CN104758571A - Preparation method for capsules for treating gastroptosis - Google Patents
Preparation method for capsules for treating gastroptosis Download PDFInfo
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- CN104758571A CN104758571A CN201510208915.6A CN201510208915A CN104758571A CN 104758571 A CN104758571 A CN 104758571A CN 201510208915 A CN201510208915 A CN 201510208915A CN 104758571 A CN104758571 A CN 104758571A
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Abstract
The invention discloses a preparation method for capsules for treating gastroptosis in order to treat gastroptosis. The preparation method includes the steps that (1) volatile oil of oroxylum indicum vent, Cipadessa baccifera, prinsepia uniflora batal, fragrant sarcococca herb and north chinese fritillary rough powder is extracted for use; (2) water extraction by alcohol sedimentation is carried out on snail shells, parmelia tinctourium, solanum lyratum thumb, eucheuma, timonius arboreus, garbanzo and herb residue water obtained in the first step, supernate is concentrated, dried and crushed, and then dry extract powder is obtained; (3) the volatile oil is sprayed into the dry extract powder, mixed evenly, crushed, screened through a 60-mesh screen and finally injected into capsules. The clinical experiment shows that the capsules for treating gastroptosis have the advantages of being good in treatment effect and high in safety, and are worthy of clinical application and popularization.
Description
Technical field
The present invention relates to the field of Chinese medicines, be specifically related to a kind of capsule preparation method thereof for the treatment of gastroptosis.
Background technology
Gastroptosis (gastroptosis) is because diaphram hangs power deficiency, supports internal organs laxity of ligament, or intra-abdominal pressure reduces, and abdominal muscle relaxes, and when causing standing, greater gastric curvature arrives at pelvic cavity, and lesser gastric curvature camber line minimum point drops to below crista iliaca on line.Its cause of disease is varied, all factors that diaphram position can be caused to decline, and as diaphragm activity power reduces, abdominal pressure reduces, and contraction of abdominal muscle power weakens, and gastrophrenic ligament, gastrohepatic ligaments, gastrosplenic ligament, gastrocolic ligament are too lax, all can cause sagging.
At present, for the treatment of gastroptosis, specific medicament is not had for doctor trained in Western medicine, general with reference to chronic gastritis treatment, and the slow person of abdominal distention, gastric emptying, motilium or metoclopramide can be supplied.And the traditional Chinese medical science thinks that gastroptosis main because eating and drinking without temperance, excessively overstrain, feelings will are hindered and the reason such as innate deficiency causes thin and weak body to form.Its disease is deficiency in origin and excess in superficiality, is weakness of the spleen and stomach, sinking of QI of middle-JIAO at this; Being designated as dyspepsia, drink stops, the stagnation of QI and blood stasis.The side of sending mostly is BUZHONG YIQI TANG, or linggui zhugan decoction closes Small Pinelliae Decoction invigorating the spleen and regulating the stomach.But said medicine spininess is to symptom, short term efficacy is good, does not have clear improvement, cause relapse rate in a year high for recovery diaphram tension force.
Summary of the invention
Technical assignment of the present invention is for above the deficiencies in the prior art, provides a kind of curative effect certainly and the capsule preparation method thereof of the little treatment gastroptosis of side effect.
The technical scheme that the present invention solves its technical problem is: a kind of pharmaceutical composition reducing gastroptosis relapse rate, it is characterized in that being prepared from by the crude drug of following weight proportion: Semen Oroxyli 10 ~ 20 parts, Fructus Chaenomelis 3 ~ 12 parts, Sarcococca ruscifolia Stapf 12 ~ 20 parts, Rui core 12 ~ 20 parts, flat shellfish 12 ~ 20 parts, Herba Solani Lyrati 1 ~ 5 part, Crusta Limax 1 ~ 2 part, alizarin 3 ~ 12 parts of sea, Semen Ciceris Arietini 10 ~ 25 parts, Eucheuma muricatum (Gmel.) Web.Van Bos. 3 ~ 12 parts, sub-sieve Chinese toon 1 ~ 2 part, Parmelia saxatilis Ach. 12 ~ 20 parts.
