CN104606507A - Preparation method of medicament for treating vaginal candidiasis in family planning room - Google Patents
Preparation method of medicament for treating vaginal candidiasis in family planning room Download PDFInfo
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- CN104606507A CN104606507A CN201510098879.2A CN201510098879A CN104606507A CN 104606507 A CN104606507 A CN 104606507A CN 201510098879 A CN201510098879 A CN 201510098879A CN 104606507 A CN104606507 A CN 104606507A
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Abstract
The invention relates to a preparation method of a medicament for treating vaginal candidiasis in a family planning room. The method comprises the following steps: (1) weighing psychotria calocarpa kurz, calanthe discolor lindl, sheareria nana, pittosporum seeds, Chinese iris seeds, dodartia orientalis, crotalaria tetragona, ceylon persimmon sawdust, ilex latifolia thumb, tamarix chinensis, negundo chastetree leaves, nanocnide pilosa migo, ardisia brevicaulis, siebold knotweed fruit or herb, lespedeza cuneata, franchet groundcherry, pansy, Indian pentanema herb, asiatic bilberry and licorice root, adding 10 L of water, soaking for 10 hours, performing reflux heating for 3 hours, filtering, drying filter liquor by evaporation, and grinding; (2) adding 500 g of a sapium fat matrix into powder obtained in the step (1), heating, melting, fully and uniformly stirring, pouring into a mould, coating the mould with a layer of lubricating agent in advance, cooling, cutting away an overflow part by a knife, opening the mould, pushing out suppositories, and packaging to obtain 500 required suppositories.
Description
Technical field
The present invention relates to field of medicaments, relate in particular to a kind of preparation method for the treatment of the medicament of vaginal candidiasis in family planning room.
Background technology
Vulvovaginal candidiasis is commonly encountered diseases, the frequently-occurring disease of the women of child-bearing age.The women of 75% has a vaginal Candida infection in life at least, after treatment, about have 5% Patients on Recurrence.Infect modal symptom be leucorrhea many and in the scorching hot pruritus of bean dregs sample, pudendum and vagina, dysuria, pudendum ground pattern erythema, severe patient can leave over ecchymosis and frequent recurrent exerbation, has appreciable impact to the Health and Living quality of patient.
Modern medicine is treated mainly for candidiasis, and external treatment is still main method clinical at present, Main Means, such as, use antifungal agent daktarin, fluconazol, ketoconazole etc.The purposiveness of antifungal agent is very strong, has played great function in clinical treatment, and to the state of an illness from the beginning of not occurring that the some cases of patience is really effective, but along with the appearance of drug resistance, therapeutic effect lowers gradually, causes continuous recurrence.And traditional Chinese medical science relative safety is high, allergic phenomena is less, and drug resistance reduces greatly, and economically, in operation, in curative effect, convenience, safety be all worth praising highly.
Motherland's medical science is thought, primary disease is many, dirty smelly for feature with pruritus vulvae, leucorrhea, belongs to the category of the traditional Chinese medical science " pudendal pruritus ", " leukorrheal diseases ".The monilial vaginitis cause of disease mostly is damp and hot combined pathogens, the multiple abscess part of the body cavity below the umbilicus, housing the bladder, kidneys and bowels, and band is appointed in damage, damp and hotly accumulates long-pending infested, or pudendum is unclean, or occupies wetland for a long time, and wet worm grows, and causes in worm-eaten the moon.Wet, hot, sick worm grows mutually, is the main cause of primary disease.Thering is provided a kind of safe and effective Chinese medicine preparation, is the demand of extensive patients, has great social meaning.
Summary of the invention
The object of this invention is to provide a kind of preparation method for the treatment of the medicament of vulvovaginal candidiasis.
