CN104666330B - Pure chlorine dioxide solution prepares the application of interior disinfectant - Google Patents
Pure chlorine dioxide solution prepares the application of interior disinfectant Download PDFInfo
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Abstract
The present invention relates to field of medicaments, it is interior by the use of disinfectant be as medicine, available for the suction of oral, respiratory tract aerosol, intravenous injection.The clinical practice of the present invention, it is the new approaches of therapeutic scheme for the disease caused by pathogenic microorganisms；Interior with the main component of disinfectant is certain concentration pure chlorine dioxide solution, it is corresponding with disinfectant for external use interior to use disinfectant, it can be used alone or be used in combination with other drugs, it is interior to be treated or auxiliary treatment includes but is not limited to rhinitis, sphagitis, pneumonia, pneumoconiosis, pulmonary tuberculosis etc. with the suction of disinfectant respiratory tract aerosol；And the city dweller respiratory health purposes serious as air pollution, discharged by phlegm, clean lung's smoke puff and dust；Oral interior disinfectant can treat including but not limited to halitosis, the stomach trouble of helicobacter pylori infections.
Description
Technical field：
It is the pure chlorine dioxide solution of certain concentration the present invention relates to field of medicaments, is noted with oral, aerosol suction, vein
The method penetrated uses, for the new departure used for the killing of certain pathogenic microorganisms.In corresponding with disinfectant for external use
With disinfectant, it can be used alone or be used in combination with other drugs.
Background technology：
It is the pure titanium dioxide of research that I, which devised pure chlorine dioxide generator (patent No. ZL 01205297.3) in 2001,
Solutions of chlorine property it is the first, it would be desirable to solve the problem in use；By the repetition test of 6 months, solves chlorine dioxide
The labile problem of solution, it was found that the method that pure chlorine dioxide solution preserves for a long time, but pack, storage, transport requirement with
Cost is too high, is not suitable for the market demands of disinfectant, in November, 2003, the company that I controls interest, in the project heavy losses
In the case of, abandon the project construction of pure chlorine dioxide solution.From in April, 2014, it is molten that I manufactures pure chlorine dioxide again
Liquid simultaneously studies it in medicinal possibility, and I am once continuous up to 15 days to drink 50ml, concentration 100-130mg/l and up to 30
It continuously drinks 300ml, concentration 40mg/l pure chlorine dioxide solution experience, and sucks the pure of 25mg/l concentration using aerosol
The experiment of ClO 2 solution 5 days, and stomach trouble is effected a radical cure to 2 helicobacter pylori infections volunteer patients, to pure chlorine dioxide solution
Medicinal possibility is very confident.
The history and the general character of chlorine dioxide：Chlorine dioxide (ClO2) it is that Humphrey Dai Wei had found in 1811.According to
The difference of concentration, chlorine dioxide are a kind of yellow greens to orange-yellow gas.When dense, there is the excitant similar to chlorine
Smell, when concentration is extremely low, there is grass smell and slight sweet taste.When concentration is less than 500ppm, its shadow to human body
Sound can be ignored, and any influence, including the influence in terms of Physiology and biochemistry will not be produced during below 100ppm to human body, to skin
Also without any sensitization and stimulation.In fact, the conventional concentration of chlorine dioxide will be well below 500ppm, normally only
In tens ppm or so.Therefore, chlorine dioxide is also known as the safe and nontoxic green disinfectant (A1 with water peer in the world
Level), it is described as " chlorine dioxide is that God gives the mankind most sincere present ".
Chlorine dioxide (ClO2) it is a kind of brownish red gas, low concentration is yellow green gas, and relative atmospheric proportion is 1.1,
It is heavier than air.Liquid specific gravity 2.37, there is the penetrating odor similar to chlorine；100ppm chlorine dioxide (ClO2) aqueous solution, tool
There are grass smell and slight sweet taste, chlorine dioxide (ClO2) 11 DEG C of boiling point, -59 DEG C of freezing point.Soluble in water, glacial acetic acid and four
Chlorination carbon equal solvent.Liquefaction chlorine dioxide and high concentration of chlorine dioxide are extremely unstable, hit or solar radiation can explode.
In atmosphere, concentration may explode more than 10%, be the material of excellent stability less than 10%, the danger do not exploded
Danger.
