CN104740328A - Preparation for treating chronic pharyngitis and with functions of moistening lung and reducing swelling and preparation method - Google Patents
Preparation for treating chronic pharyngitis and with functions of moistening lung and reducing swelling and preparation method Download PDFInfo
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Abstract
The invention discloses a preparation for treating chronic pharyngitis and with the functions of moistening the lung and reducing swelling. The preparation is mainly prepared from the following active pharmaceutical ingredients in parts by weight: 9-17 parts of honeysuckle flower, 9-14 parts of blackend swallowwort root, 13-18 parts of herb of denseflower bulbophyllum, 11-16 parts of resin of diversifolious poplar, 13-17 parts of peppermint, 11-15 parts of common anemarrhena rhizome, 10-16 parts of pseudobulb of fimbriate calanthe, 12-15 parts of mulberry leaf, 12-17 parts of creeping woodsorrel herb, 12-15 parts of medicinal fatheadtree, 9-13 parts of herb of smallflower galinsoga, 10-16 parts of powder on the surface of a dried persimmon, 11-17 parts of herb of prostrate wedelia, 8-16 parts of leaf of acuminate violet, 13-20 parts of Indian buead and 10-15 parts of amur linden. Through summary of the clinical practice for many years, the preparation has the functions of clearing away heat and toxic materials and relieving swelling and pain, has obvious curative effects and treats both symptoms and root causes.
Description
Technical field
The present invention relates to traditional Chinese medicine field, particularly relate to chronic pharyngitis lung moistening detumescence preparation and preparation method.
Background technology
Chronic pharyngitis is under pharynx mucosa, mucosa and adenoid chronic inflammatory disease.Diffusivity pharyngeal inflammation is often a part for upper respiratory tract chronic inflammatory disease; Limitation pharyngeal inflammation mostly then is pharynx lymphoid tissue inflammation.Primary disease is common in clinical, and the course of disease is long, the easy recurrent exerbation of symptom.Chronic pharyngitis is more common in adult, and child also can occur.General Symptoms is all not obvious, based on local symptom.Various chronic pharyngitis symptom is roughly similar and varied, as pharyngeal sense of discomfort, foreign body sensation, pharyngeal secretions not easily bring up, pharyngeal gargalesthesia, burn feeling, dry sensation or excitement, also can have hypodynia sense.Because pharynx rear wall is usually because pharyngeal chronic inflammatory disease causes more sticky secretions to adhere to, and cause mouth breathing at night due to nose, nasal sinuses, nasopharynx pathological changes, when morning of being everlasting rises, occur irritable cough and nauseating.Frequently swallow because foreign body in pharynx sense can show as.Pharyngeal secretions few and not easily expectoration person often show as habitually dry cough and expectoration action of clearing one's throat, pharyngeal mucosa hemorrhage can be caused if firmly cough or clear one's throat, cause in secretions and be with blood.
Publication No. CN 104338011 A(application number 201310330828.9) Chinese patent literature disclose a kind of Chinese medicine for the treatment of chronic pharyngitis, effectively can solve the medication problem for the treatment of chronic pharyngitis, its technical scheme solved adopts following material medicine to form: Fructus Forsythiae 2-7 gram, Rhizoma Atractylodis Macrocephalae 6-10 gram, Squama Manis 5-15 gram, Cortex Magnoliae Officinalis 8-16 gram, Mass Galla chinesis et camelliae Fermentata 7-16 gram, Radix Platycodonis 3-6 gram, Cortex Eucommiae 5-10 gram, Rhizoma Paridis 6-12 gram, Rhizoma Polygonati Odorati 5-10 gram, Radix Scrophulariae 8-16 gram, Fructus Corni 6-12 gram, Auricularia Sophorae 2-5 gram, Fructus Crataegi charcoal 12-16 gram.Publication No. CN 102166298 A(application number 201110082694.4) Chinese patent literature disclose a kind of chronic pharyngitis preparation, described chronic pharyngitis preparation comprises the component of following weight portion: Flos Lonicerae 15-45 part, Radix Ophiopogonis 15-45 part, Radix Glycyrrhizae 3-7 part, Semen Sterculiae Lychnophorae 3-7 part, Semen Oroxyli 5-15 part.Publication No. CN 104083616 A(application number 201410363608.0) Chinese patent literature disclose a kind of buccal tablet for the treatment of chronic pharyngitis, it is made according to the raw material by following weight proportion: Semen Sterculiae Lychnophorae 20-40, Fructus Momordicae 15-30, Mel 5-15, Herba Menthae 5-10, Bulbus Fritillariae Cirrhosae 10-20, Radix Ophiopogonis 5-10, Radix Platycodonis 5-15, Flos Lonicerae 5-10, Fructus Mume 5-15, Radix Glycyrrhizae 10-20 make.
Current treatment chronic pharyngitis there is no specific medicament, Western medicine many employings antibiotic, and long-term taking easily develops immunity to drugs and side effect, and the Coryza Treated by Syndrome Differentiation theory of the traditional Chinese medical science, be more applicable for chronic pharyngitis, but part Chinese medicine formula effect is not remarkable, so answer strengthening research, improve curative effect.
Summary of the invention
For the problem of prior art, the object of this invention is to provide a kind of Be very effective, take the wide chronic pharyngitis lung moistening detumescence preparation of safe and applicable and preparation method.
Technical scheme of the present invention is:
Chronic pharyngitis lung moistening detumescence preparation, is prepared from primarily of following bulk drugs, is mass parts: Flos Lonicerae 9-17; Radix Cynanchi Atrati 9-14; Herba Bulbophylli Odoratissim 13-18; Resina Populi Diversifoliae 11-16; Herba Menthae 13-17; Rhizoma Anemarrhenae 11-15; Pseudobulbus Calanthes fimbriatae 10-16; Folium Mori 12-15; Herba Oxalidis Corniculatae 12-17; Lignum et Radix Naucleae 12-15; Herba galinsogae parviflorae 9-13; Mannosum Kaki 10-16; Herba Wedeliae Prostratae 11-17; Folium Violae Acuminatae 8-16; Poria 13-20; Tilia amurensis 10-15.
Preferred version is, Flos Lonicerae 11-15; Radix Cynanchi Atrati 10-13; Herba Bulbophylli Odoratissim 14-17; Resina Populi Diversifoliae 12-15; Herba Menthae 14-16; Rhizoma Anemarrhenae 12-14; Pseudobulbus Calanthes fimbriatae 12-14; Folium Mori 13-14; Herba Oxalidis Corniculatae 13-16; Lignum et Radix Naucleae 13-14; Herba galinsogae parviflorae 10-12; Mannosum Kaki 12-14; Herba Wedeliae Prostratae 13-15; Folium Violae Acuminatae 10-14; Poria 15-18; Tilia amurensis 11-14.
