CN104721795A - Oral medicine for treating pertussis and preparation method thereof - Google Patents

Abstract

The invention relates to an oral medicine for treating pertussis and a preparation method thereof. The oral medicine comprises the following components in parts by mass: 1-3 parts of perillaseed, 1-3 parts of semen raphani, 1-3 parts of semen lepidii, 1-3 parts of pericarpium papaveris, 1-3 parts of apricot kernel, 1-3 parts of prepared pinellia tuber, 1-3 parts of radix stemonae root, 1-3 parts of poria cocos, 1-3 parts of adenophora tetraphylla, 1-3 parts of Zhejiang fritillary, 1-3 parts of pericarpium citri reticulatae, 1-3 parts of ginger, and 1-3 parts of red dates. The preparation method of the oral medicine comprises the following steps of: selecting high-quality, clean and first-grade perillaseed, semen raphani, semen lepidii, pericarpium papaveris, apricot kernel, prepared pinellia tuber, radix stemonae root, poria cocos, adenophora tetraphylla, Zhejiang fritillary, pericarpium citri reticulatae, ginger and red dates according to the parts by mass, and respectively removing impurities and dust, for use; and putting all the medicines in a cloth bag to tie, immersing in cold boiled water for about half an hour, then, putting the immersed medicines and clarified solution for immersing the medicines into an earthen pot together, injecting cold boiled water till the cold boiled water is 30 mm higher than the medicines, decocting for 30 min for the first time, filtering to obtain medicinal solution, injecting slight warm boiled water again to decoct for 25 min for the second time, mixing medicinal solution obtained by the two steps, and concentrating into 720 ml of 50% traditional Chinese medicine solution.

Description

One treats pertussal endo-medicine and preparation method thereof

Technical field

The present invention relates to field of Chinese herbal medicine technology, be specifically related to one and treat pertussal endo-medicine, particularly for the field of the endo-medicine and preparation method thereof of pertussis patient.

Background technology

Pertussis is commonly called as pertussis, cough with sound like cormorant cry, and neonate and infant patient easily suffocate threat to life.It is characterized by paroxysmal spasmodic cough, cough end is with special air-breathing roar, and the course of disease is longer, can reach even about 3 months several weeks, therefore have the title of pertussis.Children baby easily have when suffering from primary disease suffocate, the complication such as pneumonia, encephalopathy, case fatality rate is high.Young baby and Adult Onset have and increase trend in recent years, and in death, 40% is the infant within 5 months.Apply antibiotic therapy early, general prognosis bona.These sick various places all over the world, generally in distributing shape, can happening and prevelence in mechanism of child collective.The whole year all can fall ill, and be many with winter-spring season, can be extended down to the end of spring and the beginning of summer, even peak is in 6,7,8 three month.Patient and Asympto matic carrier are the sources of infection, be all infectious, pass through droplet transmission from incubation period by the 6th week.Crowd is to the general susceptible of this disease, and the case of about 2/3 is less than 7 years old children's, especially many with less than 5 years old person.The specific antibody obtained from parent because of infant is few, susceptible the most.Generally after being ill can lasting immunity.

So, just how finding one can effectively treat pertussal endo-medicine, is our current problem in urgent need to solve.

Summary of the invention

The object of this invention is to provide one and treat pertussal endo-medicine and preparation method thereof, to solve pertussis patient restorative problem early.This medicine is that have compatibility science, primary and secondary is orderly, and the efficacy of a drug is powerful, and hit pathogenesis, has fully demonstrated the Therapeutic Principle of alleviating distention in middle-JIAO dispersing lung-QI and dissipating phlegm with common Chinese herbal medicine for raw material.

For reaching the object of foregoing invention, the technical solution adopted in the present invention is: provide one to treat pertussal endo-medicine and preparation method thereof, it is characterized in that, each component of described medicine and mass parts thereof are than as follows:

Fructus Perillae 1-3 part;

Semen Raphani 1-3 part;

Semen Lepidii (Semen Descurainiae) 1-3 part;

Pericarpium Papaveris 1-3 part;

Semen Armeniacae Amarum 1-3 part;

Rhizoma Pinelliae Preparata 1-3 part;

Radix Stemonae 1-3 part;

Poria 1-3 part;

Radix Adenophorae 1-3 part;

Bulbus Fritillariae Thunbergii 1-3 part;

Pericarpium Citri Reticulatae 1-3 part;

Rhizoma Zingiberis Recens 1-3 part;

Fructus Jujubae 1-3 part.

