CN104800620A - Chinese herbal compound preparation for treating pains and inhibited joint mobility caused by wind and chill pathogenic factors attacking human body as well as preparation method and application of Chinese herbal compound preparation - Google Patents
Chinese herbal compound preparation for treating pains and inhibited joint mobility caused by wind and chill pathogenic factors attacking human body as well as preparation method and application of Chinese herbal compound preparation Download PDFInfo
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Abstract
The invention discloses a Chinese herbal compound preparation. The Chinese herbal compound preparation is prepared from rabdosia megathyrsa, osmorhiza aristata, stems and leaves of woody hawksbeard, Chinese tamarisk twigs, twigs of Germany falsetamarisk, bark of hollowed wampee, root of citrusleaf glycosmis, scorzonera albicaulis bunge, chloranthus japonicus siebold, herb of ternateleaf tabdosia, greater selaginella, callicarpa longissima, leaves of sabina chinensis, root of Chinese wingleaf prickyash, stems and leaves of wild spikenard, lemongrass herb, micromelum integerrimum, leaves of Hongkong kumquat, stems of anderson ironweed and baical skullcap root. The Chinese herbal compound preparation is scientific and reasonable in proportion of medicines, and prescription is strict. An experiment result shows that the Chinese herbal compound preparation has good effects of wind dispelling, palsy relief, cold dispelling, pain relief, swelling and dampness elimination, blood stasis dissipating, meridian dredging, muscle relaxation, promotion of blood circulation and the like, can effectively treat joint function disturbance and has a good treatment effect on pains and inhibited joint mobility as well as stomachache, cough, headache and the like caused by the wind and chill pathogenic factors attacking the human body; the clinical cure rate is high, no remarkable adverse reactions are caused, and the medication safety is good.
Description
Technical field
The present invention relates to a kind of Traditional Chinese medicine compound composition, be specifically related to a kind of pain and the unfavorable Traditional Chinese medicine compound composition of joint motion and preparation method thereof application for the treatment of because pathogenic wind-cold invasion and attack body causes.
Background technology
Numbness disease is made a comment or criticism QI-insufficiency, the exopathogen such as wind, cold, wet, heat invasion and attack human body, numbness resistance meridians, QI-blood circulation is not smooth caused, there is pain, numbness with muscle, muscles and bones, joint, weigh, joint stuffiness, even arthroncus is scorching hot is the disease of main clinical manifestation.And clinical sick with limbs meridians numbness, be commonly encountered diseases, sickness rate is very high, and some is refractory very, seeks medical advice many in middle doctor.This type of disease incidence is about about 1-3% in the world.World Health Organization (WHO) is classified as key research projects.Drastically influence the quality of life of patient, and the Chinese medicine compound of the pain that causes for this kind of disease of prior art and articular instability is less.Being diagnosed as of this disease: 1, of all ages, the sex of characteristics of incidence primary disease, but between twenty and fifty and physical labourer, athlete and sports enthusiast are easy to suffer from.Meanwhile, the weight of morbidity is relevant with cold, humidity, fatigue and Changes in weather, solar term etc.2, clinical manifestation unexpected or lentamente conscious limbs joint myalgia, joint stuffiness be the symptomatology feature of primary disease, or migration is indefinite, aversion to wind and cold; Or pain is acute, meet cold what for, obtain hot, delay; Or weigh and pain, brothers are heavy, movable ineffective, and muscle is apathetic; Or limbs joint pain, sore spot is glad red scorching hot, spasm of muscles and vessels; Or joint severe pain, enlargement is out of shape, and also has continuous and bitterly, numbness more so, accompanies cardiopalmus, weak person.3, tongue fur pulse condition red tongue, tongue many whitens are common heavy tight, the heavy string of pulse condition, deep and slow, puckery.4, auxiliary examination laboratory and x-ray etc. inspections often contribute to the diagnosis of numbness disease.
The hormone caused due to the hormones Western medicine of Clinical practice relies on a lot, in addition hormone can cause the side effect such as femur head necrosis, so be necessary to develop a kind of cheapness, effective Drug therapy pathogenic wind-cold invasion and attack body is with pain and the unfavorable disease for main clinical manifestation of joint motion.
Therefore, necessary on the basis of prior art, development and design is a kind of treats because pathogenic wind-cold invasion and attack body is with pain and the unfavorable Traditional Chinese medicine compound composition for main clinical manifestation of joint motion and preparation method thereof.
Summary of the invention
Goal of the invention: the object of the invention is to solve the deficiencies in the prior art, there is provided that a kind of proportioning is scientific and reasonable, cost is low, side effect is little, take facility, there is effect of wind expelling stagnation removing, dispersing cold for relieving pain, detumescence damp eliminating, dissipating blood stasis dredging collateral, relaxing muscles and tendons to promote blood circulation, can be used for control because pathogenic wind-cold invasion and attack body is with pain and the unfavorable Traditional Chinese medicine compound composition for main clinical manifestation of joint motion.Another object of the present invention is to provide the preparation method and application of this Traditional Chinese medicine compound composition.
Technical scheme: in order to realize above object, the technical scheme that the present invention takes is:
Treat the pain because pathogenic wind-cold invasion and attack body causes and the unfavorable Traditional Chinese medicine compound composition of joint motion, it is made up of the raw material of following parts by weight:
Rabdosia megathyrsa (Die IS), Radix Osmorhizae Laxae, Cauls et Folium Crepidis Ligneae, Ramulus et Folium Tamaricis, Cacumen Myricariae Germanicae, Cortex Clausenae Excavatae, Radix Glycosmidis Citrifoliae, white stem Radix Scorzonerae austriacae, Herba Chloranthi Henryi (Herba Choranthi seu Lysimachiae), Herba Rabdosiae Ternifoliae, great Ye, Caulis te Folium Callicarpae Longissimae, Folium et cacumen sabinae chinensis, Radix Zanthoxyli Planispini, Serpentis hundred, Herba Cymbopogonis Citrari, Radix Micromeli Integerrimi, Folium Fortunellae Hindsii, Caulis Vernoniae Andersonii, Radix Scutellariae.
Preferably, above-described treatment is because of the pathogenic wind-cold invasion and attack pain that causes of body and the unfavorable Traditional Chinese medicine compound composition of joint motion, and it is made up of the raw material of following parts by weight:
Rabdosia megathyrsa (Die IS) 1 ~ 12 part, Radix Osmorhizae Laxae 1 ~ 3 part, Cauls et Folium Crepidis Ligneae 1 ~ 3 part, Ramulus et Folium Tamaricis 1 ~ 20 part, Cacumen Myricariae Germanicae 1 ~ 3 part, Cortex Clausenae Excavatae 1 ~ 10 part, Radix Glycosmidis Citrifoliae 1 ~ 8 part, white stem Radix Scorzonerae austriacae 1 ~ 5 part, Herba Chloranthi Henryi (Herba Choranthi seu Lysimachiae) 1 ~ 8 part, Herba Rabdosiae Ternifoliae 1 ~ 10 part, Herba Selaginellae Doederleinii 1 ~ 10 part, Caulis te Folium Callicarpae Longissimae 1 ~ 8 part, Folium et cacumen sabinae chinensis 1 ~ 7 part, Radix Zanthoxyli Planispini 1 ~ 10 part, Caulis et Folium Hyptidis suaveolentis 1 ~ 3 part, 1 ~ 5 part, Herba Cymbopogonis Citrari, Radix Micromeli Integerrimi 1 ~ 5 part, Folium Fortunellae Hindsii 1 ~ 5 part, Caulis Vernoniae Andersonii 0.1 ~ 0.5 part, Radix Scutellariae 2 ~ 3 parts.
