CN104688973A - Traditional Chinese medicine preparation for treating insomnia - Google Patents
Traditional Chinese medicine preparation for treating insomnia Download PDFInfo
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Abstract
The invention discloses traditional Chinese medicine preparation for treating the insomnia. The traditional Chinese medicine preparation comprises, by weight, 15-20 parts of platycladi seeds, 18-23 parts of corydalis tuber, 9-15 parts of lupulus, 10-16 parts of mint, 8-18 parts of ground peanuts, 10-18 parts of horseshoe fern, 7-15 parts of snow tea, 11-17 parts of herba rubiae yunnanensis, 8-16 parts of gentianopsis barbata, 12-18 parts of rhizoma acori graminei, 9-16 parts of leatherleaf mahonia roots,7-17 parts of daidai flowers, 13-18 parts of lumbricus, 8-16 parts of polygala furcata, 9-21 parts of aizoon stonecrop herbs, 13-19 parts of polygonum multiflorum, 10-15 parts of soletellina diphos and 10-15 parts of poria cocos. The traditional Chinese medicine preparation has the advantages that by means of the preparation, the clinical symptoms of patients are improved obviously, the pain of the patients is relieved, the treatment course is short, the action effect speed is high, and the recrudescence is prevented after the patients are recovered; medicinal materials are easy to obtain, low in cost and free of side effect, and the drug has greater popularization value.
Description
Technical field
The present invention relates to traditional Chinese medicine field, particularly relate to a kind of Chinese medicine preparation of Cure for insomnia.
Background technology
Insomnia is the sleep disordered disease of modal one, is the common clinical manifestation that multiple body, spirit and behavior disease have.Multiple Epidemiological study data shows, the people of western countries about 36.3% has insomnia in various degree; China's insomnia rate is also up to 30-60%.Estimate according to expert, to the nearly insomniac more than 700,000,000 in the year two thousand twenty whole world.The wide range that insomnia occurs, regardless of sex, whether health, old man or youth, all can occur.Therefore, with the quickening pace of modern life, insomnia becomes the important killer threatening human health just day by day.
The main pathogenesis of insomnia is body internal organs imbalance of YIN and YANG, qi-blood disharmony, so that malaise.Primarily of damaged by excess of seven emotions, ponder over too or frightened the causing that dash forward, also have innate deficiency, old and weak, QI and blood, the moon are cloudy unbalance, caused by function is uncomfortable.As " the large puzzled opinion of Ling Shu Miraculous Pivot or Divine Axis " is said: " defend gas and must not enter the moon, often stay in sun, stay in sun then fullness caused by stagnant QI, yang-energy is the tender Sheng of sun completely then, must not enter the moon then cloudy deficiency of vital energy, therefore the unable to close the eyes." primary disease has void to have reality, most course of disease is longer, and be difficult to speed more, easy recurrent exerbation, has a strong impact on work and the quality of life of patient.The pharmacotherapy of current treatment of insomnia patients mainly contains doctor trained in Western medicine and the traditional Chinese medical science two kinds.The key agents of western medical treatment insomnia has benzodiazepine, melatonin class medicine and antidepressant drug etc.Benzodiazepine is acknowledged as at present most popular hypnotic clinically, but this type of medicine of long-term taking easily causes dysmnesia, psychomotor to damage, the untoward reaction such as rebound insomnia after drug addiction and withdrawal.He Min etc. are made up of Semen Ziziphi Spinosae, Caulis Spatholobi, Herba Cirsii, Radix Notoginseng from intending Radix Notoginseng side, have the merit of nourishing blood to tranquillize the mind, removing heat from blood and promoting blood circulation, this policy is fast to modern's rhythm of life, psychentonia, easily cause disturbing in blood deficiency stagnant heat and cause the feature of insomnia and establish.After treating 4 weeks, treatment group is to the length of one's sleep, and the improvement degree of Sleep efficiency integration is obviously better than matched group.
Application publication number CN 103565979 A(application number 201310556205.3) Chinese invention patent document disclose a kind of medicine of Cure for insomnia, be made up of following portions by weight crude drug: Fructus Gardeniae 10-20, Radix Angelicae Sinensis 10-20, Rhizoma Atractylodis Macrocephalae (parched) 10-20, Fructus Jujubae 10-20, Radix Bupleuri 5-10, Herba Menthae 5-10, Radix Paeoniae Alba 20-30, Os Draconis 50-60, Concha Ostreae 50-60.Application publication number CN 104173761 A(application number 201310187100.5) Chinese invention patent document disclose a kind of Chinese medicine of Cure for insomnia, be prepared from by the crude drug of following weight portion: Semen Sesami Nigrum 30-40 gram, RHIZONA GASTRODIAE 15-25 gram, charred Cortex Phellodendri 15-25 gram, Fructus Psoraleae 16-18 gram, Fructus Jujubae preparata core 3-8 gram, Fructus Lycii 25-35 gram, Cornu Cervi Pantotrichum 3-5 gram, application publication number CN 103479961 A(application number 201210195810.8) Chinese invention patent document disclose a kind of Chinese medicine of Cure for insomnia, be prepared from by the crude drug of following weight portion: Poria cum Radix Pini 10 grams, Rhizoma Coptidis 10 grams, Radix Bupleuri 13 grams, Caulis Bambusae In Taenia 13 grams, Radix Curcumae 13 grams, Rhizoma Cyperi 13 grams, Pericarpium Citri Reticulatae 10 grams, Rhizoma Anemones Altaicae 13 grams, the Rhizoma Pinelliae 10 grams, Arisaema Cum Bile 10 grams, Concretio Silicea Bambusae 10 grams, Radix Polygalae 12 grams.
Western medicine insomnia is mainly by suppressing nerve to be treated by force, although can fall asleep, just as people is tied in bed, sleep quality is low, and brain can not get sufficient rest, and long-term taking side effect is large.The traditional Chinese medical science emphasizes the advantages such as organic conception, regulating yin and yang, treating both the principal and secondary aspects of a disease, toxic and side effects are little owing to having, and more and more approved by people, but existing treatment by Chinese herbs is long for the course for the treatment of, slowly effective.
Summary of the invention
For the deficiencies in the prior art, the object of this invention is to provide and a kind ofly prepare simple, safe and effective, to act on Cure for insomnia rapidly Chinese medicine preparation.Chinese medicine preparation determined curative effect of the present invention, cure rate are high, do not recur more.
Technical scheme of the present invention is:
The Chinese medicine preparation of Cure for insomnia, is prepared from by following bulk drugs, is weight portion: Semen Platycladi 15-20; Rhizoma Corydalis 18-23; Flos lupuli (Flos Humuli Lupuli) 9-15; Herba Menthae 10-16; Radix Polygalae Crotalarioidis 8-18; Rhizoma Angiopteridis Fokiensis 10-18; Thamnolia vermicularis (Ach.) Asa-hina 7-15; Herba Rubiae Yunnanensis 11-17; Herba Gentianopsis Paludosae 8-16; Rhizoma Acori Graminei 12-18; Radix Mahoniae 9-16; Citrus aurantium L. var. amara Engl. 7-17; Pheretima 13-18; Kidney fruit Radix Crotalariae szemoensis 8-16; Herba Sedi Aizoon 9-21; Radix Polygoni Multiflori 13-19; Concha Erosariae seu Cypraeae 10-15; Poria 10-15.
