CN104707011B - Treat herbal mixture and the application of Sjogren syndrome - Google Patents
Treat herbal mixture and the application of Sjogren syndrome Download PDFInfo
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Abstract
The invention discloses a kind of Chinese medicine for treating Sjogren syndrome and its application, Chinese medicine includes gypsum, rhizoma anemarrhenae, reed root, selfheal, mulberry leaf, chrysanthemum, radix astragali, Radix Glehniae, ophiopogon, the dried rhizome of rehmannia, pueraria lobata, the root of bidentate achyranthes by weight, the Chinese medicine of the treatment Sjogren syndrome of the present invention, has the function of clearing stomach purging the liver of pathogenic fire, removes and hot deposit Tianjin.Present invention treatment Sjogren syndrome has unique advantage, it can obviously improve Sjogren syndrome dry, xerophthalmia shape, improve disorderly immune function, its curative effect is better than the therapeutic effect of immunodepressant, and induce the side effect such as liver and kidney dysfunction and bone marrow suppression without immunodepressant, for the effective pure Chinese medicinal preparation of clinical safety, and available for the medicament for preparing treatment Sjogren syndrome.
Description
Technical field
The present invention relates to a kind of herbal mixture for being used to treat rheumatoid disease, and in particular to treats the Chinese medicine of Sjogren syndrome
Composition.
Background technology
Sjogren syndrome is that a reason is unknown, autoimmunity disease characterized by exocrine gland height lymphocytic infiltration
Disease.It is clinical using mouth, xerophthalmia scheorma mainly to show to invade lachrymal gland, based on salivary gland, can also be with symptom outside body of gland, such as joint
The symptoms such as inflammation, myalgia, fash, rampant carious tooth.The disease is 0.3%~0.7% in the illness rate of population of China, its incidence exists
The 2nd is occupied in rheumatism immunological disease.But there is no specific medicament currently on the market, mostly using symptomatic treatment or using immunosupress
Agent, but since uncertain therapeutic efficacy is fixed or the reasons such as toxic side effect is big, cause the phenomenon of Sjogren syndrome " pasting medical help ".Therefore, seek
The method of safe and effective improvement Sjogren syndrome is looked for just to be expected by clinician.
According to the sings and symptoms of Sjogren syndrome, the category such as traditional Chinese medical science ownership " dry numbness ", dry dry, eye are xerotic masters
Clinical symptoms are wanted, scorching to suffer from, stomach energy is contained partially, and stomach and intestine Tianjin wound, body fluid deficiency holds then mouth parched and tongue scorched, deep red tongue, no saliva without more than.Liver
Have one's ideas straightened out in mesh, tears being related to the liver, liver heat is followed through upper note in mesh system, then eye do, eye itch puckery pain, be too deep for tears, the fear of shy light is bright, mesh is red
It is red etc., therefore syndrome of liver-stomach heat is the crucial interpretation of the cause, onset and process of an illness for causing body fluid to lose, clearing stomach purging the liver of pathogenic fire is the main therapy of Sjogren syndrome.Do at the same time
Dry syndrome is apt to occur in 40 years old later women, and climacteric is that scorching easy injury-gas consumption, can above burn an important factor for inducing this disease
Hinder lung Tianjin, lower the moon that can consume liver kidney, causes the interpretation of the cause, onset and process of an illness of deficiency of both qi and yin, therefore removes that heat deposits Tianjin, supplementing qi and nourishing yin is Sjogren syndrome
Basic therapy.Traditional Chinese medical herbal treatment Sjogren syndrome it is with the obvious advantage, most Patients with Sjogren Syndrome are treated through simple Chinese medicine,
Mouthful xerophthalmia shape, a visceral injury can be obviously improved, and curative effect can be better than western medicine treatment effect, hence it is evident that improve the life matter of patient
Amount.
In the prior art, Chinese patent database discloses the herbal mixture of several treatment Sjogren syndromes (such as
CN101804174B, CN102813832B, CN102526596A, CN102772671A, CN103055034A etc.), above-mentioned patent
Disclosed medicine is using supplementing qi and nourishing yin as the main principles of formulating prescriptions, even if taking into account, taste is scorching, its effect is little；And currently on the market
Also without the Chinese patent drug for intervening Sjogren syndrome.
Therefore, it is necessary to a kind of present invention to be directed to the deficiencies in the prior art and defect, there is provided it is comprehensive that one kind treats drying
The herbal mixture of simulator sickness, make it have remove heat deposit based on Tianjin, assistant with the effect of supplementing qi and nourishing yin, to treat both principal and secondary aspect of disease, safely and effectively
Pure Chinese medicinal preparation.