Chinese medicine of the present invention can be prepared from by following method:
(1) Semen Oroxyli, sub-sieve Chinese toon, Rui core, Sarcococca ruscifolia Stapf, flat shellfish coarse powder are extracted volatile oil with vapor distillation respectively, and mixing for standby use after collecting, medicinal residues are continued to employ;
(2) gained medicinal residues mixing in Crusta Limax, Parmelia saxatilis Ach., Herba Solani Lyrati, Eucheuma muricatum (Gmel.) Web.Van Bos., Hai Qian, Semen Ciceris Arietini and step 1 is added 8 times of water yields, decoct with water 2 times, each 1 hour, collecting decoction, leave standstill; Then in decocting liquid, add the ethanol of 95% of 3 ~ 4 times of medicinal liquids, leave standstill 4h, get supernatant, be evaporated to 1.30 ~ 1.36(60 DEG C), drying under reduced pressure (60 DEG C, 0.09MPa), is ground into dry extract;
(3) gained volatile oil in step 1 is sprayed in step 2 gained dry extract mix, pulverize, cross 60 mesh sieves, encapsulated and get final product.
Wherein said: Semen Oroxyli is the dry mature seed of Bignoniaceae plant oroxylum indicum Oroxylum indicum (L.) Vent..Nature and flavor are sweet, cool.Return lung, liver, stomach warp.Function cures mainly: removing heat from the lung and relieving sorethroat, dispersing the stagnated liver-QI for regulating the stomach.For cough due to lung-heat, sore throat, hoarseness, stomachache due to hyperactive liver-QI attacking the stomach.
Fructus Chaenomelis is the dry almost ripe fruit of rosaceous plant chaenomeles lagenaria Chaenomeles speciosa (Sweet) Nakai.Nature and flavor acid, temperature.Return liver, spleen channel.Function cures mainly: suppressing the hyperactive liver relaxing muscles and tendons, stomach function regulating removing dampness.For arthralgia chiefly caused by damp pathogen contracture, the heavy pain of waist knee joint acid, convulsion of vomiting and diarrhoea, beriberi edema.
Sarcococca ruscifolia Stapf is Buxaceae Sarcococca plant open country fan flower Sarcococca ruscifolia Stapf root.Nature and flavor are pungent, bitter, flat.Merit can regulating QI to relieve pain, dispelling, collateral-activating.
Rui core is rosaceous plant Rui core Prinsepia uniflora Batal. or the drying and ripening pit of tingia Folium Prinsepiae Utilis Prinsepia uniflora Batal. var. serrata Rehd..Nature and flavor are sweet, are slightly cold.Return Liver Channel.Function cures mainly: nourishing the liver to improve visual acuity, wind-dispelling heat-dissipating.For conjunctival congestion and swelling pain, red and fester on the palpebral margin, the dark photophobia of order.
Flat shellfish is the dry bulb of liliaceous plant Bulbus Fritillariae Ussuriensis Fritillaria ussuriensis Maxim..Nature and flavor are bitter, sweet, are slightly cold.Return lung, heart channel.Function cures mainly: clearing heat and moistening lung, preventing phlegm from forming and stopping coughing.For lung-heat type cough, the few expectorant of dry cough, deficiency of YIN chronic cough, sputum with blood.
Herba Solani Lyrati is the herb of plant of Solanaceae Herba Solani Lyrati Solanum lyratum Thunb..Sweet in the mouth; Bitter; Cold in nature.Return liver; Gallbladder; Kidney channel.Merit can clearing away heat-damp and promoting diuresis; Removing toxic substances and promoting subsidence of swelling.
Crusta Limax is the shell of Bradybaenidae animal Bradybaena similaris Ferussac Bradybaena similaris and magnificent Limax Cataica fasciola and equal sibling species thereof.Merit can QI invigorating.