Preferably, above-described treatment is because of the pathogenic wind-cold invasion and attack pain that causes of body and the unfavorable Traditional Chinese medicine compound composition of joint motion, and it is made up of the raw material of following parts by weight:
Rabdosia megathyrsa (Die IS) 9-12 part, Radix Osmorhizae Laxae 1-3 part, Cauls et Folium Crepidis Ligneae 1-3 part, Ramulus et Folium Tamaricis 10-20 part, Cacumen Myricariae Germanicae 1-3 part, Cortex Clausenae Excavatae 5-10 part, Radix Glycosmidis Citrifoliae 3-8 part, white stem Radix Scorzonerae austriacae 2-5 part, Herba Chloranthi Henryi (Herba Choranthi seu Lysimachiae) 3-8 part, Herba Rabdosiae Ternifoliae 3-10 part, Herba Selaginellae Doederleinii 5-10 part, Caulis te Folium Callicarpae Longissimae 3-8 part, Folium et cacumen sabinae chinensis 2-7 part, Radix Zanthoxyli Planispini 3-10 part, Caulis et Folium Hyptidis suaveolentis 1-3 part, Herba Cymbopogonis Citrari 2-5 part, Radix Micromeli Integerrimi 2-5 part, Folium Fortunellae Hindsii 1-5 part, Caulis Vernoniae Andersonii 0.1-0.3 part, Radix Scutellariae 2-3 part.
Preferably, above-described treatment is because of the pathogenic wind-cold invasion and attack pain that causes of body and the unfavorable Traditional Chinese medicine compound composition of joint motion, and it is made up of the raw material of following parts by weight:
Rabdosia megathyrsa (Die IS) 10-12 part, Radix Osmorhizae Laxae 2.5-3 part, Cauls et Folium Crepidis Ligneae 0.5-1 part, Ramulus et Folium Tamaricis 1-3 part, Cacumen Myricariae Germanicae 1-2 part, Cortex Clausenae Excavatae 1-3 part, Radix Glycosmidis Citrifoliae 0.5-2 part, white stem Radix Scorzonerae austriacae 1-2 part, Herba Chloranthi Henryi (Herba Choranthi seu Lysimachiae) 1-2 part, Herba Rabdosiae Ternifoliae 1-5 part, Herba Selaginellae Doederleinii 1-2 part, Caulis te Folium Callicarpae Longissimae 1-2 part, Folium et cacumen sabinae chinensis 1-2 part, Radix Zanthoxyli Planispini 0.5-1 part, Caulis et Folium Hyptidis suaveolentis 0.5-1 part, Herba Cymbopogonis Citrari 1-2 part, Radix Micromeli Integerrimi 1-3 part, Folium Fortunellae Hindsii 1-2 part, Caulis Vernoniae Andersonii 0.1-0.2 part, Radix Scutellariae 2-3 part.
Preferably, above-described treatment is because of the pathogenic wind-cold invasion and attack pain that causes of body and the unfavorable Traditional Chinese medicine compound composition of joint motion, and it is made up of the raw material of following parts by weight:
Rabdosia megathyrsa (Die IS) 1-5 gram, Radix Osmorhizae Laxae 0.5-1 gram, Cauls et Folium Crepidis Ligneae 0.5-1 gram, Ramulus et Folium Tamaricis 1-3 gram, Cacumen Myricariae Germanicae 1-2 gram, Cortex Clausenae Excavatae 1-3 gram, Radix Glycosmidis Citrifoliae 0.5-2 gram, white stem Radix Scorzonerae austriacae 1-2 gram, Herba Chloranthi Henryi (Herba Choranthi seu Lysimachiae) 1-2 gram, Herba Rabdosiae Ternifoliae 8-10 gram, Herba Selaginellae Doederleinii 1-2 gram, Caulis te Folium Callicarpae Longissimae 1-2 gram, Folium et cacumen sabinae chinensis 1-2 gram, Radix Zanthoxyli Planispini 8-10 gram, Caulis et Folium Hyptidis suaveolentis 0.5-1 gram, Herba Cymbopogonis Citrari 1-2 gram, Radix Micromeli Integerrimi 1-3 gram, Folium Fortunellae Hindsii 1-2 gram, Caulis Vernoniae Andersonii (poisonous) 0.2-0.5 gram, Radix Scutellariae 2-3 gram.
Preferably, above-described treatment is because of the pathogenic wind-cold invasion and attack pain that causes of body and the unfavorable Traditional Chinese medicine compound composition of joint motion, and it is made up of the raw material of following parts by weight:
Rabdosia megathyrsa (Die IS) 1-5 gram, Radix Osmorhizae Laxae 0.5-1 gram, Cauls et Folium Crepidis Ligneae 0.5-1 gram, Ramulus et Folium Tamaricis 1-3 gram, Cacumen Myricariae Germanicae 1-2 gram, Cortex Clausenae Excavatae 1-3 gram, Radix Glycosmidis Citrifoliae 0.5-2 gram, white stem Radix Scorzonerae austriacae 1-2 gram, Herba Chloranthi Henryi (Herba Choranthi seu Lysimachiae) 1-2 gram, Herba Rabdosiae Ternifoliae 8-10 gram, Herba Selaginellae Doederleinii 8-10 gram, Caulis te Folium Callicarpae Longissimae 1-2 gram, Folium et cacumen sabinae chinensis 1-2 gram, Radix Zanthoxyli Planispini 8-10 gram, Caulis et Folium Hyptidis suaveolentis 0.5-1 gram, Herba Cymbopogonis Citrari 1-2 gram, Radix Micromeli Integerrimi 1-3 gram, Folium Fortunellae Hindsii 3-5 gram, Caulis Vernoniae Andersonii (poisonous) 0.2-0.3 gram, Radix Scutellariae 2-3 gram.
