CN104644997A - Medicine for treating lobular hyperplasia of mammary glands - Google Patents

Abstract

The invention relates to the field of medicine formulas, and in particular relates to a medicine for treating lobular hyperplasia of mammary glands. The medicine is technically characterized by being prepared from the following raw material medicines in percentage by weight: 4-6% of Chinese thorowax root, 13-15% of red paeony root, 13-15% of white paeony root, 8-10% of largehead atractylodes rhizome, 4-6% of Indian buead, 2-4% of pinellia tuber, 3-5% of green tangerine peel, 4-6% of Chinese angelica, 4-6% of safflower, 3-5% of bulb of thunberg fritillary, 4-6% of snakegourd fruit, 3-5% of towel gourd vegetable sponge, 3-5% of cowherb seed and 13-15% of raw oyster shell. A preparation method comprises the following steps: soaking the raw material medicines into water, decocting, and then removing residues to obtain a filtrate. The medicine disclosed by the invention is low in cost, has high curative effects on treatment of lobular hyperplasia of mammary glands, cannot cause toxic or side effects, has the functions of discharging the liver and relieving depression, invigorating the spleen and reducing phlegm, promoting qi circulation and dredging collaterals, activating blood and nourishing blood, softening hardness and dissipating stagnation, enhancing the body immunity, balancing the internal secretion and eliminating the hyperplastic tissues, and is suitable for treating various types of lobular hyperplasia of mammary glands.

Description

For the medicine of cyclomastopathy

Technical field

The present invention relates to a kind of Chinese patent medicine preparation, specifically a kind of medicine for cyclomastopathy.

Background technology

As everyone knows, cyclomastopathy is mainly the hyperplasia of prostate of mammary gland interstitial, and hypertrophy can to betide around glandular tube and to be formed with the cyst differed in size; Also the nipple sample hypertrophy showing as epithelium in glandular tube can be occurred in, the cystic dilatation of companion's latex dust.In addition, a kind of type of lobule essence hypertrophy is still had.The pathogenic factor of cyclomastopathy and pathogeny relevant with endocrine disturbance and Nervous and Mental Factors, the psychoneural factor etc. that the external environment condition of people living, work and living condition, inter personal contact, various pressure cause all can make the environment of human body change, thus affect the function of hormonal system, and then it is abnormal to make the secretion of a certain or several hormone occur, lutein secretion reduces, it is the major reason that cyclomastopathy is fallen ill that estrogen increases relatively, causes cyclomastopathy.In modern mammary gland therapeutic, although both at home and abroad medical personnel did the research of multiple method for many years in this field, Therapeutic Method and medicine varied, do not reach gratifying degree yet, still have an a lot of difficult problem not yet to solve.As 1, effect a radical cure problem completely: treatment at present upper basic be symptomatic treatment, the tissue of hypertrophy can only be made to reduce, but can not disappear completely, cyclomastopathy can recur, and can not effect a radical cure completely.2, immune problem: the immunity how improving body, not by the invasion and attack of virulence factor, is the difficult problem of pendulum in face of every medical personnel.3, endocrine adjustment: the many factors such as nerve, immunity and trace element all can cause the unbalance of the various endocrine hormone of body.How making incretion balance, make various hormonal readiness if lutein and estrogen are within normal range, and play it and normally act on, is also the problem needing us to solve.To this, we are through scientific appraisal, screening, test, have invented bavin Chinese herbaceous peony beach wormwood shellfish and to have disappeared addiction soup, be used for the treatment of various cyclomastopathy.

Summary of the invention

Technical problem to be solved by this invention is to overcome the deficiencies in the prior art, there is provided a kind of cost low, treatment cyclomastopathy curative effect is high, without irritated, and non-toxic reaction, have no side effect, and can allergy be prevented, have and improve blood circulation of breast, blood vessel dilating, increase latex dust elasticity, make that breast tissue blood flow is unimpeded, eliminate pain; Immunity moderation, nerve, endocrine function, make ovarian function normalization simultaneously, thus make lutein and oestrogen balance secretion, solves the effects such as cyclomastopathy basic reason, to all effective medicine of cyclomastopathy that a variety of causes causes.

