CN104667022A - Ointment for traumatic injury and preparation method of ointment - Google Patents
Ointment for traumatic injury and preparation method of ointment Download PDFInfo
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Abstract
The invention discloses an ointment for a traumatic injury. The ointment is mainly prepared from the following raw materials in parts by weight: 5-10 parts of earthworm, 3-6 parts of panax notoginseng, 2-4 parts of trogopterus dung, 6-9 parts of cimicifugae foetidae charcoal, 5-9 parts of rhizoma corydalis, 3-6 parts of fistular onion stalk, 2-5 parts of rumex japonicas, 4-8 parts of szechuan melandium root, 6-9 parts of aconitum kusnezoffii, 6-9 parts of kadsura root bark, 4-8 parts of geranium wilfordii and a proper amount of millet. The ointment has the effects of activating blood to remove stasis, eliminating stagnant blood, relieving pain, stopping bleeding and removing swelling, and is suitable for treatment of kinds of traumatic injuries. The product prepared by the ointment is significant in curative effect, fast in acting, free of toxic or side effect, safe and reliable, and is capable of treating both symptoms and root causes, and sequela is prevented.
Description
Technical field
The present invention relates to traditional Chinese medicine field, particularly relate to a kind of ointment for treating bone fracture and injury and preparation method.
Background technology
Traumatic injury comprises weapons, tumbling down, hits, sprain and contusion, stab, abrade, athletic injury, sprain, there are pain, swelling, hemorrhage or fracture, dislocation etc. in injury more.At this mainly based on soft tissue injury.Stand direct wound, or the tissue of wound and long-term strain indirectly, there is microcirculation disturbance.Due to capillary wall sepage or hemorrhage, cause the formation of the hypostasis thing of tissue, and there occurs aseptic inflammation, cause swollen tissue pain.If the absorption of hypostasis thing can not be impelled, adhesion will be produced.Can there is ischemic contracture in the adhesion of muscle, tendon, the adhesion outside intraarticular just causes the tetanic of joint.Cold compress should be adopted immediately, to make affected part vasoconstriction and to reduce hemorrhage, edema and pain after damage.Plaster is a kind of dosage form that treatment traumatic injury is commonly used, because it has higher denseness, and active constituent content is high, speed of separating out is slow, action period is long, is for the good a kind of dosage form of topical therapeutic.Effective ingredient in externally applied plaster can penetrate skin generation and invigorate blood circulation, pain relieving, and change and become silted up, dredge the meridian passage, the effects such as deep, expelling wind and cold of having one's ideas straightened out, finally reach the effect for the treatment of.Publication No. CN 102908414 A(application number 201210459648.6) Chinese patent literature disclose a kind of externally applied ointment for the treatment of fracture, traumatic injury, be made up of Semen Momordicae, Herba Ephedrae, Radix Notoginseng, the Cortex Eucommiae, Radix Polygoni Multiflori, the Rhizoma Atractylodis Macrocephalae, Flos Carthami, the Radix Aucklandiae, Radix Angelicae Pubescentis, Fructus Schisandrae Chinensis, Huang Shi, the Radix Paeoniae Alba, Radix Glycyrrhizae, Moschus, Camphora, Plumbum preparatium, Oleum sesami.Publication No. CN 102772743 A(application number 201210290244.9) Chinese patent literature disclose a kind of BAICAO ointment for treating bone fracture and injury and preparation method thereof, comprise Rhizoma Polygoni Cuspidati, Herba sambuci chinensis, Radix Aconiti Kusnezoffii, the Rhizoma Pinelliae, Radix Rubiae, the Cortex Eucommiae, Radix Dipsaci, Radix Achyranthis Bidentatae, Rhizoma Drynariae, Stigma Croci, Lithargyrum, Radix Rehmanniae, Semen Momordicae, Radix Saposhnikoviae, Radix Et Rhizoma Rhei, Fructus Aurantii Immaturus, Semen Persicae, Olibanum, Scolopendra, Agkistrodon, Cornu Cervi Pantotrichum, Eupolyphaga Seu Steleophaga, Squama Manis, Agkistrodon, Zaocys, Periostracum Serpentis, Scorpio, joy clam, Bombyx Batryticatus etc.Publication No. CN 103860946 A(application number 201410131771.4) Chinese patent literature disclose a kind of external-applied ointment and preparation method for the treatment of traumatic injury, raw material composition have Rhizoma Humatae Tyermanni, Radix sacchari arundinacei, Herba Chlorophyti, Herba sedi kamtschatici, Herba Corydalis tomentellae, Edgeworthia chrysantha Lindl., Herba Biondiae henryi, Vaccinium bracteatum Thunb., Cauliset Folium Piperis Hancei, Flos Begoniae Evansianae, Shi Rong, Radix indigoferae incarnatae, Semen Cuscutae, Radix Merremiae hungaiensis, Dryopteris lacera (Thunb.) O. Ktze. and Menemerus confusus.
About the traditional Chinese medical science ointment of traumatic injury has many kinds, have external, interior, also have inside and outside dual-purpose, fully demonstrate the advantage of the traditional Chinese medical science in treatment traumatic injury, but the inadequate science of the selection of some of them ointment, make drug effect very unobvious, treatment cycle is long, also need other drug auxiliary treatment, and the effect of thoroughly radical cure can not be reached, even can leave sequela to patient, therefore, need the Chinese medicinal ointment exploring better efficacy, make up the defect of prior art.
