CN104644745B - A kind of habitat processing method of radix scutellariae and application - Google Patents
A kind of habitat processing method of radix scutellariae and application Download PDFInfo
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- CN104644745B CN104644745B CN201510086347.7A CN201510086347A CN104644745B CN 104644745 B CN104644745 B CN 104644745B CN 201510086347 A CN201510086347 A CN 201510086347A CN 104644745 B CN104644745 B CN 104644745B
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Abstract
The present invention relates to a kind of habitat processing method of radix scutellariae and applications.The described method includes: (1) rams time: cadmium yellow a kind of reed mentioned in ancient books of harvesting being dried, then knocks the cork on its surface；(2) two times are hit: step (1) treated radix scutellariae is dried, is then hit to the radix scutellariae in yellowish-brown, i.e. Munsell colour system chromatic value is 5Y6/ (6~8) or 7.5YR5/ (4~8)；(3) three times are hit: step (2) treated radix scutellariae is dried, is then hit to the radix scutellariae in golden yellow, i.e. 5Y8/ (8~12), 2.5Y7/ (8~10), 2.5Y8/10 or 5Y7/8；(4) four times are hit: step (3) treated radix scutellariae is dried, is then hit to the radix scutellariae in yellow-white, i.e. 5Y8/ (4~6) or 2.5Y8/ (4~8).The present invention also provides application of the method in terms of medicinal material Habitat producing.Method of the invention can significantly improve the content of the main effective component scutelloside of radix scutellariae medicinal materials, baicalein and wogonoside, form preferable Medicinal Materials Characters, improve medicinal material commodity specification grade, and be easy to medicinal material classification.
Description
Technical field
The present invention relates to Chinese medicine manufacture fields, and in particular to Chinese medicine Habitat producing technical field, more particularly to it is a kind of
The habitat processing method of radix scutellariae and application.
Background technique
Radix scutellariae (Scutellaria baicalensis Georgi) is Lamiaceae plant, is used as medicine with root.There is heat-clearing and damp-drying drug,
The effect of cool blood miscarriage prevention and removing toxic substances.Cure mainly warm heat disease, the infection of the upper respiratory tract, cough with lung heat, neonatal jaundice caused by dampness-heat, pneumonia, dysentery, cough
The diseases such as blood, hot eyes, threatened abortion, hypertension and carbuncle swells furuncle sore.Radix scutellariae mainly originate in Hebei, Liaoning, Shaanxi, Shandong, the Inner Mongol,
The ground such as Heilungkiang, wherein the produced radix scutellariae curative effect in Chengde area is best, since ancient times titled with the good reputation of " hot river radix scutellariae ".
Existing radix scutellariae processing technology is mostly spring and autumn excavation, and simple remove is shone after fibrous root and silt to half-dried, then
It is bundled into wisp or ricks and dry or dry, radix scutellariae medicinal materials are made.More, the length according to radix scutellariae medicinal materials bifurcated made of the prior art
Mix with thickness, the non-medicinal effects such as crust and impurity are more, and whole medicinal material specification grade is low, and is unfavorable for sizing screening, medicine
Material amount not can guarantee yet.Therefore, a kind of radix scutellariae medicinal materials quality and the habitat processing method of standardization of capable of improving is that we pay close attention to
Emphasis.
Summary of the invention
The purpose of the present invention is to provide a kind of radix scutellariae habitat processing methods that can improve radix scutellariae medicinal materials quality and specification.
To achieve the above objectives, the invention adopts the following technical scheme:
In a first aspect, the present invention provides a kind of habitat processing method of radix scutellariae, it is described to hit suitcase the method includes hitting skin
It includes:
(1) it rams time: cadmium yellow a kind of reed mentioned in ancient books of harvesting being dried, then knocks the cork on its surface；
(2) two times are hit: step (1) treated radix scutellariae is dried, is then hit to the color of the radix scutellariae in yellowish-brown, i.e.,
Munsell colour system chromatic value is 5Y6/ (6~8) or 7.5YR5/ (4~8), such as can be 5Y6/8,5Y6/6,7.5YR5/
8,7.5YR5/6 or 7.5YR5/4；
(3) three times are hit: step (2) treated radix scutellariae is dried, is then hit to the color of the radix scutellariae in golden yellow, i.e.,
Munsell colour system chromatic value is 5Y8/ (8~12), 2.5Y7/ (8~10), 2.5Y8/10 or 5Y7/8, such as be can be
5Y8/12,5Y8/10,5Y8/8,5Y7/8,2.5Y8/10,2.5Y7/10 or 2.5Y7/8；
(4) four times are hit: step (3) treated radix scutellariae is dried, is then hit to the color of the radix scutellariae in yellow-white, i.e.,
Munsell colour system chromatic value be 5Y8/ (4~6) or 2.5Y8/ (4~8), such as can be 5Y8/6,5Y8/4,2.5Y8/8,
2.5Y8/6 or 2.5Y8/4.
