and toxic substances removing.For rabies, psychosis, epilepsy, rheumatic arthritis, nasal sinusitis, flu, urinary tract infection, furuncle.The present invention is used as medicine with root.
Herba Zornia Diphyllae, Classification system Zornia gibbosa Spanog.: heat-clearing and toxic substances removing, removing pathogenic heat from blood and toxic substance from the body.For flu, pharyngolaryngitis, acute icterohepatitis, acute gastroenteritis, acute appendicitis, infantile malnutrition, acute mastitis, eye keratitis; Traumatic injury is controlled in external, carbuncle furuncle and phyma poison, venom.The present invention is with all herbal medicine.All the other Chinese medicines are pharmacopeia kind.
Beneficial effect: the present invention large thousand is raw calm, eliminate the phlegm, heat-clearing and toxic substances removing, Herba Zornia Diphyllae heat-clearing and toxic substances removing, removing pathogenic heat from blood and toxic substance from the body is monarch drug altogether, the Rhizoma Atractylodis Macrocephalae, Ramulus Mori, Ramulus Cinnamomi, Radix Curcumae, Rhizoma Corydalis, Fructus Toosendan, Rhizoma Chuanxiong, Caulis Lonicerae, the Rhizoma Anemarrhenae, Radix Paeoniae Rubra, Radix Salviae Miltiorrhizae, Cortex Moutan, Rhizoma Et Radix Notopterygii, Radix Angelicae Pubescentis, Semen Coicis, Cortex Phellodendri, Herb Gynostemmae Pentaphylli, Caulis Spatholobi, the Radix Rehmanniae, Rhizoma Polygoni Cuspidati, Rhizoma Alismatis, Herba Lycopi's blood circulation promoting and blood stasis dispelling, channels sootheing and network vessel quickening, strengthening the tendons and bones, pathogenic fire purging dampness are ministerial drug, Radix Glycyrrhizae coordinating the actions of various ingredients in a prescription, is used for the treatment of rheumatic arthritis respond well.
Detailed description of the invention
Form by the following examples, foregoing of the present invention is described in further detail again, but this should be interpreted as that the scope of the above-mentioned theme of the present invention is only limitted to following example, all technology realized based on foregoing of the present invention all belong to scope of the present invention.
1, embodiment is prepared
Embodiment 1: get large thousand raw 12g, Herba Zornia Diphyllae 14g, Rhizoma Atractylodis Macrocephalae 10g, Ramulus Mori 10g, Ramulus Cinnamomi 10g, Radix Curcumae 10g, Rhizoma Corydalis 10g, Fructus Toosendan 10g, Rhizoma Chuanxiong 10g, Caulis Lonicerae 15g, Rhizoma Anemarrhenae 10g, Radix Paeoniae Rubra 10g, Radix Salviae Miltiorrhizae 10g, Cortex Moutan 10g, Rhizoma Et Radix Notopterygii 10g, Radix Angelicae Pubescentis 10g, Semen Coicis 30g, Cortex Phellodendri 10g, Herb Gynostemmae Pentaphylli 30g, Caulis Spatholobi 15g, Radix Rehmanniae 30g, Rhizoma Polygoni Cuspidati 10g, Rhizoma Alismatis 10g, Herba Lycopi 10g, Radix Glycyrrhizae 6g medical material merges, and decocts with water twice, and first time adds water as 8 times amount of medical material weight, decocts 1h, and second time adds water as 6 times amount of medical material weight, decocts 1h, collecting decoction, 0.07MPa, when being evaporated to 65 DEG C at 60-70 DEG C, relative density is 1.10, adds 95% (v/v) ethanol and makes alcohol content reach 85% (v/v), stirs, and leaves standstill 24 hours, and decompression filtrate recycling ethanol is also concentrated, and filtrate is at 0.07MPa, under 65 DEG C of conditions, concentrating under reduced pressure becomes to relative density when 65 DEG C is 1.30, and (condition is inlet temperature is 120 DEG C to spraying dry, and leaving air temp is 100 DEG C, and temperature of charge is 90 DEG C, and atomizing pressure is 0.4 MPa, and spray velocity is 10ml/s.), add starch 50g, mix homogeneously, with appropriate 80% (v/v) ethanol wet, soft material processed, cross 30 mesh sieves and granulate, in 70 ~ 80 DEG C of dryings, with 60 mesh sieve granulate, tabletting, sugar coating, subpackage, outer package, censorship is qualified, obtains tablet.