Hai Qian is Sargassaceae plant Alga Sgrgassi Enerves Sargassum enerve C.Ag., Sargassum henslowianum Sargassum henslowianum C.Ag., sargassum thunbergii Sargassum thunbergii(Mert.) O.Kuntze or Sargassum phyllocystum Tseng et Lu,Sargassum horneri (Turn.) C. Ag. (Fucus horneri (Turn.)C.Ag.,Spongocarpus horneri Kutz.) argassum horneri(Turn.) frond of C. Ag.Nature and flavor are salty; Cold.Return liver; Stomach; Kidney channel.Merit can hard masses softening and resolving; Removing heat-phlegm.
Semen Ciceris Arietini is the seed of leguminous plant chickpea Cicer arietinum L.Nature and flavor are sweet; Flat; Nontoxic.Return lung; Stomach warp.Merit can heat-clearing and toxic substances removing.
Eucheuma muricatum (Gmel.) Web.Van Bos. is Hong Ling dish section plant Eucheuma muricatum (Gmel.) Web.Van Bos. and Margarita Eucheuma muricatum (Gmel.) Web.Van Bos. Eucheuma muricatum(Gmel.) Web.van Bos.; The frond of Eucheuma okamurai Yamada.Sour in the mouth is sweet, tepor, nontoxic.Merit can the therapeutic method to keep the adverse QI flowing downwards, helps digestion.
Parmelia saxatilis Ach., clock emulsion Stakactite dropstone falls apart and spatters as flower person.Nature and flavor are sweet; Temperature; Nontoxic.Function cures mainly: the kidney warming; Bone strengthening; Supporing yang.Main muscles and bones flaccidity is soft; Waist foot cold type of pain; Impotence and premature ejaculation.
Sub-sieve Chinese toon, is Meliaceae sub-sieve Chinese toon Cipadessa baccifera Miq., is used as medicine with root, leaf.Nature and flavor are bitter, cool.Function cures mainly: dispelling wind to relieve the exterior syndrome, preventing the attack (or recurrence) of malaria.Cure mainly malaria.
In prior art, think that gastroptosis main because eating and drinking without temperance, excessively overstrain, feelings will are hindered and the reason such as innate deficiency causes thin and weak body to form more.Its disease is deficiency in origin and excess in superficiality, is weakness of the spleen and stomach, sinking of QI of middle-JIAO at this; Being designated as dyspepsia, drink stops, the stagnation of QI and blood stasis.The side of sending mostly is BUZHONG YIQI TANG, or linggui zhugan decoction closes Small Pinelliae Decoction invigorating the spleen and regulating the stomach.But said medicine spininess is to symptom, short term efficacy is good, does not have clear improvement, cause relapse rate in a year high for recovery diaphram tension force.
But modern Pathological findings shows, the main pathological factor that diaphram tension force declines, energy difference is gastroptosis, and the symptom that stomach shows is declining due to diaphram position, causes stomach tractive to produce, namely mark.In prior art, mainly consider invigorating the spleen and regulating the stomach, can alleviate stomach symptom in a short time, but diaphram tension force does not improve, therefore take merely the rule for the treatment of of invigorating the spleen and replenishing QI, relapse rate is high.
And inventor's clinical experience gained for many years, improve fascia and elastic fibers in time, thus increase diaphram tension force and mobility, reduce the probability of the bad initiation gastroptosis that bounces back.