More preferably: Flos Lonicerae 13; Radix Cynanchi Atrati 11.5; Herba Bulbophylli Odoratissim 15.5; Resina Populi Diversifoliae 13.5; Herba Menthae 15; The Rhizoma Anemarrhenae 13; Pseudobulbus Calanthes fimbriatae 13; Folium Mori 13.5; Herba Oxalidis Corniculatae 14.5; Lignum et Radix Naucleae 13.5; Herba galinsogae parviflorae 11; Mannosum Kaki 13; Herba Wedeliae Prostratae 14; Folium Violae Acuminatae 12; Poria 16.5; Tilia amurensis 12.5.
Described chronic pharyngitis lung moistening detumescence preparation, be made into pharmaceutically acceptable decoction, its preparation method is:
(1) extracting honeysuckle, Herba Menthae, Folium Mori, Folium Violae Acuminatae and tilia amurensis removing impurity, add water clean, chopping is placed in container, adds Mel and wine is mixed thoroughly, and slow fire heats, constantly stir-fry to micro-Jiao, take out, dry in the air cool;
(2) get Resina Populi Diversifoliae to clean, be placed in frying pan, the micro-stir-fry of little fire, to smoldering, is taken out and is put into rice vinegar dipping 4-8 minute (preferred: to flood 6 minutes), repeat twice, take out, dry;
(3) Herba Bulbophylli Odoratissim, Herba Oxalidis Corniculatae, Herba galinsogae parviflorae and Herba Wedeliae Prostratae are picked up clean impurity, be cut into thread, add 80% alcohol reflux three times, it is (preferred: the time is 70-80 minute that each extraction time is 60-90 minute; Be more preferably: the time is 75 minutes), merge extractive liquid, decompression and solvent recovery, to without alcohol taste, filter and collect filtrate;
(4) after Radix Cynanchi Atrati, the Rhizoma Anemarrhenae, pseudobulbus Calanthes fimbriatae, Lignum et Radix Naucleae and Poria being cleaned remove impurity, be placed in marmite, add boiled crude drug quality 5-7 water doubly (preferred: the water adding boiled crude drug quality 6 times) to decoct, big fire is heated to boiling, turns little fire and decocts 30-46 minute (preferably: little fire decocts 34-42 minute; Be more preferably: little fire decocts 38 minutes), filter and collect filtrate;
(5) Mannosum Kaki and step (1) (2) made crude drug are pulverized, mix homogeneously with step (3) (4) gained filtrate, obtain decoction.
The preparation method of described chronic pharyngitis lung moistening detumescence preparation decoction, the amount that step (3) adds 80% ethanol is that the 3-6 of crude drug quality is doubly (preferred: the amount adding 80% ethanol is 4-5 times of crude drug quality; Be more preferably: the amount adding 80% ethanol is 4.5 times of crude drug quality).
Described chronic pharyngitis lung moistening detumescence preparation, be made into pharmaceutically acceptable powder, its preparation method is:
(1) extracting honeysuckle, Herba Menthae, Folium Mori, Folium Violae Acuminatae and tilia amurensis removing impurity, add water clean, chopping is placed in container, adds Mel and wine is mixed thoroughly, and slow fire heats, constantly stir-fry to micro-Jiao, take out, dry in the air cool;
(2) get Resina Populi Diversifoliae to clean, be placed in frying pan, the micro-stir-fry of little fire, to smoldering, is taken out and is put into rice vinegar dipping 4-8 minute (preferred: to flood 6 minutes), repeat twice, take out, dry;
(3) Herba Bulbophylli Odoratissim, Herba Oxalidis Corniculatae, Herba galinsogae parviflorae and Herba Wedeliae Prostratae are picked up clean impurity, are cut into thread, add 80% alcohol reflux three times of crude drug quality 4.5 times, each extraction time be 60-90 minute (preferred: the time is 70-80 minute; Be more preferably: the time is 75 minutes), merge extractive liquid, decompression and solvent recovery, to without alcohol taste, filter and collect filtrate;
(4) after Radix Cynanchi Atrati, the Rhizoma Anemarrhenae, pseudobulbus Calanthes fimbriatae, Lignum et Radix Naucleae and Poria being cleaned remove impurity, be placed in marmite, add boiled crude drug quality 5-7 water doubly (preferred: the water adding boiled crude drug quality 6 times) to decoct, big fire is heated to boiling, turns little fire and decocts 30-46 minute (preferably: little fire decocts 34-42 minute; Be more preferably: little fire decocts 38 minutes), filter and collect filtrate;
(5) blend step (3) (4) gained filtrate, pulverizes and sieves with step (1) (2) gained crude drug after spraying dry, obtains powder together with Mannosum Kaki.
The preparation method of described chronic pharyngitis lung moistening detumescence preparation powder, it is (preferred: to pulverize 120-160 mesh sieve that step (5) pulverized 100-180 mesh sieve; Be more preferably: pulverized 140 mesh sieves).
Described chronic pharyngitis lung moistening detumescence preparation, be made into pharmaceutically acceptable granule, its preparation method is:
(1) extracting honeysuckle, Herba Menthae, Folium Mori, Folium Violae Acuminatae and tilia amurensis removing impurity, add water clean, chopping is placed in container, adds Mel and wine is mixed thoroughly, and slow fire heats, constantly stir-fry to micro-Jiao, take out, dry in the air cool;
(2) get Resina Populi Diversifoliae to clean, be placed in frying pan, the micro-stir-fry of little fire, to smoldering, is taken out and is put into rice vinegar dipping 4-8 minute (preferred: to flood 6 minutes), repeat twice, take out, dry;
(3) Herba Bulbophylli Odoratissim, Herba Oxalidis Corniculatae, Herba galinsogae parviflorae and Herba Wedeliae Prostratae are picked up clean impurity, are cut into thread, add 80% alcohol reflux three times of crude drug quality 4.5 times, each extraction time be 60-90 minute (preferred: the time is 70-80 minute; Be more preferably: the time is 75 minutes), merge extractive liquid, decompression and solvent recovery, to without alcohol taste, filter and collect filtrate;
(4) after Radix Cynanchi Atrati, the Rhizoma Anemarrhenae, pseudobulbus Calanthes fimbriatae, Lignum et Radix Naucleae and Poria being cleaned remove impurity, be placed in marmite, add boiled crude drug quality 5-7 water doubly (preferred: the water adding boiled crude drug quality 6 times) to decoct, big fire is heated to boiling, turns little fire and decocts 30-46 minute (preferably: little fire decocts 34-42 minute; Be more preferably: little fire decocts 38 minutes), filter and collect filtrate;
(5) blend step (3) (4) gained filtrate, is evaporated to thick paste, is pulverized by Mannosum Kaki, be added in thick paste, dry, pulverize, granulate, pack and obtain granule together with step (1) (2) made crude drug.
