CN104758436A - Traditional Chinese medicine composition for treating Qi and blood deficiency type of myasthenia gravis - Google Patents
Traditional Chinese medicine composition for treating Qi and blood deficiency type of myasthenia gravis Download PDFInfo
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- CN104758436A CN104758436A CN201410293830.8A CN201410293830A CN104758436A CN 104758436 A CN104758436 A CN 104758436A CN 201410293830 A CN201410293830 A CN 201410293830A CN 104758436 A CN104758436 A CN 104758436A
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Abstract
The invention relates to a traditional Chinese medicine composition for treating Qi and blood deficiency type of myasthenia gravis. The composition is prepared from the following pharmaceutical raw materials by weight: 12-18g of Radix Astragali, 12-18 g of Codonopsis pilosula, 12-18g of Rhizoma Atractylodis Macrocephalae, 8-12g of Chinese angelica, 20-30g of prepared rhizome of rehmannia, 8-12g of radices paeoniae alba, 8-12g of jujube, 4-8g of honey-fried licorice root, 2-10g of orange peel, 2-10g of cimicifuga foetida and 2-10g of radix bupleuri. Clinic test proves that the composition can safely and effectively treat myasthenia gravis of Qi and blood deficiency type.
Description
Technical field
The present invention relates to a kind of technical field of Chinese medicines, particularly relate to a kind of Chinese medicine composition for the treatment of both Qi and blood deficiency myasthenia gravis.
Background technology
Myasthenia gravis belongs to the traditional Chinese medical science " myopathy " category, is a kind of based on the autoimmune disease of neuromuscular junction pathological changes, is one of modern times intractable disease.With muscle fatiguability, light dusk in morning is heavy, have a rest after alleviate as feature, have the tendency of alleviation and recurrent exerbation, some patient has family history.The case of external report is common with 20 years old-40 years old, and domestic report is then many with child and less than 20 years old, and women is more than male.Light-duty patient only has upper eyelid sagging, and Rotation of eyeball is dumb, the impaired symptom of the eye muscle such as diplopia, stravismus; Heavy patient then has whole body tired, dynamic then weak, masticatory atonia, dysphagia, counter choking of drinking water, even the symptom such as dyspnea.Few patients can with amyotrophy, and some patients can bring out myasthenic crisis and threat to life due to many reasons.Doctor trained in Western medicine there is no specific treatment to primary disease at present, adopt the method such as prednisone, immunosuppressant, neostigmine, radiotherapy chemotherapy, plasmapheresis, thymusectomy, but the course for the treatment of is long clinical more, and side effect is large, and curative effect is unsatisfied with.
The traditional Chinese medical science has abundant understanding to primary disease, and treatment has some superiority.The traditional Chinese medical science is thought, spleen-kidney deficiency, insufficiency of vital energy and blood, and body muscle loses and supports is its basic pathogenesis, and differentiation of symptoms and signs for classification of syndrome comprises qi-deficiency of spleen and stomach, yang deficiency of spleen and stomache, liver-kidney yin deficiency, deficiency of both QI and blood, deficiency of kidney yin type.The traditional Chinese medical science is according to the Therapeutic Principle of " deficiency syndrome should be treated by tonifying method, damage person's benefit ", " sunken then rise it ", and with invigorating the spleen and benefiting QI, benefiting vital QI and blood, nourishing the liver and kidney, temperature male wind-supplying kidney is base therapy method, and is aided with promoting blood circulation by removing blood stasis, the therapies such as relaxing muscles and tendons and activating QI and blood in the collateral.Because the curative effect of Chinese medicine myasthenia gravis is reliable and stable, not easily recur after healing, treatment by Chinese herbs myasthenia gravis presents very wide prospect.But still lack effective for the dialectical Chinese medicine treated of both Qi and blood deficiency myasthenia gravis.
Summary of the invention
The present invention, by selecting suitable medical material and proportioning thereof, aims to provide the Chinese medicine of a kind of energy safe and effective treatment both Qi and blood deficiency myasthenia gravis.