Compared with prior art, the present invention has following characteristics:
1, prescription with Semen Oroxyli, Fructus Chaenomelis for monarch: Semen Oroxyli used in amounts is large, and Semen Oroxyli enters conception vessel, " conception vessel person, arises under middle pole, above suprapubic hair margin, follow in abdomen, shangguan unit, and to throat, upper chin or cheek, follows face, enters order ".Semen Oroxyli is gas medicine, floats gently, and heavy dose of use, can draw all medicines up.Semen Oroxyli is cool in nature, and the Another reason matched with Fructus Chaenomelis is that Fructus Chaenomelis is warm in nature, can in and the cold and cool inflexible knot of Semen Oroxyli; And sour and sweet drugs can transforme into YIN, can maintenance diaphragm space between skin and muscles;
2, with Sarcococca ruscifolia Stapf, Rui core for minister, Sarcococca ruscifolia Stapf, Rui core walk edema caused by disorder of QI, enter conception vessel, have tying-in top object function, so consumption is greater than at ordinary times; And Semen Oroxyli, Sarcococca ruscifolia Stapf pungent and sweet drugs can invigorate YANG, burnt in solid protection;
3, with Semen Ciceris Arietini, flat shellfish, Herba Solani Lyrati, Hai Qian, Crusta Limax for assistant, dampness removing, invigorate blood circulation, moisturize, removing toxic substances and promoting subsidence of swelling, QI invigorating, promote that cell migration alleviates the discomfort because gastric mucosa tractive causes, Herba Solani Lyrati is too cold and cool, and therefore consumption should be little;
4, take Eucheuma muricatum (Gmel.) Web.Van Bos. as using corrigent, all medicines all rise, and getting the Eucheuma muricatum (Gmel.) Web.Van Bos. therapeutic method to keep the adverse QI flowing downwards is simply using corrigent, prevent from rising faling apart too getting angry, therefore Eucheuma muricatum (Gmel.) Web.Van Bos. dosage is less than normal
5, be that assistant helps with Parmelia saxatilis Ach., warming YANG activating QI, makes capable active of the gas of raw liter;
6, help for helping with sub-sieve Chinese toon, sub-sieve Chinese toon medicine is walked to disperse, and row is outside flesh side film, and low dose adds promotion gastric mucosa local absorption.
Detailed description of the invention
Below in conjunction with practical situation, the specific embodiment of the present invention is elaborated.
Embodiment 1, crude drug weight proportion: Semen Oroxyli 20g, Fructus Chaenomelis 12g, Sarcococca ruscifolia Stapf 15g, Rui core 15g, flat shellfish 15g, Herba Solani Lyrati 2g, Crusta Limax 1g, extra large alizarin 12g, Semen Ciceris Arietini 20g, Eucheuma muricatum (Gmel.) Web.Van Bos. 12g, sub-sieve Chinese toon 1g, Parmelia saxatilis Ach. 15g.
The preparation method of embodiment 1 is: Semen Oroxyli, Rui core, Fructus Chaenomelis, Sarcococca ruscifolia Stapf, Eucheuma muricatum (Gmel.) Web.Van Bos., Crusta Limax, sub-sieve Chinese toon, Parmelia saxatilis Ach., flat shellfish, Herba Solani Lyrati, Hai Qian, Semen Ciceris Arietini mixing and water adding are decocted, filtrate is got after 30 minutes, medicinal residues add water continue decoction get filtrate after 20 minutes, twice filtrate merges, and a point morning and evening takes.
Embodiment 2, crude drug weight proportion: Semen Oroxyli 10 parts, Fructus Chaenomelis 3 parts, Sarcococca ruscifolia Stapf 12 parts, Rui core 12 parts, flat shellfish 12 parts, Herba Solani Lyrati 1 part, Crusta Limax 1 part, alizarin 3 parts of sea, Semen Ciceris Arietini 10 parts, Eucheuma muricatum (Gmel.) Web.Van Bos. 3 parts, sub-sieve Chinese toon 1 part, Parmelia saxatilis Ach. 12 parts.
Embodiment 3, crude drug weight proportion: Semen Oroxyli 20 parts, Fructus Chaenomelis 10 parts, Sarcococca ruscifolia Stapf 15 parts, Rui core 15 parts, flat shellfish 15 parts, Herba Solani Lyrati 2 parts, Crusta Limax 1 part, alizarin 12 parts of sea, Semen Ciceris Arietini 20 parts, Eucheuma muricatum (Gmel.) Web.Van Bos. 12 parts, sub-sieve Chinese toon 1 part, Parmelia saxatilis Ach. 15 parts.
