CN104771542A - Oral drug for treating amenorrhea and preparation method of oral drug - Google Patents

Abstract

The invention discloses an oral drug for treating amenorrhea and a preparation method of the oral drug. The drug comprises the following components in parts by mass: 1-3 parts of astragalus from the northeast of China, 1-3 parts of radix codonopsis from the northwest of China, 1-3 parts of bleached atractylodes macrocephala, 1-3 parts of tuckahoe from Yunnan of China, 1-3 parts of whole angelica sinensis, 1-3 parts of radix paeoniae alba from Hangzhou of China, 1-3 parts of cuttle bones, 1-3 parts of dipsacus asper, 1-3 parts of prepared rhizoma cyperi, 1-3 parts of red radix bupleuri, 1-3 parts of costus roots, 1-3 parts of cinnamomum cassia and 1-3 parts of honey-fried licorice roots. The preparation method of the drug comprises the following steps of selecting first-grade astragalus from the northeast of China, radix codonopsis from the northwest of China, bleached atractylodes macrocephala, tuckahoe from Yunnan of China, whole angelica sinensis, radix paeoniae alba from Hangzhou of China, cuttle bones, dipsacus asper, prepared rhizoma cyperi, red radix bupleuri, costus roots, cinnamomum cassia and honey-fried licorice roots according to the mass part ratio, and respectively removing impurities and dust to obtain drugs for later use; and placing the drugs into purified water to soak for about half an hour, then, simultaneously placing the soaked drugs and a clarified liquid of the soaked drugs into a drug decocting machine, injecting cold boiled water 30mm more than the volumes of the drugs to decoct for the first time for 35 minutes, filtering the liquid medicine, then, injecting micro-warm boiled water again to decoct for the second time for 30 minutes, mixing and concentrating to form 1800ml of liquid traditional Chinese medicine with the concentration of 50%, bagging, sealing, and then, preserving the liquid traditional Chinese medicine in a refrigerator for later use.

Description

A kind of endo-medicine for the treatment of amenorrhea and preparation method thereof

Technical field

The present invention relates to field of Chinese herbal medicine technology, be specifically related to a kind of endo-medicine for the treatment of amenorrhea, particularly for the field of the endo-medicine and preparation method thereof of amenorrhea patients.

Background technology

Amenorrhea is symptom common in gynaecopathia, can be caused by various different reason.Usually amenorrhea is divided into constitutional and Secondary cases two kinds.All persons that do not pass through yet over 18 years old are called primary amenorrhea; After menarche, in any time before normal menopause (gestation or age of sucking except), menstruation apolipsis is called secondary amenorrhea more than 6 months persons.Such differentiation is artificial to a great extent, because the Fundamentals causing former and secondary amenorrhea may be identical sometimes.But when providing the clue of the cause of disease and prognosis, this division is valuable, such as most birth defect, comprise the abnormal development of ovary or Seedling Le Shi tissue, the amenorrhea caused is put into primary amenorrhea, and secondary amenorrhea majority is caused by acquired disease, and more easily treats.

So, just how finding a kind of endo-medicine effectively can treating amenorrhea, is the difficult problem that we medical personnel is badly in need of tackling key problems.

Summary of the invention

The object of this invention is to provide a kind of endo-medicine for the treatment of amenorrhea and preparation method thereof, to solve amenorrhea patients restorative problem early.This medicine is that have compatibility science, the efficacy of a drug is powerful with common Chinese herbal medicine for raw material, hit pathogenesis, fully demonstrate soothing the liver reach strongly fragrant, the Therapeutic Principle that activating the spleen stimulates the menstrual flow.