In preferred scheme, Semen Platycladi 16-19; Rhizoma Corydalis 19-22; Flos lupuli (Flos Humuli Lupuli) 11-13; Herba Menthae 12-14; Radix Polygalae Crotalarioidis 10-16; Rhizoma Angiopteridis Fokiensis 12-16; Thamnolia vermicularis (Ach.) Asa-hina 10-12; Herba Rubiae Yunnanensis 13-15; Herba Gentianopsis Paludosae 10-14; Rhizoma Acori Graminei 13-17; Radix Mahoniae 11-14; Citrus aurantium L. var. amara Engl. 10-14; Pheretima 15-16; Kidney fruit Radix Crotalariae szemoensis 10-14; Herba Sedi Aizoon 12-18; Radix Polygoni Multiflori 14-18; Concha Erosariae seu Cypraeae 11-14; Poria 11-14.
Be more preferably, Semen Platycladi 17.5; Rhizoma Corydalis 20.5; Flos lupuli (Flos Humuli Lupuli) 12; Herba Menthae 13; Radix Polygalae Crotalarioidis 14; Rhizoma Angiopteridis Fokiensis 14; Thamnolia vermicularis (Ach.) Asa-hina 11; Herba Rubiae Yunnanensis 14; Herba Gentianopsis Paludosae 12; Rhizoma Acori Graminei 15; Radix Mahoniae 12.5; Citrus aurantium L. var. amara Engl. 12; Pheretima 15.5; Kidney fruit Radix Crotalariae szemoensis 12; Herba Sedi Aizoon 15; Radix Polygoni Multiflori 16; Concha Erosariae seu Cypraeae 12.5; Poria 12.5.
The Chinese medicine preparation of Cure for insomnia, be made into pharmaceutically acceptable decoction, preparation method is as follows:
(1) get clean Herba Rubiae Yunnanensis, put in pot and heat with high heat, fry to surface coke black, inner sepia, spray clear water is a little, and go out most Mars, takes out to fry to escape to the greatest extent to aqueous vapor again, takes out, dries, be ground into fine powder for subsequent use; Concha Erosariae seu Cypraeae is cleaned, and dries, smashs into fine powder to pieces, for subsequent use;
(2) get after Rhizoma Acori Graminei sheet moderate heat makes popular, add Sucus Zingberis, fried dry, take out, cool (wherein Rhizoma Acori Graminei: Rhizoma Zingiberis=8:1), smash to pieces, mix with step (1) gained fine powder, sieve for subsequent use;
(3) step (2) gained mixing fine powders and Flos lupuli (Flos Humuli Lupuli), Herba Menthae, Thamnolia vermicularis (Ach.) Asa-hina and Citrus aurantium L. var. amara Engl. are together placed in Chinese medicine extracting tank, add the clear water (preferably adding the clear water of 5 times amount) of 4-6 times amount, slow fire boiling 34-42 minute (preferred slow fire boiling 38 minutes), filters, obtains filtrate;
(4) crude drug except Herba Rubiae Yunnanensis, Concha Erosariae seu Cypraeae, Rhizoma Acori Graminei, Flos lupuli (Flos Humuli Lupuli), Herba Menthae, Thamnolia vermicularis (Ach.) Asa-hina and Citrus aurantium L. var. amara Engl. is placed in Chinese medicinal pot, add clear water and do not have powder 2-4cm, intense fire is heated to boil, turn slow fire boiling twice, first time decocts 56-78 minute, second time decocts 28-46 minute, filters, merges twice decocting liquid;
(5) step (3) gained filtrate joined in above-mentioned decocting liquid, continue to be evaporated to 1/3 of original liquid volume, dry heat sterilization, cooling, encapsulation, to obtain final product.
The preparation method of the Chinese medicine decoction of above-mentioned Cure for insomnia, preferred scheme is, the middle 50-90 mesh sieve excessively of step (2) (preferred 60-80 mesh sieve excessively, mistake 70 mesh sieve be more preferably).
The preparation method of the Chinese medicine decoction of above-mentioned Cure for insomnia, preferred scheme is, in step (4), first time decocts 60-74 minute (preferably first time decocts 67 minutes).
The preparation method of the Chinese medicine decoction of above-mentioned Cure for insomnia, preferred scheme is, in step (4), second time decocts 32-42 minute (preferably second time decocts 37 minutes).
The preparation method of described oral liquid is:
(1) Concha Erosariae seu Cypraeae and Pheretima are cleaned respectively, dry, smash into fine powder to pieces, and 90 mesh sieves are crossed in mixing, for subsequent use;
(2) Rhizoma Acori Graminei, Herba Menthae and Semen Platycladi are placed in Chinese medicament extracting device, add the ethanol (preferably adding the ethanol of 4 times amount) of 3-5 times amount, heating and refluxing extraction twice, reflux, extract, 38-54 minute first time (preferably first time extracts 46 minutes), second time reflux, extract, 28-36 minute (preferably second time reflux, extract, 32 minutes), distillation under pressure, reclaims ethanol, obtains volatile oil for subsequent use;
(3) crude drug except Concha Erosariae seu Cypraeae, Pheretima, Rhizoma Acori Graminei, Herba Menthae and Semen Platycladi is placed in Chinese medicine pan, purify waste water (preferably the adding purifying waste water of 8 times amount) that add 6-10 times amount soaks 1.2 hours, then step (1) gained mixing fine powders is added, moderate heat decocts twice, each respectively decoction 40-50 minute (preferably each each decoction 45 minutes), filter, merge twice decocting liquid;
(4) being continued by above-mentioned decocting liquid to be evaporated to 55 DEG C of relative densities is 1.18-1.20, adds the ethanol that mass concentration is 80%, makes alcohol content reach 40%, stir, leave standstill 16-20 hour (preferably leaving standstill 18 hours), get supernatant, reclaim ethanol, filter, obtain filtrate;
(5) in above-mentioned filtrate, add step (2) gained volatile oil, add high-density syrup, adjustment volume is to 800mL, and shake up, four layers of filtered through gauze, high temperature sterilize, to obtain final product.
The preparation method of described powder is:
(1) getting wheat bran is spread in hot pot, when wheat bran is smoldered, pours Rhizoma Acori Graminei sheet into, fries to yellow degree of being with slow fire, takes out sieve and removes Testa Tritici, cool, smash to pieces for subsequent use; Concha Erosariae seu Cypraeae and Pheretima are cleaned respectively, dry, smash into fine powder to pieces, for subsequent use;
(2) fully be dry, pulverize by surplus stock medicine, the medicated powder after processing with step (1) mixes, and crosses 70-110 mesh sieve (preferred mistake 90 mesh sieve), obtains Chinese powder medicine.