The content of the invention
In view of this, it is an object of the invention to provide a kind of herbal mixture of Sjogren syndrome, by improving exocrine gland work(
Can, there is clearing stomach purging the liver of pathogenic fire, removes heat and deposits Tianjin, is safely and effectively pure Chinese medicinal preparation, has no toxic side effect.
The Chinese medicine of the treatment Sjogren syndrome of the present invention, the Chinese medicine material include following components by weight：
10-30 parts of gypsum, 5-15 parts of rhizoma anemarrhenae, 10-30 parts of reed root, 5-15 parts of selfheal, 5-15 parts of mulberry leaf, chrysanthemum 5-15
Part, 30-60 parts of radix astragali, 10-30 parts of Radix Glehniae, ophiopogon 5-15 part, 5-15 parts of the dried rhizome of rehmannia, 5-30 parts of pueraria lobata, 5-15 parts of the root of bidentate achyranthes；
Further, the Chinese medicine material includes following components by weight：
10-25 parts of gypsum, 5-12 parts of rhizoma anemarrhenae, 10-26 parts of reed root, 5-12 parts of selfheal, 5-12 parts of mulberry leaf, chrysanthemum 5-12
Part, 30-55 parts of radix astragali, 10-25 parts of Radix Glehniae, ophiopogon 5-12 part, 5-12 parts of the dried rhizome of rehmannia, 5-26 parts of pueraria lobata, 5-12 parts of the root of bidentate achyranthes；
Further, the Chinese medicine material includes following components by weight：
15-25 parts of gypsum, 8-12 parts of rhizoma anemarrhenae, 15-26 parts of reed root, 8-12 parts of selfheal, 8-12 parts of mulberry leaf, chrysanthemum 8-12
Part, 40-55 parts of radix astragali, 15-25 parts of Radix Glehniae, ophiopogon 8-12 part, 8-12 parts of the dried rhizome of rehmannia, 10-26 parts of pueraria lobata, 8-12 parts of the root of bidentate achyranthes；
Further, the Chinese medicine material includes following components by weight：
18-25 parts of gypsum, 8-12 parts of rhizoma anemarrhenae, 18-26 parts of reed root, 8-12 parts of selfheal, 8-12 parts of mulberry leaf, chrysanthemum 8-12
Part, 45-50 parts of radix astragali, 18-22 parts of Radix Glehniae, ophiopogon 8-12 part, 8-12 parts of the dried rhizome of rehmannia, 15-22 parts of pueraria lobata, 8-12 parts of the root of bidentate achyranthes；
Further, the Chinese medicine material includes following components by weight：
22 parts of gypsum, 10 parts of rhizoma anemarrhenae, 22 parts of reed root, 10 parts of selfheal, 10 parts of mulberry leaf, 10 parts of chrysanthemum, 48 parts of radix astragali, north
20 parts of the root of straight ladybell, 10 parts of ophiopogon, 10 parts of the dried rhizome of rehmannia, 18 parts of pueraria lobata, 10 parts of the root of bidentate achyranthes；
Further, one or more Chinese medicines for being used to improving or treating accompanying symptoms can be added during the Chinese medicine use.
Further, which can add preparation made of the acceptable pharmaceutical carrier of medicine.
Invention additionally discloses a kind of Chinese medicine for treating Sjogren syndrome to prepare the application in treating Sjogren syndrome medicine.
Beneficial effects of the present invention：The present invention treatment Sjogren syndrome Chinese medicine, have clearing stomach purging the liver of pathogenic fire, remove heat deposit Tianjin
Effect, for safely and effectively pure Chinese medicinal preparation.