For reaching the object of foregoing invention, the technical solution adopted in the present invention is: provide a kind of endo-medicine for the treatment of amenorrhea and preparation method thereof, it is characterized in that, each component of described medicine and mass parts thereof are than as follows:

Radix Astragali (wine stir-fry) 1-3 part;

RADIX CODONOPSIS PILOSULAE from Northwest of China 1-3 part;

Bleaching art 1-3 part;

PORIA from Yunnan of China 1-3 part;

Radix Angelicae Sinensis 1-3 part;

Radix Paeoniae Alba (wine stir-fry) 1-3 part;

Os Sepiae 1-3 part;

Radix Dipsaci 1-3 part;

Rhizoma Cyperi (processed) 1-3 part;

RADIX BUPLEURI SCORZONERIFOLII 1-3 part;

Radix Aucklandiae (Radix Vladimiriae) 1-3 part;

Upper Cortex Cinnamomi 1-3 part;

Radix Glycyrrhizae Preparata 1-3 part.

According to the endo-medicine for the treatment of amenorrhea provided by the present invention, it is characterized in that, each component of described medicine and mass parts thereof are than as follows:

Radix Astragali (wine stir-fry) 1 part;

RADIX CODONOPSIS PILOSULAE from Northwest of China 1 part;

Bleaching art 1 part;

PORIA from Yunnan of China 1 part;

Radix Angelicae Sinensis 1 part;

Radix Paeoniae Alba (wine stir-fry) 1 part;

Os Sepiae 1 part;

Radix Dipsaci 1 part;

Rhizoma Cyperi (processed) 1 part;

RADIX BUPLEURI SCORZONERIFOLII 1 part;

Radix Aucklandiae (Radix Vladimiriae) 1 part;

Upper Cortex Cinnamomi 1 part;

Radix Glycyrrhizae Preparata 1 part.

A kind of endo-medicine for the treatment of amenorrhea and preparation method thereof, is characterized in that, described method comprises the steps:

A, the one-level Radix Astragali 1 part (wine stir-fry) selecting high-quality clean, RADIX CODONOPSIS PILOSULAE from Northwest of China 1 part, bleaching art 1 part, PORIA from Yunnan of China 1 part, Radix Angelicae Sinensis 1 part, Radix Paeoniae Alba 1 part (wine stir-fry), Os Sepiae 1 part, Radix Dipsaci 1 part, Rhizoma Cyperi (processed) 1 part, RADIX BUPLEURI SCORZONERIFOLII 1 part, Radix Aucklandiae (Radix Vladimiriae) 1 part, upper Cortex Cinnamomi 1 part, Radix Glycyrrhizae Preparata 1 part, stand-by after picking decontamination and dust respectively;

B, said medicine put into about water purification soaks half an hour, with osmotic drug degree of being organized as, then again the clear liquor of soaked medicine and soak medicine is put into boiling machine in the lump, the cold boiled water injecting medicine 30mm carries out first time decoction 35 minutes, after leaching medicinal liquid, re-inject tepor boiled water and carry out second time decoction 30 minutes, merge the herb liquid 1800 milliliters being condensed into 50%, enter in refrigerator fresh-keeping for subsequent use after packed sealing.

A kind of endo-medicine for the treatment of amenorrhea and preparation method thereof, is characterized in that, described instructions of taking is: divided by the herb liquid prepared and take for three days, every day potion, the morning, noon and afternoon service once, dosage 200 milliliters/time, taking medicine before meal, and 25-28 agent of taking medicine, disease obtains recovery from illness.

Medicine provided by the present invention is oral traditional Chinese medicine composition, and it for raw material, gives full play to the property of medicine of each component with common Chinese herbal medicine:

Radix Astragali (wine stir-fry), nature and flavor: sweet in the mouth, slightly warm in nature, have effect of invigorating the spleen and replenishing QI, are used for the treatment of weakness of the spleen and stomach, anorexia and loose stool, the disease of fatigue and weakness and diarrhea due to hypofunction of the spleen, chronic diarrhea proctoptosis etc.Radix Astragali has the function of strong, the kind tonifying the lung gas of QI invigorating power, breathe hard for the deficiency of the lung, the lazy speech of low voice, spiritlessness and weakness, disease easy to catch cold;

RADIX CODONOPSIS PILOSULAE from Northwest of China, nature and flavor: property is flat, sweet in the mouth, micro-acid, there is invigorating the spleen and replenishing QI, effect of spleen invigorating lung benefiting, be used for the treatment of deficiency of the spleen and lung, the cough of cardiopalmus of breathing hard, anorexia and loose stool, dyspnea due to deficiency, interior-heat quench one's thirst;