Munsell colour system used in the present invention (Munsell Color System) is a kind of extensive in the world at present
The three-dimensional model color representation of application, the color system are also the side of international field of Chinese medicines classification and calibration surface colour
Method.It is the spheroidal spatial model of three-dimensional, three kinds of essential attributes --- the form and aspect, lightness of the various surface colours of object
It all shows with chroma, color classification and calibration system is formulated with the visual characteristic of color, to press visual color perception
Equally spaced mode comes out the character representation of various surface colours.Munsell hue indicates 10 kinds of bases with colour solid horizontal profile
This color, contains 5 kinds of primary colors: red (R), yellow (Y), green (G), blue (B), purple (P) and 5 kinds of secondary colors: Huang Hong (YR), greenish-yellow (GY),
Bluish-green (BG), purplish blue (PB), purple (RP)；40 kinds of colors are sub-divided on the basis of above-mentioned 10 kinds main colors；Munsell is bright
Angle value is 0~10, is divided into 11 visually equidistant grades, it would be desirable to which white is set to 10, and perfect black is set to 0；Meng Sai
Your chroma represents the variation of saturation degree for the horizontal distance that sample of colour leaves the axis of centres, and the muted color chroma on the axis of centres is 0,
It is remoter to leave the axis of centres, chroma value is bigger.Any color can be this three with form and aspect, brightness value and the chroma in colour solid
Coordinate is demarcated, and the method for calibration is first to write out form and aspect H, then write angle value V exactly, chroma C is write after oblique line；Such as in claim
Step (2) is hit two times in 1, and filemot Munsell colour system chromatic value is 5Y6/ (6~8), i.e., form and aspect are yellow 5, lightness
It is 6, chroma is 6~8.
Preferably, step (1) sunning be that dry to the water content of radix scutellariae be 50~95%, such as can be 50%,
55%, 60%, 65%, 70%, 75%, 80%, 85%, 90% or 95%；Preferably 60~80%, more preferably 70~
80%；
Preferably, step (1) is described knocks the cork on its surface to knock the cork on its surface 80~100%, example
Such as can be 80%, 81%, 82%, 83%, 84%, 85%, 86%, 87%, 88%, 89%, 90%, 91%, 92%,
93%, 94%, 95%, 96%, 97%, 98%, 99% or 100%；Cork, that is, dark brown Lao Pi；
Ram all over when, the water content of radix scutellariae is relatively high, thus mainly hit the impurity such as exocuticle and soil, if radix scutellariae
Moisture content it is excessively high, easily snap off radix scutellariae, therefore select the water content ranges, the exocuticle of radix scutellariae, which has been dried, at this time opens
It splits, tilt, be easy to hit Lao Pi.
Preferably, step (2) sunning be that dry to the water content of radix scutellariae be 35~60%, such as can be 35%,
38%, 40%, 43%, 45%, 48%, 50%, 53%, 55%, 57% or 60%；Preferably 40~60%, more preferably 40
~50%；
Preferably, step (2) is advisable with being not easily broken when breaking radix scutellariae curvature no more than 30 degree with hand, is then hit to described
The Lao Pi on radix scutellariae surface is completely fallen off, and the color of radix scutellariae is in yellowish-brown, preferably Munsell colour system chromatic value 5Y6/8,
5Y6/6,7.5YR5/8,7.5YR5/6 or 7.5YR5/4.
This stage radix scutellariae is half dried food and nuts, and toughness is moderate, mainly hits exocuticle and other impurities that decaptitating time does not remove；
If hitting skin too early, since the moisture content of radix scutellariae is high, it is not easy that head time is not hit net Lao Pi and hit to lose；If it is too late hit Pi Zehui because
Moisture content is low and frangibility, reduces shipment rate.
Preferably, step (3) sunning be that dry to the water content of radix scutellariae be 20~40%, such as can be 20%,
21%, 22%, 23%, 24%, 25%, 26%, 27%, 28%, 29%, 30%, 31%, 32%, 33%, 34%, 35%,
36%, 37%, 38%, 39% or 40%, preferably 20~30%；
Preferably, step (3) is hard with feel, and microbend frangibility is advisable；Then it hits to the color of the radix scutellariae in gold
Yellow, preferably Munsell colour system chromatic value 5Y8/12,5Y8/10,5Y8/8,5Y7/8,2.5Y8/10,2.5Y7/10 or
2.5Y7/8。
This stage moisture content is substantially reduced, and has almost been hit only by the preceding skin exocuticle that hits twice, radix scutellariae original color yellow
Obviously.