In order to realize object of the present invention, the invention provides a kind of preparation method for the treatment of the medicament of vulvovaginal candidiasis, the method comprises the following steps:
(1) little contribution 150 grams, Herba seu Radix Calanthes 100 grams, Herba Sheareriae 120 grams, 150 grams, mountain Pericarpium Citri Reticulatae Viride, Semen Iridis 80 grams, Herba Dodartiae Orientalis 200 grams, Herba sei Radix Crotalariae tetragonae 50 grams, Scobis Diospyroris Ebeni 100 grams, Camellia sinensis O. Ktze. Var. macrophylla Sieb. 150 grams, Weng Bo 50 grams, Folium Viticis Negundo 250 grams, snow medicine 120 grams, nine pipe blood 100 grams, Fructus polygoni sieboldii 150 grams, Herba Lespedezae Cuneatae 200 grams, Physalis alkekengi L. var. francheti (Mast.) Makino 100 grams, Herba Violae Hortensis 100 grams, Herba Pentanematis Indici 300 grams, Fructus Vaccinii Bracteati 100 grams, 80 grams, Radix Glycyrrhizae is taken, add 10 premium on currency and soak 10 hours, reflux 3 hours subsequently, filter, make filtrate evaporate to dryness, pulverize;
(2) in step (1) gained powder, 500 grams of oleum sapii substrate are added, after heating and melting also fully stirs evenly, in impouring mould, mould is coated with one deck lubricant in advance, lubricant is the mixed liquor of glycerol and 95 volume % ethanol, mixed proportion is 1g glycerol: 5ml ethanol, after cooling, to prune spilling part with cutter, opening mold, released by suppository, packaging, obtains required drug suppository 500.
The present invention also provides the purposes of compositions in the medicine of preparation treatment vulvovaginal candidiasis, described compositions is made up of the material of following weight portion: little contribution 10-20 part, Herba seu Radix Calanthes 5-15 part, Herba Sheareriae 10-20 part, mountain Pericarpium Citri Reticulatae Viride 10-20 part, Semen Iridis 1-10 part, Herba Dodartiae Orientalis 20-30 part, Herba sei Radix Crotalariae tetragonae 1-10 part, Scobis Diospyroris Ebeni 5-15 part, Camellia sinensis O. Ktze. Var. macrophylla Sieb. 10-20 part, father-in-law's ripple 1-10 part, Folium Viticis Negundo 20-30 part, snow medicine 10-20 part, nine pipe blood 5-15 parts, Fructus polygoni sieboldii 10-20 part, Herba Lespedezae Cuneatae 20-30 part, Physalis alkekengi L. var. francheti (Mast.) Makino 5-15 part, Herba Violae Hortensis 5-15 part, Herba Pentanematis Indici 20-30 part, Fructus Vaccinii Bracteati 5-15 part, Radix Glycyrrhizae 1-10 part.
Preferably, described compositions is made up of the material of following weight portion: little contribution 15 parts, Herba seu Radix Calanthes 10 parts, Herba Sheareriae 12 parts, 15 parts, mountain Pericarpium Citri Reticulatae Viride, Semen Iridis 8 parts, Herba Dodartiae Orientalis 20 parts, Herba sei Radix Crotalariae tetragonae 5 parts, Scobis Diospyroris Ebeni 10 parts, Camellia sinensis O. Ktze. Var. macrophylla Sieb. 15 parts, Weng Bo 5 parts, Folium Viticis Negundo 25 parts, snow medicine 12 parts, nine pipe blood 10 parts, Fructus polygoni sieboldii 15 parts, Herba Lespedezae Cuneatae 20 parts, Physalis alkekengi L. var. francheti (Mast.) Makino 10 parts, Herba Violae Hortensis 10 parts, Herba Pentanematis Indici 30 parts, Fructus Vaccinii Bracteati 10 parts, 8 parts, Radix Glycyrrhizae.
More preferably, described medicine can be tablet, dispersible tablet, capsule, soft capsule, ointment, suppository or decoction.
In the present compositions, Herba Pentanematis Indici, mountain Pericarpium Citri Reticulatae Viride, Herba Dodartiae Orientalis are monarch drug; Herba Lespedezae Cuneatae, little contribution, snow medicine, Weng Bo, Herba Sheareriae are ministerial drug; Herba seu Radix Calanthes, Semen Iridis, Herba sei Radix Crotalariae tetragonae, Scobis Diospyroris Ebeni, Camellia sinensis O. Ktze. Var. macrophylla Sieb., Folium Viticis Negundo, nine pipe blood, Fructus polygoni sieboldii, Physalis alkekengi L. var. francheti (Mast.) Makino, Herba Violae Hortensis, Fructus Vaccinii Bracteati are adjuvant drug; Radix Glycyrrhizae coordinating the actions of various ingredients in a prescription, for making medicine.
