CN104706348B - A kind of self-calibrating method using multi-mode continuous blood pressure measurer - Google Patents

A kind of self-calibrating method using multi-mode continuous blood pressure measurer Download PDF

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CN104706348B
CN104706348B CN201510125529.0A CN201510125529A CN104706348B CN 104706348 B CN104706348 B CN 104706348B CN 201510125529 A CN201510125529 A CN 201510125529A CN 104706348 B CN104706348 B CN 104706348B
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blood pressure
acquisition module
pwtt
hbr
model
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CN104706348A (en
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王慧泉
乌维磊
庞志翔
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NINGBO MEILINGSI MEDICAL TECHNOLOGY Co Ltd
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NINGBO MEILINGSI MEDICAL TECHNOLOGY Co Ltd
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Measuring for diagnostic purposes; Identification of persons
    • A61B5/24Detecting, measuring or recording bioelectric or biomagnetic signals of the body or parts thereof
    • A61B5/316Modalities, i.e. specific diagnostic methods
    • A61B5/318Heart-related electrical modalities, e.g. electrocardiography [ECG]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Measuring for diagnostic purposes; Identification of persons
    • A61B5/02Detecting, measuring or recording pulse, heart rate, blood pressure or blood flow; Combined pulse/heart-rate/blood pressure determination; Evaluating a cardiovascular condition not otherwise provided for, e.g. using combinations of techniques provided for in this group with electrocardiography or electroauscultation; Heart catheters for measuring blood pressure
    • A61B5/021Measuring pressure in heart or blood vessels
    • A61B5/02141Details of apparatus construction, e.g. pump units or housings therefor, cuff pressurising systems, arrangements of fluid conduits or circuits
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Measuring for diagnostic purposes; Identification of persons
    • A61B5/02Detecting, measuring or recording pulse, heart rate, blood pressure or blood flow; Combined pulse/heart-rate/blood pressure determination; Evaluating a cardiovascular condition not otherwise provided for, e.g. using combinations of techniques provided for in this group with electrocardiography or electroauscultation; Heart catheters for measuring blood pressure
    • A61B5/021Measuring pressure in heart or blood vessels
    • A61B5/022Measuring pressure in heart or blood vessels by applying pressure to close blood vessels, e.g. against the skin; Ophthalmodynamometers
    • A61B5/0225Measuring pressure in heart or blood vessels by applying pressure to close blood vessels, e.g. against the skin; Ophthalmodynamometers the pressure being controlled by electric signals, e.g. derived from Korotkoff sounds
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Measuring for diagnostic purposes; Identification of persons
    • A61B5/103Detecting, measuring or recording devices for testing the shape, pattern, colour, size or movement of the body or parts thereof, for diagnostic purposes
    • A61B5/11Measuring movement of the entire body or parts thereof, e.g. head or hand tremor, mobility of a limb
    • A61B5/1116Determining posture transitions
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Measuring for diagnostic purposes; Identification of persons
    • A61B5/103Detecting, measuring or recording devices for testing the shape, pattern, colour, size or movement of the body or parts thereof, for diagnostic purposes
    • A61B5/11Measuring movement of the entire body or parts thereof, e.g. head or hand tremor, mobility of a limb
    • A61B5/1118Determining activity level

Abstract

The invention discloses a kind of self-calibrating method using multi-mode continuous blood pressure measurer, comprise the following steps:1) blood pressure measuring device is opened, microprocessor (4) starts to gather signal, electrocardiogram acquisition module (1) collection electrocardiosignal, oscillographic method blood pressure acquisition module (2;2 ') BP, pulse wave acquisition module (3) collection pulse wave signal are gathered, microprocessor (4) is calculated PWTT and HBR numerical value, establishes the triangular model of BP, HBR and PWTT;2) cuff type blood pressure detecting device measuring blood pressure is started, and the HBR and PWTT being calculated using the model obtained in step 1) by current measurement value calculate current blood pressure, the pressure value of cuff type blood pressure detecting device measuring and the pressure value being calculated by the existing model of step 1) are compared, until the error between the pressure value that the pressure value and cuff type detection device measurement that are calculated with the model after correction obtain is less than certain threshold value, then the correlation model between BP, HBR and PWTT is successfully established, and BP self-calibrations are completed.

