CN104800755A - Medicament for treating gallstones and preparation method - Google Patents
Medicament for treating gallstones and preparation method Download PDFInfo
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- CN104800755A CN104800755A CN201510192924.0A CN201510192924A CN104800755A CN 104800755 A CN104800755 A CN 104800755A CN 201510192924 A CN201510192924 A CN 201510192924A CN 104800755 A CN104800755 A CN 104800755A
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Abstract
The invention discloses a medicament for treating gallstones. The medicament is prepared from the following main raw materials in parts by mass: 10-17 parts of poria cocos, 12-16 parts of dianthus superbus, 11-15 parts of common achyranthes herb, 7-13 parts of polygonum cuspidatum, 10-13 parts of clerodendranthus spicatus, 13-18 parts of curcuma aromatica, 10-13 parts of ranunculus ternatus thumb, 8-12 parts of szechwan Chinaberry fruit, 11-14 parts of centipeda minima, 9-12 parts of chrysosplenium pilosum, 8-13 parts of scandent hop and 13-16 parts of cape jasmine. The medicament has the efficacy of discharging liver and regulating qi, relieving depression and interior syndromes, clearing heat and promoting dieresis and removing blood stasis and removing stasis, can be quickly absorbed, is good in curative effect, comprehensively kill germs to control gallbladder infection, and effectively prevents the gallstones from regrowth. Meanwhile, gallstones can be dissolved quickly, and are broken finally to be discharged out of the body of a patient, choleresis and diuresis are realized and the gallstones can be cured thoroughly.
Description
Technical field
The present invention relates to traditional Chinese medicine field, particularly a kind of medicament and method for making for the treatment of cholelithiasis.
Background technology
Cholelithiasis refers to the disease caused by calculus occurred in gallbladder, is a kind of commonly encountered diseases.Can cause the disease of the symptoms such as violent stomachache, jaundice, fever, being also called cholelithiasis, is modal biliary tract.Be mainly seen in adult, women is more than male, and within 40 years old, sequela rate increases with the age and increases.Calculus is cholesterol calculus or the mixed calculus based on cholesterol and black bile pigment calculus.Along with growth in the living standard, the change of dietary habit, the improvement of sanitary condition, the cholelithiasis of China changes into based on gallbladder cholesterol calculus for main gradually by with the bile pigment calculus of bile duct.
The origin cause of formation of cholelithiasis is very complicated, and some is not modifiable factor, such as: the age increased gradually, women, race, gene and family history; Some is acquired disposition, and part can reverse, such as: gestation, obesity, low fiber, high calorie dietary structure, for a long time fasting, some drugs as ceftriaxone, lipid lowerers, oral contraceptive, metabolism syndrome, special disease etc.Cholelithiasis can be divided into cholesterol calculus, bile pigment calculus and combination calculus three class according to the chemical composition of calculus.Most of Patients with Cholelithiasis is all the mixed type calculus based on cholesterol calculus.And the concrete Crack cause of cholelithiasis is not yet completely clear so far, considers at present with lipid metabolism, cholesterol supersaturation, nucleation process is abnormal, gallbladder function is abnormal, the many factors such as antibacterial and genetic fragment is closely related.
Chinese medicine thinks that the formation of cholelithiasis is relevant to gallbladder liver, and gallbladder depends on liver, and the operation of gallbladder and irritability and taste assimilate food elite, has excretion absurd creature function.Due to eating and drinking without temperance, or eating and drinking too much at one meal, impairing the spleen and stomach, dysfunction of the spleen in transportation, water-damp not being transformed, amass and wet into expectorant, raw in expectorant is mixed, hinder mechanism of qi, the catharsis of depression and stagnation of QI bile is not normal, strongly fragrant heat-transformation fire-transformation of a specified duration, phlegm-damp heat-dissipating, damp and hotly ties mutually with expectorant, and combination of phlegm and heat damp-heat accumulation stone becomes cholelithiasis for a long time.In addition, surfeit delicious food savoury, or insobriety at ordinary times, or surfeit is pungent, make in damp-heat in middle-JIAO raw, soil is counter insults wood, and damp and hot fumigation is in liver and gall, and liver and gall are lost in catharsis, and cholestasis is accumulate steaming also can form cholelithiasis by damp and hot.
At present, the medicine for the treatment of cholelithiasis is a lot, publication number CN 104225493 A(application number 201410515573.8) patent document discloses a kind of Chinese medicine for the treatment of cholelithiasis, be made up of the raw material of following weight, Radix Bupleuri 10-20 gram, Pericarpium Citri Reticulatae Viride 10-20 gram, Pericarpium Citri Reticulatae 10-20 gram, Radix Curcumae 10-20 gram, Rhizoma Corydalis 10-20 gram, Endothelium Corneum Gigeriae Galli 10-20 gram, Radix Et Rhizoma Rhei 10-20 gram, Fructus Aurantii Immaturus 10-20 gram, Rhizoma Corydalis 10-20 gram, Radix Scutellariae 10-20 gram, Semen Plantaginis 10-20 gram, Fructus Aurantii 10-20 gram, Radix Aucklandiae 10-20 gram, Cortex Magnoliae Officinalis 10-20 gram, Fructus Toosendan 10-20 gram, Rhizoma Polygoni Cuspidati 10-20 gram, Herba Taraxaci 10-20 gram, Herba Artemisiae Scopariae 10-20 gram, Poria 10-20 gram, Radix Pseudostellariae 10-20 gram, Radix Paeoniae Alba 10-20 gram, Flos Lonicerae 25 grams, Herba Lysimachiae 25 grams, Oletum Trogopterori 6 grams, 3 grams, Radix Glycyrrhizae.Publication number CN 104367934 A(application number 201310353020.2) patent document discloses a kind of combination of Chinese medicine for the treatment of cholelithiasis, composition percentage by weight is: Herba Lysimachiae 10%, Spora Lygodii 10%, Endothelium Corneum Gigeriae Galli 10%, Radix Curcumae 10%, Rhizoma Cyperi 10%, Radix Aucklandiae (Radix Vladimiriae) 10%, Rhizoma Corydalis 10%, Radix Et Rhizoma Rhei 10%, Artemisia anethoicles Mattf 5%, Radix Scutellariae 5%, Fructus Aurantii 5%, Radix Bupleuri 5%.Publication number CN 103585591 A(application number 201310624777.0) patent document discloses a kind of Chinese medicine for the treatment of cholelithiasis, be made up of the raw material of following weight proportioning: Radix Bupleuri 10-25, Fructus Aurantii Immaturus 10-20, Pericarpium Citri Reticulatae 15-30, Herba Centipedae 8-15, Radix Et Rhizoma Rhei 12-25, Herba Lysimachiae 30-50, Herba Artemisiae Scopariae 30-50, Radix Curcumae 12-20, Fructus Toosendan 12-25, Rhizoma Corydalis 5-10.
