CN104644998A - Aerosol precursor containing medicinal compositions of snake gall and unibract fritillary bulb powder and method for dispersing aerosol precursor into nano-scale fog droplets - Google Patents
Aerosol precursor containing medicinal compositions of snake gall and unibract fritillary bulb powder and method for dispersing aerosol precursor into nano-scale fog droplets Download PDFInfo
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- CN104644998A CN104644998A CN201510100885.7A CN201510100885A CN104644998A CN 104644998 A CN104644998 A CN 104644998A CN 201510100885 A CN201510100885 A CN 201510100885A CN 104644998 A CN104644998 A CN 104644998A
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- fritillary
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Abstract
The invention relates to an aerosol precursor containing medicinal compositions of snake gall and unibract fritillary bulb powder. The aerosol precursor comprises the following components: glycerol, propylene glycol, 1,3-butanediol, aromatic substances and a snake gall and unibract fritillary bulb powder extract, wherein a mass proportion of glycerol to propylene glycol to 1,3-butanediol to the aromatic substances to the snake gall and unibract fritillary bulb powder extract is equal to (40-45):(20-25) :(0-10) :(0-10) :(1-10). The invention also relates to a method for dispersing the medicinal compositions in the snake gall and unibract fritillary bulb powder into nano-scale fog droplets, and also relates to an aerosol containing the nano-scale fog droplets. The aerosol precursor disclosed by the invention contains the medicinal compositions of the snake gall and unibract fritillary bulb powder, and the nano-scale fog droplets can be obtained by heating the aerosol precursor in an electronic cigarette smoking set which comprises an electric heating device so as to ensure that the aerosol precursor can be more beneficial for a human body to absorb the medicinal compositions.
Description
Technical field
The present invention relates to a kind of aerosol precursor, be specifically related to a kind of comprise shake bile-fritillary fall apart active ingredient aerosol precursor and be dispersed into the method for nanometer-sized mist droplets.
Background technology
The main component that shake bile-fritillary is loose is Fel Serpentis, Bulbus Fritillariae Cirrhosae.It is the light yellow powder to sundown; Sweet in the mouth, micro-hardship, have lung heat clearing, cough-relieving, effect of expectorant.Usually, the administering mode that shake bile-fritillary is loose is oral administration, and drug action is slow on the one hand for such administering mode; Medicine can be brought the zest of the intestines and stomach on the one hand; On the other hand, the first pass effect of liver can make utilization ratio of drug decline.
Aerosol be commonly referred to as when be heated or pressurized can produce the preparation of droplet.In medicinal pharmacology field, aerosol means the ejection in spray in use of pastille liquid, emulsion or suspension, sucks or be directly sprayed onto the preparation of tract mucosa, skin and space disinfection for pulmonary.Aerosol drug delivery has the following advantages: (1) medicine can directly arrive site of action or absorption site, has fairly obvious quick-acting roles and positioning effects, in respiratory tract administration, especially has the irreplaceable advantage of other dosage forms; (2) non-oral administration can reduce medicine to gastrointestinal zest, and can avoid the first pass effect of liver.
Usual inhalation aerosol should check droplet (grain) size distribution, and usual inhalation aerosol requires that its mean diameter should control below 10 μm, preferably below 5 μm.The method of the atomization of liquid has pressure atomization, rotary disk atomisation, gas atomization and sound wave atomization etc.It is micron-sized droplet that these atomizing types only can obtain mean diameter usually.
The representative patents of compound Chinese medicinal preparation being carried out to pressurizing atomizing is CN102949573A, the propellant of 80-100bar such as isceon, dichlorodifluoromethane or dichlorotetra-fluoroethane wherein will be used just to obtain micron order droplet to be atomized medicinal liquid, above-mentioned expulsion pressure is too high, holding tank air-tightness to propellant requires harsh, production cost is high, and propellant itself also cost is high.In addition, the mode of this pressurizing atomizing is along with the increase of drug use amount, and in tank, pressure constantly reduces, and medicinal atomized effect is also deteriorated gradually; Further, such tank for consumers only can single use, adds use cost.