The preparation method of described capsule is:
(1) take each crude drug in proportion, dry, grind into powder, cross 120-160 mesh sieve (preferred mistake 140 mesh sieve), obtain mixed powder;
(2) in above-mentioned medicated powder, add sucrose fine and sodium cellulosate (medicated powder: sucrose fine: sodium cellulosate=6:1.3:1.1), mixing, granulate, incapsulate shell according to 0.4-0.6g/ grain (preferably according to 0.5g/ grain) metering, to obtain final product.
Scientific formula of the present invention, preparation method is simple, effectively easy to use, safe.In addition, excellent results of the present invention also shows:
1,traditional property of medicine and Chinese medicine modern pharmacology organically combine by the present invention, utilize ingredients synergism, jointly play heat-clearing and toxic substances removing, suppressing the hyperactive liver is calmed the nerves, effect of spleen invigorating mind calming, have the effect of thoroughly curing to the insomnia that a variety of causes causes;
2,medicine of the present invention not only obviously improves the clinical symptoms of patient, alleviates misery, and have short treating period, action effect rapidly and more after effect of not recurring;
3,medicine source of the present invention is easy to get, and medical material is with low cost, has no side effect, and has higher promotional value.
The pharmacology of the present invention's main raw material of Chinese medicine used is as follows:
Semen Platycladi: base is former: this product is the dry mature kernal of Cupressaceae plant Cacumen Platycladi.Nature and flavor: sweet are flat.Gui Jing: enter the heart, liver, spleen channel.Function cures mainly: tranquilizing by nourishing the heart, loosening bowel to relieve constipation.Control palpitation with fear, insomnia, seminal emission, night sweat, constipation.Chemical analysis: the fatty oil of seed about 14%, and containing a small amount of volatile oil, Saponin.
Rhizoma Corydalis: base is former: be the tuber of papaveraceae plant corydalis.Nature and flavor: arduous, temperature.Gui Jing: enter liver, stomach warp.Function cures mainly: invigorate blood circulation, and dissipating blood stasis is regulated the flow of vital energy, pain relieving.Control all pains of trusted subordinate's waist knee joint, menoxenia, lump in the abdomen, metrorrhagia, puerperal blood faints, lochiorrhea, traumatic injury.
Flos lupuli (Flos Humuli Lupuli): base is former: be the female inflorescence of moraceae plants Flos lupuli (Flos Humuli Lupuli).Pharmacological action: 1. antibacterial action; 2. sedation; 3. estrogen sample effect.Nature and flavor: bitter in the mouth, slightly cool in nature is nontoxic.Function cures mainly: invigorating the stomach and promoting digestion, and diuresis is calmed the nerves.Control dyspepsia, abdominal distention, edema, cystitis, pulmonary tuberculosis, insomnia.
Herba Menthae: base is former: be herb or the leaf of labiate Herba Menthae or family Herba Menthae.Chemical analysis: fresh leaf is containing volatile oil 0.8 ~ 1%, and scapus leaf is containing 1.3 ~ 2%.In oil, main constituent is menthol, content about 77 ~ 78%, and be secondly menthone, content is 8 ~ 12%, also containing menthyl acetate, camphene, limonene, isomenthone, pinene, piperitenone, resin and a small amount of tannin, rosmarinic acid.Pharmacological action: menthol topical application can control headache, neuralgia, pruritus etc.Be applied to skin, first have cool feeling, have slight thorn to burn later and feel.Nature and flavor: pungent are cool.Gui Jing: enter lung, Liver Channel.Function cures mainly: dispelling wind, and heat radiation, wards off dirty, removing toxic substances.Control affection due to external wind and heat, headache, conjunctival congestion, laryngopharynx swelling and pain, dyspepsia flatulence, aphtha, toothache, skin ulcer scabies, urticaria.
Radix Polygalae Crotalarioidis: base is former: be the root of milk wort Radix Polygalae Crotalarioidis.Nature and flavor: sweet, temperature.Function cures mainly: heart tonifying and tranquilizing, eliminates the phlegm.Control palpitation due to deficiency of blood, insomnia and dreamful sleep, cough expectorant is few.
Rhizoma Angiopteridis Fokiensis: base is former: be the root stock of Angiopteridaceae plant Fujian lotus throne Herba pteridii latiusculi.Nature and flavor: " Luchuan book on Chinese herbal medicine ": " bitter, cold." function cures mainly: dispel the wind, heat clearing away, removing toxic substances.Control cough due to pathogenic wind-heat, mumps, carbuncle sore tumefacting virus, venom, dysfunctional uterine hemorrhage.
Thamnolia vermicularis (Ach.) Asa-hina: base is former: be the thallus of ground Theaceae plant Thamnolia vermicularis (Ach.) Asa-hina.Chemical analysis: Thamnolia vermicularia content acid, squamatic acid, baeomycesic acid, another containing D-R alcohol and mannitol.Nature and flavor: " Traditional Chinese Medicine in Sichuan will ": " light micro-hardship, cool, nontoxic." function cures mainly: heat clearing away is quenched one's thirst, refreshment and tranquilization.Control asthenia hectic fever due to YIN-deficiency, pneumonia is coughed, and epilepsy is manic, neurasthenia, hypertension.
Herba Rubiae Yunnanensis: base is former: for the aerial parts of grass is wished in Maguireothamnus speciosus Yunnan.Nature and flavor: sweet; Flat.Function cures mainly: enrich blood and invigorate blood circulation; Expelling wind and removing dampness.Main anemia; Dizzy insomnia; Rheumatic arthralgia; Chronic gastritis; Traumatic injury; Menoxenia.
Herba Gentianopsis Paludosae: base is former: be the herb of gentianaceae plant China Herba Gentianopsis Paludosae.Nature and flavor: bitter, cold.Function cures mainly: heat-clearing and toxic substances removing, detumescence.Control infectiousness calentura, wound swells and ache, dampness-heat in the liver and gallbladder.
Rhizoma Acori Graminei: another name Rhizoma Anemones Altaicae, water Rhizoma Acori Graminei, powder Chang, mountain Rhizoma Acori Graminei, small stream Chang, stone Scolopendra, wild leek.Base is former: be the rhizome of ranunculaceae plant anemone altaica.Nature and flavor: pungent, flat or tepor.Gui Jing: GUIXIN, liver, spleen channel.Fresh goods strong flavor, pungent loose power more wins than dry product, therefore the good merchantable brand for declaring gas sensible.This product had both been longer than removing dampness by means of aromatics, activating spleen and strengthening stomach, was used for the treatment of cloudy stagnant middle Jiao of turbid damp, vexed swollen, all diseases of anorexia of functional activity of QI being not smooth, breast gastral cavity; And again can fragrant magnificent expectorant turbid, resuscitation inducing and mind tranquilizing, is used for the treatment of the mind that turbid damp hoodwinks clearly caused by key dazed and confused, the disease of white and greasy fur; And arrogate to oneself the unconsciousness controlled expectorant heat and fall caused by stagnant pericardium, the diseases such as tic.