Bleaching art, nature and flavor: bitter, sweet, warm, have invigorating the spleen and benefiting QI, dampness diuretic, hidroschesis, antiabortive effect, are used for the treatment of insufficiency of the spleen lack of appetite, abdominal distention is had loose bowels, phlegm retention vertigo and palpitation, edema, spontaneous perspiration, frequent fetal movement;

PORIA from Yunnan of China, nature and flavor: sweet, light, flat, there is effect of eliminating dampness and diuresis, invigorating the spleen and regulating the stomach, mind tranquilizing and the heart calming, be used for the treatment of dysuria, edema distension, phlegm retention cough with dyspnea, vomiting, insufficiency of the spleen lack of appetite, have loose bowels, palpitation and restlessness, insomnia forgetfulness, seminal emission nebulousurine;

Radix Angelicae Sinensis, nature and flavor:, warm in nature, sweet in the mouth is pungent, there is benefiting blood and regulating blood circulation, menstruction regulating and pain relieving, moisturize effect of laxation, be used for the treatment of blood deficiency, shallow complexion, dizzy cardiopalmus, blood deficiency or have the pain cards such as the stagnant menoxenia of the stasis of blood, amenorrhea, dysmenorrhea, deficient cold type stomachache, angina pectoris, rheumatic arthralgia, traumatic injury concurrently;

Radix Paeoniae Alba (wine stir-fry), nature and flavor: bitter, acid, to be slightly cold, have nourish blood and seek, effect of relieving spasm to stop pain, yin fluid astringing suppressing the hyperactive liver, be used for the treatment of menoxenia, abdominal pain during menstruation, metrorrhagia, spontaneous perspiration, night sweat, side of body rib epigastric pain, limb pain twin, headache, dizzy;

Os Sepiae, nature and flavor: salty, puckery, tepor, have effect of dehumidifying, antacid, hemostasis, sore, are used for the treatment of stomachache acid regurgitation, tell, be defeated in battle, hematemesis, have blood in stool, bleeding not during menses, amenorrhea due to blood depletion, Fu Tong mass in the abdomen, intermittent fever of deficiency type dysentery, the rotten skin ulcer of the erosion of the vulva;

Radix Dipsaci, nature and flavor: toil, tepor, have effect of invigorating the liver and kidney, reuniting the fractured tendons and bones, blood circulation regulating, be used for the treatment of aching pain in waist and back, the foot and knee being feeble, vaginal bleeding during pregnancy, metrorrhagia, leukorrhagia, seminal emission, traumatic injury, incised wound, anal fistula, carbuncle skin ulcer swell;

Rhizoma Cyperi (processed), nature and flavor: the micro-hardship of property, micro-sweet, have effect of dredging irritability, regulating menstruation, are used for the treatment of the diseases such as gynecological's menoxenia, dyspepsia, abdominal distention stomachache;

RADIX BUPLEURI SCORZONERIFOLII, nature and flavor: bitter in the mouth, pungent, cold nature, having induces sweat brings down a fever, effect of dispersing the stagnated live-QI to relieve the stagnation of QI, elevate a turnable ladder yang-energy, is used for the treatment of fever caused by exogenous pathogens, alternate attack of chill and fever, malaria, hypochondriac pain due to stagnation of liverQI mammary swelling, headache dizziness, menoxenia, the proctoptosis of collapse of QI, uterine prolapse, gastroptosis;

Radix Aucklandiae (Radix Vladimiriae), nature and flavor: acrid, bitter, warm, have effect of promoting the circulation of QI to relieve pain, strengthening the spleen to promote digestion, weigh, food stagnation does not disappear, anorexia after being used for the treatment of breast gastral cavity distending pain, dysentery, and the real intestinal antidiarrheal of Radix Aucklandiae (roasted), for stomachache of having loose bowels;