Chlorine dioxide toxicity is more much smaller than chlorine, ozone, in air, chlorine gas concentration 1.2mg/m3, ozone 1.6mg/
m3, acute headache, even dead is just presented in people；And pure chlorine dioxide is less than 120mg/m3Concentration, it will not occur above-mentioned
Dangerous phenomenon.Chlorine dioxide stability is higher than ozone, and in air, ozone just decomposes at 18 DEG C, and chlorine dioxide is less than 35
DEG C it will not decompose.
Chlorine dioxide is soluble in water, and solubility is 5 times of chlorine, under room temperature 30mm/Hg partial pressures, solubility 2.9g/
L；In room temperature 760mm/Hg pressure (normal pressure), solubility 3.1g/L.Chlorine dioxide is not easy to be hydrolyzed, with monomolecular in water
Formed and existed, at low concentrations (below 10mg/L), it is sterilized, disinfecting power, is mainly carried out in a manner of oxidation, is killed with chlorine
Bacterium sterilization is different, and disinfection by chlorine is carried out in a manner of electronics shifts.Therefore ClO2Killing mattress can be interior (2~10) in a big way in pH value
Efficient sterilization, and it is harmless.
ClO in water after testing2When below 1mg/L concentration contrast 1mg/L chlorine kill mattress ability more than more than 5 times (
Under various media, the corresponding time killed, residual bacterium number amount, ClO in the conclusion and existing literature drawn is compareed2Sterilizing ability is by having
Effect chlorine is more than Cl22.6 times of data there is any discrepancy).
Influence ClO2Sterilizing ability factor：
It is dysgenic to it to be：Cl2Or corresponding ClO-Ion, ClO2-、ClO3-。
Producing facilitation to it is：Dissolved oxygen, H2O2、Fe2+Ion, Cl-。
On it influential is not：CO3 2-、Na+、Ca2+。
The definition of pure chlorine dioxide solution refers to not calculate CO3 2-The aqueous solution of chlorine dioxide of ion concentration, purity exceed
99%.
Physicochemical properties
The structural formula of chlorine dioxide：Angle between 2 O and Cl two double bonds is 117.7 ° ± 1.72 °, 2 O and Cl it
Between distance it is equal, i.e. D=1.784+0.01A.
The infrared spectrum of chlorine dioxide：υ1945cm-1；υ2445cm-1；υ31108cm-1。
UV absorption of the chlorine dioxide in carbon tetrachloride：λ max375nm and 355nm, there is a weak suction at 263nm
Receive.
Chlorine dioxide is with AB2Resonant structure exist.
The electronic structure of Chlorine Dioxide Molecules is in undersaturated condition, but in water, is not existed with dimerization or poly state but,
This rapid diffusion to chlorine dioxide in water is favourable.Chlorine dioxide is more sensitive to light.The titanium dioxide dissolved in water
Chlorine, the photodissociation quantum rate at 436nm is 0.20mol/E, 1.0mol/E is risen at 405nm, its mechanism is as follows：
2ClO2+ h υ=2ClO1-+2O
ClO+H2O=H2ClO2
H2ClO2+ ClO=HClO3+HCl
2ClO2+hυ+H2O=HClO3+HCl+2O
Therefore, in actual applications, chlorine dioxide must be kept in dark place.
In theory, chlorine dioxide should be the acid anhydrides of chlorous acid and chloric acid, i.e. 2ClO2+H2O=HClO2+HClO3, still,
Under the conditions of actual water process, when pH value is 6~8, chlorine dioxide but has larger stability in water, and its concentration can be stablized
More than 48h, this can be seen from：
During 20 DEG C of water temperature, [HClO2][HClO3]/[ClO2]2=1.2 × 10-7。
Only under the alkalescence condition of pH >=9, disproportionated reaction just occurs for chlorine dioxide：
2ClO2+2OH-=ClO2-+H2O
To ClO2The influence factor of oxidability
With negative reaction factor：Cl2Or corresponding ClO-Ion, ClO2-、ClO3-。
Factor with promotion：Dissolved oxygen, H2O2, Fe2+Ion, Cl-。
The factor not had an impact to it：CO3 2-、Na+、Ca+2Plasma.
Chlorine dioxide (ClO2) corrosivity is very strong, in use, it is impossible to contacted with metal object.
It is soluble：Water is highly soluble in without being reacted with water, is hardly hydrolyzed, the solubility in water is the 5-8 of chlorine
Times.It is dissolved in aqueous slkali and generates chlorite.
