CN103843764B - A kind of strengthening modified glutaraldehyde disinfectant solution and preparation method thereof - Google Patents
A kind of strengthening modified glutaraldehyde disinfectant solution and preparation method thereof Download PDFInfo
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- CN103843764B CN103843764B CN201410122384.4A CN201410122384A CN103843764B CN 103843764 B CN103843764 B CN 103843764B CN 201410122384 A CN201410122384 A CN 201410122384A CN 103843764 B CN103843764 B CN 103843764B
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Abstract
A kind of strengthening modified glutaraldehyde disinfectant solution and preparation method thereof, relates to disinfectant.The raw material composition of described strengthening modified glutaraldehyde disinfectant solution and content by mass percentage thereof are glutaraldehyde 18%～22%, glucose 5%～10%, polyoxyethylene aliphatic alcohol ether 5%～10%, purified water 58%～72%.Glutaraldehyde, glucose, purified water are added heated and stirred in retort, then polyoxyethylene aliphatic alcohol ether adds continuation stirring in retort, after being cooled to room temperature, i.e. obtains strengthening modified glutaraldehyde disinfectant solution.Product is aqueous solution, good stability, and abnormal smells from the patient is thin；Major part microorganism can be killed；Aerobic and the sprouting of anaerobic spore can be suppressed under very low concentrations；Use pH wide ranges, can higher temperature resistant；Bacterial propagule can be killed in 2min；Sterilizing in Organic substance and crack can be penetrated；Ambient temperatare puts 540d, and sterilizing usefulness does not subtracts；Noresidue, zest is little, and corrosivity is low, safety and low toxicity.
Description
Technical field
The present invention relates to a kind of disinfectant, especially relate to a kind of strengthening modified glutaraldehyde disinfectant solution and preparation method thereof.
Background technology
Glutaraldehyde not only to the well killing action such as bacterial propagule, spore, tubercule bacillus, fungus and virus, also has relatively
Strong anthelminthic effect, is the best substitute of formaldehyde (formalin).Glutaral disinfectant solution stability in the market is relatively
Difference, irritant abnormal smells from the patient, eyes, skin and mucosa there are is strong impulse effect, suction can cause larynx, bronchus
Inflammation, chemical pneumonitis, pulmonary edema etc., also can cause allergic reaction.
Chinese patent CN94102774.0 provides a kind of stable glutaraldehyde water solution, and formula is: glutaraldehyde water solution, non-
Ionic detergent, sodium acetate and be enough to the pH adjusting agent of the q.s making solution ph be 6.9～8.5.
Summary of the invention
It is an object of the invention to provide and have sterilization effect preferably, action time is short, and action effect is stable, zest gas
Taste is little, less to eyes, skin and mucous membrane irritation effect, has again a kind of strengthening modified glutaraldehyde sterilization of stronger anthelminthic effect
Liquid and preparation method thereof.
The raw material composition of described strengthening modified glutaraldehyde disinfectant solution and content by mass percentage thereof be glutaraldehyde 18%～22%,
Glucose 5%～10%, polyoxyethylene aliphatic alcohol ether 5%～10%, purified water 58%～72%.
Specifically comprising the following steps that of the preparation method of described strengthening modified glutaraldehyde disinfectant solution
Glutaraldehyde, glucose, purified water are added heated and stirred in retort, then polyoxyethylene aliphatic alcohol ether is added retort
Middle continuation stirs, and after being cooled to room temperature, must strengthen modified glutaraldehyde disinfectant solution.
The condition of described heated and stirred can be to stir 180～300min with 50r/min speed at 40～60 DEG C；Described continuation stirs
The time mixed can be 45～90min.
The present invention prepares the strengthening modified glutaraldehyde disinfectant solution of gained and can transport with transfer cask, and resampling detects, and detection is passed through
After, then transfer cask is delivered to packing shop pack according to the requirement of client.Described transfer cask is preferably 100L transfer cask；
Described resampling detects, and after preferably transfer cask places at least 12h, just sampling detects.
