CN104758537A - A traditional Chinese medicine preparation for treating postherpetic neuralgia and a preparing method thereof - Google Patents
A traditional Chinese medicine preparation for treating postherpetic neuralgia and a preparing method thereof Download PDFInfo
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Abstract
The invention relates to a traditional Chinese medicine preparation for treating postherpetic neuralgia and a preparing method thereof. The preparation is prepared from following raw material medicines by weight: 14-16 parts of angelica dahurica, 12-18 parts of radix paeoniae alba, 15-25 parts of combined spicebush root, 1-3 parts of air potato, 8-10 parts of processed frankincense, 8-10 parts of processed myrrh, 3-5 parts of panax notoginseng, 1-3 parts of ligusticum wallichii, 5-7 parts of rhizoma corydalis, 8-10 parts of mint, 5-7 parts of draconis resin, 2-4 parts of borneol, 5-7 parts of licorice, 2-4 parts of manchurian wildginger, 10-14 parts of angelica sinensis, 5-8 parts of clove, 3-5 parts of nux vomica and 10-20 parts of azone having a concentration of 1%. The beneficial effects of the preparation and the preparing method are that: (1) local blood circulation is improved, blocked nerves are allowed to be clear, pain arresting effects are good, and the preparation is refreshing, cool and comfort; (2) external plaster application on affected parts can draw out toxins, remove blood stasis, and intercept virus spread, and the curative rate is high; and (3) the preparation is free of sequelae, convenient to use, free of side effects, rapid in production of effects, short in curative course, high in curative rate and convenient to carry.
Description
Technical field
The present invention relates to a kind of Chinese medicine preparation and preparation method, particularly a kind of Chinese medicine preparation and preparation method for the treatment of postherpetic neuralgia.
Background technology
Herpes zoster is the acute inflammation dermatoses caused by varicella zoster virus (Varicella zoster virus, VZV), and the traditional Chinese medical science is called skirt-roof HUOLONG, herpes zoster, is commonly called as herpes zoster, raw Serpentis.Its main feature, for bunch catchmenting bubble, to be trooped zonal distribution along side peripheral nerve, with obvious neuralgia.Primary infection shows as chickenpox, and later virus can be hidden for a long time at spinal cord posterior root ganglion, and immunologic function weakens that can to bring out varicella zoster virus movable once again, and growth and breeding, involves skin along peripheral nerve, and herpes zoster occurs.Have some patients after clinical symptom disappearance and transfer post herpetic neuralgia (PHN) to, be in puzzlement, one of the altauna disease of old people, the persistent period is short then 1 ~ 2 year, and elder is even more than 10 years, and general medical history is many in 3 ~ 5 years.Often show as locally paroxysmal or persistent causalgia, twinge, jumping pain, pain etc. of lancinating, belong to more violent intractable pain, touch gently and can produce insufferable having an intense pain, thus make patient's sleeping and eating difficulty peace, languish.Because its patient's condition is touching, more, the feature that the course of disease is long, makes radical cure postherpetic neuralgia very difficult to the chronic difficulty of glue.
At present, the method for western medical treatment PHN mainly adopts 1. antiviral drugs, as acyclovir, valaciclovir; 2. analgesic drug product, as analgesics, carbamazepine; 3. trophic nerve medicine, as vitamin B1, B12; 4. take neurolytic method, as nerve block, cut-out, retardance, freezing, laser irradiates, diathermy, uses analgesia pump, neurad root (or canalis spinalis) is inner injects hormone, anesthetis, interferon medicine etc., effect is not very definite, has many side effect simultaneously, wound is large, and the change of close observation leukocyte and thrombocytopenia, erythra and hepatic and renal function.Make a general survey of the clinical therapeutic effect for PHN of doctor trained in Western medicine unsatisfactory, the course for the treatment of is grown, curative effect is slow, the pain phase is long, side effect is many.
Summary of the invention
Object of the present invention is exactly in view of the foregoing defects the prior art has, a kind of Chinese medicine preparation and preparation method for the treatment of postherpetic neuralgia are provided, the present invention is that one makes medicine infiltrate its space between skin and muscles from skin mucosa, dredge the meridian passage, through sick institute, or put forward heresy and go out, or attack and loose method, extraordinary therapeutic effect is had to postherpetic neuralgia, use said preparation need not be wrapped up, debridement, directly allows drug effect in trouble face, can pull out rapidly the vicious carbuncle sore in trouble face, ease the pain rapidly, treat simple and quick.Have evident in efficacy, pain relieving rapid, easy to use, safe, the effect such as have no side effect.
