CN104749226A - Method for determining imatinib mesylate content by potentiometric titration - Google Patents
Method for determining imatinib mesylate content by potentiometric titration Download PDFInfo
- Publication number
- CN104749226A CN104749226A CN201310725071.3A CN201310725071A CN104749226A CN 104749226 A CN104749226 A CN 104749226A CN 201310725071 A CN201310725071 A CN 201310725071A CN 104749226 A CN104749226 A CN 104749226A
- Authority
- CN
- China
- Prior art keywords
- imatinib mesylate
- titration
- content
- mesylate content
- determining
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Abstract
The invention discloses a method for determining imatinib mesylate content by potentiometric titration, which comprises the following steps: A)weighing 0.1g imatinib mesylate, adding 5ml acetate acid gracial for dissolving, adding 50ml acetic anhydride or formic anhydride or propionic anhydride; B)using 0.001mol/L-0.5mol/L perchloric acid titration solution for titration, calculating content of imatinib mesylate content; and C)using blank test for correcting the imatinib mesylate content. By taking a nonaqueous solvent as a titration medium, organic compound solubility can be increased, chemical property of the substance is changed, complete titration which can not be carried out in water can be smoothly performed, so that titration analysis application scope is enlarged, method is simple and fast, the analysis sensitivity is high, and the result is accurate and reliable.
Description
Technical field
The present invention relates to a kind of assay method of medicament contg, be specifically related to a kind of method of potentiometric determination imatinib mesylate content.
Background technology
Imatinib mesylate is used for the treatment of the chronic phase patient after the failure of chronic myelocytic leukemia (CML) CML-BC, accelerated period or alpha-interferon therapy; Can not excision or occur transfer malignant gastrointestinal mesenchymal neoplasm (GIST) patient.
Chemical structural formula:
Molecular formula: C
29h
31n
7oCH
3sO
3h 589.71
Molecular weight: 589.71
Existing titration method metrical error is large, produces larger impact to quality control.
Summary of the invention
The object of the invention is the deficiency existed for prior art, provide a kind of method of potentiometric determination imatinib mesylate content, filter out best Titration Conditions.
The object of the invention is to be realized by following steps:
A. take imatinib mesylate 0.1g, add glacial acetic acid 5ml and dissolve, add aceticanhydride or formic anhydride or propionic andydride 50ml;
B. fixed with the perchloric acid titration drop of 0.001mol/L ~ 0.5mol/L, calculate imatinib mesylate content;
C. imatinib mesylate content is corrected with blank test.
In said method, perchloric acid titration liquid optium concentration is 0.lmol/L.
Compared with prior art the present invention has following obvious advantage: using non-aqueous solvent as titration media, the solubleness of organic compound can not only be increased, and the chemical property of material can be changed, enable to carry out titration completely in water to carry out smoothly, thus expand titrimetric range of application, method simple and fast, sensitivity for analysis is high, and result accurately and reliably.
Embodiment
Below in conjunction with embodiment, the present invention is described in further detail:
Get this product and be about 0.1g, accurately weighed, after adding glacial acetic acid 5ml dissolving, add aceticanhydride 50ml, according to potentiometric titration (Chinese Pharmacopoeia version in 2010 two annex VII A), with perchloric acid titration liquid (0.lmol/L) titration, and titration results blank test is corrected.Every 1ml perchloric acid titration liquid (0.lmol/L) is equivalent to the C of 14.74mg
29h
31n
7oCH
3sO
3h.