Treatment of the present invention, because of the preparation method of the pathogenic wind-cold invasion and attack pain that causes of body and the unfavorable Traditional Chinese medicine compound composition of joint motion, comprises the following steps:
Step 1: by weight, get Rabdosia megathyrsa (Die IS), Radix Osmorhizae Laxae, Cauls et Folium Crepidis Ligneae, Ramulus et Folium Tamaricis, Cacumen Myricariae Germanicae, Cortex Clausenae Excavatae, Radix Glycosmidis Citrifoliae, white stem Radix Scorzonerae austriacae, Herba Chloranthi Henryi (Herba Choranthi seu Lysimachiae), Herba Rabdosiae Ternifoliae, Herba Selaginellae Doederleinii, Caulis te Folium Callicarpae Longissimae, Folium et cacumen sabinae chinensis, Radix Zanthoxyli Planispini, Caulis et Folium Hyptidis suaveolentis, Herba Cymbopogonis Citrari, Radix Micromeli Integerrimi, Folium Fortunellae Hindsii, Caulis Vernoniae Andersonii and Radix Scutellariae, remove impurity; Then be put in drying baker drying for subsequent use to constant weight, bake out temperature is at 45 ~ 55 DEG C;
Step 2: be then crushed to Powdered with pulverizer by dried for step 1 each raw material of Chinese medicine, crosses 40 mesh sieves, until all pulverizing medicinal materials is complete for subsequent use;
Step 3: get the raw material of Chinese medicine after sieving, adds 5 ~ 10% ethanol water supersound extraction of raw material of Chinese medicine weight 5 ~ 10 times of volumes, 2 ~ 3 times, and merge supersound extraction liquid, concentrating under reduced pressure obtains concentrated solution;
Step 4: get step 3 concentrated solution and pharmaceutically acceptable carrier prepares Chinese medicine preparation.
Preferably, above-described treatment is because of the preparation method of the pathogenic wind-cold invasion and attack pain that causes of body and the unfavorable Traditional Chinese medicine compound composition of joint motion, step 3: get the raw material of Chinese medicine after sieving, add the 5% ethanol water supersound extraction 3 times of raw material of Chinese medicine weight 5 times of volumes, each 1 ~ 3 hour, merge supersound extraction liquid, concentrating under reduced pressure obtains concentrated solution.
Preferably, above-described treatment is because of the preparation method of the pathogenic wind-cold invasion and attack pain that causes of body and the unfavorable Traditional Chinese medicine compound composition of joint motion, and described Chinese medicine preparation is oral liquid, granule, capsule, tablet, drop pill or soft capsule.
Treatment of the present invention application in preparation treatment muscle, muscles and bones or arthralgia or joint stuffiness medicine because of the pathogenic wind-cold invasion and attack pain that causes of body and the unfavorable Traditional Chinese medicine compound composition of joint motion.
The effects such as the present invention screens prescription by great many of experiments, and in prescription, Rabdosia megathyrsa (Die IS) has the cold expelling that induces sweat, expelling wind and removing dampness.Can be used for curing mainly wind and cold headache due to invasion of exogenous pathogens, cough, rheumatic arthralgia, numb limbs and tense tendons, joint joint stuffiness.
The Radix Osmorhizae Laxae selected in prescription has cold expelling to be delivered, the effects such as pain relieving.Cure mainly anemofrigid cold, headache, the diseases such as general aching.
Select Cauls et Folium Crepidis Ligneae to have the effects such as diaphoresis in prescription, have that to control diseases caused by exogenous pathogenic factor lossless, rheumatism bones and muscles pain.
Select Ramulus et Folium Tamaricis in prescription, there is dispelling wind, induce sweat, diuresis, the effects such as removing toxic substances.Have and control measles difficulty thoroughly, rubella itching over the body, flu, cough with asthma, rheumatic ostalgia.
Cacumen Myricariae Germanicae is selected to have rash of inducing sweat, the effects such as dispelling wind for relieving itching in prescription.There is treatment measles without adequate eruption; Rheumatic arthralgia and ringworm.
Cortex Clausenae Excavatae is selected to have expelling wind and cold, promoting the circulation of QI to relieve pain in prescription, the effects such as dehumidifying detumescence.Cure mainly cold, fever, malaria, stomachache, edema, rheumatic arthritis, fracture is controlled in external, bruise, eczema.
Select Radix Glycosmidis Citrifoliae to have expelling pathogenic wind from the body surface, transforming phlegm and dispersing accumulations, the effects such as dissipating blood stasis in prescription, cure mainly cold cough, abdominal pain due to retention of food, colicky, traumatic injury congestive edema, chilblain.
White stem Radix Scorzonerae austriacae is selected to have heat-clearing and toxic substances removing, expelling wind and removing dampness in prescription, the effect such as to relieving asthma.Can be used for treating cold, fever, asthma, mastitis, furuncle, arthralgia, herpes zoster.
Select Herba Chloranthi Henryi (Herba Choranthi seu Lysimachiae) to have in prescription to dispel the wind, dehumidifying, invigorates blood circulation, the effects such as dissipating blood stasis.Can be used for controlling cough due to wind and cold, rheumatic numbness, pain, menoxenia, traumatic consumptive injury.
Herba Rabdosiae Ternifoliae is selected to have expelling wind and cold in prescription, the effects such as reason of reducing phlegm is wet.Can be used for curing cold, cough, jaundice, rheumatism swells and ache, toothache, and knife injury is hemorrhage.
Select Herba Selaginellae Doederleinii to have in prescription to dispel the wind, cold expelling, detumescence, the effects such as cough-relieving.Can be used for controlling cough due to wind and cold, rheumatism, finger swell.
Caulis te Folium Callicarpae Longissimae is selected to have expelling wind and cold in prescription, effects such as sterilization of invigorating blood circulation.Can be used for dispelling the wind and dampness pathogens osteodynia, cough due to wind and cold, abdominal pain due to accumulation of cold, innominate toxic swelling, traumatic injury.
Folium et cacumen sabinae chinensis is selected to have expelling wind and cold, the effects such as promoting blood circulation and detoxication in prescription.Can be used for controlling anemofrigid cold, rheumatic arthritis, urticaria, toxic swelling from the beginning of.
Select Radix Zanthoxyli Planispini to have in prescription to dispel the wind, cold expelling, invigorates blood circulation, the effects such as pain relieving.Can be used for controlling headache flu, cough, vomit and diarrhoea, rheumatic arthritis, traumatic injury, toothache.
Caulis et Folium Hyptidis suaveolentis is selected to have the effect such as dispelling wind dissipating blood stasis, removing toxic substances analgesic therapy in prescription.Can be used for curing cold, rheumatism, eczema, traumatic injuries.
Herba Cymbopogonis Citrari is selected to have dispelling wind to relieve the exterior syndrome, the effects such as eliminating blood stasis and smoothing collaterals in prescription.Can be used for the headache that cures cold, stomachache, has loose bowels, rheumatic arthralgia, traumatic injury.
Radix Micromeli Integerrimi is selected to have dispelling wind, damp eliminating, warming middle-JIAO, the effects such as dissipating blood stasis in prescription.Can be used for curing cold, malaria, wind alunite arthralgia pain, stomachache, traumatic injury.
Folium Fortunellae Hindsii is selected to have lung qi dispersing in prescription; Cough-relieving; The effects such as dissipating blood stasis for subsidence of swelling.Can be used for treating cold cough; Pertussis; Traumatic injury.
Caulis Vernoniae Andersonii is selected to have expelling pathogenic wind from the body surface, the effects such as relaxing muscles and tendons to promote blood circulation in prescription.Can be used for curing cold, malaria, rheumatic arthralgia, traumatic injury, laryngalgia, toothache.
Radix Scutellariae is selected to have removing the relative excess fire in prescription, except damp and hot, hemostasis, antiabortive.Can be used for controlling high fever excessive thirst, cough due to lung-heat, damp-heat dysentery, jaundice, pyretic stranguria, tell, be defeated in battle, collapse, leak, conjunctival congestion and swelling pain, frequent fetal movement, carbuncle furuncle.