Description

A kind of self-calibrating method using multi-mode continuous blood pressure measurer
Technical field
The present invention relates to a kind of blood pressure measuring device, especially a kind of self-calibration side using blood pressure during this measurement apparatus Method.
Background technology
Blood pressure is one of human body important parameter, reflects that blood circulation is made to unit area vascular wall in the blood vessel in human body Into lateral pressure.Hypertension has become one of most common angiocardiopathy in the whole world, and the prevention of China's emphasis and control One of " three high ".Prevention and control hypertension most effective way are exactly continuous progress blood pressure detecting.Currently used dynamic Blood pressure detecting, it is not really continuous detection, but batch (-type) blood pressure detecting.This method is based on oscillographic method, special at some Measurement pressure value is carved in timing.The blood pressure detecting of this batch (-type), can not only provide continuous blood pressure data, and due to Cuff inflation etc. acts, and can give in rest, the user in especially sleeping brings very big discomfort.
With further research of the people to pulse wave feature, foreign study person refer to utilize pulse wave from nineteen twenty-two Conduction time (PWTT) method is used for noninvasive continuous BP measurement, within the specific limits, linear pass between PWTT and arterial pressure System, for this measuring method, domestic typical patent has the entitled of Application No. 200610002343.7 " to be used to realize blood The patent of the measuring method and system for the pulse transit that pressure continuously measures ", and the title of Application No. 201010602899.6 For the patent of " measuring arterial pressure device and measuring method based on pulse wave signal and electrocardiosignal ".But all do not have in above-mentioned patent Calibration process is referred to, due to the individual difference of measured, the relation between PWTT and arterial pressure is very big in interindividual variation, this A little patents are gone to measure Different Individual with same coefficient of relationship, and the accreditation of clinical indices can not be obtained by causing this technology.
For how to eliminate individual difference and carry out compensation data, domestic applications number be 201110144051.8 it is entitled The patent of " being used for the individual calibration method and device with the continuous Estimation and Measurement arterial pressure of pulse wave " is proposed according to individual Blood pressure situation is demarcated to the coefficient in the sphygmomanometry based on PWTT.But its method can only estimate pressure value, the degree of accuracy It is not high enough;Meanwhile scaling method is the survey for restarting second calibration point blood pressure when PWTT times and last time differ greatly Amount, there is uncertainty in actual use, possibly can not realize the continuous accurate measurement to user's blood pressure.And Application No. The patent of 200410042522.4 entitled " a kind of using compensate automatically without cuff type continuous blood pressure detection method " passes through Measurement some characteristic quantities related to the pulse of measured, with cardiac output, the pressure being tested between position and sensor, fan Walk the factors such as nerve to compensate sphygmomanometer, trimming process is cumbersome, is difficult in practical application.
The detection of blood pressure and the posture of measured have direct relation, the test pose for how to control measured, with MEMS development, acceleration transducer is all added in system by many patents, a source as information compensation.Such as state The patent of entitled " sphygmomanometer system and its blood pressure measuring method " of interior Application No. 201210552217.4, in blood pressure detecting When its angle detected by 3D acceleration transducers simultaneously, determine that measured detects the angle of arm and body, prompt measured Taken multiple measurements with same posture, to reduce the detection error that posture different band is come.In this above-mentioned patent, angular pose Detection is only with aid prompting information, is not participated among the computing of pressure value.And for example Application No. 201310072380.5 Entitled the Interference Suppression System and disturbance restraining method of measurement " be used for sphygmomanometer " patent, tucked inside the sleeve pocket type sphygmomanometer in tradition In add acceleration signal, with the extraction of attitude signal so as to suppress to disturb, this method will input in calculating process The information such as the height of measured, brachium, it is relative complex.It is also relatively simple on 3-axis acceleration information operating, only it is to calculate sky Between in acceleration resultant, actual test is ineffective.
