CN104800674A - Blood replenishing medicine composition and preparing method thereof - Google Patents

Abstract

The invention relates to a blood replenishing medicine composition and a preparing method thereof. The preparation is prepared from the following ingredients according to the mixture ratio: angelica, ophiopogon root, dates, milk veteh, radix-polygoni multiflori, cinnamon, mulberry fruit, fruit of glossy privet, raspberries, rhizoma atractylodis macrocephalae, pawpaw, liquorice, tuckahoe, dandelion, folium ilicis chinensis, frankincense, rehmanniae, lithospermum, wild jujube, myrrh, cassia twig, salvia miltiorrhiza, morinda officinalis, medlar, cortex albiziae and coix seeds. Various ingredients of the medicine are mutually matched and are coordinated to take effect, the cost is low, clinic use proves that the medicine has a good treatment effect on anemia, and the application prospects are wide.

Description

A kind of hematonic compositions and preparation method thereof

Technical field

The invention belongs to Chinese medicine field, be specifically related to a kind of hematonic compositions and preparation method thereof.

Background technology

Anemia refers to that human peripheral blood erythrocyte volume a surname is few, lower than a kind of common clinical symptoms of lower limit normal range.Because red blood cell volume measures more complicated, often clinically to replace with hemoglobin (Hb) concentration.The main cause that anemia occurs is: (1) iron deficiency; (2) EPO generates and reduces; (3) metabolic poison produces inhibitory action to erythrocytic breeding; (4) inflammatory factor accelerates to remove the erythrocyte of antibody or immune complex parcel in circulation, makes its lost of life; (5) in CKD patient body, active oxygen produces and increases and make erythrocyte easily haemolysis etc. occur.Clinical manifestation: (1) nervous system: giddy, tinnitus, headache, insomnia, dreaminess, hypomnesis, absent minded etc. is that anemic hypoxia causes symptom common caused by neural tissue damage.Can cry and scream during infantile anemia uneasy, restlessly even affects intelligent development.(2) skin mucosa: the main manifestations of pale skin, mucosa when being anemia.During anemia, body is regulated by neuro humor and carries out effective blood volume and redistribute, relatively secondary internal organs as skin, mucosa then blood supply reduce; In addition, because erythrocyte in unit volume blood and content of hemoglobin reduce, skin, mucosa color also can be caused thin out.Coarse, skin, mucosa when lacking gloss even to form ulcer be anemia another kind of performance, may be also relevant with the protopathy of anemia.Hemolytic anemia, particularly extravascular haemolytic anemia, can cause skin, mucosa xanthochromia.(3) respiratory circulatory system: 2, the 3-diphosphoglyceric acids (2,3-DPG) that during anemia, in erythrocyte, synthesis is more, to reduce the affinity of hemoglobin to oxygen, make oxygen dissociation curve move to right, tissue obtains more oxygen.Out of breath or dyspnea is mostly caused by respiratory center hypoxia or hypercapnia.Therefore anemia is without obvious performance, accelerated breathing only after activity, is caused to deepen and had palpitation, increased heart rate.Anemia is heavier, and activity is larger, and symptom is more obvious.During anemia, the even orthopnea even if tranquility also may be breathed hard.Long-term anemia, heart overload work and for hypoxgia, can anemic cardiopathy be caused, now not only have changes in heart rate, also can have arrhythmia and cardiac insufficiency.(4) stool rule and the change etc. of character, appear that abdominal part distension, appetite lower, in digestive system: during anemia, digestive gland secretion reduces even body of gland atrophy, and then cause that digestive function lowers, dyspepsia.Long-term chronic haemolysis can merge Biliary Calculi and splenomegaly.Iron deficiency anemia can swallow foreign body sensation or different from disease.Megaloblastic anemia or pernicious anemia can cause glossitis, atrophy of tongue, beefy tongue, mirror-like tongue etc.

The traditional Chinese medical science is thought, " all blood all belongs to the heart ", " middle Jiao is bullied extracting juice, change and red be meaning blood ", " source of blood is kidney, and vital essence is sufficient, and hundred normal pulse are smooth ".As can be seen here, the generating resource of blood is in essence-QI from water and grain, and people absorbs water paddy nutrient substance, absorbs the precise and tiny of ingesta, by gasification, become ying-qi by middle Jiao (taste).Spleen obtain heart-fire a surname fall help, be converted into essence, body fluid, a part for essence is stored in kidney, and to treat the use of biochemistry, another part obtains helping of heart-fire and is converted into blood, with the flourish buffings vital organs of the human body.In kidney, congenital essence obtains the essence-QI from water and grain day after tomorrow, absorbs the transpiration of life fire, is converted into marrow.Marrow obtains that the part of the body cavity below the umbilicus, housing the bladder, kidneys and bowels is burning hot ly to swash, and is divided into the seminal fluid of marrow, and seminal fluid is converted into blood for a surname of life fire steams again, defeated in body, thinks the use of physiology.