Embodiment 4, crude drug weight proportion: Semen Oroxyli 15 parts, Fructus Chaenomelis 12 parts, Sarcococca ruscifolia Stapf 20 parts, Rui core 20 parts, flat shellfish 20 parts, Herba Solani Lyrati 5 parts, Crusta Limax 2 parts, alizarin 9 parts of sea, Semen Ciceris Arietini 25 parts, Eucheuma muricatum (Gmel.) Web.Van Bos. 9 parts, sub-sieve Chinese toon 2 parts, Parmelia saxatilis Ach. 20 parts.
The Chinese medicine of embodiment 2 ~ 4 can be prepared from by following method:
(1) Semen Oroxyli, sub-sieve Chinese toon, Rui core, Sarcococca ruscifolia Stapf, flat shellfish coarse powder are extracted volatile oil with vapor distillation respectively, and mixing for standby use after collecting, medicinal residues are continued to employ;
(2) gained medicinal residues mixing in Crusta Limax, Parmelia saxatilis Ach., Herba Solani Lyrati, Eucheuma muricatum (Gmel.) Web.Van Bos., Hai Qian, Semen Ciceris Arietini and step 1 is added 8 times of water yields, decoct with water 2 times, each 1 hour, collecting decoction, leave standstill; Then in decocting liquid, add the ethanol of 95% of 3 ~ 4 times of medicinal liquids, leave standstill 4h, get supernatant, be evaporated to 1.30 ~ 1.36(60 DEG C), drying under reduced pressure (60 DEG C, 0.09MPa), is ground into dry extract;
(3) gained volatile oil in step 1 is sprayed in step 2 gained dry extract mix, pulverize, cross 60 mesh sieves, encapsulated and get final product.
Capsule dosage can be equivalent to crude drug 22g for medicine in each capsule, each serving with 3 pieces, and every day 2 times.
The efficient combination of said medicine, coordinates mutually, effectively reach the object reducing gastroptosis incidence rate, and side effect is less.The above results is clinical data sufficient proof, and interrelated data is as follows.
1 object and method.
1.1.1 case selection: in January, 2012 ~ 2014 severe gastroptosis patient 92 example in x-ray is made a definite diagnosis in year January, wherein the age is 22 ~ 59(39.3 ± 12.9) year; Female 48 example, man 44 example; The course of disease 1 ~ 10 year.Be divided into matched group 32 example, decoction group 29 example and Capsules group 31 example.Compare in sex, age, course of disease situation before three groups of patient treatments, no significant difference (P>0.05), has comparability.
1.1.2 diagnostic criteria: when standing, it is slight that stomach x-ray barivm meal fluoroscopy (screem) lesser gastric curvature camber line minimum point is down to below interiliac line 1 ~ 5cm, and 6 ~ 10cm is moderate, and more than 11cm is severe.
1.2 method.
1.2.1 Therapeutic Method: matched group BUZHONG YIQI TANG (Radix Astragali 15g, Radix Codonopsis 15g, Rhizoma Atractylodis Macrocephalae 10g, Radix Glycyrrhizae Preparata 15g, Radix Angelicae Sinensis 10g, Pericarpium Citri Reticulatae 6g, Rhizoma Cimicifugae 6g, Radix Bupleuri 12g) decocting is oral.Decoction group is oral with gained decoct in the embodiment of the present invention 1.Capsules group is with gained capsule oral in the embodiment of the present invention 3.Three groups are one day twice, treat 4w altogether.
1.2.2 efficacy assessment standard is cured: subjective symptoms disappears, and when standing, stomach x-ray barivm meal fluoroscopy (screem) lesser gastric curvature camber line minimum point is the above person of interiliac line; Effective: subjective symptoms obviously alleviates, lesser gastric curvature camber line minimum point does not reach interiliac line but the above person of rising 6cm; Take a turn for the better: lesser gastric curvature camber line minimum point does not reach interiliac line but the 2 ~ 5cm person that rises; Invalid: without changer before and after treatment.