Preferably, step (4) sunning be that dry to the water content of radix scutellariae be 0~10%, for example, can be 0,1%,
2%, 3%, 4%, 5%, 6%, 7%, 8%, 9% or 10%；
Preferably, step (4) hits the radix scutellariae after sunning to yellow-white, with micro- " undisguised " (a kind of reed mentioned in ancient books body is smooth, like sclerotin sample)
" hanging powder " (there be a layer yellow fine powder in outer surface) is advisable, preferably Munsell colour system chromatic value 5Y8/6,5Y8/4,2.5Y8/
8,2.5Y8/6 or 2.5Y8/4.
It hits four times primarily to forming Medicinal Materials Characters characteristic to powder on radix scutellariae.
Preferably, described to hit skin use and hit skin machine；The power for hitting skin machine is 1.0~2.0kW, such as be can be
1.0kW, 1.1kW, 1.2kW, 1.3kW, 1.4kW, 1.5kW, 1.6kW, 1.7kW, 1.8kW, 1.9kW or 2.0kW；Preferably
1.5kW or 2.0kW；
Preferably, the working speed for hitting skin machine be 800~1200rpm, such as can be 800rpm, 850rpm,
900rpm, 950rpm, 1000rpm, 1050rpm, 1100rpm, 1150rpm or 1200rpm, more preferably 900rpm；
Preferably, the operating voltage for hitting skin machine is 380V；
Preferably, the size for hitting skin machine is 1.98m × 0.98m.
As optimal technical scheme, the described method comprises the following steps:
(1) it harvests: harvesting the mixture of one of growth 3 years or 3 years or more radix scutellariae or in which at least two；Example
Such as the mixture or 5 years raw radix scutellariaes of 3 years raw radix scutellariaes or 4 years raw radix scutellariaes or 3 years raw radix scutellariaes and 4 years raw radix scutellariaes and 6 years
The mixture of raw radix scutellariae and 7 years raw radix scutellariaes；
(2) it dries impurity elimination: cadmium yellow a kind of reed mentioned in ancient books being removed into seedling stubble, soil and impurity, is then dried；
(3) it rams time: cadmium yellow a kind of reed mentioned in ancient books of harvesting being dried to water content 50~95%, is then knocked the cork on its surface；
(4) hit two times: by step (1), treated that radix scutellariae is dried to water content 35~60%, then hits to the radix scutellariae
Color be in yellowish-brown, i.e., Munsell colour system chromatic value be 5Y6/ (6~8) or 7.5YR5/ (4~8)；
(5) hit three times: by step (2), treated that radix scutellariae is dried to water content 20~40%, then hits to the radix scutellariae
Color in golden yellow, i.e., Munsell colour system chromatic value be 5Y8/ (8~12), 2.5Y7/ (8~10), 2.5Y8/10 or
5Y7/8；
(6) hit four times: by step (3), treated that radix scutellariae is dried to water content 0~10%, then hits to the radix scutellariae
Color is in yellow-white, i.e., Munsell colour system chromatic value is 5Y8/ (4~6) or 2.5Y8/ (4~8).
Preferably, harvesting described in step (1) is 3 years raw radix scutellariaes raw to 5 years, preferably 4 years raw radix scutellariaes, with its root
The dark brown cork in portion is more to be advisable；
Preferably, the period of the harvesting is annual harvesting, preferably soil thaw after, soil do not emerge after thawing before,
It is germination period, Seedling Stage, withering period, diauxic growth phase or freezing season, before further preferably soil is not emerged after thawing or withered
Phase；
Preferably, removal seedling stubble described in step (2), seedling stubble stay the length of 0.1~10cm, for example, can be 0.3cm,
0.5cm、0.8cm、1.0cm、1.5cm、2.0cm、2.5cm、3.1cm、3.7cm、4.2cm、4.6cm、5.3cm、5.7cm、
6.2cm, 6.8cm, 7.3cm, 7.7cm, 8cm, 8.4cm or 9cm, preferably 0.5~2.5cm, further preferably 0.5~
0.8cm；
Wherein, impurity refers to weeds, leaf, stone, plastic cloth etc..
As optimal technical scheme, the described method comprises the following steps:
(1) harvest: harvesting growth life in 3 years to 5 years one of raw radix scutellariae or in which at least two mixture；It is described
The period of harvesting be soil thaw after do not emerge before or withering period；
(2) it dries impurity elimination: cadmium yellow a kind of reed mentioned in ancient books being removed into seedling stubble, soil and impurity, is then dried；The removal seedling stubble, seedling
Stubble stays the length of 0.1~10cm；
(3) it rams time: cadmium yellow a kind of reed mentioned in ancient books of harvesting is dried to water content 50~95%, then by its surface 80~100%
Cork knocks；
(4) hit two times: by step (1), treated that radix scutellariae is dried to water content 35~60%, then hits to the radix scutellariae
Color be in yellowish-brown, i.e., Munsell colour system chromatic value be 5Y6/ (6~8) or 7.5YR5/ (4~8)；
(5) hit three times: by step (2), treated that radix scutellariae is dried to water content 20~40%, then hits to the radix scutellariae
Color in golden yellow, i.e., Munsell colour system chromatic value be 5Y8/ (8~12), 2.5Y7/ (8~10), 2.5Y8/10 or
5Y7/8；
(6) hit four times: by step (3), treated that radix scutellariae is dried to water content 0~10%, then hits to the radix scutellariae
Color is in yellow-white, i.e., Munsell colour system chromatic value is 5Y8/ (4~6) or 2.5Y8/ (4~8).