Therefore, the diameter of droplet in the urgent need to a kind of method that can shake bile-fritillary be made to fall apart to be atomized into micron order droplet in atmospheric conditions, and preferably can be reduced further in this area, so that the degree of scatter improving medicinal liquid is further to improve absorption of human body efficiency.
Summary of the invention
The object of the present invention is to provide a kind of comprise shake bile-fritillary fall apart active ingredient aerosol precursor and be dispersed into the method for nanometer-sized mist droplets, user sucks and to fall apart the nanometer-sized mist droplets of active ingredient containing comprising shake bile-fritillary, more effectively can absorb medicinal ingredient wherein.
First aspect present invention relates to a kind of shake bile-fritillary that comprises and to fall apart the aerosol precursor of active ingredient, it comprises glycerol, propylene glycol, 1,3-butanediol, fragrance matter and shake bile-fritillary fall apart extractum, their mass ratio is glycerol: propylene glycol: 1,3 butylene glycol: fragrance matter: shake bile-fritillary falls apart extractum=(40-45): (20-25): (0-10): (0-10): (1-10).Wherein, the precursor of aerosol described in the present invention refer to when be heated or pressurized can produce droplet, during use can in the pastille liquid of spray, the general designation of emulsion or suspension etc.The loose shake bile-fritillary referring to required standard in " Chinese Pharmacopoeia " version in 2010 of the shake bile-fritillary related in the present invention falls apart, and namely prescription is Fel Serpentis 100g, Bulbus Fritillariae Cirrhosae 600g, and method for making is above two tastes, Bulbus Fritillariae Cirrhosae powder is broken into fine powder, mixes with Fel Serpentis, dry, pulverize, sieve, to obtain final product.Including within the scope of this invention with the shake bile-fritillary sold is loose of preparing of relevant criterion in good grounds " Chinese Pharmacopoeia ".
In application process, shake bile-fritillary part in active ingredient of faling apart can be dissolved in glycerol equal solvent; Part can with glycerol etc. for carrier, and be adsorbed on carrier surface by hydrogen bond action etc., the movement with carrier is transported to site of action.
Wherein said fragrance matter comprises conventional edible spice, such as 2,3-diacetyl, butyl phenylacetate, β-caryophyllene, dorinone etc.Preferably, described fragrance matter comprises nicotine, i.e. nicotine.
In preferred embodiments, the described shake bile-fritillary extractum that falls apart is obtained by the method comprised the following steps:
(1) remove impurity: be dissolved in food grade ethanol by loose for shake bile-fritillary, filter, remove insoluble impurity, obtain the alcoholic solution that shake bile-fritillary is loose;
(2) decolour: the alcoholic solution fallen apart by the shake bile-fritillary obtained in step (1) is by the first macroporous resin chromatography, and use ethanol-water solution eluting, removing pigment composition wherein, and utilize molecular distillation to remove desolventizing, obtain the first extractum;
(3) active ingredient extracts: with the first extractum obtained in acetic acid aqueous solution dissolving step (2), recycling organic solvent abstraction impurity removal from aqueous solution, retain water layer after layering, then utilize molecular distillation to dewater, obtain described shake bile-fritillary and to fall apart extractum; Wherein, described acetic acid aqueous solution is used for the main active substances alkaloids in extraction first extractum.
In preferred embodiments, in described step (2), the ethanol-water solution concentration range of eluting macroporous resin chromatography is 40-70 volume %; Independently, the organic solvent in described step (3) is selected from ethyl acetate, dichloromethane, chloroform, cyclohexane extraction or normal hexane.
In preferred embodiments, described step (2) Middle molecule distillation apparatus condition is: feed rate 0.8-1.0kgh
-1, feeding temperature 30-50 DEG C, vapo(u)rizing temperature 40-50 DEG C, the pressure 200-300Pa of distillation, scraper plate rotating speed 100-150rmin
-1.
In preferred embodiments, described step (3) Middle molecule distillation apparatus condition is: feed rate 0.5-1.0kgh
-1, feeding temperature 30-40 DEG C, vapo(u)rizing temperature 50-70 DEG C, the pressure 250-300Pa of distillation, scraper plate rotating speed 100-150rmin-1.