All medicines share above, have effect of wind expelling stagnation removing, dispersing cold for relieving pain, detumescence damp eliminating, dissipating blood stasis dredging collateral, relaxing muscles and tendons to promote blood circulation, may be used for treatment because pathogenic wind-cold invasion and attack body is with pain and the unfavorable disease for main clinical manifestation of joint motion.
When the raw extract of Traditional Chinese medicine compound composition provided by the invention is made oral liquid, after each raw material is prepared into concentrated solution according to the method described above according to the number of different patient demand, add stabilizing agent and antiseptic that the upper acceptable of pharmaceutically preparation prepares oral liquid, make oral liquid.
When Traditional Chinese medicine compound composition raw extract provided by the invention is made tablet, after concentrated solution and lactose or corn starch mixing, add magnesium stearate when needing, tablet made by tabletting.
When Traditional Chinese medicine compound composition raw extract provided by the invention is made capsule, after concentrated solution and lactose or corn starch mixing, oven drying at low temperature, incapsulates rear radiation sterilization, incapsulates.
When Chinese medicine compound raw extract provided by the invention is made granule, after concentrated solution and lactose or xylitol mixing, be prepared into granule by comminutor, pouch encapsulates.
Beneficial effect: Traditional Chinese medicine compound composition provided by the invention is compared with existing technology and had the following advantages:
1. the present invention is according to the basic TCM theory of determination for the treatment of based on pathogenesis obtained through differentiation of symptoms and signs, according to pathogenic wind-cold invasion and attack body with pain and the unfavorable clinical manifestation of joint motion, optimize best prescription, Chinese medicine compound proportioning provided by the invention is scientific and reasonable, medication is rigorous, experimental result shows, Chinese medicine compound provided by the invention has good wind expelling stagnation removing, dispersing cold for relieving pain, detumescence damp eliminating, dissipating blood stasis dredging collateral, effect of relaxing muscles and tendons to promote blood circulation, effectively can improve joint function disturbance, to pain and joint motion is unfavorable has good therapeutic effect, and to the stomachache that pathogenic wind-cold invasion and attack body causes, cough, headache, there is good therapeutic effect good, clinical cure rate is high, untoward reaction is low, clinical drug safety is good.
2. the preparation method of Traditional Chinese medicine compound composition provided by the invention, whole technological design is reasonable, according to the physicochemical property of each flavour of a drug, filter out optimum extraction process, extract the extract active constituent content obtained high, pharmacologically active is stronger, impurity is few, the advantages such as untoward reaction is low, and conveniently can be prepared into clinical various preparation, taking convenience.
Detailed description of the invention
Below in conjunction with specific embodiment, illustrate the present invention further, these embodiments should be understood only be not used in for illustration of the present invention and limit the scope of the invention, after having read the present invention, the amendment of those skilled in the art to the various equivalent form of value of the present invention has all fallen within the application's claims limited range.
Embodiment 1
1, stagnate the headache caused in three YANG meridians for wind-cold damp pathogen, comprise headache, and whole head diffusivity pain, take following Traditional Chinese medicine compound composition provided by the invention, effective percentage is more than 90%.Traditional Chinese medicine compound composition provided by the invention, is made up of the raw material of following parts by weight: Rabdosia megathyrsa (Die IS) 10-12 gram, Radix Osmorhizae Laxae 2.5-3 gram, Cauls et Folium Crepidis Ligneae 0.5-1 gram, Ramulus et Folium Tamaricis 1-3 gram, Cacumen Myricariae Germanicae 1-2 gram, Cortex Clausenae Excavatae 1-3 gram, Radix Glycosmidis Citrifoliae 0.5-2 gram, white stem Radix Scorzonerae austriacae 1-2 gram, Herba Chloranthi Henryi (Herba Choranthi seu Lysimachiae) 1-2 gram, Herba Rabdosiae Ternifoliae 1-5 gram, Herba Selaginellae Doederleinii 1-2 gram, Caulis te Folium Callicarpae Longissimae 1-2 gram, Folium et cacumen sabinae chinensis 1-2 gram, Radix Zanthoxyli Planispini 0.5-1 gram, Caulis et Folium Hyptidis suaveolentis 0.5-1 gram, Herba Cymbopogonis Citrari 1-2 gram, Radix Micromeli Integerrimi 1-3 gram, Folium Fortunellae Hindsii 1-2 gram, Caulis Vernoniae Andersonii 0.1-0.2 gram, Radix Scutellariae 2-3 gram.
2, the preparation method of Traditional Chinese medicine compound composition of the present invention, comprises the following steps:
Step 1: get Rabdosia megathyrsa (Die IS) 10-12 gram, Radix Osmorhizae Laxae 2.5-3 gram, Cauls et Folium Crepidis Ligneae 0.5-1 gram, Ramulus et Folium Tamaricis 1-3 gram, Cacumen Myricariae Germanicae 1-2 gram, Cortex Clausenae Excavatae 1-3 gram, Radix Glycosmidis Citrifoliae 0.5-2 gram, white stem Radix Scorzonerae austriacae 1-2 gram, Herba Chloranthi Henryi (Herba Choranthi seu Lysimachiae) 1-2 gram, Herba Rabdosiae Ternifoliae 1-5 gram, Herba Selaginellae Doederleinii 1-2 gram, Caulis te Folium Callicarpae Longissimae 1-2 gram, Folium et cacumen sabinae chinensis 1-2 gram, Radix Zanthoxyli Planispini 0.5-1 gram, Caulis et Folium Hyptidis suaveolentis 0.5-1 gram, Herba Cymbopogonis Citrari 1-2 gram, Radix Micromeli Integerrimi 1-3 gram, Folium Fortunellae Hindsii 1-2 gram, Caulis Vernoniae Andersonii 0.1-0.2 gram, Radix Scutellariae 2-3 gram, remove impurity; Then be put in drying baker drying for subsequent use to constant weight, bake out temperature is at 50 DEG C;
Step 2: be then crushed to Powdered with pulverizer by dried for step 1 each raw material of Chinese medicine, crosses 40 mesh sieves, until all pulverizing medicinal materials is complete for subsequent use;
Step 3: get the raw material of Chinese medicine after sieving, the volumetric concentration adding raw material of Chinese medicine weight 5 times of volumes is 5% ethanol water supersound extraction 3 times, and within each 2 hours, merge supersound extraction liquid, concentrating under reduced pressure obtains concentrated solution; After getting concentrated solution and lactose or corn starch mixing, add magnesium stearate when needing, tablet made by tabletting.