Summary of the invention
For the defect of prior art, the object of this invention is to provide a kind of ointment for treating bone fracture and injury and the preparation method of preparing simple, good effect, instant effect.
Technical scheme of the present invention is:
A kind of ointment for treating bone fracture and injury, is prepared from primarily of following bulk drugs, is mass parts: Pheretima 5-10, Radix Notoginseng 3-6, Oletum Trogopterori 2-4, Rhizoma Cimicifugae charcoal 6-9, Rhizoma Corydalis 5-9, Bulbus Allii Fistulosi 3-6, Radix Rumicis Japonici 2-5, Radix Melandrii szechuanensis 4-8, Radix Aconiti Kusnezoffii 6-9, Cortex cercis chinensis 6-9, Herba Erodii 4-8, Semen setariae is appropriate.
In preferred scheme, Pheretima 6-9, Radix Notoginseng 4-5, Oletum Trogopterori 2.5-3.5, Rhizoma Cimicifugae charcoal 7-8, Rhizoma Corydalis 6-8, Bulbus Allii Fistulosi 4-5, Radix Rumicis Japonici 3-4, Radix Melandrii szechuanensis 5-7, Radix Aconiti Kusnezoffii 7-8, Cortex cercis chinensis 7-8, Herba Erodii 5-7, Semen setariae is appropriate.
Be more preferably, Pheretima 7.5, Radix Notoginseng 4.5, Oletum Trogopterori 3, Rhizoma Cimicifugae charcoal 7.5, Rhizoma Corydalis 7, Bulbus Allii Fistulosi 4.5, Radix Rumicis Japonici 3.5, Radix Melandrii szechuanensis 6, Radix Aconiti Kusnezoffii 7.5, Cortex cercis chinensis 7.5, Herba Erodii 6, Semen setariae is appropriate.
The preparation method of described a kind of ointment for treating bone fracture and injury is:
(1) get Radix Aconiti Kusnezoffii to clean, after flooding a night with Sucus Zingberis, take out with Semen sojae atricolor with boiling, boil to Radix Aconiti Kusnezoffii well-done, take out, cool completely, section, dries;
(2) after frying pan big fire being heated, be sprinkled into Testa Tritici skin, after smoldering, add clean Cortex cercis chinensis, stir-fry fast 5 minutes, then spray mature vinegar, mix thoroughly, Guan Huo, slightly vexed, take out, sieve removes wheat bran, dries in the air cool;
(3) Oletum Trogopterori is picked clean impurity, rinse well, to dry in the air to surface without after the globule, put into mortar, smash to pieces, then add Chinese liquor and grind together, grind and grind stopping completely to Oletum Trogopterori, obtain mixed liquor;
(4) by Radix Notoginseng, Rhizoma Corydalis, Bulbus Allii Fistulosi, Radix Rumicis Japonici, Radix Melandrii szechuanensis and Herba Erodii removing impurity, clean, reinstate the warm water soaking of 40 DEG C after 20 minutes with step (1) (2) made crude drug one, pour in non iron container, big fire is heated to boiling, then add step (3) made mixed liquor, again turn little fire after boiling and decoct 20-40 minute, filter, collect filtrate, by the Pheretima of pulverizing and Rhizoma Cimicifugae charcoal, join in filtrate and stir, heating is condensed into clear paste;
(5) get Semen setariae and add decocting in water to medium well, pull out, be ground into Semen setariae end, the Semen setariae end that qinghuo reagent quality is 0.3 times mixes with step (4) made clear paste, obtains ointment for treating bone fracture and injury.
The preparation method of described a kind of ointment for treating bone fracture and injury, the amount of step (1) Semen sojae atricolor is 0.4 times of Radix Aconiti Kusnezoffii quality.
The preparation method of described a kind of ointment for treating bone fracture and injury, the amount of step (2) mature vinegar is 0.3 times of Cortex cercis chinensis quality.
The preparation method of described a kind of ointment for treating bone fracture and injury, the amount of step (3) Chinese liquor is the 4-6 of Oletum Trogopterori quality doubly (preferred, the amount of Chinese liquor is 5 times of Oletum Trogopterori quality).
The preparation method of described a kind of ointment for treating bone fracture and injury, doubly (preferred, the 7-8 that the amount of warm water is boiled crude drug quality is doubly for the 6-9 that the amount of step (4) warm water is boiled crude drug quality; Be more preferably, 7.5 times that the amount of warm water is boiled crude drug quality).
The preparation method of described a kind of ointment for treating bone fracture and injury, step (4) turns little fire and decocts 25-35 minute (preferred, again to turn little fire after boiling and decoct 30 minutes) after again seething with excitement.
The preparation method of described a kind of ointment for treating bone fracture and injury, the relative density of step (4) clear paste is 1.14-1.26(60 DEG C) (preferred, the relative density of clear paste is 1.16-1.24; Be more preferably, the relative density of clear paste is 1.20).
A kind of ointment for treating bone fracture and injury scientific formula provided by the invention, preparation is simple, easy to use.In addition, excellent results of the present invention also shows:
1, the present invention has the effect of blood circulation promoting and blood stasis dispelling, eliminating stasis to stop pain, hemostasia and detumescence, is applicable to the treatment of various traumatic injury;
2, products made thereby of the present invention is evident in efficacy, instant effect, and without obvious toxic-side effects, curative effect is safe and reliable;
3, the present invention can treating both the principal and secondary aspects of a disease, prevents the appearance of sequela.
