Summary of the invention
The theory of " equilibrium between yin and yang healthy " in theory of Chinese medical science, for the medical treatment of sub-health state has indicated direction.
The traditional Chinese medical science thinks that human body take the internal organs that negative and positive are representative, and the full and orthofunction of essence, gas, blood, body fluid is optimum state, in one word: " YIN and YANG in a relative equilibrium ", completely healthy.Once departing from appears in this poised state between negative and positive, may be summarized to be all cards such as the deficiency of YIN, yang deficiency, the deficiency of vital energy, phlegm-damp, human body just there will be the sub-health state of various trend pathology.
The inventor, through research and clinical experiment repeatedly, has found the more satisfactory sub-health status that improves finally, promotes immunologic function, stops the pathogenetic Chinese medicine preparation of disease.Face card and accomplish " sincerely examine the place of negative and positive and adjust it, to put down, schedule to last " (< < Plain Questions the most pure virginity will be discussed greatly > >), receiving better effects treating aspect subhealth state.
Medicament selection 22 taste Chinese medicines of the present invention, under Chinese and western medicine theory instructs, carry out combination and compatibility, make these drug regimen compatibilities produce the incomparable effect of single medicinal material curative effect, improve health status, prophylactic generation thereby effectively promote immunologic function.
The present invention is made by the crude drug of following weight portion:
Radix Ginseng 20-40 Radix Angelicae Sinensis 20-25 Rhizoma Polygonati 10-30 fresh ginger 10-15 Fructus Jujubae 15-25 Fructus Lycii 5-10 Radix Paeoniae Alba 15-30 Bulbus Lilii 20-30 Flos Spatholirionis longifolii 5-10 Radix Bupleuri 20-40 Rhizoma Polygonati Odorati 10-20 Rhizoma Atractylodis 10-25 Radix Astragali 30-35 Semen Benincasae 5-15 Fructus Corni 5-10 Fructus Schisandrae Chinensis 20-25 Arillus Longan 10-15 Fructus Crataegi 20-30 Cortex Moutan 15-25 Cortex Eucommiae 5-10 5-15 Radix Ophiopogonis Radix Platycodonis 10-20.
Preferably, the present invention is made by the crude drug of following weight portion:
Radix Ginseng 25-30 Radix Angelicae Sinensis 20-25 Rhizoma Polygonati 20-30 fresh ginger 12-15 Fructus Jujubae 18-20 Fructus Lycii 5-10 Radix Paeoniae Alba 15-25 Bulbus Lilii 20-25 Flos Spatholirionis longifolii 5-10 Radix Bupleuri 30-40 Rhizoma Polygonati Odorati 15-20 Rhizoma Atractylodis 15-20 Radix Astragali 30-35 Semen Benincasae 10-15 Fructus Corni 5-10 Fructus Schisandrae Chinensis 20-25 Arillus Longan 10-15 Fructus Crataegi 20-25 Cortex Moutan 15-20 Cortex Eucommiae 5-10 10-15 Radix Ophiopogonis Radix Platycodonis 15-20.
Most preferably, the present invention is made by the crude drug of following weight portion:
Radix Ginseng 30 Radix Angelicae Sinensis 20 Rhizoma Polygonati 25 fresh ginger 10 Fructus Jujubae 25 Fructus Lycii 10 Radix Paeoniae Alba 20 Bulbus Lilii 25 Flos Spatholirionis longifolii 5 Radix Bupleuri 20 Rhizoma Polygonati Odorati 15 Rhizoma Atractylodis 15 Radix Astragali 30 Semen Benincasae 10 Fructus Corni 10 Fructus Schisandrae Chinensis 20 Arillus Longan 10 Fructus Crataegi 20 Cortex Moutan 20 Cortex Eucommiae Radix Platycodoniss 20 10 Radix Ophiopogonis 15.
The present invention takes according to said medicine share proportioning, mixes, and pulverizes, and sieves, and according to a conventional method, water is general is ball, is prepared as the watered pill of Semen phaseoli radiati grain size.Or make electuary, honeyed pill etc., make arbitrary conventional peroral dosage form and all can.