The technical scheme that the present invention solves the problems of the technologies described above employing is: a kind of medicine for cyclomastopathy, its technical characteristic is, be made up of the crude drug of following percentage by weight: Radix Bupleuri 4 ~ 6%, Radix Paeoniae Rubra 13 ~ 15%, the Radix Paeoniae Alba 13 ~ 15%, the Rhizoma Atractylodis Macrocephalae 8 ~ 10%, Poria 4 ~ 6%, the Rhizoma Pinelliae 2 ~ 4%, Pericarpium Citri Reticulatae Viride 3 ~ 5%, Radix Angelicae Sinensis 4 ~ 6%, Flos Carthami 4 ~ 6%, Bulbus Fritillariae Thunbergii 3 ~ 5%, Fructus Trichosanthis 4 ~ 6%, Retinervus Luffae Fructus 3 ~ 5%, Semen Vaccariae 3 ~ 5%, Concha Ostreae 13 ~ 15%, by medicinal for above-mentioned raw materials water soaking, filtrate of removing slag after decocting to obtain.

The invention has the beneficial effects as follows, cost is low, and treatment cyclomastopathy curative effect is high, have no side effect, there is dispersing the stagnated live-QI to relieve the stagnation of QI, key spleen reduces phlegm, promoting of the circulation of QI and removing the obstruction in the collaterals, nourishing blood and promoting blood circulation, hard masses softening and resolving, improve immunity of organisms, balance endocrine, makes the functions such as the tissue disappearance of hypertrophy.Be applicable to treat various types of cyclomastopathy.

Detailed description of the invention

Below in conjunction with embodiment, the invention will be further described:

Embodiment 1:

Radix Bupleuri, Radix Paeoniae Rubra, the Radix Paeoniae Alba, the Rhizoma Atractylodis Macrocephalae, Poria, the Rhizoma Pinelliae, Pericarpium Citri Reticulatae Viride, Radix Angelicae Sinensis, Flos Carthami, Bulbus Fritillariae Thunbergii, Fructus Trichosanthis, Retinervus Luffae Fructus, Semen Vaccariae, Concha Ostreae is adopted to be that raw material is prepared from.Its component (% by weight) is often paid as Radix Bupleuri 5, Radix Paeoniae Rubra 14, the Radix Paeoniae Alba 14, the Rhizoma Atractylodis Macrocephalae 10, Poria 5, the Rhizoma Pinelliae 3, Pericarpium Citri Reticulatae Viride 5, Radix Angelicae Sinensis 5, Flos Carthami 5, Bulbus Fritillariae Thunbergii 5, Fructus Trichosanthis 5, Retinervus Luffae Fructus 4, Semen Vaccariae 5, Concha Ostreae 15.Get above-mentioned 14 taste raw material gross weight 212 grams, at room temperature above-mentioned 14 taste Chinese herbal medicine are cut into slices or section, add water to 900 ~ 1100ml, soak 4 hours, then boil slow fire with high heat and decoct 60 ~ 80 minutes, remove slag to obtain filtrate about 300ml, medicinal residues add water 300ml again, decoct 30 minutes, remove slag to obtain filtrate about 100ml, is total to obtain about 400ml, treat slightly cold after, to dry in the air cool filtration, get filtrate autoclave sterilization, be i.e. obtained decoction of the present invention.Be equipped with in scale sterile glass vials, seal bottle cap is for subsequent use.During use, every day potion, point secondary is oral, each (medicine) being taken before meal 200ml, and premenstrual 7 days start to take medicine at every turn, and menstrual period withdraw, through after continue to take, and keep happy.