The generation of blood and regulate with the Zang-Fu relationship such as the heart, liver,spleen,kidney close, therefore the traditional Chinese medical science calls " the main blood of the heart, blood stored in the liver, the spleen governs the blood." and giving full play to of these functions, depend on again the fiery Wen Zhao of life of kidney.Therefore, the heart, liver,spleen,kidney function are weak, all can cause blood deficiency.And the formation of blood deficiency is nothing more than internal and external factor.Exopathogen six climate exopathogens and warm intrusion body, dive and irregularly go out, and deeply changes the machine of blood, cause fresh blood without life, this paathogenic factor and modern medicine said " bacteriological infection, protozoon, toxin generation haemolysis are disease " perfectly in harmony.In endogenous cause of ill, or forfeit one's integrity for seven emotions, or be improper diet, or form for losing blood, or be that natural endowment is not enough, or exaggerate for exhaustion due to sexual indulgence after being ill, or be pregnant imbalance, and cause the machine of hemopoietic to be obstructed; Or the machine of digestion is disorderly, indigestion, does not precise and tinyly become, and the disease of blood deficiency occurs.Visible in endogenous cause of ill with modern medicine said " lack hemopoietic raw material or hemopoietic organ's dysfunction, or chronic blood loss forming anemia " be consistent substantially.

Blood is tangible thing, and gas belongs to invisible use.The operation of blood depends on gas, thus have " qi being the governor of blood, the capable then blood of gas, blood being the material foundation of QI, blood to gas also to " theory.Blood is given birth to by gas, and gas also must have blood for depending on, its effect that is biochemical, motion of competence exertion.The two interdepends, and promotes mutually again, keeps relative equilibrium.If qi-blood disharmony, will cause a disease."Nei Jing" is said: " be therefore excess of QI leading to insufficiency of blood that the institute of blood is also the deficiency of vital energy." therefore, blood deficiency patient generally all has the deficiency of vital energy, this on Diagnosis and Treat all tool have very important significance.

Medicine at present clinically for enriching blood is a lot, but mostly there is the defects such as expensive, complex process, effect are not remarkable.

Summary of the invention

The object of this invention is to provide a kind for the treatment of both the principal and secondary aspects of a disease, have no side effect, safe ready, cheap pure Traditional Chinese medicine composition and preparation method thereof.

Present inventor is by the large quantity research of traditional medicine, think that anemia is caused by " asthenia ", the category such as " asthenia ", " impairment of the kidney caused by overstrain " can be belonged to, deficiency syndrome mingling with excess syndrome, deficiency in origin and excess in superficiality, be this with weakened body resistance, the domination of pathogen time that is mark, there are " void, the stasis of blood, wet, turbid " four large pathogenesis, the most key with deficiency of spleen and stomach.The traditional Chinese medical science focuses on spleen kidney for the treatment of renal anemia and lays equal stress on, and QI and blood is laid equal stress on, righting and eliminating evilly taking into account, temperature male wind-supplying kidney replenishing essence, benefiting QI for activating blood circulation hemopoietic.

For achieving the above object, the technical solution used in the present invention is as follows:

A kind of hematonic compositions, it is prepared by the raw material of following proportioning and obtains:

Radix Angelicae Sinensis, Radix Ophiopogonis, Fructus Jujubae, the Radix Astragali, Radix Polygoni Multiflori, Cortex Cinnamomi, Fructus Mori, Fructus Ligustri Lucidi, Fructus Rubi, the Rhizoma Atractylodis Macrocephalae, Fructus Chaenomelis, Radix Glycyrrhizae, Poria, Herba Taraxaci, Ilex purpurea Hassk.[I.chinensis Sims, Olibanum, Radix Rehmanniae, Radix Arnebiae (Radix Lithospermi), Semen Ziziphi Spinosae, Myrrha, Ramulus Cinnamomi, Radix Salviae Miltiorrhizae, Radix Morindae Officinalis, Fructus Lycii, Cortex Albiziae, Semen Coicis.

