CN104636618B - Radiotherapy planning system - Google Patents
Radiotherapy planning system Download PDFInfo
- Publication number
- CN104636618B CN104636618B CN201510067495.4A CN201510067495A CN104636618B CN 104636618 B CN104636618 B CN 104636618B CN 201510067495 A CN201510067495 A CN 201510067495A CN 104636618 B CN104636618 B CN 104636618B
- Authority
- CN
- China
- Prior art keywords
- tumor
- information
- radiotherapy
- radiotherapy plan
- tumor part
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
Images
Landscapes
- Radiation-Therapy Devices (AREA)
Abstract
A radiotherapy planning system, the system comprising: an input unit adapted to acquire a scanned image of a marked tumor site and preliminary radiotherapy planning information of the tumor site; the template library is suitable for storing a plurality of radiotherapy plan templates, and radiotherapy plan information of different tumor parts is stored in the radiotherapy plan templates; the template matching unit is suitable for selecting a corresponding radiotherapy plan template from a template library according to the acquired marked scanning image of the tumor part and the primary radiotherapy plan information of the tumor part; and a radiotherapy plan output unit adapted to output radiotherapy plan information acquired from the radiotherapy plan template as radiotherapy plan information of the tumor portion. The above-described approach may improve the efficiency of the deployment of radiation treatment protocols.
Description
Technical Field
The invention relates to the technical field of medical treatment, in particular to a radiotherapy planning system.
Background
Radiotherapy is an effective tumor treatment scheme which utilizes a modern high-tech computer to control advanced ray generating equipment, namely a medical electronic linear accelerator, and controls the incidence direction and the radiation area of radioactive rays to carry out no-operation, no pain, small damage and small physical consumption on tumors. Before the radiation therapy is carried out, the radiation therapy plan of each patient is designed on a computer workstation, the radiation dose of surrounding important tissues and organs is controlled within the tolerance range of normal tissues and organs while the tumor is shown to receive the radiation lethal irradiation dose.
In a radiation therapy plan, a doctor needs to give a prescription and a treatment scheme, and a physicist needs to delineate Target areas such as organs and Tumor positions, total Tumor Volume (GTV), Planned Treatment Volume (PTV), and Clinical Target Volume (CTV) according to the doctor prescription; then according to a treatment scheme, a radiation field (Beam) and a sub-field (Beam segment) are created, Dose-Volume Distribution (DVH) is checked, and if the prescription target is not met, optimization calculation is carried out until the requirement is met; the plan is then approved (approved) and the entire plan data is saved for treatment.
Therefore, in the conventional art, the determination of radiotherapy planning information of a tumor region in radiotherapy planning requires a large amount of work by a doctor and a physicist, which causes a problem of low efficiency.
Disclosure of Invention
Embodiments of the present invention address increasing the efficiency of the configuration of radiation therapy treatment plans.
In order to solve the above problem, an embodiment of the present invention provides a radiotherapy planning system, where the radiotherapy planning system includes:
an input unit adapted to acquire a scanned image of a marked tumor site and preliminary radiotherapy planning information of the tumor site;
the template library is suitable for storing a plurality of radiotherapy plan templates, and radiotherapy plan information of different tumor parts is stored in the radiotherapy plan templates;
the template matching unit is suitable for selecting a corresponding radiotherapy plan template from a template library according to the acquired marked scanning image of the tumor part and the primary radiotherapy plan information of the tumor part;
a radiotherapy plan output unit adapted to output radiotherapy plan information acquired from the radiotherapy plan template as radiotherapy plan information of the tumor portion;
optionally, the system further comprises:
the simulation unit is suitable for simulating and outputting the radiotherapy process and result of the tumor part according to the acquired information of the tumor part and the radiotherapy plan information of the tumor part;
and the adjusting unit is suitable for adjusting the information of the radiotherapy plan of the tumor part according to the acquired radiotherapy plan result of the tumor part.
Optionally, the radiotherapy planning information of the different tumor sites comprises information of a radiation field and a sub-field.