For achieving the above object, the present invention is by the following technical solutions: a kind of Chinese medicine composition for the treatment of both Qi and blood deficiency myasthenia gravis, is made up: Radix Astragali 12-18g, Radix Codonopsis 12-18g, Rhizoma Atractylodis Macrocephalae 12-18g, Radix Angelicae Sinensis 8-12g, Radix Rehmanniae Preparata 20-30g, Radix Paeoniae Alba 8-12g, Fructus Jujubae 8-12g, Radix Glycyrrhizae Preparata 4-8g, Pericarpium Citri tangerinae 2-10g, Rhizoma Cimicifugae 2-10g, Radix Bupleuri 2-10g of the crude drug of following weight portion.
The Chinese medicine composition of described treatment both Qi and blood deficiency myasthenia gravis, it is preferably: be made up of the crude drug of following weight portion: Radix Astragali 15g, Radix Codonopsis 15g, Rhizoma Atractylodis Macrocephalae 15g, Radix Angelicae Sinensis 10g, Radix Rehmanniae Preparata 25g, Radix Paeoniae Alba 10g, Fructus Jujubae 10g, Radix Glycyrrhizae Preparata 6g, Pericarpium Citri tangerinae 6g, Rhizoma Cimicifugae 6g, Radix Bupleuri 6g.
The preparation method of the Chinese medicine composition of described treatment both Qi and blood deficiency myasthenia gravis, is characterized in that: Chinese medicinal preparation method is routinely made and is suitable for medicinal oral drugs.
The application of Chinese medicine composition in preparation treatment both Qi and blood deficiency myasthenia gravis of described treatment both Qi and blood deficiency myasthenia gravis.
Below in conjunction with Chinese medicine mechanism, beneficial effect of the present invention is described:
Inventor thinks, the pathogenesis of both Qi and blood deficiency myasthenia gravis is: blood is cloudy liquid, has moist, flourish foster effect; Qi being the governor of blood, the capable then blood of gas, the motion of human body body fluid has substantial connection with the promotion of gas invariably, and the deficiency of vital energy can not promote blood vessels, insufficiency of vital energy and blood, flourishly can not support muscle muscle arteries and veins, then cause flaccidity.Its syndrome: spiritlessness and weakness, shortness of breath and palpitation, deficiency of QI with disinclination to talk, Mian Se Koushi is white, and eyelid is unable, dysmasesis, and flesh withers unable, spontaneous perspiration, pale tongue, and corpulent tongue is tender indentation, white and thin fur, deep-thready pulse.Syndrome analysis: insufficiency of vital energy and blood, brain is become homeless foster, therefore spiritlessness and weakness, eyelid is unable, dysmasesis, and Mian Se Koushi is white; Deficiency of heart-blood, then shortness of breath and palpitation, spleen governing muscles, The spleen has the function to transport and transform nutrients, deficiency of spleen-QI transporting mistake department, then foodstuff essence is micro-can not moisten foster limb muscle, therefore amyotrophy; Pale tongue, there is indentation on the tender limit of corpulent tongue, and white and thin fur, deep-thready pulse are the sign of QI and blood deficiency.
The present invention, according to the Therapeutic Principle of " deficiency syndrome should be treated by tonifying method, damage person's benefit ", " sunken then rise it ", adopts suitable medical material and proportioning thereof to treat primary disease.Reusing the Radix Astragali in side, sweet in the mouth tepor, enter spleen, lung meridian, invigorating the spleen and replenishing QI, yang invigorating consolidating superficial resistance, is monarch drug.Compatibility Radix Codonopsis, the Rhizoma Atractylodis Macrocephalae, Radix Glycyrrhizae Preparata air making-up and spleen enlivening are minister, share with the Radix Astragali, to strengthen the merit of its strengthening QI of middle-JIAO.The deficiency of vital energy and blood, thus when joining Radix Rehmanniae Preparata with Radix Angelicae Sinensis, the Radix Paeoniae Alba, Fructus Jujubae nourish blood, association's Radix Codonopsis, the Radix Astragali are with benefiting qi and nourishing blood; Pericarpium Citri tangerinae regulating qi-flowing for harmonizing stomach, makes all medicine tonifys without causing stagnation, is adjuvant drug altogether.And with a small amount of Rhizoma Cimicifugae, Radix Bupleuri ascending up spleen-Qi and Yang, gas among assistance monarch drug sink with ascending.Comprehensive full side, compatibility ascending medicine and the same use of benefiting qi and nourishing blood medicine, have air making-up and spleen enlivening, a function of the ascending spleen-QI that nourishes blood, to realize the object for the treatment of both Qi and blood deficiency myasthenia gravis.