Detailed description of the invention
Describe technical scheme of the present invention in detail below in conjunction with embodiment and experimental example, but protection domain is not limited thereto.
embodiment 1a kind of ointment for treating bone fracture and injury, is prepared from (every part of 10g) primarily of following bulk drugs: Pheretima 5 parts, Radix Notoginseng 3 parts, Oletum Trogopterori 2 parts, Rhizoma Cimicifugae charcoal 6 parts, Rhizoma Corydalis 5 parts, Bulbus Allii Fistulosi 3 parts, 2 parts, Radix Rumicis Japonici, Radix Melandrii szechuanensis 4 parts, Radix Aconiti Kusnezoffii 6 parts, Cortex cercis chinensis 6 parts, Herba Erodii 4 parts, Semen setariae is appropriate.
The preparation method of above-mentioned a kind of ointment for treating bone fracture and injury is:
(1) get Radix Aconiti Kusnezoffii to clean, after flooding a night with Sucus Zingberis, take out with the Semen sojae atricolor of its quality 0.4 times with boiling, boil to Radix Aconiti Kusnezoffii well-done, take out, cool completely, section, dries;
(2) after frying pan big fire being heated, be sprinkled into Testa Tritici skin, after smoldering, add clean Cortex cercis chinensis, stir-fry fast 5 minutes, then spray the mature vinegar of Cortex cercis chinensis quality 0.3 times, mix thoroughly, Guan Huo, slightly vexed, take out, sieve removes wheat bran, dries in the air cool;
(3) Oletum Trogopterori is picked clean impurity, rinse well, dry in the air to surperficial and put into mortar, smash to pieces without after the globule, then the Chinese liquor adding as Oletum Trogopterori quality 4 times grinds together, grind and grind stopping completely to Oletum Trogopterori, obtain mixed liquor;
(4) by Radix Notoginseng, Rhizoma Corydalis, Bulbus Allii Fistulosi, Radix Rumicis Japonici, Radix Melandrii szechuanensis and Herba Erodii removing impurity, clean, after the warm water (6 times that the amount of water is boiled crude drug quality) reinstating 40 DEG C with step (1) (2) made crude drug one soaks 20 minutes, pour in non iron container, big fire is heated to boiling, then step (3) made mixed liquor is added, again turn little fire after boiling and decoct 20 minutes, filter, collect filtrate, by the Pheretima of pulverizing and Rhizoma Cimicifugae charcoal, join in filtrate and stir, to be condensed into relative density be 1.14(60 DEG C in heating) clear paste;
(5) get Semen setariae and add decocting in water to medium well, pull out, be ground into Semen setariae end, the Semen setariae end that qinghuo reagent quality is 0.3 times mixes with step (4) made clear paste, obtains ointment for treating bone fracture and injury.
embodiment 2a kind of ointment for treating bone fracture and injury, is prepared from (every part of 10g) primarily of following bulk drugs: Pheretima 10 parts, Radix Notoginseng 6 parts, Oletum Trogopterori 4 parts, Rhizoma Cimicifugae charcoal 9 parts, Rhizoma Corydalis 9 parts, Bulbus Allii Fistulosi 6 parts, 5 parts, Radix Rumicis Japonici, Radix Melandrii szechuanensis 8 parts, Radix Aconiti Kusnezoffii 9 parts, Cortex cercis chinensis 9 parts, Herba Erodii 8 parts, Semen setariae is appropriate.
A kind of preparation method of ointment for treating bone fracture and injury is:
(1) get Radix Aconiti Kusnezoffii to clean, after flooding a night with Sucus Zingberis, take out with the Semen sojae atricolor of its quality 0.4 times with boiling, boil to Radix Aconiti Kusnezoffii well-done, take out, cool completely, section, dries;
(2) after frying pan big fire being heated, be sprinkled into Testa Tritici skin, after smoldering, add clean Cortex cercis chinensis, stir-fry fast 5 minutes, then spray the mature vinegar of Cortex cercis chinensis quality 0.3 times, mix thoroughly, Guan Huo, slightly vexed, take out, sieve removes wheat bran, dries in the air cool;
(3) Oletum Trogopterori is picked clean impurity, rinse well, dry in the air to surperficial and put into mortar, smash to pieces without after the globule, then the Chinese liquor adding as Oletum Trogopterori quality 6 times grinds together, grind and grind stopping completely to Oletum Trogopterori, obtain mixed liquor;
(4) by Radix Notoginseng, Rhizoma Corydalis, Bulbus Allii Fistulosi, Radix Rumicis Japonici, Radix Melandrii szechuanensis and Herba Erodii removing impurity, clean, after the warm water (9 times that the amount of water is boiled crude drug quality) reinstating 40 DEG C with step (1) (2) made crude drug one soaks 20 minutes, pour in non iron container, big fire is heated to boiling, then step (3) made mixed liquor is added, again turn little fire after boiling and decoct 40 minutes, filter, collect filtrate, by the Pheretima of pulverizing and Rhizoma Cimicifugae charcoal, join in filtrate and stir, to be condensed into relative density be 1.26(60 DEG C in heating) clear paste;
(5) get Semen setariae and add decocting in water to medium well, pull out, be ground into Semen setariae end, the Semen setariae end that qinghuo reagent quality is 0.3 times mixes with step (4) made clear paste, obtains ointment for treating bone fracture and injury.
