CN104784814A - Tumor nanosecond impulse electro-therapeutic apparatus - Google Patents
Tumor nanosecond impulse electro-therapeutic apparatus Download PDFInfo
- Publication number
- CN104784814A CN104784814A CN201510217295.2A CN201510217295A CN104784814A CN 104784814 A CN104784814 A CN 104784814A CN 201510217295 A CN201510217295 A CN 201510217295A CN 104784814 A CN104784814 A CN 104784814A
- Authority
- CN
- China
- Prior art keywords
- resistance
- capacitor
- feet
- foot
- circuit
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Abstract
The invention belongs to a tumor nanosecond impulse electro-therapeutic apparatus comprising a current transformer (5), a single-chip microcomputer (6) and a gas spark switch (3). The tumor nanosecond impulse electro-therapeutic apparatus is characterized in that the single-chip microcomputer (6) is connected with a high-voltage direct-current power circuit (1) which is connected with an LC resonance circuit (2), and the LC resonance circuit (2) is connected with the gas spark switch. Pain to patients due to surgery and chemoradiotherapy in tumor treatment is solved, side effects caused by scars and and inflammation in the treatment process are avoided, and harm to normal cells is reduced to the greatest extent.
Description
Technical field
The invention belongs to armarium, particularly a kind of tumor nanosecond pulse electric therapeutic instrument.
Background technology
The mode of conventional treatment tumor has operation, radiation and chemotherapy at present.If tumor is confined to original site or certain area, topical therapeutic often can obtain good effect, but the feature of tumor cell is diffusion and transfer, once shift, only dependence topical therapeutic cannot.So usually can Combined with Radiotherapy chemotherapy.But chemicotherapy belongs to whole body therapeutic, also normal cell can be killed while killing cancerous cell, also can produce the side effect such as gastrointestinal function wadding unrest, bone marrow depression, alopecia, reduce the life quality of patient.In contrast to this, with the mode of electrotherapy, cell death inducing, meet human homergy's process, maximum Chengdu reduce the side effect produced in Quality Process, for mankind's oncotherapy history opens new epoch simultaneously!
Nanosecond pulse electric field, by utilizing endocellular electricity Treatment Effects, reaches cell death inducing, object that Tumor suppression tissue growth, induced cell cycle change, finally makes tumor cell automatically melt the object reaching treatment.
Cell in human body is doomed to dead, and some death is physiological, and some is then pathologic.Dead mode has two kinds: necrocytosis and apoptosis.Necrosis is the death process that cell is subject to that strong physics and chemistry or biological factor effect cause the unordered change of cell.Show as cell to swell, after birth breaks, and cellular content is excessive, and nuclear change is comparatively slow, and DNA degradation is insufficient, causes the inflammatory reaction that local is serious.Apoptosis refers to for maintaining homeostasis, the orderly death autonomous by the cell of Gene Handling.It is the basic biological phenomena of one of cell, removes in unwanted or abnormal cell play a part necessity multicellular organism.It plays an important role in the growth of stable and multiple system of the evolution of organism, environment.As can be seen here, apoptosis is the physiopathological sexual stimulus signal of cell to environment, the death process that the response that the change of environmental condition or retentivity damage produce changes in order.Be multistage in morphologic change, apoptosis often relates to individual cells, even if sub-fraction cell is also asynchronous generation.What first occur is that cell volume reduces, and connects and disappears, and with the cell detachment of surrounding, is then that cytoplasmic densitometric increases, mitochondrial membrane potential disappears, permeability changes, and release cells pigment C is to endochylema, caryoplasm concentrates, and nuclear membrane kernel is broken, and DNA degradation becomes about 180bp-200bp fragment; After birth has little blister to be formed, film surface is translated into outside Phosphatidylserine inside film, after birth structure is still complete, can be finally several apoptotic body by apoptotic cell remains segmentation parcel, excessive without content, therefore do not cause the inflammatory reaction of surrounding, apoptotic body can or non-full-time phagocyte full-time by surrounding be engulfed rapidly.
It is by apoptosis enzyme Caspase in extracellular signal active cell that apoptotic approach mainly contains two: one, and another is by mitochondrion release apoptosis enzyme activition factor activator Caspase.And the effect of nanosecond pulsed electric field mainly stimulates to extracellular signal, start with cell death inducing program, the stimulating electrical signal of short time can not cause necrocytosis again simultaneously, avoid causing other untoward reaction of cell, and effectively reach Tumor suppression tissue growth, the object that induced cell cycle changes.
Summary of the invention
The object of the invention is to solve the problems of the technologies described above, there is provided a kind of nanosecond utilizing potential pulse to produce in time to the electric field intensity of length, penetrate tumor cell place film, effect and inner organelle, cell death inducing, thus taken out of external tumor nanosecond pulse electric therapeutic instrument by phagocyte.