Below in conjunction with clinical trial, beneficial effect of the present invention is described:
1. physical data inventor accepted both Qi and blood deficiency Patients With Myasthenia Gravis 120 example altogether for medical treatment between December to 2013 year JIUYUE in 2005, wherein man 49 example, female 71 example, 16 ~ 53 years old age.Be divided at random: each 60 examples for the treatment of group, matched group.The physical data such as two groups of sexes, age, state of an illness there are no significant difference, has comparability.
2. experimental technique
The oral pyridostigmine bromide sheet of matched group, uses to specifications.
The decoction that the oral the present invention for the treatment of group makes, every day 1 dose, divides and takes for 2 times, 1-3 month course for the treatment of.
3. criterion of therapeutical effect
Recovery from illness clinical symptoms all disappears; Drug withdrawal has no recurrence in two months.
Improvement clinical symptoms obviously alleviates;
Invalid clinical symptoms is without being clearly better or increasing the weight of.
4. therapeutic outcome
Table 1 liang group comparitive study
Test finds that treatment group cure rate and total effective rate are all apparently higher than matched group (P < 0.05), and treatment group has no adverse reaction, and matched group adverse reaction rate is 40%.Show that the present invention can safe and effective treatment both Qi and blood deficiency myasthenia gravis.
5. model case
Case 1. Wang, female, 29 years old, in January, 2011 went to a doctor.Dual-eyelid is sagging, diplopia companion dizziness, lack of appetite, menoxenia April.Occur bilateral blepharoptosis, diplopia after patient's cause in April is overworked, light dusk in morning is heavy, alleviates, tired postemphasis after rest.Confirm as myasthenia gravis through Shuo Jia hospital, the western medical treatment state of an illness is without being clearly better.For further systematic treating, carry out my institute's hospitalization.Have a medical check-up: looks of becoming thin, shallow complexion, light red tongue is tender, thin white fur of tongue, thready and weak pulse.Dual-eyelid is sagging, and ocular movemeut is dumb.Be diagnosed as both Qi and blood deficiency myasthenia gravis.Yang deficiency of spleen and stomache myasthenia gravis take the present invention after 1 month all disease having subtract, then after adding 2 months, palpebral fissure recovers normal completely.Follow up a case by regular visits to after 1 year without recurrence.
Case 2. Lee, man, 17 years old, in January, 2008 went to a doctor.Find myasthenia of limbs, difficulty in walking 1 week.Myasthenia of limbs was there is, difficulty in walking before 1 week.Row neostigmine test confirms as myasthenia gravis, gives the oral rear symptom of pyridostigmine bromide and slightly improves.For asking further systematic treating, carry out my institute's hospitalization.Have a medical check-up: looks of becoming thin, shallow complexion, light red tongue is tender, thin white fur of tongue, thready and weak pulse.Two upper extremity strength IV grade, two lower upper extremity strength III level.Be diagnosed as both Qi and blood deficiency myasthenia gravis.Take the present invention after 1 month myasthenia of limbs comparatively before improve obviously, after 3 months, patient's extremity Myodynamia recovery is as usual.Follow up a case by regular visits to after 1 year without recurrence.
Detailed description of the invention:
Embodiment 1
Treat a Chinese medicine composition for both Qi and blood deficiency myasthenia gravis, be made up of the crude drug of following weight portion: Radix Astragali 18g, Radix Codonopsis 18g, Rhizoma Atractylodis Macrocephalae 18g, Radix Angelicae Sinensis 12g, Radix Rehmanniae Preparata 30g, Radix Paeoniae Alba 12g, Fructus Jujubae 12g, Radix Glycyrrhizae Preparata 8g, Pericarpium Citri tangerinae 10g, Rhizoma Cimicifugae 10g, Radix Bupleuri 10g.
Its preparation method is: Chinese medicinal preparation method is routinely made and is suitable for medicinal oral drugs.
Embodiment 2
Treat a Chinese medicine composition for both Qi and blood deficiency myasthenia gravis, be made up of the crude drug of following weight portion: Radix Astragali 15g, Radix Codonopsis 15g, Rhizoma Atractylodis Macrocephalae 15g, Radix Angelicae Sinensis 10g, Radix Rehmanniae Preparata 25g, Radix Paeoniae Alba 10g, Fructus Jujubae 10g, Radix Glycyrrhizae Preparata 6g, Pericarpium Citri tangerinae 6g, Rhizoma Cimicifugae 6g, Radix Bupleuri 6g.
