CN104628671A - 含苯基脒结构的硝基苯噻唑羧酸酰胺类化合物及用途 - Google Patents
含苯基脒结构的硝基苯噻唑羧酸酰胺类化合物及用途 Download PDFInfo
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- CN104628671A CN104628671A CN201510072418.8A CN201510072418A CN104628671A CN 104628671 A CN104628671 A CN 104628671A CN 201510072418 A CN201510072418 A CN 201510072418A CN 104628671 A CN104628671 A CN 104628671A
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- PXXJHWLDUBFPOL-UHFFFAOYSA-N benzamidine Chemical group NC(=N)C1=CC=CC=C1 PXXJHWLDUBFPOL-UHFFFAOYSA-N 0.000 title abstract 2
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D277/56—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Description
化合物 | IC50(hSGLT2,nM) | IC50(hSGLT1,nM) |
Dapagliflozin | 1.3 | 1219 |
化合物I-1 | 7.1 | 14.4 |
化合物I-2 | 8.3 | 12.7 |
化合物I-3 | 9.6 | 10.1 |
Claims (3)
Priority Applications (1)
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CN201510072418.8A CN104628671B (zh) | 2015-02-10 | 2015-02-10 | 含苯基脒结构的硝基苯噻唑羧酸酰胺类化合物及用途 |
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CN201510072418.8A CN104628671B (zh) | 2015-02-10 | 2015-02-10 | 含苯基脒结构的硝基苯噻唑羧酸酰胺类化合物及用途 |
Publications (2)
Publication Number | Publication Date |
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CN104628671A true CN104628671A (zh) | 2015-05-20 |
CN104628671B CN104628671B (zh) | 2016-04-13 |
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Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
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CN101370796A (zh) * | 2006-01-18 | 2009-02-18 | 霍夫曼-拉罗奇有限公司 | 作为11β-HSD1抑制剂的噻唑类 |
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CN101445492A (zh) * | 2008-12-16 | 2009-06-03 | 天津药物研究院 | 酰胺基噻唑衍生物、其制备方法和用途 |
CN103827098A (zh) * | 2011-07-26 | 2014-05-28 | 赛诺菲 | 取代的3-(噻唑-4-羰基)-或者3-(噻唑-2-羰基)-氨基丙酸衍生物及其作为药物的用途 |
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