Current gallstone treatment method has a lot: operative treatment, extracorporeal shock-wave lithotomy etc.Although operation instant effect, risk is high, and expense is large, and relapse rate is high, and may leave sequela; External knock wave shock wave lithotripsy method can not be applicable to everyone, should not be suitable for, and shock wave has certain injury to human organ to the patient of some functional defecies and biliary tract stenosis or blocking; And for the medicine of calculus lithodialysis on market today, unsatisfactory curative effect, side effect is large, dangerous.
Summary of the invention
For the deficiencies in the prior art, an object of the present invention is to provide the medicament for the treatment of cholelithiasis, has depressed liver-energy dispersing and QI regulating, resolving depression Tongli, clearing away heat-damp and promoting diuresis, effect of blood stasis-eliminating and stagnation-dissipating, has obvious curative effect to cholelithiasis.Another object of the present invention is just to provide the preparation method of the medicament of above-mentioned treatment cholelithiasis.
Above-mentioned purpose of the present invention is achieved through the following technical solutions:
The medicament for the treatment of cholelithiasis, takes off the primary raw material stating weight proportion and is prepared from: Poria 10-17 part; Herba Dianthi 12-16 part; Radix achyranthis asperae (Herba Achyranthis Asperae) 11-15 part; Rhizoma Polygoni Cuspidati 7-13 part; Herba clerodendranthi spicati 10-13 part; Radix Curcumae 13-18 part; Radix Ranunculi Ternati 10-13 part; Fructus Toosendan 8-12 part; Herba Centipedae 11-14 part; Golden saxifrage 9-12 part; Herba humuli scandentis 8-13 part; Fructus Gardeniae 13-16 part.
The medicament for the treatment of cholelithiasis, preferred scheme is, takes off the primary raw material stating weight proportion and is prepared from: Poria 12-15 part; Herba Dianthi 13-15 part; Radix achyranthis asperae (Herba Achyranthis Asperae) 12-14 part; Rhizoma Polygoni Cuspidati 9-11 part; Herba clerodendranthi spicati 11-12 part; Radix Curcumae 15-17 part; Radix Ranunculi Ternati 11-12 part; Fructus Toosendan 9-11 part; Herba Centipedae 12-13 part; Golden saxifrage 10-11 part; Herba humuli scandentis 9-12 part; Fructus Gardeniae 14-15 part.
The medicament for the treatment of cholelithiasis, the scheme be more preferably is, takes off the primary raw material stating weight proportion and is prepared from
:13 parts, Poria; Herba Dianthi 14 parts; Radix achyranthis asperae (Herba Achyranthis Asperae) 13 parts; Rhizoma Polygoni Cuspidati 10 parts; Herba clerodendranthi spicati 11.5 parts; Radix Curcumae 16 parts; Radix Ranunculi Ternati 11.5 parts; Fructus Toosendan 10 parts; Herba Centipedae 12.5 parts; Golden saxifrage 10.5 parts; Herba humuli scandentis 11 parts; Fructus Gardeniae 14.5 parts.
Present invention also offers the preparation method medicament of above-mentioned treatment cholelithiasis being made pharmaceutically acceptable powder, decoction, pill, tablet and granule.
The preparation method of the medicament powder of described treatment cholelithiasis, step is as follows:
(1) be placed in glass container by Rhizoma Polygoni Cuspidati, add yellow wine, mix thoroughly, moistening is sucked to wine, loading steams in container, airtight, and water proof heating 6-10 hour, takes out, dry, pulverize, excessively 100-140 mesh sieve (preferred 110-130 mesh sieve excessively, was more preferably 120 mesh sieves);
(2) pot is burnt heat, add Testa Tritici, continue to fry to when smoldering, add Poria, Fructus Toosendan and Fructus Gardeniae, constantly stir, moderate heat fries 30-40 minute, takes out, and sieve removes Testa Tritici, dry in the air cool, pulverize, excessively 100-140 mesh sieve (preferred 110-130 mesh sieve excessively, was more preferably 120 mesh sieves);
(3) Herba Dianthi, Radix achyranthis asperae (Herba Achyranthis Asperae), Herba clerodendranthi spicati, Radix Curcumae, Radix Ranunculi Ternati, Herba Centipedae, golden saxifrage and Herba humuli scandentis are placed in pot, moderate heat fried dry, pulverize, excessively 120-160 mesh sieve (preferred 130-150 mesh sieve excessively, was more preferably 140 mesh sieves);
(4) by step (1)-(3) gained fine powder mix homogeneously, sterile packaged is carried out by pharmaceutically accepted specification.
The preparation method of the medicament powder of above-mentioned treatment cholelithiasis, the consumption of the preferred yellow wine of step (1) is the 20%-40% of Rhizoma Polygoni Cuspidati quality, and the consumption being more preferably yellow wine is 30% of Rhizoma Polygoni Cuspidati quality.
Instructions of taking: at every turn get 8-10g, is placed in tea bag, soaks, every day 2-3 time, 2 days courses for the treatment of by the warm waters of about 50 DEG C.
The preparation method of the medicament decoction of described treatment cholelithiasis, step is as follows:
(1) be placed in glass container by Rhizoma Polygoni Cuspidati, add yellow wine, mix thoroughly, moistening is sucked to wine, loads and steams in container, airtight, and water proof heating 6-10 hour, takes out, dry;
(2) pot is burnt heat, add Testa Tritici, continue to fry to when smoldering, add Poria, Fructus Toosendan and Fructus Gardeniae, constantly stir, moderate heat fries 30-40 minute, takes out, and sieve removes Testa Tritici, dries in the air cool;
(3) cleaned by Radix Curcumae, section, is placed in glass container, adds Chinese liquor (consumption of preferred Chinese liquor is the 10%-15% of Radix Curcumae quality, and the consumption being more preferably Chinese liquor is 13% of Radix Curcumae quality), moistening, fried dry;
(4) by Herba Dianthi, Radix achyranthis asperae (Herba Achyranthis Asperae), Herba clerodendranthi spicati, Radix Ranunculi Ternati, Herba Centipedae, golden saxifrage and Herba humuli scandentis mixing, be placed in container, soak 40-60 minute, be placed in marmite, add step (1)-(3) gains, decoct twice, each 30-40 minute, filters, merging filtrate, be concentrated into 1/2 of original volume, obtain decoction.