It should be noted that a kind of reed mentioned in ancient books slag is put into rolling letter when hitting second time, third time, the 4th time during radix scutellariae Habitat producing
It is interior, frictional force is increased with benefit, removes the exocuticle of a kind of reed mentioned in ancient books body depressed area；It is preferably slow that simple revolving speed is rolled when hitting third time, the 4th time, is avoided
Revolving speed it is too fast shock and so that big radix scutellariae is fractureed, reduce a kind of reed mentioned in ancient books shipment rate.
Second aspect, the present invention provide application of the method in terms of medicinal material Habitat producing as described in relation to the first aspect.
Compared with prior art, the present invention at least has the advantages that
Radix scutellariae habitat processing method of the invention can significantly improve radix scutellariae medicinal materials by hitting Pi Sici in the suitable time
Effective component scutelloside, baicalein and wogonoside content, while improving the commodity property and commercial specification grade of radix scutellariae；
It also ensures the stability and homogeneity of quality of medicinal material, improves occupation rate of market；Method of the invention is also easy to for medicinal material being divided into
Different brackets, graduation are sold, and the comparative benefit of medicinal material is increased.
Detailed description of the invention
Fig. 1 is the measurement of 1 radix scutellariae effective component content of baicalin of comparative example 1 and embodiment.
Fig. 2 is the measurement of 1 radix scutellariae effective component radix scutellariae cellulose content of comparative example 1 and embodiment.
Fig. 3 is the measurement of 1 radix scutellariae effective component wogonoside of comparative example 1 and embodiment.
Fig. 4 is the radix scutellariae medicinal materials appearance character comparison diagram that comparative example 1 and embodiment 1 are processed.
Specific embodiment
The technical scheme of the invention is further explained by means of specific implementation.Those skilled in the art should be bright
, described examples are only for helping to understand the present invention, and should not be regarded as a specific limitation of the invention concrete restriction.
Embodiment 1
The present embodiment carries out in the Chengde county the Kuan Cheng base radix scutellariae GAP, and early spring soil excavated life in 3 years to 4 years after thawing
Raw fresh Scutellaria baicalensis 200kg (prevent drench with rain and bubble) divides or beats ridge and dries in airing field, removes seedling stubble and (stays 0.5~1.0 centimetre
Length), soil, stone and other dis-medicinal part impurity, shine to water content 80% and ram time, by the most of old of its surface
Skin (mainly exocuticle) knocks；Due to raming all over there is the impurity such as soil, so being in dark brown；Continue sunning to water content 50%
It hits two times, hits to the radix scutellariae in yellowish-brown, i.e. Munsell colour system chromatic value is 5Y6/8；Continue sunning to water content
30% hits three times, hits to golden yellow, i.e. Munsell colour system chromatic value is 5Y8/12.Sunning to water content 8% is further continued for hit
It four times, hits to the radix scutellariae in yellow-white, i.e. Munsell colour system chromatic value is 5Y8/6.
Embodiment 2
The present embodiment carries out in the Chengde county the Kuan Cheng base radix scutellariae GAP, and early spring soil is excavated 4 years before not emerging after thawing
The raw raw fresh Scutellaria baicalensis 200kg to 5 years (prevent drench with rain and bubble) divides or beats ridge in airing field sunning, removes seedling stubble and (stays 1.0
~1.5 centimetres of length), soil, stone and other dis-medicinal part impurity, shine to water content 75% and ram time, by its surface
Most of Lao Pi (mainly exocuticle) knock；Due to raming all over there is the impurity such as soil, so being in dark brown；Continue sunning extremely
Water content 45% is hit two times, is hit to the radix scutellariae in yellowish-brown, i.e. Munsell colour system chromatic value is 5Y6/6；Continue to dry
It hits three times, hits to the radix scutellariae in golden yellow, i.e. Munsell colour system chromatic value is 5Y8/8 to water content 25%.It is further continued for
Sunning is hit four times to water content 10%, is hit to the radix scutellariae in yellow-white, i.e. Munsell colour system chromatic value is 5Y8/4.
