CN104705326A - Sterilizing composition containing zhongshengmycin and copper (succinate+glutarate+adipate) - Google Patents
Sterilizing composition containing zhongshengmycin and copper (succinate+glutarate+adipate) Download PDFInfo
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- CN104705326A CN104705326A CN201510114222.0A CN201510114222A CN104705326A CN 104705326 A CN104705326 A CN 104705326A CN 201510114222 A CN201510114222 A CN 201510114222A CN 104705326 A CN104705326 A CN 104705326A
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Abstract
The invention discloses a sterilizing composition containing zhongshengmycin and copper (succinate+glutarate+adipate). The sterilizing composition comprises the following effective constituents: zhongshengmycin and copper(succinate+glutarate+adipate), wherein the ratio of zhongshengmycin to copper(succinate+glutarate+adipate) in parts by weight is 1:10 to 10:1; the weight percentage of the weight sum of zhongshengmycin and copper(succinate+glutarate+adipate) in the composition is 4-97%. The sterilizing composition can be processed into one of a suspending agent, a water dispersible granule, a concentrated emulsion, a microemulsion and wettable powder, is excellent in prevention and control on agricultural bacterial diseases, plays a remarkable synergistic interaction role, and further reduces the usage amount of the pesticide.
Description
Technical field
The present invention relates to agricultural bactericidal composition and application thereof, specifically a kind of bactericidal composition that is active ingredient with Zhongshengmycin and tiger glue adipic acid copper, is applied to control agricultural bacterial evil.
Background technology
Zhongshengmycin, English name: zhongshengmycin, being N-sugar tobramycin antibiotic, by suppressing the peptide bond of pathogenetic bacteria protein to generate, finally causing bacterial death.It not only can Antifungi mycelia growth, suppress the sprouting of spore, play the effect of control fungal disease, the generation of the precursor substance of protective plant protecting agent and lignin in all right stimulating plant body, thus improve the resistance against diseases of plant, Zhongshengmycin can resisting gram-positive, negative bacteria, mycobacterium, saccharomycete and filamentous fungi, especially to crops pathogenic bacteria as dish Bacteria erwinia, avenae subsp.citrull, Xanthomonas oryzae, ring rot of apple germ, fusarium graminearum etc.
Tiger glue adipic acid copper, English name: copper, tiger glue adipic acid copper is the mixture of succinic acid copper, glutaric acid copper, adipic acid copper, belong to organic copper bactericide, tiger glue adipic acid copper, mainly through the exchange such as potassium ion, hydrogen ion on copper ion and cause of disease mycoderm surface, makes protein coagulating on pathogen cell membrane, part copper ion penetrates in pathogen cell and combines with some acid simultaneously, affect the activity of enzyme, play bactericidal action, respond well to cucumber bacterial angular leaf spot, citrus bacterial canker disease etc.
Bacterial angular leaf spot is the common bacterial disease of cucumber one class, and sick blade back portion scab often overflows bacterial ooze, perforation, and sugar-preserved gourd is injured frowziness.Soft rot of cabbage is the common bacterial disease of Chinese cabbage one class, and the normal deliquescing of diseased plant basal part of stem is rotted, and gives out a foul smell.The medicine agriculturally preventing and treating bacterial disease cans be counted on one's fingers, and uses same medicine to cause germ to develop immunity to drugs throughout the year.
Different pesticide species composition carries out composite, is the common methods of preventing and treating agriculture resistance disease.The present inventor is on the basis of a large amount of indoor virulences and field medicine effect test, the compounded formula screening of Zhongshengmycin and tiger glue adipic acid copper is conducted in-depth research, find that Zhongshengmycin and tiger glue adipic acid copper carry out composite, in certain proportion, there is obvious synergistic function, and to cucumber bacterial angular leaf spot, soft rot of cabbage, there is outstanding control efficiency, after further study, the present invention is completed.