Second aspect present invention relate to a kind of shake bile-fritillary is fallen apart in active ingredient be dispersed into the method for nanometer-sized mist droplets, it to fall apart the aerosol precursor of active ingredient for the shake bile-fritillary that comprises heated in the electronic cigarette smoking set comprising electric heating device as described in the first aspect of the invention, make it be heated and be atomized into nanometer-sized mist droplets, be loaded with in this nanometer-sized mist droplets shake bile-fritillary fall apart in active ingredient.
In preferred embodiments, described electronic cigarette smoking set also has supersonic generator part, strengthens atomizing effect to apply supersonic oscillations to described aerosol precursor.
Third aspect present invention relates to a kind of aerosol comprising nanometer-sized mist droplets, and described nanometer-sized mist droplets comprises shake bile-fritillary and to fall apart active ingredient, and the particle size range of wherein said nanometer-sized mist droplets is 100-300nm.
Fourth aspect present invention relates to the aerosol that another kind comprises nanometer-sized mist droplets, described nanometer-sized mist droplets comprises shake bile-fritillary and to fall apart active ingredient, and it is by carrying out heating atomization by the fall apart aerosol precursor of active ingredient of shake bile-fritillary that comprises described in first aspect present invention and obtain.
Fifth aspect present invention relates to a kind of electronic cigarette tobacco tar, and it comprises the aerosol precursor described in first aspect present invention.Electronic cigarette tobacco tar of the present invention, compared to the electronic cigarette tobacco tar of routine, its sweet soapy feeling reduces greatly.
Beneficial effect of the present invention:
1, the shake bile-fritillary that comprises of the present invention falls apart the aerosol precursor of active ingredient by heating in the electronic cigarette smoking set comprising electric heating device, without the need to using the propellant of pressurization, just make it be heated to be atomized into the nanometer-sized mist droplets of the active ingredient be loaded with in CHUANBEI PIPA GAO, its particle size range is 100-300nm, and every mouthful of suction aerosol Particle density and size have concordance; Compared to common aerosol, after electronic cigarette atomizing, active ingredient can be atomized out along with flue gas, and particle diameter is nanoscale, not only specific surface area is larger, more easily absorbed by alveolar cell, and nanometer-sized mist droplets more easily enters into human respiratory tract, particularly Conventional aerosol is difficult to the lower respiratory tract depths of arrival, and is more conducive to absorption of human body active ingredient;
2, present invention utilizes the droplet carrier that electronic cigarette atomizing forms nanometer diameter, active ingredient is made to adhere to or be dissolved on droplet, then be drawn in human body through oral cavity, directly act on respiratory system, overcome shake bile-fritillary fall apart active ingredient oral after loss in digestion and blood circulation, improve shake bile-fritillary and to fall apart the effective rate of utilization of middle active ingredient;
3, the present invention can make the shake bile-fritillary middle active ingredient that falls apart be directly acted on by nano-carrier or be deposited on the oral cavity of human body, throat, upper respiratory tract and lower respiratory tract, shortens the action time of active ingredient in human body;
4, comprise shake bile-fritillary in electronic cigarette tobacco tar of the present invention to fall apart extractum by adding, the sweet soapy feeling of electronic cigarette tobacco tar itself can also be reduced, a kind of electronic cigarette tobacco tar with medical value and good suction impression is provided, smoking is become from being harmful to health and is good for one's health.
Detailed description of the invention
The invention is further illustrated by the following examples, should be appreciated that embodiment only in order to explain the present invention, the restriction not to technical solution of the present invention.
Embodiment 1
Comprise shake bile-fritillary to fall apart the aerosol precursor of active ingredient, it comprises glycerol, propylene glycol, 1,3 butylene glycol, fragrance matter and shake bile-fritillary and to fall apart extractum, and their mass ratio is glycerol: propylene glycol: shake bile-fritillary falls apart extractum=40:20:1.