The present invention is directed to the basic pathogenesis of Sjogren syndrome, takes into full account drug matching principle, gypsum, rhizoma anemarrhenae, reed in side
Root clearing stomach expels the heat-evil to control dry as monarch drug in a prescription, and selfheal, mulberry leaf, chrysanthemum clear liver, soothing the liver purging intense heat is done as ministerial drug with controlling eye, and six medicines share
Chilly syndrome of liver-stomach heat is played altogether；To control weak body fluid deficiency, pueraria lobata dissipates spleen Sheng Jin, mulberry for radix astragali, Radix Glehniae, ophiopogon, dried rhizome of rehmannia supplementing qi and nourishing yin in side
Leaf facilitaing lung cloth Tianjin, two medicines promote the defeated cloth of body fluid, are altogether adjutant；Root of bidentate achyranthes filling liver kidney, draw behavior under heat and make medicine.All medicines share plays remove altogether
Heat deposits Tianjin, the work(of supplementing qi and nourishing yin, to dispel based on the loss of scorching reduction body fluid, while is made up with supplementing qi and nourishing yin supplemented by loss,
Improve eccrine function so as to reach.Our compatibility has following features, and 1. heat-clearing is combined with help, based on clear；②
Liver stomach is followed through treatment with controlling.3. rise spleen facilitaing lung, transporation of body fluid.Clinically the present invention can obviously improve a mouthful Dry eye, promote
Exocrine glandular function recovers.
Embodiment
The Chinese medicine of the treatment Sjogren syndrome of the present embodiment, the Chinese medicine material include following components by weight：
10-30 parts of gypsum, 5-15 parts of rhizoma anemarrhenae, 10-30 parts of reed root, 5-15 parts of selfheal, 5-15 parts of mulberry leaf, chrysanthemum 5-15
Part, 30-60 parts of radix astragali, 10-30 parts of Radix Glehniae, ophiopogon 5-15 part, 5-15 parts of the dried rhizome of rehmannia, 5-30 parts of pueraria lobata, 5-15 parts of the root of bidentate achyranthes；Fully
Consider drug matching principle, in side gypsum, rhizoma anemarrhenae, reed root clearing stomach expel the heat-evil to control dry as monarch drug in a prescription, selfheal, mulberry leaf, chrysanthemum are clear
Liver, soothing the liver purging intense heat are done as ministerial drug with controlling eye, and six medicines share and play Chilly syndrome of liver-stomach heat altogether；Radix astragali, Radix Glehniae, ophiopogon, dried rhizome of rehmannia benefit in side
Gas yin-nourishing is to control weak body fluid deficiency, and pueraria lobata dissipates spleen and rises Tianjin, mulberry leaf facilitaing lung cloth Tianjin, and two medicines promote the defeated cloth of body fluid, are altogether adjutant；The root of bidentate achyranthes is mended
Liver kidney, draw behavior under heat and make medicine.
Preferred embodiment is that the Chinese medicine material includes following components by weight：
10-25 parts of gypsum, 5-12 parts of rhizoma anemarrhenae, 10-26 parts of reed root, 5-12 parts of selfheal, 5-12 parts of mulberry leaf, chrysanthemum 5-12
Part, 30-55 parts of radix astragali, 10-25 parts of Radix Glehniae, ophiopogon 5-12 part, 5-12 parts of the dried rhizome of rehmannia, 5-26 parts of pueraria lobata, 5-12 parts of the root of bidentate achyranthes；
More preferred embodiment is that the Chinese medicine material includes following components by weight：
15-25 parts of gypsum, 8-12 parts of rhizoma anemarrhenae, 15-26 parts of reed root, 8-12 parts of selfheal, 8-12 parts of mulberry leaf, chrysanthemum 8-12
Part, 40-55 parts of radix astragali, 15-25 parts of Radix Glehniae, ophiopogon 8-12 part, 8-12 parts of the dried rhizome of rehmannia, 10-26 parts of pueraria lobata, 8-12 parts of the root of bidentate achyranthes；
More preferred embodiment is that the Chinese medicine material includes following components by weight：
18-25 parts of gypsum, 8-12 parts of rhizoma anemarrhenae, 18-26 parts of reed root, 8-12 parts of selfheal, 8-12 parts of mulberry leaf, chrysanthemum 8-12
Part, 45-50 parts of radix astragali, 18-22 parts of Radix Glehniae, ophiopogon 8-12 part, 8-12 parts of the dried rhizome of rehmannia, 15-22 parts of pueraria lobata, 8-12 parts of the root of bidentate achyranthes；
Most preferred embodiment is that the Chinese medicine material includes following components by weight：
22 parts of gypsum, 10 parts of rhizoma anemarrhenae, 22 parts of reed root, 10 parts of selfheal, 10 parts of mulberry leaf, 10 parts of chrysanthemum, 48 parts of radix astragali, north
20 parts of the root of straight ladybell, 10 parts of ophiopogon, 10 parts of the dried rhizome of rehmannia, 18 parts of pueraria lobata, 10 parts of the root of bidentate achyranthes；
In the present embodiment, when Chinese medicine use, can add one or more Chinese medicines for being used to improving or treating accompanying symptoms.