A kind of Chinese medicine preparation for the treatment of postherpetic neuralgia, it is characterized in that being made up of the crude drug of following weight: Radix Angelicae Dahuricae 14-16 part, Radix Paeoniae Alba 12-18 part, Radix Linderae 15-25 part, Rhizoma Dioscoreae Bulbiferae 1-3 part, Olibanum (processed) 8-10 part, Myrrha (processed) 8-10 part, Radix Notoginseng 3-5 part, Rhizoma Chuanxiong 1-3 part, Rhizoma Corydalis 5-7 part, Herba Menthae 8-10 part, Sanguis Draxonis 5-7 part, Borneolum Syntheticum 2-4 part, Radix Glycyrrhizae 5-7 part, Herba Asari 2-4 part, Radix Angelicae Sinensis 10-14 part, Flos Caryophylli 5-8 part, Semen Strychni 3-5 part, 1% azone 10-20 part.
Preferably, the present invention is made up of the crude drug of following weight portion: the Radix Angelicae Dahuricae 15 parts, the Radix Paeoniae Alba 15 parts, the Radix Linderae 20 parts, Rhizoma Dioscoreae Bulbiferae 2 parts, Olibanum (processed) 9 parts, Myrrha (processed) 9 parts, Radix Notoginseng 4 parts, Rhizoma Chuanxiong 2 parts, Rhizoma Corydalis 6 parts, Herba Menthae 8-10 part, Sanguis Draxonis 6 parts, Borneolum Syntheticum 3 parts, 6 parts, Radix Glycyrrhizae, Herba Asari 3 parts, Radix Angelicae Sinensis 12 parts, Flos Caryophylli 7 parts, Semen Strychni 4 parts, 1% azone 15 parts.
A kind of preparation method for the treatment of the Chinese medicine preparation of postherpetic neuralgia that the present invention mentions, comprises the following steps:
First, Radix Angelicae Dahuricae 14-16 part, Radix Paeoniae Alba 12-18 part, Radix Linderae 15-25 part, Rhizoma Dioscoreae Bulbiferae 1-3 part, Olibanum (processed) 8-10 part, Myrrha (processed) 8-10 part, Radix Notoginseng 3-5 part, Rhizoma Chuanxiong 1-3 part, Rhizoma Corydalis 5-7 part, Herba Menthae 8-10 part, Sanguis Draxonis 5-7 part, Borneolum Syntheticum 2-4 part, Radix Glycyrrhizae 5-7 part, Herba Asari 2-4 part, Radix Angelicae Sinensis 10-14 part, Flos Caryophylli 5-8 part, Semen Strychni 3-5 part are made powder, fine powder wanted 120 mesh sieves, and the vinegar of adding 50 parts stirs for subsequent use and as a curative;
Secondly, 1% azone 10-20 part is heated to about 60 DEG C and shakes up, and mix homogeneously with described curative, form No. two curatives.
The clinical practice of Chinese medicine preparation of the present invention:
Clinically, adopting a medicine or No. two medicines according to the position that postherpetic neuralgia relates to, is that extremity (comprising) use No. two medicines with lower portion or the insensitive position of skin in principle.
The area mediation vinegar related to according to postherpetic neuralgia and the stirring ratio of dry powder, the consumption of vinegar can increase and decrease as one sees fit.In general, determine drug of topical application length and width according to trouble face, the drug of topical application is about 5mm highly about, and the method for PHN patient's medicine-feeding is such:
(1) affected part, extremity (not comprising) above position, by vinegar and medicated powder mixing and stirring, then takes out the medicine that stirring put into by the sizable gauze in same trouble face, gauze after soaking is taken out and is spread on affected part, repeated multiple times until be in harmonious proportion medicinal complete, outermost layer cover preservative film, in case medicinal liquid exosmoses.Every day 1 time.
(2) extremity (comprising) are with lower portion affected part, by 1% azone 15ml and No. one medicine mixing and stirring of heating, the dosage of azone can increase and decrease as one sees fit, then the medicine that stirring put into by the sizable gauze in same trouble face is taken out, gauze after soaking is taken out and is spread on affected part, repeated multiple times until be in harmonious proportion medicinal complete, outermost layer cover preservative film, in case medicinal liquid exosmoses.Every day 1 time.
(3) the pungent warming foods of fasting during medication, polyphagia bean product, fish, egg, lean meat etc. are rich in the food of protein and fresh gourd, fruit and vegetable.
(4) during medication, aspect is noted in action: unmovable or few movable, takes a good rest more; Note in emotion: unworried, not irritable, mood is optimistic.