Comparing with like product, the present invention has an advantage highlighted below:
1) product is aqueous solution, good stability, and abnormal smells from the patient is thin.
2) more efficient: broad-spectrum sterilization, most microorganism can be killed；Aerobic and anaerobic can be suppressed under very low concentrations
The sprouting of spore；Use pH wide ranges, can higher temperature resistant.
3) more rapid: generally, bacterial propagule can be killed in 2min；There is extremely strong penetration power, can there is penetrated with
Sterilizing in machine thing and crack.
4) more longlasting: ambient temperatare puts 540d, sterilizing usefulness does not subtracts.
5) safer: noresidue, zest is little, and corrosivity is low, safety and low toxicity.
Detailed description of the invention
The present invention is further illustrated for following example.
Embodiment 1
The raw material composition of described strengthening modified glutaraldehyde disinfectant solution and content by mass percentage thereof are glutaraldehyde 18%, glucose
6%, polyoxyethylene aliphatic alcohol ether 6%, purified water 70%.
The preparation method of strengthening modified glutaraldehyde disinfectant solution of the present invention comprises the following steps:
1) glutaraldehyde, purified water, glucose are added retort, be heated to 40～60 DEG C, at this temperature with 50r/min speed
Degree stirring, mixing time 180～300min.
2) polyoxyethylene aliphatic alcohol ether is added retort, continue stirring 45～90min.
3) it is cooled to room temperature, obtains product.
4) step 3) products obtained therefrom is loaded 100L transfer cask, sample after placing 12h and detect, then transfer cask is delivered to
Packing shop is packed according to the requirement of client.
Use the scene (wall to H9N2 bird flu virus (AIV) of the strengthening modified glutaraldehyde disinfectant solution prepared by embodiment 1
Wall, utensil) Disinfection Effect: found by on-site disinfection test, 1: 200 strengthening modified glutaraldehyde disinfectant solution effect 30min or
AIV H9N2 can be killed by 1: 500 mass action 60min completely.In view of disinfectant when reality is applied can by many because of
The impact of element, therefore need to adjust disinfectant concentration and action time in time, to reach when reality is applied according to practical situation
Desired sanitisation effect.Strengthening modified glutaraldehyde disinfectant solution sees table 1 to the result for spot disinfection of H9N2 bird flu virus (AIV).
Table 1
Product physicochemical property:
Character: this product is colourless to weak yellow liquid；
Relative density: 1.030～1.040；
PH value: 2.9.
Embodiment 2
The raw material composition of described strengthening modified glutaraldehyde disinfectant solution and content by mass percentage thereof are glutaraldehyde 20%, glucose
7%, polyoxyethylene aliphatic alcohol ether 7%, purified water 66%.
The preparation method of described strengthening modified glutaraldehyde disinfectant solution comprises the following steps:
1) glutaraldehyde, purified water, glucose are added retort, be heated to 40～60 DEG C, at this temperature with 50r/min speed
Degree stirring, mixing time 180～300min.
2) polyoxyethylene aliphatic alcohol ether is added retort, continue stirring 45～90min.
3) it is cooled to room temperature, obtains product.
4) step 3) products obtained therefrom being loaded 100L transfer cask, after placing 12h, just sampling detects, then is sent by transfer cask
Pack to packing shop according to the requirement of client.
The use strengthening modified glutaraldehyde disinfectant solution prepared by embodiment 2 inactivating efficacy to Pseudorabies virus (PRV):
More than containing 3000mg/L strengthening modified glutaraldehyde disinfectant solution and Pseudorabies virus suspension immixture 30min, respectively test
Group is all not detected by survival virus.Test shows, 3000mg/L strengthening modified glutaraldehyde disinfectant solution is to Pseudorabies virus in suspension
Effect 30min, can reach complete inactivation.Strengthening modified glutaraldehyde disinfectant solution sees table 2 to the inactivating efficacy of Pseudorabies virus.