Embodiment 3
The present embodiment carries out in the Chengde county the Kuan Cheng base radix scutellariae GAP, excavates life in 5 years to sexennial fresh in germination period
Radix scutellariae 200kg (prevent drench with rain and bubble) divides or beats ridge and dries in airing field, and removal seedling stubble (stays 1.5~2.0 centimetres of length
Degree), soil, stone and other dis-medicinal part impurity, shine to water content 70% and ram time, by most of Lao Pi on its surface
(mainly exocuticle) knocks；Due to raming all over there is the impurity such as soil, so being in dark brown；Continue sunning to water content 50% to hit
It two times, hits to the radix scutellariae in yellowish-brown, i.e. Munsell colour system chromatic value is 7.5YR5/6；Continue sunning to water content
40% hits three times, hits to the radix scutellariae in golden yellow, i.e. Munsell colour system chromatic value is 2.5Y8/10.It is further continued for sunning extremely
Water content 5% is hit four times, is hit to the radix scutellariae in yellow-white, i.e. Munsell colour system chromatic value is 2.5Y8/8.
Embodiment 4
The present embodiment carries out in the Chengde Weichang base radix scutellariae GAP, and it is fresh to life in 4 years to excavate life in 3 years in Seedling Stage
Radix scutellariae 200kg (prevent drench with rain and bubble) divides or beats ridge and dries in airing field, and removal seedling stubble (stays 0.5~1.0 centimetre of length
Degree), soil, stone and other dis-medicinal part impurity, shine to water content 95% and ram time, by most of Lao Pi on its surface
(mainly exocuticle) knocks；Due to raming all over there is the impurity such as soil, so being in dark brown；Continue sunning to water content 60% to hit
It two times, hits to the radix scutellariae in yellowish-brown, i.e. Munsell colour system chromatic value is 7.5YR5/8；Continue sunning to water content
20% hits three times, hits to the radix scutellariae in golden yellow, i.e. Munsell colour system chromatic value is 2.5Y7/8.It is further continued for sunning extremely
Water content 9% is hit four times, is hit to the radix scutellariae in yellow-white, i.e. Munsell colour system chromatic value is 2.5Y8/4.
Embodiment 5
The present embodiment carries out in the Chengde Weichang base radix scutellariae GAP, and it is fresh to life in 5 years to excavate life in 4 years in withering period
Radix scutellariae 200kg (prevent drench with rain and bubble) divides or beats ridge and dries in airing field, and removal seedling stubble (stays 1.0~1.5 centimetres of length
Degree), soil, stone and other dis-medicinal part impurity, shine to water content 80% and ram time, by most of Lao Pi on its surface
(mainly exocuticle) knocks；Due to raming all over there is the impurity such as soil, so being in dark brown；Continue sunning to water content 45% to hit
It two times, hits to the radix scutellariae in yellowish-brown, i.e. Munsell colour system chromatic value is 7.5YR5/4；Continue sunning to water content
25% hits three times, hits to the radix scutellariae in golden yellow, i.e. Munsell colour system chromatic value is 5Y8/10.Sunning is further continued for containing
Water 5% is hit four times, is hit to the radix scutellariae in yellow-white, i.e. Munsell colour system chromatic value is 2.5Y8/6.
Embodiment 6
The present embodiment carries out in the Chengde Weichang base radix scutellariae GAP, and early spring soil excavated life in 5 years to 6 years after thawing
Raw fresh Scutellaria baicalensis 200kg (prevent drench with rain and bubble) divides or beats ridge and dries in airing field, removes seedling stubble and (stays 1.5~2.0 centimetres
Length), soil, stone and other dis-medicinal part impurity, shine to water content 65% and ram time, by the most of old of its surface
Skin (mainly exocuticle) knocks；Due to raming all over there is the impurity such as soil, so being in dark brown；Continue sunning to water content 35%
It hits two times, hits to the radix scutellariae in yellowish-brown, i.e. Munsell colour system chromatic value is 7.5YR5/6；Continue sunning to water content
30% hits three times, hits to the radix scutellariae in golden yellow, i.e. Munsell colour system chromatic value is 2.5Y7/10.It is further continued for sunning extremely
Water content 7% is hit four times, is hit to the radix scutellariae in yellow-white, i.e. Munsell colour system chromatic value is 5Y8/6.
Comparative example 1
This comparative example processes radix scutellariae according to existing conventional method, carries out in the Chengde Weichang base radix scutellariae GAP, early spring soil
Fresh Scutellaria baicalensis (life in 3 years to life in 4 years) 200kg of excavation (prevent drench with rain and bubble) is divided or is beaten ridge after thawing and drying by earth
Field sunning, other dis-medicinal part impurity such as removal seedling stubble, soil, stone, carries out hitting skin after sunning to water content 40~50%,
The impurity such as exocuticle, soil are mainly removed, radix scutellariae outer surface is dark brown at this time.Dried later to water content 10% hereinafter,
Complete processing.
The content of drug effect components of embodiment 1 and 1 gained radix scutellariae medicinal materials of comparative example is measured respectively, it is efficient using Waters2695
Liquid chromatograph and DAD2998 detector, the specific method is as follows:
1) prepared by test solution:
The preparation of 1 test solution of embodiment: radix scutellariae fine powder 0.1g prepared by Example 1, it is accurately weighed, it is placed in 100mL
In triangular flask, 70% ethyl alcohol 25mL is added, shakes up, ultrasonic 30min, stands clarification, supernatant is taken to filter with 0.45 μm of filter membrane
It crosses to get the test solution of embodiment 1.