Summary of the invention
The object of the present invention is to provide a kind of efficient, low toxicity, low cost, quick-acting are good, the lasting period is long, to crop safety, environment amenable agricultural bactericidal composition, is applied to and prevents and treats cucumber bacterial angular leaf spot, soft rot of cabbage.
Technical scheme: a kind of bactericidal composition, effective ingredient is Zhongshengmycin and tiger glue adipic acid copper, the parts by weight ratio of Zhongshengmycin and tiger glue adipic acid copper is 1:10 ~ 10:1, Zhongshengmycin and tiger glue adipic acid weight of copper summation percentage by weight are in the composition 4% ~ 97%, and all the other are pesticidal preparations auxiliary element.
Bactericidal composition of the present invention according to well known to a person skilled in the art method, can be processed into the application forms of the applicable agricultural uses such as suspending agent, water dispersible granules, aqueous emulsion, microemulsion, wetting powder.
Bactericidal composition of the present invention is also containing the auxiliary element of preparation needed for pesticidal preparations, comprise one or more mixing in emulsifier, wetting agent, stabilizing agent, dispersant, thickener, defoamer, antifreezing agent, disintegrant, binding agent, filler, filler, medium etc., be known substance, various auxiliary agents conventional in pesticidal preparations, can change to some extent according to different situations, be not particularly limited.
Bactericidal composition described in the invention, can finished product preparation form provide, namely in composition, each material mixes, and the composition of composition also can provide by unit dose form, directly mixes in bucket or tank, be then diluted to desired concn before using.
Bactericidal composition described in the invention, for preventing and treating agricultural bacterial evil, especially cucumber bacterial angular leaf spot, soft rot of cabbage.
Bactericidal composition described in the invention, usually adopts the method for spraying to use, also can adopt other operation technique agriculturally applied as required.
Bactericidal composition described in the invention has following beneficial effect:
1, Zhongshengmycin and tiger glue adipic acid copper is composite has beyond thought synergistic function, is used alone the control efficiency that improve disease than single dose;
2, Zhongshengmycin and the tiger glue adipic acid copper mechanism of action different, the generation of disease drug resistance can be delayed;
3, Zhongshengmycin and tiger glue adipic acid copper two kinds of active ingredients composite, decrease Pesticide use amount, reduce use cost and alleviate pollution to environment.
Embodiment
In order to make object of the present invention, technical scheme and advantage more short and sweet, the following specific embodiment of the present invention is described, but the present invention is only limitted to absolutely not these examples.The following stated is only the good embodiment of the present invention, only for describing the present invention, can not be interpreted as the restriction to scope of the present invention.It should be pointed out that all any amendments done within the spirit and principles in the present invention, equivalent replacement and improvement etc., all should be included within protection scope of the present invention.Therefore, the protection domain of patent of the present invention should be as the criterion with claims.
In these embodiments, unless otherwise indicated, all percentage is all weight percentage.
Being undertaken composite by dissimilar pesticide active ingredient, is a kind of effective means solving the problem such as use cost and pesticide resistance in agricultural chemicals single dose application process at present.After dissimilar pesticide active ingredient mixture, usually show three kinds of type of action, i.e. summation action, synergistic effect, antagonism.The present inventor, on the basis that a large amount of indoor and outdoors biometric is tested, finds that Zhongshengmycin and tiger glue adipic acid copper are within the scope of certain mixed ratio, have significant synergies to cucumber bacterial angular leaf spot, soft rot of cabbage.
Example of formulations 1:30% Zhongshengmycin tiger glue adipic acid copper suspending agent
Take 5% Zhongshengmycin, 25% tiger glue adipic acid copper, 8% sodium lignin sulfonate, 2.5%OP-10 (alkylphenol polyoxyethylene), 1%CMC (carboxymethyl cellulose), 0.02% organic silicone, 2% glycerine, deionized water complements to 100%.Above-mentioned raw materials, through mixing, after high speed shear dispersion 30min, obtains 30% Zhongshengmycin tiger glue adipic acid copper suspending agent with after skin grinder grinding.
