CN104798782B - Oxirane disinfection liquid and preparation and using method - Google Patents
Oxirane disinfection liquid and preparation and using method Download PDFInfo
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- CN104798782B CN104798782B CN201510182292.XA CN201510182292A CN104798782B CN 104798782 B CN104798782 B CN 104798782B CN 201510182292 A CN201510182292 A CN 201510182292A CN 104798782 B CN104798782 B CN 104798782B
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- oxirane
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Abstract
A kind of oxirane disinfection liquid and preparation and using method, this disinfectant solution is made up of solution A and B solution, and the effective ingredient of described solution A is: peracetic acid, citric acid, oxalic acid, and the effective ingredient of B solution is: parachlorometaxylenol, oxirane.Solution A and B solution are independent packaging, during use solution A and B solution by volume 2～4:1 mix homogeneously after use, the disinfectant solution of the present invention need not carry out in closed environment, is also not susceptible to the impact of ambient temperature and humidity.And the present invention is possible not only to carry out disinfection table top and can also carry out disinfection whole space.Use and environment and the person will not be damaged by production process, low price.
Description
Technical field
The present invention relates to a kind of disinfectant solution and preparation and using method, a kind of medical oxirane disappears
Venom and preparation and using method.
Background technology
Oxirane is inflammable and explosive toxic gas, and molecular formula is C2H4O, has the ether taste of fragrance, at 4 DEG C
Time relative density be 0.884, boiling point is 10.8 DEG C, and its density is 1.52g/cm3, at ambient temperature, very
Readily volatilized one-tenth gas, can set off an explosion when the concentration is too high.Oxirane does not damage the article of sterilizing and wears
Power is very strong thoroughly, is one of current topmost low temperature sterilization method.Advantage is: l can kill all microorganisms,
Including bacterial spore；2 sterilizing articles can be wrapped, overall package, in aseptic condition before can keeping using；
3 do not corrode plastics, metal and rubber, and article generation flavescence will not be made to become fragile；4 can penetrate form irregularity
Product sterilizing；5 can be used for those can not soak by disinfectant, xeothermic, pressure, steam and other chemical gas
The sterilizing of the article of sterilizing.Shortcoming is: 1 oxirane disinfection needs to carry out in hermetic container；2 by environment
Temperature and humidity impact is bigger；3 oxirane are inflammable, explosive, are difficult to transport and preserve.
Summary of the invention
In order to overcome oxirane inflammable, explosive, being difficult to transport and preserve, conventional sterilization must be close
Carry out in the ethylene oxide sterilizer closed, affected bigger technological deficiency by ambient temperature and humidity.This
Bright oxirane is dissolved in isopropanol with relatively low concentration, is aided with the compounds such as parachlorometaxylenol and makes
Obtaining this disinfectant solution cleaning piece surface under the conditions of ethylene oxide content is low-down just has extraordinary sterilizing to imitate
Really.
The present invention seeks to be realized by techniques below scheme:
A kind of oxirane disinfection liquid, including solution A and B solution, solution A is: effective ingredient is peroxide
Acetic acid, citric acid, the mixed aqueous solution of oxalic acid, wherein solution A containing peracetic acid 10000～15000mg/L,
Citric acid 5000～10000mg/L, oxalic acid 2000～5000mg/L, B solution is: effective ingredient is between to chlorine
Xylenols, the mixing aqueous isopropanol of oxirane, wherein B solution is containing to chloroxylenol
15000～20000mg/L, oxirane 400～800mg/L, solution A and B solution in actual application
Consumption volume ratio be 2～4:1.
Further above-mentioned oxirane disinfection liquid, preferably solution A contain peracetic acid 12000～14000mg/L,
Citric acid 6000～8000mg/L, oxalic acid 3000～4000mg/L.
Further above-mentioned oxirane disinfection liquid, preferably B solution are containing to chloroxylenol 16000～18000
Mg/L, oxirane 500～700mg/L.