Model case: xxx, man, 21 years old.Main suit: with classmate play basketball run time, accidentally knocked down, when landing, left arm first lands, and self-induction pain can be born at that time, continue again to play ball, rear pain increases the weight of, and elbow joint can not bend, and then checks with regard to Hospital, initial guess fracture or soft tissue contusion, X sheet shows, and left arm humerus has crackle, is diagnosed as fracture.
Use a kind of ointment for treating bone fracture and injury of the present embodiment gained, massage affected part gently, then ointment is applied in affected part, within every 24 hours, change a medicine, 7 days courses for the treatment of.Use after 3 days, upper arm is subsided a swelling, pain relief, can be movable by a small margin, and after using a course for the treatment of, patient can pick up thing, and after using two courses for the treatment of, freely, check X sheet display crackle disappears the activity of patient's left upper arm, and patient fully recovers, and follows up a case by regular visits to, do not have sequela in 1 year.
embodiment 3a kind of ointment for treating bone fracture and injury, is prepared from (every part of 10g) primarily of following bulk drugs: Pheretima 6 parts, Radix Notoginseng 4 parts, Oletum Trogopterori 2.5 parts, Rhizoma Cimicifugae charcoal 7 parts, Rhizoma Corydalis 6 parts, Bulbus Allii Fistulosi 4 parts, 3 parts, Radix Rumicis Japonici, Radix Melandrii szechuanensis 5 parts, Radix Aconiti Kusnezoffii 7 parts, Cortex cercis chinensis 7 parts, Herba Erodii 5 parts, Semen setariae is appropriate.
A kind of preparation method of ointment for treating bone fracture and injury is:
(1) get Radix Aconiti Kusnezoffii to clean, after flooding a night with Sucus Zingberis, take out with the Semen sojae atricolor of its quality 0.4 times with boiling, boil to Radix Aconiti Kusnezoffii well-done, take out, cool completely, section, dries;
(2) after frying pan big fire being heated, be sprinkled into Testa Tritici skin, after smoldering, add clean Cortex cercis chinensis, stir-fry fast 5 minutes, then spray the mature vinegar of Cortex cercis chinensis quality 0.3 times, mix thoroughly, Guan Huo, slightly vexed, take out, sieve removes wheat bran, dries in the air cool;
(3) Oletum Trogopterori is picked clean impurity, rinse well, dry in the air to surperficial and put into mortar, smash to pieces without after the globule, then the Chinese liquor adding as Oletum Trogopterori quality 4 times grinds together, grind and grind stopping completely to Oletum Trogopterori, obtain mixed liquor;
(4) by Radix Notoginseng, Rhizoma Corydalis, Bulbus Allii Fistulosi, Radix Rumicis Japonici, Radix Melandrii szechuanensis and Herba Erodii removing impurity, clean, after the warm water (7 times that the amount of water is boiled crude drug quality) reinstating 40 DEG C with step (1) (2) made crude drug one soaks 20 minutes, pour in non iron container, big fire is heated to boiling, then step (3) made mixed liquor is added, again turn little fire after boiling and decoct 25 minutes, filter, collect filtrate, by the Pheretima of pulverizing and Rhizoma Cimicifugae charcoal, join in filtrate and stir, to be condensed into relative density be 1.16(60 DEG C in heating) clear paste;
(5) get Semen setariae and add decocting in water to medium well, pull out, be ground into Semen setariae end, the Semen setariae end that qinghuo reagent quality is 0.3 times mixes with step (4) made clear paste, obtains ointment for treating bone fracture and injury.
Model case: xxx, female, 36 years old.Wear high-heel shoes when going downstairs, accidentally step on sky, throw from stair, cause right ankle injured, ankle arthrosis place pain, but still can walk, after going home, instep is micro-swollen, after safflower oil massage, pain is slightly alleviated, instep swelling in second day is obvious, and hurt like hell, can not walk, then deliver to examination in hospital, be diagnosed as soft tissue sprain.
Use a kind of ointment for treating bone fracture and injury of the present embodiment gained, massage affected part gently, then ointment is applied in affected part, within every 24 hours, change a medicine, 7 days courses for the treatment of.Use two days later, instep swelling is obviously disappeared, and foot can land, and after using a course for the treatment of, affected part pain disappears, and freely, patient fully recovers, and does not leave sequela in foot activity.
embodiment 4a kind of ointment for treating bone fracture and injury, is prepared from (every part of 10g) primarily of following bulk drugs: Pheretima 9 parts, Radix Notoginseng 5 parts, Oletum Trogopterori 3.5 parts, Rhizoma Cimicifugae charcoal 8 parts, Rhizoma Corydalis 8 parts, Bulbus Allii Fistulosi 5 parts, 4 parts, Radix Rumicis Japonici, Radix Melandrii szechuanensis 7 parts, Radix Aconiti Kusnezoffii 8 parts, Cortex cercis chinensis 8 parts, Herba Erodii 7 parts, Semen setariae is appropriate.
