CN104799821B - Orthogonal sine wave frequency coding hyperspectral imaging measurement system applied to mammary gland - Google Patents
Orthogonal sine wave frequency coding hyperspectral imaging measurement system applied to mammary gland Download PDFInfo
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- CN104799821B CN104799821B CN201510200418.1A CN201510200418A CN104799821B CN 104799821 B CN104799821 B CN 104799821B CN 201510200418 A CN201510200418 A CN 201510200418A CN 104799821 B CN104799821 B CN 104799821B
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- monochromatic light
- light source
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- 238000005259 measurement Methods 0.000 title claims abstract description 25
- 210000005075 mammary gland Anatomy 0.000 title claims abstract description 24
- 238000000701 chemical imaging Methods 0.000 title claims abstract description 17
- 210000001519 tissue Anatomy 0.000 claims abstract description 20
- 238000003384 imaging method Methods 0.000 claims abstract description 17
- 230000005540 biological transmission Effects 0.000 claims abstract description 12
- 238000007689 inspection Methods 0.000 claims abstract description 4
- 238000000034 method Methods 0.000 claims abstract description 4
- 230000000149 penetrating effect Effects 0.000 claims abstract description 3
- 210000000481 breast Anatomy 0.000 claims description 17
- 238000005070 sampling Methods 0.000 claims description 10
- 239000004576 sand Substances 0.000 claims description 4
- 238000000926 separation method Methods 0.000 description 5
- 206010028980 Neoplasm Diseases 0.000 description 3
- 238000010586 diagram Methods 0.000 description 3
- 230000003287 optical effect Effects 0.000 description 2
- 230000009286 beneficial effect Effects 0.000 description 1
- 238000001514 detection method Methods 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 230000035515 penetration Effects 0.000 description 1
- 230000005855 radiation Effects 0.000 description 1
- 230000035945 sensitivity Effects 0.000 description 1
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/43—Detecting, measuring or recording for evaluating the reproductive systems
- A61B5/4306—Detecting, measuring or recording for evaluating the reproductive systems for evaluating the female reproductive systems, e.g. gynaecological evaluations
- A61B5/4312—Breast evaluation or disorder diagnosis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/0059—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence
- A61B5/0075—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence by spectroscopy, i.e. measuring spectra, e.g. Raman spectroscopy, infrared absorption spectroscopy
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/0059—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence
- A61B5/0082—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence adapted for particular medical purposes
- A61B5/0084—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence adapted for particular medical purposes for introduction into the body, e.g. by catheters
- A61B5/0086—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence adapted for particular medical purposes for introduction into the body, e.g. by catheters using infrared radiation
Abstract
The invention discloses an orthogonal sine wave frequency coding hyperspectral imaging measurement system applied to mammary glands, which comprises: the group of monochromatic light sources are distributed on one side of the mammary tissue, and the cameras are distributed on the other side of the mammary tissue; the monochromatic light sources in the group of monochromatic light sources are densely arranged on a set hemispherical surface and converged into a beam of light by a lens to form the light source; a camera constitutes a light source receiving device; the method comprises the following steps that orthogonal sine waves with different frequencies are adopted to drive each monochromatic light source in a group of monochromatic light sources respectively, and each pixel point in an image received by a camera is a monochromatic light combination of each monochromatic light source penetrating through a mammary gland; the computer separates the monochromatic light combination to obtain the contribution of each monochromatic light source in the monochromatic light combination, and accordingly the transmission hyperspectral imaging of the mammary gland is achieved. The invention realizes high-speed and high-information high-precision measurement of mammary gland transmission hyperspectral image imaging, has the advantages of low cost, convenient application and the like, and is suitable for frequent household self-inspection.
Description
Technical Field
The invention relates to the field of imaging measurement systems, in particular to an orthogonal sine wave frequency coding hyperspectral imaging measurement system applied to mammary glands.
Background
In the prior art, the inside of an object is imaged through light, particularly the inside of a human body, and the breast transmission imaging light measurement system has the outstanding advantages of no damage, no wound and no radiation, but the breast transmission imaging light measurement system which can be used in families is not used for regular tumor self-inspection so far, and the breast transmission imaging light measurement system has the reasons that the existing breast imaging measurement system is high in cost, complex in operation and limited in precision, and cannot meet the breast self-inspection requirement in practical application.