Wherein, Radix Angelicae Dahuricae dispersing cold for relieving pain, detumescence and apocenosis, sensible, dehumidifying, expelling pathogenic wind from the body surface, to dispel the wind; The Radix Paeoniae Alba: beauty treatment, pain relieving, nourish blood, adjust battalion to defend, easing the affected liver of enriching blood;
the Radix Linderae: promoting the circulation of QI to relieve pain, warming kidney for dispelling cold;
rhizoma Dioscoreae Bulbiferae: removing heat from blood, pathogenic fire reducing, disappear wart, removing toxic substances; Olibanum (processed): regulating qi and activating blood, analgesic therapy, chases after poison, controls coagulation of QI-blood, carbuncle pyogenic infections from tumour or sore; Myrrha (processed): loose blood is dispelled silt, reducing swelling and alleviating pain;
radix Notoginseng: activating blood and removing stasis, hemostasis, reducing swelling and alleviating pain;
rhizoma Chuanxiong: blood-activating and qi-promoting, wind-expelling pain-stopping;
rhizoma Corydalis: for whole body each portion qi depression to blood stasis pain;
herba Menthae: Herba Menthae topical application has effect of refrigerant, antipruritic, antiinflammatory, pain relieving; Sanguis Draxonis: hemostasis and pain-relieving, dissipating blood stasis tissue regeneration promoting, blood activating and promoting tissue regeneration; Borneolum Syntheticum: control carbuncle, logical all keys, loose stagnated fire, reducing swelling and alleviating pain; Radix Glycyrrhizae: relieving spasm to stop pain, regulates all medicines, for wrist abdomen, extremity contraction anxious pain, carbuncle sore tumefacting virus; Herba Asari: wind-expelling pain-stopping, local anaesthesia, calmness; Radix Angelicae Sinensis: enrich blood invigorate blood circulation, pain relieving, for rheumatic arthralgia, traumatic injury, ulcer sores; Flos Caryophylli: regulating QI and lowering the adverseness, warming middle-JIAO to relieve pain, warming the kidney; Semen Strychni: promoting blood circulation to remove obstruction in the collateral, except wind damp eliminating, antiphlogistic antibacterial, pain relieving, expelling the stasis for the new;
Azone: be that oil-soluble azone becomes efficient water soluble product through modification, obvious transdermal is all had to help the effect of oozing to oleophylic, hydrophilic medicament and active component, keratodermatitis and lipid are interacted, reduce the phase inversion temperature of active substance to lipid in horny layer gap, add mobility, diffusional resistance in horny layer of medicine or active additive is reduced, therefore plays and very strong shortly ooze effect.
The invention has the beneficial effects as follows: (1) improves local blood circulation, impel the nerve of retardance unimpeded, good analgesic effect, clearly comfortable; (2) external application of affected part plaster can poison drawing stagnation resolving, and stop virus spread, cure rate is high; (3) do not stay sequela, easy to use, have no side effect, advantage main is in a word relative to existing doctor trained in Western medicine and the traditional Chinese medical science, instant effect, short treating period, and cure rate is high, few side effects, and the usage and dosage of this medicine is easily grasped, easy to carry.
Detailed description of the invention
Embodiment 1: the present invention is made up of the crude drug of following weight portion: Radix Angelicae Dahuricae 14g, Radix Paeoniae Alba 12g, Radix Linderae 15g, Rhizoma Dioscoreae Bulbiferae 1g Olibanum (processed) 8g, Myrrha (processed) 8g, Radix Notoginseng 3g, Rhizoma Chuanxiong 1g, Rhizoma Corydalis 5g, Herba Menthae 8g, Sanguis Draxonis 5g, Borneolum Syntheticum 2g, Radix Glycyrrhizae 5g, Herba Asari 2g, Radix Angelicae Sinensis 10g, Flos Caryophylli 5g, Semen Strychni 3g, 1% azone 10ml.
Its manufacture method is: the Radix Angelicae Dahuricae, the Radix Paeoniae Alba, the Radix Linderae, Rhizoma Dioscoreae Bulbiferae, Olibanum (processed), Myrrha (processed), Radix Notoginseng, Rhizoma Chuanxiong, Rhizoma Corydalis, Herba Menthae, Sanguis Draxonis, Borneolum Syntheticum, Radix Glycyrrhizae, Herba Asari, Radix Angelicae Sinensis, Flos Caryophylli, Semen Strychni make powder, adds appropriate vinegar and stirs for subsequent use and as a curative.
In addition, 1% azone 10ml is heated to about 60 DEG C and shakes up, and mix homogeneously with described curative, form No. two curatives.