Example of formulations 2:35% Zhongshengmycin tiger glue adipic acid copper microemulsion
Take 8% Zhongshengmycin, 27% tiger glue adipic acid copper, 15% phenethyl phenol polyethenoxy ether and agriculture breast 34#, 5% isopropyl alcohol, 10% dimethylbenzene, 10%N, dinethylformamide, after abundant stirring and dissolving, deionized water complements to 100%, continue to be stirred to transparent, obtained 35% Zhongshengmycin tiger glue adipic acid copper microemulsion.
Example of formulations 3:20% Zhongshengmycin tiger glue adipic acid aqueous emulsion of copper
Take 5% Zhongshengmycin, 15% tiger glue adipic acid copper, 4% phenethyl phenol polyethenoxy ether, 4% alkylbenzenesulfonate, 3%C
3-C
6alcohol, 2% glycerine, 0.5% gum Arabic, 0.4% silicone oil, deionized water adds to 100% weight portion.Above-mentioned raw materials is through mixing, and high speed shear emulsification obtains 20% Zhongshengmycin tiger glue adipic acid aqueous emulsion of copper.
Example of formulations 4:33% Zhongshengmycin tiger glue adipic acid copper wetting powder
Take 3% Zhongshengmycin, 30% tiger glue adipic acid copper, 5% pulls open powder, 5% naphthalenesulfonate formaldehyde condensation compound, 10% talcum powder, kaolin adds to 100% weight portion.Above-mentioned raw materials, through mixing, obtains 33% Zhongshengmycin tiger glue adipic acid copper wetting powder after air-flow crushing.
Example of formulations 5:50% Zhongshengmycin tiger glue adipic acid copper water dispersion granula
Take 10% Zhongshengmycin, 40% tiger glue adipic acid copper, 5% mineral oil, 5% polyoxyethylene nonylphenol ether, the fast T of 5% bleeding agent, 2% lauryl sodium sulfate, 5% sodium lignin sulfonate, 4% naphthalene sulfonate, bentonite adds to 100% weight portion.Above-mentioned raw materials is through mixing, ultra micro air-flow crushing, mixing, the obtained 50% Zhongshengmycin tiger glue adipic acid copper water dispersion granula of granulation.
Assays Example 1: Zhongshengmycin and tiger glue adipic acid copper are to the indoor joint toxicity measuring of cucumber bacterial angular leaf spot bacterium, Erwinia carotorora
Test medicine adopts 5% Zhongshengmycin wetting powder and 30% tiger glue adipic acid copper wetting powder.
With reference to " pesticide bioactivity evaluates SOP ", raw survey standard method NY/T1156.16-2008 and NY/T1156.6-2006.Adopt turbidity method: the cucumber bacterial angular leaf spot bacterial classification of the growth of cultivating in advance in NA medium slant, soft rot of cabbage bacterial classification being diluted with sterile water is respectively 1 × 10
7the suspension of individual spore/mL concentration, inoculates 100 μ L bacterium liquid respectively in the NB medium treatment of each pastille, and vibrate at being placed in 28 DEG C (120r/min) cultivates, and often 4 repetitions are established in process.Measure the turbidity of each process respectively before starting to cultivate, when control treatment reaches exponential phase, measure and record the turbidity of each process.
According to survey data, calculate the growth inhibition ratio of bacterium, represent with percentage (%) by formula (1), result of calculation retains 2 significant digits.
In formula:
P----growth inhibition ratio;
A
0----blank turbidity value added;
A
1----chemicals treatment turbidity value added.
Synegism evaluation method surveys standard method NY/T1156.6-2006 with reference to raw, the synergistic effect of pharmacy mix is evaluated according to the co-toxicity coefficient method (CTC) of Sun & Johnson (1960), namely CTC≤80 are antagonism, 80<CTC<120 is summation action, and CTC >=120 are synergistic effect.