The preparation method of described chronic pharyngitis lung moistening detumescence preparation granules agent, step (5) baking temperature is 60-80 DEG C (preferred: baking temperature is 70 DEG C).
Described chronic pharyngitis lung moistening detumescence preparation, be made into pharmaceutically acceptable unguentum, its preparation method is:
(1) extracting honeysuckle, Herba Menthae, Folium Mori, Folium Violae Acuminatae and tilia amurensis removing impurity, add water clean, chopping is placed in container, adds Mel and wine is mixed thoroughly, and slow fire heats, constantly stir-fry to micro-Jiao, take out, dry in the air cool;
(2) get Resina Populi Diversifoliae to clean, be placed in frying pan, the micro-stir-fry of little fire, to smoldering, is taken out and is put into rice vinegar dipping 4-8 minute (preferred: to flood 6 minutes), repeat twice, take out, dry;
(3) Herba Bulbophylli Odoratissim, Herba Oxalidis Corniculatae, Herba galinsogae parviflorae and Herba Wedeliae Prostratae are picked up clean impurity, are cut into thread, add 80% alcohol reflux three times of crude drug quality 4.5 times, each extraction time be 60-90 minute (preferred: the time is 70-80 minute; Be more preferably: the time is 75 minutes), merge extractive liquid, decompression and solvent recovery, to without alcohol taste, filter and collect filtrate;
(4) after Radix Cynanchi Atrati, the Rhizoma Anemarrhenae, pseudobulbus Calanthes fimbriatae, Lignum et Radix Naucleae and Poria being cleaned remove impurity, be placed in marmite, add boiled crude drug quality 5-7 water doubly (preferred: the water adding boiled crude drug quality 6 times) and decoct, big fire is heated to boiling, turn little fire to decoct, filter and collect filtrate;
(5) blend step (3) (4) gained filtrate, is evaporated to thick paste, Mannosum Kaki was pulverized 120 mesh sieves together with step (1) (2) made crude drug, is added in thick paste, stirs, obtain unguentum.
The preparation method of described chronic pharyngitis lung moistening detumescence preparation unguentum, step (4) turns little fire and decocts 24-36 minute (preferably: little fire decocts 28-32 minute; Be more preferably: little fire decocts 30 minutes).
Chronic pharyngitis lung moistening detumescence pharmaceutical formulation science provided by the invention, preparation method is simple.In addition, its excellent part also shows:
1, products obtained therefrom of the present invention, therapeutic effect is good, and cure rate is high, effectively can reduce relapse rate;
2, this formula is summed up through clinical practice for many years and is formed, and has effect of heat-clearing and toxic substances removing, reducing swelling and alleviating pain;
3, Chinese crude drug selected by the present invention, takes safety and has no adverse reaction, also can strengthen patient immune function.
Detailed description of the invention
Describe technical scheme of the present invention in detail below in conjunction with embodiment and experimental example, but protection domain is not limited thereto.
embodiment 1chronic pharyngitis lung moistening detumescence preparation, is prepared from (every part of 10g) primarily of following bulk drugs: Flos Lonicerae 9 parts, Radix Cynanchi Atrati 9 parts, Herba Bulbophylli Odoratissim 13 parts, Resina Populi Diversifoliae 11 parts, Herba Menthae 13 parts, the Rhizoma Anemarrhenae 11 parts, pseudobulbus Calanthes fimbriatae 10 parts, 12 parts, Folium Mori, Herba Oxalidis Corniculatae 12 parts, Lignum et Radix Naucleae 12 parts, Herba galinsogae parviflorae 9 parts, Mannosum Kaki 10 parts, Herba Wedeliae Prostratae 11 parts, Folium Violae Acuminatae 8 parts, 13 parts, Poria, tilia amurensis 10 parts.The preparation method of above-mentioned chronic pharyngitis lung moistening detumescence preparation decoction is:
(1) extracting honeysuckle, Herba Menthae, Folium Mori, Folium Violae Acuminatae and tilia amurensis removing impurity, add water clean, chopping is placed in container, adds Mel and wine is mixed thoroughly, and slow fire heats, constantly stir-fry to micro-Jiao, take out, dry in the air cool;
(2) get Resina Populi Diversifoliae to clean, be placed in frying pan, the micro-stir-fry of little fire, to smoldering, is taken out and is put into rice vinegar dipping 6 minutes, repeat twice, take out, dry;
(3) Herba Bulbophylli Odoratissim, Herba Oxalidis Corniculatae, Herba galinsogae parviflorae and Herba Wedeliae Prostratae are picked up clean impurity, be cut into thread, add 80% alcohol reflux three times of crude drug quality 4.5 times, each extraction time is 75 minutes, merge extractive liquid, decompression and solvent recovery, to without alcohol taste, filter and collect filtrate;
(4) after Radix Cynanchi Atrati, the Rhizoma Anemarrhenae, pseudobulbus Calanthes fimbriatae, Lignum et Radix Naucleae and Poria being cleaned remove impurity, be placed in marmite, add the soak by water of boiled crude drug quality 6 times, big fire is heated to boiling, turns little fire and decocts 38 minutes, filter and collect filtrate;
(5) Mannosum Kaki and step (1) (2) made crude drug are pulverized, mix homogeneously with step (3) (4) gained filtrate, obtain decoction.
embodiment 2chronic pharyngitis lung moistening detumescence preparation, is prepared from (every part of 10g) primarily of following bulk drugs: Flos Lonicerae 17 parts, Radix Cynanchi Atrati 14 parts, Herba Bulbophylli Odoratissim 18 parts, Resina Populi Diversifoliae 16 parts, Herba Menthae 17 parts, the Rhizoma Anemarrhenae 15 parts, pseudobulbus Calanthes fimbriatae 16 parts, 15 parts, Folium Mori, Herba Oxalidis Corniculatae 17 parts, Lignum et Radix Naucleae 15 parts, Herba galinsogae parviflorae 13 parts, Mannosum Kaki 16 parts, Herba Wedeliae Prostratae 17 parts, Folium Violae Acuminatae 16 parts, 20 parts, Poria, tilia amurensis 15 parts.The preparation method of above-mentioned chronic pharyngitis lung moistening detumescence preparation powder is:
(1) extracting honeysuckle, Herba Menthae, Folium Mori, Folium Violae Acuminatae and tilia amurensis removing impurity, add water clean, chopping is placed in container, adds Mel and wine is mixed thoroughly, and slow fire heats, constantly stir-fry to micro-Jiao, take out, dry in the air cool;
(2) get Resina Populi Diversifoliae to clean, be placed in frying pan, the micro-stir-fry of little fire, to smoldering, is taken out and is put into rice vinegar dipping 6 minutes, repeat twice, take out, dry;
(3) Herba Bulbophylli Odoratissim, Herba Oxalidis Corniculatae, Herba galinsogae parviflorae and Herba Wedeliae Prostratae are picked up clean impurity, be cut into thread, add 80% alcohol reflux three times of crude drug quality 4.5 times, each extraction time is 75 minutes, merge extractive liquid, decompression and solvent recovery, to without alcohol taste, filter and collect filtrate;
(4) after Radix Cynanchi Atrati, the Rhizoma Anemarrhenae, pseudobulbus Calanthes fimbriatae, Lignum et Radix Naucleae and Poria being cleaned remove impurity, be placed in marmite, add the soak by water of boiled crude drug quality 6 times, big fire is heated to boiling, turns little fire and decocts 38 minutes, filter and collect filtrate;
(5) blend step (3) (4) gained filtrate, pulverized 140 mesh sieves with step (1) (2) gained crude drug after spraying dry, obtained powder together with Mannosum Kaki.