Instructions of taking: each 60-90ml, with the warm water delivery service of about 35 DEG C, every day 2-3 time, 2 days courses for the treatment of.
The preparation method of the medicament pill of described treatment cholelithiasis, step is as follows:
(1) be placed in glass container by Rhizoma Polygoni Cuspidati, add yellow wine, mix thoroughly, moistening is sucked to wine, loads and steams in container, airtight, and water proof heating 6-10 hour, takes out, dry;
(2) pot is burnt heat, add Testa Tritici, continue to fry to when smoldering, add Poria, Fructus Toosendan and Fructus Gardeniae, constantly stir, moderate heat fries 30-40 minute, takes out, and sieve removes Testa Tritici, dries in the air cool;
(3) cleaned by Radix Curcumae, section, is placed in glass container, adds Chinese liquor (consumption of preferred Chinese liquor is the 10%-15% of Radix Curcumae quality, and the consumption being more preferably Chinese liquor is 13% of Radix Curcumae quality), moistening, fried dry;
(4) by Herba Dianthi, Radix achyranthis asperae (Herba Achyranthis Asperae), Herba clerodendranthi spicati, Radix Ranunculi Ternati, Herba Centipedae, golden saxifrage and Herba humuli scandentis mixing, be placed in container, soak 40-60 minute, be placed in marmite, add step (1)-(3) gains, decoct twice, each 30-40 minute, filter, merging filtrate, being concentrated into relative density is 1.10-1.20(25 DEG C) thick paste, make pill (preferably make the pill that diameter is 3mm-5mm, be more preferably and make the pill that diameter is 4mm).
Instructions of taking: each 10-15 ball, every day 3 times, 2 days courses for the treatment of.
The preparation method of the medicament tablet of described treatment cholelithiasis, step is as follows:
(1) be placed in glass container by Rhizoma Polygoni Cuspidati, add yellow wine, mix thoroughly, moistening is sucked to wine, loads and steams in container, airtight, and water proof heating 6-10 hour, takes out, dry;
(2) pot is burnt heat, add Testa Tritici, continue to fry to when smoldering, add Poria, Fructus Toosendan and Fructus Gardeniae, constantly stir, moderate heat fries 30-40 minute, takes out, and sieve removes Testa Tritici, dries in the air cool;
(3) cleaned by Radix Curcumae, section, is placed in glass container, adds Chinese liquor (consumption of preferred Chinese liquor is the 10%-15% of Radix Curcumae quality, and the consumption being more preferably Chinese liquor is 13% of Radix Curcumae quality), moistening, fried dry;
(4) by Herba Dianthi, Radix achyranthis asperae (Herba Achyranthis Asperae), Herba clerodendranthi spicati, Radix Ranunculi Ternati, Herba Centipedae, golden saxifrage and Herba humuli scandentis mixing, be placed in container, soak 40-60 minute, be placed in marmite, add step (1)-(3) gains, decoct twice, each 30-40 minute, filters, merging filtrate, being concentrated into relative density is 1.10-1.20(25 DEG C) thick paste, make tablet.
Instructions of taking: each 2-3 sheet, every day 3 times, 2 days courses for the treatment of.
The preparation method of the pharmacy particle agent of described treatment cholelithiasis, step is as follows:
(1) be placed in glass container by Rhizoma Polygoni Cuspidati, add yellow wine, mix thoroughly, moistening is sucked to wine, loads and steams in container, airtight, and water proof heating 6-10 hour, takes out, dry;
(2) pot is burnt heat, add Testa Tritici, continue to fry to when smoldering, add Poria, Fructus Toosendan and Fructus Gardeniae, constantly stir, moderate heat fries 30-40 minute, takes out, and sieve removes Testa Tritici, dries in the air cool;
(3) cleaned by Radix Curcumae, section, is placed in glass container, adds Chinese liquor (consumption of preferred Chinese liquor is the 10%-15% of Radix Curcumae quality, and the consumption being more preferably Chinese liquor is 13% of Radix Curcumae quality), moistening, fried dry;
(4) by Herba Dianthi, Radix achyranthis asperae (Herba Achyranthis Asperae), Herba clerodendranthi spicati, Radix Ranunculi Ternati, Herba Centipedae, golden saxifrage and Herba humuli scandentis mixing, be placed in container, soak 40-60 minute, be placed in marmite, add step (1)-(3) gains, decoct twice, each 30-40 minute, filters, merging filtrate, being concentrated into relative density is 1.10-1.20(25 DEG C) thick paste, add simple syrup, mixing, makes uniform granule, be aided with pharmaceutically acceptable carrier package, the quality of every parcel is 6g.
The preparation method of the pharmacy particle agent of above-mentioned treatment cholelithiasis, the consumption of the preferred simple syrup of step (4) is the 5%-7% of thick paste quality, and the consumption being more preferably simple syrup is 6% of thick paste quality.
Instructions of taking: each 1 bag, every day 3 times, 2 days courses for the treatment of.
Technical advantage of the present invention is mainly reflected in:
1, the present invention adopts the preparation of pure natural medical material, and all meticulous compatibility forms, and drug effect is lastingly powerful, safe and reliable, does not injure the intestines and stomach, has no side effect, and can not produce drug dependence.
2, the present invention absorbs soon, good effect, short treating period, comprehensive killing pathogenic bacteria, controls gallbladder infection, effectively stops cholelithiasis regrowth.Simultaneously can lithodialysis rapidly, final calculus is smashed and is excreted, and function of gallbladder promoting diuresis, thoroughly cures cholelithiasis.
3, a large amount of clinical observation result shows, medicament of the present invention has depressed liver-energy dispersing and QI regulating, resolving depression Tongli, clearing away heat-damp and promoting diuresis, effect of blood stasis-eliminating and stagnation-dissipating, effectively promotes bile secretion, gallbladder shrinks under drug effect simultaneously, producing pressure makes calculus be shifted, and progressively pushes calculus to the total mouth of pipe, is conducive to the discharge of calculus.
4, selected materials great majority of the present invention are Chinese medicine material, and medical material is easy to get, and cost is low, and treatment cholelithiasis curative effect is outstanding, determined curative effect.