The technical scheme that technical solution problem of the present invention adopts is: a kind of tumor nanosecond pulse electric therapeutic instrument, comprise current transformer, single-chip microcomputer and gas spark switch, it is characterized in that single-chip microcomputer and high-voltage DC power supply circuit communication, high voltage direct current source circuit and LC resonance circuit UNICOM, LC resonance circuit and gas spark switch UNICOM; High voltage direct current source circuit comprises NC22OV power supply and is connected with 1,2 feet of KBU8104 rectifier bridge, 3 feet of KBU8104 rectifier bridge connect 1 foot of capacitor C6 one end and insulating gate type field effect tube Q1, Q3, and 4 feet connect secondary T1-3, the T1-5 of transformator T1, resistance R25, R29,2 feet of insulating gate type field effect tube Q2, Q4 and the other end of capacitor C6 and ground; The two ends of primary coil T1-1 two termination Zener diode TVS of transformator T1 and one end of capacitor C17; Difference connecting resistance R26, R27 one end, two ends of transformator T1 secondary coil T1-4 and 2 feet of transformator T2,3 feet of another termination insulating gate type field effect tube Q3 of resistance R26, R27; Transformer secondary coil T1-5 other end connecting resistance R28 one end, 3 feet of another termination insulating gate type field effect tube of resistance R28, R29 Q4; Connecting resistance R22, resistance R23 one end respectively, secondary coil T1-2 two ends of transformator T2; 1 foot of insulating gate type field effect tube Q2 connects the other end of 2 feet of insulating gate type field effect tube Q1,1 foot of transformator T2 and resistance R23; 3 feet of transformator T2 connect one end of the other end of the resistance R17 in A amplifying circuit U1D, capacitor C11, C12, resistance R30 and diode D5; The capacitor C11 other end connecting resistance R30 other end and ground; Another termination of capacitor C12 multiple diode D3, D4 ... .Dn, one end of Dn+1; 4 feet of transformator T2 connect one end of capacitor C8; Another terminating diode D5, D3 of capacitor C8 and one end of capacitor C9; The other end of another termination multiple diode D4, Dn of capacitor C9 and one end of capacitor C10; Another terminating diode Dn+1 of capacitor C10, resistance R31 one end, resistance R31 connects multiple resistance R32 ~ Rn; Other end connecting resistance R33, the capacitor C7 of resistance Rn and center resistance R21 one end of B amplifying circuit U2D; The other end ground connection of voltage sampling resistor R33 and capacitor C7; 2 feet of negative feedback B connect 7 feet of voltage PID actuator U1B1-2, and 3 feet connect 3 feet of variable resistance UR2; 1 foot of variable resistance UR2 connects+10V power supply, 2 foot ground connection; Secondary coil T1-2 mono-terminating resistor R22 one end of transformator T1, other end connecting resistance R23 one end; 2 feet of insulating gate type field effect tube Q1 connect 1 foot of insulating gate type field effect tube Q2 and 1 foot of transformator T2; The other end of 3 foot connecting resistance R22, R23 of insulating gate type field effect tube Q1; The other end of 3 foot connecting resistance K24, R25 of insulating gate type field effect tube Q2; One end of 3 foot connecting resistance R26, R27 of insulating gate type field effect tube Q3; The two ends of the secondary line level circle T1-4 of another termination transformator T1 of resistance R26, R27; One end of 3 foot connecting resistance R28, R29 of insulating gate type field effect tube Q4; The two ends of the secondary coil T1-5 of another termination transformator T1 of resistance R28, R29; 1 foot of negative feedback A connects the resistance R17 one end in A amplifying circuit U1D; 2 feet connect 1 foot of current PI D regulating circuit U1A, and 3 feet connect 3 feet of variable resistance VR1; 1 foot of variable resistance VR1 connects+10V power supply, 2 foot ground connection; The capacitor C17 other end is connected with SG3525 chip circuit with one end of transient state killer tube TVS; SG3525 chip circuit is connected with overvoltage crowbar U2E; Electric current P1D regulating circuit U1A is connected with automatic ruling circuit U 1C; Automatic ruling circuit U 1C is connected with voltage P1D regulating circuit U1B and follower circuit U1E.
Described A amplifying circuit U1D, is made up of TL064 operational amplifier U1D and resistance R14, R16, R17, R18; One end of the 12 foot connecting resistance R17 of operational amplifier U1D, one end of 13 foot connecting resistance R18 and R16, the other end of 14 foot connecting resistance R14 one end and R16; The other end ground connection of resistance R18.
Described B amplifying circuit U2D, is made up of TL064 operational amplifier U2D and resistance R15, R19, R20; The other end of the 12 foot connecting resistance R21 of TL064 operational amplifier U2D, one end of 13 foot connecting resistance R19, R20,4 feet meet power supply+UCC, and 11 feet meet power supply-VCC, 14 foot connecting resistance R15 one end and the resistance R20 other end; Resistance R19 other end ground connection.
Described voltage PID regulating circuit U1B; be made up of TL064 operational amplifier U1B, capacitor C3, C4 and resistance R5 ~ R8; 7 feet of TL064 operational amplifier U1B connect the negative pole of the diode D2 in capacitor C4 one end and automatic ruling circuit; one end of 6 foot connecting resistance R5, R7 and capacitor C3, one end of 5 foot connecting resistance R8; The interface of another termination SIM32F103 single-chip microcomputer of resistance R8; The other end of the other end connecting resistance R6 of capacitor C3; Resistance 5 other end is connected with the capacitor C4 other end.
Described current PI D adjuster circuit U1A, be made up of TL064 operational amplifier U1A, capacitor C1, C2 and resistance R1 ~ R4,1 foot of TL064 operational amplifier U1A connects the negative pole of the diode D1 in capacitor C1 one end and automatic ruling circuit, 11 feet meet power supply+VCC, 4 feet meet power supply-VCC, one end of 3 foot connecting resistance R1, R4 and capacitor C3,2 foot connecting resistance R2 one end; The interface of another termination SIM32F103 single-chip microcomputer of resistance R2; The other end of capacitor C2 is connected with the resistance R3 other end.