Preferably, a kind of hematonic compositions of the present invention, it is prepared by the raw material of following weight proportioning and obtains:

Radix Angelicae Sinensis 45 parts, Radix Ophiopogonis 45 parts, 45 parts, Fructus Jujubae, the Radix Astragali 45 parts, Radix Polygoni Multiflori 40 parts,

Cortex Cinnamomi 40 parts, Fructus Mori 40 parts, Fructus Ligustri Lucidi 40 parts, Fructus Rubi 35 parts, the Rhizoma Atractylodis Macrocephalae 35 parts,

Fructus Chaenomelis 35 parts, 35 parts, Radix Glycyrrhizae, 35 parts, Poria, Herba Taraxaci 30 parts, Ilex purpurea Hassk.[I.chinensis Sims 30 parts,

Olibanum 30 parts, Radix Rehmanniae 30 parts, Radix Arnebiae (Radix Lithospermi) 30 parts, Semen Ziziphi Spinosae 25 parts, Myrrha 25 parts,

Ramulus Cinnamomi 25 parts, Radix Salviae Miltiorrhizae 20 parts, Radix Morindae Officinalis 20 parts, Fructus Lycii 20 parts, Cortex Albiziae 20 parts, Semen Coicis 20 parts.

The preparation method of described pharmaceutical preparation is as follows:

Above-mentioned raw materials medicine is taken for subsequent use according to above-mentioned weight:

(1) get Radix Angelicae Sinensis, Radix Polygoni Multiflori, Fructus Mori, Fructus Rubi, Ilex purpurea Hassk.[I.chinensis Sims, Olibanum, Myrrha, Radix Salviae Miltiorrhizae, Radix Morindae Officinalis mix in described ratio, add the ethanol (volume ratio) relative to mixture 3 times of weight 95%, reflux, extract, 2 times, each 1 hour, extracting solution merges, and is concentrated into the clear paste that density is 1.25g/ml, 80 DEG C of oven dry, be ground into powder, be complex A;

(2) get surplus stock, add the soak by water 1 hour of 4 times of weight, collecting by filtration filtrate, it is the extractum of 1.2g/ml that filtrate decompression drying is obtained density, is ground into powder, is complex B;

(3) complex A, complex B are mixed, in incapsulating, prepare capsule.

Usage and dosage, each 0.5g, three times on the one three weeks is a course for the treatment of.

The present invention, by the raw material of Chinese medicine commonly used, through rational compatibility, has given full play to characteristic property and effect of each raw material self, has taken into account complementary action each other; Through each raw material synergism each other, its drug effect complements each other, and reaches best coupling each other; Thus make gained serve good tonifying liver, the kidney invigorating, spleen reinforcing warp, there is nourishing YIN and benefiting blood, invigorating the spleen and benefiting QI, effect of invigorating blood circulation of enriching blood, take continuously and have to body void, inappetence, anemia person effect of well enriching blood; Simultaneously, this product is had a sweet temper, can also to ventilate nourishing the stomach, have effect of mind tranquilizing and the heart calming, safety has no side effect, taking convenience, nurse one's health the inside function of human body better, human body is nursed one's health in all directions, reaches the object for the treatment of both the principal and secondary aspects of a disease, be applicable to that anemia is weak, neurasthenia, cardiopalmus, palpitation with a distress feeling, forgetful, anorexia is particular about food, the patient of sleep disorder.

The component of medicine of the present invention all adopts natural raw material of Chinese medicine, and its preparation is easy, and medicine source is extensive, and with low cost, it follows the prescriptions principle of the traditional Chinese medical science, and through clinical practice checking, it is reliably evident in efficacy, mild in medicine property and, there is not toxic and side effects, have a extensive future.

Detailed description of the invention

Embodiment 1

A kind of hematonic compositions, it is prepared by the raw material of following weight proportioning and obtains:

Radix Angelicae Sinensis 45 parts, Radix Ophiopogonis 45 parts, 45 parts, Fructus Jujubae, the Radix Astragali 45 parts, Radix Polygoni Multiflori 40 parts,

Cortex Cinnamomi 40 parts, Fructus Mori 40 parts, Fructus Ligustri Lucidi 40 parts, Fructus Rubi 35 parts, the Rhizoma Atractylodis Macrocephalae 35 parts,

Fructus Chaenomelis 35 parts, 35 parts, Radix Glycyrrhizae, 35 parts, Poria, Herba Taraxaci 30 parts, Ilex purpurea Hassk.[I.chinensis Sims 30 parts,

Olibanum 30 parts, Radix Rehmanniae 30 parts, Radix Arnebiae (Radix Lithospermi) 30 parts, Semen Ziziphi Spinosae 25 parts, Myrrha 25 parts,

Ramulus Cinnamomi 25 parts, Radix Salviae Miltiorrhizae 20 parts, Radix Morindae Officinalis 20 parts, Fructus Lycii 20 parts, Cortex Albiziae 20 parts, Semen Coicis 20 parts.