During treatment, (1) affected part, extremity (not comprising) above position, a medicated powder of proper amount of edible vinegar and 5 grams is mixed, certainly, the consumption of vinegar can increase and decrease as one sees fit, and dry wet mixing and stirring, then takes out the medicine that stirring put into by the sizable gauze in same trouble face, gauze after soaking is taken out and is spread on affected part, 1 time on the one.
(2) extremity (comprising) are with lower portion affected part, by 1% azone 10ml and No. two medicated powder mixing, certainly, the dosage of azone can increase and decrease as one sees fit, dry wet mixing and stirring, then take out the medicine that stirring put into by the sizable gauze in same trouble face, the gauze after soaking is taken out and is spread on affected part, 1 time on the one, a few days fully recovers.
Embodiment 2: the present invention is made up of the crude drug of following weight portion: Radix Angelicae Dahuricae 16g, Radix Paeoniae Alba 18g, Radix Linderae 25g, Rhizoma Dioscoreae Bulbiferae 3g, Olibanum (processed) 10g, Myrrha (processed) 10g, Radix Notoginseng 5g, Rhizoma Chuanxiong 3g, Rhizoma Corydalis 7g, Herba Menthae 10g, Sanguis Draxonis 7g, Borneolum Syntheticum 4g, Radix Glycyrrhizae 7g, Herba Asari 4g, Radix Angelicae Sinensis 14g, Flos Caryophylli 8g, Semen Strychni 5g, 1% azone 20ml.
Its preparation and Therapeutic Method, with embodiment 1, form No. one and No. two curatives.
Embodiment 3: the present invention is made up of the crude drug of following weight portion: Radix Angelicae Dahuricae 15g, Radix Paeoniae Alba 15g, Radix Linderae 20g, Rhizoma Dioscoreae Bulbiferae 2g, Olibanum (processed) 9g, Myrrha (processed) 9g, Radix Notoginseng 4g, Rhizoma Chuanxiong 2g, Rhizoma Corydalis 6g, Herba Menthae 9g, Sanguis Draxonis 6g, Borneolum Syntheticum 3g, Radix Glycyrrhizae 6g, Herba Asari 3g, Radix Angelicae Sinensis 12g, Flos Caryophylli 7g, Semen Strychni 4g, 1% azone 15ml.
Preparation and Therapeutic Method, with embodiment 1, form No. one and No. two curatives.
Clinical efficacy of the present invention:
The present invention, according to existing regulation, with reference to " disease of tcm diagnostic criteria " that State Administration of Traditional Chinese Medicine promulgates for 1994, is divided into clinical recovery, effective, effective and invalid four grades therapeutic effect.Clinical test results is as follows for many years: object be 50-70 year patients with post herpetic neuralgia, existing by as follows for curative effect statistics:
1, use embodiment 1 formula treatment postherpetic neuralgia treat altogether 52 example, wherein clinical recovery 45 example, account for 86.5%; Effective 3 examples, account for 5.7%; Effective 1 example, accounts for 1.9%; Invalid 3, account for 5.7%.Effective percentage accounts for 94.3%.
2, use embodiment 2 formula treatment postherpetic neuralgia 44 example, wherein clinical recovery 39 example, account for 88.6%; Effective 2 examples, account for 4.5%; Effective 1 example, accounts for 2.2%; Invalid 2, account for 4.5%.Effective percentage accounts for 95.5%.
3, use embodiment 3 formula treatment postherpetic neuralgia 61 example, wherein clinical recovery 54 example, account for 88.5%; Effective 4 examples, account for 6.6%; Effective 1 example, accounts for 1.6%; Invalid 2, account for 3.3%.Effective percentage accounts for 96.7%.
Implement cases total number of cases 157 example for above three kinds, wherein clinical recovery 138 example, account for 87.9%; Effective 9 examples, account for 5.7%; Effective 3 examples, account for 1.9%; Invalid 7, account for 4.5%.Effective percentage accounts for 95.5%.
Wherein, model case is as follows:
King so-and-so, man, 65 years old.2010, there is electric shock sample paroxysmal pain for latter 12 months in right side side of body flank skin herpes zoster recovery from illness, with under right rib and epigastrium be very, hurt like hell, with pain disappearance in 20 minutes after a medicine, fully recovers for 11 days.
Lee so-and-so, man, 72 years old.2011, there is obvious paraesthesia, the sense of ant row for latter 20 days, itch, tightly restraint the abnormal sensories such as sense, feeling of numbness and variable interval twitch, pain in right nape and the incrustation of right upper extremity herpes zoster, with a medicine 25 minutes, feels to alleviate, after 35 minutes, pain disappears, recovery from illness in 15 days.