Detailed description of the invention
Describe technical scheme of the present invention in detail below in conjunction with embodiment and experimental example, but protection domain is not limited thereto.
embodiment 1the medicament for the treatment of cholelithiasis, takes off the primary raw material stating weight proportion and is prepared from (getting 40g for every part): 10 parts, Poria; Herba Dianthi 12 parts; Radix achyranthis asperae (Herba Achyranthis Asperae) 11 parts; Rhizoma Polygoni Cuspidati 7 parts; Herba clerodendranthi spicati 10 parts; Radix Curcumae 13 parts; Radix Ranunculi Ternati 10 parts; Fructus Toosendan 8 parts; Herba Centipedae 11 parts; Golden saxifrage 9 parts; Herba humuli scandentis 8 parts; Fructus Gardeniae 13 parts.
The preparation method of the medicament powder of above-mentioned treatment cholelithiasis, step is as follows:
(1) be placed in glass container by Rhizoma Polygoni Cuspidati, add yellow wine, mix thoroughly, moistening is sucked to wine, and load and steam in container, airtight, water proof heats 8 hours, takes out, dry, pulverize, and crosses 120 mesh sieves;
(2) pot is burnt heat, add Testa Tritici, continue to fry to when smoldering, add Poria, Fructus Toosendan and Fructus Gardeniae, constantly stir, moderate heat fries 35 minutes, takes out, and sieve removes Testa Tritici, dries in the air cool, pulverizes, and crosses 120 mesh sieves;
(3) Herba Dianthi, Radix achyranthis asperae (Herba Achyranthis Asperae), Herba clerodendranthi spicati, Radix Curcumae, Radix Ranunculi Ternati, Herba Centipedae, golden saxifrage and Herba humuli scandentis are placed in pot, moderate heat fried dry, pulverize, cross 140 mesh sieves;
(4) by step (1)-(3) gained fine powder mix homogeneously, sterile packaged is carried out by pharmaceutically accepted specification.
Instructions of taking: at every turn get 10g, is placed in tea bag, soaks, every day 3 times, 2 days courses for the treatment of by the warm waters of about 50 DEG C.
embodiment 2the medicament for the treatment of cholelithiasis, takes off the primary raw material stating weight proportion and is prepared from (every part of 20g): 17 parts, Poria; Herba Dianthi 16 parts; Radix achyranthis asperae (Herba Achyranthis Asperae) 15 parts; Rhizoma Polygoni Cuspidati 13 parts; Herba clerodendranthi spicati 13 parts; Radix Curcumae 18 parts; Radix Ranunculi Ternati 13 parts; Fructus Toosendan 12 parts; Herba Centipedae 14 parts; Golden saxifrage 12 parts; Herba humuli scandentis 8-13 part; Fructus Gardeniae 16 parts.
The preparation method of the medicament decoction of above-mentioned treatment cholelithiasis, step is as follows:
(1) be placed in glass container by Rhizoma Polygoni Cuspidati, add yellow wine, mix thoroughly, moistening is sucked to wine, and load and steam in container, airtight, water proof heats 8 hours, takes out, dry;
(2) pot is burnt heat, add Testa Tritici, continue to fry to when smoldering, add Poria, Fructus Toosendan and Fructus Gardeniae, constantly stir, moderate heat fries 35 minutes, takes out, and sieve removes Testa Tritici, dries in the air cool;
(3) cleaned by Radix Curcumae, section, is placed in glass container, adds Chinese liquor (consumption of Chinese liquor is 13% of Radix Curcumae quality), moistening, fried dry;
(4) by Herba Dianthi, Radix achyranthis asperae (Herba Achyranthis Asperae), Herba clerodendranthi spicati, Radix Ranunculi Ternati, Herba Centipedae, golden saxifrage and Herba humuli scandentis mixing, be placed in container, soak 50 minutes, be placed in marmite, add step (1)-(3) gains, decoct twice, each 35 minutes, filter, merging filtrate, be concentrated into 1/2 of original volume, obtain decoction.
Instructions of taking: each 80ml, every day 3 times, 2 days courses for the treatment of.
model case onesingle XX, man, 36 years old, Hebei province Langfang City people.Cholelithiasis has found more than 2 years, but never has obvious symptom.Start before half wheat harvesting period to occur right Upper abdominal pain, paroxysmal colic, about ensiform process of sternum, pain once in a while, gradually starts to take on to the right, back, left hand diffuses.The right Upper abdominal pain of frequent appearance is paroxysmal colic, companion's nausea and vomiting, is generally started pain after having sat of a specified duration.Sometimes also there will be dyspepsia.So to examination in hospital, B ultrasonic display cholelithiasis 16mm, gallbladder wall is crude, is diagnosed as cholelithiasis.Expectant treatment is after one week, and nothing is obviously alleviated.
After taking 2 courses for the treatment of of medicament decoction (embodiment 2) of gained of the present invention treatment cholelithiasis, stomachache obviously alleviates, and B ultrasonic display cholelithiasis obviously diminishes.After continuing to take 2 courses for the treatment of, all malaise symptoms disappear, and B ultrasonic shows cholelithiasis and disappears completely, reaches clinical cure.Tracing observation is learnt and is fully recovered, without recurrence.
embodiment 3the medicament for the treatment of cholelithiasis, takes off the primary raw material stating weight proportion and is prepared from (getting 30g for every part): 12 parts, Poria; Herba Dianthi 13 parts; Radix achyranthis asperae (Herba Achyranthis Asperae) 12 parts; Rhizoma Polygoni Cuspidati 9 parts; Herba clerodendranthi spicati 11 parts; Radix Curcumae 15 parts; Radix Ranunculi Ternati 11 parts; Fructus Toosendan 9 parts; Herba Centipedae 12 parts; Golden saxifrage 10 parts; Herba humuli scandentis 9 parts; Fructus Gardeniae 14 parts.