Medicament of the present invention is from entirety, full side becomes the merit of heat-clearing and toxic substances removing, invigorating the spleen for eliminating dampness, the liver and the kidney tonifying, killing parasites for relieving itching altogether, treatment vulvovaginal candidiasis evident in efficacy, and easy and simple to handle, use safety, toxic and side effects are few, clinical being easy to is promoted, and patient is easy to accept.
Detailed description of the invention
The present invention is further illustrated below by embodiment.It should be understood that embodiments of the invention are for illustration of the present invention instead of limitation of the present invention.Essence according to the present invention all belongs to the scope of protection of present invention to the simple modification that the present invention carries out.Unless otherwise stated, the percent in the present invention is percetage by weight.
The preparation of embodiment medicament of the present invention
For suppository, medicament of the present invention is prepared by following steps:
(1) little contribution 150 grams, Herba seu Radix Calanthes 100 grams, Herba Sheareriae 120 grams, 150 grams, mountain Pericarpium Citri Reticulatae Viride, Semen Iridis 80 grams, Herba Dodartiae Orientalis 200 grams, Herba sei Radix Crotalariae tetragonae 50 grams, Scobis Diospyroris Ebeni 100 grams, Camellia sinensis O. Ktze. Var. macrophylla Sieb. 150 grams, Weng Bo 50 grams, Folium Viticis Negundo 250 grams, snow medicine 120 grams, nine pipe blood 100 grams, Fructus polygoni sieboldii 150 grams, Herba Lespedezae Cuneatae 200 grams, Physalis alkekengi L. var. francheti (Mast.) Makino 100 grams, Herba Violae Hortensis 100 grams, Herba Pentanematis Indici 300 grams, Fructus Vaccinii Bracteati 100 grams, 80 grams, Radix Glycyrrhizae is taken, add 10 premium on currency and soak 10 hours, reflux 3 hours subsequently, filter, make filtrate evaporate to dryness, pulverize;
(2) in step (1) gained powder, 500 grams of oleum sapii substrate are added, after heating and melting also fully stirs evenly, in impouring mould, mould is coated with one deck lubricant in advance, lubricant is the mixed liquor of glycerol and 95 volume % ethanol, mixed proportion is 1g glycerol: 5m l ethanol, after cooling, to prune spilling part with cutter, opening mold, released by suppository, packaging, obtains required drug suppository 500.
The curative effect of experimental example medicament of the present invention
1 data and method
1.1 physical data
This group vulvovaginal candidiasis patient 80 example, all meet " vulvovaginal candidiasis diagnosis and treatment specification " (Chinese journal of obstetrics and gynecology that Chinese obstetrics and gynecology branch infectious disease cooperative groups is formulated, 2004,39 (6): 430), specific as follows:
1. symptom: pruritus vulvae, causalgia, also can with the symptom such as dysurea and sexual anhedonia; Leucorrhoea grow in quantity.
2. sign: pudendum flushing, edema, visible scratch, inside nympha and vaginal mucosa adhere to white membranoid substance, the white bean dregs sample secretions that intravaginal is more as seen, can be curdy.
3. the scraping blade fungus microscope examination positive or cultivation turn out to be Pathogenic Candida disease.
80 routine patients are divided into treatment group 40 example and matched group 40 example.Wherein minimum 20 years old of the treatment group age, maximum 43 years old, average 34.1 years old; The course of disease 3 months-3 years, average 1.6 years; Married 27 examples, unmarried 13 examples.Minimum 22 years old of matched group age, maximum 45 years old, average 33.9 years old; The course of disease 2 months-3 years, average 1.5 years; Married 28 examples, unmarried 12 examples.Two groups of patients, at the equal not statistically significant of the difference of above-mentioned each side (p > 0.05), have comparability.
1.2 observation index
1.2.1 clinical symptoms and sign scoring
Clinical symptoms and sign evaluation index is formulated, specifically in table 1 with reference to Chinese obstetrics and gynecology branch infectious disease cooperative groups " vulvovaginal candidiasis diagnosis and treatment specification " (Chinese journal of obstetrics and gynecology, 2004,39 (6): 430).Terminate with treatment before the treatment respectively to mark to patient for latter 5 days.
Table 1 Symptoms index
1.2.2 etiological examination
Carry out fungus microscope examination and fungal culture.Adopt and remove (being feminine gender), do not remove the evaluation of (being the positive) secondary standard.