Model case: xxx, male, 49 years old.Main suit: throat discomfort 1 year, flu increases the weight of, throat's pain; Medical history: patient is before one week, and because there was an abrupt change in weather, health is caught a cold and caused flu, and cough is more than, has yellow sputum, after infusion treatment, flu takes a turn for the better, but throat still has discomfort, has foreign body sensation, that coughs does not go out, and with nausea, checks further through doctor, is diagnosed as chronic pharyngitis.
Take this example gained powder, each 4-6g, warm boiled water, one day twice, within ten days, be a course for the treatment of, after patient takes a course for the treatment of, throat swells and ache remission, and cough, expectoration alleviate, hold on and take two courses for the treatment of, uncomfortable disease is all eliminated, and patient fully recovers, and to follow up a case by regular visits in 1 year not repeatedly.
embodiment 3chronic pharyngitis lung moistening detumescence preparation, is prepared from (every part of 10g) primarily of following bulk drugs: Flos Lonicerae 11 parts, Radix Cynanchi Atrati 10 parts, Herba Bulbophylli Odoratissim 14 parts, Resina Populi Diversifoliae 12 parts, Herba Menthae 14 parts, the Rhizoma Anemarrhenae 12 parts, pseudobulbus Calanthes fimbriatae 12 parts, 13 parts, Folium Mori, Herba Oxalidis Corniculatae 13 parts, Lignum et Radix Naucleae 13 parts, Herba galinsogae parviflorae 10 parts, Mannosum Kaki 12 parts, Herba Wedeliae Prostratae 13 parts, Folium Violae Acuminatae 10 parts, 15 parts, Poria, tilia amurensis 11 parts.The preparation method of above-mentioned chronic pharyngitis lung moistening detumescence preparation granules agent is:
(1) extracting honeysuckle, Herba Menthae, Folium Mori, Folium Violae Acuminatae and tilia amurensis removing impurity, add water clean, chopping is placed in container, adds Mel and wine is mixed thoroughly, and slow fire heats, constantly stir-fry to micro-Jiao, take out, dry in the air cool;
(2) get Resina Populi Diversifoliae to clean, be placed in frying pan, the micro-stir-fry of little fire, to smoldering, is taken out and is put into rice vinegar dipping 6 minutes, repeat twice, take out, dry;
(3) Herba Bulbophylli Odoratissim, Herba Oxalidis Corniculatae, Herba galinsogae parviflorae and Herba Wedeliae Prostratae are picked up clean impurity, be cut into thread, add 80% alcohol reflux three times of crude drug quality 4.5 times, each extraction time is 75 minutes, merge extractive liquid, decompression and solvent recovery, to without alcohol taste, filter and collect filtrate;
(4) after Radix Cynanchi Atrati, the Rhizoma Anemarrhenae, pseudobulbus Calanthes fimbriatae, Lignum et Radix Naucleae and Poria being cleaned remove impurity, be placed in marmite, add the soak by water of boiled crude drug quality 6 times, big fire is heated to boiling, turns little fire and decocts 38 minutes, filter and collect filtrate;
(5) blend step (3) (4) gained filtrate, is evaporated to thick paste, is pulverized by Mannosum Kaki, is added in thick paste, dry, pulverize, granulate, pack and obtain granule under 70 DEG C of environment together with step (1) (2) made crude drug.
Model case: xxx, women, 58 years old.Medical history: patient must have chronic pharyngitis 10 years, and throughout the year smoking, pharyngeal drying, to itch, paroxysmal cough, voice signal to noise ratio is more hoarse, get up even more serious in the morning, and activity just causes cough a little, has yellow sputum, sputum mixed with blood silk once in a while, advise through household, prepare quitting tobacco dependency, seek method treatment chronic pharyngitis.
Recommend to take this example gained granule, each 4-6g, warm boiled water through people, one day twice, within ten days, be a course for the treatment of, patient takes two courses for the treatment of, pharyngeal discomfort obviously alleviates, amount of expectoration reduces, after continuing to take two courses for the treatment of, pharyngeal smooth and easy, speak clear, on inspection, patient fully recovers, and the mental status is clearly better.
embodiment 4chronic pharyngitis lung moistening detumescence preparation, is prepared from (every part of 10g) primarily of following bulk drugs: Flos Lonicerae 15 parts, Radix Cynanchi Atrati 13 parts, Herba Bulbophylli Odoratissim 17 parts, Resina Populi Diversifoliae 15 parts, Herba Menthae 16 parts, the Rhizoma Anemarrhenae 14 parts, pseudobulbus Calanthes fimbriatae 14 parts, 14 parts, Folium Mori, Herba Oxalidis Corniculatae 16 parts, Lignum et Radix Naucleae 14 parts, Herba galinsogae parviflorae 12 parts, Mannosum Kaki 14 parts, Herba Wedeliae Prostratae 15 parts, Folium Violae Acuminatae 14 parts, 18 parts, Poria, tilia amurensis 14 parts.The preparation method of above-mentioned chronic pharyngitis lung moistening detumescence preparation unguentum is:
(1) extracting honeysuckle, Herba Menthae, Folium Mori, Folium Violae Acuminatae and tilia amurensis removing impurity, add water clean, chopping is placed in container, adds Mel and wine is mixed thoroughly, and slow fire heats, constantly stir-fry to micro-Jiao, take out, dry in the air cool;
(2) get Resina Populi Diversifoliae to clean, be placed in frying pan, the micro-stir-fry of little fire, to smoldering, is taken out and is put into rice vinegar dipping 6 minutes, repeat twice, take out, dry;
(3) Herba Bulbophylli Odoratissim, Herba Oxalidis Corniculatae, Herba galinsogae parviflorae and Herba Wedeliae Prostratae are picked up clean impurity, be cut into thread, add 80% alcohol reflux three times of crude drug quality 4.5 times, each extraction time is 75 minutes, merge extractive liquid, decompression and solvent recovery, to without alcohol taste, filter and collect filtrate;
(4) after Radix Cynanchi Atrati, the Rhizoma Anemarrhenae, pseudobulbus Calanthes fimbriatae, Lignum et Radix Naucleae and Poria being cleaned remove impurity, be placed in marmite, add the soak by water of boiled crude drug quality 6 times, big fire is heated to boiling, turns little fire and decocts 30 minutes, filter and collect filtrate;
(5) blend step (3) (4) gained filtrate, is evaporated to thick paste, Mannosum Kaki was pulverized 120 mesh sieves together with step (1) (2) made crude drug, is added in thick paste, stirs, obtain unguentum.