Disclosure of Invention
The invention provides an orthogonal sine wave frequency coding hyperspectral imaging measurement system applied to mammary gland, which realizes high-precision measurement of high-speed and large-information mammary gland transmitted light imaging, meets the requirements in practical application, and is described in detail as follows:
an orthogonal sine wave frequency encoded hyperspectral imaging measurement system for application to a breast, the imaging measurement system comprising: the device comprises a group of monochromatic light sources, a lens, a camera and a computer which is externally connected with the camera, wherein the group of monochromatic light sources and the lens are distributed on one side of a mammary gland, and the camera is distributed on the other side of the mammary gland;
wherein, each monochromatic source in a group of monochromatic sources is densely arranged on a set hemisphere, and is converged into a beam of light by a lens to form a light source; a camera constitutes a light source receiving device;
the method comprises the following steps that orthogonal sine waves with different frequencies are adopted to drive each monochromatic light source in a group of monochromatic light sources respectively, and each pixel point in an image received by a camera is a monochromatic light combination of each monochromatic light source penetrating through a mammary gland;
the computer separates the monochromatic light combination to obtain the contribution of each monochromatic light source in the monochromatic light combination, thereby realizing the imaging of the mammary gland.
The monochromatic light source and the camera are symmetrically arranged on two sides of the breast tissue sample.
Wherein the monochromatic light source is a laser diode.
In another embodiment, the monochromatic light source is a monochromatic diode.
In another embodiment, the camera is a mobile phone camera.
The technical scheme provided by the invention has the beneficial effects that: the device adopts orthogonal sine waves with different frequencies to drive the monochromatic light sources, separates photoelectric signals detected by the photosensitive device to obtain the contribution of each monochromatic light source in the monochromatic light combination, and further realizes the imaging of the breast tissue sample.
Drawings
FIG. 1 is a schematic diagram of a transmitted light imaging measurement system with orthogonal sine wave frequency coding applied to the mammary gland;
FIG. 2 is a schematic diagram of the relative positions of a monochromatic light source, breast tissue and a camera provided by the present invention;
fig. 3 is a schematic diagram of an orthogonal sine wave.
In the drawings, the components represented by the respective reference numerals are listed below:
1: a set of monochromatic light sources; 2: a lens;
3: a breast tissue sample; 4: a camera.
Detailed Description
In order to make the objects, technical solutions and advantages of the present invention more apparent, embodiments of the present invention are described in further detail below.
Example 1
An orthogonal sine wave frequency encoded hyperspectral imaging measurement system for application to the breast, see fig. 1 and 2, the transmitted light imaging measurement system comprising: a set of n monochromatic light sources 1 (LD)1…LDn) And a camera 4(CMOS or CCD), the wavelength of the monochromatic light source is 600-1200 nm, the wave band is an optical window, and the penetration depth is relatively deep.
Wherein, the specific value of n is related to the sensitivity of the breast sample 3 to different wavelengths, which is not limited in the embodiment of the present invention); a group of monochromatic light sources 1 are distributed on one side of a mammary tissue sample 3, and a camera 4 is distributed on the other side of the mammary tissue sample 3;
wherein each monochromatic light source LD in a group of monochromatic light sources 11…LDnThe light beams are densely arranged on a set hemispherical surface and converged into a beam of light by the lens 2 to form a linear array light source; one camera 4 constitutes a multi-wavelength light source receiving device. The linear array imaging light measuring system further comprises a computer (not shown in the figure) which is externally connected with one camera 4.
Referring to FIG. 3, the individual monochromatic light sources LD in a set of monochromatic light sources 1 are driven separately with orthogonal sine waves of different frequenciesiThe camera 4 collects images, and each pixel point is each monochromatic light source LDiCombination of monochromatic light I through a mammary tissue sample 3ij(ii) a Computer for monochromatic light combination IijThe separation can obtain monochromatic light combination IijEach of the monochromatic light sources LD iniThe contribution of (a) constitutes a transmission image at each wavelength. The transmitted light imaging measurement of the mammary gland is carried out according to the different optical characteristics of normal tissues, tumor tissues and the like in the mammary gland tissues under various wavelengths, so as to realize the early detection of the tumor.
Wherein, the computer combines the monochromatic light IijCarrying out the separationCan obtain monochromatic light combination IijEach of the monochromatic light sources LD iniThe contributing steps are specifically:
the method comprises the following steps:
1. suppose that the camera 4 is driven at the highest frequency f of the light emitting diode 1maxSampling the digital signal at 4M times the speed fs＝4M×fmaxAcquiring a sampling signal x (M), wherein M is a positive integer greater than or equal to 1;
2. microprocessing the sampling frequency fs＝4M×fmaxDownsampling by M times to 4 xfmax；
3. Based on the sampling signal x (m), the orthogonal reference sequence y generated by the microprocessor 1s(k) And yc(k) Calculating two orthogonal components RsAnd RC；
I.e. the highest frequency f is separatedmaxTwo quadrature sine wave modulated transmitted light signals.