Using pure chlorine dioxide (ClO2) mode of gas absorption determines, chlorine dioxide (ClO2) solubility in water：20℃
When 2300mg/L；The reason for this is not reacted completely under remaining carbon dioxide air lift effect, and solubility declines.
Advantage：
1. broad spectrum activity：Virus, bacterium, protist, algae, fungi and various spores and the thalline of sporogenesis can be killed
It is 2. efficient：All virus breeding bodies and many Causative virus can be killed under 0.1ppm, 5ppm can be killed carefully completely
Bacterium brood body, hepatitis viruse, bacteriophage and bacterial spore
3. influenceed by temperature and ammonia small：Fungicidal effectiveness is basically identical under low temperature and higher temperature
4.pH is applied widely：Very high germicidal efficiency can be kept in the range of pH2-10
5. safe noresidue：Chlorination does not occur with organic matter, do not produce three cause materials and other noxious materials
6. the advantages that pair human body is non-stimulated：During less than 500ppm, its influence can be ignored, and below 100ppm does not have any to people
Influence security
External substantial amounts of experimental study shows that chlorine dioxide is safe and nontoxic disinfectant, nothing " three cause " effect (carcinogenic,
Teratogenesis, mutagenesis), while also can not produce having for " three-induced effect " with organic matter generation chlorination generation in disinfecting process
Machine chloride or other poisonous class materials.But because chlorine dioxide has extremely strong oxidability, (the ＞ in high concentration should be avoided
500ppm) use.When concentration is less than 500ppm, its influence to human body can be ignored, will not be right during below 100ppm
Human body produces any influence, including the influence in terms of Physiology and biochemistry.To skin also without any sensitization.In fact, two
The conventional concentration of chlorine monoxid will be well below 500ppm, normally only in tens ppm or so.Therefore, chlorine dioxide is also by state
Safe and nontoxic green disinfectant is known as on border.
Zoopery and toxicological profile
Foreign countries draw a conclusion according to toxicologic study, and chlorine dioxide is a kind of toxic compounds, is not absorbed by the skin, and is not easy
A large amount of volumes.The chlorine dioxide of less toxic dosage (the 1/10~1/250 of LD50) is injected in home mouse body in two months and shown
Go out and have an impact to the composition of liver function, blood, and influence reaction of central nervous system function.Utilize a series of the grinding of animal progress
Study carefully work to show, drink the water containing chlorine dioxide for a long time, according to its contained concentration different (usually used concentration is at a relatively high) certainly
2.0mg/L-200mg/L may damage liver, kidney, central nervous system function, influence the composition of peripheral blood, suppress thyroid
Function, the brain development for influenceing newborn young mouse.
In Chinese Disease Control and Prevention Center's toxicological experiment at home, fed through 90 days, chlorine dioxide mixed liquor (ClO2、ClO2-With
ClO3-Concentration be respectively 276.5,165.9 and 110.6mg/L) rat there are no toxicity damage effect.
Two results are obtained in goldfish toxicity test and small white mouse toxicity test：
A. chlorine dioxide (ClO2) long-term living safety concentration be 0.75mg/l；
B. tested by small white mouse acute oral toxicity, ClO2True border nontoxic type.
Acute toxicity test, when highest is filled with dosage 10000mg/kg chlorine dioxide, mouse is still without obvious poisoning symptom, drink
Food and activity are normal.Each group animal none mortality table during experiment.It is computed, its LD50 of passing through mouth ＞ 10000mg/kg.
Acute skin irritation, observation show, coat after medicine 1~48 hour, and rabbit back application site skin does not go out
The existing irritation such as erythema and oedema, reaction integration is 0.
Acute ocular mucous membrane irritation, to after the intracapsular instillation concentration 9.7~11.4mg/L ClO 2 solutions 5s of rabbit conjunctival,
It is clean with normal saline flushing.There is mild hyperaemia in 6h in rabbit conjunctival blood vessel, is disappeared substantially to 24h symptoms, and symptom 48h is complete
It totally disappeared mistake.Rabbit 48h eye irritation score index is 0, belongs to nonirritant material.
I tests the pure chlorine dioxide solution of 120~150ppm concentration, is applied at trauma wounds, contrasts the thorn of running water
Swash property, the excitant of pure chlorine dioxide solution is less than running water, analgesia.
Influence to human body
10 male volunteers drink the water that chlorine dioxide concentration gradually increases and (are followed successively by 0.1,1,5,10,18 and 24mg/
L after), disease is not found in a physiologically.