The wherein said shake bile-fritillary extractum that falls apart is obtained by the method comprised the following steps:
(1) remove impurity: be dissolved in food grade ethanol by loose for shake bile-fritillary, filter, remove insoluble impurity, obtain the alcoholic solution that shake bile-fritillary is loose;
(2) decolour: the alcoholic solution fallen apart by the shake bile-fritillary obtained in step (1) is by the first macroporous resin chromatography, and be the ethanol-water solution eluting of 40 volume % by concentration, removing pigment composition wherein, and utilize molecular distillation to remove desolventizing, obtain the first extractum; The model of wherein said first macroporous resin chromatography is preferably MCIGEL CHP 20P (75-150 μm); Wherein molecular distillation instrument condition is: feed rate 0.8kgh
-1, feeding temperature 30 DEG C, vapo(u)rizing temperature 40 DEG C, the pressure 200Pa of distillation, scraper plate rotating speed 100rmin
-1;
(3) active ingredient extracts: with the first extractum obtained in acetic acid aqueous solution dissolving step (2), recycling ethyl acetate abstraction impurity removal from aqueous solution, retain water layer after layering, then utilize molecular distillation to dewater, obtain described shake bile-fritillary and to fall apart extractum; Wherein molecular distillation instrument condition is: feed rate 0.5kgh
-1, feeding temperature 30 DEG C, vapo(u)rizing temperature 50 DEG C, the pressure 250Pa of distillation, scraper plate rotating speed 100rmin
-1.
Above-mentioned the fall apart aerosol precursor of active ingredient of shake bile-fritillary that comprises is heated in the electronic cigarette smoking set comprising electric heating device and supersonic generator part, makes it be heated and be atomized into nanometer-sized mist droplets, be loaded with in this nanometer-sized mist droplets shake bile-fritillary fall apart in active ingredient.Be 201410380290.7 by number of patent application, the method of aerosol particle diameter is measured disclosed in title " a kind of method evaluating electronic cigarette amount of smoke ", record wherein be loaded with shake bile-fritillary fall apart in the particle size range of droplet of active ingredient be 100-300nm, compared with the mist droplet particle size of the 4-1000nm after being atomized with conventional electrical cigarette ree-oil distributes, mist droplet particle size distribution after aerosol precursor atomization of the present invention is more concentrated, and this may fall apart due to the shake bile-fritillary added and have the interaction of certain the unknown to cause between ree-oil.
As can be seen from embodiment 1, of the present invention be loaded with shake bile-fritillary fall apart in the mist droplet particle size scope of active ingredient be nanoscale, be more conducive to entering human respiratory tract depths and being absorbed by the body, there is good proper value.
Claims (10)
1. one kind comprises shake bile-fritillary and to fall apart the aerosol precursor of active ingredient, it is characterized in that, it comprises glycerol, propylene glycol, 1,3-butanediol, fragrance matter and shake bile-fritillary fall apart extractum, their mass ratio is glycerol: propylene glycol: 1,3 butylene glycol: fragrance matter: shake bile-fritillary falls apart extractum=(40-45): (20-25): (0-10): (0-10): (1-10).
2. aerosol precursor according to claim 1, is characterized in that, the described shake bile-fritillary extractum that falls apart is obtained by the method comprised the following steps:
(1) remove impurity: be dissolved in food grade ethanol by loose for shake bile-fritillary, filter, remove insoluble impurity, obtain the alcoholic solution that shake bile-fritillary is loose;
(2) decolour: the alcoholic solution fallen apart by the shake bile-fritillary obtained in step (1) is by the first macroporous resin chromatography, and use ethanol-water solution eluting, removing pigment composition wherein, and utilize molecular distillation to remove desolventizing, obtain the first extractum;
(3) active ingredient extracts: with the first extractum obtained in acetic acid aqueous solution dissolving step (2), recycling organic solvent abstraction impurity removal from aqueous solution, retain water layer after layering, then utilize molecular distillation to dewater, obtain described shake bile-fritillary and to fall apart extractum.
3. aerosol precursor according to claim 2, is characterized in that, in described step (2), the ethanol-water solution concentration range of eluting macroporous resin chromatography is 40-70 volume %; Independently, the organic solvent in described step (3) is selected from ethyl acetate, dichloromethane, chloroform, cyclohexane extraction or normal hexane.