Claims (1)
1. by a method for potentiometric determination imatinib mesylate content, it is characterized in that, realized by following steps:
Take imatinib mesylate 0.1g, add glacial acetic acid 5ml and dissolve, add aceticanhydride or formic anhydride or propionic andydride 50ml;
Fixed with the perchloric acid titration drop of 0.001mol/L ~ 0.5mol/L, calculate imatinib mesylate content;
Imatinib mesylate content is corrected with blank test.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201310725071.3A CN104749226A (en) | 2013-12-25 | 2013-12-25 | Method for determining imatinib mesylate content by potentiometric titration |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201310725071.3A CN104749226A (en) | 2013-12-25 | 2013-12-25 | Method for determining imatinib mesylate content by potentiometric titration |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN104749226A true CN104749226A (en) | 2015-07-01 |
Family
ID=53589222
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201310725071.3A Pending CN104749226A (en) | 2013-12-25 | 2013-12-25 | Method for determining imatinib mesylate content by potentiometric titration |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN104749226A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103575791A (en) * | 2013-11-18 | 2014-02-12 | 南京艾德凯腾生物医药有限责任公司 | Method for measuring content of crude tapentadol hydrochloride drug |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1501485B1 (en) * | 2002-04-23 | 2007-09-26 | Novartis AG | High drug load tablet |
| CN102040587A (en) * | 2009-10-26 | 2011-05-04 | 韩南银 | Preparation method of imatinib mesylate |
| CN102661988A (en) * | 2012-05-09 | 2012-09-12 | 南京艾德凯腾生物医药有限责任公司 | Method for testing content of imatinib mesylate raw material medicine |
| CN103197081A (en) * | 2013-04-17 | 2013-07-10 | 无锡优创生物科技有限公司 | Protein chip and preparation and detection method thereof |
-
2013
- 2013-12-25 CN CN201310725071.3A patent/CN104749226A/en active Pending
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1501485B1 (en) * | 2002-04-23 | 2007-09-26 | Novartis AG | High drug load tablet |
| CN102040587A (en) * | 2009-10-26 | 2011-05-04 | 韩南银 | Preparation method of imatinib mesylate |
| CN102661988A (en) * | 2012-05-09 | 2012-09-12 | 南京艾德凯腾生物医药有限责任公司 | Method for testing content of imatinib mesylate raw material medicine |
| CN103197081A (en) * | 2013-04-17 | 2013-07-10 | 无锡优创生物科技有限公司 | Protein chip and preparation and detection method thereof |
Non-Patent Citations (1)
| Title |
|---|
| 赵海桥等: "HPLC法测定甲磺酸伊马替尼片的含量", 《齐鲁药事》 * |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103575791A (en) * | 2013-11-18 | 2014-02-12 | 南京艾德凯腾生物医药有限责任公司 | Method for measuring content of crude tapentadol hydrochloride drug |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN104535689B (en) | The gas-chromatography detection method of 1-METHYLPYRROLIDONE content in a kind of electrodes of lithium-ion batteries | |
| CN104749226A (en) | Method for determining imatinib mesylate content by potentiometric titration | |
| CN105424829A (en) | Detecting method for various acid drugs in sediment of water body | |
| CN104807939B (en) | Detect benzoic method in food | |
| CN104502520B (en) | The assay method of p-methyl benzenesulfonic acid content in a kind of butyl acrylate reactor | |
| EP3564662B1 (en) | Method for quantitative analysis of monomers in polyimide film | |
| CN103728389B (en) | HPLC method is used to measure the method for butyric acid and sodium butyrate | |
| CN106496641A (en) | A kind of preparation method and its usage of daiamid/rare-earth fluorescent blotting membrane | |
| CN103494850B (en) | Process for extracting and purifying total organic acid of aralia cordata | |
| CN105510460A (en) | Method for quantitative detection of gluconic acids and glucono lactone | |
| CN104165942A (en) | Method for detecting content of vinpocetine compound | |
| CN104458967B (en) | The assay method of DBD contents in a kind of rubber chemistry peptizer | |
| CN104807912B (en) | Detect the method for sorbic acid in food | |
| CN103884789A (en) | Method for rapidly determining polysaccharide peptide in lucid ganoderma product | |
| CN103760267B (en) | High performance liquid chromatography detection method for creatine phosphate disodium salt content and impurities | |
| CN105651909A (en) | Method for determining vitamin A in premix feed | |
| CN104614455A (en) | Content detection method of alprostadil injection | |
| CN102661988A (en) | Method for testing content of imatinib mesylate raw material medicine | |
| CN104316520A (en) | Detection method of trace aluminum in tea polyphenol | |
| CN102419324A (en) | Olaquindox flow injection molecular imprinting-chemiluminescence on-line coupled detection method | |
| CN103822979B (en) | The assay method of nicotine content in a kind of tobacco extract | |
| LI et al. | Determination of voriconazole in human plasma by HPLC | |
| CN102353743A (en) | Method for measuring content of oryzanol in rice bran oil by high performance liquid chromatography (HPLC) | |
| CN105954455A (en) | Docetaxel content determining method | |
| CN105699517A (en) | High performance liquid chromatography detection method for content of altrenogest |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| WD01 | Invention patent application deemed withdrawn after publication |
Application publication date: 20150701 |
|
| WD01 | Invention patent application deemed withdrawn after publication |