Radix Mahoniae: base is former: be the root of Berberidaceae plant Mahonia bealei (Fort.) Carr. or south China Mahonia fortunei (Lindl.) Fedde.Nature and flavor: 1. " classify herbal ": " cool in nature." 2. " Luchuan book on Chinese herbal medicine ": " bitter, cold, nontoxic." function cures mainly: heat clearing away, pathogenic fire purging, removing heat from blood, removing toxic substances.Control influenza, hematodiarrhoea, diarrhoea, jaundice, spit blood, conjunctivitis, laryngalgia, toothache, furuncle.
Citrus aurantium L. var. amara Engl.: base is former: be the alabastrum of Folium Symplocoris Caudatae profit plant Citrus aurantium L. var. amara Engl..Chemical analysis: alabastrum is containing volatile oil.Main containing limonene, linalool, Geraniol, citronellol, valeric acid etc. in oil.Still containing neohesperidin and naringin.Nature and flavor: " pharmacognosy ": " sweet micro-hardship." function cures mainly: soothing the liver, stomach function regulating, regulates the flow of vital energy.Control painful abdominal mass in the heart vexed, abdominal distention, vomiting, few food.
Pheretima: base is former: this product is the dry body nature and flavor of Ju Yin section animal Pheretima aspergillum, popular Pheretimatschiliensis, power simulation or the blind Pheretimatschiliensis of comb: salty, cold.Gui Jing: return liver, spleen, urinary bladder channel.Effect: heat clearing away is calmed the frightened, and dredging collateral, relievings asthma, diuresis.Cure mainly: for unconsciousness due to high fever, frightened sick tic, arthralgia, numb limbs and tense tendons, hemiplegia.Dyspnea and cough due to lung-heat, oliguria edema; Hypertension.
Kidney fruit Radix Crotalariae szemoensis: base is former: be the whole herb with root of milk wort kidney fruit Radix Crotalariae szemoensis.Nature and flavor: micro-hardship; Flat.Function cures mainly: expelling phlegm for arresting cough; Removing toxic substances; Dissipating blood stasis; Hemostasis.Main cough with copious phlegm; Laryngopharynx swelling and pain; Toothache; Furuncle; Insomnia and dreamful sleep; Traumatic injury; Traumatic hemorrhage.
Herba Sedi Aizoon: base is former: be the herb of crassulaceae plants Herba Sedi Aizoon.Nature and flavor: " Zhejiang conventional medical herbs among the people ": " property is put down, the micro-acid of sweet in the mouth." function cures mainly: hemostasis, blood stasis dispelling.Control haematemesis, epistaxis, have blood in stool, hematuria, metrorrhagia, traumatic injury.
Radix Polygoni Multiflori: base is former: this product is the dried root of polygonum multiflorum thunb.Nature and flavor: bitter, sweet, puckery. temperature.Gui Jing: return liver, the heart, kidney channel.Pharmacological action: 1. effect for reducing blood fat, 2. hypoglycemic activity, 2. antibacterial action.Effect: removing toxic substances, disappears de-, loosening bowel to relieve constipation.Cure mainly: for scrofula carbuncle sore, rubella pruritus, dryness of the intestine constipation; Hyperlipidemia.
Concha Erosariae seu Cypraeae: base is former: be the shell of Cypraeidae animal erosaria caputserpentis, Cypraealynx or silk ribbon attached to an official seal or a medal shellfish etc.Nature and flavor: salty are flat.Gui Jing: " book on Chinese herbal medicine is looked for the truth ": " enter spleen, liver." function cures mainly: heat clearing away, suppressing the hyperactive liver, calms the nerves, improving eyesight.Control pyretic toxicity corneal nebula, children's's macule enters order, frightened cautious sleeplessness.
Poria: base is former: this product is the dry sclerotia of On Polyporaceae Poria.Character: Poria spherical, oval in class, an oblate or irregular agglomerate, not of uniform size.Crust is thin and coarse, and sepia, to pitchy, has obvious shrinkage texture.Nature and flavor: sweet, light are flat.Gui Jing: GUIXIN, lung, spleen, kidney channel.Effect: promoting diuresis to eliminate damp pathogen, spleen invigorating mind calming.Cure mainly: for edema oliguria, phlegm retention vertigo and palpitation, insufficiency of the spleen lack of appetite, have loose bowels in loose stool, irritability, palpitation with fear insomnia.
Detailed description of the invention
Describe technical scheme of the present invention in detail below in conjunction with embodiment and experimental example, but protection domain is not limited thereto.
embodiment 1the Chinese medicine preparation of Cure for insomnia, is prepared from by following bulk drugs, is weight portion (60g/ part): Semen Platycladi 15 parts; Rhizoma Corydalis 18 parts; Flos lupuli (Flos Humuli Lupuli) 9 parts; Herba Menthae 10 parts; Radix Polygalae Crotalarioidis 8 parts; Rhizoma Angiopteridis Fokiensis 10 parts; Thamnolia vermicularis (Ach.) Asa-hina 7 parts; Herba Rubiae Yunnanensis 11 parts; Herba Gentianopsis Paludosae 8 parts; Rhizoma Acori Graminei 12 parts; Radix Mahoniae 9 parts; Citrus aurantium L. var. amara Engl. 7 parts; Pheretima 13 parts; Kidney fruit Radix Crotalariae szemoensis 8 parts; Herba Sedi Aizoon 9 parts; Radix Polygoni Multiflori 13 parts; Concha Erosariae seu Cypraeae 10 parts; 10 parts, Poria.
The preparation method of the Chinese medicine decoction of above-mentioned Cure for insomnia is:
(1) get clean Herba Rubiae Yunnanensis, put in pot and heat with high heat, fry to surface coke black, inner sepia, spray clear water is a little, and go out most Mars, takes out to fry to escape to the greatest extent to aqueous vapor again, takes out, dries, be ground into fine powder for subsequent use; Concha Erosariae seu Cypraeae is cleaned, and dries, smashs into fine powder to pieces, for subsequent use;
(2) get after Rhizoma Acori Graminei sheet moderate heat makes popular, add Sucus Zingberis, fried dry, take out, cool (wherein Rhizoma Acori Graminei: Rhizoma Zingiberis=8:1), smash to pieces, mix with step (1) gained fine powder, mistake 50 mesh sieves, for subsequent use;
(3) step (2) gained mixing fine powders and Flos lupuli (Flos Humuli Lupuli), Herba Menthae, Thamnolia vermicularis (Ach.) Asa-hina and Citrus aurantium L. var. amara Engl. are together placed in Chinese medicine extracting tank, add the clear water of 4 times amount, slow fire boiling 34 minutes, filter, obtain filtrate;
(4) crude drug except Herba Rubiae Yunnanensis, Concha Erosariae seu Cypraeae, Rhizoma Acori Graminei, Flos lupuli (Flos Humuli Lupuli), Herba Menthae, Thamnolia vermicularis (Ach.) Asa-hina and Citrus aurantium L. var. amara Engl. is placed in Chinese medicinal pot, add clear water and do not have powder 2-4cm, intense fire is heated to boil, turn slow fire boiling twice, first time decocts 56 minutes, second time decocts 28 minutes, filters, merges twice decocting liquid;
(5) step (3) gained filtrate joined in above-mentioned decocting liquid, continue to be evaporated to 1/3 of original liquid volume, dry heat sterilization, cooling, encapsulation, to obtain final product.