10 same male volunteers drank the water that 0.5 liter of chlorine dioxide concentration is 5mg/L daily in 12 weeks, then
Continuous Observation within 8 weeks.Blood analysis and urinalysis are no abnormal.
Disinfection effect：Chlorine dioxide is a kind of wide spectrum, efficient bactericidal agent.External many result of study shows,
Chlorine dioxide is under extremely low concentration (0.1ppm), you can kills many Escherichia coli, staphylococcus aureus etc. and causes a disease
Bacterium.Under the interference of organic matter and ammonia, when concentration is 20ppm, bacterial propagule, hepatitis can be also killed completely
The microorganisms such as poison, bacteriophage and bacterial spore, do not find that the virus of 5ppm concentrations above can be resisted, do not find that 20ppm can be resisted
The unicellular microorganism of concentrations above.
Disinfection agent of chlorine dioxide applicating history
Human use's chemosterilant carries out sterilizing since 19 beginnings of the century.First generation chemical disinfection in 1820
After agent bleaching powder comes out, people are mainly used in the treatment of drinking water disinfection and contaminated wound, and are achieved and imitated well
Fruit, open first milestone of chemical sterilization sterilization.Hereafter, people are found that second generation disinfectant oxirane in succession,
Third generation disinfectant glutaraldehyde.Efficient chemical disinfectant of new generation comes out in calling again and again finally, and here it is referred to as the 4th
For the chlorine dioxide of disinfection sanitizer.
After large-scale production, people just start large-scale use.The Big Fall In Niagara in the U.S. in 1940 takes the lead in adopting
Drinking water is handled with it, good result is obtained, is generalized to the whole world rapidly afterwards.Discovery chlorine enters people to drinking water successively
During row sterilization, with chlorine substitution reaction can occur for the organic matter in water, generate organochlorine compound, organochlorine can be in human body inner product
Stay and produce chronic progressive poisoning, can also induce carninomatosis, environmental protection alliance of the world will completely forbid is used for drinking water using chlorine
Sterilization, it is proposed that using the sterilization of universal, the high effect disinfectants chlorine dioxide progress drinking water with strong oxidizing property.Chlorine dioxide
AI levels disinfectant (uniquely with the material of the toxicity ad eundem of water) is classified as by the United Nations's health organization (WHO).
China starts from the eighties using Chloride Dioxide Disinfection Technology.1987, health supervision department of Guangdong Province ratified it
It can be used for food sterilization, fresh-keeping and food apparatus, equipment disinfection.Nineteen ninety Shanghai sanitation approved by management its can be used for
Water process, food processing and aquaculture, deodorization etc..The Ministry of Public Health of China also clearly proposed before 2000, progressively used dioxy
Change chlorine and substitute the sterilization that chlorine carries out drinking water.From 2003, chlorine dioxide is listed in the important of prevention SARS and chloride disappeared again
Toxic agent.
Technical problem existing for Chlorine dioxide production at present：
1st, stability chlorine dioxide must activate before use, react 15 points with sodium chlorite using hydrochloric acid or citric acid
Reaction depth requirement be present and because there is a large amount of chlorine conversions to produce under acid state, produce painful in clock, pH value below 1
Smell.
2nd, the corresponding concentration that is diluted to after activating uses, usually 500ppm；And to be finished in 2 hours；
Even if the 3, professional and technical personnel operates, reaction depth is low, and on the premise of having auxiliary equipment, transformation efficiency is less than
70%；
4th, due to the special nature of chlorine dioxide, in the state of PH is less than 1, conversion ratio could improve, but low PH,
It is Cl that chlorine dioxide, which can be made,2Or corresponding ClO-Ion, ClO2-、ClO3-Deng impurity, these Uncertainty materials have
The composition chlorine forbidden, even if by pure chlorine dioxide solution caused by the absorption of high pure nitrogen stripping, drawn through experiment, this method
After the pure chlorine dioxide solution purity of production is 99.4%, 2 hours, purity is down to 88%；Its stability is very poor；In no dioxy
Change before carbon method pure chlorine dioxide solution comes out, due to the uncertain of the accessory substance of prohibitive composition chlorine and composition be present
Property, it is that impossible be used as medicine oral.