Described automatic ruling circuit U 1C, is made up of TL064 operational amplifier U1C, diode D1, D2 and resistance R9, R10, R11; The one end of resistance R12 in 8 foot connecting resistance R10 one end of TL064 operational amplifier U1C and SG3525 chip periphery circuit, the positive pole of the 9 foot connecting resistance R10 other ends, resistance R11 one end and two pole D1, D2,10 foot connecting resistance R9 one end; Resistance R9 other end ground connection; Another termination power of resistance R11-VCC.
Described SG3525 chip periphery circuit, is made up of SG3525 chip U2, resistance R12, R13 and capacitor C5; 13,15 feet of SG3525 chip U2 meet power supply+VCC, the 9 foot connecting resistance R12 other ends, and 5,7 feet connect one end of capacitor C5,6 foot connecting resistance R13 one end, 1,2,12 foot ground connection; Resistance R13 other end ground connection; Capacitor C5 other end ground connection.
Described follower circuit U1E, is made up of TL064 operational amplifier U1E, capacitor C17, C18 and resistance R36, R37; The 1 foot connecting resistance R37 of TL064 operational amplifier U1E and one end of capacitor C18,2 feet connect the capacitor C18 other end and resistance R36 one end, and 3 feet connect 8 feet of TL064 operational amplifier U1C in automatic ruling circuit; The other end of resistance R36, R37 connects with capacitor C17 one end and connects with 8 feet of resistance R12, TL064 operational amplifier U1C in SG3525 chip periphery circuit; Capacitor C17 other end ground connection.
Described overvoltage crowbar U2E, is made up of TL064 operational amplifier U2E, diode DN+2, capacitor C19, C20, C21, resistance R37 ~ R41 and variable resistance VR3; 5 foot connecting resistance R41, R39, R40 of TL064 operational amplifier U2E and one end of capacitor C19,6 feet connect capacitor C21 and resistance R38 one end, and 7 feet connect the positive pole of capacitor C20 one end, the resistance R41 other end and diode DN+2; Capacitor C20 other end ground connection, 3 feet of another termination variable resistance of resistance R38 VR3; 1 foot of variable resistance VR3 meets power supply VSS, 2 foot connecting resistance R37 one end; The other end of resistance R37 and capacitor C21 connects and ground connection; The resistance R21 other end in another termination B amplifying circuit U2D of resistance R39; The negative pole of diode DN+2 connects 9 feet of the SG3525RWM chip U2 of SG3525 chip periphery circuit.
Described LC resonance circuit, is made up of high-voltage DC power supply E, capacitor C22 ~ C27, inductance L 1 ~ L6 and K switch; Resistance R42, inductance L 1 ~ L6, K switch and resistance R43 is in series with successively, shnt capacitor C22 ~ C27 between the both positive and negative polarity of high-voltage DC power supply E.
The invention has the beneficial effects as follows: the misery that this invention solves operation to oncotherapy, chemicotherapy brings to patient, the side effect such as scar, inflammation can not be caused over the course for the treatment of, at utmost reduce Normocellular injury.
Accompanying drawing explanation
Below in conjunction with accompanying drawing, illustrate with embodiment.
Fig. 1 is the system block diagram of tumor nanosecond pulse electric therapeutic instrument;
Fig. 2 is Fig. 1 mesohigh DC power supply circuit electrical schematic diagram;
Fig. 3 is A amplifying circuit U1D, B amplifying circuit U2D in Fig. 2, voltage PID adjuster circuit U1B, current PI D reconcile circuit U 1A, the electrical schematic diagram of automatic ruling circuit U 1C, SG3525 chip periphery circuit and SIM32F103 single-chip microcomputer;
Fig. 4 is the electrical schematic diagram controlling the circuit overvoltage of follower U1E set-point and protection circuit U2E in Fig. 2;
Fig. 5 is LC resonance circuit network impulse stroke line power principle figure in Fig. 1.
In figure: 1-high voltage direct current source circuit; 1-1-A amplifying circuit U1D; 1-2-voltage PID regulating circuit U1B; The automatic ruling circuit U 1C of 1-3-; 1-4-SG3525 chip periphery circuit; 1-5-current PI D regulating circuit U1A; 1-6-B amplifying circuit U2D; 1-7-follower circuit U1E; 1-8-overvoltage crowbar U2E; 2-LC resonance circuit; 3-gas spark switch; 4-load; 5-current transformer; 6-SIM32F103 single-chip microcomputer; U1A, U1B, U1C, U1D, U3D, U1E, U2E-TL064 operational amplifier; AC22OV-alternating current power supply; DI-KBU8104 rectifier bridge; T1, T2-transformator; Q1 ~ Q4-insulating gate type field effect tube, A, B-negative feedback; K-switch; D1 ~ DN+2 diode; TVS-transient state killer tube; TH-primary coil; T1-2 ~ T1-5-secondary coil; VR1, VR2, VR3-variable resistance; R1 ~ R41-resistance; C1 ~ C21-capacitor; L1 ~ L6-inductance; D1 ~ Dn, Dn+1 ,-diode; U2-SG3525PWM chip.