The instructions of taking of decoction of the present invention is: twice daily, each 100-150mL, warmly takes, 5 days courses for the treatment of.
Model case: Lee XX, man, 25 years old, on June 15th, 2010 was to our hospital.Because a variety of causes fails to find make oneself satisfied work after Mr. Li graduates from university, look for a job period, every day is with a worried frown, and mood is depressed, daytime hunts for a job everywhere, feel exhausted, night should be had a good rest and be regained one's strength of body, but Mr. Li lies on a bed and tosses about, be difficult to fall asleep, sometimes not at all easy sleeping, wake up with a start because of some sounds, insomnia has had a strong impact on the job hunting on Mr.'s Li daytime.When sometimes having a sleepless night serious, Mr. Li takes sleeping pill and carrys out sleeping, has just started energy relief of symptoms, but has slowly defined drug dependence.Present Mr. Li have found suitable work, but insomnia is vaporized for a long time and does not go.Seriously annoying work and the life of Mr. Li.Introduced through colleague afterwards, and came my institute and check treatment.
Take the Chinese medicine decoction of the present embodiment gained Cure for insomnia, instructions of taking: twice daily, each 100-150mL, warmly to take, 5 days courses for the treatment of.After taking a course for the treatment of, patient's insomnia obviously improves, and fall asleep rapidly, the length of one's sleep can reach 4-5 hour, and continue two courses for the treatment of of medication, patient's insomnia thoroughly disappears, more than 7 hours length of one's sleep, and sleep quality is good, and patient fully recovers.Within after drug withdrawal three months, pay a return visit, sleep is good, without recurrence.
embodiment 2the Chinese medicine preparation of Cure for insomnia, is prepared from by following bulk drugs, is weight portion (40g/ part): Semen Platycladi 20 parts; Rhizoma Corydalis 23 parts; Flos lupuli (Flos Humuli Lupuli) 15 parts; Herba Menthae 16 parts; Radix Polygalae Crotalarioidis 18 parts; Rhizoma Angiopteridis Fokiensis 18 parts; Thamnolia vermicularis (Ach.) Asa-hina 15 parts; Herba Rubiae Yunnanensis 17 parts; Herba Gentianopsis Paludosae 16 parts; Rhizoma Acori Graminei 18 parts; Radix Mahoniae 16 parts; Citrus aurantium L. var. amara Engl. 17 parts; Pheretima 18 parts; Kidney fruit Radix Crotalariae szemoensis 16 parts; Herba Sedi Aizoon 21 parts; Radix Polygoni Multiflori 19 parts; Concha Erosariae seu Cypraeae 15 parts; 15 parts, Poria.
The preparation method of the oral liquid of above-mentioned Cure for insomnia is:
(1) Concha Erosariae seu Cypraeae and Pheretima are cleaned respectively, dry, smash into fine powder to pieces, and 90 mesh sieves are crossed in mixing, for subsequent use;
(2) Rhizoma Acori Graminei, Herba Menthae and Semen Platycladi are placed in Chinese medicament extracting device, add the ethanol of 4 times amount, heating and refluxing extraction twice, for the first time reflux, extract, 46 minutes, second time reflux, extract, 32 minutes, and distillation under pressure, reclaims ethanol, obtain volatile oil for subsequent use;
(3) crude drug except Concha Erosariae seu Cypraeae, Pheretima, Rhizoma Acori Graminei, Herba Menthae and Semen Platycladi is placed in Chinese medicine pan, adds the immersion 1.2 hours of purifying waste water of 8 times amount, then add step (1) gained mixing fine powders, moderate heat decocts twice, each each decoction 45 minutes, filters, merges twice decocting liquid;
(4) being continued by above-mentioned decocting liquid to be evaporated to 55 DEG C of relative densities is 1.18-1.20, adds the ethanol that mass concentration is 80%, makes alcohol content reach 40%, stirs, and leaves standstill 18 hours, gets supernatant, reclaims ethanol, filters, obtains filtrate;
(5) in above-mentioned filtrate, add step (2) gained volatile oil, add high-density syrup, adjustment volume is to 800mL, and shake up, four layers of filtered through gauze, high temperature sterilize, to obtain final product.
The instructions of taking of oral liquid of the present invention is: every day three times, each 2-3 props up, 5 days courses for the treatment of.
embodiment 3the Chinese medicine preparation of Cure for insomnia, is prepared from by following bulk drugs, is weight portion (55g/ part): Semen Platycladi 16 parts; Rhizoma Corydalis 19 parts; Flos lupuli (Flos Humuli Lupuli) 11 parts; Herba Menthae 12 parts; Radix Polygalae Crotalarioidis 10 parts; Rhizoma Angiopteridis Fokiensis 12 parts; Thamnolia vermicularis (Ach.) Asa-hina 10 parts; Herba Rubiae Yunnanensis 13 parts; Herba Gentianopsis Paludosae 10 parts; Rhizoma Acori Graminei 13 parts; Radix Mahoniae 11 parts; Citrus aurantium L. var. amara Engl. 10 parts; Pheretima 15 parts; Kidney fruit Radix Crotalariae szemoensis 10 parts; Herba Sedi Aizoon 12 parts; Radix Polygoni Multiflori 14 parts; Concha Erosariae seu Cypraeae 11 parts; 11 parts, Poria.
The preparation method of the Chinese powder medicine of above-mentioned Cure for insomnia is:
(1) getting wheat bran is spread in hot pot, when wheat bran is smoldered, pours Rhizoma Acori Graminei sheet into, fries to yellow degree of being with slow fire, takes out sieve and removes Testa Tritici, cool, smash to pieces for subsequent use; Concha Erosariae seu Cypraeae and Pheretima are cleaned respectively, dry, smash into fine powder to pieces, for subsequent use;
(2) fully be dry, pulverize by surplus stock medicine, the medicated powder after processing with step (1) mixes, and crosses 90 mesh sieves, obtains Chinese powder medicine.
The instructions of taking of powder of the present invention is: every day three times, each 20-25g, and hot water is taken after mixing it with water, 5 days courses for the treatment of.