Radix Ginseng, property is flat, sweet in the mouth, micro-hardship, tepor.Return spleen, lung meridian, heart channel.Strongly invigorating primordial QI, multiple arteries and veins is admittedly de-, invigorating the spleen to benefit the lung, promoting the production of body fluid to quench thirst, the Fructus Alpiniae Oxyphyllae of calming the nerves.Cure mainly that impairment caused by overstrain is deficient, lack of appetite, asthenia, regurgitation are told food, stool lingering diarrhea, empty cough with asthma are short, spontaneous perspiration sudden collapse, palpitation with fear, forgetful, dizzy, headache, sexual impotence, frequent micturition, quench one's thirst, woman uterine bleeding, children's's intermittent infantile convulsion and prolonged deficiency multiple, the disease of all qi-blood-body fluid deficiencies.Through modern study, prove that it has following pharmacological action: 1, the regulating action to central nervous system; 2, improve the adaptability of body; 3, regulate the effect of cardiovascular system; 4, Antishock function; 5, strengthen liver function effect; 6, the regulating action of Endocrine system; 7, the regulating action to substance metabolism.
Radix Angelicae Sinensis, sweet in the mouth is pungent, enters conscience spleen channel, function: benefiting blood and regulating blood circulation pain relieving, loosening bowel to relieve constipation, cures mainly: nutrient blood is weak, constipation, multiple pain disease; Modern pharmacological research: promote hemoglobin and erythropoiesis, protection hepatic injury, promotes liver cell regeneration; recover liver function, antithrombotic, blood fat reducing; prevent and treat arteriosclerosis, resist myocardial ischemia, anoxia; expansion external perihaemal canal, blood pressure lowering strengthens cell and humoral immune function, has spasmolytic; calm; antiinflammatory, anti-hypoxia Antiradiation injury, suppresses the function of some tumor growth.
Rhizoma Polygonati, begins to carry Wei Jin < < Mingyi Bielu > >, and another name " celestial being's surplus grain ", " JIUMINGCAO " etc. claim again Caput Gallus domesticus ginseng.Property sweet, taste is flat.Return lung, spleen, kidney channel.Function nourishing kidney lung moistening, invigorating the spleen and replenishing QI.Be usually used in lung-dryness syndrome due to deficiency of YIN, the few expectorant of dry cough and deficiency of YIN phthisical cough, the dizziness due to deficiency of kidney-essence, soreness of the waist and knees, early whitening of beard and hair, quenches one's thirst etc.< < Compendium of Materia Medica > > claims: " Rhizoma Polygonati is mended all void; replenishing essence marrow; flat filling blood and moistening, and Rhizoma Polygonati is subject to penta pure gas, therefore be the victory product in yellow palace; the mother of native person's all things on earth; female and support, and extreme misery help, and wooden gold is joined; and all heresies are from going, and all kinds of diseases and ailments are life! " < < Sheng Nong's herbal classic > > carries: " Rhizoma Polygonati alleviating distention in middle-JIAO QI invigorating, adjusts the five internal organs good, muscle sufficiency, bone marrow is strong, and its power multiplication is not old for many years, turn white more black, dedentition is more raw.
Fresh ginger, is the fresh rhizome of zingiber, acrid in the mouth lung meridian warm in nature, expelling cold and relieving exterior syndrome, preventing phlegm from forming and stopping coughing, control anemofrigid cold, phlegm retention is breathed with cough.Modern pharmacological research: calm, antipyretic, antiinflammatory, anti-various pathogens and hepatitis B virus, cough-relieving, blood fat reducing, excited maincenter, short activity in vivo thing discharge.
Fructus Jujubae, sweet, temperature, returns spleen, stomach warp; Cure mainly: invigorating the spleen and replenishing QI, nourishing blood to tranquillize the mind.For insufficiency of the spleen lack of appetite, weak loose stool, woman hysteria.
Fructus Lycii, sweet, flat, enter liver, stomach two warps, doublely enter lung meridian; Cure mainly: the kidney invigorating and essence nourishing, nourishing the liver to improve visual acuity, blood-enriching tranquillizing, promoting the production of body fluid to quench thirst, nourishing the lung to arrest cough.Cure mainly: control apoplexy dizzy, asthenia, is allly shown in blood disorder, cough blood, flaccidity, faint, contraction, the miasma that disappears, hinder dry, seminal emission, reddish and whitish turbid urine, beriberi, the arthroncus of knee.