Embodiment 2
1, stagnate the toothache caused in the large intesting channel of Hand-Yangming and the stomach channel of foot-Yang-ming for wind-cold damp pathogen, take following Traditional Chinese medicine compound composition provided by the invention, effective percentage is more than 88%.Traditional Chinese medicine compound composition provided by the invention, is made up of the medicine of following parts by weight: Rabdosia megathyrsa (Die IS) 1-5 gram, Radix Osmorhizae Laxae 0.5-1 gram, Cauls et Folium Crepidis Ligneae 0.5-1 gram, Ramulus et Folium Tamaricis 1-3 gram, Cacumen Myricariae Germanicae 1-2 gram, Cortex Clausenae Excavatae 1-3 gram, Radix Glycosmidis Citrifoliae 0.5-2 gram, white stem Radix Scorzonerae austriacae 1-2 gram, Herba Chloranthi Henryi (Herba Choranthi seu Lysimachiae) 1-2 gram, Herba Rabdosiae Ternifoliae 8-10 gram, Herba Selaginellae Doederleinii 1-2 gram, Caulis te Folium Callicarpae Longissimae 1-2 gram, Folium et cacumen sabinae chinensis 1-2 gram, Radix Zanthoxyli Planispini 8-10 gram, Caulis et Folium Hyptidis suaveolentis 0.5-1 gram, Herba Cymbopogonis Citrari 1-2 gram, Radix Micromeli Integerrimi 1-3 gram, Folium Fortunellae Hindsii 1-2 gram, Caulis Vernoniae Andersonii 0.2-0.5 gram, Radix Scutellariae 2-3 gram.
2, the preparation method of Traditional Chinese medicine compound composition of the present invention, comprises the following steps:
Step 1: get Rabdosia megathyrsa (Die IS) 1-5 gram, Radix Osmorhizae Laxae 0.5-1 gram, Cauls et Folium Crepidis Ligneae 0.5-1 gram, Ramulus et Folium Tamaricis 1-3 gram, Cacumen Myricariae Germanicae 1-2 gram, Cortex Clausenae Excavatae 1-3 gram, Radix Glycosmidis Citrifoliae 0.5-2 gram, white stem Radix Scorzonerae austriacae 1-2 gram, Herba Chloranthi Henryi (Herba Choranthi seu Lysimachiae) 1-2 gram, Herba Rabdosiae Ternifoliae 8-10 gram, Herba Selaginellae Doederleinii 1-2 gram, Caulis te Folium Callicarpae Longissimae 1-2 gram, Folium et cacumen sabinae chinensis 1-2 gram, Radix Zanthoxyli Planispini 8-10 gram, Caulis et Folium Hyptidis suaveolentis 0.5-1 gram, Herba Cymbopogonis Citrari 1-2 gram, Radix Micromeli Integerrimi 1-3 gram, Folium Fortunellae Hindsii 1-2 gram, Caulis Vernoniae Andersonii 0.2-0.5 gram, Radix Scutellariae 2-3 gram, remove impurity; Then be put in drying baker drying for subsequent use to constant weight, bake out temperature is at 55 DEG C;
Step 2: be then crushed to Powdered with pulverizer by dried for step 1 each raw material of Chinese medicine, crosses 40 mesh sieves, until all pulverizing medicinal materials is complete for subsequent use;
Step 3: get the raw material of Chinese medicine after sieving, the volumetric concentration adding raw material of Chinese medicine weight 10 times of volumes is 5% ethanol water supersound extraction 2 times, and within each 3 hours, merge supersound extraction liquid, concentrating under reduced pressure obtains concentrated solution; After concentrated solution and lactose or corn starch mixing, oven drying at low temperature, incapsulates rear radiation sterilization, incapsulates, obtained capsule.
Embodiment 3
1, stagnate the cough caused in passages through which vital energy circulates for wind-cold damp pathogen, be not limited to Meridian Tropism of Herbal Drugs, because " vital organs of the human body all make us coughing, and non-only lung also ".Take following Traditional Chinese medicine compound composition provided by the invention, effective percentage is more than 80%.Traditional Chinese medicine compound composition provided by the invention, is made up of the medicine of following parts by weight: Rabdosia megathyrsa (Die IS) 1-5 gram, Radix Osmorhizae Laxae 0.5-1 gram, Cauls et Folium Crepidis Ligneae 0.5-1 gram, Ramulus et Folium Tamaricis 1-3 gram, Cacumen Myricariae Germanicae 1-2 gram, Cortex Clausenae Excavatae 1-3 gram, Radix Glycosmidis Citrifoliae 0.5-2 gram, white stem Radix Scorzonerae austriacae 1-2 gram, Herba Chloranthi Henryi (Herba Choranthi seu Lysimachiae) 1-2 gram, Herba Rabdosiae Ternifoliae 8-10 gram, Herba Selaginellae Doederleinii 8-10 gram, Caulis te Folium Callicarpae Longissimae 1-2 gram, Folium et cacumen sabinae chinensis 1-2 gram, Radix Zanthoxyli Planispini 8-10 gram, Caulis et Folium Hyptidis suaveolentis 0.5-1 gram, Herba Cymbopogonis Citrari 1-2 gram, Radix Micromeli Integerrimi 1-3 gram, Folium Fortunellae Hindsii 3-5 gram, Caulis Vernoniae Andersonii 0.2-0.3 gram, Radix Scutellariae 2-3 gram.
2, the preparation method of Traditional Chinese medicine compound composition of the present invention, comprises the following steps:
Step 1: get Rabdosia megathyrsa (Die IS) 1-5 gram, Radix Osmorhizae Laxae 0.5-1 gram, Cauls et Folium Crepidis Ligneae 0.5-1 gram, Ramulus et Folium Tamaricis 1-3 gram, Cacumen Myricariae Germanicae 1-2 gram, Cortex Clausenae Excavatae 1-3 gram, Radix Glycosmidis Citrifoliae 0.5-2 gram, white stem Radix Scorzonerae austriacae 1-2 gram, Herba Chloranthi Henryi (Herba Choranthi seu Lysimachiae) 1-2 gram, Herba Rabdosiae Ternifoliae 8-10 gram, Herba Selaginellae Doederleinii 8-10 gram, Caulis te Folium Callicarpae Longissimae 1-2 gram, Folium et cacumen sabinae chinensis 1-2 gram, Radix Zanthoxyli Planispini 8-10 gram, Caulis et Folium Hyptidis suaveolentis 0.5-1 gram, Herba Cymbopogonis Citrari 1-2 gram, Radix Micromeli Integerrimi 1-3 gram, Folium Fortunellae Hindsii 3-5 gram, Caulis Vernoniae Andersonii 0.2-0.3 gram, Radix Scutellariae 2-3 gram, remove impurity; Then be put in drying baker drying for subsequent use to constant weight, bake out temperature is at 50 DEG C;
Step 2: be then crushed to Powdered with pulverizer by dried for step 1 each raw material of Chinese medicine, crosses 40 mesh sieves, until all pulverizing medicinal materials is complete for subsequent use;
Step 3: get the raw material of Chinese medicine after sieving, the volumetric concentration adding raw material of Chinese medicine weight 6 times of volumes is 8% ethanol water supersound extraction 3 times, and within each 1 hour, merge supersound extraction liquid, concentrating under reduced pressure obtains concentrated solution.After concentrated solution and lactose or xylitol mixing, be prepared into granule by comminutor, pouch encapsulates.