In the present embodiment, the Chinese medicine can add the acceptable pharmaceutical carrier of medicine made of preparation, can be made into pulvis, water
Agent or tablet.
Invention additionally discloses a kind of Chinese medicine for treating Sjogren syndrome to prepare the application in treating Sjogren syndrome medicine.
Below by specific embodiment, the present invention is further elaborated.
Embodiment one
The Chinese medicine of the present embodiment includes following component by weight：Gypsum 20, rhizoma anemarrhenae 5, reed root 20, selfheal 5, mulberry leaf
15th, chrysanthemum 15, radix astragali 45, Radix Glehniae 10, ophiopogon 10, the dried rhizome of rehmannia 5, pueraria lobata 30, the root of bidentate achyranthes 5.
Embodiment two
The Chinese medicine of the present embodiment includes following component by weight：Gypsum 30, rhizoma anemarrhenae 15, reed root 30, selfheal 15, mulberry leaf
10th, chrysanthemum 10, radix astragali 60, Radix Glehniae 30, ophiopogon 15, the dried rhizome of rehmannia 15, pueraria lobata 15, the root of bidentate achyranthes 15.
Embodiment three
The Chinese medicine of the present embodiment includes following component by weight：Gypsum 10, rhizoma anemarrhenae 10, reed root 10, selfheal 10, mulberry leaf
5th, chrysanthemum 5, radix astragali 30, Radix Glehniae 20, ophiopogon 5, the dried rhizome of rehmannia 10, pueraria lobata 10, the root of bidentate achyranthes 10.
Example IV
The Chinese medicine of the treatment Sjogren syndrome of the present embodiment, the Chinese medicine material include following components by weight：
10 parts of gypsum, 5 parts of rhizoma anemarrhenae, 10 parts of reed root, 5 parts of selfheal, 5 parts of mulberry leaf, 5 parts of chrysanthemum, 30 parts of radix astragali, Radix Glehniae 10
Part, 5 parts of ophiopogon, 5 parts of the dried rhizome of rehmannia, 5 parts of pueraria lobata, 5 parts of the root of bidentate achyranthes.
Embodiment five
The Chinese medicine of the treatment Sjogren syndrome of the present embodiment, the Chinese medicine material include following components by weight：
30 parts of gypsum, 15 parts of rhizoma anemarrhenae, 30 parts of reed root, 15 parts of selfheal, 15 parts of mulberry leaf, 15 parts of chrysanthemum, 60 parts of radix astragali, north
30 parts of the root of straight ladybell, 15 parts of ophiopogon, 15 parts of the dried rhizome of rehmannia, 30 parts of pueraria lobata, 15 parts of the root of bidentate achyranthes.
Embodiment six
The Chinese medicine material includes following components by weight：
25 parts of gypsum, 12 parts of rhizoma anemarrhenae, 26 parts of reed root, 12 parts of selfheal, 12 parts of mulberry leaf, 12 parts of chrysanthemum, 55 parts of radix astragali, north
25 parts of the root of straight ladybell, 12 parts of ophiopogon, 12 parts of the dried rhizome of rehmannia, 26 parts of pueraria lobata, 12 parts of the root of bidentate achyranthes.
Embodiment seven
The Chinese medicine material includes following components by weight：
10 parts of gypsum, 12 parts of rhizoma anemarrhenae, 10 parts of reed root, 12 parts of selfheal, 5 parts of mulberry leaf, 12 parts of chrysanthemum, 30 parts of radix astragali, north are husky
25 parts of ginseng, 5 parts of ophiopogon, 12 parts of the dried rhizome of rehmannia, 5 parts of pueraria lobata, 12 parts of the root of bidentate achyranthes.
Embodiment eight
The Chinese medicine material includes following components by weight：
15 parts of gypsum, 8 parts of rhizoma anemarrhenae, 15 parts of reed root, 8 parts of selfheal, 8 parts of mulberry leaf, 8 parts of chrysanthemum, 40 parts of radix astragali, Radix Glehniae 15
Part, 8 parts of ophiopogon, 8 parts of the dried rhizome of rehmannia, 10 parts of pueraria lobata, 8 parts of the root of bidentate achyranthes.
Embodiment nine
The Chinese medicine material includes following components by weight：
25 parts of gypsum, 8 parts of rhizoma anemarrhenae, 15 parts of reed root, 12 parts of selfheal, 8 parts of mulberry leaf, 12 parts of chrysanthemum, 40 parts of radix astragali, north are husky
25 parts of ginseng, 8 parts of ophiopogon, 12 parts of the dried rhizome of rehmannia, 10 parts of pueraria lobata, 12 parts of the root of bidentate achyranthes.