Detailed description of the invention
Embodiment, with reference to accompanying drawing, a kind of tumor nanosecond pulse electric therapeutic instrument, comprise current transformer 5, single-chip microcomputer 6 and gas spark switch 3. and it is characterized in that single-chip microcomputer 6 and high voltage direct current source circuit 1 UNICOM, high voltage direct current source circuit 1 and LC resonance circuit 2 UNICOM, LC resonance circuit 2 and gas spark switch 3 UNICOM; High voltage direct current source circuit 1 comprises NC22OV power supply and is connected with 1,2 feet of KBU8104 rectifier bridge, 3 feet of KBU8104 rectifier bridge connect 1 foot of capacitor C6 one end and insulating gate type field effect tube Q1, Q3, and 4 feet connect secondary T1-3, the T1-5 of transformator T1, resistance R25, R29,2 feet of insulating gate type field effect tube Q2, Q4 and the other end of capacitor C6 and ground; The two ends of primary coil T1-1 two termination Zener diode TVS of transformator T1 and one end of capacitor C17; Difference connecting resistance R26, R27 one end, two ends of transformator T1 secondary coil T1-4 and 2 feet of transformator T2,3 feet of another termination insulating gate type field effect tube Q3 of resistance R26, R27; Transformer secondary coil T1-5 other end connecting resistance R28 one end, 3 feet of another termination insulating gate type field effect tube of resistance R28, R29 Q4; Connecting resistance R22, resistance R23 one end respectively, secondary coil T1-2 two ends of transformator T2; 1 foot of insulating gate type field effect tube Q2 connects the other end of 2 feet of insulating gate type field effect tube Q1,1 foot of transformator T2 and resistance R23; 3 feet of transformator T2 connect the other end of the resistance R17 in A amplifying circuit U1D1-1, capacitor C11, C12, resistance R30 and diode D5 one end; The capacitor C11 other end connecting resistance R30 other end and ground; Another termination of capacitor C12 multiple diode D3, D4 ... .Dn, one end of Dn+1; 4 feet of transformator T2 connect one end of capacitor C8; Another terminating diode D5, D3 of capacitor C8 and one end of capacitor C9; The other end of another termination multiple diode D4, Dn of capacitor C9 and one end of capacitor C10; Another terminating diode Dn+1 of capacitor C10, resistance R31 one end, resistance R31 connects multiple resistance R32 ~ Rn; Another termination voltage of resistance Rn gets the resistance R21 one end in Chinese catalpa resistance R33, capacitor C7 and B amplifying circuit U2D1-6; The other end ground connection of voltage sampling resistor R33 and capacitor C7; 2 feet of negative feedback B connect 7 feet of voltage PID actuator U1B1-2, and 3 feet connect 3 feet of variable resistance UR2; 1 foot of variable resistance UR2 connects+10V power supply, 2 foot ground connection; Secondary coil T1-2 mono-terminating resistor R22 one end of transformator T1, other end connecting resistance R23 one end; Under 1 foot of the 2 foot insulating gate type field effect tube Q2 of insulating gate type field effect tube Q1 and transformator 21 foot; The other end of 3 foot connecting resistance R22, R23 of insulating gate type field effect tube Q1; The other end of 3 foot connecting resistance K24, R25 of insulating gate type field effect tube Q2; One end of 3 foot connecting resistance R26, R27 of insulating gate type field effect tube Q3; The two ends of the secondary line level circle T1-4 of another termination transformator T1 of resistance R26, R27; One end of 3 foot connecting resistance R28, R29 of insulating gate type field effect tube Q4; The other end of resistance R28, R29 connects the two ends of the secondary coil T1-5 of transformator T1 respectively; 1 foot of negative feedback A connects the resistance R17 one end in A amplifying circuit U1D1-1; 2 feet connect 1 foot of current PI D regulating circuit U1A1-5, and 3 feet connect 3 feet of variable resistance VR1; 1 foot of variable resistance VR1 connects+10V power supply, 2 foot ground connection; One end of transient state killer tube TVS is connected with SG3525 chip periphery circuit 1-4; SG3525 chip periphery circuit 1-4 is connected with overvoltage crowbar U2E1-8; Electric current P1D regulating circuit U1A1-5 is connected with automatic ruling circuit U 1C1-3; Automatic ruling circuit U 1C1-3 is connected with voltage P1D regulating circuit U1B1-2 and follower circuit U1E1-7.
Described A amplifying circuit U1D1-1, is made up of TL064 operational amplifier U1D and resistance R14, R16, R17, R18; One end of the 12 foot connecting resistance R17 of operational amplifier U1D, one end of 13 foot connecting resistance R18 and R16, the other end of 14 foot connecting resistance R14 one end and R16; The other end ground connection of resistance R18.
Described B amplifying circuit U2D1-6, is made up of TL064 operational amplifier U2D and resistance R15, R19, R20; The other end of the 12 foot connecting resistance R21 of TL064 operational amplifier U3D, one end of 13 foot connecting resistance R19, R20,4 feet meet power supply+VCC, and 11 feet meet power supply-UCC, 14 foot connecting resistance R15 one end and the resistance R20 other end; Resistance R19 other end ground connection.