The oxirane disinfection liquid that the present invention provides, in addition to using the oxirane with obvious sterilizing effect,
Also added other compound, to increase the bactericidal effect of this disinfectant solution, specifically:
Parachlorometaxylenol is soluble in organic solvent and the strong alkali aqueous solutions such as alcohol, ether, polyglycols.Chemical
Matter is stable, will not inactivate under usual storage requirement.It is the antimildew and antibacterial agent of a kind of wide spectrum, to most grams
Positive, negative bacterium, fungus, mycete kills effect.
Peracetic acid has certain bactericidal ability, and concentration is in 122 mg/litre, as long as half a minute just can be complete
Entirely kill staphylococcus, Salmonella enteritidis, shigella sonnei, secondary dissolved oxygen vibrio；For cause of disease coliform,
Half a minute is the most only needed just can all to kill.Chinese Academy of Medical Sciences's epidemic research research it is also shown that
Peracetic acid to first kind streptococcus, blocked coccus, Diplococcus pneumoniae, Staphylococcus albus and influenza virus etc.
Respiratory tract is cured the disease microorganism, smokes in indoor latter 30 minutes, in addition to first streptococcus has individual colonies, and remaining quilt entirely
Kill, test it is also shown that peracetic acid also kill diphtheria corynebacterium and epidemic cerebrospinal meningitis, measles,
The effect of cheek line inflammation virus.For the various bacteria such as bacillus pyocyaneus, Trichophyton, fungus, vinegar also can have very
Strong kills ability.On tcm clinical practice and in folk remedy, all it is widely used for vinegar preventing and treating surgery, skin
The multiple disease of skin section, and achieve preferable effect.
Oxalic acid, citric acid, be widely present in nature for simplest binary acid, oxalic acid and citric acid,
Using and environment and the person will not be caused any harm by production process, production will not corrode instrument and equipment,
Also there is the generation reducing pollutant, it is achieved cleaning produces, the advantage of protection environment.
The compound method of oxirane disinfection liquid:
Above-mentioned disinfectant solution component is got the raw materials ready by content ratio, its ethylene oxide, isopropanol be cooled to 4～8 DEG C standby
With.The preparation of solution A: take peracetic acid, citric acid, oxalic acid soluble in water, mix homogeneously, bottle close
Envelope saves backup；The preparation of B solution: take and be dissolved in chloroxylenol, oxirane in isopropanol, mixing is all
Even, bottling sealing saves backup.
The using method of oxirane disinfection liquid:
Solution A and B solution are independent packaging, are 2～4:1 by volume by solution A and B solution during use
Measuring respectively, stirring is allowed to mix homogeneously.After using this disinfectant solution wiping table top, by institute's wiping table top place
Airtight space 10～whole table top and space, place can be carried out disinfection after 90 minutes.
The using method of further above-mentioned oxirane disinfection liquid, preferably by empty to institute's wiping table top and table top place
Between airtight 30～60 minutes.
The invention have the benefit that and the invention provides a kind of medical oxirane disinfection liquid, this disinfectant solution
The oxirane of low concentration is dissolved in isopropanol, is aided with parachlorometaxylenol and solution A makes ring
Just there is extraordinary sterilization effect oxidative ethane cleaning piece surface at very low concentrations；This disinfectant solution is not required to
Closed environment to be carried out, to be also not susceptible to the impact of ambient temperature and humidity；Solve epoxy second simultaneously
Alkane is inflammable, explosive, is difficult to transport and preserves, the problem poisonous to people.This disinfectant solution oxirane is with relatively low
Concentration is dissolved in isopropanol, safer for relative simple ring oxidative ethane, it is easier to preserve.Use this
After bright disinfectant solution wiping table top, peracetic acid, oxalic acid, oxirane evaporate into whole close from mesa surfaces
Close space, whole space can be carried out disinfection.Use and environment and the person will not be caused wound by production process
Evil, low price.