Upper Cortex Cinnamomi, nature and flavor: extremely hot in nature, acrid in the mouth, sweet, there is effect of complement sun, warming the spleen and stomach, removing accumulated cold, promoting blood circulation, be used for the treatment of decline of the fire from the gate of life, cold extremities faint pulse, YANG-depletion collapse, stomachache are had loose bowels, colic of cold type renal mass, chills and pain of the waist and kness, amenorrhea and mass in the abdomen, carbuncle of yin nature, multiple abscess, empty sun are floating more, heat in the upper and cold in the lower;

Radix Glycyrrhizae Preparata, nature and flavor: sweet, flat, have effect of spleen reinforcing stomach function regulating, Yiqi and vein recovery, are used for the treatment of weakness of the spleen and stomach, fatigue and weakness, severe palpitation, irregularly intermittent and regularly intermittent pulse.

When taking, the herb liquid prepared is divided and within three days, takes, every day potion, the morning, noon and afternoon service once, dosage 200 milliliters/time, taking medicine before meal, and 25-28 agent of taking medicine, disease obtains recovery from illness.This medicine is that have compatibility science, the efficacy of a drug is powerful with common Chinese herbal medicine for raw material, hit pathogenesis, fully demonstrate soothing the liver reach strongly fragrant, the Therapeutic Principle that activating the spleen stimulates the menstrual flow.

Detailed description of the invention

Below embodiments of the present invention are described in detail

Amenorrhea is symptom common in gynaecopathia, can be caused by various different reason.Usually amenorrhea is divided into constitutional and Secondary cases two kinds.All persons that do not pass through yet over 18 years old are called primary amenorrhea; After menarche, in any time before normal menopause (gestation or age of sucking except), menstruation apolipsis is called secondary amenorrhea more than 6 months persons.Such differentiation is artificial to a great extent, because the Fundamentals causing former and secondary amenorrhea may be identical sometimes.But when providing the clue of the cause of disease and prognosis, this division is valuable, such as most birth defect, comprise the abnormal development of ovary or Seedling Le Shi tissue, the amenorrhea caused is put into primary amenorrhea, and secondary amenorrhea majority is caused by acquired disease, and more easily treats.

The present invention is exactly treatment for above-mentioned amenorrhea and a kind of Chinese herbal medicine formula proposed, and adopt herb liquid prepared by this formula, good drug efficacy, instant effect, toxic and side effects is little, effectively can treat amenorrhea.Below specific embodiment provided by the present invention is described in detail.

Embodiment 1:

The one-level Radix Astragali 10 grams selecting high-quality clean, RADIX CODONOPSIS PILOSULAE from Northwest of China 10 grams, bleaching art 5 grams, PORIA from Yunnan of China 10 grams, Radix Angelicae Sinensis 10 grams, Radix Paeoniae Alba 7 grams, Os Sepiae 7 grams, Radix Dipsaci 7 grams, Rhizoma Cyperi (processed) 5 grams, RADIX BUPLEURI SCORZONERIFOLII 3 grams, Radix Aucklandiae (Radix Vladimiriae) 3 grams, upper Cortex Cinnamomi 2 grams, Radix Glycyrrhizae Preparata 3 grams, stand-by after picking decontamination and dust respectively; Said medicine is put into about water purification soaks half an hour, with osmotic drug degree of being organized as, then again the clear liquor of soaked medicine and soak medicine is put into boiling machine in the lump, the cold boiled water injecting medicine 30mm carries out first time decoction 35 minutes, after leaching medicinal liquid, re-inject tepor boiled water and carry out second time decoction 30 minutes, merge the herb liquid 1800 milliliters being condensed into 50%, enter in refrigerator fresh-keeping for subsequent use after packed sealing.When taking, the herb liquid prepared is divided and within three days, takes, every day potion, the morning, noon and afternoon service once, dosage 200 milliliters/time, taking medicine before meal, and 25-28 agent of taking medicine, disease obtains recovery from illness.