Optionally, the analog unit includes:
a segmentation subunit adapted to segment the tumor site and other sites except the tumor site from the scanned image;
a creating subunit adapted to create information of a total tumor volume using the information of the segmented tumor site, and create information of a corresponding radiation field and a sub-field using information of a radiotherapy plan of the tumor site;
a calculation subunit adapted to calculate information of dose volume distribution using the created portal, sub-portal and information of the total tumor volume;
a result generating unit adapted to derive information of a radiotherapy planning result of the tumor site based on the computed information of the dose volume distribution;
and the output display subunit is suitable for outputting and displaying the radiotherapy planning result of the tumor part.
Optionally, the radiotherapy planning system further comprises a storage unit adapted to store information of points, where the points are stored in original resolution in the contour lines of the marked tumor part and the other parts, and the curvature of the stored points is greater than a preset curvature threshold;
the segmentation subunit comprises an interpolation fitting module and a segmentation module, wherein:
the interpolation fitting module is suitable for interpolating the stored points to fit the contour lines of the tumor part and the other parts;
and the segmentation module is suitable for segmenting the tumor part and the other parts according to the fitted contour lines of the tumor part and the other parts.
Optionally, the segmentation module is adapted to segment the tumor region and the other regions according to the fitted contour lines of the tumor region and the other regions by using an automatic window width window level method.
Compared with the prior art, the technical scheme of the invention has the following advantages:
and selecting a corresponding radiotherapy plan template from a template library according to the acquired information of the primary radiotherapy plan of the tumor part, wherein the treatment scheme template comprises the information of the radiotherapy plan corresponding to the radiotherapy plan of the tumor part, so that the treatment scheme of the tumor part can be rapidly made according to the information of the typical case corresponding to the radiotherapy plan of the tumor part, and the configuration efficiency of the treatment scheme of the tumor part can be improved.
Furthermore, the accuracy of the determined radiotherapy planning information of the tumor part can be improved by adjusting the radiotherapy planning information of the tumor part according to the information of the expected treatment result of the tumor part.
Drawings
Figure 1 is a schematic structural diagram of a radiotherapy planning system in an embodiment of the present invention;
figure 2 is a schematic structural diagram of another radiation therapy planning system in an embodiment of the present invention;
FIG. 3 is a schematic illustration of a labeled tumor site and other sites used in embodiments of the present invention;
FIG. 4 is a schematic diagram of an analog unit according to an embodiment of the present invention;
fig. 5 is a DVH diagram of the radiotherapy planning results outputted from the embodiment of the present invention at the tumor site.
Detailed Description
In order to save manpower resources and improve efficiency, in the embodiment of the invention, a corresponding radiotherapy plan template is selected from a template library according to the acquired information of the primary radiotherapy plan of the tumor part, and as the treatment scheme template comprises the information of the radiotherapy plan corresponding to the radiotherapy plan of the tumor part, the treatment scheme of the tumor part can be rapidly made according to the information of a typical case corresponding to the radiotherapy plan of the tumor part, so that the making efficiency of the treatment scheme of the tumor part can be improved, and the manpower resources are saved.
In order to make the aforementioned objects, features and advantages of the present invention comprehensible, embodiments accompanied with figures are described in detail below.
Fig. 1 shows a schematic structural diagram of a radiotherapy planning system in an embodiment of the present invention. The radiotherapy planning system 100 shown in fig. 1 may include an input unit 101, a template library 102, a template matching unit 103, and a radiotherapy plan output unit 104. The template matching unit 103 is respectively connected with the input unit 101, the template library 102 and the radiotherapy plan output unit 104, wherein: an input unit 101 adapted to acquire a scanned image of the marked tumor site and preliminary radiotherapy planning information for said tumor site. The template library 102 is adapted to store a plurality of radiotherapy plan templates, and radiotherapy plan information of different tumor portions is stored in the plurality of radiotherapy plan templates. The template matching unit 103 is adapted to select a corresponding radiotherapy plan template from a template library according to the acquired scanned image of the marked tumor part and the preliminary radiotherapy plan information of the tumor part. A radiotherapy plan output unit 104 adapted to output radiotherapy plan information acquired from the radiotherapy plan template as radiotherapy plan information of the tumor portion.