The Radix Paeoniae Alba, sweet-bitter flavor is slightly cold, and enters Liver Channel, function: easing the affected liver to relieve pain, the yin fluid astringing that nourishes blood, suppressing liver-YANG, cures mainly: distending pain in the chest and hypochondrium, spontaneous sweating, dizziness, dizzy etc.; Modern pharmacological research: regulate body's immunity, central nervous system is had to calmness, analgesia, convulsion, antipyretic cooling; resisting oxygen lack, antiplatelet, suppresses thrombosis; coronary artery dilator and peripheral blood vessel, reduce blood pressure, and resists myocardial ischemia; control digestive system and ulcer, protection hepatic injury, antibacterial; antiviral, blood sugar lowering, removes free radical; anti-hypoxia, antioxidation strengthens learning memory.
Bulbus Lilii, sweet in the mouth, cold nature, enter the heart, lung meridian.Function: nourishing YIN and moistening the lung, clearing away heart-fire for tranquillization.For deficiency of YIN chronic cough, sputum mixed with blood, fidgets due to deficiency palpitation with fear, insomnia and dreamful sleep, absentminded.There is nourishing YIN and moistening the lung cough-relieving effect.Pharmacological action has: 1, Antitussive and Expectorant Effect; 2, sedation; 3, nourishing YIN and moistening the lung effect; 4, strong effect; 5, antitumaous effect.
Flos Spatholirionis longifolii is puckery, cool.Effect is QI and blood regulating, pain relieving, and treatment menoxenia, nervous headache and constipation, have toxin expelling effect.
Radix Bupleuri, bitter in the mouth is pungent cold, enters liver, gallbladder, percardium warp, function, reducing fever by reconciliation, dispersing the stagnated live-QI to relieve the stagnation of QI, elevate a turnable ladder yang-energy, cures mainly easy catching a cold heating, stagnation of liver-QI costalgia, dizzy irritability, sinking of QI of middle-JIAO; Modern pharmacological research: antipyretic and anti-inflammatory, reduce plasma cholesterol, calmness, analgesia, antitussive, improves immunity of organisms, anti-liver injury, function of gallbladder promoting reduces transaminase, anti-fatty liver, excited gastrointestinal smooth muscle, antiulcer, regulates uterus function.
Rhizoma Polygonati Odorati, nourishing YIN and moistening the lung, nourishing the stomach to promote the production of body fluid.Main cough caused by dryness chronic cough, the dry throat and mouth of the cloudy liquid consumption of calentura wound, interior-heat is quenched one's thirst, dizzy dizzy, muscle arteries and veins spasm and pain etc.< < Sheng Nong's herbal classic > > carries that " main apoplexy sudden high fever, can not shake, and falls muscle knot meat, various symptoms and signs of deficiency.For a long time clothes go dark complexion wild, and good color is moist, makes light of one's life by commiting suicide not old " < < Bencao Shiyi > > carries " main clever, adjust vim and vigour, make us strong ".
Rhizoma Atractylodis, acrid in the mouth is bitter, and temperature, enters spleen kidney channel, function, drying damp and strengthening spleen wind-damp dispelling, cures mainly: because of having loose bowels that dampness taste cause, inappetence, vomiting and nausea is unhappy, joint limbs pain, nyctalopia etc.; Modern pharmacological research: have antiinflammatory, antiulcer action, promote orgotein synthetic, prevention hepatocellular damage, blood sugar lowering oxygen lack resistant function.
The Radix Astragali, sweet in the mouth temperature enters lung spleen channel, function: qi-supplementing, blood-engendering, consolidating superficial resistance evacuation of pus, diuretic detumescent.Cure mainly: all cards of asthenia of qi and blood, modern pharmacological research: the Radix Astragali is containing Saponin, sucrose, polysaccharide, several amino acids, folic acid, the various trace elements such as selenium, zinc, copper.Have enhancing human body immunity, protect the liver, diuresis, defying age, anti-stress, adjusting blood pressure and antibacterial action more widely.
Semen Benincasae, is the seed of cucurbitaceous plant Fructus Benincasae, and sweet in the mouth cold nature lung meridian, is controlled phlegm-heat cough, lung abscess, acute appendicitis, leucorrhea, edema at removing heat from the lung and dissipating phlegm, eliminating carbuncle evacuation of pus, dampness removing.Pharmacology: have immunologic enhancement, strengthen body immunity, trypsin is had to inhibitory action), Rhizoma Dioscoreae: sweet in the mouth is put down into lung spleen kidney channel, function: tonifying the spleen and stomach, lung benefiting kidney, cures mainly: all deficient syndromes of lung spleen kidney; Modern pharmacological research: blood sugar lowering, promotes gastro-intestinal digestion absorption, anti-hypoxia, Promote immunity function, antioxidation.