Detailed description of the invention
According to following embodiment, the present invention be may be better understood.But, those skilled in the art is easy
Understanding, concrete material proportion, process conditions and result thereof described by embodiment are merely to illustrate the present invention
And should be also without limitation on the present invention described in detail in claims.
Embodiment 1
Oxirane disinfection liquid of the present invention is made up of the effective ingredient of following ratio
Solution A (solvent is water)
Peracetic acid 10000mg/L
Citric acid 8000mg/L
Oxalic acid 3000mg/L
B solution (solvent is isopropanol)
To chloroxylenol 20000mg/L
Oxirane 500mg/L
The preparation of oxirane disinfection liquid:
1. getting the raw materials ready by content ratio according to above-mentioned disinfectant solution component, its ethylene oxide, isopropanol are cooled to
4-8 DEG C standby；
2. the preparation of solution A: take peracetic acid, citric acid, oxalic acid soluble in water, mix homogeneously, bottling
Standby；
3. the preparation of B solution: take and chloroxylenol, oxirane are dissolved in isopropanol, mix homogeneously, dress
Bottle is standby；
The using method of oxirane disinfection liquid: solution A and B solution are independent packaging, by A during use
Solution and B solution use according to after volume ratio 3:1 mix homogeneously.
Embodiment 2
Oxirane disinfection liquid of the present invention is made up of the effective ingredient of following ratio
Solution A (solvent is water)
Peracetic acid 12000mg/L
Citric acid 6000mg/L
Oxalic acid 2000mg/L
B solution (solvent is isopropanol)
To chloroxylenol 15000mg/L
Oxirane 400mg/L
The preparation of oxirane disinfection liquid:
1. getting the raw materials ready by content ratio according to above-mentioned disinfectant solution component, its ethylene oxide, isopropanol are cooled to
4-8 DEG C standby；
2. the preparation of solution A: take peracetic acid, citric acid, oxalic acid soluble in water, mix homogeneously, bottle standby
With；
3. the preparation of B solution: take and chloroxylenol, oxirane are dissolved in isopropanol, mix homogeneously, dress
Bottle is standby；
The using method of oxirane disinfection: solution A and B solution are independent packaging, during use, A is molten
Liquid and B solution use according to after volume ratio 2:1 mix homogeneously.
Embodiment 3
Oxirane disinfection liquid of the present invention is made up of the effective ingredient of following ratio
Solution A (solvent is water)
Peracetic acid 15000mg/L
Citric acid 5000mg/L
Oxalic acid 5000mg/L
B solution (solvent is isopropanol)
To chloroxylenol 18000mg/L
Oxirane 500mg/L
The preparation of oxirane disinfection liquid:
1. getting the raw materials ready by content ratio according to above-mentioned disinfectant solution component, its ethylene oxide, isopropanol are cooled to
4-8 DEG C standby；
2. the preparation of solution A: take peracetic acid, citric acid, oxalic acid soluble in water, mix homogeneously, bottling
Standby；
3. the preparation of B solution: take and chloroxylenol, oxirane are dissolved in isopropanol, mix homogeneously, dress
Bottle is standby；
The using method of oxirane disinfection liquid: solution A and B solution are independent packaging, by A during use
Solution and B solution use according to after volume ratio 4:1 mix homogeneously.
Embodiment 4
Oxirane disinfection liquid of the present invention is made up of the effective ingredient of following ratio
Solution A (solvent is water)
Peracetic acid 14000mg/L
Citric acid 9000mg/L
Oxalic acid 3000mg/L
B solution (solvent is isopropanol)
To chloroxylenol 16000mg/L
Oxirane 500mg/L
The preparation of oxirane disinfection liquid:
1. getting the raw materials ready by content ratio according to above-mentioned disinfectant solution component, its ethylene oxide, isopropanol are cooled to
4-8 DEG C standby；
2. the preparation of solution A: take peracetic acid, citric acid, oxalic acid soluble in water, mix homogeneously, bottling
Standby；
3. the preparation of B solution: take and chloroxylenol, oxirane are dissolved in isopropanol, mix homogeneously, dress
Bottle is standby；
The using method of oxirane disinfection liquid: solution A and B solution are independent packaging, by A during use
Solution and B solution use according to after volume ratio 3:1 mix homogeneously.