Embodiment ten
The Chinese medicine material includes following components by weight：
22 parts of gypsum, 10 parts of rhizoma anemarrhenae, 22 parts of reed root, 10 parts of selfheal, 10 parts of mulberry leaf, 10 parts of chrysanthemum, 48 parts of radix astragali, north
20 parts of the root of straight ladybell, 10 parts of ophiopogon, 10 parts of the dried rhizome of rehmannia, 18 parts of pueraria lobata, 10 parts of the root of bidentate achyranthes.
The Chinese medicine composition of above example, in use, with being decocted in water for oral dose after being mixed by Chinese medicine composition；During decoction,
In the case of not influencing this Chinese medicine composition effect, it can be added according to clinical symptoms one or more for improving or treating accompanying symptoms
Chinese medicine, such as swelling of parotid gland plus caulis lonicerae, Radix Isatidis, edible tulip are with swelling and pain relieving；It is vexed rather plus stir-baked FRUCTUS GARDENIAE, lily etc. with
Relieving restlessness that clears away heart-fire；Enuresis nocturna adds Morinda offcinalis How, fructus alpiniae oxyphyllae etc. with kidney tonifying contracting urine etc..
The Chinese medicine can add the acceptable pharmaceutical carrier of medicine and preparation is made；For example particle is made by pharmaceutical carrier
The forms such as agent, oral liquid, tablet, capsule, pill, can be realized using existing commercial process.
The invention also discloses the method that this Chinese medicine composition can take any prior art, and add it is any other into
Point, it is used to prepare the medicine for treating Sjogren syndrome.
It is Chinese medicine composition clinical research situation of the present invention below, shows work of the present invention in Sjogren syndrome treatment
With：
Ordinary circumstance
Clinically selection meets the patient 60 of Sjogren syndrome, 29~65 years old age.It is divided into 2 using random digits table
Group, treatment group 30 is 30~64 years old age, 46.2 ± 11.3 years old average, and the course of disease 6~138 months is 14.25 ± 8.55 months average；
Control group 30,28~65 years old age, 47.4 ± 10.6 years old average, the course of disease 7~127 months is 13.42 ± 7.86 months average.2
Group patient age, the course of disease, state of an illness etc. are statistically analyzed, no significant difference P>0.05, it is comparable.
Diagnostic criteria
Meet the Sjogren syndrome world diagnostic classification standard person of revision in 2002.
1) case standard is included
Voluntarily it is used as study subject；Age between 18~65 years old, men and women；Meet diagnosis of xerosis standard
Person.
2) exclusion standard
1. secondary Sjogren syndrome merges other systems rheumatism immunological disease, such as rheumatoid arthritis, systemic erythema
Lupus etc.) patient；2. there is severe psychiatric disease patient；Put question to 3. avoiding intentionally, incorrect answer a question or mismatch questionnaire
Person.
Therapeutic scheme
Chinese medicine compound prescription of the present invention is given with being decocted in water for oral dose by treatment group, and embodiment one~tri- each 10 is used wherein in treatment group；
During decoction, in the case where not influencing this Chinese medicine composition effect, it can be added according to disease symptoms one or more for improving
Or the Chinese medicine for the treatment of accompanying symptoms, such as swelling of parotid gland plus caulis lonicerae, Radix Isatidis, edible tulip are with swelling and pain relieving；It is vexed rather not add stir-fry Cape jasmine
Son, lily etc. are with relieving restlessness that clears away heart-fire；Enuresis nocturna adds Morinda offcinalis How, fructus alpiniae oxyphyllae etc. with kidney tonifying contracting urine etc., continuous treatment 3 months.
Control group patient gives hydroxychloroquine, Shanghai Zhongxi Pharmaceutical Co., Ltd., 0.2g/ times, 2 times a day.The course for the treatment of is 3
Month, for oral administration, external used medicine of this disease of deactivation other treatment during treatment.
Observation index：
1) observation index：Compare the pretherapy and post-treatment mouth xerophthalmia scheorma fraction of patient, with 10cm horizontal eyesights range estimation ruler method self
Scoring, VAS methods：0 point of inaction, it is serious be 10 points, it is erythrocyte sedimentation rate (ESR), c reactive protein (CRP), immunoglobulin G (IgG), immune
The indexs such as globulin A (IgA), immunoglobulin M (IgM).