In a specific implementation, the preliminary radiotherapy planning information of the tumor region acquired by the input unit 101 may be preliminary radiotherapy planning information formulated by a medical staff according to the category to which the tumor region belongs, such as three-dimensional conformal radiotherapy (3D-CRT), static intensity modulation (step-and-shot), lagomorph therapy (Arc), rotational volume intensity modulation radiotherapy, and the like.
The working principle of the radiotherapy planning system in this embodiment is further described in detail as follows:
firstly, during the influence examination of Computed Tomography (CT), Magnetic Resonance (MR), Positron Emission Tomography (PET-CT), etc., of a patient, a medical staff determines the position and size of a tumor part according to prior experience, and correspondingly stores the tumor part after marking the tumor part in a scanned image, and at the same time, the medical staff can determine the preliminary radiotherapy planning information of the tumor part according to the position and size of the tumor part, etc. When necessary, the medical staff inputs the marked images into the radiotherapy planning system in the embodiment of the present invention through the input unit 101, the preliminary radiotherapy planning information of the tumor part and the scanned image of the patient.
The template library 102 stores templates of radiotherapy plan information of various tumor parts, wherein the radiotherapy plan information of the tumor parts stored in the template library 102 is classified and stored according to different treatment modes of the tumor parts, namely three-dimensional conformal radiation therapy (3D-CRT), step-and-shot (step-and-shot), Arc (Arc), rotational volume intensity modulated radiotherapy and the like are used as primary indexes. Of course, the templates in the template library 102 may be further subdivided, such as a 3D-CRT template, a template with four fields and a template with seven fields, etc.; the ARC template can also be subdivided into forward rotation templates with a rotation angle of 0-270 degrees, reverse rotation templates with a rotation angle of 0-270 degrees, and the like.
The template matching unit 103 may find a radiotherapy plan template matching the corresponding radiotherapy plan of the tumor part by using the preliminary radiotherapy plan information of the tumor part received by the input unit 101. For example, when the preliminary radiotherapy planning information received by the input unit 101 is three-dimensional conformal radiotherapy, a radiotherapy planning template that best matches the position, size, etc. of the tumor part may be selected from templates in a list with a primary index of three-dimensional conformal radiotherapy in the template library 102.
The template library 102 stores radiotherapy plan templates including the energy and number of radiation fields and sub-fields used in the radiotherapy planning process, and information such as treatment angles. The initial creation of the template requires the specific treatment scheme of the tumor part to be summarized and classified, and key steps are extracted to obtain the template.
Figure 2 shows a schematic structural diagram of another radiotherapy planning system in an embodiment of the present invention. The radiotherapy planning system 200 shown in fig. 2 may further include a simulation unit 205 and an adjustment unit 206 in addition to the input unit 201, the template library 202, the template matching unit 203 and the radiotherapy plan output unit 204, wherein: the simulation unit 205 is connected to the input unit 201, the template matching unit 203, and the adjustment unit 206, respectively.
In a specific implementation, the simulation unit 205 is adapted to simulate and output a radiotherapy process and a radiotherapy result of the tumor part according to the acquired information of the tumor part and the radiotherapy plan information of the tumor part; an adjusting unit 206, adapted to adjust information of the radiotherapy plan of the tumor portion according to the acquired radiotherapy plan result of the tumor portion.
The working principle of the radiotherapy planning system in this embodiment is further described in detail as follows:
when the template matching unit 203 matches a corresponding radiotherapy plan template from the template library 202, the simulation unit 205 may obtain corresponding radiotherapy plan information, such as information of a radiation field, a sub-field, and a treatment angle, from the matched radiotherapy plan template, and obtain information of the current tumor part input by the input unit 201, simulate a radiotherapy process of the current tumor part, and output a radiotherapy plan result of the current tumor part obtained by simulation in a graph manner. Therefore, the radiotherapy planning result output by the simulation unit 205 is compared with the expected radiotherapy planning result by the adjusting unit 206 according to the radiotherapy planning result output by the simulation unit 205, so as to adjust the information of the radiotherapy plan of the tumor part, such as adjusting the radiation field, the sub-field and the treatment angle, so as to achieve the radiotherapy planning result meeting the requirement.