Embodiment 2: get large thousand raw 12g, Herba Zornia Diphyllae 14g, Rhizoma Atractylodis Macrocephalae 10g, Ramulus Mori 10g, Ramulus Cinnamomi 10g, Radix Curcumae 10g, Rhizoma Corydalis 10g, Fructus Toosendan 10g, Rhizoma Chuanxiong 10g, Caulis Lonicerae 15g, Rhizoma Anemarrhenae 10g, Radix Paeoniae Rubra 10g, Radix Salviae Miltiorrhizae 10g, Cortex Moutan 10g, Rhizoma Et Radix Notopterygii 10g, Radix Angelicae Pubescentis 10g, Semen Coicis 30g, Cortex Phellodendri 10g, Herb Gynostemmae Pentaphylli 30g, Caulis Spatholobi 15g, Radix Rehmanniae 30g, Rhizoma Polygoni Cuspidati 10g, Rhizoma Alismatis 10g, Herba Lycopi 10g, Radix Glycyrrhizae 6g medical material merges, and decocts with water twice, and first time adds water as 10 times amount of medical material weight, decocts 1.5h, and second time adds water as 8 times amount of medical material weight, decocts 1.5h, collecting decoction, 0.07MPa, when being evaporated to 65 DEG C at 60-70 DEG C, relative density is 1.15, adds 95% (v/v) ethanol and makes alcohol content reach 75% (v/v), stirs, and leaves standstill 24 hours, and decompression filtrate recycling ethanol is also concentrated, and filtrate is at 0.07MPa, under 65 DEG C of conditions, concentrating under reduced pressure becomes to relative density when 65 DEG C is 1.25, and (condition is inlet temperature is 100 DEG C to spraying dry, and leaving air temp is 80 DEG C, and temperature of charge is 80 DEG C, and atomizing pressure is 0.2 MPa, and spray velocity is 5ml/s.), add dextrin 50g etc., dry granulation, cross 60 mesh sieves, load No. 1 capsule capsule.
Embodiment 3: get large thousand raw 12g, Herba Zornia Diphyllae 14g, Rhizoma Atractylodis Macrocephalae 10g, Ramulus Mori 10g, Ramulus Cinnamomi 10g, Radix Curcumae 10g, Rhizoma Corydalis 10g, Fructus Toosendan 10g, Rhizoma Chuanxiong 10g, Caulis Lonicerae 15g, Rhizoma Anemarrhenae 10g, Radix Paeoniae Rubra 10g, Radix Salviae Miltiorrhizae 10g, Cortex Moutan 10g, Rhizoma Et Radix Notopterygii 10g, Radix Angelicae Pubescentis 10g, Semen Coicis 30g, Cortex Phellodendri 10g, Herb Gynostemmae Pentaphylli 30g, Caulis Spatholobi 15g, Radix Rehmanniae 30g, Rhizoma Polygoni Cuspidati 10g, Rhizoma Alismatis 10g, Herba Lycopi 10g, Radix Glycyrrhizae 6g medical material merges, and decocts with water twice, and first time adds water as 12 times amount of medical material weight, decocts 2h, and second time adds water as 10 times amount of medical material weight, decocts 2h, collecting decoction, 0.07MPa, when being evaporated to 65 DEG C at 60-70 DEG C, relative density is 1.15, adds 95% (v/v) ethanol and makes alcohol content reach 75% (v/v), stirs, and leaves standstill 24 hours, and decompression filtrate recycling ethanol is also concentrated, and filtrate is at 0.07MPa, under 65 DEG C of conditions, concentrating under reduced pressure becomes to relative density when 65 DEG C is 1.25, and (condition is inlet temperature is 110 DEG C to spraying dry, and leaving air temp is 85 DEG C, and temperature of charge is 85 DEG C, and atomizing pressure is 0.3 MPa, and spray velocity is 7.5ml/s.), add above-mentioned Benexate Hydrochloride, pulverize, then add lactose 50g, with appropriate 80% (v/v) ethanol wet, soft material processed, cross 14 mesh sieves and granulate, 50-80 DEG C of drying, 60 order granulate, obtain granule.
2. the present invention treats the experimentation of rheumatic arthritis
The preparation of 2.1 samples: by the preparation of granule embodiment method, every bag containing crude drug amount 30g.
2.2 dosages: by Mice Body restatement, gavage low dosage, middle dosage and high dose are respectively 10g crude drug amount/kg, 20g crude drug amount/kg and 40g crude drug amount/kg.
2.3 instrument and reagent
DKZ-2 type electric heating constant-temperature water-bath tank (the upper grand experimental facilities company limited of Nereid), 8452A type ultraviolet spectrophotometer (hewlette-packard); TG328A type photoelectric analytical balance (Shanghai balance equipment factory).Glacial acetic acid (Shanghai reagent four factory, lot number: 120402) aspirin tablet, Nanjing Pharmaceutical Plant, lot number 20130216
2.3 animal Kunming mouses 210, female, body weight (20.1 ± 2.4) g, is provided (SYXK (Soviet Union) 2000-0053) by Nanjing Medical University's Experimental Animal Center.