According to the pertussal endo-medicine for the treatment of provided by the present invention, it is characterized in that, each component of described medicine and mass parts thereof are than as follows:

Fructus Perillae 1 part;

Semen Raphani 1 part;

Semen Lepidii (Semen Descurainiae) 1 part;

Pericarpium Papaveris 1 part;

1 part, Semen Armeniacae Amarum;

Rhizoma Pinelliae Preparata 1 part;

Radix Stemonae 1 part;

1 part, Poria;

Radix Adenophorae 1 part;

Bulbus Fritillariae Thunbergii 1 part;

Pericarpium Citri Reticulatae 1 part;

1 part, Rhizoma Zingiberis Recens;

Fructus Jujubae 1 part.

One treats pertussal endo-medicine and preparation method thereof, it is characterized in that, described method comprises the steps:

A, the one-level Fructus Perillae 1 part selecting high-quality clean, Semen Raphani 1 part, Semen Lepidii (Semen Descurainiae) 1 part, Pericarpium Papaveris 1 part, 1 part, Semen Armeniacae Amarum, Rhizoma Pinelliae Preparata 1 part, Radix Stemonae 1 part, 1 part, Poria, Radix Adenophorae 1 part, Bulbus Fritillariae Thunbergii 1 part, Pericarpium Citri Reticulatae 1 part, 1 part, Rhizoma Zingiberis Recens, Fructus Jujubae 1 part, for subsequent use after picking decontamination and dust respectively;

In B, all medicines loading cloth bag after tying, soak half an hour in cold boiled water about, with osmotic drug degree of being organized as, and then the clear liquor of soaked medicine and soak medicine is put into marmite in the lump, inject the cold boiled water of medicine 30mm, carry out first time decoction 30 minutes, after leaching medicinal liquid, re-inject tepor boiled water and carry out second time decoction 25 minutes, twice mixing is condensed into the herb liquid 720 milliliters of 50%.

One treats pertussal endo-medicine and preparation method thereof, it is characterized in that, described instructions of taking is: divided by the herb liquid prepared and take for two days, the morning, noon and afternoon service once, dosage 120 milliliters/time.Ante cibum decoction being taken warmly, 2-5 agent of taking medicine, all except and heal.

Medicine provided by the present invention is oral traditional Chinese medicine composition, and it for raw material, gives full play to effect of each component with common Chinese herbal medicine:

Fructus Perillae, nature and flavor: pungent, warm, have sending down the abnormal ascending QI expectorant, relieving asthma, effect of intestine moistening, are used for the treatment of expectorant and stop up QI rising in reverse order, cough and asthma, dryness of the intestine constipation;

Semen Raphani, nature and flavor: pungent, sweet, flat, have effect of the de-swelling that helps digestion, lowering the adverse-rising QI to resolve phlegm, be used for the treatment of retention of food and drink, abdominal distention, constipation, stagnant dysentery, expectorant stops up and breath with cough;

Semen Lepidii (Semen Descurainiae), nature and flavor: property Great Cold, acrid in the mouth, hardship, have effect of eliminating pathogen from the lung for relieving asthma, line water detumescence, be used for the treatment of sputum stop up lung, dyspnea and cough with excessive sputum, fullness and distention in the chest and hypochondrium, must not put down sleeping, ascites pleural fluid swollen, dysuria;

Pericarpium Papaveris, nature and flavor: sour, puckery, flat, poisonous, have astringe the lung, astringing intestine to stop diarrhea, pain relieving effect, be used for the treatment of chronic cough, chronic diarrhea, proctoptosis, epigastric pain;

Semen Armeniacae Amarum, nature and flavor: bitter in the mouth, slightly warm in nature, have effect of sending down the abnormal ascending QI relieving cough and asthma, loosening bowel to relieve constipation, are used for the treatment of that cough and asthma, fullness in the chest abundant expectoration, blood deficiency Tianjin are withered, dryness of the intestine constipation;

Rhizoma Pinelliae Preparata, nature and flavor: pungent, warm, poisonous, have effect of drying dampness to eliminate phlegm, stopping nausea and vomiting by lowering the adverse flow of QI, dissolving lump and resolving mass, are used for the treatment of cough due to damp-phlegm, dizziness due to wind-phlegm, syncope due to accumulation of phlegm headache, vomit regurgitation, breast gastral cavity painful abdominal mass is vexed, globus hystericus, gall subcutaneous nodule, swollen ulcer drug;

Radix Stemonae, nature and flavor: sweet, bitter, tepor, have effect of nourishing the lung to arrest cough, parasite killing delousing, be used for the treatment of that new chronic cough is coughed, pulmonary tuberculosis, pertussis, enterobiasis, body louse, tinea scabies;

