CN104784287A - Olfactory stimulation solution for early prevention of Alzheimer disease and preparation method of olfactory stimulation solution - Google Patents
Olfactory stimulation solution for early prevention of Alzheimer disease and preparation method of olfactory stimulation solution Download PDFInfo
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- CN104784287A CN104784287A CN201510208002.4A CN201510208002A CN104784287A CN 104784287 A CN104784287 A CN 104784287A CN 201510208002 A CN201510208002 A CN 201510208002A CN 104784287 A CN104784287 A CN 104784287A
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Abstract
The invention discloses an olfactory stimulation solution for early prevention of Alzheimer disease and a preparation method of the olfactory stimulation solution. The olfactory stimulation solution disclosed by the invention specifically comprises the following components in parts by volume: 1-10 parts of lavender essential oil, 1-3 parts of rose essential oil, 1-6 parts of essential oil of jasminum, 1-6 parts of chamomile essential oil and 1-6 parts of peppermint essential oil. According to the olfactory stimulation solution disclosed by the invention, the olfactory center of the brain is stimulated by virtue of intranasal delivery via the olfactory pathway, and the aims of early effectively preventing senile dementia and improving the memory function and cognitive function of the old are achieved. The olfactory stimulation solution is safe and convenient to use, does not have any toxic or side effect and can be matched with other prevention methods to be used for a long time.
Description
Technical field
The invention belongs to medical art, relate to a kind of olfactory stimulation liquid for early prevention Alzheimer and preparation method thereof.
Background technology
Alzheimer (Alzheimer ' s disease, be called for short AD, have another name called senile dementia) be geratic period common one group of chronic progressive external mental deterioration disease, in the spectrum of disease and death notation of old people, occupy important position.Think at present, senile dementia is one group of syndrome of the senior cerebral disorder caused by organic lesion that is chronic or Progressive symmetric erythrokeratodermia brain structure, it is lasting, the comprehensive hypophrenia that patient occurs under the state of Consciousness, show as memory, computing power, judgment, attention, abstract thinking ability, language function go down, emotion and behavior disorder, live on one's own life and ability to work is lost.
International Alzheimer community (Alzheimer ' s Disease International, be called for short ADI) point out in the report of announcement in 2009: global patients of senile dementia is more than 3,500 ten thousand then, and along with the aging of population, estimate that global patients of senile dementia number is often crossed and will double for 20 years.To the year two thousand fifty, the puzzlement that the whole world will have 1.15 hundred million people can be subject to this disease.Dull-witted not only have a strong impact on the quality of life of old people, return patient home and society brings white elephant.
But the cause of disease of senile dementia and control thereof are complicated problems.Because the middle and advanced stage therapeutic effect of dementia is not good, early prevention hypophrenia has become people's focus, mainly contains the aspects such as pharmaceutical intervention, nutritional intervention, cognitive training, motion intervention, acupuncture and moxibustion therapy at present available.Studies have found that in recent years, old olfactory sensation identification hypofunction may be one of dysfunction of patients of senile dementia comparatively early appearance.Start with from the side, likely for the Prevention and Curation of Alzheimer provides effective ways and means.
Summary of the invention
For above-mentioned situation, the invention provides a kind of olfactory stimulation liquid of early prevention Alzheimer.This olfactory stimulation liquid comprises multiple natural essential oil, and per nasal olfactory pathway gives patient olfactory stimulation.By crowd's experimentation, this olfactory stimulation liquid effectively can prevent senile dementia and slow down cognitive function decline.
Specifically, the invention provides a kind of olfactory stimulation liquid of early prevention Alzheimer, it comprises the following component in volume parts: 1 ~ 10 part of Herba Lysimachiae foenum-graeci quintessence oil, 1 ~ 3 part of Flos Rosae Rugosae quintessence oil, 1 ~ 6 part of jasmin quintessence oil, 1 ~ 6 part of chamomile essential oil and 1 ~ 6 part of Peppermint essential oil.
In a preferred technical scheme, described olfactory stimulation liquid comprises the following component in volume parts: 1 ~ 6 part of Herba Lysimachiae foenum-graeci quintessence oil, 1 ~ 2 part of Flos Rosae Rugosae quintessence oil, 1 ~ 3 part of jasmin quintessence oil, 1 ~ 3 part of chamomile essential oil and 1 ~ 3 part of Peppermint essential oil.
In a preferred technical scheme, described olfactory stimulation liquid comprises the following component in volume parts: 3 parts of Herba Lysimachiae foenum-graeci quintessence oil, 1 part of Flos Rosae Rugosae quintessence oil, 2 parts of jasmin quintessence oils, 2 parts of chamomile essential oil and 2 parts of Peppermint essential oil.