Fructus Corni, the sweet temperature of puckery, enters Liver and kidney warp, function: nourishing the liver and kidney, arresting seminal emission hidroschesis, cures mainly: has a dizzy spell, soreness of the waist and knees, frequent micturition, sexual impotence hyperhidrosis etc.Modern pharmacological research: shock, antioxidation, defying age, regulates immunologic function, leukocyte increasing, diuretic antihypertensive, reduces whole blood viscosity, suppresses platelet, and antithrombotic forms, inflammation-inhibiting reaction blood sugar lowering.
Fructus Schisandrae Chinensis, sweet in the mouth temperature enters cardiopulmonary kidney channel.Function: the nourishing kidney of astringing the lung, arresting seminal emission quenches the thirst, promotes the production of body fluid, arresting sweating, mind tranquilizing and the heart calming.Modern pharmacological research: energy excitor nerve system maincenters at different levels, regulate cerebral cortex, reduce autonomic activities, irritability, calmness, convulsion, makes to tend to balance, hepatic cholagogic, antiulcer, anti-stress increases coronary flow, enhancing immunity, slow down aging, antiviral, two-ways regulation blood pressure, anti-infarction, anoxia enduring, resisting fatigue, anti-leukopenia, improves renal function.Improve vision, improve enzymatic activity.
Arillus Longan, warm in nature, taste is sweet.Cure mainly: invigorating the heart and spleen, nourishing blood to tranquillize the mind.For insufficiency of vital energy and blood, severe palpitation, forgetful insomnia, blood deficiency and yellow complexion.
Fructus Crataegi, the sweet temperature of sour in the mouth, enters taste Liver Channel, function: tonifying the spleen and stomach is aid digestion, and the meat that easily disappears is greasy, and infantile dyspepsia enters blood system blood circulation promoting and blood stasis dispelling.Modern pharmacological research: can improve proteinase activity, help carnivorous digestion, reduce fat, heart tonifying, resists myocardial ischemia, arrhythmia, antiplatelet aggregation, blood pressure lowering, blood fat reducing, alleviate arteriosclerosis, tranquilizing soporific, pain relieving, antioxidation, protects the liver, and promotes Mesentery microcirculation to recover, alleviating vascular spasm, strengthens immunologic function.
Cortex Moutan, cold nature, acrid in the mouth, nontoxic, enter the heart, liver, kidney three warps, there is dissipating blood stasis blood, purify the blood and blood, pain relieving, the effect of stimulating the menstrual flow, reduce blood pressure in addition, the effect of anti-inflammation, clothes can be lengthened the life by beneficial body for a long time.The regulating liver-QI that nourishes blood, loose strongly fragrant blood stasis dispelling, is applicable to chloasma faciei, and skin aging is often drunk the QI and blood lung of living, and appearance is ruddy, improves menoxenia, dysmenorrhea, sweating due to debility only, night sweat.
The Cortex Eucommiae, the pungent temperature of sweet in the mouth enters Liver and kidney warp.Function: tonifying liver and kidney and strengthening bones and muscles, blood pressure lowering, antiabortive, cure mainly: have a dizzy spell, the soreness of waist is unable sexual impotence, frequent micturition etc.Modern pharmacological research: energy two-ways regulation cellular immunization, increase phagocyte phagocytic function, adrenal cortex reinforcing function, promotes gonad development, blood vessel dilating, blood pressure lowering, serum cholesterol-lowering, calmness, analgesia, diuresis is antiabortive, defying age, anti-stress antitumor.
Radix Ophiopogonis, sweet in the mouth is cold in nature, GUIXIN lung stomach warp.Function: Yin-nourishing and body fluid promoting, the relieving restlessness of quenching the thirst.Cure mainly: lung-stomach yin deficiency heat-transformation, the constipation of cough dry throat and mouth, vexed not peaceful; Modern pharmacological research: containing various nutrient elements, the peripheral leukocytes that can raise, promote immunologic function, improve organism adaptation heart tonifying coronary artery dilating and peripheral blood vessel, increase its blood flow, arrhythmia, rising blood pressure, shock, improve hypoxia-bearing capability, blood sugar lowering, removes free radical and defying age.