Poria, nature and flavor: sweet in the mouth, light, property are put down, and have effect of promoting diuresis to eliminate damp pathogen, invigorating the spleen and regulating the stomach, mind tranquilizing and the heart calming, are used for the treatment of edema, have loose bowels in oliguria, phlegm retention vertigo and palpitation, insufficiency of the spleen lack of appetite, loose stool, peaceful uneasy, the palpitation with fear insomnia of the heart;

Radix Adenophorae, nature and flavor: sweet, be slightly cold, have nourishing YIN and clearing away lung-heat, reduce phlegm, effect of QI invigorating, are used for the treatment of that lung-heat type cough, deficiency of YIN chronic cough, dry cough expectorant are glutinous, deficiency of both vital energy and Yin, restlessness and fever with thirst;

Bulbus Fritillariae Thunbergii, nature and flavor: bitter in the mouth, cold in nature, have effect of removing heat-phlegm, sending down the abnormal ascending QI cough-relieving, mass dissipating and swelling eliminating, are used for the treatment of the disease such as wind heat or phlegm-heat cough, lung abscess vomiting pus, scrofula goiter, sore and toxic;

Pericarpium Citri Reticulatae, nature and flavor: acrid in the mouth, hardship, warm in nature, there is regulating the flow of Qi and the middle Jiao, drying dampness to eliminate phlegm, effect of diuretic relieving constipation, is used for the treatment of incoordination between the spleen and stomach, abdominal distention, anorexia, vomiting hiccup, accumulation of phlegm-damp in the lung, cough with copious phlegm, chest and diaphragm full vexed, the vertigo, edema, dysuria, constipation, acute mastitis scabies, middle fish Eriocheir sinensis poison, alcoholism etc.;

Rhizoma Zingiberis Recens, nature and flavor: tepor, pungent, have effect of the cold expelling that induces sweat, warming middle-JIAO to arrest vomiting, preventing phlegm from forming and stopping coughing, are used for the treatment of anemofrigid cold, gastrofrigid vomiting, cold-phlegm cough;

Fructus Jujubae, nature and flavor: sweet in the mouth, warm in nature, have effect of invigorating the spleen and replenishing QI, spleen reinforcing stomach function regulating, nourishing blood to tranquillize the mind, the mitigation property of medicine, are used for the treatment of insufficiency of stomach lack of appetite, the weak loose stool of spleen, qi-blood-body fluid deficiency, disharmony of nutrient QI with defensive QI, severe palpitation.

When taking, divided by the herb liquid prepared and take for two days, the morning, noon and afternoon service once, dosage 120 milliliters/time.Ante cibum decoction being taken warmly, 2-5 agent of taking medicine, all except and heal.This medicine is that have compatibility science, primary and secondary is orderly, and the efficacy of a drug is powerful, and hit pathogenesis, has fully demonstrated the Therapeutic Principle of alleviating distention in middle-JIAO dispersing lung-QI and dissipating phlegm with common Chinese herbal medicine for raw material.

Detailed description of the invention

Below embodiments of the present invention are described in detail

Pertussis is commonly called as pertussis, cough with sound like cormorant cry, and neonate and infant patient easily suffocate threat to life.It is characterized by paroxysmal spasmodic cough, cough end is with special air-breathing roar, and the course of disease is longer, can reach even about 3 months several weeks, therefore have the title of pertussis.Children baby easily have when suffering from primary disease suffocate, the complication such as pneumonia, encephalopathy, case fatality rate is high.Young baby and Adult Onset have and increase trend in recent years, and in death, 40% is the infant within 5 months.Apply antibiotic therapy early, general prognosis bona.These sick various places all over the world, generally in distributing shape, can happening and prevelence in mechanism of child collective.The whole year all can fall ill, and be many with winter-spring season, can be extended down to the end of spring and the beginning of summer, even peak is in 6,7,8 three month.Patient and Asympto matic carrier are the sources of infection, be all infectious, pass through droplet transmission from incubation period by the 6th week.Crowd is to the general susceptible of this disease, and the case of about 2/3 is less than 7 years old children's, especially many with less than 5 years old person.The specific antibody obtained from parent because of infant is few, susceptible the most.Generally after being ill can lasting immunity.

The present invention is exactly a kind of Chinese herbal medicine formula proposed for above-mentioned pertussal treatment, adopts herb liquid prepared by this formula, good drug efficacy, instant effect, has no side effect, effectively can treat pertussis.Below specific embodiment provided by the present invention is described in detail.