Model case: grandson XX, female, 43 years old, patient came here on October 9th, 2012 and goes to a doctor.Patient's readme: because operating pressure is comparatively large at ordinary times, spiritual high-pressure, cause nearly 1 year sleep quality to be deteriorated gradually, difficulty falling asleep, can not fall asleep sometimes whole night, a barrage of daydream after sometimes falling asleep.Morning plays look dispirited, and the mental status is not good, very painful.Exacerbation of symptoms before one month, once in local hospital treatment, therapeutic effect was undesirable, bad during fashion.Introduce my institute through friend afterwards and check treatment.Check: patient's body of the tongue is light red, thin fur, stringy pulse.Check through each system laboratory, find no other organic diseases nypnapagogic.Be diagnosed as insomnia.
Take the Chinese powder medicine of the present embodiment gained Cure for insomnia, instructions of taking is: every day three times, each 20-25g, and hot water is taken after mixing it with water, 5 days courses for the treatment of.After treating a course for the treatment of, patient feels physical relaxation, and more comparatively, the length of one's sleep can reach 4-5 hour to the mental status, without having a dream, after waking up, hale and hearty, health is salubrious, two courses for the treatment of of continual cure, patient's insomnia thoroughly disappears, more than 7 hours length of one's sleep, and sleep quality is good, and patient fully recovers.Within after drug withdrawal three months, pay a return visit, sleep is good, without recurrence.
embodiment 4the Chinese medicine preparation of Cure for insomnia, is prepared from by following bulk drugs, is weight portion (45g/ part): Semen Platycladi 19 parts; Rhizoma Corydalis 22 parts; Flos lupuli (Flos Humuli Lupuli) 13 parts; Herba Menthae 14 parts; Radix Polygalae Crotalarioidis 16 parts; Rhizoma Angiopteridis Fokiensis 16 parts; Thamnolia vermicularis (Ach.) Asa-hina 12 parts; Herba Rubiae Yunnanensis 15 parts; Herba Gentianopsis Paludosae 14 parts; Rhizoma Acori Graminei 17 parts; Radix Mahoniae 14 parts; Citrus aurantium L. var. amara Engl. 14 parts; Pheretima 16 parts; Kidney fruit Radix Crotalariae szemoensis 14 parts; Herba Sedi Aizoon 18 parts; Radix Polygoni Multiflori 18 parts; Concha Erosariae seu Cypraeae 14 parts; 14 parts, Poria.
The preparation method of the Chinese medicine capsules of above-mentioned Cure for insomnia is:
(1) take each crude drug in proportion, dry, grind into powder, cross 140 mesh sieves, obtain mixed powder;
(2) in above-mentioned medicated powder, add sucrose fine and sodium cellulosate (medicated powder: sucrose fine: sodium cellulosate=6:1.3:1.1), mixing, granulate, incapsulate shell according to the metering of 0.5g/ grain, to obtain final product.
The instructions of taking of capsule of the present invention is: every day three times, each 3-5 grain, and warm water takes, 5 days courses for the treatment of.
embodiment 5the Chinese medicine preparation of Cure for insomnia, is prepared from by following bulk drugs, is weight portion (50g/ part): Semen Platycladi 17.5 parts; Rhizoma Corydalis 20.5 parts; Flos lupuli (Flos Humuli Lupuli) 12 parts; Herba Menthae 13 parts; Radix Polygalae Crotalarioidis 14 parts; Rhizoma Angiopteridis Fokiensis 14 parts; Thamnolia vermicularis (Ach.) Asa-hina 11 parts; Herba Rubiae Yunnanensis 14 parts; Herba Gentianopsis Paludosae 12 parts; Rhizoma Acori Graminei 15 parts; Radix Mahoniae 12.5 parts; Citrus aurantium L. var. amara Engl. 12 parts; Pheretima 15.5 parts; Kidney fruit Radix Crotalariae szemoensis 12 parts; Herba Sedi Aizoon 15 parts; Radix Polygoni Multiflori 16 parts; Concha Erosariae seu Cypraeae 12.5 parts; 12.5 parts, Poria.
The preparation method of the Chinese medicine decoction of above-mentioned Cure for insomnia is:
(1) get clean Herba Rubiae Yunnanensis, put in pot and heat with high heat, fry to surface coke black, inner sepia, spray clear water is a little, and go out most Mars, takes out to fry to escape to the greatest extent to aqueous vapor again, takes out, dries, be ground into fine powder for subsequent use; Concha Erosariae seu Cypraeae is cleaned, and dries, smashs into fine powder to pieces, for subsequent use;
(2) get after Rhizoma Acori Graminei sheet moderate heat makes popular, add Sucus Zingberis, fried dry, take out, cool (wherein Rhizoma Acori Graminei: Rhizoma Zingiberis=8:1), smash to pieces, mix with step (1) gained fine powder, mistake 70 mesh sieves, for subsequent use;
(3) step (2) gained mixing fine powders and Flos lupuli (Flos Humuli Lupuli), Herba Menthae, Thamnolia vermicularis (Ach.) Asa-hina and Citrus aurantium L. var. amara Engl. are together placed in Chinese medicine extracting tank, add the clear water of 5 times amount, slow fire boiling 38 minutes, filter, obtain filtrate;
(4) crude drug except Herba Rubiae Yunnanensis, Concha Erosariae seu Cypraeae, Rhizoma Acori Graminei, Flos lupuli (Flos Humuli Lupuli), Herba Menthae, Thamnolia vermicularis (Ach.) Asa-hina and Citrus aurantium L. var. amara Engl. is placed in Chinese medicinal pot, add clear water and do not have powder 2-4cm, intense fire is heated to boil, turn slow fire boiling twice, first time decocts 67 minutes, second time decocts 37 minutes, filters, merges twice decocting liquid;
(5) step (3) gained filtrate joined in above-mentioned decocting liquid, continue to be evaporated to 1/3 of original liquid volume, dry heat sterilization, cooling, encapsulation, to obtain final product.
The instructions of taking of gained decoction of the present invention is: twice daily, each 100-150mL, warmly takes, 5 days courses for the treatment of.
test example 1the clinical practice of the Chinese medicine preparation (embodiment 5) of gained Cure for insomnia of the present invention:
1 data and method
1.1 physical data
In October, 2010, in December ,-2013, screened insomniac's totally 349 examples of accepting for medical treatment at 5 hospital's Neurology Departments, wherein male patient 170 example, female patient 179 example, max age 80 years old, minimal ages 18 years old, 45.5 years old mean age.The course of disease was at 3 months-5 years.
1.2 diagnosis basis
Subjective criterion (clinical criteria): (1) fall asleep or maintain dyskoimesis or after sleeping energy still can not get recover, main suit's sleep disorder was more than 3 weeks.(2) the symptom system such as daytime is tired, dizzy is caused by sleep disorder disturbs.(3) only there is amount of sleep to reduce and do not think insomnia without daytime discomfort (Short sleeper).