4. Down-sampling the sampled signal x (m) by a factor of 2;
5. repeating the step 3 and the step 4, and continuously calculating two orthogonal components R of the signal with the frequency lower by halfsAnd RCUntil the transmitted light signal of the complete frequency is calculated and separated.
In the embodiment of the present invention, except for the specific description of the model of each device, the model of other devices is not limited, as long as the device can perform the above functions.
Example 2
Orthogonal sine wave frequency coding hyperspectral image composition applied to mammary glandImage measuring system, see fig. 1 and 2, this embodiment uses a laser diode as a monochromatic light source LD1…LDnThe description is given for the sake of example.
Driving each laser diode LD in a set of monochromatic light sources 1 with orthogonal sine waves of different frequenciesiEach pixel point in one camera 4 receives each laser diode LDiCombination of monochromatic light I through a mammary tissue sample 3ij(ii) a Computer for monochromatic light combination IijThe separation can obtain monochromatic light combination IijEach laser diode LD iniFrom which transmission hyperspectral imaging of the breast tissue sample 3 can be performed.
The computer processing steps in this embodiment are the same as those in embodiment 1, and are not described herein again.
In the embodiment of the present invention, except for the specific description of the model of each device, the model of other devices is not limited, as long as the device can perform the above functions.
Example 3
An orthogonal sine wave frequency coding hyperspectral imaging measurement applied to mammary gland is shown in figures 1 and 2, and the embodiment takes a monochromatic diode as a monochromatic light source LD1…LDnThe description is given for the sake of example.
Driving each of the monochromatic diodes LD of a set of monochromatic light sources 1 separately with orthogonal sine waves of different frequenciesiEach pixel point in one camera 4 receives each monochrome diode LDiCombination of monochromatic light I through a mammary tissue sample 3ij(ii) a Computer for monochromatic light combination IijThe separation can obtain monochromatic light combination IijEach of the single color diodes LD in (1)iFrom which transmission hyperspectral imaging of the breast tissue sample 3 can be performed.
The computer processing steps in this embodiment are the same as those in embodiment 1, and are not described herein again.
In the embodiment of the present invention, except for the specific description of the model of each device, the model of other devices is not limited, as long as the device can perform the above functions.
Example 4
An orthogonal sine wave frequency coding hyperspectral imaging measurement system applied to mammary gland is shown in fig. 1 and fig. 2, and the embodiment takes a laser diode as a monochromatic light source LD1…LDnThe camera of the mobile phone is described as an example of a camera.
Driving each of the monochromatic diodes LD of a set of monochromatic light sources 1 separately with orthogonal sine waves of different frequenciesiEach pixel point in one mobile phone camera 4 receives each laser diode LDiCombination of monochromatic light I through a mammary tissue sample 3ij(ii) a Computer for monochromatic light combination IijThe separation can obtain monochromatic light combination IijEach laser diode LD iniFrom which transmission hyperspectral imaging of the breast tissue sample 3 can be performed.
The computer processing steps in this embodiment are the same as those in embodiment 1, and are not described herein again.
In the embodiment of the present invention, except for the specific description of the model of each device, the model of other devices is not limited, as long as the device can perform the above functions.
Example 5
A transmission hyperspectral imaging light measurement system with orthogonal sine wave frequency coding of mammary gland is disclosed, referring to fig. 1 and fig. 2, and the embodiment takes a monochromatic diode as a monochromatic light source LD1…LDnThe camera of the mobile phone is described as an example of a camera.
Driving each of the monochromatic diodes LD of a set of monochromatic light sources 1 separately with orthogonal sine waves of different frequenciesiEach pixel point in one mobile phone camera 4 receives each monochrome diode LDiCombination of monochromatic light I through a mammary tissue sample 3ij(ii) a Computer for monochromatic light combination IijThe separation can obtain monochromatic light combination IijEach laser diode LD iniFrom which transmission hyperspectral imaging of the breast tissue sample 3 can be performed.
The computer processing steps in this embodiment are the same as those in embodiment 1, and are not described herein again.
In the embodiment of the present invention, except for the specific description of the model of each device, the model of other devices is not limited, as long as the device can perform the above functions.
Those skilled in the art will appreciate that the drawings are only schematic illustrations of preferred embodiments, and the above-described embodiments of the present invention are merely provided for description and do not represent the merits of the embodiments.
The above description is only for the purpose of illustrating the preferred embodiments of the present invention and is not to be construed as limiting the invention, and any modifications, equivalents, improvements and the like that fall within the spirit and principle of the present invention are intended to be included therein.