To sum up shown, PWTT methods oscillographic method electronic sphygmomanometer more traditional in principle and operation has very big advantage Exceed, but do not occur the continuous BP measurement equipment based on PWTT of Clinical practice yet at present, mainly due to individual difference, survey The gesture stability of measured and application method cause the relational expression between PWTT and ambulatory blood pressure values unstable during amount, so that The accuracy and reliability for the pressure value that PWTT methods obtain are not high enough.Measurement error caused by the non-normal use of measured, In the use for equally occurring in the electronic sphygmomanometer of traditional oscillographic method, therefore during hospital diagnosis disease, it is necessary to patient again Measure.This " curing from property ", the i.e. non-professionality of measurement process, and the reason for cause tele-medicine to be difficult to it One.
The content of the invention
The technical problems to be solved by the invention are to provide a kind of use multi-mode continuous blood pressure for being easy to individuation to measure The self-calibrating method of measurement apparatus.
Technical scheme is used by the present invention solves above-mentioned technical problem:One kind is filled using multi-mode continuous BP measurement The self-calibrating method put, the multi-mode continuous blood pressure measurer include be used for gather electrocardiosignal electrocardiogram acquisition module, Gather BP oscillographic method blood pressure acquisition module, gather the pulse wave acquisition module of pulse wave signal and for handling the heart The microprocessor for the signal that electric acquisition module, oscillographic method blood pressure acquisition module and pulse wave acquisition module collect, the electrocardio The first Three dimensional motion sensors are provided with acquisition module, being then provided with the second three-dimensional motion in the pulse wave acquisition module senses Device, first Three dimensional motion sensors and the second Three dimensional motion sensors include three dimension acceleration sensor and gyroscope, Characterized in that, the self-calibrating method comprises the following steps:
1) after the unlatching blood pressure measuring device causes start-up operation, it is three-dimensional that the blood pressure measuring device passes through described first Motion sensor and the motion state of the second Three dimensional motion sensors record measured, when the motion state data of record can be sentenced When disconnected measured is in stable state, then the microprocessor prompting starts to gather signal, and the electrocardiogram acquisition module gathers the heart Electric signal, the oscillographic method blood pressure acquisition module gather BP, and the pulse wave acquisition module gathers pulse wave signal, micro- place PWTT and HBR numerical value is calculated by electrocardiosignal and pulse wave signal in reason device;Under same position, collection at least 3 groups of BP, After HBR and PWTT data, the triangular model of BP, HBR and PWTT established under this position;
2) after a period of time, after measured is again introduced into stable state, under this stable same position, start Cuff type blood pressure detecting device measuring blood pressure, and be calculated using the model obtained in step 1) by current measurement value HBR and PWTT calculates current blood pressure, by the pressure value of cuff type blood pressure detecting device measuring and passes through the existing model meter of step 1) Obtained pressure value is compared, if deviation is more than certain threshold value, with the blood pressure of cuff type blood pressure detecting device measuring Value and the pressure value being calculated by the existing model of step 1) re-establish the calibration model between BP and PWTT, HBR, lay equal stress on Duplicate step, until between the pressure value that the pressure value and cuff type detection device measurement that are calculated with the model after correction obtain Error be less than certain threshold value, then the correlation model between BP, HBR and PWTT is successfully established, BP self-calibrations complete.
In the present invention, it is preferred to model have three, wherein according to an aspect of the present invention, in step 1) BP, HBR and The triangular models of PWTT are the linear model established by PLS:
BP=a1PWTT+b1HBR+c1
Wherein, a1、b1And c1PWTT term coefficients, HBR term coefficients and constant compensation item respectively in model.
According to another aspect of the present invention, the triangular model of BP, HBR and PWTT is by neutral net work in step 1) Has the nonlinear model established:
Wherein, a2、b2And c2The weights of PWTT items node, the weights and constant compensation of HBR item nodes respectively in model .
According to another aspect of the present invention, the triangular model of BP, HBR and PWTT is PWTT's and HBR in step 1) Relevant nonlinear model:
BP=a3PWTT*HBR+c3
Wherein, a3And c3The coefficient of PWTT and HBR associations and constant compensation item respectively in model.