Radix Platycodonis, bitter in the mouth is pungent cold, enters lung meridian.Function: lung qi dispersing eliminates the phlegm, evacuation of pus throat.Cure mainly: cough with copious phlegm, pharynx pain aphonia.Modern pharmacological research: have eliminating phlegm and relieving cough effect, blood sugar lowering, reduces cholesterol, loose smooth muscle and sedation and analgesia refrigeration function, prevention stress gastric ulcer, expansion peripheral blood vessel, blood pressure lowering, strengthens immunization.
Element culturing fixed folder of the present invention, beneficial heart the kidney invigorating, the smooth will of spleen of relaxing, strong liver damp eliminating, regulating the stomach and sending down the abnormal ascending QI, dispersing lung-QI and dissipating phlegm, the raw arteries and veins of QI invigorating, harmonizing yingfen and weifen, blood circulation promoting and blood stasis dispelling, the increasing intelligence of calming the nerves, safeguard human internal environment's equilibrium between yin and yang, QI and blood is vigorous, and function of five internal organs is coordinated, adaptive capacity to environment to external world is constantly promoted, the reserve of enhancing body, resistance, restoring force.
The specific embodiment
Embodiment 1
Chinese medicine formula:
Radix Ginseng 30 Radix Angelicae Sinensis 20 Rhizoma Polygonati 25 fresh ginger 10 Fructus Jujubae 25 Fructus Lycii 10 Radix Paeoniae Albas 20
Bulbus Lilii 25 Flos Spatholirionis longifolii 5 Radix Bupleuri 20 Rhizoma Polygonati Odorati 15 Rhizoma Atractylodis 15 Radix Astragali 30 Semen Benincasaes 10
Fructus Corni 10 Fructus Schisandrae Chinensis 20 Arillus Longan 10 Fructus Crataegi 20 Cortex Moutan 20 Cortex Eucommiae Radix Platycodoniss 20 10 Radix Ophiopogonis 15.
Preparation method: take according to said medicine share proportioning, mix, pulverize, sieve, according to a conventional method, water is general is ball,, be prepared as the watered pill of Semen phaseoli radiati grain size.
Embodiment 2
Chinese medicine formula:
Radix Ginseng 40 Radix Angelicae Sinensis 25 Rhizoma Polygonati 20 fresh ginger 8 Fructus Jujubae 15 Fructus Lycii 13 Radix Paeoniae Albas 22
Bulbus Lilii 20 Flos Spatholirionis longifolii 8 Radix Bupleuri 15 Rhizoma Polygonati Odorati 10 Rhizoma Atractylodis 15 Radix Astragali 35 Semen Benincasaes 15
Fructus Corni 5 Fructus Schisandrae Chinensis 25 Arillus Longan 10 Fructus Crataegi 15 Cortex Moutan 15 Cortex Eucommiae Radix Platycodoniss 10 5 Radix Ophiopogonis 15.
Preparation method: take above-mentioned Chinese crude drug by proportioning, first soak 1 hour, then decoct with water secondary, add for the first time 16 times of dose water, add for the first time 12 times of medicinal residues water gagings, decoct 2 hours at every turn, filter, collect filtrate, merge twice filtrate, standing, getting supernatant, to be evaporated to relative density be 1.10-1.15(50 ℃), spraying is dry, adds steviosin 2g, add dextrin and make in right amount 1000g, use 30% alcohol granulation, 60 ℃ dry, granulate, pack, obtains.
Embodiment 3
Chinese medicine formula:
Radix Ginseng 20 Radix Angelicae Sinensis 22 Rhizoma Polygonati 10 fresh ginger 15 Fructus Jujubae 25 Fructus Lycii 8 Radix Paeoniae Albas 25
Bulbus Lilii 20 Flos Spatholirionis longifolii 10 Radix Bupleuri 40 Rhizoma Polygonati Odorati 10 Rhizoma Atractylodis 15 Radix Astragali 35 Semen Benincasaes 10
Fructus Corni 12 Fructus Schisandrae Chinensis 25 Arillus Longan 10 Fructus Crataegi 30 Cortex Moutan 25 Cortex Eucommiae Radix Platycodoniss 20 10 Radix Ophiopogonis 5.