Because the Chlorine dioxide production in market has disadvantage mentioned above, in the case of special, medical worker, cleaner, household
Daily sterilization is unwilling to use Chlorine dioxide production.The pharmacy of the overwhelming majority sells without Chlorine dioxide production, no special feelings
Condition, only Disease Control and Prevention Center's storage stability Chlorine dioxide production are standby, update every year a collection of.
The pure chlorine dioxide solution that the present invention uses, it is already possible to realize in below 500mg/l, chlorine dioxide mode
It is present in the aqueous solution, and interior stabilization preserves more than three months, purity does not decline, and concentration is dropped by less than 5%.
The content of the invention：
The feature of pure chlorine dioxide solution
Early in 2000, professor Wu Yuejun had found, carbon dioxide reacts with sodium chlorite, can be when pH value is neutral
(pH value 5-7) produces pure chlorine dioxide, and I am under the cooperation of Wu professor, the pure chlorine dioxide generator designed, in
Application utility model patent in 2001, the patent No.：ZL 01205297.3, using the method for the patent, it can manufacture containing dioxy
Change the mixed gas of the chlorine dioxide of carbon gas, carbon dioxide does not influence the physicochemical properties of chlorine dioxide, not as impurity
Calculate, the chlorine dioxide is after 2~5 DEG C of low-temperature pure waters are adsorbed, and under the partial pressure of control solution carbon dioxide, highest can be with
The pure chlorine dioxide solution that concentration is 1980ppm is made；In the saturation arbon dioxide solution (28~30g/l of concentration) of normal pressure
Under, the maximum concentration of pure chlorine dioxide solution is 920ppm；Through overtesting, concentration is in below 500mg/l, in specific dioxy
Change under carbon partial pressure, the optimal stability of pure chlorine dioxide solution, under corresponding carbon dioxide and chlorine dioxide concentration ratio, pure two
Oxidation solutions of chlorine will not be converted into the accessory substances such as chlorite, hypochlorite, chlorate anions, but can be escaped with carbon dioxide and take away two
Chlorine body is aoxidized, declines valid density, but do not influence purity；
Disinfectant is used for interior as with pure chlorine dioxide solution, under the following conditions, can meet to require：
1st, react to obtain using the sodium chlorite of purity 92% and the food-grade carbon-dioxide after water washing charcoal absorption
Chlorine dioxide, through pure water absorption method produce pure chlorine dioxide solution.
2nd, capacity of the Brown Glass Brown glass bottles and jars only below 70%；
3rd, carbon dioxide pressurization, pressure are more than or equal to 0.02Mpa；
4th, bottle sealing rubber cushion uses Foamed polyvinylidene fluoride plate or expanded polytetrafluoroethylene plate；
5th, it is stored in 0~5 DEG C of cold compartment of refrigerator；
6th, for pure chlorine dioxide solution below 1000ppm concentration, preferable concentration is below 500ppm.
The interior scheme with disinfectant is used as using pure chlorine dioxide solution：
Interior disinfectant is divided into pharmaceutical grade and injection stage as requested, and the purity of pharmaceutical grade pure chlorine dioxide solution reaches
More than 99.5%, for gas concentration lwevel in 20~30g/l scopes, the concentration of product packaging pure chlorine dioxide is 200mg/l；Orally
The concentration of pure chlorine dioxide solution is controlled before use in 35~50mg/l, when pure chlorine dioxide solution is used for aerosol suction, two
The concentration of chlorine monoxid is controlled in 20~35mg/l before use.
The interior disinfectant of pharmaceutical grade, it can be used for the breathing such as chronic pharyngitis, chronic laryngitis, chronic pneumonia, pneumoconiosis, pulmonary tuberculosis
The auxiliary treatment in road, drawn through experiment, for injury of the health care caused by smoking, PM2.5 dust to lung, the non-convention of effect
Think.
The purity of injection stage pure chlorine dioxide solution reaches more than 99.9%, and the concentration of product packaging pure chlorine dioxide is
800mg/l, carbon dioxide content 35g/l；The content of carbon dioxide is to be controlled using preceding chlorine dioxide concentration in 35mg/l
Hereinafter, gas concentration lwevel control is in 1.5g/l or so；Because the gas concentration lwevel in blood is near 1.3g/l, titanium dioxide
The concentration of carbon is higher than 2.0g/l, may cause human body emergency reaction, and consequence is very serious.Injection is in use, must have precision
Carbon dioxide and the detection device of chlorine dioxide concentration use simultaneously.