The information of the position is obtained by first Three dimensional motion sensors and the second Three dimensional motion sensors, including Refer to the motion state and the arm of measured and the angle of trunk of measured, wherein, the acceleration in Three dimensional motion sensors passes Sensor judges whether user is in relative plateau, and gyro sensor record is when the included angle A information of forearm and trunk.
According to an aspect of the present invention, the electrocardiogram acquisition module is connected by electrode with the body surface of measured, described Oscillographic method blood pressure acquisition module is arm-type blood pressure acquisition module, and the pulse wave acquisition module is finger tip formula, the electrocardiogram acquisition Wireless telecommunications between module, oscillographic method blood pressure acquisition module and pulse wave acquisition module.
According to another aspect of the present invention, this measurement apparatus is integrated form, the electrocardiogram acquisition module, oscillographic method blood pressure Acquisition module and pulse wave acquisition module are integrated in wrist-watch devices, and the oscillographic method blood pressure acquisition module is that wrist blood pressure is adopted Collect module, the electrocardiogram acquisition module guides to the trunk of measured by conducting wire, and first Three dimensional motion sensors integrate On the conducting wire.
Preferably, the microprocessor can be independent module, or can also be respectively arranged at the electrocardiogram acquisition In module, oscillographic method blood pressure acquisition module and pulse wave acquisition module.
Compared with prior art, the advantage of the invention is that:Based on PWTT general principles, by the heart rate of measured, motion The factors such as the angle of state, arm and trunk take into account the correlation model established between BP, HBR and PWTT, form personalized mould Type, so that the pressure value that this measurement apparatus obtains for personal user's measurement is more and more accurate, it is more and more stable.
Brief description of the drawings
Fig. 1 is the block diagram of blood pressure measuring device one embodiment of the present invention;
Fig. 2 is the block diagram of second embodiment of blood pressure measuring device of the present invention.
Embodiment
The present invention is described in further detail below in conjunction with accompanying drawing embodiment.
Embodiment one
Referring to Fig. 1, a kind of multi-mode continuous blood pressure measurer, including for gathering the electrocardiogram acquisition module of electrocardiosignal 1st, the oscillographic method blood pressure acquisition module 2 of arterial pressure (BP) and the pulse wave acquisition module 3 of collection pulse wave signal are gathered, its In, oscillographic method blood pressure acquisition module 2 is arm-type, and pulse wave acquisition module 3 is arranged on measured's finger tip.In electrocardiogram acquisition module The first Three dimensional motion sensors 11 are provided with 1, and oscillographic method blood pressure acquisition module 2 is the offer power supply of pulse wave acquisition module 3, The second Three dimensional motion sensors 31 are then provided with pulse wave acquisition module 3.
Electrocardiogram acquisition module 1 is connected by electrode with the body surface of measured, detects the electrocardiosignal of measured;Oscillographic method blood Pressure acquisition module 2 is based on oscillographic method, measures the arterial pressure information of measured, it is gentle that it is integrated with baroceptor, magnetic valve The parts such as pump;Pulse wave acquisition module 3 passes through photoelectric method or pressure application, the noninvasive pulse wave signal for obtaining measured.And two Three dimensional motion sensors module, is made up of three dimension acceleration sensor and gyroscope, for judge measured motion state and Body posture.The first Three dimensional motion sensors 11 being wherein placed in electrocardiogram acquisition module 1 are typically in trunk position, and are placed in The second Three dimensional motion sensors 31 in pulse wave acquisition module 3 are typically in arm position, calculate its absolute angle with ground Degree and acceleration, can learn the motion state of measured, such as walking, running, jump, wave or static, and two three-dimensionals Motion sensor compares its angle over the ground relatively, can learn the body posture of measured, refer to arm and trunk in the present invention Relative position, reflection index can be the included angle A of arm and trunk.
It is connected between above three acquisition module by wireless transmission method and is communicated, will be uniformly processed after data summarization. In addition, above-mentioned each acquisition module can be independent be provided with microprocessor 4, can also unify set a microprocessor 4, processing converge The data of the General Logistics Department, control above-mentioned each acquisition module.The electrocardiosignal that microprocessor 4 can record the collection of electrocardiogram acquisition module 1 is special Decision time PWTT between the pulse wave signal characteristic point that sign point and pulse wave acquisition module 3 gather.Two three-dimensional motions pass Whether the movement state information that sensor measures carries out blood pressure measurement for the decision-making of microprocessor 4, and the relative position information measured, A variable in then being measured as multi-mode, arterial pressure is demarcated for microprocessor 4.