In a specific implementation, the radiotherapy planning system in this embodiment further includes a storage unit 207, adapted to store information of points, where the points are stored in the original resolution in the contour lines of the marked tumor part and the other parts, and the curvature of the stored points is greater than a preset curvature threshold. Please refer to fig. 3, wherein the contour lines of the tumor part and the other parts are automatically drawn by medical staff according to human anatomy knowledge and a computer image processing method. In this way, when storing the contour lines of the tumor portion and the other portions than the tumor portion, only the information of the partial points in the contour lines of the tumor portion and the other portions than the tumor portion can be stored, and therefore, the storage resource can be saved.
Fig. 4 shows a schematic structural diagram of an analog unit in the embodiment of the present invention. The analog unit 400 as shown in fig. 4 may include: a segmentation subunit 401, a creation subunit 402, a calculation subunit 403, a result generation unit 404, and an output display subunit 405, where: a segmentation subunit 401 adapted to segment the tumor site and other sites except the tumor site from the scanned image; a creating subunit 402 adapted to create information of a total tumor volume (GTV) using information of the segmented tumor site, and create information of a corresponding radiation field and a sub-field using information of a radiotherapy plan of the tumor site; a calculation subunit 403 adapted to calculate information of a dose volume Distribution (DVH) using the created information of the portal, the subfield and the total tumor volume (GTV); a result generation unit 404 adapted to derive information of a radiotherapy planning result for the tumor site from the computed information of the dose volume distribution; and an output display subunit 405 adapted to output and display the radiotherapy planning result of the tumor part.
In a specific implementation, in order to accurately segment a tumor region and other regions except the tumor, the segmentation sub-unit 401 in the embodiment of the present invention may further include an interpolation fitting module 4011 and a segmentation module 4012, where: an interpolation fitting module 4011, adapted to interpolate the points stored in the storage unit 207 to fit the contour lines of the tumor part and the other parts; and the segmentation module 4012 is adapted to segment the tumor part and the other parts according to the fitted contour lines of the tumor part and the other parts. The segmentation module 4012 is adapted to segment the tumor region and the other regions according to the fitted contour lines of the tumor region and the other regions by using an automatic window width level method.
The working principle of the analog unit 400 in this embodiment is as follows:
the interpolation fitting module 4011 in the segmentation subunit 401 obtains, from the storage unit, points stored at the original resolution in the marked contour lines of the tumor region and the other regions, interpolates the points stored in the storage unit, and fits the contour lines of the tumor region and the other regions. Then, the segmentation module 4012 segments the tumor part and the other parts according to the fitted contour lines of the tumor part and the other parts. The segmentation module 4012 finds out a boundary of an organ based on image gray level histogram distribution, and can achieve a better segmentation effect for organs with relatively obvious contrast such as skin, lung and the like; for organs with insignificant contrast, such as the heart, prostate, etc., segmentation may be performed using an automatic window width window level to reduce the occurrence of "missed" and "missed" segments.
After the segmentation subunit 401 segments the tumor site and other sites except the tumor site, the creation subunit 402 creates information of a total tumor volume (GTV) using information of the segmented tumor site, and creates information of a corresponding radiation field and a sub-field using information of a radiotherapy plan of the tumor site. Next, the calculation subunit 403 calculates information of dose volume Distribution (DVH) using the created information of the portal, the sub-portal and the total tumor volume (GTV). Specifically, the calculation subunit 403 determines the spatial position and size of the tumor site in the patient using the preliminarily determined tumor position and size as input parameters, and uses the determined spatial position and size as a standard cube as the boundary constraint range of the GTV. Then, the other organs in the tumor portion are removed by further using edge extraction and image segmentation in computer image processing, so that a relatively smooth shape is obtained as the tumor portion. Wherein the position of the tumor portion can be preliminarily determined from the position of the tumor site (x, y, z). The size of the tumor site is the reference three-dimensional size of the tumor, such as 5mm, 5mm and 10mm in length, width and height, respectively.
