CN104672235A - 一类含双酰胺基和烷氧苯基结构的FXa抑制剂及其用途 - Google Patents
一类含双酰胺基和烷氧苯基结构的FXa抑制剂及其用途 Download PDFInfo
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- CN104672235A CN104672235A CN201510083414.XA CN201510083414A CN104672235A CN 104672235 A CN104672235 A CN 104672235A CN 201510083414 A CN201510083414 A CN 201510083414A CN 104672235 A CN104672235 A CN 104672235A
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- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
Description
化合物 | IC50(nM) |
Edoxaban | 4.0 |
参比化合物D-1 | 7.8 |
化合物I-1 | 3.7 |
化合物I-2 | 5.2 |
Claims (4)
Priority Applications (1)
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CN201510083414.XA CN104672235B (zh) | 2015-02-14 | 2015-02-14 | 一类含双酰胺基和烷氧苯基结构的FXa抑制剂及其用途 |
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CN201510083414.XA CN104672235B (zh) | 2015-02-14 | 2015-02-14 | 一类含双酰胺基和烷氧苯基结构的FXa抑制剂及其用途 |
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CN104672235A true CN104672235A (zh) | 2015-06-03 |
CN104672235B CN104672235B (zh) | 2016-02-17 |
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Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1420882A (zh) * | 1999-07-28 | 2003-05-28 | 阿温蒂斯药物公司 | 取代的氧代氮杂杂环基化合物 |
CN101223167A (zh) * | 2005-07-15 | 2008-07-16 | 弗·哈夫曼-拉罗切有限公司 | 新的杂芳基稠合的环状胺 |
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2015
- 2015-02-14 CN CN201510083414.XA patent/CN104672235B/zh active Active
Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1420882A (zh) * | 1999-07-28 | 2003-05-28 | 阿温蒂斯药物公司 | 取代的氧代氮杂杂环基化合物 |
CN101223167A (zh) * | 2005-07-15 | 2008-07-16 | 弗·哈夫曼-拉罗切有限公司 | 新的杂芳基稠合的环状胺 |
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CN104672235B (zh) | 2016-02-17 |
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GR01 | Patent grant | ||
PE01 | Entry into force of the registration of the contract for pledge of patent right | ||
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Denomination of invention: FXa inhibitors containing diamido and alkoxyphenyl structures and application thereof Effective date of registration: 20170816 Granted publication date: 20160217 Pledgee: Guangdong Nanhai Rural Commercial Bank branch branch of Limited by Share Ltd Pledgor: FOSHAN SAIWEISI PHARMACEUTICAL TECHNOLOGY CO., LTD. Registration number: 2017990000756 |
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Date of cancellation: 20190604 Granted publication date: 20160217 Pledgee: Guangdong Nanhai Rural Commercial Bank branch branch of Limited by Share Ltd Pledgor: FOSHAN SAIWEISI PHARMACEUTICAL TECHNOLOGY CO., LTD. Registration number: 2017990000756 |
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Effective date of registration: 20191113 Address after: 225321 Industrial Park, Dasi Town, Gaogang District, Taizhou City, Jiangsu Province Patentee after: Luan Yong Address before: Chancheng district has 528000 Taiwan public in Guangdong province Foshan City No. 32 first floor 1636, shop No. 1637 Patentee before: FOSHAN SAIWEISI PHARMACEUTICAL TECHNOLOGY CO., LTD. |
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Address after: 21 Gangcheng Road, Gangcheng street, Gaogang District, Taizhou City, Jiangsu Province, 225300 Patentee after: Luan Yong Address before: 225321 Industrial Park, Dasi Town, Gaogang District, Taizhou City, Jiangsu Province Patentee before: Luan Yong |
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