2) criterion of therapeutical effect：Reference《New Chinese medicine guideline of clinical investigations》The criterion of the effect of middle formulation.Clinic is slow
Solution：Symptom, sign disappear, and test in laboratory leading indicator (including erythrocyte sedimentation rate, c reactive protein, immunoglobulin etc.) is recovered or connect
Near normal, total mark is reduced before relatively treating>95%；It is effective：Symptom, sign disappear substantially, and laboratory examination leading indicator is obvious
Improve, total mark is reduced before relatively treating<95% but>70%；Effectively：Symptom, sign mitigate, and laboratory examination leading indicator is
Improve, total mark is reduced before relatively treating<70% but>30%；It is invalid：Symptom, sign and lab index are not improved, always
Integration is reduced before relatively treating<30%.
3) safety detection：Blood, urine, feces routine and Liver and kidney function, it is each before and after treatment to record 1 time.
Result of study
Treatment group：Clinical remission 9, effective 14, effective 3, total effective rate 86.7%, control group：Clinical remission 3,
Effective 8, effective 5, total effective rate 53.3%.Two groups of total effective rates have significant difference (p<0.05).
One clinical remission of embodiment 3, effective 5, effective 1, total effective rate 90%；Two clinical remission of embodiment 4, shows
Effect 5, total effective rate 90%；Three clinical remission of embodiment 2, effective 4, effective 2, total effective rate 80%, therefore the present invention with
Embodiment two is excellent.
Chinese medicine compound prescription group mouth xerophthalmia scheorma fraction, erythrocyte sedimentation rate, c reactive protein, immunoglobulin are significantly lower than control group, as a result
It is shown in Table 1,2.The result shows that Chinese medicine compound prescription can be obviously improved Sjogren syndrome symptom, suppression inflammation and humoral immunity effect.
Influence of 1 Chinese medicine compound prescription of table to Sjogren syndrome clinical symptoms and inflammatory parameters
Note：* p compared with the control group<0.05；* p compared with the control group<0.01.
Influence of 2. Chinese medicine compound prescription of table to Sjogren syndrome clinical symptoms immunoglobulin
| Group | n | Time | IgG | IgA | IgM |
| Control group | 30 | Before treatment | 19.57±2.01 | 4.58±0.56 | 2.84±0.24 |
| After treatment | 17.35±1.89 | 4.05±0.39 | 2.64±0.25 | ||
| Treatment group | 30 | Before treatment | 20.17±2.13 | 4.65±0.54 | 2.97±0.31 |
| After treatment | 15.78±1.29* | 3.67±0.24* | 2.41+0.23 |
Note：* p compared with the control group<0.05；* p compared with the control group<0.01.
Safety evaluation result：Treatment group's epigastric discomfort 1, diarrhea 1, the big conventional, biochemical indicator of this group of patient three
It is without exception；Control group epigastric discomfort 2, nausea 2, blurred vision 2, hepatic disorder 1.Two groups of tolerances have bright
Different (the p of significant difference<0.01), treatment group's side effect is significantly lower than control group.
The result shows that：Chinese medicine compound prescription of the present invention has Sjogren syndrome an obvious therapeutic effect, and curative effect is substantially better than pair
According to medicine hydroxychloroquine, while side effect of the present invention is slight, is conducive to long-term use.