The preparation of 1 test solution of comparative example: the radix scutellariae fine powder 0.1g for taking comparative example 1 to prepare, it is accurately weighed, it is placed in 100mL
In triangular flask, 70% ethyl alcohol 25mL is added, shakes up, ultrasonic 30min, stands clarification, supernatant is taken to filter with 0.45 μm of filter membrane
It crosses to get the test solution of comparative example 1.
2) chromatographic condition:
Chromatographic column selects Thermo HypersilGOLDC18 (250 × 4.6mm, 5m)；Mobile phase selects acetonitrile: water: first
Sour (15:85:0.1) carries out gradient elution；Detection wavelength is 278nm；Flow control is in 0.8mL/min；30 DEG C of column temperature；Sample introduction
Measure 6L.
It is appropriate that scutelloside, baicalein and wogonoside standard items are weighed respectively, are dissolved with methanol, accurate formulation is at concentration
The standard solution of 0.48492mg/mL, 0.1628mg/mL and 0.0396mg/mL.Using standard solution as control, to embodiment 1
It is measured with the various content of drug effect components of comparative example 1, this method is to find out that " one comments more surveys by experimental condition
Method ", it may be assumed that using a kind of test condition by single-time measurement four different effective components can be all measured content come, without
Need using four different methods in four times four kinds do not have to effective component measure respectively come.When the gradient elution of assay
Between program be shown in Table 1.
The gradient elution time-program(me) of 1 assay of table
The assay result of scutelloside, baicalein and wogonoside is as shown in Figures 1 to 3 in comparative example 1 and embodiment 1
(wherein, left side is comparative example 1, and right side is embodiment 1)；Appearance shape figure such as Fig. 4 (being above comparative example 1, lower for embodiment 1) institute
Show.The results show that the content of baicalin of comparative example 1 is about 19.3%, radix scutellariae cellulose content about 0.5073%, wogonoside is about
3.40%；The content of baicalin of embodiment 1 is about 20.36%, and radix scutellariae cellulose content about 0.7171%, wogonoside is about
3.68%；Therefore, the radix scutellariae quality that method of the invention processes is more preferable, and compared with comparative example 1, content of baicalin is increased
6.96%, radix scutellariae cellulose content increases 41.36%, and wogonoside increases 8.24%, it is seen that its content of drug effect components is more
It is high.It can visually see from Fig. 4, the radix scutellariae medicinal materials rough surface of comparative example 1, rough bark is more and brown；The radix scutellariae of embodiment 1
Medicinal material epidermis is smooth, substantially without rough bark and in yellow-white；Therefore, the appearance business for the radix scutellariae medicinal materials that method of the invention processes
Quality trait is more excellent.
Then, we choose each 50kg of radix scutellariae after embodiment 1 and the processing of comparative example 1 respectively, by embodiment 1 and comparative example
1 sample carries out the classification of radix scutellariae finished product medicinal material, grade scale regulation, and radix scutellariae is divided into " a kind of reed mentioned in ancient books " and " withered broken a kind of reed mentioned in ancient books " two specifications, " item
Lower point of four grades of a kind of reed mentioned in ancient books " item, " withered broken a kind of reed mentioned in ancient books " are specific as follows regardless of grade:
1, a kind of reed mentioned in ancient books
A kind of reed mentioned in ancient books, that is, branch a kind of reed mentioned in ancient books, sub- a kind of reed mentioned in ancient books are internal substantial new root, young root.Planting Years up to 3 years or more, adopt by spring, two season of autumn
It digs, removes aerial part, fibrous root and silt, remove rough bark, it is dry.In cone, distortion, long 8~30cm, 1~3cm of diameter.Table
Face brown color or buff have sparse excipuliform radicula trace, and there are stem trace or remaining stem foot in top, and top is rougher, there is distortion
Vertical wrinkle or irregular reticulate pattern, lower part have rift grain and scabriculous.It is golden yellow to hit skin rear surface, matter is hard and crisp, frangibility, and section is yellow
Color, intermediate rufous.Meet the above medicinal material for identifying main points and distinguish grade with properties and characteristics by size, is divided into 4 grades:
(1) level-one: dried food and nuts.In cone, top skin is rougher, there is the vertical wrinkle of apparent reticulate pattern and distortion.Lower part skin is thin
There are rift grain or wrinkle.Surface yellow or yellowish-brown, it is micro- to have yellow-white powder.Matter heavily fortified point is crisp, section buff.Gas is micro-, bitter.Item is long
15cm or more, mid diameter 1cm or more.Remove rough bark.Free from admixture damages by worms or goes mouldy.