1.2.3 statistical analysis: SPSS 16.0 carries out statistical analysis.Measurement data t checks, enumeration data χ
2inspection.
2 results.
2.1 3 groups of treatments, 4 weeks rear comparitive study: see the following form,
| Group | Number of cases | Cure | Effective | Take a turn for the better | Invalid | Effective percentage | Cure rate |
| Matched group | 32 | 10 | 8 | 10 | 4 | 87.50% | 31.25% |
| Decoction group | 29 | 17 | 5 | 3 | 4 | 86.21% | 65.52% |
| Capsules group | 31 | 17 | 7 | 4 | 3 | 90.32% | 64.52% |
Wherein, three groups of total effective rate difference are little, but the cure rate of decoction group and Capsules group is but apparently higher than matched group (χ
2=4.62, P<0.05; χ
2=4.59, P<0.05).
2.2 3 groups of recurrences in 1 year: treat effective case with examining observation, in matched group, decoction group, Capsules group 1 year, relapse rate is respectively 46.43%(13/28), 20.0%(5/25), 14.29%(4/28).Three compares, and decoction group, Capsules group relapse rate are starkly lower than matched group (χ
2=4.11, P<0.05; χ
2=6.84, P<0.01).
2.3 medicine related reactions incidence rates compare: three groups are and occur medicine related reactions, and before and after treatment, significant change does not occur for hepatic and renal function, hematuria routine.
3. conclusion.
This result of study shows, decoction group of the present invention and Capsules group is used can effectively to alleviate gastroptosis symptom, cure rate and in 1 year relapse rate and BUZHONG YIQI TANG all with obvious significant difference, illustrate the present invention have in treatment gastroptosis effect certainly, advantage that relapse rate is low.
Claims (1)
1. treat a capsule preparation method thereof for gastroptosis, it is characterized in that, crude drug is Semen Oroxyli, Rui core, Fructus Chaenomelis, Sarcococca ruscifolia Stapf, Eucheuma muricatum (Gmel.) Web.Van Bos., Crusta Limax, sub-sieve Chinese toon, Parmelia saxatilis Ach., flat shellfish, Herba Solani Lyrati, Hai Qian, Semen Ciceris Arietini, and preparation method is made up of following steps:
(1) Semen Oroxyli, sub-sieve Chinese toon, Rui core, Sarcococca ruscifolia Stapf, flat shellfish coarse powder are extracted volatile oil with vapor distillation respectively, and mixing for standby use after collecting, medicinal residues are continued to employ;
(2) gained medicinal residues mixing in Crusta Limax, Parmelia saxatilis Ach., Herba Solani Lyrati, Eucheuma muricatum (Gmel.) Web.Van Bos., Hai Qian, Semen Ciceris Arietini and step 1 is added 8 times of water yields, decoct with water 2 times, each 1 hour, collecting decoction, leave standstill; Then in decocting liquid, add the ethanol of 95% of 3 ~ 4 times of medicinal liquids, leave standstill 4h, get supernatant, be evaporated to 1.30 ~ 1.36(60 DEG C), drying under reduced pressure (60 DEG C, 0.09MPa), is ground into dry extract;
(3) gained volatile oil in step 1 is sprayed in step 2 gained dry extract mix, pulverize, cross 60 mesh sieves, encapsulated and get final product.
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|---|---|---|---|---|
| CN102727779A (en) * | 2012-07-04 | 2012-10-17 | 王海霞 | Pharmaceutical composition for treating ovarian cysts and preparation method thereof |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102727779A (en) * | 2012-07-04 | 2012-10-17 | 王海霞 | Pharmaceutical composition for treating ovarian cysts and preparation method thereof |
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| Title |
|---|
| 朱应来: "胃下垂治验四则", 《实用中医内科杂志》 * |
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