Zhang, female, 69 years old, 2012, patient to suffer from after herpes zoster left lower extremity knee joint part hurt like hell more than May, burns sample pain, have a strong impact on sleep in pinprick sample, and to use after No. two medicines 10 minutes, pain relief, after 20 minutes, pain disappears, and is almost recovered after 25 days.
Zhao so-and-so, man, 75 years old, 2013, after patient's right face herpes zoster 3 months, the migrans pain of whole body, painful area comprised face, abdominal part, back etc., and pain again and again occurs as electric discharge, and pain is not for raw.Patient to use after a medicine 10 minutes, and abdominal part and back pain alleviate, 25 minutes rear face pain reliefs, and treatment is after 30 days continuously, is almost recovered.
Claims (3)
1. treat the Chinese medicine preparation of postherpetic neuralgia for one kind, it is characterized in that being made up of the crude drug of following weight: Radix Angelicae Dahuricae 14-16 part, Radix Paeoniae Alba 12-18 part, Radix Linderae 15-25 part, Rhizoma Dioscoreae Bulbiferae 1-3 part, Olibanum (processed) 8-10 part, Myrrha (processed) 8-10 part, Radix Notoginseng 3-5 part, Rhizoma Chuanxiong 1-3 part, Rhizoma Corydalis 5-7 part, Herba Menthae 8-10 part, Sanguis Draxonis 5-7 part, Borneolum Syntheticum 2-4 part, Radix Glycyrrhizae 5-7 part, Herba Asari 2-4 part, Radix Angelicae Sinensis 10-14 part, Flos Caryophylli 5-8 part, Semen Strychni 3-5 part, 1% azone 10-20 part.
2. the Chinese medicine preparation for the treatment of postherpetic neuralgia according to claim 1, is characterized in that being made up of the crude drug of following weight portion: the Radix Angelicae Dahuricae 15 parts, the Radix Paeoniae Alba 15 parts, the Radix Linderae 20 parts, Rhizoma Dioscoreae Bulbiferae 2 parts, Olibanum (processed) 9 parts, Myrrha (processed) 9 parts, Radix Notoginseng 4 parts, Rhizoma Chuanxiong 2 parts, Rhizoma Corydalis 6 parts, Herba Menthae 8-10 part, Sanguis Draxonis 6 parts, Borneolum Syntheticum 3 parts, 6 parts, Radix Glycyrrhizae, Herba Asari 3 parts, Radix Angelicae Sinensis 12 parts, Flos Caryophylli 7 parts, Semen Strychni 4 parts, 1% azone 15 parts.
3. a preparation method for the Chinese medicine preparation for the treatment of postherpetic neuralgia as claimed in claim 1 or 2, is characterized in that comprising the following steps:
First, Radix Angelicae Dahuricae 14-16 part, Radix Paeoniae Alba 12-18 part, Radix Linderae 15-25 part, Rhizoma Dioscoreae Bulbiferae 1-3 part, Olibanum (processed) 8-10 part, Myrrha (processed) 8-10 part, Radix Notoginseng 3-5 part, Rhizoma Chuanxiong 1-3 part, Rhizoma Corydalis 5-7 part, Herba Menthae 8-10 part, Sanguis Draxonis 5-7 part, Borneolum Syntheticum 2-4 part, Radix Glycyrrhizae 5-7 part, Herba Asari 2-4 part, Radix Angelicae Sinensis 10-14 part, Flos Caryophylli 5-8 part, Semen Strychni 3-5 part are made powder, fine powder wanted 120 mesh sieves, and the vinegar of adding 50 parts stirs for subsequent use and as a curative;
Secondly, 1% azone 10-20 part is heated to about 60 DEG C and shakes up, and mix homogeneously with described curative, form No. two curatives.
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| CN106511890A (en) * | 2016-10-27 | 2017-03-22 | 谭奇纹 | Traditional Chinese medicine used for treating postherpetic neuralgia |
| CN106540028A (en) * | 2016-12-14 | 2017-03-29 | 广西中医药大学 | A kind of external Yao medicinal composition and preparation method thereof and including the medicine of the Yao medicinal composition |
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| CN105853492B (en) * | 2016-05-18 | 2021-02-09 | 刘根元 | Plaster for treating herpes zoster and preparation method thereof |
| CN106511890A (en) * | 2016-10-27 | 2017-03-22 | 谭奇纹 | Traditional Chinese medicine used for treating postherpetic neuralgia |
| CN106540028A (en) * | 2016-12-14 | 2017-03-29 | 广西中医药大学 | A kind of external Yao medicinal composition and preparation method thereof and including the medicine of the Yao medicinal composition |
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Application publication date: 20150708 |