Model case: xxx, male, 36 years old.Main suit: laryngopharynx swelling and pain, dysphagia; Medical history: patient is a teacher, in nearly one week, worries about and stays up late excessively, cause depletion fire syndrome going up, lassitude, with laryngopharynx swelling and pain, the symptom of dysphagia, takes pathogenic fire reducing class medicine certainly, effect is very remarkable, and the state of an illness has and increases the weight of sign, to hospital diagnosis, is diagnosed as chronic pharyngitis.
Accept doctor advised, use traditional Chinese medical science expectant treatment, take this example gained unguentum, each 6-10g, warm boiled water, one day twice, within ten days, be a course for the treatment of, after patient takes one week, the mental status promotes, laryngopharynx swelling and pain disappears, after taking three courses for the treatment of, patient can normal swallow, and uncomfortable disease is all eliminated, in drug withdrawal 1 year, the state of an illness is without recurrence.
embodiment 5chronic pharyngitis lung moistening detumescence preparation, is prepared from (every part of 10g) primarily of following bulk drugs: Flos Lonicerae 13 parts, Radix Cynanchi Atrati 11.5 parts, Herba Bulbophylli Odoratissim 15.5 parts, Resina Populi Diversifoliae 13.5 parts, Herba Menthae 15 parts, the Rhizoma Anemarrhenae 13 parts, pseudobulbus Calanthes fimbriatae 13 parts, 13.5 parts, Folium Mori, Herba Oxalidis Corniculatae 14.5 parts, Lignum et Radix Naucleae 13.5 parts, Herba galinsogae parviflorae 11 parts, Mannosum Kaki 13 parts, Herba Wedeliae Prostratae 14 parts, Folium Violae Acuminatae 12 parts, 16.5 parts, Poria, tilia amurensis 12.5 parts.The preparation method of above-mentioned chronic pharyngitis lung moistening detumescence preparation decoction is:
(1) extracting honeysuckle, Herba Menthae, Folium Mori, Folium Violae Acuminatae and tilia amurensis removing impurity, add water clean, chopping is placed in container, adds Mel and wine is mixed thoroughly, and slow fire heats, constantly stir-fry to micro-Jiao, take out, dry in the air cool;
(2) get Resina Populi Diversifoliae to clean, be placed in frying pan, the micro-stir-fry of little fire, to smoldering, is taken out and is put into rice vinegar dipping 6 minutes, repeat twice, take out, dry;
(3) Herba Bulbophylli Odoratissim, Herba Oxalidis Corniculatae, Herba galinsogae parviflorae and Herba Wedeliae Prostratae are picked up clean impurity, be cut into thread, add 80% alcohol reflux three times of crude drug quality 4.5 times, each extraction time is 75 minutes, merge extractive liquid, decompression and solvent recovery, to without alcohol taste, filter and collect filtrate;
(4) after Radix Cynanchi Atrati, the Rhizoma Anemarrhenae, pseudobulbus Calanthes fimbriatae, Lignum et Radix Naucleae and Poria being cleaned remove impurity, be placed in marmite, add the soak by water of boiled crude drug quality 6 times, big fire is heated to boiling, turns little fire and decocts 38 minutes, filter and collect filtrate;
(5) Mannosum Kaki and step (1) (2) made crude drug are pulverized, mix homogeneously with step (3) (4) gained filtrate, obtain decoction.
The pharmacology of the present invention's main raw material of Chinese medicine used is as follows:
Flos Lonicerae: sweet in the mouth, micro-hardship, cold nature.Have heat-clearing and toxic substances removing, expelling pathogenic factors from the exterior is gone out, effect of stomach function regulating preventing or arresting vomiting, stops up resistance, disorder of stomach-QI, fever and irritability for pathogenic heat.
Radix Cynanchi Atrati: nature and flavor with return through: bitter, becomes, tremble with fear.Return stomach, liver, kidney channel.There is clearing away heat and cooling blood, inducing diuresis for treating stranguria syndrome, effect of detoxification sore treatment.For pathogenic warmth wound battalion heating, fever due to yin deficiency, hectic fever due to YIN-deficiency consumptive fever, puerperal fever due to deficiency of blood, pyretic stranguria, stranguria with blood, swollen ulcer drug.
Herba Bulbophylli Odoratissim: base is former: be the herb of the orchid family Bulbophyllum plant honey flower Bulbophyllum.The property of medicine: sweet, light, cool.Function cures mainly: moistening the lung and resolving phlegm, activating collaterals to relieve pain.Cure mainly pulmonary tuberculosis hemoptysis, chronic tracheitis, chronic pharyngitis, hernia pain, menoxenia, rheumatism is benumbed, traumatic injury, fracture.
Resina Populi Diversifoliae: base is former: in the resin flow of Salicaceae poplar Populus euphratica buries, the product formed afterwards for many years.The property of medicine: bitter, salty, cold.Attach to the lung and stomach meridians.Function cures mainly: heat-clearing and toxic substances removing, resolving phlegm and softening hard masses.Cure mainly laryngopharynx swelling and pain, toothache, ulcerative gingivitis, otitis media, stomachache.
Herba Menthae: acrid in the mouth, cool in nature.There is dispelling wind and heat pathogens, the clear sharp head, sore-throat relieving rash, effect of soothing the liver circulation of qi promoting, for laryngopharynx swelling and pain, headache, stagnation of QI due to depression of the liver.
The Rhizoma Anemarrhenae: nature and flavor: bitter, sweet, cold.Return lung, stomach, kidney channel.There is clearing away heat-fire, nourshing Yin and drynsessmoistening prescription effect.For fever caused by exogenous pathogenic factors, high hot excessive thirst, lung-heat type cough, osteopyrexia and fever, interior-heat is quenched one's thirst, dryness of the intestine constipation.
Pseudobulbus Calanthes fimbriatae: base is former: be pseudobulb and the root of the orchid family Calanthe plant Diffuse Coptosapelta calanthe and sword-like leave calanthe.The property of medicine: pungent, micro-hardship, cool, mild toxicity.Function cures mainly: heat-clearing and toxic substances removing, eliminating stasis to stop pain.Cure mainly laryngopharynx swelling and pain, toothache, epigastric pain, lumbago, arthralgia, traumatic injury, scrofula, venom.