Embodiment 1:

The one-level Fructus Perillae 10 grams selecting high-quality clean, Semen Raphani 10 grams, Semen Lepidii (Semen Descurainiae) 3 grams, Pericarpium Papaveris 10 grams, 10 grams, Semen Armeniacae Amarum, Rhizoma Pinelliae Preparata 5 grams, Radix Stemonae 10 grams, 10 grams, Poria, Radix Adenophorae 10 grams, Bulbus Fritillariae Thunbergii 10 grams, Pericarpium Citri Reticulatae 5 grams, 3 grams, Rhizoma Zingiberis Recens, Fructus Jujubae 5 pieces, for subsequent use after picking decontamination and dust respectively; In all medicine loading cloth bags after tying, soak half an hour in cold boiled water about, with osmotic drug degree of being organized as, and then the clear liquor of soaked medicine and soak medicine is put into marmite in the lump, inject the cold boiled water of medicine 30mm, carry out first time decoction 30 minutes, after leaching medicinal liquid, re-inject tepor boiled water and carry out second time decoction 25 minutes, twice mixing is condensed into the herb liquid 720 milliliters of 50%.When taking, divided by the herb liquid prepared and take for two days, the morning, noon and afternoon service once, dosage 120 milliliters/time.Ante cibum decoction being taken warmly, 2-5 agent of taking medicine, all except and heal.

Embodiment 2:

The one-level Fructus Perillae 12 grams selecting high-quality clean, Semen Raphani 12 grams, Semen Lepidii (Semen Descurainiae) 4 grams, Pericarpium Papaveris 12 grams, 12 grams, Semen Armeniacae Amarum, Rhizoma Pinelliae Preparata 8 grams, Radix Stemonae 12 grams, 12 grams, Poria, Radix Adenophorae 12 grams, Bulbus Fritillariae Thunbergii 12 grams, Pericarpium Citri Reticulatae 6 grams, 3.5 grams, Rhizoma Zingiberis Recens, Fructus Jujubae 6 pieces, for subsequent use after picking decontamination and dust respectively; In all medicine loading cloth bags after tying, soak half an hour in cold boiled water about, with osmotic drug degree of being organized as, and then the clear liquor of soaked medicine and soak medicine is put into marmite in the lump, inject the cold boiled water of medicine 30mm, carry out first time decoction 30 minutes, after leaching medicinal liquid, re-inject tepor boiled water and carry out second time decoction 25 minutes, twice mixing is condensed into the herb liquid 720 milliliters of 50%.When taking, divided by the herb liquid prepared and take for two days, the morning, noon and afternoon service once, dosage 120 milliliters/time.Ante cibum decoction being taken warmly, 2-3 agent of taking medicine, all except and heal.

Embodiment 3:

The one-level Fructus Perillae 10 grams selecting high-quality clean, Semen Raphani 10 grams, Semen Lepidii (Semen Descurainiae) 3 grams, Pericarpium Papaveris 10 grams, 10 grams, Semen Armeniacae Amarum, Rhizoma Pinelliae Preparata 5 grams, Radix Stemonae 10 grams, 10 grams, Poria, Radix Adenophorae 10 grams, Bulbus Fritillariae Thunbergii 10 grams, Pericarpium Citri Reticulatae 5 grams, 3 grams, Rhizoma Zingiberis Recens, Fructus Jujubae 5 pieces, for subsequent use after picking decontamination and dust respectively; In all medicine loading cloth bags after tying, soak half an hour in cold boiled water about, with osmotic drug degree of being organized as, and then the clear liquor of soaked medicine and soak medicine is put into marmite in the lump, inject the cold boiled water of medicine 30mm, carry out first time decoction 30 minutes, after leaching medicinal liquid, re-inject tepor boiled water and carry out second time decoction 25 minutes, twice mixing is condensed into the herb liquid 720 milliliters of 50%.When taking, divided by the herb liquid prepared and take for two days, the morning, noon and afternoon service once, dosage 120 milliliters/time.Ante cibum decoction being taken warmly, 2-4 agent of taking medicine, all except and heal.

The present invention is through the treatment to nearly one hundred routine patient, and therapeutic effect is remarkable, has no side effect, and part allusion quotation shape case is as follows.