Correlation model be present between PWTT, heart rate (HBR), position (Position) and arterial pressure (BP):
BP=f (PWTT, HBR, Position)
Wherein, Position is position information when measurement occurs, and passes through the first Three dimensional motion sensors 11 and the 2nd 3 Dimension motion sensor 31 obtains, and refers specifically to the position relationships such as motion state and the included angle A of arm and trunk of measured, three maintenance and operations Acceleration transducer in dynamic sensor judges whether user is in relative plateau, and gyro sensor record works as remote holder The included angle A information of arm and trunk.Thus by the position information in detection process, as one-dimensional useful information, reasonably it is added to Continuous blood pressure detection process.
The blood pressure self-calibrating method of above-mentioned multi-mode continuous blood pressure measurer, comprises the following steps:
1) when measured wears the measurement apparatus of the present invention and start to allow its work after, it is three-dimensional that measurement apparatus passes through first The Three dimensional motion sensors 31 of motion sensor 11 and second record the motion state of measured.Plateau is before measuring blood pressure Carry, when the motion state data of record can interpolate that measured is in metastable state, then the prompting of microprocessor 4 starts to adopt Collection standard blood simultaneously records corresponding information, the three-dimensional motion sensing module joint-detection on arm and trunk, judges measured's hand After the angle of arm and trunk is correct, in measured under same smoothly condition (same position information), start to open Dynamic oscillographic method blood pressure acquisition module 2, while continue to record electrocardio and pulse wave signal, and PWTT is calculated by microprocessor 4 With HBR numerical value.At least 3 are gathered respectively by electrocardiogram acquisition module 1, oscillographic method blood pressure acquisition module 2 and pulse wave acquisition module 3 After group data, the triangular correlation model of BP, HBR and PWTT established under this position is currently available that model mainly by following Three kinds:
BP=a1PWTT+b1HBR+c1 (1)
BP=a3PWTT*HBR+c3 (3)
Wherein model form (1) is by the linear model of PLS foundation, a1、b1And c1Respectively in model PWTT term coefficients, HBR term coefficients and constant compensation item;Model form (2) is the nonlinear model established by neutral net instrument, a2、b2And c2The weights and constant compensation item of the weights of PWTT items node, HBR item nodes respectively in model;Model form (3) For PWTT and HBR relevant nonlinear model, a3And c3The coefficient and constant compensation of PWTT and HBR associations respectively in model .
Due to acquiring three groups of data, therefore each corresponding coefficient under current position can be determined by this three groups of data, from And the triangular model of BP, HBR and PWTT is determined, BP can be obtained by HBR and PWTT according to the model when hereafter measuring blood pressure.
2) after a period of time, after measured is again introduced into stable state, equally under this stable position, start Cuff type blood pressure detecting device measuring blood pressure, and blood pressure is calculated by HBR and PWTT using the model obtained in step 1), it will tuck inside the sleeve The pressure value of belt blood pressure detecting device measuring and the pressure value being calculated by existing model are compared, if deviation compared with Greatly, if deviation is more than certain threshold value, the correction between BP and PWTT, HBR is re-established with the two blood pressure test results Model, duplicate step of laying equal stress on, until the pressure value being calculated with the model after correction obtains with cuff type detection device measurement Pressure value between error be less than certain threshold value, model is successfully established, BP self-calibrations complete.
After long period use, measurement apparatus understands start by set date or starts single check and correction by user, by connecting oscillography Method sphygmomanometer measures oscillographic method pressure value, constantly optimizes calibration model, realizes continuous self study.
After model is successfully established, oscillographic method blood pressure acquisition module 2 can not be worn, it is noiseless, noninductive automatically by PWTT methods Collection user's pressure value, for continuous BP measurement.
Wherein, if when blood pressure is demarcated, if user keeps same posture as far as possible, based under more mould parameters such as PWTT Blood pressure measurement model can be established comparatively fast.