The percentage composition of the toxicity index × 100 mixture Chinese medicine of the percentage composition+medicament B of A medicament in toxicity index × 100 mixture of theoretical toxicity index (the TTI)=medicament A of mixture
All test datas all adopt DPS statistical software to analyze.The growth inhibition ratio (%) of bacterium is calculated according to test data, and be independent variable x with the logarithm value of drug concentration (mg/L), with the growth inhibition ratio of bacterium for dependent variable y, obtain virulence regression equation formula, correlation coefficient (r), EC
50and EC
90and 95% confidence limit.
As can be seen from Table 1 and Table 2, Zhongshengmycin and tiger glue adipic acid copper composite in the scope of 1:10 ~ 10:1 time, co-toxicity coefficient (CTC) is all greater than 120, all shows synergistic function to cucumber bacterial angular leaf spot bacterium, Erwinia carotorora.Wherein, Zhongshengmycin and tiger glue adipic acid copper are with the ratio mixture of 1:10, the highest to the co-toxicity coefficient of cucumber bacterial angular leaf spot bacterium and Erwinia carotorora, visible Zhongshengmycin and tiger glue adipic acid copper is composite has reasonability and feasibility.
Table 1, indoor joint toxicity measuring result to cucumber bacterial angular leaf spot bacterium
Table 2, indoor joint toxicity measuring result to Erwinia carotorora
Assays Example 2: to the field control effectiveness test of cucumber bacterial angular leaf spot
Bactericidal composition of the present invention is positioned at cucumber garden, Chen Jiang town, Huizhou to cucumber bacterial angular leaf spot test site.In the dispenser of cucumber bacterial angular leaf spot initial stage of origination, adopt spray-on process dispenser, adopt 5% Zhongshengmycin wetting powder, 30% tiger glue adipic acid copper wetting powder medicament in contrast, 7 chemicals treatment are established in test altogether, and each process repeats for 3 times.Cornerwise five somes investigation in district diseased plant number is managed throughout, often some investigation 20 strain cucumber before dispenser.Within after dispenser 3 days, 7 days, 14 days, respectively investigate a control efficiency, record diseased plant number, and calculate control efficiency, result of the test is as shown in table 3.
Table 3, Zhongshengmycin and tiger glue adipic acid copper mixture prevent and treat the result of the test of angular leaf spot of cucumber
As can be seen from Table 3 all will apparently higher than Zhongshengmycin wetting powder and the 30% tiger glue adipic acid copper wetting powder same period 5% to the preventive effect of cucumber bacterial angular leaf spot after Zhongshengmycin and tiger glue adipic acid copper composite 3d, 7d, 14d, the preventive effect to cucumber bacterial angular leaf spot can be improved compared with illustrating that Zhongshengmycin and tiger glue adipic acid copper are composite and being used alone with two kinds of single doses, after medicine, 14d preventive effect still reaches more than 80% simultaneously, illustrate to have good lasting effect, duration of test does not find that this compound drug produces poisoning to cucumber.
Assays Example 3: to the field control effectiveness test of soft rot of Chinese cabbage
Bactericidal composition of the present invention is positioned at Chinese cabbage garden, Chen Jiang town, Huizhou to soft rot of cabbage test site.In the dispenser of soft rot of cabbage initial stage of origination, adopt spray-on process.Adopt 5% Zhongshengmycin wetting powder, 30% tiger glue adipic acid copper wetting powder medicament in contrast, 7 chemicals treatment are established in test altogether, and each process repeats for 3 times.Cornerwise five somes investigation in district diseased plant number is managed throughout, often some investigation 20 strain Chinese cabbages before dispenser.Within after dispenser 3 days, 7 days, 14 days, respectively investigate a control efficiency, record diseased plant number, and calculate control efficiency, result of the test is as shown in table 4.