Principal agent Radix Bupleuri of the present invention has calmness, analgesia, has and removes distending pain uncomfortable in chest, dissipating depression of QI regulating menoxenia; And having Promote immunity function, phagocytic function strengthens, Natural killer activity strengthens.Improve special viral antibody titre, improve lymphocyte and turn core rate.Improve skin delayed hypersensitivity reaction.Radix Bupleuri nature and flavor hardship is flat, enters liver, gallbladder meridian.Function is brought down a fever for inducing sweat, dispersing the stagnated live-QI to relieve the stagnation of QI, elevate a turnable ladder yang-energy.Cure mainly fever caused by exogenous pathogens; Alternate attack of chill and fever; Malaria; Hypochondriac pain due to stagnation of liverQI mammary swelling; Headache dizziness; Menoxenia; The proctoptosis of collapse of QI; Uterine prolapse; Gastroptosis.Radix Paeoniae Rubra nature and flavor are bitter, are slightly cold, return liver, spleen channel.There is clots absorbing, pain relieving, removing heat from blood, detumescence, clearing away heat and cooling blood, the function of eliminating stasis to stop pain.For maculae caused by violent heat pathogen, hematemesis and epistaxis, conjunctival congestion and swelling pain, hypochondriac pain due to stagnation of liverQI, amenorrhea dysmenorrhea, lump in the abdomen is suffered from abdominal pain, injury from falling down, carbuncle skin infection.Radix Paeoniae Alba experiment shows all have potentiation to cellular immunization and humoral immunization, the Radix Paeoniae Alba in vivo with the external equal phagocytic function that can promote macrophage, the antibacterial action of the Radix Paeoniae Alba is comparatively strong, and antimicrobial spectrum is wider.Inhibitory action is in various degree had in vitro to staphylococcus aureus, Hemolytic streptococcus, Streptococcus viridans, streptococcus pneumoniae, Bacillus typhi, Bacillus paratyphosus B, dysentery bacterium, escherichia coli, bacillus pyocyaneus, Bacillus proteus, bordetella pertussis, vibrio cholera etc.Radix Paeoniae Alba nature and flavor are bitter, sour; Be slightly cold.Return liver; Spleen channel.Have nourish blood and seek, relieving spasm to stop pain, yin fluid astringing suppressing the hyperactive liver function.Main menoxenia; Abdominal pain during menstruation; Metrorrhagia; Spontaneous perspiration; Night sweat; Side of body rib epigastric pain; Limb pain twin; Headache; Dizzy.Rhizoma Atractylodis Macrocephalae bitter in the mouth, sweet; Warm in nature.Return spleen, stomach warp.Function is invigorating the spleen and benefiting QI; Dampness diuretic; Hidroschesis; Antiabortive.Main deficiency-weakness of spleen-QI; Spiritlessness and weakness; Lack of appetite abdominal distention; Large loose stool is thin; Fluid-retention stagnating in the interior; Dysuria; Edema; Dizziness due to fluid-retention; Arthralgia chiefly caused by damp pathogen is ached; Spontaneous sweating due to deficiency of QI; Frequent fetal movement.Poria has diuresis and improves humoral immune function.Nature and flavor are sweet, light, flat.GUIXIN, spleen, kidney channel.Function is promoting diuresis to eliminate damp pathogen, and spleen invigorating, calms the nerves.Cure mainly edema oliguria, phlegm retention vertigo and palpitation, insufficiency of the spleen lack of appetite, have loose bowels in loose stool, irritability, palpitation with fear insomnia.Rhizoma Pinelliae acrid in the mouth, warm in nature; Poisonous.Return spleen, stomach, lung meridian.Function is drying dampness to eliminate phlegm; Stopping nausea and vomiting by lowering the adverse flow of QI; Dissolving lump and resolving mass.Main cough with asthma abundant expectoration; Vomiting regurgitation; Feeling of oppression and fullness in