Folium Mori: nature and flavor with return through: sweet, bitter, cold.Return lung, Liver Channel.There is dispelling wind and heat pathogens, clearing away lung-heat and moistening for dryness, effect of liver heat removing and eyesight improving.For anemopyretic cold, lung-heat type cough, dizziness headache, conjunctival congestion is dim-sighted.
Herba Oxalidis Corniculatae: base is former: be the oxalic herb of Oxalidaceae Oxalis plant.The property of medicine: acid, cold.Return liver lung, urinary bladder channel.Function cures mainly: clearing away heat-damp and promoting diuresis, cool the blood dissipate blood stasis, removing toxic substances and promoting subsidence of swelling.Cure mainly diarrhea due to damp-heat, dysentery, jaundice, stranguria, leukorrhagia, hematuria, menoxenia, traumatic injury, laryngopharynx swelling and pain, carbuncle furuncle, erysipelas, eczema, scabies, hemorrhoid, measles, burn and scald, snake bite and insect sting.
Lignum et Radix Naucleae: base is former: be branch, the bark of Rubiaceae Nauclea plant ebony.The property of medicine: Guangzhou army " conventional Chinese herbal medicine handbook ": " bitter, cold." function cures mainly: Guangzhou army " conventional Chinese herbal medicine handbook ": " heat-clearing and toxic substances removing, reducing swelling and alleviating pain.Cure mainly acute tonsillitis, pharyngolaryngitis, mastitis, enteritis, bacillary dysentery, urinary tract infection, cholecystitis, lower limb are burst wound, and tinea pedis infects, your carbuncle of furuncle and phyma, dermatitis and eczema.”
Herba galinsogae parviflorae: be the herb of feverfew Herba galinsogae parviflorae.Nature and flavor: lightly seasoned; Property is put down.Function cures mainly: heat-clearing and toxic substances removing; Relieving cough and asthma; Hemostasis.Main tonsillitis; Pharyngolaryngitis; Icterohepatitis; Cough with asthma; Pulmonary tuberculosis; Nova skin ulcer; Traumatic hemorrhage.
Mannosum Kaki: base is former: the white Refined Mercurous chloride that when fruit for Ebenaceae Diospyros plant Fructus Kaki makes Fructus kaki Siccus, appearance is given birth to.The property of medicine: sweet, cool.Return lung, heart channel.Function cures mainly: nourishing the lung to arrest cough, secretion replenishing and throat moistening, hemostasis.Cure mainly lung-heat type cough, dry pharynx is had sore throat, aphtha of the mouth and tongue, spits blood, and spitting of blood, quenches one's thirst.
Herba Wedeliae Prostratae: base is former: be the herb of Compositae Herbia Wedeliae platymiscium Herba Wedeliae Prostratae.The property of medicine: Guangzhou army " conventional Chinese herbal medicine handbook ": " sweet, light, cool." function cures mainly: clearing away heat and cooling blood, expelling phlegm for arresting cough.Cure mainly flu, throat moth, sore throat, pertussis, dyspnea and cough due to lung-heat, hemoptysis of pulmonary tuberculosis, hypertension, carbuncle furuncle furuncle.
Folium Violae Acuminatae: base is former: be the leaf of Violaceae plant drumsticks common violet.Nature and flavor: light, cold.Function cures mainly: heat-clearing and toxic substances removing, reducing swelling and alleviating pain.Control cough due to lung-heat, treating swelling and pain by traumatic injury, furuncle toxic swelling.
Poria: base is former: be the dry sclerotia of Polyporaceae plant Poria.Nature and flavor with return through: sweet, light, flat.GUIXIN, lung, spleen, kidney channel.There is promoting diuresis to eliminate damp pathogen, spleen invigorating, effect of mind calming.For edema oliguria, phlegm retention vertigo and palpitation, insufficiency of the spleen lack of appetite, have loose bowels in loose stool, irritability, palpitation with fear insomnia.
Tilia amurensis: base is former: be the flower of Tiliaceae plant tilia amurensis.Nature and flavor: pungent; Cool.Function cures mainly: induce sweat; Heat clearing away.Main cold, fever; Stomatitis; Laryngitis; Pyelonephritis.
test example 1the clinical practice of gained chronic pharyngitis lung moistening detumescence preparation (embodiment 5) of the present invention:
Choose crowd: in June, 2013 in December ,-2014, in six hospitals, patient 422 example of chronic pharyngitis is suffered from according to medical case history screening, wherein male 221 example, women 201 example, age 18-62 year, 34.1 ± 0.7 years old mean age, within the course of disease three months-10 years, average course of disease is 2.8 ± 0.4 years, and all patients with clinical manifestations are throat discomfort in various degree, have dryly to itch, sense of obstruction etc., the chemical examinations such as equal promoting the circulation of blood routine, liver function, make a definite diagnosis through Chest X-rays, X-ray film, laryngopharyngeal mirror etc. inspections, discharge the patients such as pulmonary tuberculosis, pulmonary carcinoma, hepatitis.
Before test, patient is divided into two groups at random, experimental group 288 example and matched group 134 routine, two groups in sex, age, the course of disease, the state of an illness etc. without significant difference.Experimental group takes gained decoction of the present invention, each 200-300ml, one day twice, warmly takes, and within ten days, is a course for the treatment of; Matched group takes other conventional medicines (Yanyan slice, LIYANLING PIAN, watermelon crystal or cydiodine etc.).Instruct it to cultivate good living habit, ban on opium-smoking and the opium trade wine, avoid pungent, attention throat, drinks more water, and adheres to suitable physical training simultaneously.Period in a medicine carries out Continuous Observation to two groups of patients, and record symptom and change, follow up a case by regular visits to patient after drug withdrawal, calculates relapse rate.
Curative effect determinate standard: reference literature criterion of therapeutical effect, (1) cures: pharyngeal transference cure, and local sign disappears, and mucosa recovers normal, and person all disappears folliculus; (2) take a turn for the better: pharyngeal symptom and sign alleviate to some extent, and pharyngeal mucosa hyperemia alleviates, pharynx rear wall lymph follicle reduces; (3) invalid: pharyngeal symptom and sign are not improved.
Clinical effectiveness: after the taking medicine of three courses for the treatment of, the therapeutic outcome of two groups is as shown in table 1:
The untoward reaction number of cases of two groups of patients and Follow-up results as shown in table 2:
As shown in Table 1, the cure rate of experimental group is 64.6%, and improvement rate is 33.0%, total effective rate is 97.6%, and the cure rate of matched group is 49.3%, and improvement rate is 31.3%, total effective rate 80.6%, significantly lower than the therapeutic effect of experimental group, illustrate that products obtained therefrom of the present invention is evident in efficacy, cure rate is high, and learnt by table 2, use the patient safety of products obtained therefrom of the present invention to have no side effect, relapse rate is low, effectively can eliminate focus.