The preparation method of described pharmaceutical preparation is as follows:

Above-mentioned raw materials medicine is taken for subsequent use according to above-mentioned weight:

(1) get Radix Angelicae Sinensis, Radix Polygoni Multiflori, Fructus Mori, Fructus Rubi, Ilex purpurea Hassk.[I.chinensis Sims, Olibanum, Myrrha, Radix Salviae Miltiorrhizae, Radix Morindae Officinalis mix in described ratio, add the ethanol (volume ratio) relative to mixture 3 times of weight 95%, reflux, extract, 2 times, each 1 hour, extracting solution merges, and is concentrated into the clear paste that density is 1.25g/ml, 80 DEG C of oven dry, be ground into powder, be complex A;

(2) get surplus stock, add the soak by water 1 hour of 4 times of weight, collecting by filtration filtrate, it is the extractum of 1.2g/ml that filtrate decompression drying is obtained density, is ground into powder, is complex B;

(3) complex A, complex B are mixed, in incapsulating, prepare capsule.

Usage and dosage, each 0.5g, three times on the one three weeks is a course for the treatment of.

Embodiment 2

Toxicity test:

This experiment adopts healthy SD rat, drug dose gradient prepared by oral administration embodiment 1 is 0.01g/kg and 0.1g/kg, successive administration 30 days, during observing rat administration and after drug withdrawal, within 1 week, growth of animal state, movable diet, hematology, blood biochemical analysis, organs and tissues structure and routine urinalysis etc. all have no significant effect, and show that clinical drug safety is reliable.

Embodiment 3

Clinical efficacy is summed up:

General data, pharmaceutical preparation of the present invention is applied to clinical observation 98 example, all experimenters is divided into 2 groups, matched group and experimental group, often organizes 49, and two groups of cases through statistical analysis, have comparability in sex, age, the course of disease etc.

The diagnostic criteria that WHO in 1972 works out is thought and is diagnosed as anemia at area, sea level Hb lower than following level: 6 months to <6 year child 110g/L, 6 ~ 14 years old child 120g/L, adult male 130g/L, adult female 120g/L, anemia of pregnant woman 110g/L.It should be noted that occupy highlands resident for a long time hemoglobin normal value comparatively sea level resident for high; Gestation, hypoproteinemia, congestive heart failure, splenomegaly and macroglobulinemia time, plasma volume increases, even if now red blood cell volume is normal, but diluted because of blood, hemoglobin concentration reduces, and is easily misdiagnosed as anemia; When dewatering or the circulating blood volume such as to lose blood reduces, due to pachyemia, even if red blood cell volume is on the low side, but increase because of hemoglobin concentration, anemia is easily failed to pinpoint a disease in diagnosis.

Therapeutic Method, experimental group, give pharmaceutical preparation prepared by embodiment 1, each 0.5g, three times on the one three weeks is a course for the treatment of;

Matched group: give commercially available FUFANG EJIAO JIANG, one time 20 milliliters (measuring with the measuring cup be equipped with), 3 times on the one three weeks is a course for the treatment of.

Therapeutic evaluation

Cure: the weak all transference cures of anemia, the deficiency of vital energy, and make a definite diagnosis through doctor and fully recover;

Effective: the weak partial symptoms of anemia, the deficiency of vital energy disappears or takes a turn for the better;

Invalid: the weak all symptoms of anemia, the deficiency of vital energy are without any improvement, even more serious;

Recurrence: healing person again suffers from original disease in 6 months after drug withdrawal.

Test data statistical analysis

After test all terminates, by as shown in table 1 for test data statistical analysis:

	Number of cases	Cure	Effectively	Invalid	Recurrence	Total effective rate
							Matched group	49	15	19	12	3	70%
Experimental group	49	30	16	3	0	94％

As seen from the above table: cure rate and the total effective rate of experimental group are all obviously better than matched group, have significant difference.