Claims (1)
1. An orthogonal sine wave frequency encoded hyperspectral imaging measurement system for application to a breast, the imaging measurement system comprising: the device comprises a group of monochromatic light sources, a camera and a computer, wherein the computer is externally connected with the camera, the group of monochromatic light sources are distributed on one side of a mammary gland tissue, the camera is distributed on the other side of the mammary gland tissue, and the wavelength of each monochromatic light source is 1200 nm; the system is suitable for home self-inspection;
wherein, each monochromatic light source in a group of monochromatic light sources is densely arranged on a hemispherical surface and converged into a beam of light by a lens to form the light source; a camera constitutes a light source receiving device;
the method comprises the following steps that orthogonal sine waves with different frequencies are adopted to drive each monochromatic light source in a group of monochromatic light sources respectively, and each pixel point in an image received by a camera is a monochromatic light combination of each monochromatic light source penetrating through a mammary gland;
the computer separates the monochromatic light combination to obtain the contribution of each monochromatic light source in the monochromatic light combination, so as to realize the transmission hyperspectral imaging of the mammary gland; the imaging measurement system realizes high-speed and high-information high-precision measurement of transmitted light imaging of the mammary gland;
the steps of separating the monochromatic light combination by the computer to obtain the contribution of each monochromatic light source in the monochromatic light combination are as follows:
1) suppose a camera to drive the highest frequency f of the light emitting diodesmaxSampling the digital signal at 4M times the speed fs＝4M×fmaxAcquiring a sampling signal x (M), wherein M is a positive integer greater than or equal to 1;
2) microprocessing the sampling frequency fs＝4M×fmaxDownsampling by M times to 4 xfmax；
3) Based on the sampling signal x (m), the orthogonal reference sequence y generated by the microprocessor 1s(k) And yc(k) Calculating two orthogonal components RsAnd RC；
I.e. the highest frequency f is separatedmaxTwo quadrature sine wave modulated transmitted light signals;
4) down-sampling the sampled signal x (m) by a factor of 2;
5) repeating the steps 3) and 4), and continuously calculating two orthogonal components R of the signal with the frequency lower by halfsAnd RCUntil the transmitted light signal of the complete frequency is calculated and separated;
the monochromatic light source is a laser diode; or, the monochromatic light source is a monochromatic diode;
the monochromatic light source and the camera are symmetrically arranged on two sides of the mammary tissue sample;
the camera is a mobile phone camera.
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| CN201510200418.1A CN104799821B (en) | 2015-04-23 | 2015-04-23 | Orthogonal sine wave frequency coding hyperspectral imaging measurement system applied to mammary gland |
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| CN201510200418.1A CN104799821B (en) | 2015-04-23 | 2015-04-23 | Orthogonal sine wave frequency coding hyperspectral imaging measurement system applied to mammary gland |
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| CN106361291A (en) * | 2016-10-20 | 2017-02-01 | 天津大学 | Preset level raised orthogonal sine wave frequency encoding hyperspectral imaging system |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| US4286602A (en) * | 1979-06-20 | 1981-09-01 | Robert Guy | Transillumination diagnostic system |
| EP1100371A1 (en) * | 1998-07-30 | 2001-05-23 | Yissum Research Development Company Of The Hebrew University Of Jerusalem | Optical mammography |
| CN100418477C (en) * | 2005-09-02 | 2008-09-17 | 深圳市国基科技有限公司 | Mammary gland blood oxygen function imaging method and system |
| CN101021478A (en) * | 2007-02-13 | 2007-08-22 | 江西农业大学 | Laser inducing fluorescent high spectral image detecting method and device for fruit quality |
| CN101049238B (en) * | 2007-05-11 | 2010-12-08 | 重庆伟联科技有限公司 | Two band infrared diagnosis instrument for disease of mammary gland |
| CN101849821B (en) * | 2010-06-13 | 2012-07-04 | 华中科技大学 | Optical fiber near-infrared spectrometer |
| CN102258365B (en) * | 2011-08-17 | 2014-04-09 | 天津大学 | Sine-wave modulation photo plethysmo graphy measuring device and method |
| CN102579012A (en) * | 2012-03-15 | 2012-07-18 | 天津大学 | Dynamic fluorescence-optical breast tomography device on basis of phase locking photon counting measurement |
| CN103385693A (en) * | 2012-05-09 | 2013-11-13 | 朱瑞龙 | Tumor imaging device |
| CN102920434B (en) * | 2012-10-23 | 2014-11-26 | 天津大学 | Fluorescence-optical combined tomography system and measuring method |
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