the chest and epigastrium headache is dizzy; Uneasy sleeping at night; Gall subcutaneous nodule; Swollen ulcer drug.Pericarpium Citri Reticulatae Viride nature and flavor are bitter, pungent; Temperature.Return liver, gallbladder, spleen, lung, heart channel.Function is soothing the liver dispelling the stagnated QI; Removing food stagnancyization is stagnant.The distending pain over the hypochondrium of main stagnation of QI due to depression of the liver; Distending pain of the breast; Nodule in the breast; Acute mastitis; Hernia pain; The epigastric distending pain of stagnation of QI due to dyspepsia; And qi depression to blood stasis institute is Zhi lumps in the chest and abdomen; Chronic malaria addiction block.Radix Angelicae Sinensis sweet in the mouth; Temperature.Return liver, the heart, spleen channel.Function is for enriching blood, invigorating blood circulation; Menstruction regulating and pain relieving; Moisturize laxation.The all cards of main blood deficiency; Menoxenia; Amenorrhea; Dysmenorrhea; Mass in the abdomen knot is poly-; Metrorrhagia; Asthenia cold abdominalgia; Flaccidity syndrome and arthralgia syndrome; Numbness of the skin; Dryness of the intestine dyschezia; Heavy after bloody dysentery; Ulcer sores; Injury from falling down.Flos Carthami acrid in the mouth; Warm in nature.GUIXIN, Liver Channel.Function is promoting blood circulation to restore menstrual flow; Stasis-dispelling and pain-killing.Main warp closes; Dysmenorrhea; Postpartum stagnation is suffered from abdominal pain; Traumatic injury; Arthralgia; Apoplexy is attached undue importance to one thing to the neglect of the other; Macule.Bulbus Fritillariae Thunbergii bitter in the mouth; Cold in nature.Return lung, heart channel.Function is removing heat-phlegm; Sending down the abnormal ascending QI cough-relieving; Mass dissipating and swelling eliminating.Main air heat or phlegm-heat cough; Lung abscess vomiting pus; Scrofula goiter; Sore and toxic.Sweet, the micro-hardship of Fructus Trichosanthis, cold.Return lung, stomach, large intestine channel.Function is clearing away heat and eliminating phlegm, and relieving stuffiness of the chest by dispersing aggregation of pathogens, moisturizes laxation.For cough due to lung-heat, the turbid Huang of expectorant is thick, obstruction of qi in the chest and cardialgia, blocked-up chest feeling of fullness, acute mastitis, lung abscess, and acute appendicitis swells and ache, constipation.Retinervus Luffae Fructus bitter in the mouth; Cool in nature; Return lung, liver, stomach warp.Function is dredge the meridian passage; Removing toxic substances and promoting subsidence of swelling.Main pain in chest and hypochondrium; Rheumatic arthralgia, passages through which vital energy circulates contracture, galactostasis, cough due to lung-heat, carbuncle sore tumefacting virus, acute mastitis.Semen Vaccariae bitter in the mouth, property is put down; Return liver, stomach warp; Enter blood system, walk and do not keep; There is promoting blood circulation to restore menstrual flow, stimulating milk secretion eliminating carbuncle, inducing diuresis for treating stranguria syndrome; Cure mainly dysmenorrhea due to blood stasis, amenorrhea, galactostasis, acute mastitis skin ulcer swells, stranguria, dysuria.Concha Ostreae has convergence, calmness, removing toxic substances, analgesic effect.Salty in the mouth; Cold nature.Return liver; Kidney channel.Function is promoting blood circulation to restore menstrual flow; Stimulating milk secretion eliminating carbuncle.Housewife female's abdominal pain during menstruation; Amenorrhea; Galactostasis; Acute mastitis; Carbuncle.The ingenious prescription of 14 taste Chinese herbal medicine, the mutual coordinative role of medicine, plays the specially good effect for the treatment of cyclomastopathy altogether.