A kind of preparation method of ointment for treating bone fracture and injury is:
(1) get Radix Aconiti Kusnezoffii to clean, after flooding a night with Sucus Zingberis, take out with the Semen sojae atricolor of its quality 0.4 times with boiling, boil to Radix Aconiti Kusnezoffii well-done, take out, cool completely, section, dries;
(2) after frying pan big fire being heated, be sprinkled into Testa Tritici skin, after smoldering, add clean Cortex cercis chinensis, stir-fry fast 5 minutes, then spray the mature vinegar of Cortex cercis chinensis quality 0.3 times, mix thoroughly, Guan Huo, slightly vexed, take out, sieve removes wheat bran, dries in the air cool;
(3) Oletum Trogopterori is picked clean impurity, rinse well, dry in the air to surperficial and put into mortar, smash to pieces without after the globule, then the Chinese liquor adding as Oletum Trogopterori quality 6 times grinds together, grind and grind stopping completely to Oletum Trogopterori, obtain mixed liquor;
(4) by Radix Notoginseng, Rhizoma Corydalis, Bulbus Allii Fistulosi, Radix Rumicis Japonici, Radix Melandrii szechuanensis and Herba Erodii removing impurity, clean, after the warm water (8 times that the amount of water is boiled crude drug quality) reinstating 40 DEG C with step (1) (2) made crude drug one soaks 20 minutes, pour in non iron container, big fire is heated to boiling, then step (3) made mixed liquor is added, again turn little fire after boiling and decoct 35 minutes, filter, collect filtrate, by the Pheretima of pulverizing and Rhizoma Cimicifugae charcoal, join in filtrate and stir, to be condensed into relative density be 1.24(60 DEG C in heating) clear paste;
(5) get Semen setariae and add decocting in water to medium well, pull out, be ground into Semen setariae end, the Semen setariae end that qinghuo reagent quality is 0.3 times mixes with step (4) made clear paste, obtains ointment for treating bone fracture and injury.
embodiment 5a kind of ointment for treating bone fracture and injury, is prepared from (every part of 10g) primarily of following bulk drugs: Pheretima 7.5 parts, Radix Notoginseng 4.5 parts, Oletum Trogopterori 3 parts, Rhizoma Cimicifugae charcoal 7.5 parts, Rhizoma Corydalis 7 parts, Bulbus Allii Fistulosi 4.5 parts, 3.5 parts, Radix Rumicis Japonici, Radix Melandrii szechuanensis 6 parts, Radix Aconiti Kusnezoffii 7.5 parts, Cortex cercis chinensis 7.5 parts, Herba Erodii 6 parts, Semen setariae is appropriate.
A kind of preparation method of ointment for treating bone fracture and injury is:
(1) get Radix Aconiti Kusnezoffii to clean, after flooding a night with Sucus Zingberis, take out with the Semen sojae atricolor of its quality 0.4 times with boiling, boil to Radix Aconiti Kusnezoffii well-done, take out, cool completely, section, dries;
(2) after frying pan big fire being heated, be sprinkled into Testa Tritici skin, after smoldering, add clean Cortex cercis chinensis, stir-fry fast 5 minutes, then spray the mature vinegar of Cortex cercis chinensis quality 0.3 times, mix thoroughly, Guan Huo, slightly vexed, take out, sieve removes wheat bran, dries in the air cool;
(3) Oletum Trogopterori is picked clean impurity, rinse well, dry in the air to surperficial and put into mortar, smash to pieces without after the globule, then the Chinese liquor adding as Oletum Trogopterori quality 5 times grinds together, grind and grind stopping completely to Oletum Trogopterori, obtain mixed liquor;
(4) by Radix Notoginseng, Rhizoma Corydalis, Bulbus Allii Fistulosi, Radix Rumicis Japonici, Radix Melandrii szechuanensis and Herba Erodii removing impurity, clean, after the warm water (7.5 times that the amount of warm water is boiled crude drug quality) reinstating 40 DEG C with step (1) (2) made crude drug one soaks 20 minutes, pour in non iron container, big fire is heated to boiling, then step (3) made mixed liquor is added, again turn little fire after boiling and decoct 30 minutes, filter, collect filtrate, by the Pheretima of pulverizing and Rhizoma Cimicifugae charcoal, join in filtrate and stir, to be condensed into relative density be 1.20(60 DEG C in heating) clear paste;
(5) get Semen setariae and add decocting in water to medium well, pull out, be ground into Semen setariae end, the Semen setariae end that qinghuo reagent quality is 0.3 times mixes with step (4) made clear paste, obtains ointment for treating bone fracture and injury.
The pharmacology of the present invention's main raw material of Chinese medicine used is as follows:
Pheretima: base is former: this product is the dry body of Ju Yin section animal Pheretima aspergillum, popular Pheretimatschiliensis, power simulation or the blind Pheretimatschiliensis of comb.Nature and flavor: salty, cold.Gui Jing: return liver, spleen, urinary bladder channel.Function cures mainly: heat clearing away is calmed the frightened, and dredging collateral, relievings asthma, diuresis.For unconsciousness due to high fever, infantile convulsion is twitched, arthralgia, numb limbs and tense tendons, hemiplegia, dyspnea and cough due to lung-heat, oliguria edema, hypertension.
Radix Notoginseng: base is former: be the root of araliad Panax pseudoginseng.Nature and flavor: sweet micro-hardship, temperature.Gui Jing: enter liver, stomach, large intestine channel.Function cures mainly: hemostasis, dissipating blood stasis, detumescence, analgesic therapy.Control haematemesis, hemoptysis, epistaxis, have blood in stool, dysentery, metrorrhagia, lump in the abdomen, puerperal blood faints, retention of lochia, fall and flutter blood stasis, traumatic hemorrhage, carbuncle pain.