Next, the result generating unit 404 obtains information of the radiotherapy planning result of the tumor portion from the calculated dose volume Distribution (DVH) information, and outputs and displays the radiotherapy planning result of the tumor portion by the output display subunit 405. Referring to fig. 4, the output display subunit 405 outputs the information of the radiotherapy planning result simulated by the simulation unit 205 at the tumor site.
Those skilled in the art will appreciate that all or part of the steps in the methods of the above embodiments may be implemented by instructions associated with hardware via a program, which may be stored in a computer-readable storage medium, and the storage medium may include: ROM, RAM, magnetic or optical disks, and the like.
The method and system of the embodiments of the present invention have been described in detail, but the present invention is not limited thereto. Various changes and modifications may be effected therein by one skilled in the art without departing from the spirit and scope of the invention as defined in the appended claims.
Claims (3)
1. A radiotherapy planning system, comprising:
the input unit is suitable for acquiring a scanned image of a marked tumor part and primary radiotherapy plan information of the tumor part, wherein the primary radiotherapy plan information of the tumor part is a treatment mode of the tumor part, and the radiotherapy plan information of different tumor parts comprises information of a radiation field and a sub-field;
the template library is suitable for storing a plurality of radiotherapy plan templates, radiotherapy plan information of different tumor parts is stored in the radiotherapy plan templates, and the radiotherapy plan information of each tumor part is classified and stored according to different treatment modes of the tumor part;
the template matching unit is suitable for selecting a radiotherapy plan template matched with the position and the size of the tumor part from a template library according to the acquired marked scanning image of the tumor part and the primary radiotherapy plan information of the tumor part;
a radiotherapy plan output unit adapted to output radiotherapy plan information acquired from the radiotherapy plan template as radiotherapy plan information of the tumor portion;
the simulation unit is suitable for simulating and outputting the radiotherapy process and result of the tumor part according to the acquired information of the tumor part and the radiotherapy plan information of the tumor part;
the adjusting unit is suitable for adjusting the information of the radiotherapy plan of the tumor part according to the acquired radiotherapy plan result of the tumor part;
wherein the analog unit includes:
a segmentation subunit adapted to segment the tumor site and other sites except the tumor site from the scanned image;
a creating subunit adapted to create information of a total tumor volume using the information of the segmented tumor site, and create information of a corresponding radiation field and a sub-field using information of a radiotherapy plan of the tumor site;
a calculation subunit adapted to calculate information of dose volume distribution using the created portal, sub-portal and information of the total tumor volume;
a result generating unit adapted to derive information of a radiotherapy planning result of the tumor site based on the computed information of the dose volume distribution;
and the output display subunit is suitable for outputting and displaying the radiotherapy planning result of the tumor part.
2. Radiotherapy planning system according to claim 1, characterized in that the segmentation subunit comprises an interpolation fitting module and a segmentation module, wherein:
the interpolation fitting module is suitable for interpolating the stored points to fit the contour lines of the tumor part and the other parts;
and the segmentation module is suitable for segmenting the tumor part and the other parts according to the fitted contour lines of the tumor part and the other parts.