Objective criterion: (1) Sleep latency extends, goes to bed in latter 30 minutes and can not fall asleep.(2) reduce the actual length of one's sleep, whole length of one's sleep was less than 6.5 hours every night.(3) the awakening time increases, and wakes up midnight every night can not to fall asleep more than 30 minutes.
1.3 Therapeutic Method
All patients are divided into experimental group and matched group at random, and two groups of patients, in age, the state of an illness, the course of disease etc., through statistical procedures no significant difference (P > 0.05), have comparability.Wherein experimental group uses the Chinese medicine preparation of gained Cure for insomnia of the present invention, using method: twice daily, each 100-150mL, warmly takes, 5 days courses for the treatment of.Observe three courses for the treatment of of treatment altogether.Matched group uses other drug (as medicines such as JIEYUANSHEN KELI, ANSHEN BUXIN WAN and mind-easing tonic bolus with arborvitate seed).
1.4 curative effect determinate standard
Judge with reference to " new Chinese medicine guideline of clinical investigations " relevant criterion.
Cure: after treatment, sleep is normal, simultaneous phenomenon disappears, and follows up a case by regular visits to one month without recurrence; Effective: after treatment, the length of one's sleep extends, and simultaneous phenomenon improves; Effective: patient mental's shape is wished and simultaneous phenomenon is improved; Invalid: symptom is without change.(total effective rate=cure rate+obvious effective rate+effective percentage)
1.5 therapeutic outcome
Result is as shown in table 1.
Table 1: the therapeutic outcome of experimental group and matched group
Therapeutic effect: experimental group total effective rate is 98.6%, and matched group total effective rate is 77.5%.It can thus be appreciated that experimental group successful is better than matched group.
The present invention by Semen Platycladi, Rhizoma Corydalis, Flos lupuli (Flos Humuli Lupuli), Herba Menthae, Radix Polygalae Crotalarioidis, Rhizoma Angiopteridis Fokiensis, Thamnolia vermicularis (Ach.) Asa-hina, Herba Rubiae Yunnanensis, Herba Gentianopsis Paludosae, Rhizoma Acori Graminei, Radix Mahoniae, Citrus aurantium L. var. amara Engl., Pheretima, kidney fruit Radix Crotalariae szemoensis, Herba Sedi Aizoon, Radix Polygoni Multiflori, Concha Erosariae seu Cypraeae and Poria totally 18 taste primary raw material medicines be prepared from.Fang Zhong, Semen Platycladi tranquilizing by nourishing the heart, loosening bowel to relieve constipation; Flos lupuli (Flos Humuli Lupuli) invigorating the stomach and promoting digestion, diuresis is calmed the nerves; Radix Polygalae Crotalarioidis heart tonifying and tranquilizing, eliminates the phlegm; Rhizoma Angiopteridis Fokiensis dispels the wind, heat clearing away, removing toxic substances; Thamnolia vermicularis (Ach.) Asa-hina heat clearing away is quenched one's thirst, refreshment and tranquilization; Herba Rubiae Yunnanensis cures mainly dizzy insomnia; Rhizoma Acori Graminei resuscitation inducing and mind tranquilizing; Radix Mahoniae heat clearing away, pathogenic fire purging; Citrus aurantium L. var. amara Engl. is soothing the liver, stomach function regulating, regulates the flow of vital energy; Pheretima heat clearing away is calmed the frightened.All medicine compatibilities, bring out the best in each other, and play the merit of spleen invigorating mind calming, heat clearing and tranquillizing altogether.After treating three courses for the treatment of, experimental group total effective rate is 98.6%, evident in efficacy.
It should be pointed out that detailed description of the invention is the more representational example of the present invention, obvious technical scheme of the present invention is not limited to above-described embodiment, can also have a lot of distortion.Those of ordinary skill in the art, with the present invention clear and definite disclosed or according to undoubted the obtaining of the written description of file, the claimed scope of this patent all should be thought.
Claims (10)
1. the Chinese medicine preparation of Cure for insomnia, is characterized in that, is prepared from by following bulk drugs, is weight portion: Semen Platycladi 15-20; Rhizoma Corydalis 18-23; Flos lupuli (Flos Humuli Lupuli) 9-15; Herba Menthae 10-16; Radix Polygalae Crotalarioidis 8-18; Rhizoma Angiopteridis Fokiensis 10-18; Thamnolia vermicularis (Ach.) Asa-hina 7-15; Herba Rubiae Yunnanensis 11-17; Herba Gentianopsis Paludosae 8-16; Rhizoma Acori Graminei 12-18; Radix Mahoniae 9-16; Citrus aurantium L. var. amara Engl. 7-17; Pheretima 13-18; Kidney fruit Radix Crotalariae szemoensis 8-16; Herba Sedi Aizoon 9-21; Radix Polygoni Multiflori 13-19; Concha Erosariae seu Cypraeae 10-15; Poria 10-15.
2. the Chinese medicine preparation of Cure for insomnia as claimed in claim 1, is characterized in that, be prepared from by following bulk drugs, be weight portion: Semen Platycladi 16-19; Rhizoma Corydalis 19-22; Flos lupuli (Flos Humuli Lupuli) 11-13; Herba Menthae 12-14; Radix Polygalae Crotalarioidis 10-16; Rhizoma Angiopteridis Fokiensis 12-16; Thamnolia vermicularis (Ach.) Asa-hina 10-12; Herba Rubiae Yunnanensis 13-15; Herba Gentianopsis Paludosae 10-14; Rhizoma Acori Graminei 13-17; Radix Mahoniae 11-14; Citrus aurantium L. var. amara Engl. 10-14; Pheretima 15-16; Kidney fruit Radix Crotalariae szemoensis 10-14; Herba Sedi Aizoon 12-18; Radix Polygoni Multiflori 14-18; Concha Erosariae seu Cypraeae 11-14; Poria 11-14.
3. the Chinese medicine preparation of Cure for insomnia as claimed in claim 1, is characterized in that, be prepared from by following bulk drugs, be weight portion: Semen Platycladi 17.5; Rhizoma Corydalis 20.5; Flos lupuli (Flos Humuli Lupuli) 12; Herba Menthae 13; Radix Polygalae Crotalarioidis 14; Rhizoma Angiopteridis Fokiensis 14; Thamnolia vermicularis (Ach.) Asa-hina 11; Herba Rubiae Yunnanensis 14; Herba Gentianopsis Paludosae 12; Rhizoma Acori Graminei 15; Radix Mahoniae 12.5; Citrus aurantium L. var. amara Engl. 12; Pheretima 15.5; Kidney fruit Radix Crotalariae szemoensis 12; Herba Sedi Aizoon 15; Radix Polygoni Multiflori 16; Concha Erosariae seu Cypraeae 12.5; Poria 12.5.