The each raw material of the present invention also can the embodiment that mixes of ratio (percentage by weight) listed by according to the form below realize.

Its processing technique is identical with embodiment 1.

Below in conjunction with my institute, the clinical experiment that namely central hospital of In Shandong Weihai Wendeng City carries out is further described the present invention:

1, case selection: selected case is the cyclomastopathy that a variety of causes causes, this group collects 156 routine cyclomastopathy patients altogether, all through mammary gland color ultrasound examination be cyclomastopathy, the course of disease 1 ~ 5 year.

2, diagnostic criteria and the standard of curative effect evaluation: diagnostic criteria is with reference to the diagnostic criteria of newly organized " surgery ".Effect evaluation criterion: according to breast disease special commission of surgery branch of Chinese association of traditional Chinese medicine standard.Effective: lump disappears, mastalgia disappears, drug withdrawal nothing recurrence in 3 months; Effective: lump in breast maximum gauge reduces more than 1/2, and mastalgia alleviates; Invalid: lump in breast is without reducing, and mastalgia takes a turn for the better but has recurrence.Effective adding is effectively patient's effective percentage.

3, Therapeutic Method: every day potion, point secondary is oral, each (medicine) being taken before meal about 200ml, and premenstrual 7 days start to take medicine at every turn, and menstrual period withdraw, through after continue clothes, and keep happy, treatment three months altogether.

4, therapeutic effect: the 156 routine cyclomastopathy patients using the present invention's treatment, application the standard of curative effect evaluation carries out treatment effectiveness evaluation, and effective 92 examples, account for 58.97%, effective 53 examples, account for 33.97%, invalid 11 examples, account for 7.05%, always effective 145 examples, account for 92.95%.

Result shows: decoction of the present invention, and oral administration acts on mammary gland tissue, improves blood circulation of breast, blood vessel dilating, increases latex dust elasticity.Make that breast tissue blood flow is unimpeded, eliminate pain simultaneously.Further adjustment hypothalamic-pituitary-ovarian function, immunity moderation, nerve, endocrine function, make ovarian function normalization on the one hand, thus make lutein and oestrogen balance secretion, solves cyclomastopathy basic reason.The cystic hyperplasia of breast such as cyclomastopathy, mastitis, mammary gland fibroma is adopted without pain, the most rapidly, approach the most thoroughly, light cure diseases.

Model case

1, patient Wang, female, 36 years old, marriedly to educate, office worker.In JIUYUE in 2011 first visit on the 3rd.Bilateral mastalgia 2 years, before passing through and angry after pain more so.The two newborn outside upper quadrant of palpation all can touch flat lump, and right side is 2.6cm × 2.4cm about, and left side is 3.5cm × 3.2cm about, matter is tough, smooth, movable, tenderness is obvious, is diagnosed as cyclomastopathy, treats 3 months through ultrasound diagnosis, mammary gland pain and lump disappear completely, with examining half a year without recurrence.

2, patient blue certain, female, 43 years old, marriedly to educate, workman.In first visit on March 28 in 2012.Bilateral mastalgia 1 year, increases the weight of 1 year, and before passing through, pain more so.The outside upper quadrant of the right breast of palpation, the outside upper quadrant of left breast and UIQ all can touch flat lump, right side about 1.8cm × 2.5cm, left side about 3.2cm × 3.6cm, matter is tough, smooth, movable, tenderness is obvious, be diagnosed as cyclomastopathy through ultrasound diagnosis, premenstrual 7 days start to take medicine at every turn, and menstrual period withdraw, through after continue clothes, and keep happy.After 3 months, mammary gland pain and lump disappear completely, with examining 1 year without recurrence.

3, patient bent certain, female, 45 years old, marriedly to educate, teacher.In first visit on August 16 in 2013.Bilateral mastalgia 3 years, before passing through and angry after pain increase the weight of.The outside upper quadrant of the right breast of palpation and UIQ, the outside upper quadrant of left breast all can touch flat lump, matter is tough, smooth, movable, tenderness is obvious, right side about 2.5cm × 3.5cm is checked through breast molybdenum target x-ray, left side about 2.3cm × 2.7cm size hypertrophy, treat 3 months, mammary gland pain and lump disappear completely, with examining half a year without recurrence.

Claims (1)

1. the medicine for cyclomastopathy, its technical characteristic is, be made up of the crude drug of following percentage by weight: Radix Bupleuri 4 ~ 6%, Radix Paeoniae Rubra 13 ~ 15%, the Radix Paeoniae Alba 13 ~ 15%, the Rhizoma Atractylodis Macrocephalae 8 ~ 10%, Poria 4 ~ 6%, the Rhizoma Pinelliae 2 ~ 4%, Pericarpium Citri Reticulatae Viride 3 ~ 5%, Radix Angelicae Sinensis 4 ~ 6%, Flos Carthami 4 ~ 6%, Bulbus Fritillariae Thunbergii 3 ~ 5%, Fructus Trichosanthis 4 ~ 6%, Retinervus Luffae Fructus 3 ~ 5%, Semen Vaccariae 3 ~ 5%, Concha Ostreae 13 ~ 15%, by medicinal for above-mentioned raw materials water soaking, filtrate of removing slag after decocting to obtain.