1, patient: leaf XX, man, 5 years old half, address: Chengdu, Sichuan Province

Illness symptom: pertussis a few days, spirit, appetite are general, and without fever with aversion to cold, premorbid is without other obvious clinical manifestation.Paroxysmal is choked and is coughed, tachypnea, and expectorant is white thick slightly yellow, and with wheezing sound between coughing, two conjunctive bulbis are congested, cough and very vomit gastric food and sputum.On inspection, be diagnosed as " pertussis ".

Treatment: throw top control it, every day potion, clothes top 2 doses after check, symptom disappears substantially, takes medicine again 1 dose, all except and heal.Follow up a case by regular visits to 3 year, have no recurrence.

2, patient: clock XX, man, 5 years old, address: Wu Hou district, Chengdu, Sichuan Province

Illness symptom: go to a doctor on April 10th, 1998.Its female Dai Shu: the nearly first quarter moon of infant pertussis, spirit, appetite are general, without fever with aversion to cold.Paroxysmal is choked and is coughed, tachypnea, and expectorant is white thick slightly yellow, and with wheezing sound between coughing, two conjunctive bulbis are congested, cough and very vomit gastric food and sputum.Be diagnosed as on inspection: pertussis.

Treatment: throw top control it, every day potion, clothes top 2 doses after check, transference cure, advises it to consolidate again and takes medicine 1 dose.Follow up a case by regular visits to 4 years, have no recurrence.

3, patient: Xiao XX, female, 4 years old half, address: Sichuan Province Peng Zhouxian

Illness symptom: gone to a doctor on July 10th, 2000.More than pertussis January, spirit, food of receiving are general, and without fever with aversion to cold, premorbid is without other obvious clinical manifestation.Paroxysmal is choked and is coughed, tachypnea, and expectorant is white thick slightly yellow, and with wheezing sound between coughing, two conjunctive bulbis are congested, cough and very vomit gastric food and sputum.Be diagnosed as pertussis.

Treat: throw top and control it, every day, potion, checked after 3 doses above clothes, and all diseases are all removed and heal, and advise it to consolidate again and take medicine 1 dose.Follow up a case by regular visits to after 8 year, have no recurrence.

Claims (3)

1. treat a pertussal endo-medicine, it is characterized in that, each component of described medicine and mass parts thereof are than as follows:

Fructus Perillae 1-3 part;

Semen Raphani 1-3 part;

Semen Lepidii (Semen Descurainiae) 1-3 part;

Pericarpium Papaveris 1-3 part;

Semen Armeniacae Amarum 1-3 part;

Rhizoma Pinelliae Preparata 1-3 part;

Radix Stemonae 1-3 part;

Poria 1-3 part;

Radix Adenophorae 1-3 part;

Bulbus Fritillariae Thunbergii 1-3 part;

Pericarpium Citri Reticulatae 1-3 part;

Rhizoma Zingiberis Recens 1-3 part;

Fructus Jujubae 1-3 part.

2. the pertussal endo-medicine for the treatment of according to claim 1, is characterized in that, each component of described medicine and mass parts thereof are than as follows:

Fructus Perillae 1 part;

Semen Raphani 1 part;

Semen Lepidii (Semen Descurainiae) 1 part;

Pericarpium Papaveris 1 part;

1 part, Semen Armeniacae Amarum;

Rhizoma Pinelliae Preparata 1 part;

Radix Stemonae 1 part;

1 part, Poria;

Radix Adenophorae 1 part;

Bulbus Fritillariae Thunbergii 1 part;

Pericarpium Citri Reticulatae 1 part;

1 part, Rhizoma Zingiberis Recens;

Fructus Jujubae 1 part.

3. pertussal endo-medicine for the treatment of described in a claim 1 or 2 and preparation method thereof, is characterized in that, described method comprises the steps:

A, according to mass parts than selecting the clean one-level Fructus Perillae of high-quality, Semen Raphani, Semen Lepidii (Semen Descurainiae), Pericarpium Papaveris, Semen Armeniacae Amarum, Rhizoma Pinelliae Preparata, Radix Stemonae, Poria, Radix Adenophorae, Bulbus Fritillariae Thunbergii, Pericarpium Citri Reticulatae, Rhizoma Zingiberis Recens and Fructus Jujubae, for subsequent use after picking decontamination and dust respectively;

In B, all medicines loading cloth bag after tying, soak half an hour in cold boiled water about, with osmotic drug degree of being organized as, and then the clear liquor of soaked medicine and soak medicine is put into marmite in the lump, inject the cold boiled water of medicine 30mm, carry out first time decoction 30 minutes, after leaching medicinal liquid, re-inject tepor boiled water and carry out second time decoction 25 minutes, twice mixing is condensed into the herb liquid 720 milliliters of 50%.