4. the Chinese medicine preparation of the Cure for insomnia as described in as arbitrary in claim 1-3, it is characterized in that, be made into pharmaceutically acceptable decoction, preparation method is as follows:
(1) get clean Herba Rubiae Yunnanensis, put in pot and heat with high heat, fry to surface coke black, inner sepia, spray clear water is a little, and go out most Mars, takes out to fry to escape to the greatest extent to aqueous vapor again, takes out, dries, be ground into fine powder for subsequent use; Concha Erosariae seu Cypraeae is cleaned, and dries, smashs into fine powder to pieces, for subsequent use;
(2) get after Rhizoma Acori Graminei sheet moderate heat makes popular, add Sucus Zingberis, fried dry, take out, cool (wherein Rhizoma Acori Graminei: Rhizoma Zingiberis=8:1), smash to pieces, mix with step (1) gained fine powder, sieve for subsequent use;
(3) step (2) gained mixing fine powders and Flos lupuli (Flos Humuli Lupuli), Herba Menthae, Thamnolia vermicularis (Ach.) Asa-hina and Citrus aurantium L. var. amara Engl. are together placed in Chinese medicine extracting tank, add the clear water (preferably adding the clear water of 5 times amount) of 4-6 times amount, slow fire boiling 34-42 minute (preferred slow fire boiling 38 minutes), filters, obtains filtrate;
(4) crude drug except Herba Rubiae Yunnanensis, Concha Erosariae seu Cypraeae, Rhizoma Acori Graminei, Flos lupuli (Flos Humuli Lupuli), Herba Menthae, Thamnolia vermicularis (Ach.) Asa-hina and Citrus aurantium L. var. amara Engl. is placed in Chinese medicinal pot, add clear water and do not have powder 2-4cm, intense fire is heated to boil, turn slow fire boiling twice, first time decocts 56-78 minute, second time decocts 28-46 minute, filters, merges twice decocting liquid;
(5) step (3) gained filtrate joined in above-mentioned decocting liquid, continue to be evaporated to 1/3 of original liquid volume, dry heat sterilization, cooling, encapsulation, to obtain final product.
5. the preparation method of the Chinese medicine decoction of Cure for insomnia according to claim 4, is characterized in that, the middle 50-90 mesh sieve excessively of step (2) (preferred 60-80 mesh sieve excessively, mistake 70 mesh sieve be more preferably).
6. the preparation method of the Chinese medicine decoction of Cure for insomnia according to claim 4, is characterized in that, in step (4), first time decocts 60-74 minute (preferably first time decocts 67 minutes).
7. the preparation method of the Chinese medicine decoction of Cure for insomnia according to claim 4, is characterized in that, in step (4), second time decocts 32-42 minute (preferably second time decocts 37 minutes).
8. the Chinese medicine preparation of the Cure for insomnia as described in as arbitrary in claim 1-3, it is characterized in that, be made into pharmaceutically acceptable oral liquid, preparation method is as follows:
(1) Concha Erosariae seu Cypraeae and Pheretima are cleaned respectively, dry, smash into fine powder to pieces, and 90 mesh sieves are crossed in mixing, for subsequent use;
(2) Rhizoma Acori Graminei, Herba Menthae and Semen Platycladi are placed in Chinese medicament extracting device, add the ethanol (preferably adding the ethanol of 4 times amount) of 3-5 times amount, heating and refluxing extraction twice, reflux, extract, 38-54 minute first time (preferably first time extracts 46 minutes), second time reflux, extract, 28-36 minute (preferably second time reflux, extract, 32 minutes), distillation under pressure, reclaims ethanol, obtains volatile oil for subsequent use;
(3) crude drug except Concha Erosariae seu Cypraeae, Pheretima, Rhizoma Acori Graminei, Herba Menthae and Semen Platycladi is placed in Chinese medicine pan, purify waste water (preferably the adding purifying waste water of 8 times amount) that add 6-10 times amount soaks 1.2 hours, then step (1) gained mixing fine powders is added, moderate heat decocts twice, each respectively decoction 40-50 minute (preferably each each decoction 45 minutes), filter, merge twice decocting liquid;
(4) being continued by above-mentioned decocting liquid to be evaporated to 55 DEG C of relative densities is 1.18-1.20, adds the ethanol that mass concentration is 80%, makes alcohol content reach 40%, stir, leave standstill 16-20 hour (preferably leaving standstill 18 hours), get supernatant, reclaim ethanol, filter, obtain filtrate;
(5) in above-mentioned filtrate, add step (2) gained volatile oil, add high-density syrup, adjustment volume is to 800mL, and shake up, four layers of filtered through gauze, high temperature sterilize, to obtain final product.
9. the Chinese medicine preparation of the Cure for insomnia as described in as arbitrary in claim 1-3, it is characterized in that, be made into pharmaceutically acceptable powder, preparation method is as follows:
(1) getting wheat bran is spread in hot pot, when wheat bran is smoldered, pours Rhizoma Acori Graminei sheet into, fries to yellow degree of being with slow fire, takes out sieve and removes Testa Tritici, cool, smash to pieces for subsequent use; Concha Erosariae seu Cypraeae and Pheretima are cleaned respectively, dry, smash into fine powder to pieces, for subsequent use;
(2) fully be dry, pulverize by surplus stock medicine, the medicated powder after processing with step (1) mixes, and crosses 70-110 mesh sieve (preferred mistake 90 mesh sieve), obtains Chinese powder medicine.
10. the Chinese medicine preparation of the Cure for insomnia as described in as arbitrary in claim 1-3, it is characterized in that, be made into pharmaceutically acceptable capsule, preparation method is as follows:
(1) take each crude drug in proportion, dry, grind into powder, cross 120-160 mesh sieve (preferred mistake 140 mesh sieve), obtain mixed powder;
(2) in above-mentioned medicated powder, add sucrose fine and sodium cellulosate (medicated powder: sucrose fine: sodium cellulosate=6:1.3:1.1), mixing, granulate, incapsulate shell according to 0.4-0.6g/ grain (preferably according to 0.5g/ grain) metering, to obtain final product.
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Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1153046A (en) * | 1995-12-26 | 1997-07-02 | 沈阳科进工程有限公司 | Brain protection liquid |
| CN1650895A (en) * | 2004-02-02 | 2005-08-10 | 姜伟 | Method of extracting medicamout having memory strengthening function from natural plant compound preparation |
| CN102283999A (en) * | 2011-08-08 | 2011-12-21 | 许建成 | Traditional Chinese medicine preparation for treating insomnia |
-
2015
- 2015-04-02 CN CN201510153469.3A patent/CN104688973A/en not_active Withdrawn
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1153046A (en) * | 1995-12-26 | 1997-07-02 | 沈阳科进工程有限公司 | Brain protection liquid |
| CN1650895A (en) * | 2004-02-02 | 2005-08-10 | 姜伟 | Method of extracting medicamout having memory strengthening function from natural plant compound preparation |
| CN102283999A (en) * | 2011-08-08 | 2011-12-21 | 许建成 | Traditional Chinese medicine preparation for treating insomnia |
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