Its preparation method is: Chinese medicinal preparation method is routinely made and is suitable for medicinal oral drugs.
Embodiment 3
Treat a Chinese medicine composition for both Qi and blood deficiency myasthenia gravis, be made up of the crude drug of following weight portion: Radix Astragali 12g, Radix Codonopsis 12g, Rhizoma Atractylodis Macrocephalae 12g, Radix Angelicae Sinensis 8g, Radix Rehmanniae Preparata 20g, Radix Paeoniae Alba 8g, Fructus Jujubae 8g, Radix Glycyrrhizae Preparata 4g, Pericarpium Citri tangerinae 2g, Rhizoma Cimicifugae 2g, Radix Bupleuri 2g.
Its preparation method is: Chinese medicinal preparation method is routinely made and is suitable for medicinal oral drugs.
Claims (4)
1. treat a Chinese medicine composition for both Qi and blood deficiency myasthenia gravis, be made up of the crude drug of following weight portion: Radix Astragali 12-18g, Radix Codonopsis 12-18g, Rhizoma Atractylodis Macrocephalae 12-18g, Radix Angelicae Sinensis 8-12g, Radix Rehmanniae Preparata 20-30g, Radix Paeoniae Alba 8-12g, Fructus Jujubae 8-12g, Radix Glycyrrhizae Preparata 4-8g, Pericarpium Citri tangerinae 2-10g, Rhizoma Cimicifugae 2-10g, Radix Bupleuri 2-10g.
2. the Chinese medicine composition for the treatment of both Qi and blood deficiency myasthenia gravis according to claim 1, it is preferably: be made up of the crude drug of following weight portion: Radix Astragali 15g, Radix Codonopsis 15g, Rhizoma Atractylodis Macrocephalae 15g, Radix Angelicae Sinensis 10g, Radix Rehmanniae Preparata 25g, Radix Paeoniae Alba 10g, Fructus Jujubae 10g, Radix Glycyrrhizae Preparata 6g, Pericarpium Citri tangerinae 6g, Rhizoma Cimicifugae 6g, Radix Bupleuri 6g.
3. the preparation method of the Chinese medicine composition for the treatment of both Qi and blood deficiency myasthenia gravis according to claim 1 and 2, is characterized in that: Chinese medicinal preparation method is routinely made and is suitable for medicinal oral drugs.
4. the application of Chinese medicine composition in preparation treatment both Qi and blood deficiency myasthenia gravis for the treatment of both Qi and blood deficiency myasthenia gravis according to claim 1 and 2.
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN108524775A (en) * | 2018-07-13 | 2018-09-14 | 乞国艳 | Application of the Chinese medicine in the pharmaceutical preparation for preparing treatment Myasthenia Gravis Associated with Thymoma |
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| CN1824028A (en) * | 2005-12-20 | 2006-08-30 | 马振春 | Formula of Chinese medicine health protection wine |
| CN102335402A (en) * | 2010-07-22 | 2012-02-01 | 江西济民可信集团有限公司 | Detection method of Chinese preparation mixture for invigorating the spleen and replenishing qi |
| CN104435245A (en) * | 2014-09-22 | 2015-03-25 | 刘德刚 | Traditional Chinese medicine for treating myasthenia |
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| CN1824028A (en) * | 2005-12-20 | 2006-08-30 | 马振春 | Formula of Chinese medicine health protection wine |
| CN102335402A (en) * | 2010-07-22 | 2012-02-01 | 江西济民可信集团有限公司 | Detection method of Chinese preparation mixture for invigorating the spleen and replenishing qi |
| CN104435245A (en) * | 2014-09-22 | 2015-03-25 | 刘德刚 | Traditional Chinese medicine for treating myasthenia |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108524775A (en) * | 2018-07-13 | 2018-09-14 | 乞国艳 | Application of the Chinese medicine in the pharmaceutical preparation for preparing treatment Myasthenia Gravis Associated with Thymoma |
| CN108524775B (en) * | 2018-07-13 | 2021-03-23 | 乞国艳 | Application of traditional Chinese medicine in preparation of medicinal preparation for treating myasthenia gravis combined with thymoma |
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| CN104758436B (en) | 2017-12-12 |
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