The use of injection stage pure chlorine dioxide solution, simply substantial amounts of chlorine dioxide test data support under imagination,
Have to pass through more strict tests, including the Thyroid Hormones Levels to human body, hormonal readiness, body trace element, blood into
Many Index Influence limit values that grade could be applied, including after Causative virus inactivation, human body has also needed to a variety of non-Causative virus
With human body symbiosis, the micro constitutent of human body can just synthesized and reaches proper level, including non-Causative virus rebuilds etc. one
At the time of being only injection stage pure chlorine dioxide solution and formally apply of a whole set of complete scheme.
The interior disinfectant of injection stage, it can be used for AIDS, hepatitis, the mainstay such as leukaemia is controlled caused by virus
Treat.
Embodiment：
Because WHO allows chlorine dioxide directly edible, it is used to move based on WHO and national the Disease Control and Prevention Center chlorine dioxide approved
The great number tested data of thing and human body, I and volunteer are using the process of pure chlorine dioxide solution and the feature of appearance
The impression of oral pure chlorine dioxide solution, 10 milliliters of 150ppm concentration, is tested 2 days, smell is gentle, and tongue has stimulation
Sense is strong, can orally make oral cavity bitter, and can lose the sense of taste, any homogeneous individual taste of food, withdraws 2~3 days aftertastes and recovers, together
When can produce the phenomenon snotty of flu, nasal mucus is in clear water sample, and symptom disappears after oral 2-4 hours.
Using the impression of gargling of pure chlorine dioxide solution, 50~60ppm concentration, oral cavity fresh and cool, but smoke is very when smoking
It is unpleasant, it may be possible to a kind of method of smoking cessation.
The impression of oral pure chlorine dioxide solution, 100 milliliters of 90~100ppm concentration, long run test 15 days, smell is gentle
Stimulate, can orally make astringent sense between oral cavity, teeth space strong, and the sense of taste can be temporarily lost with, any homogeneous individual taste of food, after withdrawing three days
The sense of taste is recovered, while can produce the phenomenon of the clear nasal mucus of stream of flu, and symptom disappears after oral 1-2 hours, more than 2 when during which driving
2 hypoglycemia occur after hour to lose consciousness, swoons 5~10 seconds, recovers after drinking-water.Smoke is unpleasant during smoking, is all the sense of false smoke
Feel.2 dizzinesses occurred during daily life, wherein once survey blood glucose is less than 3.1 and blood pressure is abnormal, it is systolic pressure
125mmHg, diastolic pressure 95mmHg.Somatosensory is easily tired, and muscle power is felt not prop up after half an hour of playing table tennis.
Helicobacter pylori (Helicobacter pylori) abbreviation Hp, the oral pure chlorine dioxide solution of 2 HP volunteer patients
(abbreviation CDS) tests effect：1. first day, oral CDS：50ml@50mg/l；The same day is anti-to smell without sour regurgitation symptom, volunteer
It is strong to reflect nasal cavity excitement, is drunk after addition 5~6ml tea in good taste；2. there is within second day oral CDS after sour regurgitation symptom：200ml@
33mg/l；3. the 3rd day has oral CDS after the belching of gas：250ml@42mg/l；The food of various easily sour regurgitations is attempted after oral 5 days, instead
Sour and heartburn symptom disappears.4. once in the morning and once at night, continuously amount to 10 days oral CDS：2x300ml@35mg/l；Gastric disease symptoms 25 days
Do not occur, during oral and observation, daily life is unaffected, and it is in clear water sample that volunteer patients do not occur to lose the sense of taste and have nasal mucus
The report for thinking that cold symptoms etc. are uncomfortable, the oral concentration should can confirm that as preferable scheme.Surveyed through saliva method urease
Helicobacter pylori is determined for feminine gender.