Described voltage PID regulating circuit U1B1-2, is made up of TL064 operational amplifier U1B, capacitor C3, C4 and resistance R5 ~ R8; 7 feet of TL064 operational amplifier U1B connect the negative pole of the diode D2 in capacitor C4 one end and automatic ruling circuit 1-3, one end of 6 foot connecting resistance R5, R7 and capacitor C3, one end of 5 foot connecting resistance R8; The interface of another termination SIM32F103 single-chip microcomputer 6 of resistance R8; The other end of the other end connecting resistance R6 of capacitor C3; Resistance 5 other end is connected with the capacitor C4 other end.
Described current PI D adjuster circuit U1A1-5, be made up of TL064 operational amplifier U1A, capacitor C1, C2 and resistance R1 ~ R4,1 foot of TL064 operational amplifier U1A connects the negative pole of the diode D1 in capacitor C1 one end and automatic ruling circuit 1-3,11 feet meet power supply+VCC, 4 feet meet power supply-UCC, one end of 3 foot connecting resistance R1, R4 and capacitor C2,2 foot connecting resistance R2 one end; The interface of another termination SIM32F103 single-chip microcomputer of resistance R2; The other end of capacitor C2 is connected with the resistance R3 other end.
Described automatic ruling circuit U 1C1-3, is made up of TL064 operational amplifier U1C, diode D1, D2 and resistance R9, R10, R11; The one end of resistance R12 in 8 foot connecting resistance R10 one end of TL064 operational amplifier U1C and SG3525 chip periphery circuit 1-4, the positive pole of the 9 foot connecting resistance R10 other ends, resistance R11 one end and two pole D1, D2,10 foot connecting resistance R9 one end; Resistance R9 other end ground connection; Another termination power of resistance R11-VCC.
Described SG3525 chip periphery circuit 1-4, is made up of SG3525 chip U2 and resistance R12, R13; 13,15 feet of SG3525 chip U2 meet power supply+VCC, the 9 foot connecting resistance R12 other ends, and 5,7 feet connect one end of capacitor C5,6 foot connecting resistance R13 one end, 1,2,12 foot ground connection; Resistance R13 other end ground connection; Capacitor C5 other end ground connection.
Described follower circuit U1E1-7, is made up of TL064 operational amplifier U1E, capacitor C17, C18 and resistance R36, R37; The 1 foot connecting resistance R37 of TL064 operational amplifier U1E and one end of capacitor C18,2 feet connect the capacitor C18 other end and resistance R36 one end, and 3 feet connect 8 feet of TL064 operational amplifier U1C in automatic ruling circuit 1-3; The other end of resistance R36, R37 connects with capacitor C17 one end and connects with 8 feet of resistance R12, TL064 operational amplifier U1C in SG3525 chip periphery circuit 1-4; Capacitor C17 other end ground connection.
Described overvoltage crowbar U2E1-8, is made up of TL064 operational amplifier U2E, diode DN+2, capacitor C19, C20, C21, resistance R37 ~ R41 and variable resistance VR3; 5 foot connecting resistance R41, R39, R40 of TL064 operational amplifier U2E and one end of capacitor C19,6 feet connect capacitor C21 and resistance R38 one end, and 7 feet connect the positive pole of capacitor C20 one end, the resistance R41 other end and diode DN+2; Capacitor C20 other end ground connection, 3 feet of another termination variable resistance of resistance R38 VR3; 1 foot of variable resistance VR3 meets power supply VSS, 2 foot connecting resistance R37 one end; The other end of resistance R37 and capacitor C21 connects and ground connection; The resistance R21 other end in another termination B amplifying circuit U2D1-6 of resistance R39; The negative pole of diode DN+2 connects 9 feet of the SG3525PWM chip U2 of SG3525 chip periphery circuit 1-4.
Described LC resonance circuit 2, is made up of high-voltage DC power supply E, capacitor C22 ~ C27, inductance L 1 ~ L6 and K switch; Resistance R42, power supply L1 ~ L6, K switch and resistance R43 is in series with successively, shnt capacitor C22 ~ C27 between the both positive and negative polarity of high-voltage DC power supply E.
LS resonance circuit 2 forms a network LC1 by inductance L 1, L2, L3 and capacitor C22, C23, C23, forms a network LC2 by inductance L 4, L5, L6 and capacitor C25, C26, C27.
Select gas spark switch 3 in systems in which, this switch wide ranges, conductive electric current are large, flexible structure, making are simple, it has bears high pressure resistant, long service life, inductance and the low characteristic of shake, is used widely in pulse power power device.
Current transformer 5 is elementary is 1 circle, secondary is 100 circles, secondary parallel 500 Ω resistance, obtaining signal sends to the enumerator of the MM74C93 in SIM32F103 single-chip microcomputer to realize pulse number technical functionality, and number is reached predetermined value by SIM32F103 single-chip microcomputer 6 communication, transmission high level, to high voltage control signal plate, produces and signal can be made to do the shutoff process of high voltage power supply.Complete the counting output function of high-voltage pulse with this, carry out mediates tumor cell electric field intensity, the adjustment of radiated time and amount thereof, reach the therapeutic effect of anticipation.Above various functions completes automatically by SIM32F103 single-chip microcomputer 6 and the control sequence worked out.