The present invention comprises the Flos Lonicerae of heat-clearing and toxic substances removing, Resina Populi Diversifoliae, Herba galinsogae parviflorae, Folium Violae Acuminatae, the Radix Cynanchi Atrati of clearing away heat and cooling blood, Herba Wedeliae Prostratae, the Herba Bulbophylli Odoratissim of moistening the lung and resolving phlegm, the Herba Menthae of sore-throat relieving rash, the nourshing Yin and drynsessmoistening prescription Rhizoma Anemarrhenae, the pseudobulbus Calanthes fimbriatae of eliminating stasis to stop pain, the Folium Mori of clearing away lung-heat and moistening for dryness, the Herba Oxalidis Corniculatae of removing toxic substances and promoting subsidence of swelling, the Lignum et Radix Naucleae of reducing swelling and alleviating pain, the Mannosum Kaki of secretion replenishing and throat moistening, the Poria of promoting diuresis to eliminate damp pathogen, the tilia amurensis of clearing away heat and expelling pathogen in the exterior, multiple medical material synergism, play effect of heat-clearing and toxic substances removing, reducing swelling and alleviating pain altogether, effectively eliminate laryngopharynx swelling and pain, recover mucosa normal.
It should be pointed out that detailed description of the invention is the more representational example of the present invention, obvious technical scheme of the present invention is not limited to above-described embodiment, can also have a lot of distortion.Those of ordinary skill in the art, with the present invention clear and definite disclosed or according to undoubted the obtaining of the written description of file, the claimed scope of this patent all should be thought.
Claims (10)
1. chronic pharyngitis lung moistening detumescence preparation, is characterized in that, be prepared from primarily of following bulk drugs, be mass parts: Flos Lonicerae 9-17; Radix Cynanchi Atrati 9-14; Herba Bulbophylli Odoratissim 13-18; Resina Populi Diversifoliae 11-16; Herba Menthae 13-17; Rhizoma Anemarrhenae 11-15; Pseudobulbus Calanthes fimbriatae 10-16; Folium Mori 12-15; Herba Oxalidis Corniculatae 12-17; Lignum et Radix Naucleae 12-15; Herba galinsogae parviflorae 9-13; Mannosum Kaki 10-16; Herba Wedeliae Prostratae 11-17; Folium Violae Acuminatae 8-16; Poria 13-20; Tilia amurensis 10-15.
2. chronic pharyngitis lung moistening detumescence preparation as claimed in claim 1, is characterized in that, Flos Lonicerae 11-15; Radix Cynanchi Atrati 10-13; Herba Bulbophylli Odoratissim 14-17; Resina Populi Diversifoliae 12-15; Herba Menthae 14-16; Rhizoma Anemarrhenae 12-14; Pseudobulbus Calanthes fimbriatae 12-14; Folium Mori 13-14; Herba Oxalidis Corniculatae 13-16; Lignum et Radix Naucleae 13-14; Herba galinsogae parviflorae 10-12; Mannosum Kaki 12-14; Herba Wedeliae Prostratae 13-15; Folium Violae Acuminatae 10-14; Poria 15-18; Tilia amurensis 11-14(is preferably: Flos Lonicerae 13; Radix Cynanchi Atrati 11.5; Herba Bulbophylli Odoratissim 15.5; Resina Populi Diversifoliae 13.5; Herba Menthae 15; The Rhizoma Anemarrhenae 13; Pseudobulbus Calanthes fimbriatae 13; Folium Mori 13.5; Herba Oxalidis Corniculatae 14.5; Lignum et Radix Naucleae 13.5; Herba galinsogae parviflorae 11; Mannosum Kaki 13; Herba Wedeliae Prostratae 14; Folium Violae Acuminatae 12; Poria 16.5; Tilia amurensis 12.5).
3. the chronic pharyngitis lung moistening detumescence preparation as described in as arbitrary in claim 1-2, it is characterized in that, be made into pharmaceutically acceptable decoction, its preparation method is:
(1) extracting honeysuckle, Herba Menthae, Folium Mori, Folium Violae Acuminatae and tilia amurensis removing impurity, add water clean, chopping is placed in container, adds Mel and wine is mixed thoroughly, and slow fire heats, constantly stir-fry to micro-Jiao, take out, dry in the air cool;
(2) get Resina Populi Diversifoliae to clean, be placed in frying pan, the micro-stir-fry of little fire, to smoldering, is taken out and is put into rice vinegar dipping 4-8 minute (preferred: to flood 6 minutes), repeat twice, take out, dry;
(3) Herba Bulbophylli Odoratissim, Herba Oxalidis Corniculatae, Herba galinsogae parviflorae and Herba Wedeliae Prostratae are picked up clean impurity, be cut into thread, add 80% alcohol reflux three times, it is (preferred: the time is 70-80 minute that each extraction time is 60-90 minute; Be more preferably: the time is 75 minutes), merge extractive liquid, decompression and solvent recovery, to without alcohol taste, filter and collect filtrate;
(4) after Radix Cynanchi Atrati, the Rhizoma Anemarrhenae, pseudobulbus Calanthes fimbriatae, Lignum et Radix Naucleae and Poria being cleaned remove impurity, be placed in marmite, add boiled crude drug quality 5-7 water doubly (preferred: the water adding boiled crude drug quality 6 times) to decoct, big fire is heated to boiling, turns little fire and decocts 30-46 minute (preferably: little fire decocts 34-42 minute; Be more preferably: little fire decocts 38 minutes), filter and collect filtrate;
(5) Mannosum Kaki and step (1) (2) made crude drug are pulverized, mix homogeneously with step (3) (4) gained filtrate, obtain decoction.
4. the preparation method of chronic pharyngitis lung moistening detumescence preparation decoction as claimed in claim 3, is characterized in that, the amount that step (3) adds 80% ethanol is that the 3-6 of crude drug quality is doubly (preferred: the amount adding 80% ethanol is 4-5 times of crude drug quality; Be more preferably: the amount adding 80% ethanol is 4.5 times of crude drug quality).