On the other hand, the invention provides a kind of method of the olfactory stimulation liquid for the preparation of above-mentioned early prevention Alzheimer, it comprises the following steps: to measure each component according to required volume and predetermined volume parts, again each component after measuring mixed and stirs, obtaining the olfactory stimulation liquid of early prevention Alzheimer.
Ultimate principle of the present invention: by a kind of olfactory stimulation liquid, per nasal olfactory pathway stimulates brain olfactory center, to make brain olfactory center excited; Meanwhile, drive cerebral cortex excited, the useless sexual disorder of prevention aging brains, reach the object of effectively preventing senile dementia and improving cognitive function.This olfactory stimulation liquid is the mixture of chemical compound lot, mainly contains terpene hydrocarbons, arene, alcohols, aldehydes, ketone, ethers, esters and phenols etc., has stimulation to the olfactory sensation of people.Wherein:
Herba Lysimachiae foenum-graeci quintessence oil stimulates olfactory nerves by breath, and stimulation is reached brain centres by olfactory nerves, and brain produces excited, plays and regulates neururgic function;
Flos Rosae Rugosae quintessence oil is Pure natural plant essential oil, mainly contains following functions: fragrant, after naturally fragrance enters brain via olfactory nerves, can stimulate anterior lobe of cerebrum secreting hormone, make spirit present the state of the most comfortable;
Jasmin quintessence oil can console psychology, can produce sensation that is optimistic and euphoria;
Chamomile essential oil has sedation;
Peppermint essential oil can pacify indignation, hysteria and frightened state, and spirit can be made to improve.
Due to the utilization of technique scheme, the present invention compared with prior art has the following advantages:
(1) olfactory stimulation liquid per nasal olfactory pathway of the present invention stimulates brain olfactory center, make brain olfactory center excited, drive cerebral cortex excited, the useless sexual disorder of prevention aging brains simultaneously, reach and effectively prevent senile dementia in early days, improve the object of senile memory and cognitive function;
(2) olfactory stimulation liquid of the present invention has safe and convenient to use, the advantage had no side effect, and can coordinate other prevention method life-time service;
(3) by often using olfactory stimulation liquid of the present invention, effectively can prevent the generation of senile dementia in early days, this is to the life quality improving old people, alleviate family, society and national each side burden significant.
Detailed description of the invention
Further describe the present invention below in conjunction with specific embodiments.
Embodiment 1: specification is the preparation of the olfactory stimulation liquid of 30mL.
Measure Herba Lysimachiae foenum-graeci quintessence oil 10mL, Flos Rosae Rugosae quintessence oil 2mL, jasmin quintessence oil 6mL, chamomile essential oil 6mL, Peppermint essential oil 6mL, said components mixed and stirs, to obtain final product.
Embodiment 2: specification is the preparation of the olfactory stimulation liquid of 15mL.
Measure Herba Lysimachiae foenum-graeci quintessence oil 6mL, Flos Rosae Rugosae quintessence oil 1mL, jasmin quintessence oil 2mL, chamomile essential oil 3mL, Peppermint essential oil 3mL, said components mixed and stirs, to obtain final product.
Embodiment 3: specification is the preparation of the olfactory stimulation liquid of 10mL.
Measure Herba Lysimachiae foenum-graeci quintessence oil 3mL, Flos Rosae Rugosae quintessence oil 1mL, jasmin quintessence oil 2mL, chamomile essential oil 2mL, Peppermint essential oil 2mL, said components mixed and stirs, to obtain final product.
Embodiment 4: olfactory stimulation liquid improves the effect analysis of cognitive function.
Experimental subject and method:
Select old people 60 people (79.9 years old mean age) having cognitive impairment for 75 ~ 85 years old, men and women half and half, is divided into seminar 1,2,3 groups at random, adopts the olfactory stimulation liquid 2 ~ 3 times of different ratio every day, implements 12 months, implements fore-and-aft survey cognitive competence; Select old people 20 people (79.3 years old mean age) having cognitive impairment for 75 ~ 85 years old, men and women half and half, as a control group, measures twice cognitive competence simultaneously simultaneously, observation and comparison four groups of cognitive competence changes, concrete cognitive competence change (
± s) result as shown in table 1.
