CN104755927A - 用于确定受试者对以自由基引起的dna损伤为特征的疾病状态的倾向的方法和分析产品 - Google Patents

用于确定受试者对以自由基引起的dna损伤为特征的疾病状态的倾向的方法和分析产品 Download PDF

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Publication number
CN104755927A
CN104755927A CN201380047021.2A CN201380047021A CN104755927A CN 104755927 A CN104755927 A CN 104755927A CN 201380047021 A CN201380047021 A CN 201380047021A CN 104755927 A CN104755927 A CN 104755927A
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China
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sample
whole blood
exposed
cancer
radiation
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CN201380047021.2A
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English (en)
Chinese (zh)
Inventor
戴安娜·安德森
摩根·纳加弗扎德
摩根·克莱夫·托马斯·德尼尔
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University of Bradford
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University of Bradford
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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/483—Physical analysis of biological material
    • G01N33/487—Physical analysis of biological material of liquid biological material
    • G01N33/49—Blood
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/50—Determining the risk of developing a disease
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/70—Mechanisms involved in disease identification
    • G01N2800/7004—Stress
    • G01N2800/7009—Oxidative stress
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/70—Mechanisms involved in disease identification
    • G01N2800/7023—(Hyper)proliferation
    • G01N2800/7028—Cancer

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • Hematology (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • Urology & Nephrology (AREA)
  • Ecology (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
CN201380047021.2A 2012-09-11 2013-09-10 用于确定受试者对以自由基引起的dna损伤为特征的疾病状态的倾向的方法和分析产品 Pending CN104755927A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GBGB1216174.1A GB201216174D0 (en) 2012-09-11 2012-09-11 Method of determining a predisposition to disease states characterised by free redical induced dna damage
GB1216174.1 2012-09-11
PCT/GB2013/052365 WO2014041340A1 (en) 2012-09-11 2013-09-10 Methods of, and assay products for, determining the predisposition of a subject to disease states characterised by free radical induced dna damage

Publications (1)

Publication Number Publication Date
CN104755927A true CN104755927A (zh) 2015-07-01

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
CN201380047021.2A Pending CN104755927A (zh) 2012-09-11 2013-09-10 用于确定受试者对以自由基引起的dna损伤为特征的疾病状态的倾向的方法和分析产品

Country Status (7)

Country Link
US (1) US20150219619A1 (https=)
EP (1) EP2895853A1 (https=)
JP (1) JP2015529077A (https=)
CN (1) CN104755927A (https=)
GB (1) GB201216174D0 (https=)
IN (1) IN2015DN02685A (https=)
WO (1) WO2014041340A1 (https=)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9931634B2 (en) 2014-02-27 2018-04-03 The Regents Of The Univeristy Of California High throughput DNA damage quantification of human tissue with home-based collection device
EP4006527B1 (en) * 2019-07-25 2025-07-16 Seoul Viosys Co., Ltd Light irradiation apparatus comprising led and method of using the same
CN116648620A (zh) 2020-10-22 2023-08-25 四维生命技术股份有限公司 作为用于检测癌症和癌症易感性的新生物标志物的dna损伤敏感性

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2638750A1 (en) * 2006-03-02 2007-09-13 Laboratory Corporation Of America Holdings Methods and systems for evaluating health risk factors by measurement of dna damage and dna repair

Non-Patent Citations (7)

* Cited by examiner, † Cited by third party
Title
DANIEL T. SAHA ET AL: "Quantification of DNA repair capacity in whole blood of patients with head and neck cancer and healthy donors by comet assay", <MUTATION RESEARCH.GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS> *
FRANCESCA MARCON ET AL: "Assessment of individual sensitivity to ionizing radiation and DNA repair efficiency in a healthy population", <MUTATION RESEARCH> *
M.H.L. GREEN ET AL: "UV-C sensitivity of unstimulated and stimulated human lymphocytes from normal and xeroderma pigmentosum donors in the comet assay: A potential diagnostic technique", <MUTATION RESEARCH, DNA REPAIR> *
VERA GARAJ-VRHOVAC ET AL: "Comet assay in the assessment of the human genome damage induced by γ-radiation in vitro", <RADIOL ONCOL> *
张黎等: "改良彗星试验检测紫外线照射致淋巴细胞DNA损伤", 《中国公共卫生》 *
熊何健等: "紫外辐射诱导牡蛎细胞DNA损伤的单细胞凝胶电泳检测", 《云南民族大学学报(自然科学版)》 *
王睿等: "紫外辐射弓}起DNA损伤的修复", 《中国组织工程研究与临床康复》 *

Also Published As

Publication number Publication date
US20150219619A1 (en) 2015-08-06
WO2014041340A1 (en) 2014-03-20
EP2895853A1 (en) 2015-07-22
JP2015529077A (ja) 2015-10-05
GB201216174D0 (en) 2012-10-24
IN2015DN02685A (https=) 2015-09-04

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