Embodiment 4
1, stagnate the stomachache caused in stomach for wind-cold damp pathogen, take following Traditional Chinese medicine compound composition provided by the invention, effective percentage is more than 85%.Traditional Chinese medicine compound composition provided by the invention, is made up of the medicine of following parts by weight: Rabdosia megathyrsa (Die IS) 1-3 gram, Radix Osmorhizae Laxae 0.5-1 gram, Cauls et Folium Crepidis Ligneae 0.5-1 gram, Ramulus et Folium Tamaricis 1-3 gram, Cacumen Myricariae Germanicae 1-2 gram, Cortex Clausenae Excavatae 8-10 gram, Radix Glycosmidis Citrifoliae 0.5-1 gram, white stem Radix Scorzonerae austriacae 3-5 gram, Herba Chloranthi Henryi (Herba Choranthi seu Lysimachiae) 1-2 gram, Herba Rabdosiae Ternifoliae 1-3 gram, Herba Selaginellae Doederleinii 0.5-1 gram, Caulis te Folium Callicarpae Longissimae 1-2 gram, Folium et cacumen sabinae chinensis 1-2 gram, Radix Zanthoxyli Planispini 8-10 gram, Caulis et Folium Hyptidis suaveolentis 0.5-1 gram, Herba Cymbopogonis Citrari 1-2 gram, Radix Micromeli Integerrimi 3-5 gram, Folium Fortunellae Hindsii 1-3 gram, Caulis Vernoniae Andersonii 0.1-0.2 gram, Radix Scutellariae 2-3 gram.Preparation method is with reference to the process of claims.
2, the preparation method of Traditional Chinese medicine compound composition of the present invention, comprises the following steps:
Step 1: get Rabdosia megathyrsa (Die IS) 1-3 gram, Radix Osmorhizae Laxae 0.5-1 gram, Cauls et Folium Crepidis Ligneae 0.5-1 gram, Ramulus et Folium Tamaricis 1-3 gram, Cacumen Myricariae Germanicae 1-2 gram, Cortex Clausenae Excavatae 8-10 gram, Radix Glycosmidis Citrifoliae 0.5-1 gram, white stem Radix Scorzonerae austriacae 3-5 gram, Herba Chloranthi Henryi (Herba Choranthi seu Lysimachiae) 1-2 gram, Herba Rabdosiae Ternifoliae 1-3 gram, Herba Selaginellae Doederleinii 0.5-1 gram, Caulis te Folium Callicarpae Longissimae 1-2 gram, Folium et cacumen sabinae chinensis 1-2 gram, Radix Zanthoxyli Planispini 8-10 gram, Caulis et Folium Hyptidis suaveolentis 0.5-1 gram, Herba Cymbopogonis Citrari 1-2 gram, Radix Micromeli Integerrimi 3-5 gram, Folium Fortunellae Hindsii 1-3 gram, Caulis Vernoniae Andersonii 0.1-0.2 gram, Radix Scutellariae 2-3 gram, remove impurity; Then be put in drying baker drying for subsequent use to constant weight, bake out temperature is at 50 DEG C;
Step 2: be then crushed to Powdered with pulverizer by dried for step 1 each raw material of Chinese medicine, crosses 40 mesh sieves, until all pulverizing medicinal materials is complete for subsequent use;
Step 3: get the raw material of Chinese medicine after sieving, the volumetric concentration adding raw material of Chinese medicine weight 10 times of volumes is 5% ethanol water supersound extraction 2 times, and within each 2 hours, merge supersound extraction liquid, concentrating under reduced pressure obtains concentrated solution.Concentrated solution will add stabilizing agent and antiseptic, oral liquid is made in sterilizing.
Embodiment 5
1, Traditional Chinese medicine compound composition provided by the invention, is made up of the medicine of following parts by weight: Rabdosia megathyrsa (Die IS) 6 parts, Radix Osmorhizae Laxae 2 parts, Cauls et Folium Crepidis Ligneae 2 parts, Ramulus et Folium Tamaricis 10 parts, Cacumen Myricariae Germanicae 2 parts, Cortex Clausenae Excavatae 5 parts, Radix Glycosmidis Citrifoliae 4 parts, white stem Radix Scorzonerae austriacae 3 parts, Herba Chloranthi Henryi (Herba Choranthi seu Lysimachiae) 4 parts, Herba Rabdosiae Ternifoliae 5 parts, Herba Selaginellae Doederleinii 5 parts, Caulis te Folium Callicarpae Longissimae 4 parts, Folium et cacumen sabinae chinensis 3 parts, Radix Zanthoxyli Planispini 5 parts, Caulis et Folium Hyptidis suaveolentis 2 parts, 3 parts, Herba Cymbopogonis Citrari, Radix Micromeli Integerrimi 3 parts, Folium Fortunellae Hindsii 3 parts, Caulis Vernoniae Andersonii 0.1 part, Radix Scutellariae 3 parts.
2, the preparation method of Traditional Chinese medicine compound composition of the present invention, comprises the following steps:
Step 1: get Rabdosia megathyrsa (Die IS) 6 parts, Radix Osmorhizae Laxae 2 parts, Cauls et Folium Crepidis Ligneae 2 parts, Ramulus et Folium Tamaricis 10 parts, Cacumen Myricariae Germanicae 2 parts, Cortex Clausenae Excavatae 5 parts, Radix Glycosmidis Citrifoliae 4 parts, white stem Radix Scorzonerae austriacae 3 parts, Herba Chloranthi Henryi (Herba Choranthi seu Lysimachiae) 4 parts, Herba Rabdosiae Ternifoliae 5 parts, Herba Selaginellae Doederleinii 5 parts, Caulis te Folium Callicarpae Longissimae 4 parts, Folium et cacumen sabinae chinensis 3 parts, Radix Zanthoxyli Planispini 5 parts, Caulis et Folium Hyptidis suaveolentis 2 parts, 3 parts, Herba Cymbopogonis Citrari, Radix Micromeli Integerrimi 3 parts, Folium Fortunellae Hindsii 3 parts, Caulis Vernoniae Andersonii 0.1 part, Radix Scutellariae 3 parts.Remove impurity; Then be put in drying baker drying for subsequent use to constant weight, bake out temperature is at 50 DEG C;
Step 2: be then crushed to Powdered with pulverizer by dried for step 1 each raw material of Chinese medicine, crosses 40 mesh sieves, until all pulverizing medicinal materials is complete for subsequent use;
Step 3: get the raw material of Chinese medicine after sieving, the volumetric concentration adding raw material of Chinese medicine weight 8 times of volumes is 5% ethanol water supersound extraction 3 times, and within each 1 hour, merge supersound extraction liquid, concentrating under reduced pressure obtains concentrate, makes granule.
Embodiment 6 clinical trial
1, clinical case: 287 examples are suffered from the patient of anemofrigid-damp arthralgia, 21-29 year person 7 example, account for 2.44%; 30-65 year person 189 example, account for 65.85%; 66-83 year person, 91 example, account for 31.7%.
2, test medicine: the Traditional Chinese medicine compound composition that the embodiment of the present invention 5 prepares.