Table 4, Zhongshengmycin and tiger glue adipic acid copper mixture prevent and treat the result of the test of soft rot of cabbage
As can be seen from Table 4 all will apparently higher than Zhongshengmycin wetting powder and the 30% tiger glue adipic acid copper wetting powder same period 5% to the preventive effect of soft rot of Chinese cabbage after Zhongshengmycin and tiger glue adipic acid copper composite 3d, 7d, 14d, the preventive effect to Chinese cabbage bacterial slimy soft rot can be improved compared with illustrating that Zhongshengmycin and tiger glue adipic acid copper are composite and being used alone with two kinds of single doses, after medicine, 14d preventive effect still reaches more than 80% simultaneously, illustrate to have good lasting effect, duration of test does not find that this compound drug produces poisoning to Chinese cabbage.
In sum, bactericidal composition of the present invention, compared with existing unitary agent, not only have obvious synergistic effect, also have good bactericidal effect, the lasting period is long, to Crop securify, can reduce dosage, is worth applying in agricultural production.
Claims (4)
1. one kind contains the bactericidal composition of Zhongshengmycin and tiger glue adipic acid copper, it is characterized in that: active ingredient is Zhongshengmycin and tiger glue adipic acid copper, ratio of weight and number 1:10 ~ the 10:1 of Zhongshengmycin and tiger glue adipic acid copper, Zhongshengmycin and tiger glue adipic acid weight of copper summation percentage by weight are in the composition 4% ~ 97%.
2. a kind of bactericidal composition containing Zhongshengmycin and tiger glue adipic acid copper according to claim 1, is characterized in that: its formulation is suspending agent, water dispersible granules, aqueous emulsion, microemulsion or wetting powder.
3. a kind of bactericidal composition containing Zhongshengmycin and tiger glue adipic acid copper according to claim 1 is for preventing and treating the application in agricultural bacterial evil.
4. a kind of bactericidal composition containing Zhongshengmycin and tiger glue adipic acid copper according to claim 3, is characterized in that: described agricultural bacterial evil is cucumber bacterial angular leaf spot and soft rot of cabbage.
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Cited By (4)
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| CN106614545A (en) * | 2016-12-23 | 2017-05-10 | 江西天祥通用航空股份有限公司 | Oil suspending agent and application thereof in preventing and treating agricultural bacterial diseases |
| CN106689202A (en) * | 2015-07-20 | 2017-05-24 | 江苏龙灯化学有限公司 | Bactericidal composition |
| CN107347878A (en) * | 2017-07-21 | 2017-11-17 | 江西天祥通用航空股份有限公司 | A kind of suspending agent and its application in bacterial diseases of crops is prevented and treated |
| CN110973143A (en) * | 2019-09-18 | 2020-04-10 | 北京宇悦生物科技有限公司 | Bactericide composition and application thereof |
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| CN1729791A (en) * | 2005-08-25 | 2006-02-08 | 齐军山 | Agricultural sterilizing composition aimed at plant disease |
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Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106689202A (en) * | 2015-07-20 | 2017-05-24 | 江苏龙灯化学有限公司 | Bactericidal composition |
| CN106689202B (en) * | 2015-07-20 | 2019-11-22 | 江苏龙灯化学有限公司 | A kind of bactericidal composition |
| CN106614545A (en) * | 2016-12-23 | 2017-05-10 | 江西天祥通用航空股份有限公司 | Oil suspending agent and application thereof in preventing and treating agricultural bacterial diseases |
| CN107347878A (en) * | 2017-07-21 | 2017-11-17 | 江西天祥通用航空股份有限公司 | A kind of suspending agent and its application in bacterial diseases of crops is prevented and treated |
| CN110973143A (en) * | 2019-09-18 | 2020-04-10 | 北京宇悦生物科技有限公司 | Bactericide composition and application thereof |
| CN110973143B (en) * | 2019-09-18 | 2022-01-07 | 北京宇悦生物科技有限公司 | Bactericide composition and application thereof |
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