Oletum Trogopterori: base is former: be the dry feces of flying squirrel section animal trogopterus xanthipes and flying squirrel etc.Nature and flavor: bitter in the mouth, sweet, warm in nature.Gui Jing: liver, spleen channel.Function cures mainly: promoting blood circulation and stopping pain, removing stasis to stop bleeding, and removing food stagnancy detoxifies.The all pains of main trusted subordinate's vim and vigour, women's amenorrhea, the stagnant stomachache of the stasis of blood in puerperal, metrostaxis, infantile malnutrition, snakes and scorpions centipete bite.
Rhizoma Cimicifugae charcoal: base is former: be the root stock of ranunculaceae plant Rhizoma Cimicifugae, Cimicifuga Dahurica and C.heracleifolia.Getting Rhizoma Cimicifugae sheet puts in pot, heats with high heat, fries to surface coke black, inner sepia, and spray clear water is a little, and go out most Mars, and taking-up is dried.Nature and flavor: pungent, micro-sweet, are slightly cold.Gui Jing: return lung, spleen, stomach, large intestine channel.Function cures mainly: deliver rash, heat-clearing and toxic substances removing, elevate a turnable ladder yang-energy.For headache due to pathogenic wind-heat, toothache, aphtha, laryngopharynx swelling and pain, measles without adequate eruption, YANG toxin syndrome sends out speckle; Proctoptosis, uterine prolapse.
Rhizoma Corydalis: base is former: be the tuber of papaveraceae plant corydalis.Nature and flavor: pungent, bitter, temperature.Gui Jing: enter liver, stomach warp.Function cures mainly: invigorate blood circulation, and dissipating blood stasis is regulated the flow of vital energy, pain relieving.Control all pains of trusted subordinate's waist knee joint, menoxenia, lump in the abdomen, metrorrhagia, puerperal blood faints, lochiorrhea, traumatic injury.
Bulbus Allii Fistulosi: base is former: be the bulb of liliaceous plant Herba Alii fistulosi.Nature and flavor: pungent, temperature.Gui Jing: enter lung, stomach warp.Function cures mainly: deliver, and activates yang, removing toxic substances.The cold and heat that cure the wound are had a headache, and YIN-cold is suffered from abdominal pain, malnutrition due to parasitic infestation internal resistance, constipation and anuresis, dysentery, carbuncle.
Radix Rumicis Japonici: base is former: be the root of polygonaceae plant Radix Rumicis Japonici or Nepal's Radix Rumicis Japonici.Nature and flavor: bitter, cold, slightly poisonous.Gui Jing: " book on Chinese herbal medicine brief points ": " enter meridian of Hand-SHAO YIN." function cures mainly: heat clearing away, relieving constipation, diuretic, hemostasis, parasite killing.Control constipation due to dry stool, stranguria with turbid discharge, jaundice, spit blood, hemorrhoidal hamorrhage, dysfunctional uterine hemorrhage, tinea alba, scabies, carbuncle, traumatic injury.
Radix Melandrii szechuanensis: base is former: be the root of pinkwort Radix Melandrii szechuanensis.Nature and flavor: pungent, bitter, cool, poisonous.Gui Jing: lung, kidney channel.Function cures mainly: heat clearing away, pain relieving, relieving stranguria by diuresis.Control cough due to lung-heat, rheumatic ostalgia, stomachache, trauma pain, gonorrhea.
Radix Aconiti Kusnezoffii: base is former: be the tuber of ranunculaceae plant Aconitum carmichjaelii Debx. (wild species), Aconitum kusnezoffii Reichb or other multiple congeners.Nature and flavor: pungent, heat, poisonous.Gui Jing: enter liver, spleen, lung meridian.Function cures mainly: search wind prevailing over dampness, and dispersing cold for relieving pain opens expectorant, detumescence.Control anemofrigid-damp arthralgia, paralysis due to windstroke, tetanus, wind syndrome of head, coldness and pain in the epigastrium, accumulation of phlegm in the hypochondrium, air parcel, cold-dysentery, sore throat, carbuncle, furuncle, scrofula.
Cortex cercis chinensis: base is former: be the bark of leguminous plant cercis.Nature and flavor: bitter are flat.Gui Jing: 1. " the southern regions of the Yunnan Province book on Chinese herbal medicine ": " enter liver, spleen two warp." 2. " detailed outline ": " starts with, sufficient cloudy blood system of fainting." function cures mainly: promoting blood circulation to restore menstrual flow, subduing swelling and detoxicating.Control anemofrigid-damp arthralgia, women's amenorrhea, vim and vigour pain, sore throat, drench disease, carbuncle, tinea scabies, traumatic injury, snake bite and insect sting.
Herba Erodii: base is former: be the herb of the band fruits such as MangNiu Er Seedling section Mang cattle Seedling platymiscium Mang cattle Seedling and Geranium plant Herba Erodii, Carolina Cranesbill Herb.Nature and flavor: bitter, micro-pungent are flat.Gui Jing: return liver, large intestine channel.Function cures mainly: expelling wind and activating blood circulation, clearing away heat-damp and promoting diuresis.Cure mainly rheumatic arthralgia, numbness of the skin, muscles and bones is miserable, and traumatic injury is had loose bowels, dysentery, sore.