3, the Traditional Chinese medicine compound composition that patient's clothes for patients that 287 examples suffer from anemofrigid-damp arthralgia prepares by the rear embodiment of the present invention 5, every day 2 times.287 examples are suffered from the patient of anemofrigid-damp arthralgia, arthralgia, joint stuffiness, aversion to wind, aversion to cold; Symptom all disappears, and anti-OAb is negative, cures 83 examples, cure rate 28.92%.Arthralgia alleviates, and joint stuffiness is alleviated, aversion to wind, and aversion to cold degree alleviates; Tongue Bai Weihou.Floating and tense pulse.Although few patients's arthroncus distortion exists, joint motions motility increases, and joint active exercise and passive exercise resistance reduce, effective 178 examples, effective percentage 62.02%.Nothing is clearly better or patient takes medicine because be unwilling to hold in drug administration process, so invalid 26 examples of drug use, accounts for 9.3%.
Specific experiment result is as shown in table 1:
Information slip before and after the routine patient suffering from anemofrigid-damp arthralgia of table 1:287
Above clinical trial results shows, Traditional Chinese medicine compound composition provided by the invention, employing determination for the treatment of based on pathogenesis obtained through differentiation of symptoms and signs is theoretical, in conjunction with anemofrigid-damp arthralgia pathogeny, best component proportioning is filtered out by great many of experiments, and preferably obtain best preparation technology by great many of experiments, Traditional Chinese medicine compound composition provided by the invention, there is wind expelling stagnation removing, dispersing cold for relieving pain, detumescence damp eliminating, dissipating blood stasis dredging collateral, the effects such as relaxing muscles and tendons to promote blood circulation, to the pathogenic wind-cold invasion and attack pain that causes of body and joint motion is unfavorable etc. that disease has good therapeutic effect, cure rate is high, and there are no obvious untoward reaction and toxic and side effects in experimentation, clinical drug safety is good.
The above is only the preferred embodiment of the present invention; it should be pointed out that for those skilled in the art, under the prerequisite not departing from the principle of the invention and design; can also make some improvements and modifications, these improvements and modifications also should be considered as protection scope of the present invention.
Claims (10)
1. treat the pain because pathogenic wind-cold invasion and attack body causes and the unfavorable Traditional Chinese medicine compound composition of joint motion, it is characterized in that, it is made up of following raw materials according:
Rabdosia megathyrsa (Die IS), Radix Osmorhizae Laxae, Cauls et Folium Crepidis Ligneae, Ramulus et Folium Tamaricis, Cacumen Myricariae Germanicae, Cortex Clausenae Excavatae, Radix Glycosmidis Citrifoliae, white stem Radix Scorzonerae austriacae, Herba Chloranthi Henryi (Herba Choranthi seu Lysimachiae), Herba Rabdosiae Ternifoliae, great Ye, Caulis te Folium Callicarpae Longissimae, Folium et cacumen sabinae chinensis, Radix Zanthoxyli Planispini, Serpentis hundred, Herba Cymbopogonis Citrari, Radix Micromeli Integerrimi, Folium Fortunellae Hindsii, Caulis Vernoniae Andersonii, Radix Scutellariae.
2. treatment according to claim 1 is because of the pathogenic wind-cold invasion and attack pain that causes of body and the unfavorable Traditional Chinese medicine compound composition of joint motion, and it is characterized in that, it is made up of the raw material of following parts by weight:
Rabdosia megathyrsa (Die IS) 1 ~ 12 part, Radix Osmorhizae Laxae 1 ~ 3 part, Cauls et Folium Crepidis Ligneae 1 ~ 3 part, Ramulus et Folium Tamaricis 1 ~ 20 part, Cacumen Myricariae Germanicae 1 ~ 3 part, Cortex Clausenae Excavatae 1 ~ 10 part, Radix Glycosmidis Citrifoliae 1 ~ 8 part, white stem Radix Scorzonerae austriacae 1 ~ 5 part, Herba Chloranthi Henryi (Herba Choranthi seu Lysimachiae) 1 ~ 8 part, Herba Rabdosiae Ternifoliae 1 ~ 10 part, Herba Selaginellae Doederleinii 1 ~ 10 part, Caulis te Folium Callicarpae Longissimae 1 ~ 8 part, Folium et cacumen sabinae chinensis 1 ~ 7 part, Radix Zanthoxyli Planispini 1 ~ 10 part, Caulis et Folium Hyptidis suaveolentis 1 ~ 3 part, 1 ~ 5 part, Herba Cymbopogonis Citrari, Radix Micromeli Integerrimi 1 ~ 5 part, Folium Fortunellae Hindsii 1 ~ 5 part, Caulis Vernoniae Andersonii 0.1 ~ 0.5 part, Radix Scutellariae 2 ~ 3 parts.
3. treatment according to claim 2 is because of the pathogenic wind-cold invasion and attack pain that causes of body and the unfavorable Traditional Chinese medicine compound composition of joint motion, and it is characterized in that, it is made up of the raw material of following parts by weight:
Rabdosia megathyrsa (Die IS) 9-12 part, Radix Osmorhizae Laxae 1-3 part, Cauls et Folium Crepidis Ligneae 1-3 part, Ramulus et Folium Tamaricis 10-20 part, Cacumen Myricariae Germanicae 1-3 part, Cortex Clausenae Excavatae 5-10 part, Radix Glycosmidis Citrifoliae 3-8 part, white stem Radix Scorzonerae austriacae 2-5 part, Herba Chloranthi Henryi (Herba Choranthi seu Lysimachiae) 3-8 part, Herba Rabdosiae Ternifoliae 3-10 part, Herba Selaginellae Doederleinii 5-10 part, Caulis te Folium Callicarpae Longissimae 3-8 part, Folium et cacumen sabinae chinensis 2-7 part, Radix Zanthoxyli Planispini 3-10 part, Caulis et Folium Hyptidis suaveolentis 1-3 part, Herba Cymbopogonis Citrari 2-5 part, Radix Micromeli Integerrimi 2-5 part, Folium Fortunellae Hindsii 1-5 part, Caulis Vernoniae Andersonii 0.1-0.3 part, Radix Scutellariae 2-3 part.
4. treatment according to claim 1 is because of the pathogenic wind-cold invasion and attack pain that causes of body and the unfavorable Traditional Chinese medicine compound composition of joint motion, and it is characterized in that, it is made up of the raw material of following parts by weight:
Rabdosia megathyrsa (Die IS) 10-12 part, Radix Osmorhizae Laxae 2.5-3 part, Cauls et Folium Crepidis Ligneae 0.5-1 part, Ramulus et Folium Tamaricis 1-3 part, Cacumen Myricariae Germanicae 1-2 part, Cortex Clausenae Excavatae 1-3 part, Radix Glycosmidis Citrifoliae 0.5-2 part, white stem Radix Scorzonerae austriacae 1-2 part, Herba Chloranthi Henryi (Herba Choranthi seu Lysimachiae) 1-2 part, Herba Rabdosiae Ternifoliae 1-5 part, Herba Selaginellae Doederleinii 1-2 part, Caulis te Folium Callicarpae Longissimae 1-2 part, Folium et cacumen sabinae chinensis 1-2 part, Radix Zanthoxyli Planispini 0.5-1 part, Caulis et Folium Hyptidis suaveolentis 0.5-1 part, Herba Cymbopogonis Citrari 1-2 part, Radix Micromeli Integerrimi 1-3 part, Folium Fortunellae Hindsii 1-2 part, Caulis Vernoniae Andersonii 0.1-0.2 part, Radix Scutellariae 2-3 part.