Preparation method: common process and the adjuvant of preparing honeyed pill by pharmacy of Chinese materia medica are prepared into honeyed pill.
Adopt embodiment 1-3 Chinese medicine preparation, according to the evaluation scheme of existing routine, use mice to carry out zoopery.At laboratory, prove in to mouse test, Chinese medicine composition of the present invention has 4 kinds of health cares: (1) significantly improves the metabolism intensity of its body internal protein, RNA in liver is than the weightening finish 30% (2) of contrast Mus because serum agglutination content improves 28%, and its immunity strengthens; (3) white mouse Seminal vesicle is than contrast Mus hypertrophy 39%, and levator ani weightening finish 47%, shows to promote that sexual organ's growth function is strong; (4) swimming endurance improves 20%, and under anoxia condition, survival period is long by 60%, has significant endurance function.
The clinical test results of Chinese medicine composition of the present invention below.
1, clinical observation object
From year June in July, 2009 to 2012, observe altogether 120 examples, the age is between 18 ~ 59 years old.
1. health check-up is without extremely but the continuous person that catches a cold throughout the year: observe 20 examples, wherein male's 6 examples, women's 14 examples.
2. health check-up is without spiritlessness and weakness person extremely but throughout the year: observe 20 examples, wherein male's 12 examples, women's 8 examples.
3. health check-up without extremely but throughout the year vexed or head as thing wrap up in, nose heave, dreaminess or bad dream, drowsiness, sleep and do not recover from fatigue or insomniac: observation 28 examples, wherein male's 12 examples, women's 16 examples.
4. health check-up is without feeling sick extremely but throughout the year or tending to vomit or anorexia; Have a nasty taste or without hunger sensation; Feeling thirst but no desire to drink or polydipsia and do not quench one's thirst; Constipation with dry stool or loose stool, feces filth, the not well person of defecation: observe 24 examples, wherein man, each 12 examples of female.
5. health check-up is without extremely, throughout the year normal the but conscious skin surface heating of body temperature or sweating is not smooth; Forgetful or cardiopalmus or bradykinesia; Emotion impassable patient: observe 28 examples, wherein man, each 14 examples of women.
2, Therapeutic Method and criterion
Watered pill medicine of the present invention: 3 times on the one, once take 5g.Serveing on 15 days is a course for the treatment of, observes at most for 3 courses for the treatment of.During treatment, eat less meat product and seafood, alcohol prohibition.Effect judgement: clinical manifestation all eliminate and follow up a case by regular visits to 1 year not recidivist be recovery from illness; Though eliminate more than 30% and follow up a case by regular visits to recurrence in 1 year but alleviator for effective; Other is invalid.
3, therapeutic outcome
1. health check-up is without extremely but the continuous person that catches a cold throughout the year: recovery from illness 16 examples, account for 80%; Effective 4 examples, account for 20%; Invalid 0 example.
2. health check-up is without spiritlessness and weakness person extremely but throughout the year: recovery from illness 17 examples, account for 85%; Effective 2 examples, account for 10%; Invalid 1 example, accounts for 5%.
3. health check-up without extremely but throughout the year vexed or head as thing wrap up in, nose heave, dreaminess or bad dream, drowsiness, sleep and do not recover from fatigue or insomniac: 22 examples of fully recovering, account for 78.6%; Effective 5 examples, account for 17.9%; Invalid 1 example, accounts for 3.5%.
4. health check-up is without feeling sick extremely but throughout the year or tending to vomit or anorexia; Have a nasty taste or without hunger sensation; Feeling thirst but no desire to drink or polydipsia and do not quench one's thirst; Constipation with dry stool or loose stool, feces filth, the not well person of defecation: recovery from illness 20 examples, account for 83.3%; Effective 4 examples, account for 16.7%; Invalid 0 example.
5. health check-up is without extremely, throughout the year normal the but conscious skin surface heating of body temperature or sweating is not smooth; Forgetful or cardiopalmus or bradykinesia; Emotion impassable patient: recovery from illness 23 examples, account for 82.1%, effective 3 examples, account for 10.7%; Invalid 2 examples, account for 7.2%.
Above-mentioned clinical trial proves, pharmaceutical composition of the present invention has the definite effect of taking good care of to the sub-health state because causing under immunity.