1.3 Therapeutic Method
After clean period 3 days, before sleeping every night, clean pudendum.The auxiliary drug delivery instrument for the treatment of group use or 1 suppository of the present invention utilizing sanitary finger-cot for holding embodiment to be prepared are delivered to vagina depths, 1/day.Matched group uses daktarin miconazole nitrate for vagina soft capsule (authentication code: the accurate word J20090130 of traditional Chinese medicines, Xian-Janssen Pharmaceutical Ltd. produces), 1/day.Two groups was all 1 course for the treatment of with 5 days, treated 1 course for the treatment of.
1.4 criterion of therapeutical effect
1.4.1 therapeutic index
Therapeutic index is calculated according to twice scoring score value before and after treatment.
Score value × 100% before therapeutic index=(before treatment the rear score value of score value-treatment)/treatment
Recovery from illness: clinical symptoms and sign disappear; Therapeutic index >=90%;
Effective: clinical symptoms and sign are obviously improved, therapeutic index is 60%-89%;
Take a turn for the better: clinical symptoms and sign make moderate progress, and therapeutic index is 20%-59%;
Invalid: clinical symptoms and sign do not disappear or very increase the weight of, therapeutic index < 20%.
Effective percentage=(recovery from illness+effective+take a turn for the better) number of cases/total number of cases × 100%
1.4.2 mycology therapeutic evaluation
After drug withdrawal 5 days, calculate fungus clearance rate.
1.5 statistical analysis
Statistics software SPSS17.0 is adopted to carry out data analysis.Measurement data with
represent, adopt t inspection; Enumeration data adopts x
2inspection.With p < 0.05 for difference has statistical significance.2 results
2.1 clinical symptoms and sign scoring
Before and after two groups of patient treatments clinical symptoms and sign scoring score value change relatively in table 2, curative effect is in table 3.
The comparison of table 2 liang group clinical symptoms and the change of sign scoring score value
Note: compare with before treatment, * p<0.05; Compare with matched group, * * p<0.05
As can be seen from Table 2, two groups of patients score value not statistically significant before the treatment (p > 0.05).After treatment, the score value of two groups all declines, and difference has statistical significance (p<0.05), and treatment group comparatively matched group decline more obvious, group difference has statistical significance (p<0.05).
Table 3 Clinical efficacy comparison
Note: compare with matched group, * p<0.05
Table 3 shows, and the difference of two groups of patient clinical curative effects has statistical significance (p<0.05), shows that the symptom for the treatment of group takes a turn for the better and is better than matched group.
2.2 mycology curative effects
The fungus clearance rate for the treatment of group and matched group is respectively 95.0% and 82.5%, and difference has statistical significance (p<0.05), shows that curative effect of medicine of the present invention is remarkable.
Claims (4)
1. treat a preparation method for the medicament of vulvovaginal candidiasis, the method can comprise the following steps:
(1) little contribution 150 grams, Herba seu Radix Calanthes 100 grams, Herba Sheareriae 120 grams, 150 grams, mountain Pericarpium Citri Reticulatae Viride, Semen Iridis 80 grams, Herba Dodartiae Orientalis 200 grams, Herba sei Radix Crotalariae tetragonae 50 grams, Scobis Diospyroris Ebeni 100 grams, Camellia sinensis O. Ktze. Var. macrophylla Sieb. 150 grams, Weng Bo 50 grams, Folium Viticis Negundo 250 grams, snow medicine 120 grams, nine pipe blood 100 grams, Fructus polygoni sieboldii 150 grams, Herba Lespedezae Cuneatae 200 grams, Physalis alkekengi L. var. francheti (Mast.) Makino 100 grams, Herba Violae Hortensis 100 grams, Herba Pentanematis Indici 300 grams, Fructus Vaccinii Bracteati 100 grams, 80 grams, Radix Glycyrrhizae is taken, add 10 premium on currency and soak 10 hours, reflux 3 hours subsequently, filter, make filtrate evaporate to dryness, pulverize;
(2) in step (1) gained powder, 500 grams of oleum sapii substrate are added, after heating and melting also fully stirs evenly, in impouring mould, mould is coated with one deck lubricant in advance, lubricant is the mixed liquor of glycerol and 95 volume % ethanol, mixed proportion is 1g glycerol: 5ml ethanol, after cooling, to prune spilling part with cutter, opening mold, released by suppository, packaging, obtains required drug suppository 500.