The interior experiment sucked with disinfectant aerosol：I has 25 years smoking histories, has pharyngo-laryngitis chronica, using pure chlorine dioxide
Solution suction respiratory tract test, takes 10ml@525mg/l pure chlorine dioxide solution, adds 150ml clear water, survey solution chlorine dioxide
Concentration is 28mg/l, is placed in ultrasonic ultrasonic delay line memory, via intranasal application suction water smoke, daily 20 minutes, 5 days altogether, first day, about 6 is small
When after there is dense productive cough to go out, face light yellow complexion pure color；The next morning is waken by dense phlegm, point 2 expectoration about 30ml, with dark brown such as
Smoke puff such as soil is in phlegm skewness, and the chlorine dioxide concentration then tested is between 25~32mg/l, in subsequent a couple of days
Interior not timing, daily 3~4 dense phlegm of expectoration, each amount 6-10ml, the color of phlegm is gradually light, and amount of expectoration tails off after the 5th day,
Lighter.It is uncomfortable without other in addition to having about 10ml clear water sample nasal mucus such as cold symptoms daily, oral Pseudoephedrine class sense
Emit medicine, clear water sample nasal mucus can be to disappear in very short time.Disable after aerosol sucks 6 days to go out without productive cough, subsequent 1 month without cough
Defect.It is interior largely to be disappeared through endoscopy, sphagitis symptom of erythema.If joint antibiotic usage, it should Ke Yigen
Control sphagitis.
Test above, draws to draw a conclusion：
1st, research is found, usual unicellular microorganism inactivates 99.99% in 1 minute in 5.0mg/l chlorine dioxide environment, not
It was found that unicellular microorganism can bear the inactivation of 20mg/l chlorine dioxide, helicobacter pylori is because of " ammonia cloud " caused by urease
Protection under, many medicines are to the ineffective of it, but pure chlorine dioxide solution can realize inactivation, not by caused by urease
" ammonia cloud " influences；Side effect profile phenomenon does not occur, has nasal mucus to think cold symptoms in clear water sample, belongs to human immune system's
Normal reaction, False path bases medicine can be taken and mitigate symptom.
2nd, pure chlorine dioxide solution kills gastral lactic acid bacteria simultaneously, declines food absorption ability, heavy physical labour
After may cause hypoglycemic effect, can after oral CDS mono- hour, pass through keep the skin wet sugar eliminate Hypoglycemic symptoms.
3rd, oral pure chlorine dioxide solution can cure HP patient, continuous 10 days 35~40mg/l of oral 300ml@CDS
Scheme is that the one of which of HP patient is easy and effective, the low-cost, treatment method that has no side effect.
4th, aerosol sucks interior disinfectant, 2 times a day, 20 20~35mg/l of Fen Zhong ＆100ml@every time；It is that auxiliary treatment is exhaled
A kind of method of tract disease is inhaled, plus oral antibiotic, teaching profession's disease pharyngo-laryngitis chronica, and other respiratory tracts can be cured
The auxiliary treatment medication of disease；In the city dweller of heavily contaminated, if using this method, shadow that can be with pollution abatement to health
Ring.
Meaning of the present invention：Chlorine dioxide finds had more than 100 years, is widely used in disinfection of tap water, also has more than 30
The history in year, as high effect disinfectants, its deactivation mechanism to microorganism is now still without final conclusion, in inactivation microorganism
Meanwhile still keep original molecule constant.The interior clinical practice with disinfectant, for the disease caused by Causative virus, treatment
Scheme has new thinking, can be as the function of mainstay or adjuvant drug, and one kind has no side effect, be low-cost, nonreactive medicine
Property, having that progress of the treatment method of substantial amounts of test data to medical science is extremely important, chlorine dioxide belongs to monomolecular substance,
Do not find there is drug-fast microorganism to chlorine dioxide at present.
The invention provides a method that to the radical cure of teaching profession's disease sphagitis, in the serious city of Chinese air pollution
A kind of resident, there is provided new method of respiratory health；Auxiliary treating method of pneumoconiosis etc..
The invention injection stage once passes through experiment, it is allowed to applies, it is likely to for AIDS virus, hepatitis viruse, Ai Bo
Draw the mainstay such as leukaemia caused by viral, virus.
Claims (4)
1. pure chlorine dioxide solution prepares the application of interior disinfectant, it is characterised in that：Disinfectant is used as interior, available for mouth
Clothes, the suction of respiratory tract aerosol, intravenous injection；
It is described it is interior with the main component of disinfectant be pure chlorine dioxide solution, it is impurity not calculate carbonate and carbon dioxide, pure
Degree is more than 99.5%；
The interior pure chlorine dioxide solution with disinfectant is using the sodium chlorite of purity 92% and after water washing charcoal absorption
Food-grade carbon-dioxide react obtained chlorine dioxide, through pure water absorption method produce pure chlorine dioxide solution；
It is described interior to be divided into pharmaceutical comg and injection stage with disinfectant；
It is described it is interior determined with disinfectant using preceding concentration dilution to below 100mg/l, and by strict chlorine dioxide concentration, its
In middle injection stage carbon dioxide concentration determination is needed with disinfectant；
It is described it is interior with the condition of storage of disinfectant be at 1~7 DEG C, and more than 8g/l gas concentration lwevel protection under；
The pure chlorine dioxide solution concentration is in below 500mg/l.