Embodiment 2:

The one-level Radix Astragali 12 grams selecting high-quality clean, RADIX CODONOPSIS PILOSULAE from Northwest of China 12 grams, bleaching art 6 grams, PORIA from Yunnan of China 12 grams, Radix Angelicae Sinensis 12 grams, Radix Paeoniae Alba 8.5 grams, Os Sepiae 8.5 grams, Radix Dipsaci 8.5 grams, Rhizoma Cyperi (processed) 6 grams, RADIX BUPLEURI SCORZONERIFOLII 3.5 grams, Radix Aucklandiae (Radix Vladimiriae) 3.5 grams, upper Cortex Cinnamomi 2.5 grams, Radix Glycyrrhizae Preparata 3.5 grams, stand-by after picking decontamination and dust respectively; Said medicine is put into about water purification soaks half an hour, with osmotic drug degree of being organized as, then again the clear liquor of soaked medicine and soak medicine is put into boiling machine in the lump, the cold boiled water injecting medicine 30mm carries out first time decoction 35 minutes, after leaching medicinal liquid, re-inject tepor boiled water and carry out second time decoction 30 minutes, merge the herb liquid 1800 milliliters being condensed into 50%, enter in refrigerator fresh-keeping for subsequent use after packed sealing.When taking, the herb liquid prepared is divided and within three days, takes, every day potion, the morning, noon and afternoon service once, dosage 200 milliliters/time, taking medicine before meal, and 25-26 agent of taking medicine, disease obtains recovery from illness.

Embodiment 3:

The one-level Radix Astragali 10 grams selecting high-quality clean, RADIX CODONOPSIS PILOSULAE from Northwest of China 10 grams, bleaching art 5 grams, PORIA from Yunnan of China 10 grams, Radix Angelicae Sinensis 10 grams, Radix Paeoniae Alba 7 grams, Os Sepiae 7 grams, Radix Dipsaci 7 grams, Rhizoma Cyperi (processed) 5 grams, RADIX BUPLEURI SCORZONERIFOLII 3 grams, Radix Aucklandiae (Radix Vladimiriae) 3 grams, upper Cortex Cinnamomi 2 grams, Radix Glycyrrhizae Preparata 3 grams, stand-by after picking decontamination and dust respectively; Said medicine is put into about water purification soaks half an hour, with osmotic drug degree of being organized as, then again the clear liquor of soaked medicine and soak medicine is put into boiling machine in the lump, the cold boiled water injecting medicine 30mm carries out first time decoction 35 minutes, after leaching medicinal liquid, re-inject tepor boiled water and carry out second time decoction 30 minutes, merge the herb liquid 1800 milliliters being condensed into 50%, enter in refrigerator fresh-keeping for subsequent use after packed sealing.When taking, the herb liquid prepared is divided and within three days, takes, every day potion, the morning, noon and afternoon service once, dosage 200 milliliters/time, taking medicine before meal, and 25-27 agent of taking medicine, disease obtains recovery from illness.

The present invention is through the treatment to nearly one hundred routine patient, and therapeutic effect is remarkable, and toxic and side effects is little, and part allusion quotation shape case is as follows.

1, patient: history XX, female, 22 years old, address: Zhongjiang County, Sichuan Province

Illness symptom: by melancholy damaging the spleen and stomach before four months, menstruation does not come.It is abdomen severe pain in the afternoon less, and waist is bent and do not stretched, and both hands hug abdomen, and paroxysmal pain is shown effect, dirty white thing, and color of the lip is light, food poor appetite, emaciated physique, deep and stringy pulse and strength, and tongue glazing is shelled.

Treatment: throw top and control it, every day potion, the morning, noon and afternoon service once, and check after 12 doses of taking medicine, namely stomachache stop, and enter again medicine 8 doses, leucorrhea removes.Evident in efficacy, advise it according to Fang Xujin, appetite amelioration, in high spirits.

2, patient: Guo XX, female, 20 years old, address: Shuangliu County, Sichuan Province

Illness symptom: go to a doctor on August 10th, 2000.Readme: due to melancholy damaging the spleen and stomach before half a year, menstruation does not come.It early lacks abdomen pain after meal, and waist is bent and do not stretched, and both hands of bending over hug abdomen, and unbearably, dirty white thing, color of the lip is light, and food of receiving is not good, emaciated physique for paroxysmal pain.