Embodiment 5
Being prepared by embodiment 1,2,3,4 respectively by disinfectant solution of the present invention, after mix homogeneously, wiping is ultra-clean
The table top of platform, wiping was complete, by airtight for super-clean bench 30 minutes.
Embodiment 6
Disinfectant solution of the present invention is prepared by embodiment 1, the table top of wiping super-clean bench after mix homogeneously, wipe
Wipe complete, super-clean bench is distinguished airtight 10,30,60,90 minutes.
Experimental technique:
The preparation of MH (Mu11er Hinton) culture medium: weigh beef extract 5g and be dissolved in water 800mL, adds
Peptone 10g dissolves, and adds casein 34g and dissolves, and adds NaCl 5g and dissolves, is adjusted to pH7.6～7.8, dilute
Release to 1000mL.Add agar powder 18g, autoclaving 15min, when being cooled to 40 DEG C～50 DEG C, a kind of rhyme scheme in Chinese operas serving as the prelude to a complete score for voices,
Solidification, the 4 DEG C of refrigerators placing no bacteria pollution are standby.
Carry out disinfection with the common sterilization method of super-clean bench and compare: 1. use alcohol wipe table top, 2. open ultraviolet
Light irradiation 30 minutes.Sampling in 4h after carrying out disinfection super-clean bench, super-clean bench table top sets 3 sample points, ultra-clean
3 points are taken on the inner opposite angle line of platform space.
Total number of bacterial colonies inspection result:
The sterilization effect of disinfectant solution and the relation of time in embodiment 6:
Result shows that the oxirane disinfection liquid that the present invention provides can be prevented effectively from oxirane can only be airtight
The defect carried out disinfection in space, is also not susceptible to the impact of ambient temperature and humidity, it is easy to storage and transport.
And the present invention is possible not only to carry out disinfection table top and can also carry out disinfection whole space.The present invention provides
Disinfectant solution also there is spectrum bactericidal properties, the advantages such as sterilizing ability is strong, and speed of action is fast.Therefore, the present invention
The disinfectant solution provided is preferable Medical antiseptic solution.
Embodiment of above only for technology design and the feature of the present invention are described, its object is to allow and is familiar with this
The people of technology understands present invention and is carried out, and can not limit the scope of the invention with this, all
The equivalence change done according to spirit of the invention or modification, all should contain within the scope of the present invention.
Claims (6)
1. an oxirane disinfection liquid, it is characterised in that include solution A and B solution, solution A is:
Effective ingredient is the mixed aqueous solution of peracetic acid, citric acid, oxalic acid, and wherein solution A contains peracetic acid
10000～15000mg/L, citric acid 5000～10000mg/L, oxalic acid 2000～5000mg/L；B solution is:
Effective ingredient is the mixing aqueous isopropanol of parachlorometaxylenol, oxirane, and wherein B solution is containing to chlorine
Xylenols 15000～20000mg/L, oxirane 400～800mg/L, solution A in actual application
It is 2～4:1 with the consumption volume ratio of B solution.
Oxirane disinfection liquid the most according to claim 1, it is characterised in that solution A second Han peroxide
Acid 12000～14000mg/L, citric acid 6000～8000mg/L, oxalic acid 3000～4000mg/L.
Oxirane disinfection liquid the most according to claim 1, it is characterised in that B solution is containing to chlorine two
Cresols 16000～18000mg/L, oxirane 500～700mg/L.