User can obtain measuring blood pressure by transferring the data stored in microprocessor 4 or other information storaging medium Time, pressure value, and the auxiliary information such as physical motion state during measurement and corresponding heart rate helps user or specialty Medical worker more comprehensively understands blood pressure conditions and measuring environment of measured etc..
Same measured model corresponding under different positions is also not necessarily identical, and position information has acceleration sensing Device feeds back to obtain, and after measured changes different positions, also can carry out demarcation by above-mentioned two step and establish model, this is laggard The corresponding blood pressure measurement of row.And model form of the present invention is not limited to three of the above model, according to BP and PWTT And relation between HBR and modeling process are likely to occur new model form.
The model phase of establishing can be initiated blood pressure demarcation measurement by user, can also initiate mark automatically according to the state of user Location survey amount;The automatic Calibration time be usually chosen to early morning get up after, a.p after, supper is front and rear and sleep before, these time points can Judged by the real-time clock module in two three-dimensional motion sensing modules and microprocessor 4.
Embodiment two
In the present embodiment, the difference with above-described embodiment one is, the integrated watch that the present embodiment uses Formula equipment, above-mentioned electrocardiogram acquisition module 1, oscillographic method blood pressure acquisition module 2 ' and pulse wave acquisition module 3 are integrated in a watch In the equipment of formula, now, oscillographic method blood pressure acquisition module 2 ' uses wrist.Electrocardiogram acquisition module 1 wherein in wrist-watch devices Need to guide on line 12 to arrive trunk specified location, gather difference electrocardiosignal, the first three-dimensional motion biography is integrated with conducting wire 12 Sensor 11, gather trunk motion state and angle.
During data scaling, corresponding blood pressure data is gathered by blood pressure module in watch, other modules collection heart rate, Posture and PWTT data, and calibration model is established by neutral net fast algorithm;After model is established, showing in watch Ripple method blood pressure module 2 ' is not restarted typically, you can realizes the continuous BP measurement under whole day stable state, monitors whole day blood pressure Change.
Daily early morning, can be by the oscillographic method blood pressure module 2 ' in watch when device detects that user is in stable state Meeting automatic start once, gathers pressure value and simultaneously mutually handled with original model, so as to update original model, realizes and this individual is worked as The foundation of it personalized model.If things go on like this, the system progressively sets up one surely by continuous self study for user Fixed, accurate personalized model and acquisition strategies, effective monitoring is provided for the personal health of user.

Claims (8)

1. a kind of self-calibrating method using multi-mode continuous blood pressure measurer, the multi-mode continuous blood pressure measurer bag Include for gather electrocardiosignal electrocardiogram acquisition module (1), gather BP oscillographic method blood pressure acquisition module (2;2 ') pulse, is gathered The pulse wave acquisition module (3) of ripple signal and for handling the electrocardiogram acquisition module (1), oscillographic method blood pressure acquisition module (2;2 ') and the microprocessor (4) of signal that collects of pulse wave acquisition module (3), set in the electrocardiogram acquisition module (1) There are the first Three dimensional motion sensors (11), the second Three dimensional motion sensors (31) be then provided with the pulse wave acquisition module (3), First Three dimensional motion sensors (11) and the second Three dimensional motion sensors (31) include three dimension acceleration sensor and top Spiral shell instrument, it is characterised in that the self-calibrating method comprises the following steps:
1) after the unlatching blood pressure measuring device causes start-up operation, the blood pressure measuring device passes through first three-dimensional motion Sensor (11) and the motion state of the second Three dimensional motion sensors (31) record measured, when the motion state data energy of record When enough judging that measured is in stable state, then microprocessor (4) prompting starts to gather signal, the electrocardiogram acquisition module (1) electrocardiosignal, the oscillographic method blood pressure acquisition module (2 are gathered;2 ') BP, pulse wave acquisition module (3) collection are gathered PWTT and HBR numerical value is calculated by electrocardiosignal and pulse wave signal in pulse wave signal, the microprocessor (4);Same Under position, after gathering at least 3 groups of BP, HBR and PWTT data, the triangular model of BP, HBR and PWTT established under this position;
2) after a period of time, after measured is again introduced into stable state, under this stable same position, cuff is started Formula blood pressure detecting device measuring blood pressure, and the HBR that is calculated using the model obtained in step 1) by current measurement value and PWTT calculates current blood pressure, is calculated by the pressure value of cuff type blood pressure detecting device measuring and by the existing model of step 1) Pressure value be compared, if deviation is more than certain threshold value, with the pressure value of cuff type blood pressure detecting device measuring and logical Cross the pressure value that the existing model of step 1) has been calculated and re-establish calibration model between BP and PWTT, HBR, duplicate of laying equal stress on step Suddenly, up to the error between the pressure value that the model after with correction is calculated and the pressure value that cuff type detection device measurement obtains Less than certain threshold value, then the correlation model between BP, HBR and PWTT is successfully established, and BP self-calibrations are completed.