Treatment: throw top and control it, every day potion, the morning, noon and afternoon service once, and check after 10 doses of taking medicine, namely stomachache stop, and enters again medicine 10 doses, and leucorrhea disappears.Advise its Fang Xujin like this again, appetite amelioration, in high spirits, disease obtains recovery from illness.

3, patient: woods XX, female, 18 years old, address: Xinjin County, Sichuan Province

Illness symptom: readme, before two months, causes amenorrhea because of melancholy damaging the spleen and stomach, the bimester that menstruation not coming.And then few abdomen pain, waist is bent and is not stretched, and paroxysmal pain obtains both hands and hugs abdomen, dirty white thing, and color of the lip is light, does not think to receive food, lean body mass.

Treatment: throw top and control it, every day potion, the morning, noon and afternoon service once, and check after 13 doses of taking medicine, stomachache disappears, and enter again medicine 10 doses, leucorrhea loses.Advising it to consolidate continues into several doses again, and appetite recovers normal, and all diseases are all removed and heal.

Claims (3)

1. treat an endo-medicine for amenorrhea, it is characterized in that, each component of described medicine and mass parts thereof are than as follows:

Radix Astragali (wine stir-fry) 1-3 part;

RADIX CODONOPSIS PILOSULAE from Northwest of China 1-3 part;

Bleaching art 1-3 part;

PORIA from Yunnan of China 1-3 part;

Radix Angelicae Sinensis 1-3 part;

Radix Paeoniae Alba (wine stir-fry) 1-3 part;

Os Sepiae 1-3 part;

Radix Dipsaci 1-3 part;

Rhizoma Cyperi (processed) 1-3 part;

RADIX BUPLEURI SCORZONERIFOLII 1-3 part;

Radix Aucklandiae (Radix Vladimiriae) 1-3 part;

Upper Cortex Cinnamomi 1-3 part;

Radix Glycyrrhizae Preparata 1-3 part.

2. the endo-medicine for the treatment of amenorrhea according to claim 1, is characterized in that, each component of described medicine and mass parts thereof are than as follows:

Radix Astragali (wine stir-fry) 1 part;

RADIX CODONOPSIS PILOSULAE from Northwest of China 1 part;

Bleaching art 1 part;

PORIA from Yunnan of China 1 part;

Radix Angelicae Sinensis 1 part;

Radix Paeoniae Alba (wine stir-fry) 1 part;

Os Sepiae 1 part;

Radix Dipsaci 1 part;

Rhizoma Cyperi (processed) 1 part;

RADIX BUPLEURI SCORZONERIFOLII 1 part;

Radix Aucklandiae (Radix Vladimiriae) 1 part;

Upper Cortex Cinnamomi 1 part;

Radix Glycyrrhizae Preparata 1 part.

3. endo-medicine of the treatment amenorrhea described in a claim 1 or 2 and preparation method thereof, is characterized in that, described method comprises the steps:

A, according to mass parts than selecting the clean one-level Radix Astragali (wine stir-fry) of high-quality, RADIX CODONOPSIS PILOSULAE from Northwest of China, bleaching art, PORIA from Yunnan of China, Radix Angelicae Sinensis, Radix Paeoniae Alba (wine stir-fry), Os Sepiae, Radix Dipsaci, Rhizoma Cyperi (processed), RADIX BUPLEURI SCORZONERIFOLII, Radix Aucklandiae (Radix Vladimiriae), upper Cortex Cinnamomi, Radix Glycyrrhizae Preparata, stand-by after picking decontamination and dust respectively;

B, said medicine put into about water purification soaks half an hour, with osmotic drug degree of being organized as, then again the clear liquor of soaked medicine and soak medicine is put into boiling machine in the lump, the cold boiled water injecting medicine 30mm carries out first time decoction 35 minutes, after leaching medicinal liquid, re-inject tepor boiled water and carry out second time decoction 30 minutes, merge the herb liquid 1800 milliliters being condensed into 50%, enter in refrigerator fresh-keeping for subsequent use after packed sealing.