4. the compound method of oxirane disinfection liquid:
1. get the raw materials ready by content ratio according to the component described in any one of claim 1-3, its ethylene oxide, isopropyl
Alcohol be cooled to 4-8 DEG C standby；
2. solution A preparation: take peracetic acid, citric acid, oxalic acid soluble in water, mix homogeneously, bottle close
Envelope saves backup；
3. B solution preparation: take and chloroxylenol, oxirane are dissolved in isopropanol, mix homogeneously, bottling
Sealing saves backup.
5. the using method of oxirane disinfection liquid, solution A and B solution are independent packaging, will during use
Solution A and B solution are according to the volume ratio mix homogeneously of the oxirane disinfection liquid described in claim 1；Its
It is characterised by:
1. the volume ratio as described in claim 1 measures solution A and B solution respectively, and stirring is allowed to mixing all
Even；
2. this disinfectant solution wiping table top is used；
3. by institute's wiping table top and table top place airtight space 10～90 minutes.
6. according to the using method of the oxirane disinfection liquid described in claim 5, it is characterised in that will be wiped
Wipe table top and table top place airtight space 30～60 minutes.
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| Application Number | Priority Date | Filing Date | Title |
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| CN201510182292.XA CN104798782B (en) | 2015-04-16 | 2015-04-16 | Oxirane disinfection liquid and preparation and using method |
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|---|---|---|---|
| CN201510182292.XA CN104798782B (en) | 2015-04-16 | 2015-04-16 | Oxirane disinfection liquid and preparation and using method |
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| CN104798782A CN104798782A (en) | 2015-07-29 |
| CN104798782B true CN104798782B (en) | 2016-09-14 |
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Citations (6)
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| CN1694948A (en) * | 2002-08-28 | 2005-11-09 | 李镇植 | A composition for disinfecting or washing medical instruments and a process for the preparation thereof |
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| US20070258915A1 (en) * | 2006-05-02 | 2007-11-08 | Andrew Kielbania | Anti-Microbial Composition and Method for Making and Using Same |
| US20100160449A1 (en) * | 2008-12-18 | 2010-06-24 | Fmc Corporation | Peracetic Acid Oil-Field Biocide and Method |
| CN102696590A (en) * | 2012-06-25 | 2012-10-03 | 广州市君禾实业有限公司 | Peracetic acid in single-ingredient disinfection solution and preparation method thereof |
-
2015
- 2015-04-16 CN CN201510182292.XA patent/CN104798782B/en not_active Expired - Fee Related
Patent Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1694948A (en) * | 2002-08-28 | 2005-11-09 | 李镇植 | A composition for disinfecting or washing medical instruments and a process for the preparation thereof |
| CN1771059A (en) * | 2003-04-18 | 2006-05-10 | 朗福德Ic系统有限公司 | Supplemental ozone treatment methods for difficult cleaning and sterilizing applications |
| CN1954061A (en) * | 2004-05-11 | 2007-04-25 | 斯泰尔瑞斯公司 | Acidic phenolic disinfectant compositions |
| US20070258915A1 (en) * | 2006-05-02 | 2007-11-08 | Andrew Kielbania | Anti-Microbial Composition and Method for Making and Using Same |
| US20100160449A1 (en) * | 2008-12-18 | 2010-06-24 | Fmc Corporation | Peracetic Acid Oil-Field Biocide and Method |
| CN102696590A (en) * | 2012-06-25 | 2012-10-03 | 广州市君禾实业有限公司 | Peracetic acid in single-ingredient disinfection solution and preparation method thereof |
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| Title |
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| 协同消毒;袁松范;《医药工程设计》;19971231;参见第9、30-31页 * |
| 环氧乙烷灭菌技术在消毒供应室灭菌中的效果观察;陈国玲;《临床合理用药》;20140930;第7卷(第9期);参见第170页 * |
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