The preparation method of the medicament pill of above-mentioned treatment cholelithiasis, step is as follows:
(1) be placed in glass container by Rhizoma Polygoni Cuspidati, add yellow wine, mix thoroughly, moistening is sucked to wine, and load and steam in container, airtight, water proof heats 8 hours, takes out, dry;
(2) pot is burnt heat, add Testa Tritici, continue to fry to when smoldering, add Poria, Fructus Toosendan and Fructus Gardeniae, constantly stir, moderate heat fries 35 minutes, takes out, and sieve removes Testa Tritici, dries in the air cool;
(3) cleaned by Radix Curcumae, section, is placed in glass container, adds Chinese liquor (consumption of Chinese liquor is 13% of Radix Curcumae quality), moistening, fried dry;
(4) by Herba Dianthi, Radix achyranthis asperae (Herba Achyranthis Asperae), Herba clerodendranthi spicati, Radix Ranunculi Ternati, Herba Centipedae, golden saxifrage and Herba humuli scandentis mixing, be placed in container, soak 50 minutes, be placed in marmite, add step (1)-(3) gains, decoct twice, each 35 minutes, filter, merging filtrate, being concentrated into relative density is 1.15(25 DEG C) thick paste, make the pill that diameter is 4mm.
Instructions of taking: each 10 balls, every day 3 times, 2 days courses for the treatment of.
embodiment 4the medicament for the treatment of cholelithiasis, takes off the primary raw material stating weight proportion and is prepared from (getting 25g for every part): 15 parts, Poria; Herba Dianthi 15 parts; Radix achyranthis asperae (Herba Achyranthis Asperae) 14 parts; Rhizoma Polygoni Cuspidati 11 parts; Herba clerodendranthi spicati 12 parts; Radix Curcumae 17 parts; Radix Ranunculi Ternati 12 parts; Fructus Toosendan 11 parts; Herba Centipedae 13 parts; Golden saxifrage 11 parts; Herba humuli scandentis 12 parts; Fructus Gardeniae 15 parts.
The preparation method of the medicament tablet of above-mentioned treatment cholelithiasis, step is as follows:
(1) be placed in glass container by Rhizoma Polygoni Cuspidati, add yellow wine, mix thoroughly, moistening is sucked to wine, and load and steam in container, airtight, water proof heats 8 hours, takes out, dry;
(2) pot is burnt heat, add Testa Tritici, continue to fry to when smoldering, add Poria, Fructus Toosendan and Fructus Gardeniae, constantly stir, moderate heat fries 35 minutes, takes out, and sieve removes Testa Tritici, dries in the air cool;
(3) cleaned by Radix Curcumae, section, is placed in glass container, adds Chinese liquor (consumption of Chinese liquor is 13% of Radix Curcumae quality), moistening, fried dry;
(4) by Herba Dianthi, Radix achyranthis asperae (Herba Achyranthis Asperae), Herba clerodendranthi spicati, Radix Ranunculi Ternati, Herba Centipedae, golden saxifrage and Herba humuli scandentis mixing, be placed in container, soak 50 minutes, be placed in marmite, add step (1)-(3) gains, decoct twice, each 35 minutes, filter, merging filtrate, being concentrated into relative density is 1.15(25 DEG C) thick paste, make tablet.
Instructions of taking: each 2-3 sheet, every day 3 times, 2 days courses for the treatment of.
model case twoguo XX, female, 28 years old, people from Yantai City.Epigastric discomfort 2 wheat harvesting period, removes examination in hospital, finds that gallbladder has microlith through B ultrasonic, subsequently at hospital's row rubble, is with calculus medicine to go home calculus after rubble.Ten Tian Houqu hospital check B ultrasonic are shown in: have more muddy stone in gallbladder, move with displacement body, gallbladder wall is not thick.
After taking 2 courses for the treatment of of medicament tablet (embodiment 4) of gained of the present invention treatment cholelithiasis, symptom obviously alleviates, pain transference cure.After continuing to take 2 courses for the treatment of, check B ultrasonic: calculus disappears completely, and gallbladder no abnormality seen, reaches clinical cure.Later stage follows up a case by regular visits to and learns and fully recover, and gallbladder does not occur calculus more so far.
embodiment 5the medicament for the treatment of cholelithiasis, takes off the primary raw material stating weight proportion and is prepared from (getting 30g for every part): 13 parts, Poria; Herba Dianthi 14 parts; Radix achyranthis asperae (Herba Achyranthis Asperae) 13 parts; Rhizoma Polygoni Cuspidati 10 parts; Herba clerodendranthi spicati 11.5 parts; Radix Curcumae 16 parts; Radix Ranunculi Ternati 11.5 parts; Fructus Toosendan 10 parts; Herba Centipedae 12.5 parts; Golden saxifrage 10.5 parts; Herba humuli scandentis 11 parts; Fructus Gardeniae 14.5 parts.
The preparation method of the pharmacy particle agent of above-mentioned treatment cholelithiasis, step is as follows:
(1) be placed in glass container by Rhizoma Polygoni Cuspidati, add yellow wine, mix thoroughly, moistening is sucked to wine, loads and steams in container, airtight, when water proof heats 8, takes out, dry;
(2) pot is burnt heat, add Testa Tritici, continue to fry to when smoldering, add Poria, Fructus Toosendan and Fructus Gardeniae, constantly stir, moderate heat fries 35 minutes, takes out, and sieve removes Testa Tritici, dries in the air cool;
(3) cleaned by Radix Curcumae, section, is placed in glass container, adds Chinese liquor (consumption of Chinese liquor is 13% of Radix Curcumae quality), moistening, fried dry;
(4) by Herba Dianthi, Radix achyranthis asperae (Herba Achyranthis Asperae), Herba clerodendranthi spicati, Radix Ranunculi Ternati, Herba Centipedae, golden saxifrage and Herba humuli scandentis mixing, be placed in container, soak 50 minutes, be placed in marmite, add step (1)-(3) gains, decoct twice, each 35 minutes, filter, merging filtrate, being concentrated into relative density is 1.15(25 DEG C) thick paste, add simple syrup, mixing, makes uniform granule, be aided with pharmaceutically acceptable carrier package, the quality of every parcel is 6g.
Instructions of taking: each 1 bag, every day 3 times, 2 days courses for the treatment of.
The pharmacology of the present invention's main raw material of Chinese medicine used is as follows:
Poria: sweet in the mouth, light, property is put down.GUIXIN, lung, spleen, kidney channel.For the dry sclerotia of On Polyporaceae Poria.Have promoting diuresis to eliminate damp pathogen, invigorating the spleen for dissipating phlegm, mind tranquilizing and the heart calming, relieve internal heat anticancer effect.For edema oliguria, phlegm retention vertigo and palpitation, insufficiency of the spleen lack of appetite, have loose bowels in loose stool, irritability, palpitation with fear insomnia, dysuria, edema distension, phlegm retention cough with dyspnea, vomiting, and malignant histocytosis, has loose bowels, seminal emission, stranguria with turbid discharge, and palpitation with fear is forgetful.