The effectiveness comparison of the olfactory stimulation liquid of table 1, use particular formulation.
| Group | Matched group | Embodiment 1 group | Embodiment 2 groups | Embodiment 3 groups | P value |
| Cognitive competence changes | 1.15±1.22 | 2.85±1.34 | 2.97±1.55 | 3.05±1.71 | P<0.05 |
As seen from the above table, by Montreal Scale and questionnaire, the old people of cognitive impairment is after often using olfactory stimulation liquid of the present invention, and cognitive competence there occurs change; Compared with matched group, seminar's 1,2,3 groups of cognitive competence mark tools are significantly improved, difference significance (P < 0.05), and do not have difference between seminar 1,2,3 groups.This result shows, adopts olfactory stimulation liquid of the present invention, has the effect improving old cognitive competence, Alzheimer can occur early prevention old people.
Claims (4)
1. an olfactory stimulation liquid for early prevention Alzheimer, it comprises the following component in volume parts: 1 ~ 10 part of Herba Lysimachiae foenum-graeci quintessence oil, 1 ~ 3 part of Flos Rosae Rugosae quintessence oil, 1 ~ 6 part of jasmin quintessence oil, 1 ~ 6 part of chamomile essential oil and 1 ~ 6 part of Peppermint essential oil.
2. the olfactory stimulation liquid of early prevention Alzheimer according to claim 1, it is characterized in that, described olfactory stimulation liquid comprises the following component in volume parts: 1 ~ 6 part of Herba Lysimachiae foenum-graeci quintessence oil, 1 ~ 2 part of Flos Rosae Rugosae quintessence oil, 1 ~ 3 part of jasmin quintessence oil, 1 ~ 3 part of chamomile essential oil and 1 ~ 3 part of Peppermint essential oil.
3. the olfactory stimulation liquid of early prevention Alzheimer according to claim 2, it is characterized in that, described olfactory stimulation liquid comprises the following component in volume parts: 3 parts of Herba Lysimachiae foenum-graeci quintessence oil, 1 part of Flos Rosae Rugosae quintessence oil, 2 parts of jasmin quintessence oils, 2 parts of chamomile essential oil and 2 parts of Peppermint essential oil.
4. the method for the preparation of the olfactory stimulation liquid of the early prevention Alzheimer according to any one of the claims, it comprises the following steps: to measure each component, again each component after measuring mixed and stirs, obtaining the olfactory stimulation liquid of early prevention Alzheimer.
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN105477008A (en) * | 2015-12-16 | 2016-04-13 | 甘肃东方天润玫瑰科技发展有限公司 | Application of rose polysaccharides in preparing medicine for treating Alzheimer's disease |
| CN105521075A (en) * | 2015-12-16 | 2016-04-27 | 甘肃东方天润玫瑰科技发展有限公司 | Rose essential oil for treating Alzheimer disease and application of rose essential oil |
| CN108553651A (en) * | 2018-05-17 | 2018-09-21 | 宁波市第二医院 | A kind of preparation method and applications for smelling liquid |
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| CN102228454A (en) * | 2011-05-06 | 2011-11-02 | 安徽丰乐香料有限责任公司 | Brain targeting via olfactory pathway fragrant essential oil compound and monomer pharmaceutical composition with functions for preventing and treating brain atrophy and activating brain cells |
| CN103002902A (en) * | 2010-05-19 | 2013-03-27 | 皮肤生命株式会社 | Cosmetic composition containing a cypress essential oil complex as an active ingredient for enhancing memory and improving cognitive dysfunction |
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2015
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| CN103002902A (en) * | 2010-05-19 | 2013-03-27 | 皮肤生命株式会社 | Cosmetic composition containing a cypress essential oil complex as an active ingredient for enhancing memory and improving cognitive dysfunction |
| CN102228454A (en) * | 2011-05-06 | 2011-11-02 | 安徽丰乐香料有限责任公司 | Brain targeting via olfactory pathway fragrant essential oil compound and monomer pharmaceutical composition with functions for preventing and treating brain atrophy and activating brain cells |
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Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105477008A (en) * | 2015-12-16 | 2016-04-13 | 甘肃东方天润玫瑰科技发展有限公司 | Application of rose polysaccharides in preparing medicine for treating Alzheimer's disease |
| CN105521075A (en) * | 2015-12-16 | 2016-04-27 | 甘肃东方天润玫瑰科技发展有限公司 | Rose essential oil for treating Alzheimer disease and application of rose essential oil |
| CN105521075B (en) * | 2015-12-16 | 2017-12-05 | 甘肃东方天润玫瑰科技发展有限公司 | A kind of Rosa Damascana for treating Alzheimer's disease and its application |
| CN105477008B (en) * | 2015-12-16 | 2018-01-05 | 甘肃东方天润玫瑰科技发展有限公司 | Application of the rose polysaccharide in the medicine for preparing treatment Alzheimer's disease |
| CN108553651A (en) * | 2018-05-17 | 2018-09-21 | 宁波市第二医院 | A kind of preparation method and applications for smelling liquid |
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