2. self-calibrating method as claimed in claim 1, it is characterised in that:The triangular model of BP, HBR and PWTT in step 1) For the linear model established by PLS:
BP=a1PWTT+b1HBR+c1
Wherein, a1、b1And c1PWTT term coefficients, HBR term coefficients and constant compensation item respectively in model.
3. self-calibrating method as claimed in claim 1, it is characterised in that:The triangular model of BP, HBR and PWTT in step 1) For the nonlinear model established by neutral net instrument:
<mrow> <mi>B</mi> <mi>P</mi> <mo>=</mo> <mfrac> <msub> <mi>a</mi> <mn>2</mn> </msub> <mrow> <mn>1</mn> <mo>+</mo> <msup> <mi>e</mi> <mrow> <mo>-</mo> <mi>P</mi> <mi>W</mi> <mi>T</mi> <mi>T</mi> </mrow> </msup> </mrow> </mfrac> <mo>+</mo> <mfrac> <msub> <mi>b</mi> <mn>2</mn> </msub> <mrow> <mn>1</mn> <mo>+</mo> <msup> <mi>e</mi> <mrow> <mo>-</mo> <mi>H</mi> <mi>B</mi> <mi>R</mi> </mrow> </msup> </mrow> </mfrac> <mo>+</mo> <msub> <mi>c</mi> <mn>2</mn> </msub> </mrow>
Wherein, a2、b2And c2The weights and constant compensation item of the weights of PWTT items node, HBR item nodes respectively in model.
4. self-calibrating method as claimed in claim 1, it is characterised in that:The triangular model of BP, HBR and PWTT in step 1) For PWTT and HBR relevant nonlinear model:
BP=a3PWTT*HBR+c3
Wherein, a3And c3The coefficient of PWTT and HBR associations and constant compensation item respectively in model.
5. self-calibrating method as claimed in claim 1, it is characterised in that:The information of the position passes through the one or three maintenance and operation Dynamic sensor (11) and the second Three dimensional motion sensors (31) obtain, including refer to the motion state of measured and the arm of measured With the angle (A) of trunk.
6. self-calibrating method as claimed in claim 1, it is characterised in that:The electrocardiogram acquisition module (1) passes through electrode and quilt The body surface of survey person is connected, and the oscillographic method blood pressure acquisition module (2) is arm-type blood pressure acquisition module, the pulse wave acquisition module (3) it is finger tip formula, between the electrocardiogram acquisition module (1), oscillographic method blood pressure acquisition module (2) and pulse wave acquisition module (3) Wireless telecommunications.
7. self-calibrating method as claimed in claim 1, it is characterised in that:The electrocardiogram acquisition module (1), oscillographic method blood pressure are adopted Collection module (2 ') and pulse wave acquisition module (3) are integrated in wrist-watch devices, and the oscillographic method blood pressure acquisition module (2 ') is Wrist blood pressure acquisition module, the electrocardiogram acquisition module (1) guide to the trunk of measured by conducting wire (12), and the described 1st Dimension motion sensor (11) is integrated on the conducting wire (12).
8. such as self-calibrating method according to any one of claims 1 to 7, it is characterised in that:The microprocessor (4) is independent Module or be respectively arranged at the electrocardiogram acquisition module (1), oscillographic method blood pressure acquisition module (2;2 ') and pulse wave gathers mould In block (3).
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