Semen setariae: nature and flavor: sweet, salty, cool in nature.Gui Jing: enter kidney, spleen, stomach warp.Function cures mainly: have invigorating the spleen and regulating the stomach, tonification is deficient, and middle kidney tonifying, heat extraction, and effect of removing toxic substances cures mainly taste deficiency-heat, regurgitation is vomitted, quenches one's thirst, had loose bowels.
test example 1the clinical practice of a kind of ointment for treating bone fracture and injury (embodiment 5) of gained of the present invention:
Clinical data: in February ,-2014 in October, 2012, filters out 443 routine patients in the patient of 6 hospital orthopedics outpatient services treatment, wherein women 208 example, male 235 example, age 15-60 year, 36.3 ± 4.2 years old mean age.Wherein closed fracture 128 example, soft tissue strain and contusion 136 example, knife injury 63 example, dislocation 116 example.All experimenter's damages occur in less than 3 days, and Informed Consent Form affixed one's name to by mirror.Discharge standard: 1, gestation or women breast-feeding their children, allergic constitution or those who are allergic to this drug; 2, can to discontinue medication immediately person because taking other associated therapy medicines for a long time; 3, other diseases has influence on damage local application; 4, fracture or muscle tendon ligament fracture person completely; 5, the severe primary diseases such as cardiovascular cerebrovascular Liver and kidney and hemopoietic system are associated with, psychotic; 6, the patient of other clinical trials is participated in.
Test method: patient is divided into two groups at random, experimental group 273 example and matched group 170 routine, two groups in sex, age, the course of disease, the state of an illness etc. without significant difference (P > 0.05), there is comparability.Two groups of fracture patients all after maneuver or operative reduction to being fixed.Experimental group uses products obtained therefrom of the present invention, massages affected part gently, then ointment is applied in affected part, and within every 24 hours, change a medicine, 7 days courses for the treatment of, matched group uses other medicine, as conventional medication such as YUNNAN BAIYAO cream, traumatic injury subsides, Zhenjiang plaster.Treatments period carries out Continuous Observation to two groups of patients, record affected part swelling and recovery situation.After treating two courses for the treatment of, add up the therapeutic outcome of soft tissue strain and contusion in two groups, knife injury, dislocation patient, after treating four courses for the treatment of, add up the therapeutic outcome of two groups of fracture patients.
Curative effect situation criterion: 1, fracture: cure: fracture site is without tenderness, and without longitudinal percussion pain, fracture end is without bony crepitus, and X-ray film display fracture line is fuzzy, has a large amount of callus formation, functional rehabilitation, and limbs can be freely movable; Effective: the malaise symptoms such as swelling and pain alleviates, fracture site has a small amount of callus formation, and limb activity still has dysfunction; Invalid: pain and swelling malaise symptoms is unchanged, and fracture is without callus formation.
2, soft tissue injury: cure: affected part is red, swollen, pain disappears, functional rehabilitation, limbs can be freely movable; Effective: red, swollen, pain obviously alleviates, and limb activity still has dysfunction; Invalid: red, swollen, pain is without any improvement.
3, knife injury: cure: pain, swelling disappear, wound healing; Effective: pain, swelling obviously alleviate, wound surface takes a turn for the better; Invalid: pain, swelling, wound surface are all without improvement.
4, dislocate: cure: congestive edema, pain disappear, dislocation position can be freely movable, recovery from illness; Effective: subsiding a swelling completely in dislocation position, but still has pain; Invalid: pain congestive edema is without any change.
Table 1 liang group patient treatment outcome
Therapeutic outcome (seeing table 1) from two groups of patients: the total effective rate of experimental group is 98.2%, the total effective rate of matched group is 83.5%, and the therapeutic effect of visible matched group is starkly lower than experimental group.Illustrate that products obtained therefrom of the present invention has significant therapeutic effect to traumatic injury.
The Pheretima of dredging collateral diuresis is had, the Radix Notoginseng of hemostasia and detumescence, the Oletum Trogopterori of promoting blood circulation and stopping pain in formula of the present invention, the Rhizoma Cimicifugae charcoal of heat-clearing and toxic substances removing, the Rhizoma Corydalis of eliminating stasis to stop pain, the Bulbus Allii Fistulosi delivered of activating yang, the Radix Rumicis Japonici of hemostasis parasite killing, the Radix Melandrii szechuanensis of clearing away heat to alleviate pain, the Radix Aconiti Kusnezoffii of dispersing cold for relieving pain, the Cortex cercis chinensis of promoting blood circulation to remove obstruction in the collateral, the Herba Erodii of expelling wind and activating blood circulation, the use of multiple medical material, makes the present invention have the effect of blood circulation promoting and blood stasis dispelling, eliminating stasis to stop pain, hemostasia and detumescence, has comparatively significant curative effect to the treatment of traumatic injury.
It should be pointed out that detailed description of the invention is the more representational example of the present invention, obvious technical scheme of the present invention is not limited to above-described embodiment, can also have a lot of distortion.Those of ordinary skill in the art, with the present invention clear and definite disclosed or according to undoubted the obtaining of the written description of file, the claimed scope of this patent all should be thought.
Claims (10)
1. an ointment for treating bone fracture and injury, is characterized in that, is prepared from primarily of following bulk drugs, is mass parts: Pheretima 5-10, Radix Notoginseng 3-6, Oletum Trogopterori 2-4, Rhizoma Cimicifugae charcoal 6-9, Rhizoma Corydalis 5-9, Bulbus Allii Fistulosi 3-6, Radix Rumicis Japonici 2-5, Radix Melandrii szechuanensis 4-8, Radix Aconiti Kusnezoffii 6-9, Cortex cercis chinensis 6-9, Herba Erodii 4-8, Semen setariae is appropriate.