4. aerosol precursor according to claim 2, is characterized in that, described step (2) Middle molecule distillation apparatus condition is: feed rate 0.8-1.0kgh
-1, feeding temperature 30-50 DEG C, vapo(u)rizing temperature 40-50 DEG C, the pressure 200-300Pa of distillation, scraper plate rotating speed 100-150rmin
-1.
5. aerosol precursor according to claim 2, is characterized in that, described step (3) Middle molecule distillation apparatus condition is: feed rate 0.5-1.0kgh
-1, feeding temperature 30-40 DEG C, vapo(u)rizing temperature 50-70 DEG C, the pressure 250-300Pa of distillation, scraper plate rotating speed 100-150rmin
-1.
6. one kind shake bile-fritillary is fallen apart in active ingredient be dispersed into the method for nanometer-sized mist droplets, it is characterized in that, in the electronic cigarette smoking set comprising electric heating device, the comprise shake bile-fritillary of heating according to any one of claim 1-5 falls apart the aerosol precursor of active ingredient, make it be heated and be atomized into nanometer-sized mist droplets, be loaded with in this nanometer-sized mist droplets shake bile-fritillary fall apart in active ingredient.
7. method according to claim 6, is characterized in that, described electronic cigarette smoking set also has supersonic generator part.
8. comprise an aerosol for nanometer-sized mist droplets, described nanometer-sized mist droplets comprises shake bile-fritillary and to fall apart active ingredient, and it is characterized in that, the particle size range of wherein said nanometer-sized mist droplets is 100-300nm.
9. one kind comprises the aerosol of nanometer-sized mist droplets, described nanometer-sized mist droplets comprises shake bile-fritillary and to fall apart active ingredient, it is characterized in that, it is by carrying out heating atomization by the fall apart aerosol precursor of active ingredient of shake bile-fritillary that comprises according to any one of claim 1-5 and obtain.
10. an electronic cigarette tobacco tar, is characterized in that, it comprises the aerosol precursor according to any one of claim 1-5.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510100885.7A CN104644998A (en) | 2015-03-06 | 2015-03-06 | Aerosol precursor containing medicinal compositions of snake gall and unibract fritillary bulb powder and method for dispersing aerosol precursor into nano-scale fog droplets |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510100885.7A CN104644998A (en) | 2015-03-06 | 2015-03-06 | Aerosol precursor containing medicinal compositions of snake gall and unibract fritillary bulb powder and method for dispersing aerosol precursor into nano-scale fog droplets |
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| CN104644998A true CN104644998A (en) | 2015-05-27 |
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| CN201510100885.7A Pending CN104644998A (en) | 2015-03-06 | 2015-03-06 | Aerosol precursor containing medicinal compositions of snake gall and unibract fritillary bulb powder and method for dispersing aerosol precursor into nano-scale fog droplets |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110916241A (en) * | 2019-11-20 | 2020-03-27 | 许达勇 | Nicotine aerosol and preparation method thereof |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2014125340A1 (en) * | 2013-02-15 | 2014-08-21 | Pharmaday S.R.L. | Smoke liquid for atomizers and/or vaporizers |
| CN104122179A (en) * | 2014-08-05 | 2014-10-29 | 云南中烟工业有限责任公司 | Method for evaluating smoke volume of electronic cigarettes |
-
2015
- 2015-03-06 CN CN201510100885.7A patent/CN104644998A/en active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2014125340A1 (en) * | 2013-02-15 | 2014-08-21 | Pharmaday S.R.L. | Smoke liquid for atomizers and/or vaporizers |
| CN104122179A (en) * | 2014-08-05 | 2014-10-29 | 云南中烟工业有限责任公司 | Method for evaluating smoke volume of electronic cigarettes |
Non-Patent Citations (1)
| Title |
|---|
| 杨雄志: "《中医药基础》", 31 January 2012, 河南科学技术出版社 * |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110916241A (en) * | 2019-11-20 | 2020-03-27 | 许达勇 | Nicotine aerosol and preparation method thereof |
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