2.4 analgesic activities (hot plate method) are tested
2.4.1 50 mices are divided 5 groups, i.e. negative control group, positive controls, the large, medium and small dosage group of the present invention by grouping and administration at random, and often group is 10; Next day gastric infusion, continuous 7d, the large, medium and small dosage of the present invention; Positive controls is to aspirin tablet, and dosage is 20gkg-1d-1; Negative control group gavage 0.9% sodium chloride solution, volume is every 2ml, carries out analgesic activity (hot plate method) experiment after drug withdrawal 24h.
2.4.2 by water bath topped up with water, the water surface is made to contact hot plate, regulating thermostatic device makes water temperature control at 55 ± 0.5 DEG C, as thermostimulation after heating, with stopwatch record mice from dropping into hot plate to occurring that licking the sufficient time (s) (surveys 2 times as the pain threshold of this Mus, 60 seconds persons are no more than for qualified with meansigma methods), in administration 1h after the 3rd day, then survey every pain threshold.
2.5 analgesic activities (writhing method) are tested
2.5.1 50 mices are divided 5 groups, i.e. negative control group, positive controls, the large, medium and small dosage group of the present invention by grouping and administration at random, and often group is 10; Next day gastric infusion, continuous 7d, the large, medium and small dosage of the present invention is respectively 40,20,10gkg-1d-1 (suitable crude drug); Positive controls is to aspirin tablet, and dosage is 20gkg-1d-1; Negative control group gavage 0.9% sodium chloride solution, volume is every 2ml, carries out analgesic activity (writhing method) experiment after drug withdrawal 24h.
2.5.2 after administration in the 3rd day 1 hour, every Mus lumbar injection 0.6% glacial acetic acid 0.1ml/10g, after record injection algogen, each Mus writhing number of times in 10min, compared group difference.
Table 1 the present invention is on the impact (x ± s) of mice analgesic activity
Compare with negative control group, * 1P<0.01, * 2P<0.05
2.6 granulation tissue hyperplasia tests
2.6.1 divide into groups and test to divide 5 groups at random by 50 mices, i.e. model group, positive controls, the large, medium and small dosage group of the present invention, often group is 10, adopts the burying storage modeling of cotton balls oxter.
2.6.2 administration gastric infusion next day, continuous 7d, the large, medium and small dosage of the present invention; Positive controls is the same; Model group gavage 0.9% sodium chloride solution, volume is every 2ml, 30min after last administration, by sacrifice of animal, cotton balls granulation tissue is taken out, dries and weigh in 60 DEG C of baking boxs.Deduct cotton balls quality with cotton balls granulation tissue dry weight, be granulation tissue net weight.
Table 2 the present invention buries the impact (x ± s) bringing out granulation tissue hyperplasia on mice oxter cotton balls
Compare with negative control group, * 1P<0.01, * 2P<0.05
2.7 experiment conclusion
2.7.1 the big-and-middle dosed administration group of the present invention can improve mice pain threshold and reduce acetic acid induced mice writhing number of times, compare with negative control group, there is significant difference (P<0.05 or P<0.01), show that the present invention has obvious analgesic activity.Size dosed administration group can alleviate granulation tissue weight, cotton balls oxter is buried and brings out granulation tissue hyperplasia and have obvious inhibitory action, compare with negative control group and have significant difference (P<0.01, P<0.05), show that the present invention has obvious antiinflammatory action.To sum up, the present invention has certain therapeutical effect to rheumatic arthritis.
Claims (7)
1. one kind is used for the treatment of the Chinese medicine composition of rheumatic arthritis, it is characterized in that, it is extracted by the crude drug of following parts by weight and prepares: large thousand life 12 parts, Herba Zornia Diphyllae 14 parts, the Rhizoma Atractylodis Macrocephalae 10 parts, Ramulus Mori 10 parts, Ramulus Cinnamomi 10 parts, Radix Curcumae 10 parts, Rhizoma Corydalis 10 parts, Fructus Toosendan 10 parts, Rhizoma Chuanxiong 10 parts, Caulis Lonicerae 15 parts, the Rhizoma Anemarrhenae 10 parts, Radix Paeoniae Rubra 10 parts, Radix Salviae Miltiorrhizae 10 parts, Cortex Moutan 10 parts, Rhizoma Et Radix Notopterygii 10 parts, Radix Angelicae Pubescentis 10 parts, Semen Coicis 30 parts, Cortex Phellodendri 10 parts, Herb Gynostemmae Pentaphylli 30 parts, Caulis Spatholobi 15 parts, 30 parts, the Radix Rehmanniae, Rhizoma Polygoni Cuspidati 10 parts, Rhizoma Alismatis 10 parts, Herba Lycopi 10 parts, 6 parts, Radix Glycyrrhizae.