2. pure chlorine dioxide solution according to claim 1 prepares the application of interior disinfectant, it is characterised in that：In described
It is used for orally with disinfectant, chlorine dioxide concentration is between 25~50mg/l, the data through animal experiment and human trial acquirement,
Produced with pathogenic bacteria, Causative virus microorganism and suppress or inactivate as index, and make the autologous drug reaction of human body in the model of permission
In enclosing, including but not limited to halitosis, the stomach trouble of helicobacter pylori infections can be treated；When oral, when patient drinks, mouthfeel is bad,
Allow to add indivisible 5~10ml of tea, greatly improve mouthfeel and have no effect on therapeutic effect.
3. pure chlorine dioxide solution according to claim 1 prepares the application of interior disinfectant, it is characterised in that：In described
Sucked with disinfectant for respiratory tract aerosol, chlorine dioxide concentration is between 25~50mg/l, through animal experiment and human trial
The data of acquirement, produced with pathogenic bacteria, Causative virus microorganism and suppress or inactivate as index, and react the autologous drug of human body
In allowed limits, it can treat or auxiliary treatment includes but is not limited to rhinitis, sphagitis, pneumonia, pneumoconiosis, pulmonary tuberculosis；And make
For the serious city dweller's respiratory health purposes of air pollution.
4. pure chlorine dioxide solution according to claim 1 prepares the application of interior disinfectant, it is characterised in that：In described
It is used to be injected intravenously with disinfectant and uses, for chlorine dioxide concentration between 10~50mg/l, gas concentration lwevel is attached in 1.5g/l
Closely, the data obtained through animal experiment and human trial, produced with pathogenic bacteria, Causative virus microorganism and suppress or inactivate to refer to
Mark, and make human body autologous drug react in allowed limits, can treat or auxiliary treatment include but is not limited to AIDS virus,
Hepatitis viruse, Ebola virus, virus caused by leukaemia mainstay.
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| CN106138093A (en) * | 2015-04-15 | 2016-11-23 | 周伟文 | A kind for the treatment of clearing up pulmonary's dust and the auxiliary treating method of pulmonary infection |
| CN111904976A (en) * | 2020-04-17 | 2020-11-10 | 姚志勇 | Method for killing microorganism in vivo with iodine-containing preparation |
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| CN2463375Y (en) * | 2001-02-14 | 2001-12-05 | 深圳市保利马环保工程有限公司 | Carbon dioxide generator |
| CN101925358A (en) * | 2008-01-23 | 2010-12-22 | 大幸药品株式会社 | Chlorine dioxide liquid preparation composition |
| CN104586880A (en) * | 2014-09-17 | 2015-05-06 | 周伟文 | Preparation method of pure chlorine dioxide solution and method for treating Ebola virus infection |
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| EP1750502A4 (en) * | 2004-05-17 | 2011-09-07 | John Y Mason | Method of treating with chlorine dioxide |
| CN104083401B (en) * | 2007-02-16 | 2017-04-12 | 大幸药品株式会社 | Broad-spectrum antiviral composition with excellent preservation stabilty |
| CN101933938A (en) * | 2010-08-27 | 2011-01-05 | 王锡麟 | Sustained-release in-vivo pathogen killing agent and preparation and using methods thereof |
| CN102441006B (en) * | 2011-12-01 | 2016-06-01 | 刘学武 | A kind of hair-regrowth solution containing chlorine dioxide and preparation and application thereof |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN2463375Y (en) * | 2001-02-14 | 2001-12-05 | 深圳市保利马环保工程有限公司 | Carbon dioxide generator |
| CN101925358A (en) * | 2008-01-23 | 2010-12-22 | 大幸药品株式会社 | Chlorine dioxide liquid preparation composition |
| CN104586880A (en) * | 2014-09-17 | 2015-05-06 | 周伟文 | Preparation method of pure chlorine dioxide solution and method for treating Ebola virus infection |
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| CN115068500A (en) * | 2022-06-20 | 2022-09-20 | 张海杰 | Medicine for treating helicobacter pylori |
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