Herba Dianthi: bitter in the mouth, cold in nature.GUIXIN, small intestine meridian.For the dry aerial parts of pinkwort Herba Dianthi or Dianthus chinensis.There is inducing diuresis for treating stranguria syndrome, effect that removing blood stasis stimulates the menstrual flow.For pyretic stranguria, stranguria with blood.Stranguria caused by urinary stone, urinary obstruction, drenches the puckery pain of drop, menstruation apolipsis.
Radix achyranthis asperae (Herba Achyranthis Asperae): bitter in the mouth, acid, cold nature.Return liver, lung, urinary bladder channel.For the herb of amaranthaceous plant coarse wool Radix Achyranthis Bidentatae.There is blood circulation promoting and blood stasis dispelling, inducing diuresis for treating stranguria syndrome, effect of clearing away heat and expelling pathogen in the exterior.For amenorrhea, dysmenorrhea, menoxenia, traumatic injury, rheumatic arthritis, gonorrhea, edema, damp-heat vaginal discharge, fever caused by exogenous pathogens, malaria, pharyngalgia, furuncle carbuncle.
Rhizoma Polygoni Cuspidati: mildly bitter flavor, cold nature.Return liver, gallbladder, lung meridian.For dry rhizome and the root of polygonaceae plant Rhizoma Polygoni Cuspidati.There is expelling wind and removing dampness, dissipating blood stasis analgesic therapy, effect of relieving cough and resolving phlegm.For arthralgia, jaundice due to damp-heat, amenorrhea ， mass in the abdomen, burn due to hot liquid or fire, injury from falling down, carbuncle sore tumefacting virus, cough with copious phlegm.
Herba clerodendranthi spicati: sweet in the mouth, bitter in the mouth, cool in nature.For the herb of Labiatae kidney Tea plant kidney tea.Containing triterpenes, flavonoid, volatile oil and other compositions.There is heat clearing away, diuresis, calculus removing effect.For acute and chronic nephritis, cystitis, lithangiuria, cholelithiasis, rheumatic arthritis.
Radix Curcumae: acrid in the mouth, hardship, cold in nature.Return liver, the heart, lung meridian.For the dried root of zingiberaceous plant RADIX CURCUMAE, Rhizoma Curcumae Longae, Guangxi zedoary or Rhizoma Curcumae.There is regulating qi to disperse stagnation, heart fire-clearing upset-relieving, effect of promoting the function of the gallbladder to alleviate jaundice.For amenorrhea dysmenorrhea, chest and abdomen swelling and pain, twinge, calentura coma, epilepsy is gone mad, jaundice dark coloured urine.
Radix Ranunculi Ternati: acrid in the mouth, sweet, warm in nature.Return liver, lung meridian.For tuber or the herb of Ranunculaceae ranunculus Seynuns Kugelann.Have and reduce phlegm, eliminating stagnation, effect of removing toxic substances.For scrofula, tuberculosis, furuncle, migraine, malaria, toothache, snake bite and insect sting.
Fructus Toosendan: bitter in the mouth, cold in nature.Return liver, small intestinal, urinary bladder channel.Another name is Fructus Toosendan, Fructus Toosendan, Fructus Toosendan are real.For the dry mature fruit of Meliaceae plant Fructus Toosendan, primary medicinal component is Fructus Toosendan element, alkaloid etc.There are soothing liver-QI promoting the circulation of QI to relieve pain, effect of anthelmintic.For the breast side of body, abdominal distention, colic, abdominal pain due to worm stagnation.Bitter cold is fallen and is let out, can clearing away liver-fire, let out hot and suffocating, promoting the circulation of QI to relieve pain.
Herba Centipedae: acrid in the mouth, warm in nature.Return lung, Liver Channel.For the dry herb of feverfew Herba Centipedae.There is clearing the nasal passage, effect of cough-relieving.For headche due to wind-cold, cough with copious phlegm, has a stuffy nose obstructed, nasal sinusitis watery nasal discharge.
Golden saxifrage: bitter in the mouth, cold in nature.For the herb of the golden waist of Saxifragaceae golden saxifrage platymiscium China.There is heat clearing away, diuresis, jaundice eliminating, calculus removing effect.For icterohepatitis, cystitis, Biliary Calculi.
Herba humuli scandentis: sweet in the mouth, hardship, cold in nature.For the herb of Moraceae humulus plants Herba humuli scandentis.Containing luteolin, glycoside, choline, agedoite and volatilization wet goods.There is heat-clearing and toxic substances removing, effect of inducing diuresis to remove edema.For pulmonary tuberculosis hectic fever, gastroenteritis, dysentery, cold, fever, dysuria, pyelonephritis, acute nephritis, cystitis, urinary system calculus; Carbuncle furuncle and phyma poison is controlled in external, eczema, venom.
Fructus Gardeniae: bitter in the mouth, cold in nature.GUIXIN, lung, tri-jiao channel.Another name SHANZHIZI etc.For the dry mature fruit of Maguireothamnus speciosus Fructus Gardeniae.There is pathogenic fire purging relieving restlessness, clearing away heat and promoting diuresis, effect of removing pathogenic heat from blood and toxic substance from the body.Vexed for calentura, yellow cellulitis dark coloured urine, blood strangury and dry pain, heat in blood tells nosebleed, conjunctival congestion and swelling pain, pathogenic fire,toxin and furuncles; External treatment bruise pain.
test examplein order to verify the curative effect of the medicament (embodiment 5) of gained of the present invention treatment cholelithiasis, do contrast test in April ,-2011 in June, 2009:
General data: screening 280 routine Patients with Cholelithiasis, wherein male patient 94 people, female patient 186 people; Minimal ages 25 years old, max age 63 years old, 44.5 years old mean age; 25-40 year 83 people, 41-50 year 103 people, 51-63 year 94 people, be divided into experimental group and matched group two groups (wherein experimental group 180 people at random, matched group 100 people), two groups are compared there was no significant difference (P > 0.05), have comparability in sex, age, the course of disease, state of an illness scoring etc.
Diagnostic criteria: 1. B ultrasonic display gallbladder intracystic stones, thickening of capsule wall of gallbladder, crude, gallbladder volume increase; 2. clinical main manifestations is right flank portion pain, can back porch back of the body radiation to the right, companion's abdominal distention, poor appetite, stomachache or gastric fullness, vexed anxiety etc., also only can not show as right flank portion feeling of distension and oppression discomfort, yellowish urine, lazy tired power, mood smooth etc.