2. the Chinese medicine composition being used for the treatment of rheumatic arthritis according to claim 1, is characterized in that, described crude drug adds adjuvant and makes tablet, capsule or granule after extracting.
3. the Chinese medicine composition being used for the treatment of rheumatic arthritis according to claim 2, it is characterized in that, described adjuvant is one or more of dextrin, lactose, starch, sucrose, glucose, microcrystalline Cellulose, mannose, methylcellulose, hydroxypropyl cellulose, carboxymethyl cellulose and stevioside.
4. the Chinese medicine composition being used for the treatment of rheumatic arthritis according to claim 1, it is characterized in that, preparation method comprises the steps: material merging of getting it filled, decoct with water twice, collecting decoction, when being evaporated to 65 DEG C, relative density is the extractum of 1.15-1.20, adding ethanol makes the percent by volume of alcohol content reach 75-85%, stirs, and leaves standstill, filter, during filtrate reduced in volume to 65 DEG C, relative density is 1.25-1.30, and reclaims ethanol, obtains concentrated solution, by concentrated solution spraying dry, add adjuvant and make capsule, tablet, granule.
5. the Chinese medicine composition being used for the treatment of rheumatic arthritis according to claim 4, it is characterized in that, in preparation method, decocting condition is: first time adds water as the 8-12 times amount of medical material weight, decocts 1-2h, second time adds water as the 6-10 times amount of medical material weight, decocts 1-2h.
6. the Chinese medicine composition being used for the treatment of rheumatic arthritis according to claim 4, it is characterized in that, in preparation method step, spray drying condition is: inlet temperature is 100-120 DEG C, leaving air temp is 80-90 DEG C, temperature of charge is 70-90 DEG C, atomizing pressure is 0.2-0.4 MPa, and spray velocity is 5-10ml/s.
7. described in claim 1, be used for the treatment of the application of Chinese medicine composition in the medicine for the treatment of rheumatic arthritis of rheumatic arthritis.
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105296156A (en) * | 2015-11-13 | 2016-02-03 | 李洋 | Extraction method and applications of camphor wood oil essence |
| CN105582096A (en) * | 2016-02-26 | 2016-05-18 | 南京正亮医药科技有限公司 | Preparation method and application of Feng Tong Ning tablet |
| CN105663789A (en) * | 2016-03-03 | 2016-06-15 | 冯字 | Traditional Chinese medicine composition for treating rheumatic arthritis as well as preparation method and application thereof |
| CN107582730A (en) * | 2017-11-03 | 2018-01-16 | 黑龙江中医药大学 | A kind of Chinese medical extract for treating rheumatoid arthritis and preparation method thereof |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102935133A (en) * | 2012-12-08 | 2013-02-20 | 南京正宽医药科技有限公司 | Traditional Chinese medicine composition for treating rheumatic arthritis as well as preparation method and application thereof |
| CN104306784A (en) * | 2014-11-08 | 2015-01-28 | 陈爱华 | Traditional Chinese medicine composition for treating rheumatoid arthritis as well as preparation method and application thereof |
-
2015
- 2015-04-30 CN CN201510216068.8A patent/CN104800759A/en not_active Withdrawn
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102935133A (en) * | 2012-12-08 | 2013-02-20 | 南京正宽医药科技有限公司 | Traditional Chinese medicine composition for treating rheumatic arthritis as well as preparation method and application thereof |
| CN104306784A (en) * | 2014-11-08 | 2015-01-28 | 陈爱华 | Traditional Chinese medicine composition for treating rheumatoid arthritis as well as preparation method and application thereof |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105296156A (en) * | 2015-11-13 | 2016-02-03 | 李洋 | Extraction method and applications of camphor wood oil essence |
| CN105582096A (en) * | 2016-02-26 | 2016-05-18 | 南京正亮医药科技有限公司 | Preparation method and application of Feng Tong Ning tablet |
| CN105663789A (en) * | 2016-03-03 | 2016-06-15 | 冯字 | Traditional Chinese medicine composition for treating rheumatic arthritis as well as preparation method and application thereof |
| CN107582730A (en) * | 2017-11-03 | 2018-01-16 | 黑龙江中医药大学 | A kind of Chinese medical extract for treating rheumatoid arthritis and preparation method thereof |
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Application publication date: 20150729 |