The operation principle of this invention is: high-voltage DC power supply 1 is used for providing high direct voltage to LC resonance circuit 2, to LC1, LC2 network charges, when reaching the value of gas spark switch 3 conducting, the tumor for the treatment of is given at load 4() end generation high voltage pulse waveform, fetch pulse signal by load 4 current detecting enter rectification and do signal processing, obtain a low pressure high level signal to the MM74C93 computer in SIM32F103 single-chip microcomputer 6, for the technological accumulation of pulse signal, when reaching counting accumulated value, start high pressure and turn off control signal, the given control end determining high-voltage direct current 1, thus turn off producing of high-voltage direct current 1, make the impulse waveform of switching off load 4 end.
The slim contained high fdrequency component of high-voltage pulse will contribute to electric treatment effect in tumor cell, improve apoptosis of tumor cells rate further, and effectively the induction inhibition tumor cell cycle changes, and reaches the object of Tumor suppression tissue growth.The pulse amplitude of high voltage power supply is adjustable simultaneously, and mean power is adjustable, and high-voltage pulse number is adjustable, and treatment time is adjustable, to adapt to the treatment of heterogeneity tumor.
This invention succeed in developing by for the mankind pain controlled to malignant tumor started a new approach, for medical science makes tremendous contribution.
Claims (10)
1. a tumor nanosecond pulse electric therapeutic instrument, comprise current transformer (5), single-chip microcomputer (6) and gas spark switch (3), it is characterized in that single-chip microcomputer (6) and high voltage direct current source circuit (1) UNICOM, high voltage direct current source circuit (1) and LC resonance circuit (2) UNICOM, LC resonance circuit (2) and gas spark switch (3) UNICOM; High voltage direct current source circuit (1) comprises NC22OV power supply and is connected with 1,2 feet of KBU8104 rectifier bridge, 3 feet of KBU8104 rectifier bridge connect 1 foot of capacitor C6 one end and insulating gate type field effect tube Q1, Q3, and 4 feet connect secondary T1-3, the T1-5 of transformator T1, resistance R25, R29,2 feet of insulating gate type field effect tube Q2, Q4 and the other end of capacitor C6 and ground; The two ends of primary coil T1-1 two termination Zener diode TVS of transformator T1 and one end of capacitor C17; Difference connecting resistance R26, R27 one end, two ends of transformator T1 secondary coil T1-4 and 2 feet of transformator T2,3 feet of another termination insulating gate type field effect tube Q3 of resistance R26, R27; Transformer secondary coil T1-5 other end connecting resistance R28 one end, 3 feet of another termination insulating gate type field effect tube of resistance R28, R29 Q4; Connecting resistance R22, resistance R23 one end respectively, secondary coil T1-2 two ends of transformator T2; 1 foot of insulating gate type field effect tube Q2 connects the other end of 2 feet of insulating gate type field effect tube Q1,1 foot of transformator T2 and resistance R23; 3 feet of transformator T2 meet A amplifying circuit U1D(1-1) in the other end of resistance R17, capacitor C11, C12, resistance R30 and diode D5 one end; The capacitor C11 other end connecting resistance R30 other end and ground; Another termination of capacitor C12 multiple diode D3, D4 ... .Dn, one end of Dn+1; 4 feet of transformator T2 connect one end of capacitor C8; Another terminating diode D5, D3 of capacitor C8 and one end of capacitor C9; The other end of another termination multiple diode D4, Dn of capacitor C9 and one end of capacitor C10; Another terminating diode Dn+1 of capacitor C10, resistance R31 one end, resistance R31 connects multiple resistance R32 ~ Rn; Other end connecting resistance R33, the capacitor C7 of resistance Rn and B amplifying circuit U2D(1-6) in resistance R21 one end; The other end ground connection of voltage sampling resistor R33 and capacitor C7; 2 feet of negative feedback B connect voltage PID actuator U1B(1-2) 7 feet, 3 feet connect 3 feet of variable resistance UR2; 1 foot of variable resistance UR2 connects+10V power supply, 2 foot ground connection; Secondary coil T1-2 mono-terminating resistor R22 one end of transformator T1, other end connecting resistance R23 one end; 2 feet of insulating gate type field effect tube Q1 connect 1 foot of insulating gate type field effect tube Q2 and 1 foot of transformator T2; The other end of 3 foot connecting resistance R22, R23 of insulating gate type field effect tube Q1; The other end of 3 foot connecting resistance K24, R25 of insulating gate type field effect tube Q2; One end of 3 foot connecting resistance R26, R27 of insulating gate type field effect tube Q3; The two ends of the secondary line level circle T1-4 of another termination transformator T1 of resistance R26, R27; One end of 3 foot connecting resistance R28, R29 of insulating gate type field effect tube Q4; The other end of resistance R28, R29 connects the two ends of the secondary coil T1-5 of transformator T1 respectively; 1 foot of negative feedback A meets A amplifying circuit U1D(1-1) in resistance R17 one end; 2 feet meet current PI D regulating circuit U1A(1-5) 1 foot, 3 feet connect 3 feet of variable resistance VR1; 1 foot of variable resistance VR1 connects+10V power supply, 2 foot ground connection; The other end of capacitor C17 is connected with SG3525 chip periphery circuit (1-4) with one end of transient state killer tube TVS; SG3525 chip periphery circuit (1-4) and overvoltage crowbar U2E(1-8) be connected; Electric current P1D regulating circuit U1A(1-5) with automatic ruling circuit U 1C(1-3) be connected; Automatic ruling circuit U 1C (1-3) and voltage P1D regulating circuit U1B(1-2) and follower circuit U1E(1-7) be connected.