Medical record is illustrated：
Example 1：High ××, female, 43 years old.There is dry without obvious inducement in patient, eye is done 2 years, aggravates April, and Mr. Yu, which imparts knowledge to students, to be cured
The wet training of academic and work atmosphere improves coherence check, is diagnosed as Sjogren syndrome, gives after the drug therapy such as Pa Fulin January symptom without substantially changing
It is kind, go to a doctor to seek Chinese medicine on March 7th, 2012, patient's dry eye is done substantially, weak, receive can, it is poor to sleep, defecate
Dilute, red tip of tongue moss thin yellow, arteries and veins is thin.Outer court checks：Blood routine：WBC 12.3×109/ L ↑, RBC 6.49 × 1012/ L ↑, routine urinalysis
(-), humoral immunity：IgG 17.9g/L ↑, IgA, IgM (-), C3、C4(-), ESR (-), CRP (-), ANA (+) 1:100, SS-A
(+), anti-Jo-1 (+).Chinese medical discrimination：Scorching body fluid deficiency, deficiency of both qi and yin, prescription：Gypsum 20g, rhizoma anemarrhenae 5g, reed root 20g, selfheal
5g, mulberry leaf 15g, chrysanthemum 15g, radix astragali 45g, Radix Glehniae 10g, ophiopogon 10g, pueraria lobata 30g, root of bidentate achyranthes 5g, Chinese cassia tree 6g, stop pa by totally 7 doses
Fu Lin.Two examine, and dry has been alleviated, and still weak obvious, it is poor to sleep, and two, pink tongue moss thin yellow is done, deeptensepulse.Prescription：Gypsum
20g, rhizoma anemarrhenae 5g, reed root 20g, selfheal 5g, mulberry leaf 15g, chrysanthemum 15g, radix astragali 60g, Radix Glehniae 10g, ophiopogon 10g, pueraria lobata
30g, root of bidentate achyranthes 5g, dried rhizome of rehmannia 10g, Polygonum multiflower knotweed 30g, Radix Codonopsis 15g, totally 21 doses.Three examine, and mouthful eye is dry is clearly better by patient, still feels easily tired
It is tired, pink tongue tongue Bobai, deep thready pulse.Top Radix Codonopsis dosage is to 30g, corydalis tuber 20g, and hereafter the dialectical plus-minus in side is controlled based on this
Treat 2 months.On September 6th, 2012, check ANA (+), anti-JO-1 (+), blood routine：RBC 6.30×1012/ L ↑, routine urinalysis (-), body
Liquid is immunized：IgG, IgA, IgM (-), C3、C4(-), ESR (-), CRP (-).Patient feels quite pleased curative effect, and interruption takes top plus-minus
Treatment, with chrysanthemum, matrimony vine, ophiopogon, the soaked clothes of the sterculia seed during drug withdrawal.On March 22nd, 2013 blood routine, routine urinalysis (-),
IgG, IgA, IgM (-), C3、C4(-), ESR, CRP (-), check ANA (-), ENA (-), all antibody are turned out cloudy, without obvious mouth
Xerophthalmia shape, to consolidate curative effect, is interrupted above-mentioned check in treatment March These parameters, as a result normal.Withdraw Chinese medicine, it is multiple after half a year
It is without exception to look into associated antibodies.
Example 2：Lee's ××, female, 49 years old, dry half a year repeatedly, aggravated January, and dry synthesis was made a definite diagnosis in outer court before patient January
Sign, medical on 2 20th, 2013, existing dry is obvious, is done with eye, diarrhea, spiritlessness and weakness, easy diseases caused by external factors, vest pain, the fat tongue of pale tongue
Bao Bai, arteries and veins are thin.Patient states the treatment that takes traditional Chinese medicine in the recent period, but dry aggravates after clothes, and analysis prescription is with rhizoma zingiberis, Chinese cassia tree, asarum etc., it is intended to
Warming the spleen for removing fluid-retention.Quarter examines dialectical：The scorching deficiency of Yin, the deficiency of vital energy lose fortune, prescription：Gypsum 30g, rhizoma anemarrhenae 15g, reed root 30g, selfheal 15g, mulberry
Leaf 10g, chrysanthemum 10g, radix astragali 60g, Radix Glehniae 30g, ophiopogon 15g, pueraria lobata 15g, root of bidentate achyranthes 15g, dried rhizome of rehmannia 15g, 7 doses.Two examine, dry
Slightly subtract, diarrhea is good, and after adding and subtracting treatment March with top, it is without exception to look into biochemical indicator, and the disease such as does without obvious mouth eye, withdraws
Chinese medicine, follow-up half a year, stable disease.
Example 3：Xiao ×, female, 46 years old, repeatedly mouth eye do 10 years, with cough 3 years.Patient made a definite diagnosis dry synthesis before 8 years in outer court
Sign, dry cough finds pulmonary interstitial fibrosis to 3 years causes repeatedly.Go to a doctor within 10th in August in 2013, patient mouthful eye is done substantially, and body disappears
It is thin, tired, the dark red no tongue of tongue, thready rapid pulse are breathed heavily after dry cough, activity.Give clearing liver and rush down stomach, nourishing yin to moisten dryness, prescription gypsum 10g, rhizoma anemarrhenae
10g, reed root 10g, selfheal 10g, mulberry leaf 5g, chrysanthemum 5g, radix astragali 30g, Radix Glehniae 20g, ophiopogon 5g, pueraria lobata 10g, root of bidentate achyranthes 10g,
Dried rhizome of rehmannia 5g, curcuma zedoary 15g, safflower 10g.After plus-minus treatment 3 weeks, mouthful eye is dry is relieved by patient, the visible a little white tongue of lingual surface.Continue
Add and subtract and breathe heavily tired improvement after treating March, readme treatment previous minute can only skip rope 20, can now jump 50.Avenged after with top accretion
Glycosides piece treats half a year, checks chest CT, stable disease, with contrasting no significant change the year before.