2. a kind of ointment for treating bone fracture and injury as claimed in claim 1, is characterized in that, Pheretima 6-9, Radix Notoginseng 4-5, Oletum Trogopterori 2.5-3.5, Rhizoma Cimicifugae charcoal 7-8, Rhizoma Corydalis 6-8, Bulbus Allii Fistulosi 4-5, Radix Rumicis Japonici 3-4, Radix Melandrii szechuanensis 5-7, Radix Aconiti Kusnezoffii 7-8, Cortex cercis chinensis 7-8, Herba Erodii 5-7, Semen setariae is appropriate.
3. a kind of ointment for treating bone fracture and injury as claimed in claim 1, is characterized in that, Pheretima 7.5, Radix Notoginseng 4.5, Oletum Trogopterori 3, Rhizoma Cimicifugae charcoal 7.5, Rhizoma Corydalis 7, Bulbus Allii Fistulosi 4.5, Radix Rumicis Japonici 3.5, Radix Melandrii szechuanensis 6, Radix Aconiti Kusnezoffii 7.5, Cortex cercis chinensis 7.5, and Herba Erodii 6, Semen setariae is appropriate.
4. the preparation method of a kind of ointment for treating bone fracture and injury as described in as arbitrary in claim 1-3, it is characterized in that, step is:
(1) get Radix Aconiti Kusnezoffii to clean, after flooding a night with Sucus Zingberis, take out with Semen sojae atricolor with boiling, boil to Radix Aconiti Kusnezoffii well-done, take out, cool completely, section, dries;
(2) after frying pan big fire being heated, be sprinkled into Testa Tritici skin, after smoldering, add clean Cortex cercis chinensis, stir-fry fast 5 minutes, then spray mature vinegar, mix thoroughly, Guan Huo, slightly vexed, take out, sieve removes wheat bran, dries in the air cool;
(3) Oletum Trogopterori is picked clean impurity, rinse well, to dry in the air to surface without after the globule, put into mortar, smash to pieces, then add Chinese liquor and grind together, grind and grind stopping completely to Oletum Trogopterori, obtain mixed liquor;
(4) by Radix Notoginseng, Rhizoma Corydalis, Bulbus Allii Fistulosi, Radix Rumicis Japonici, Radix Melandrii szechuanensis and Herba Erodii removing impurity, clean, reinstate the warm water soaking of 40 DEG C after 20 minutes with step (1) (2) made crude drug one, pour in non iron container, big fire is heated to boiling, then add step (3) made mixed liquor, again turn little fire after boiling and decoct 20-40 minute, filter, collect filtrate, by the Pheretima of pulverizing and Rhizoma Cimicifugae charcoal, join in filtrate and stir, heating is condensed into clear paste;
(5) get Semen setariae and add decocting in water to medium well, pull out, be ground into Semen setariae end, the Semen setariae end that qinghuo reagent quality is 0.3 times mixes with step (4) made clear paste, obtains ointment for treating bone fracture and injury.
5. the preparation method of a kind of ointment for treating bone fracture and injury as claimed in claim 4, is characterized in that, the amount of step (1) Semen sojae atricolor is 0.4 times of Radix Aconiti Kusnezoffii quality.
6. the preparation method of a kind of ointment for treating bone fracture and injury as claimed in claim 4, is characterized in that, the amount of step (2) mature vinegar is 0.3 times of Cortex cercis chinensis quality.
7. the preparation method of a kind of ointment for treating bone fracture and injury as claimed in claim 4, is characterized in that, the amount of step (3) Chinese liquor is the 4-6 of Oletum Trogopterori quality doubly (preferred, the amount of Chinese liquor is 5 times of Oletum Trogopterori quality).
8. the preparation method of a kind of ointment for treating bone fracture and injury as claimed in claim 4, is characterized in that, doubly (preferred, the 7-8 that the amount of warm water is boiled crude drug quality doubly for the 6-9 that the amount of step (4) warm water is boiled crude drug quality; Be more preferably, 7.5 times that the amount of warm water is boiled crude drug quality).
9. the preparation method of a kind of ointment for treating bone fracture and injury as claimed in claim 4, is characterized in that, step (4) turns little fire and decocts 25-35 minute (preferred, again to turn little fire after boiling and decoct 30 minutes) after again seething with excitement.
10. the preparation method of a kind of ointment for treating bone fracture and injury as claimed in claim 4, is characterized in that, the relative density of step (4) clear paste is 1.14-1.26(60 DEG C) (preferred, the relative density of clear paste is 1.16-1.24; Be more preferably, the relative density of clear paste is 1.20).
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| CN102908414A (en) * | 2012-11-15 | 2013-02-06 | 朱继峰 | External use plaster for treating fracture and traumatic injury |
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| CN1362256A (en) * | 2001-12-26 | 2002-08-07 | 邹明义 | Osteological Chinese medicine prepn. |
| CN102302565A (en) * | 2011-09-15 | 2012-01-04 | 上海交通大学医学院附属新华医院 | Stasis eliminating powder for treating soft tissue injury and cervical spondylosis |
| CN102908414A (en) * | 2012-11-15 | 2013-02-06 | 朱继峰 | External use plaster for treating fracture and traumatic injury |
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