2. tumor nanosecond pulse electric therapeutic instrument according to claim 1, is characterized in that described A amplifying circuit U1D(1-1), be made up of TL064 operational amplifier U1D and resistance R14, R16, R17, R18; One end of the 12 foot connecting resistance R17 of operational amplifier U1D, one end of 13 foot connecting resistance R18 and R16, the other end of 14 foot connecting resistance R14 one end and R16; The other end ground connection of resistance R18.
3. tumor nanosecond pulse electric therapeutic instrument according to claim 1, is characterized in that described B amplifying circuit U2D(1-6), be made up of TL064 operational amplifier U2D and resistance R15, R19, R20; The other end of the 12 foot connecting resistance R21 of TL064 operational amplifier U2D, one end of 13 foot connecting resistance R19, R20,4 feet meet power supply+UCC, and 11 feet meet power supply-VCC, 14 foot connecting resistance R15 one end and the resistance R20 other end; Resistance R19 other end ground connection.
4. tumor nanosecond pulse electric therapeutic instrument according to claim 1; it is characterized in that described voltage PID regulating circuit U1B(1-2); be made up of TL064 operational amplifier U1B, capacitor C3, C4 and resistance R5 ~ R8; 7 feet of TL064 operational amplifier U1B connect the negative pole of the diode D2 in capacitor C4 one end and automatic ruling circuit (1-3); one end of 6 foot connecting resistance R5, R7 and capacitor C3, one end of 5 foot connecting resistance R8; The interface of another termination SIM32F103 single-chip microcomputer (6) of resistance R8; The other end of the other end connecting resistance R6 of capacitor C3; Resistance 5 other end is connected with the capacitor C4 other end.
5. tumor nanosecond pulse electric therapeutic instrument according to claim 1, it is characterized in that described current PI D adjuster circuit U1A(1-5), be made up of TL064 operational amplifier U1A, capacitor C1, C2 and resistance R1 ~ R4,1 foot of TL064 operational amplifier U1A connects the negative pole of the diode D1 in capacitor C1 one end and automatic ruling circuit (1-3), 11 feet meet power supply+VCC, 4 feet meet power supply-VCC, one end of 3 foot connecting resistance R1, R4 and capacitor C2,2 foot connecting resistance R2 one end; The interface of another termination SIM32F103 single-chip microcomputer of resistance R2; The other end of capacitor C2 is connected with the resistance R3 other end.
6. tumor nanosecond pulse electric therapeutic instrument according to claim 1, is characterized in that described automatic ruling circuit U 1C(1-3), be made up of TL064 operational amplifier U1C, diode D1, D2 and resistance R9, R10, R11; The one end of resistance R12 in 8 foot connecting resistance R10 one end of TL064 operational amplifier U1C and SG3525 chip periphery circuit (1-4), the positive pole of the 9 foot connecting resistance R10 other ends, resistance R11 one end and two pole D1, D2,10 foot connecting resistance R9 one end; Resistance R9 other end ground connection; Another termination power of resistance R11-VCC.
7. tumor nanosecond pulse electric therapeutic instrument according to claim 1, is characterized in that described SG3525 chip periphery circuit (1-4), is made up of SG3525 chip U2, resistance R12, R13 and capacitor C5; 13,15 feet of SG3525 chip U2 meet power supply+VCC, the 9 foot connecting resistance R12 other ends, and 5,7 feet connect one end of capacitor C5,6 foot connecting resistance R13 one end, 1,2,12 foot ground connection; Resistance R13 other end ground connection; Capacitor C5 other end ground connection.
8. tumor nanosecond pulse electric therapeutic instrument according to claim 1, is characterized in that described follower circuit U1E(1-7), be made up of TL064 operational amplifier U1E, capacitor C17, C18 and resistance R36, R37; The 1 foot connecting resistance R37 of TL064 operational amplifier U1E and one end of capacitor C18,2 feet connect the capacitor C18 other end and resistance R36 one end, and 3 feet connect 8 feet of TL064 operational amplifier U1C in automatic ruling circuit (1-3); The other end of resistance R36, R37 connects with capacitor C17 one end and connects with 8 feet of resistance R12, TL064 operational amplifier U1C in SG3525 chip periphery circuit (1-4); Capacitor C17 other end ground connection.
9. tumor nanosecond pulse electric therapeutic instrument according to claim 1, it is characterized in that described overvoltage crowbar U2E(1-8), be made up of TL064 operational amplifier U2E, diode DN+2, capacitor C19, C20, C21, resistance R37 ~ R41 and variable resistance VR3; 5 foot connecting resistance R41, R39, R40 of TL064 operational amplifier U2E and one end of capacitor C19,6 feet connect capacitor C21 and resistance R38 one end, and 7 feet connect the positive pole of capacitor C20 one end, the resistance R41 other end and diode DN+2; Capacitor C20 other end ground connection, 3 feet of another termination variable resistance of resistance R38 VR3; 1 foot of variable resistance VR3 meets power supply VSS, 2 foot connecting resistance R37 one end; The other end of resistance R37 and capacitor C21 connects and ground connection; Another termination B amplifying circuit U2D(1-6 of resistance R39) in the resistance R21 other end; The negative pole of diode DN+2 connects 9 feet of the SG3525 chip U2 of SG3525 chip periphery circuit (1-4).