It can be seen from the above that the present invention is improving Sjogren syndrome exocrine glandular function curative effect affirmative, and it is better than immunodepressant
Therapeutic effect；Clinical practice is safe and effective, the side effect such as no immunodepressant hepatorenal damage, bone marrow suppression；Show the present invention
There is unique advantage in treatment Sjogren syndrome.
Claims (8)
- A kind of 1. Chinese medicine for treating Sjogren syndrome, it is characterised in that：The Chinese medicine material is composed of the following components by weight：10-30 parts of gypsum, 5-15 parts of rhizoma anemarrhenae, 10-30 parts of reed root, 5-15 parts of selfheal, 5-15 parts of mulberry leaf, 5-15 parts of chrysanthemum, Huang 30-60 parts of stilbene, 10-30 parts of Radix Glehniae, ophiopogon 5-15 part, 5-15 parts of the dried rhizome of rehmannia, 5-30 parts of pueraria lobata, 5-15 parts of the root of bidentate achyranthes.
- 2. the Chinese medicine for the treatment of Sjogren syndrome according to claim 1, it is characterised in that：The Chinese medicine material is by weight It is composed of the following components：10-25 parts of gypsum, 5-12 parts of rhizoma anemarrhenae, 10-26 parts of reed root, 5-12 parts of selfheal, 5-12 parts of mulberry leaf, 5-12 parts of chrysanthemum, Huang 30-55 parts of stilbene, 10-25 parts of Radix Glehniae, ophiopogon 5-12 part, 5-12 parts of the dried rhizome of rehmannia, 5-26 parts of pueraria lobata, 5-12 parts of the root of bidentate achyranthes.
- 3. the Chinese medicine for the treatment of Sjogren syndrome according to claim 2, it is characterised in that：The Chinese medicine material is by weight It is composed of the following components：15-25 parts of gypsum, 8-12 parts of rhizoma anemarrhenae, 15-26 parts of reed root, 8-12 parts of selfheal, 8-12 parts of mulberry leaf, 8-12 parts of chrysanthemum, Huang 40-55 parts of stilbene, 15-25 parts of Radix Glehniae, ophiopogon 8-12 part, 8-12 parts of the dried rhizome of rehmannia, 10-26 parts of pueraria lobata, 8-12 parts of the root of bidentate achyranthes.
- 4. the Chinese medicine of Sjogren syndrome is treated according to claim 3, it is characterised in that：The Chinese medicine material by weight by Following components forms：18-25 parts of gypsum, 8-12 parts of rhizoma anemarrhenae, 18-26 parts of reed root, 8-12 parts of selfheal, 8-12 parts of mulberry leaf, 8-12 parts of chrysanthemum, Huang 45-50 parts of stilbene, 18-22 parts of Radix Glehniae, ophiopogon 8-12 part, 8-12 parts of the dried rhizome of rehmannia, 15-22 parts of pueraria lobata, 8-12 parts of the root of bidentate achyranthes.
- 5. the Chinese medicine for the treatment of Sjogren syndrome according to claim 4, it is characterised in that：The Chinese medicine material is by weight It is composed of the following components：22 parts of gypsum, 10 parts of rhizoma anemarrhenae, 22 parts of reed root, 10 parts of selfheal, 10 parts of mulberry leaf, 10 parts of chrysanthemum, 48 parts of radix astragali, Radix Glehniae 20 Part, 10 parts of ophiopogon, 10 parts of the dried rhizome of rehmannia, 18 parts of pueraria lobata, 10 parts of the root of bidentate achyranthes.
- 6. the Chinese medicine of the treatment Sjogren syndrome according to claim 1-5 any claims, it is characterised in that：The Chinese medicine One or more Chinese medicines for being used to improving or treating accompanying symptoms are added during use.
- 7. the Chinese medicine of the treatment Sjogren syndrome according to according to claim 1-5 any claims, it is characterised in that：Should Chinese medicine adds preparation made of the acceptable pharmaceutical carrier of medicine.
- 8. the Chinese medicine of the treatment Sjogren syndrome according to claim 1-5 any claims is preparing the dry synthesis for the treatment of Levy the application in medicine.
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