(2) second level: dried food and nuts.In cone, top skin is rougher, there is the vertical wrinkle of apparent reticulate pattern and distortion, and lower part skin is thin
There are rift grain or wrinkle.Surface yellow or yellowish-brown, it is micro- to have yellow-white powder.Matter heavily fortified point is crisp, section buff.Gas is micro-, bitter.Item is long
8cm or more, mid diameter 1cm are hereinafter, but be not less than 0.4cm.Remove rough bark.Free from admixture damages by worms or goes mouldy.
(3) three-level: dried food and nuts.Surface is yellow or faint yellow, micro- to have yellow-white powder.Matter heavily fortified point is crisp, section yellow.The long 2cm of item with
On, mid diameter is in 0.2cm or less person and a kind of reed mentioned in ancient books to fracture point.Gas is micro-, bitter.No rough bark, disintegrating slag, impurity, is damaged by worms or mould at stem reed
Become.
(4) level Four: dried food and nuts.The long 2cm of item fracture a kind of reed mentioned in ancient books tail below, no rough bark, disintegrating slag, impurity, damage by worms or go mouldy at residual stem.
2, withered broken a kind of reed mentioned in ancient books
Gradeless and uniformly-priced goods.Dried food and nuts.The how hollow withered a kind of reed mentioned in ancient books of i.e. old root and the broken a kind of reed mentioned in ancient books of block piece, be broken tail a kind of reed mentioned in ancient books.Surface is yellow or faint yellow.Matter is hard
It is crisp.Section yellow.Gas is micro-, bitter.No rough bark, disintegrating slag, impurity, damages by worms or goes mouldy at stem reed.Withered a kind of reed mentioned in ancient books is regardless of grade.
Wherein, comparative example 1 mixes due to only having carried out simple processing, size, the non-medicinal effects such as crust and impurity compared with
More, whole medicinal material specification grade is low, and can not carry out sizing screening, and quality of medicinal material not can guarantee yet.A kind of reed mentioned in ancient books level-one of embodiment 1
It is altogether 55% with second level specific gravity, three-level specific gravity is 30%, and level Four specific gravity and withered broken a kind of reed mentioned in ancient books specific gravity are 15% altogether.It can be seen that side of the invention
Method is also easy to for medicinal material to be divided into different brackets, and graduation is sold, and increases the comparative benefit of medicinal material, guarantees the steady of quality of medicinal material
Qualitative and homogeneity.
The Applicant declares that the present invention illustrates the process method of the present invention through the above embodiments, but the present invention not office
It is limited to above-mentioned processing step, that is, does not mean that the present invention must rely on the above process steps to be carried out.Technical field
Technical staff it will be clearly understood that any improvement in the present invention, equivalence replacement and auxiliary element to raw material selected by the present invention
Addition, selection of concrete mode etc., all of which fall within the scope of protection and disclosure of the present invention.
Claims (24)
1. a kind of habitat processing method of radix scutellariae, the method includes hitting skin, which is characterized in that the skin that hits includes:
(1) it rams time: cadmium yellow a kind of reed mentioned in ancient books of harvesting being dried to water content 50~95%, is then knocked the cork on its surface；
(2) hit two times: by step (1), treated that radix scutellariae is dried to water content 35~60%, then hits to the radix scutellariae in Huang
Brown, i.e. Munsell colour system chromatic value are 5Y6/8；
(3) hit three times: by step (2), treated that radix scutellariae is dried to water content 20~40%, then hits to the radix scutellariae in gold
Yellow, i.e. Munsell colour system chromatic value are 5Y8/12；
(4) hit four times: by step (3), treated that radix scutellariae is dried to water content 0~10%, then hits to the radix scutellariae in yellowish-white
Color, i.e. Munsell colour system chromatic value are 5Y8/6.
2. the method according to claim 1, wherein step (1) sunning is sunning containing to the radix scutellariae
Water is 60~80%.
3. the method according to claim 1, wherein step (1) sunning is sunning containing to the radix scutellariae
Water is 70~80%.
4. the method according to claim 1, wherein step (1) it is described by the cork on its surface knock for by its
The cork on surface 80~100% knocks.
5. the method according to claim 1, wherein step (2) sunning is sunning containing to the radix scutellariae
Water is 40~60%.
6. the method according to claim 1, wherein step (2) sunning is sunning containing to the radix scutellariae
Water is 40~50%.
7. the method according to claim 1, wherein step (3) sunning is sunning containing to the radix scutellariae
Water is 20~30%.
8. hitting skin use the method according to claim 1, wherein described and hitting skin machine；The power for hitting skin machine
For 1.0~2.0kW.
9. according to the method described in claim 8, it is characterized in that, the power for hitting skin machine is 1.5kW or 2.0kW.
10. according to the method described in claim 8, it is characterized in that, the working speed for hitting skin machine is 800~1200rpm.
11. according to the method described in claim 8, it is characterized in that, the working speed for hitting skin machine is 900rpm.