Embodiment 4

Model case

Liu, female 33 years old, xerosis cutis after fertility, dried and withered hairs easily takes off, fatigue and weak, is off one's feed.Give 1 course for the treatment of of pharmaceutical preparation prepared by embodiment 1, complexion is improved, and skin improves; Advise after continuing to take 1 course for the treatment of, physical recovery is normal, and tired sense disappears, and complexion starts ruddy, and appetite is normal; Through detecting RBC number, packed cell volume and hemoglobin content before and after patient, the index of anemia character frontly abnormally transfers to normal by treating, and follows up a case by regular visits to and has no recurrence half a year.

What more than enumerate is only best specific embodiment of the present invention.Obviously, the invention is not restricted to above embodiment, many distortion can also be had.All distortion that those of ordinary skill in the art can directly derive from content disclosed by the invention or associate, all should think protection scope of the present invention.

The present invention is for the preparation of the pharmaceutical preparation dialectical dispenser on the basis of existing technology of anemia, compatibility is made mutually between the various composition of Chinese medicine, coordinate usefulness, with low cost, through clinical verification, there is good therapeutic effect to premenstrual tension syndrome, in the applicant's medical practice for many years, the case Numerous of curing, obtains good effect, has broad application prospects.

Claims (3)

1. a hematonic compositions, is characterized in that, described pharmaceutical composition is prepared by following raw material and obtains:

Radix Angelicae Sinensis, Radix Ophiopogonis, Fructus Jujubae, the Radix Astragali, Radix Polygoni Multiflori, Cortex Cinnamomi, Fructus Mori, Fructus Ligustri Lucidi, Fructus Rubi, the Rhizoma Atractylodis Macrocephalae, Fructus Chaenomelis, Radix Glycyrrhizae, Poria, Herba Taraxaci, Ilex purpurea Hassk.[I.chinensis Sims, Olibanum, Radix Rehmanniae, Radix Arnebiae (Radix Lithospermi), Semen Ziziphi Spinosae, Myrrha, Ramulus Cinnamomi, Radix Salviae Miltiorrhizae, Radix Morindae Officinalis, Fructus Lycii, Cortex Albiziae, Semen Coicis.

2. pharmaceutical composition according to claim 1, is characterized in that, described pharmaceutical composition is prepared by the raw material of following weight parts and obtains:

Radix Angelicae Sinensis 45 parts, Radix Ophiopogonis 45 parts, 45 parts, Fructus Jujubae, the Radix Astragali 45 parts, Radix Polygoni Multiflori 40 parts,

Cortex Cinnamomi 40 parts, Fructus Mori 40 parts, Fructus Ligustri Lucidi 40 parts, Fructus Rubi 35 parts, the Rhizoma Atractylodis Macrocephalae 35 parts,

Fructus Chaenomelis 35 parts, 35 parts, Radix Glycyrrhizae, 35 parts, Poria, Herba Taraxaci 30 parts, Ilex purpurea Hassk.[I.chinensis Sims 30 parts,

Olibanum 30 parts, Radix Rehmanniae 30 parts, Radix Arnebiae (Radix Lithospermi) 30 parts, Semen Ziziphi Spinosae 25 parts, Myrrha 25 parts,

Ramulus Cinnamomi 25 parts, Radix Salviae Miltiorrhizae 20 parts, Radix Morindae Officinalis 20 parts, Fructus Lycii 20 parts, Cortex Albiziae 20 parts, Semen Coicis 20 parts.

3. the pharmaceutical composition described in claim 1-2, is characterized in that, the preparation method of described pharmaceutical composition comprises the steps:

(1) Radix Angelicae Sinensis, Radix Polygoni Multiflori, Fructus Mori, Fructus Rubi, Ilex purpurea Hassk.[I.chinensis Sims, Olibanum, Myrrha, Radix Salviae Miltiorrhizae, Radix Morindae Officinalis is got, mixing, add the ethanol relative to mixture 3 times of weight 95%, reflux, extract, 2 times, each 1 hour, extracting solution merged, be concentrated into the clear paste that density is 1.25g/ml, 80 DEG C of oven dry, are ground into powder, are complex A;

(2) get surplus stock, add the soak by water 1 hour of 4 times of weight, collecting by filtration filtrate, it is the extractum of 1.2g/ml that filtrate decompression drying is obtained density, is ground into powder, is complex B;

(3) by complex A and complex B mix homogeneously and get final product.