Exclusion standard: 1. have the important organ dysfunction persons such as severe cardiac, liver, kidney; 2. gestation or women breast-feeding their children, allergic constitution person; 3. be associated with severe complication and be badly in need of operative treatment person, as perforation of gallbladder, acute diffuse peritonitis or Acute necrotising pancreatitis etc.; 4. ultrasound diagnosis prompting neck of gallbladder does not obviously block person; 5. Subtotal gastrectomy patient was.
Usage and dosage: experimental group takes the pharmacy particle agent of gained of the present invention treatment cholelithiasis, each 1 bag, every day 3 times, 2 days courses for the treatment of.Matched group uses other medicine (as DANSHU soft capsule, Ursodeoxycholic Acid Tablets etc.), wherein, and DANSHU soft capsule: oral, a 1-2 grain, 3 times on the one; Or follow the doctor's advice.Ursodeoxycholic Acid Tablets: be grown up oral: every day 8-10mg/kg, early, evening have meal time gradation give.The course for the treatment of is the shortest is 6 months, and after 6 months, ultrasound investigation and cholecystography can drug withdrawals without improver; Be partly dissolved as calculus is existing, continue to take medicine until calculus is dissolved completely.
Criterion of therapeutical effect: cure: the malaise symptoms such as epigastrium pain disappear, B is super to be checked without calculus shade in gallbladder, and gallbladder wall and contractile function recover normal, follow up a case by regular visits to and do not recur for 1 year.Effective: clinical symptoms and sign obviously alleviate, B ultrasonic confirms discharge section calculus, and gallbladder wall and contractile function obviously improve.Invalid: clinical symptoms and sign can have and to alleviate or unchanged, and B is super checks that calculus is without change.
4 courses for the treatment of of medication treatment, observe latter 3 months for the treatment of.The Comparison of therapeutic of the experimental group of the matched group taking other drug and the medicament (embodiment 5) taking gained of the present invention treatment cholelithiasis, result is as shown in table 1:
Table 1
As can be seen from Table 1, take the cure rate of the medicament of gained of the present invention treatment cholelithiasis up to 70%, effective percentage is up to 97.78%; And the cure rate taking other drug only 41%, effective percentage also only has 79%, and inefficiency is up to 21%.So the successful of the medicament of gained treatment cholelithiasis of the present invention is better than the effect of other drug.
It should be pointed out that detailed description of the invention is the more representational example of the present invention, obvious technical scheme of the present invention is not limited to above-described embodiment, can also have a lot of distortion.Those of ordinary skill in the art, with the present invention clear and definite disclosed or obtain undoubtedly according to the written description of file, the claimed scope of this patent all should be thought.
Claims (10)
1. treat the medicament of cholelithiasis, it is characterized in that, take off the primary raw material stating quality proportioning and be prepared from: Poria 10-17 part; Herba Dianthi 12-16 part; Radix achyranthis asperae (Herba Achyranthis Asperae) 11-15 part; Rhizoma Polygoni Cuspidati 7-13 part; Herba clerodendranthi spicati 10-13 part; Radix Curcumae 13-18 part; Radix Ranunculi Ternati 10-13 part; Fructus Toosendan 8-12 part; Herba Centipedae 11-14 part; Golden saxifrage 9-12 part; Herba humuli scandentis 8-13 part; Fructus Gardeniae 13-16 part.
2. medicament according to claim 1, is characterized in that, takes off the primary raw material stating quality proportioning and is prepared from: Poria 12-15 part; Herba Dianthi 13-15 part; Radix achyranthis asperae (Herba Achyranthis Asperae) 12-14 part; Rhizoma Polygoni Cuspidati 9-11 part; Herba clerodendranthi spicati 11-12 part; Radix Curcumae 15-17 part; Radix Ranunculi Ternati 11-12 part; Fructus Toosendan 9-11 part; Herba Centipedae 12-13 part; Golden saxifrage 10-11 part; Herba humuli scandentis 9-12 part; Fructus Gardeniae 14-15 part.
3. medicament according to claim 1, is characterized in that, takes off the primary raw material stating quality proportioning and is prepared from: 13 parts, Poria; Herba Dianthi 14 parts; Radix achyranthis asperae (Herba Achyranthis Asperae) 13 parts; Rhizoma Polygoni Cuspidati 10 parts; Herba clerodendranthi spicati 11.5 parts; Radix Curcumae 16 parts; Radix Ranunculi Ternati 11.5 parts; Fructus Toosendan 10 parts; Herba Centipedae 12.5 parts; Golden saxifrage 10.5 parts; Herba humuli scandentis 11 parts; Fructus Gardeniae 14.5 parts.
4., according to the arbitrary described medicament of claim 1-3, it is characterized in that, the preparation method of described powder, step is as follows:
(1) be placed in glass container by Rhizoma Polygoni Cuspidati, add yellow wine, mix thoroughly, moistening is sucked to wine, loading steams in container, airtight, and water proof heating 6-10 hour, takes out, dry, pulverize, excessively 100-140 mesh sieve (preferred 110-130 mesh sieve excessively, was more preferably 120 mesh sieves);
(2) pot is burnt heat, add Testa Tritici, continue to fry to when smoldering, add Poria, Fructus Toosendan and Fructus Gardeniae, constantly stir, moderate heat fries 30-40 minute, takes out, and sieve removes Testa Tritici, dry in the air cool, pulverize, excessively 100-140 mesh sieve (preferred 110-130 mesh sieve excessively, was more preferably 120 mesh sieves);
(3) Herba Dianthi, Radix achyranthis asperae (Herba Achyranthis Asperae), Herba clerodendranthi spicati, Radix Curcumae, Radix Ranunculi Ternati, Herba Centipedae, golden saxifrage and Herba humuli scandentis are placed in pot, moderate heat fried dry, pulverize, excessively 120-160 mesh sieve (preferred 130-150 mesh sieve excessively, was more preferably 140 mesh sieves);
(4) by step (1)-(3) gained fine powder mix homogeneously, sterile packaged is carried out by pharmaceutically accepted specification.
5. the preparation method of medicament powder according to claim 4, is characterized in that: the consumption of the preferred yellow wine of step (1) is the 20%-40% of Rhizoma Polygoni Cuspidati quality, and the consumption being more preferably yellow wine is 30% of Rhizoma Polygoni Cuspidati quality.