12. according to the method described in claim 8, it is characterized in that, the operating voltage for hitting skin machine is 380V.
13. according to the method described in claim 8, it is characterized in that, the size for hitting skin machine is 1.98m × 0.98m.
14. method described according to claim 1~one of 13, which is characterized in that the described method comprises the following steps:
(1) it harvests: harvesting the mixture of one of growth 3 years or 3 years or more radix scutellariae or in which at least two；
(2) it dries impurity elimination: cadmium yellow a kind of reed mentioned in ancient books being removed into seedling stubble, soil and impurity, is then dried；
(3) it rams time: cadmium yellow a kind of reed mentioned in ancient books of harvesting is dried to water content 50~95%, then by the cork on its surface 80~100%
It knocks；
(4) hit two times: by step (1), treated that radix scutellariae is dried to water content 35~60%, then hits to the face of the radix scutellariae
Color is in yellowish-brown, i.e., Munsell colour system chromatic value is 5Y6/8；
(5) hit three times: by step (2), treated that radix scutellariae is dried to water content 20~40%, then hits to the face of the radix scutellariae
Color is 5Y8/12 in golden yellow, i.e. Munsell colour system chromatic value；
(6) hit four times: by step (3), treated that radix scutellariae is dried to water content 0~10%, then hits to the color of the radix scutellariae
In yellow-white, i.e. Munsell colour system chromatic value is 5Y8/6.
15. according to the method for claim 14, which is characterized in that harvesting described in step (1) is 3 years raw to life in 5 years
Radix scutellariae.
16. according to the method for claim 14, which is characterized in that harvesting described in step (1) is 4 years raw radix scutellariaes.
17. according to the method for claim 14, which is characterized in that the period of the harvesting is annual harvesting.
18. according to the method for claim 14, which is characterized in that the period of the harvesting be soil thaw after, soil
Before not emerging after jelly, germination period, Seedling Stage, withering period, diauxic growth phase or freezing season.
19. according to the method for claim 14, which is characterized in that the period of the harvesting is before not emerging after soil thaws
Or withering period.
20. according to the method for claim 14, which is characterized in that removal seedling stubble described in step (2), seedling stubble stays 0.1~
The length of 10cm.
21. according to the method for claim 14, which is characterized in that the seedling stubble stays the length of 0.5~2.5cm.
22. according to the method for claim 14, which is characterized in that the seedling stubble stays the length of 0.5~0.8cm.
23. according to the method for claim 14, which is characterized in that the described method comprises the following steps:
(1) harvest: harvesting growth life in 3 years to 5 years one of raw radix scutellariae or in which at least two mixture；The harvesting
Period be annual harvesting；
(2) it dries impurity elimination: cadmium yellow a kind of reed mentioned in ancient books being removed into seedling stubble, soil and impurity, is then dried；The removal seedling stubble, seedling stubble stay
The length of 0.1~10cm；
(3) it rams time: cadmium yellow a kind of reed mentioned in ancient books of harvesting is dried to water content 50~95%, then by the cork on its surface 80~100%
It knocks；
(4) hit two times: by step (1), treated that radix scutellariae is dried to water content 35~60%, then hits to the face of the radix scutellariae
Color is in yellowish-brown, i.e., Munsell colour system chromatic value is 5Y6/8；
(5) hit three times: by step (2), treated that radix scutellariae is dried to water content 20~40%, then hits to the face of the radix scutellariae
Color is 5Y8/12 in golden yellow, i.e. Munsell colour system chromatic value；
(6) hit four times: by step (3), treated that radix scutellariae is dried to water content 0~10%, then hits to the color of the radix scutellariae
In yellow-white, i.e. Munsell colour system chromatic value is 5Y8/6.
24. application of the method in terms of medicinal material Habitat producing as described in one of claim 1~23.
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| "水浇地黄芩生育规律及栽培技术的研究";杜连恩;《Journal of Hengshui Normal College》;20021231;第4卷(第4期);第59-60页。 |
| "黄芩栽培研究";刘金花，等。;《现代中药研究与实践》;20061230;第20卷(第6期);第6页左栏"5.4产地加工"。 |
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Address after: 067000 Niuquan Gou (Shangku), Shuangqiao District, Chengde City, Hebei Province Patentee after: Sinopharm group Chengde medicinal material Co.,Ltd. Country or region after: China Patentee after: CHINA NATIONAL TRADITIONAL CHINESE MEDICINE Corp. Address before: 067000 Across from the terminal station of No.10 Road, Niuquanzigou Traditional Chinese Medicine Decoction Pieces Factory, Shuangqiao District, Chengde City, Hebei Province Patentee before: China National Corp. of Traclitional & Herbal Medicine, Chengde Medicinal Material Co.,Ltd. Country or region before: China Patentee before: CHINA NATIONAL TRADITIONAL CHINESE MEDICINE Corp. |
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