5. the chronic pharyngitis lung moistening detumescence preparation as described in as arbitrary in claim 1-2, it is characterized in that, be made into pharmaceutically acceptable powder, its preparation method is:
(1) extracting honeysuckle, Herba Menthae, Folium Mori, Folium Violae Acuminatae and tilia amurensis removing impurity, add water clean, chopping is placed in container, adds Mel and wine is mixed thoroughly, and slow fire heats, constantly stir-fry to micro-Jiao, take out, dry in the air cool;
(2) get Resina Populi Diversifoliae to clean, be placed in frying pan, the micro-stir-fry of little fire, to smoldering, is taken out and is put into rice vinegar dipping 4-8 minute (preferred: to flood 6 minutes), repeat twice, take out, dry;
(3) Herba Bulbophylli Odoratissim, Herba Oxalidis Corniculatae, Herba galinsogae parviflorae and Herba Wedeliae Prostratae are picked up clean impurity, are cut into thread, add 80% alcohol reflux three times of crude drug quality 4.5 times, each extraction time be 60-90 minute (preferred: the time is 70-80 minute; Be more preferably: the time is 75 minutes), merge extractive liquid, decompression and solvent recovery, to without alcohol taste, filter and collect filtrate;
(4) after Radix Cynanchi Atrati, the Rhizoma Anemarrhenae, pseudobulbus Calanthes fimbriatae, Lignum et Radix Naucleae and Poria being cleaned remove impurity, be placed in marmite, add boiled crude drug quality 5-7 water doubly (preferred: the water adding boiled crude drug quality 6 times) to decoct, big fire is heated to boiling, turns little fire and decocts 30-46 minute (preferably: little fire decocts 34-42 minute; Be more preferably: little fire decocts 38 minutes), filter and collect filtrate;
(5) blend step (3) (4) gained filtrate, pulverizes and sieves with step (1) (2) gained crude drug after spraying dry, obtains powder together with Mannosum Kaki.
6. the preparation method of chronic pharyngitis lung moistening detumescence preparation powder as claimed in claim 5, it is characterized in that, it is (preferred: to pulverize 120-160 mesh sieve that step (5) pulverized 100-180 mesh sieve; Be more preferably: pulverized 140 mesh sieves).
7. the chronic pharyngitis lung moistening detumescence preparation as described in as arbitrary in claim 1-2, it is characterized in that, be made into pharmaceutically acceptable granule, its preparation method is:
(1) extracting honeysuckle, Herba Menthae, Folium Mori, Folium Violae Acuminatae and tilia amurensis removing impurity, add water clean, chopping is placed in container, adds Mel and wine is mixed thoroughly, and slow fire heats, constantly stir-fry to micro-Jiao, take out, dry in the air cool;
(2) get Resina Populi Diversifoliae to clean, be placed in frying pan, the micro-stir-fry of little fire, to smoldering, is taken out and is put into rice vinegar dipping 4-8 minute (preferred: to flood 6 minutes), repeat twice, take out, dry;
(3) Herba Bulbophylli Odoratissim, Herba Oxalidis Corniculatae, Herba galinsogae parviflorae and Herba Wedeliae Prostratae are picked up clean impurity, are cut into thread, add 80% alcohol reflux three times of crude drug quality 4.5 times, each extraction time be 60-90 minute (preferred: the time is 70-80 minute; Be more preferably: the time is 75 minutes), merge extractive liquid, decompression and solvent recovery, to without alcohol taste, filter and collect filtrate;
(4) after Radix Cynanchi Atrati, the Rhizoma Anemarrhenae, pseudobulbus Calanthes fimbriatae, Lignum et Radix Naucleae and Poria being cleaned remove impurity, be placed in marmite, add boiled crude drug quality 5-7 water doubly (preferred: the water adding boiled crude drug quality 6 times) to decoct, big fire is heated to boiling, turns little fire and decocts 30-46 minute (preferably: little fire decocts 34-42 minute; Be more preferably: little fire decocts 38 minutes), filter and collect filtrate;
(5) blend step (3) (4) gained filtrate, is evaporated to thick paste, is pulverized by Mannosum Kaki, be added in thick paste, dry, pulverize, granulate, pack and obtain granule together with step (1) (2) made crude drug.
8. the preparation method of chronic pharyngitis lung moistening detumescence preparation granules as claimed in claim 7 agent, is characterized in that, step (5) baking temperature is 60-80 DEG C (preferred: baking temperature is 70 DEG C).
9. the chronic pharyngitis lung moistening detumescence preparation as described in as arbitrary in claim 1-2, it is characterized in that, be made into pharmaceutically acceptable unguentum, its preparation method is:
(1) extracting honeysuckle, Herba Menthae, Folium Mori, Folium Violae Acuminatae and tilia amurensis removing impurity, add water clean, chopping is placed in container, adds Mel and wine is mixed thoroughly, and slow fire heats, constantly stir-fry to micro-Jiao, take out, dry in the air cool;
(2) get Resina Populi Diversifoliae to clean, be placed in frying pan, the micro-stir-fry of little fire, to smoldering, is taken out and is put into rice vinegar dipping 4-8 minute (preferred: to flood 6 minutes), repeat twice, take out, dry;
(3) Herba Bulbophylli Odoratissim, Herba Oxalidis Corniculatae, Herba galinsogae parviflorae and Herba Wedeliae Prostratae are picked up clean impurity, are cut into thread, add 80% alcohol reflux three times of crude drug quality 4.5 times, each extraction time be 60-90 minute (preferred: the time is 70-80 minute; Be more preferably: the time is 75 minutes), merge extractive liquid, decompression and solvent recovery, to without alcohol taste, filter and collect filtrate;
(4) after Radix Cynanchi Atrati, the Rhizoma Anemarrhenae, pseudobulbus Calanthes fimbriatae, Lignum et Radix Naucleae and Poria being cleaned remove impurity, be placed in marmite, add boiled crude drug quality 5-7 water doubly (preferred: the water adding boiled crude drug quality 6 times) and decoct, big fire is heated to boiling, turn little fire to decoct, filter and collect filtrate;
(5) blend step (3) (4) gained filtrate, is evaporated to thick paste, Mannosum Kaki was pulverized 120 mesh sieves together with step (1) (2) made crude drug, is added in thick paste, stirs, obtain unguentum.
10. the preparation method of chronic pharyngitis lung moistening detumescence preparation unguentum as claimed in claim 9, it is characterized in that, it is (preferred: little fire decocts 28-32 minute that step (4) turns little fire decoction 24-36 minute; Be more preferably: little fire decocts 30 minutes).
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| CN101558877A (en) * | 2009-02-23 | 2009-10-21 | 铜陵凯润牡丹生物医药科技有限公司 | Peony leaf-containing tea bag capable of clearing heat, reducing pathogenic fire, resisting bacteria and diminishing inflammation and preparation method thereof |
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| CN101558877A (en) * | 2009-02-23 | 2009-10-21 | 铜陵凯润牡丹生物医药科技有限公司 | Peony leaf-containing tea bag capable of clearing heat, reducing pathogenic fire, resisting bacteria and diminishing inflammation and preparation method thereof |
| TWI379688B (en) * | 2009-10-05 | 2012-12-21 | Univ China Medical | Anoectochilus spp. polysaccharide extracts and pharmaceutical compositions for stimulating growth of advantageous bacteria, stimulating release of granulocyte colony-stimulating factor, modulating t helper cell type i, and/or modulating t helper cell typ |
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