3. Radiotherapy planning system according to claim 2, characterized in that the segmentation module is adapted to segment the tumor site and the other sites according to the fitted contour lines of the tumor site and the other sites by using an automatic window width level method.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510067495.4A CN104636618B (en) | 2015-02-09 | 2015-02-09 | Radiotherapy planning system |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510067495.4A CN104636618B (en) | 2015-02-09 | 2015-02-09 | Radiotherapy planning system |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN104636618A CN104636618A (en) | 2015-05-20 |
| CN104636618B true CN104636618B (en) | 2021-04-30 |
Family
ID=53215359
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201510067495.4A Active CN104636618B (en) | 2015-02-09 | 2015-02-09 | Radiotherapy planning system |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN104636618B (en) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107229830A (en) * | 2017-06-01 | 2017-10-03 | 上海联影医疗科技有限公司 | Radiotherapy planning system and its task executing method |
| JP2019017867A (en) * | 2017-07-20 | 2019-02-07 | 株式会社東芝 | Information processing apparatus, information processing system, and program |
| CN108744313A (en) * | 2018-06-25 | 2018-11-06 | 西安大医数码科技有限公司 | Radiotherapy planning planing method, radiotherapy planning system and radiotherapy system |
| CN108922589B (en) * | 2018-06-28 | 2021-11-09 | 上海联影医疗科技股份有限公司 | Radiotherapy plan display system and storage medium |
| CN111241331A (en) * | 2020-01-14 | 2020-06-05 | 平安科技（深圳）有限公司 | Image searching method, device, equipment and medium based on artificial intelligence |
| CN111803104B (en) * | 2020-07-20 | 2021-06-11 | 上海杏脉信息科技有限公司 | Medical image display method, medium and electronic equipment |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102184334A (en) * | 2011-05-19 | 2011-09-14 | 南京航空航天大学 | Retrieval-based radiotherapy planning system and retrieval method |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB201318805D0 (en) * | 2013-10-24 | 2013-12-11 | Elekta Ab | Use of Ancillary Devices/Accessories in MR Radiotherapy Systems |
-
2015
- 2015-02-09 CN CN201510067495.4A patent/CN104636618B/en active Active
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102184334A (en) * | 2011-05-19 | 2011-09-14 | 南京航空航天大学 | Retrieval-based radiotherapy planning system and retrieval method |
Non-Patent Citations (1)
| Title |
|---|
| 一种改进的基于DP原理的分段轮廓采样算法;夏仁波等;《计算机工程与应用》;20040721;第21-24页 * |
Also Published As
| Publication number | Publication date |
|---|---|
| CN104636618A (en) | 2015-05-20 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| US10300305B2 (en) | Image guidance for radiation therapy | |
| CN104636618B (en) | Radiotherapy planning system | |
| CN114681813B (en) | Automatic radiation therapy planning system, automatic radiation therapy planning method, and storage medium | |
| CN107567343B (en) | Three-dimensional localization and tracking for adaptive radiation therapy | |
| JP6053792B2 (en) | Integration of user input and modification vector field modification in variable image registration workflow | |
| Tsuji et al. | Dosimetric evaluation of automatic segmentation for adaptive IMRT for head-and-neck cancer | |
| US8121252B2 (en) | Use of planning atlas in radiation therapy | |
| EP2721580B1 (en) | Hybrid point-based registration | |
| JP2018506349A (en) | 3D localization of moving targets for adaptive radiation therapy | |
| US10076673B2 (en) | Interactive dose gradient based optimization technique to control IMRT delivery complexity | |
| EP2686068A1 (en) | Studying dosimetric impact of motion to generate adaptive patient-specific margins in ebrt planning | |
| WO2009118020A1 (en) | 3d medical image segmentation | |
| US9563948B2 (en) | System and method of applying an arbitrary angle to reformat medical images | |
| CN113181563A (en) | Method, system and medium for planning radiotherapy dose in particle implantation tumor | |
| CN112635023B (en) | Method for generating dose prediction model of nasopharyngeal carcinoma, dose prediction method and device | |
| Lin et al. | Development of a novel post-processing treatment planning platform for 4D radiotherapy | |
| Voet | Automation of contouring and planning in radiotherapy | |
| CN117379707A (en) | Method and system for setting parameters of magnetic resonance image guided ion beam radiotherapy | |
| McNutt et al. | Advances in External Beam Radiation Therapy | |
| Yunisa et al. | Sensitivity and accuracy analysis of CT image in PRISM autocontouring using confusion matrix and ROC/AUC curve methods | |
| Acosta et al. | Explaining relationships between local dose and rectal toxicity in prostate cancer radiotherapy with voxel-based population analysis |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| CB02 | Change of applicant information |
Address after: 201807 Shanghai city Jiading District Industrial Zone Jiading Road No. 2258 Applicant after: Shanghai Lianying Medical Technology Co., Ltd Address before: 201807 Shanghai city Jiading District Industrial Zone Jiading Road No. 2258 Applicant before: SHANGHAI UNITED IMAGING HEALTHCARE Co.,Ltd. |
|
| CB02 | Change of applicant information | ||
| GR01 | Patent grant | ||
| GR01 | Patent grant |