10. tumor nanosecond pulse electric therapeutic instrument according to claim 1, is characterized in that described LC resonance circuit (2), is made up of high-voltage DC power supply E, capacitor C22 ~ C27, inductance L 1 ~ L6 and K switch; Resistance R42, inductance L 1 ~ L6, K switch and resistance R43 is in series with successively, shnt capacitor C22 ~ C27 between the both positive and negative polarity of high-voltage DC power supply E.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510217295.2A CN104784814B (en) | 2015-05-04 | 2015-05-04 | Tumour nanosecond pulse electro-therapeutic apparatus |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510217295.2A CN104784814B (en) | 2015-05-04 | 2015-05-04 | Tumour nanosecond pulse electro-therapeutic apparatus |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN104784814A true CN104784814A (en) | 2015-07-22 |
| CN104784814B CN104784814B (en) | 2017-09-05 |
Family
ID=53550285
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201510217295.2A Active CN104784814B (en) | 2015-05-04 | 2015-05-04 | Tumour nanosecond pulse electro-therapeutic apparatus |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN104784814B (en) |
Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1089172A (en) * | 1993-01-09 | 1994-07-13 | 张进锁 | Touching-type instrument for invigorating channels and collaterals |
| KR20090098541A (en) * | 2008-03-14 | 2009-09-17 | (주)메디즌 | Electrical treatment equipment with glove type electrode |
| US8688240B1 (en) * | 2012-10-30 | 2014-04-01 | Mitosis Inc. | Device for neuro-physiologic stimulation |
| CN103977500A (en) * | 2014-05-25 | 2014-08-13 | 重庆新大地电子有限公司 | Low-voltage negative-potential physiotherapy electrode device |
| CN204734856U (en) * | 2015-05-04 | 2015-11-04 | 大连捷众科技有限公司 | Tumour nanosecond pulse electro -therapeutic apparatus |
-
2015
- 2015-05-04 CN CN201510217295.2A patent/CN104784814B/en active Active
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1089172A (en) * | 1993-01-09 | 1994-07-13 | 张进锁 | Touching-type instrument for invigorating channels and collaterals |
| KR20090098541A (en) * | 2008-03-14 | 2009-09-17 | (주)메디즌 | Electrical treatment equipment with glove type electrode |
| US8688240B1 (en) * | 2012-10-30 | 2014-04-01 | Mitosis Inc. | Device for neuro-physiologic stimulation |
| CN103977500A (en) * | 2014-05-25 | 2014-08-13 | 重庆新大地电子有限公司 | Low-voltage negative-potential physiotherapy electrode device |
| CN204734856U (en) * | 2015-05-04 | 2015-11-04 | 大连捷众科技有限公司 | Tumour nanosecond pulse electro -therapeutic apparatus |
Also Published As
| Publication number | Publication date |
|---|---|
| CN104784814B (en) | 2017-09-05 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN101085391B (en) | Device for inducing tumor cell apoptosis by high-voltage nanosecond pulse | |
| CN103560572B (en) | A kind of implantable cardiac pacemaker magnetic coupling resonance wireless charging device | |
| CN103656857B (en) | A kind of Portable low-temp plasma sterilization, beauty appliance | |
| CN104902835A (en) | Electromedical device | |
| CN207744615U (en) | A kind of intelligent control trapping lamp | |
| CN204734856U (en) | Tumour nanosecond pulse electro -therapeutic apparatus | |
| MX2022004584A (en) | Devices and methods for modulating immune system activity in a cancer patient and treating cancer. | |
| CN104784814A (en) | Tumor nanosecond impulse electro-therapeutic apparatus | |
| CN202724455U (en) | Electronic acupuncture and moxibustion therapeutic apparatus | |
| CN204972696U (en) | High -efficient air anion instrument | |
| CN107320842B (en) | Low-frequency ultrasonic medicine guide instrument | |
| CN106451626B (en) | Wireless charging device of implanted electronic stimulator | |
| CN108392736A (en) | A kind of device and method for repairing the separation of postpartum rectus aabdominis | |
| CN203915774U (en) | Low pressure nagative potential physiogherapy electrode device | |
| CN210472587U (en) | Multifunctional three-oxygen vibration device | |
| CN208525470U (en) | It is a kind of make mobile power source instantaneously kill the equipment that disappears | |
| CN203208545U (en) | Temperature control circuit of TDP treatment plate | |
| CN204069430U (en) | A kind of therapeutic room's control system based on ultraviolet LED | |
| CN207785664U (en) | The embedded integral type implantable heart pacer of wireless charging function | |
| CN103977500A (en) | Low-voltage negative-potential physiotherapy electrode device | |
| CN108721720B (en) | Implantable heart auxiliary blood supply device based on wireless power transmission | |
| CN105362014A (en) | Luxurious electric bed | |
| CN205052580U (en) | Novel intelligence solar energy insecticidal lamp | |
| CN209378312U (en) | A kind of novel portable neuromuscular electric stimulation therapy device | |
| CN2260627Y (en) | Electrode with protecting device for external radio-frequency prostate therapeutical instrument |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| GR01 | Patent grant | ||
| GR01 | Patent grant | ||
| CB03 | Change of inventor or designer information | ||
| CB03 | Change of inventor or designer information |
Inventor after: Fan Yinhai Inventor after: Hu Dongjiang Inventor after: Wang Chao Inventor before: Geng Meiru |