6., according to the arbitrary described medicament of claim 1-3, it is characterized in that, the preparation method of described decoction, step is as follows:
(1) be placed in glass container by Rhizoma Polygoni Cuspidati, add yellow wine, mix thoroughly, moistening is sucked to wine, loads and steams in container, airtight, and water proof heating 6-10 hour, takes out, dry;
(2) pot is burnt heat, add Testa Tritici, continue to fry to when smoldering, add Poria, Fructus Toosendan and Fructus Gardeniae, constantly stir, moderate heat fries 30-40 minute, takes out, and sieve removes Testa Tritici, dries in the air cool;
(3) cleaned by Radix Curcumae, section, is placed in glass container, adds Chinese liquor (consumption of preferred Chinese liquor is the 10%-15% of Radix Curcumae quality, and the consumption being more preferably Chinese liquor is 13% of Radix Curcumae quality), moistening, fried dry;
(4) by Herba Dianthi, Radix achyranthis asperae (Herba Achyranthis Asperae), Herba clerodendranthi spicati, Radix Ranunculi Ternati, Herba Centipedae, golden saxifrage and Herba humuli scandentis mixing, be placed in container, soak 40-60 minute, be placed in marmite, add step (1)-(3) gains, decoct twice, each 30-40 minute, filters, merging filtrate, be concentrated into 1/2 of original volume, obtain decoction.
7., according to the arbitrary described medicament of claim 1-3, it is characterized in that, the preparation method of described pill, step is as follows:
(1) be placed in glass container by Rhizoma Polygoni Cuspidati, add yellow wine, mix thoroughly, moistening is sucked to wine, loads and steams in container, airtight, and water proof heating 6-10 hour, takes out, dry;
(2) pot is burnt heat, add Testa Tritici, continue to fry to when smoldering, add Poria, Fructus Toosendan and Fructus Gardeniae, constantly stir, moderate heat fries 30-40 minute, takes out, and sieve removes Testa Tritici, dries in the air cool;
(3) cleaned by Radix Curcumae, section, is placed in glass container, adds Chinese liquor (consumption of preferred Chinese liquor is the 10%-15% of Radix Curcumae quality, and the consumption being more preferably Chinese liquor is 13% of Radix Curcumae quality), moistening, fried dry;
(4) by Herba Dianthi, Radix achyranthis asperae (Herba Achyranthis Asperae), Herba clerodendranthi spicati, Radix Ranunculi Ternati, Herba Centipedae, golden saxifrage and Herba humuli scandentis mixing, be placed in container, soak 40-60 minute, be placed in marmite, add step (1)-(3) gains, decoct twice, each 30-40 minute, filter, merging filtrate, being concentrated into relative density is 1.10-1.20(25 DEG C) thick paste, make pill (preferably make the pill that diameter is 3mm-5mm, be more preferably and make the pill that diameter is 4mm).
8., according to the arbitrary described medicament of claim 1-3, it is characterized in that, the preparation method of described tablet, step is as follows:
(1) be placed in glass container by Rhizoma Polygoni Cuspidati, add yellow wine, mix thoroughly, moistening is sucked to wine, loads and steams in container, airtight, and water proof heating 6-10 hour, takes out, dry;
(2) pot is burnt heat, add Testa Tritici, continue to fry to when smoldering, add Poria, Fructus Toosendan and Fructus Gardeniae, constantly stir, moderate heat fries 30-40 minute, takes out, and sieve removes Testa Tritici, dries in the air cool;
(3) cleaned by Radix Curcumae, section, is placed in glass container, adds Chinese liquor (consumption of preferred Chinese liquor is the 10%-15% of Radix Curcumae quality, and the consumption being more preferably Chinese liquor is 13% of Radix Curcumae quality), moistening, fried dry;
(4) by Herba Dianthi, Radix achyranthis asperae (Herba Achyranthis Asperae), Herba clerodendranthi spicati, Radix Ranunculi Ternati, Herba Centipedae, golden saxifrage and Herba humuli scandentis mixing, be placed in container, soak 40-60 minute, be placed in marmite, add step (1)-(3) gains, decoct twice, each 30-40 minute, filters, merging filtrate, being concentrated into relative density is 1.10-1.20(25 DEG C) thick paste, make tablet.
9., according to the arbitrary described medicament of claim 1-3, it is characterized in that, the preparation method of described granule, step is as follows:
(1) be placed in glass container by Rhizoma Polygoni Cuspidati, add yellow wine, mix thoroughly, moistening is sucked to wine, loads and steams in container, airtight, and water proof heating 6-10 hour, takes out, dry;
(2) pot is burnt heat, add Testa Tritici, continue to fry to when smoldering, add Poria, Fructus Toosendan and Fructus Gardeniae, constantly stir, moderate heat fries 30-40 minute, takes out, and sieve removes Testa Tritici, dries in the air cool;
(3) cleaned by Radix Curcumae, section, is placed in glass container, adds Chinese liquor (consumption of preferred Chinese liquor is the 10%-15% of Radix Curcumae quality, and the consumption being more preferably Chinese liquor is 13% of Radix Curcumae quality), moistening, fried dry;
(4) by Herba Dianthi, Radix achyranthis asperae (Herba Achyranthis Asperae), Herba clerodendranthi spicati, Radix Ranunculi Ternati, Herba Centipedae, golden saxifrage and Herba humuli scandentis mixing, be placed in container, soak 40-60 minute, be placed in marmite, add step (1)-(3) gains, decoct twice, each 30-40 minute, filters, merging filtrate, being concentrated into relative density is 1.10-1.20(25 DEG C) thick paste, add simple syrup, mixing, makes uniform granule, be aided with pharmaceutically acceptable carrier package, the quality of every parcel is 6g.
10. the preparation method of pharmacy particle agent according to claim 9, is characterized in that: the consumption of the preferred simple syrup of step (4) is the 5%-7% of thick paste quality, and the consumption being more preferably simple syrup is 6% of thick paste quality.
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| CN103585591A (en) * | 2013-11-28 | 2014-02-19 | 唐翔 | Traditional Chinese medicine for treating gallstones |
| CN104415285A (en) * | 2013-08-21 | 2015-03-18 | 韩刚 | Traditional Chinese medicine composition for treating gall stone and preparation method thereof |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104415285A (en) * | 2013-08-21 | 2015-03-18 | 韩刚 | Traditional Chinese medicine composition for treating gall stone and preparation method thereof |
| CN103585591A (en) * | 2013-11-28 | 2014-02-19 | 唐翔 | Traditional Chinese medicine for treating gallstones |
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