Table 2
| Action time (min) | Inactivation of virus titre logarithm value |
| 30 | ≥6.50 |
| 60 | ≥6.50 |
| 120 | ≥6.50 |
| 240 | ≥6.50 |
Note: the logarithm value of positive control virus titre (TCID50/0.1ml) is 6.50
Embodiment 3
The raw material composition of described strengthening modified glutaraldehyde disinfectant solution and content by mass percentage thereof are glutaraldehyde 22%, glucose
8%, polyoxyethylene aliphatic alcohol ether 8%, purified water 62%.
The preparation method of described strengthening modified glutaraldehyde disinfectant solution comprises the following steps:
1) glutaraldehyde, purified water, glucose are added retort, be heated to 40～60 DEG C, at this temperature with 50r/min speed
Degree stirring, mixing time 180～300min.
2) polyoxyethylene aliphatic alcohol ether is added retort, continue stirring 45～90min.
3) it is cooled to room temperature, obtains product.
4) step 3) products obtained therefrom being loaded 100L transfer cask, after placing 12h, just sampling detects, then is sent by transfer cask
Pack to packing shop according to the requirement of client.
Use the strengthening modified glutaraldehyde disinfectant solution prepared by embodiment 3 that bacillus subtilis black variety gemma on carrier is killed effect
Really:
Test shows, strengthening modified glutaraldehyde disinfectant solution (experimental group) with concentration as 20g/L is to bacillus subtilis black on carrier
Mutation spore effect 60min, averagely killing logarithm value is 5.09.Under same concentrations, common glutaral disinfectant solution (matched group) is right
Bacillus subtilis black variety gemma effect 60min on carrier, averagely killing logarithm value is 3.98.
Table 3
Strengthening modified glutaraldehyde disinfectant solution sees table 3 to the killing effect of bacillus subtilis black variety gemma on carrier.
Claims (3)
1. the preparation method strengthening modified glutaraldehyde disinfectant solution, it is characterised in that its raw material composition and content by mass percentage thereof be glutaraldehyde 18%～22%, glucose 5%～10%, polyoxyethylene aliphatic alcohol ether 5%～
10%, purified water 58%～72%, glutaraldehyde, glucose, purified water are added heated and stirred in retort by specifically comprising the following steps that of its preparation method, again polyoxyethylene aliphatic alcohol ether is added and retort continues stirring, after being cooled to room temperature, modified glutaraldehyde disinfectant solution must be strengthened.
2. a kind of preparation method strengthening modified glutaraldehyde disinfectant solution as described in claim 1, it is characterised in that the condition of described heated and stirred is to stir with 50r/min speed at 40～60 DEG C
180～300min.
A kind of preparation method strengthening modified glutaraldehyde disinfectant solution the most as claimed in claim 1, it is characterised in that the time of described continuation stirring is 45～90min.
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| CN103843764B true CN103843764B (en) | 2016-08-17 |
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| CN112931502A (en) * | 2019-12-11 | 2021-06-11 | 山东菏泽三仪生物工程有限公司 | Compound glutaraldehyde reinforced disinfectant and preparation method thereof |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1100135A (en) * | 1993-01-29 | 1995-03-15 | 托尼·马丁销售和批发公司 | A glutaraldehyde composition |
| CN103118538A (en) * | 2010-06-25 | 2013-05-22 | Gx实验室控股有限公司 | Disinfecting and sterilising solutions |
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2014
- 2014-03-28 CN CN201410122384.4A patent/CN103843764B/en active Active
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1100135A (en) * | 1993-01-29 | 1995-03-15 | 托尼·马丁销售和批发公司 | A glutaraldehyde composition |
| CN103118538A (en) * | 2010-06-25 | 2013-05-22 | Gx实验室控股有限公司 | Disinfecting and sterilising solutions |
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