5. treatment according to claim 1 is because of the pathogenic wind-cold invasion and attack pain that causes of body and the unfavorable Traditional Chinese medicine compound composition of joint motion, and it is characterized in that, it is made up of the raw material of following parts by weight:
Rabdosia megathyrsa (Die IS) 1-5 gram, Radix Osmorhizae Laxae 0.5-1 gram, Cauls et Folium Crepidis Ligneae 0.5-1 gram, Ramulus et Folium Tamaricis 1-3 gram, Cacumen Myricariae Germanicae 1-2 gram, Cortex Clausenae Excavatae 1-3 gram, Radix Glycosmidis Citrifoliae 0.5-2 gram, white stem Radix Scorzonerae austriacae 1-2 gram, Herba Chloranthi Henryi (Herba Choranthi seu Lysimachiae) 1-2 gram, Herba Rabdosiae Ternifoliae 8-10 gram, Herba Selaginellae Doederleinii 1-2 gram, Caulis te Folium Callicarpae Longissimae 1-2 gram, Folium et cacumen sabinae chinensis 1-2 gram, Radix Zanthoxyli Planispini 8-10 gram, Caulis et Folium Hyptidis suaveolentis 0.5-1 gram, Herba Cymbopogonis Citrari 1-2 gram, Radix Micromeli Integerrimi 1-3 gram, Folium Fortunellae Hindsii 1-2 gram, Caulis Vernoniae Andersonii 0.2-0.5 gram, Radix Scutellariae 2-3 gram.
6. treatment according to claim 1 is because of the pathogenic wind-cold invasion and attack pain that causes of body and the unfavorable Traditional Chinese medicine compound composition of joint motion, and it is characterized in that, it is made up of the raw material of following parts by weight:
Rabdosia megathyrsa (Die IS) 1-5 gram, Radix Osmorhizae Laxae 0.5-1 gram, Cauls et Folium Crepidis Ligneae 0.5-1 gram, Ramulus et Folium Tamaricis 1-3 gram, Cacumen Myricariae Germanicae 1-2 gram, Cortex Clausenae Excavatae 1-3 gram, Radix Glycosmidis Citrifoliae 0.5-2 gram, white stem Radix Scorzonerae austriacae 1-2 gram, Herba Chloranthi Henryi (Herba Choranthi seu Lysimachiae) 1-2 gram, Herba Rabdosiae Ternifoliae 8-10 gram, Herba Selaginellae Doederleinii 8-10 gram, Caulis te Folium Callicarpae Longissimae 1-2 gram, Folium et cacumen sabinae chinensis 1-2 gram, Radix Zanthoxyli Planispini 8-10 gram, Caulis et Folium Hyptidis suaveolentis 0.5-1 gram, Herba Cymbopogonis Citrari 1-2 gram, Radix Micromeli Integerrimi 1-3 gram, Folium Fortunellae Hindsii 3-5 gram, Caulis Vernoniae Andersonii 0.2-0.3 gram, Radix Scutellariae 2-3 gram.
7. the treatment described in any one of claim 1 ~ 6, because of the preparation method of the pathogenic wind-cold invasion and attack pain that causes of body and the unfavorable Traditional Chinese medicine compound composition of joint motion, is characterized in that, comprises the following steps:
Step 1: by parts by weight described in any one of claim 1 ~ 6, get Rabdosia megathyrsa (Die IS), Radix Osmorhizae Laxae, Cauls et Folium Crepidis Ligneae, Ramulus et Folium Tamaricis, Cacumen Myricariae Germanicae, Cortex Clausenae Excavatae, Radix Glycosmidis Citrifoliae, white stem Radix Scorzonerae austriacae, Herba Chloranthi Henryi (Herba Choranthi seu Lysimachiae), Herba Rabdosiae Ternifoliae, Herba Selaginellae Doederleinii, Caulis te Folium Callicarpae Longissimae, Folium et cacumen sabinae chinensis, Radix Zanthoxyli Planispini, Caulis et Folium Hyptidis suaveolentis, Herba Cymbopogonis Citrari, Radix Micromeli Integerrimi, Folium Fortunellae Hindsii, Caulis Vernoniae Andersonii and Radix Scutellariae, remove impurity; Then be put in drying baker drying for subsequent use to constant weight, bake out temperature is at 45 ~ 55 DEG C;
Step 2: be then crushed to Powdered with pulverizer by dried for step 1 each raw material of Chinese medicine, crosses 40 mesh sieves, until all pulverizing medicinal materials is complete for subsequent use;
Step 3: get the raw material of Chinese medicine after sieving, adds 5 ~ 10% ethanol water supersound extraction of raw material of Chinese medicine weight 5 ~ 10 times of volumes, 2 ~ 3 times, and merge supersound extraction liquid, concentrating under reduced pressure obtains concentrated solution;
Step 4: get step 3 concentrated solution and pharmaceutically acceptable carrier prepares Chinese medicine preparation.
8. treatment according to claim 7 is because of the preparation method of the pathogenic wind-cold invasion and attack pain that causes of body and the unfavorable Traditional Chinese medicine compound composition of joint motion, it is characterized in that, step 3: get the raw material of Chinese medicine after sieving, add the 5% ethanol water supersound extraction 3 times of raw material of Chinese medicine weight 5 times of volumes, each 1 ~ 3 hour, merge supersound extraction liquid, concentrating under reduced pressure obtains concentrated solution.
9. treatment according to claim 7 is because of the preparation method of the pathogenic wind-cold invasion and attack pain that causes of body and the unfavorable Traditional Chinese medicine compound composition of joint motion, it is characterized in that, described Chinese medicine preparation is oral liquid, granule, capsule, tablet, drop pill or soft capsule.
10. the application in preparation treatment muscle, muscles and bones or arthralgia or joint stuffiness medicine because of the pathogenic wind-cold invasion and attack pain that causes of body and the unfavorable Traditional Chinese medicine compound composition of joint motion of the treatment described in any one of claim 1 to 6.
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| CN1135909A (en) * | 1995-12-18 | 1996-11-20 | 铁萱 | Medicine for hyperosteogeny and wind-cold syndrome |
| CN1704076A (en) * | 2004-06-02 | 2005-12-07 | 李正涛 | Wind expelling stagnation removing capsule |
| CN101406590A (en) * | 2008-11-28 | 2009-04-15 | 李庆茹 | Chinese medicinal composition for treating rheumatism osteonosus and preparation method |
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|---|---|---|---|---|
| CN1135909A (en) * | 1995-12-18 | 1996-11-20 | 铁萱 | Medicine for hyperosteogeny and wind-cold syndrome |
| CN1704076A (en) * | 2004-06-02 | 2005-12-07 | 李正涛 | Wind expelling stagnation removing capsule |
| CN101406590A (en) * | 2008-11-28 | 2009-04-15 | 李庆茹 | Chinese medicinal composition for treating rheumatism osteonosus and preparation method |
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Application publication date: 20150729 |