2. the purposes of compositions in the medicine of preparation treatment vulvovaginal candidiasis, it is characterized in that described compositions is made up of the material of following weight portion: little contribution 10-20 part, Herba seu Radix Calanthes 5-15 part, Herba Sheareriae 10-20 part, mountain Pericarpium Citri Reticulatae Viride 10-20 part, Semen Iridis 1-10 part, Herba Dodartiae Orientalis 20-30 part, Herba sei Radix Crotalariae tetragonae 1-10 part, Scobis Diospyroris Ebeni 5-15 part, Camellia sinensis O. Ktze. Var. macrophylla Sieb. 10-20 part, father-in-law's ripple 1-10 part, Folium Viticis Negundo 20-30 part, snow medicine 10-20 part, nine pipe blood 5-15 parts, Fructus polygoni sieboldii 10-20 part, Herba Lespedezae Cuneatae 20-30 part, Physalis alkekengi L. var. francheti (Mast.) Makino 5-15 part, Herba Violae Hortensis 5-15 part, Herba Pentanematis Indici 20-30 part, Fructus Vaccinii Bracteati 5-15 part, Radix Glycyrrhizae 1-10 part.
3. purposes according to claim 2, wherein said compositions is made up of the material of following weight portion: little contribution 15 parts, Herba seu Radix Calanthes 10 parts, Herba Sheareriae 12 parts, 15 parts, mountain Pericarpium Citri Reticulatae Viride, Semen Iridis 8 parts, Herba Dodartiae Orientalis 20 parts, Herba sei Radix Crotalariae tetragonae 5 parts, Scobis Diospyroris Ebeni 10 parts, Camellia sinensis O. Ktze. Var. macrophylla Sieb. 15 parts, Weng Bo 5 parts, Folium Viticis Negundo 25 parts, snow medicine 12 parts, nine pipe blood 10 parts, Fructus polygoni sieboldii 15 parts, Herba Lespedezae Cuneatae 20 parts, Physalis alkekengi L. var. francheti (Mast.) Makino 10 parts, Herba Violae Hortensis 10 parts, Herba Pentanematis Indici 30 parts, Fructus Vaccinii Bracteati 10 parts, 8 parts, Radix Glycyrrhizae.
4. purposes according to claim 3, wherein said medicine can be tablet, dispersible tablet, capsule, soft capsule, ointment, suppository or decoction.
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Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103239659A (en) * | 2013-05-04 | 2013-08-14 | 朱秋梅 | Medicine for treating gynecologic inflammation and preparation method thereof |
| CN103536826A (en) * | 2013-10-18 | 2014-01-29 | 李佃场 | Traditional Chinese medicine composition for treating kysthitis and preparation method thereof |
| CN103908602A (en) * | 2014-04-09 | 2014-07-09 | 青岛大学医学院附属医院 | Gynecological nursing liquid and preparation method thereof |
| CN104258236A (en) * | 2014-10-09 | 2015-01-07 | 夏继云 | Traditional Chinese medicine composition for nursing vaginas of women in puerperium |
-
2015
- 2015-03-06 CN CN201510098879.2A patent/CN104606507A/en active Pending
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103239659A (en) * | 2013-05-04 | 2013-08-14 | 朱秋梅 | Medicine for treating gynecologic inflammation and preparation method thereof |
| CN103536826A (en) * | 2013-10-18 | 2014-01-29 | 李佃场 | Traditional Chinese medicine composition for treating kysthitis and preparation method thereof |
| CN103908602A (en) * | 2014-04-09 | 2014-07-09 | 青岛大学医学院附属医院 | Gynecological nursing liquid and preparation method thereof |
| CN104258236A (en) * | 2014-10-09 | 2015-01-07 | 夏继云 | Traditional Chinese medicine composition for nursing vaginas of women in puerperium |
Non-Patent Citations (2)
| Title |
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| 杨燕飞: ""香莲系列外用治疗复发性外阴阴道念珠菌病的临床研究"", 《中国优秀硕士学位论文全文数据库 医药卫生科技辑》 * |
| 王玮瑛等主编: "《西药药剂员应试指南》", 31 January 2014, 军事医学科学出版社 * |
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Application publication date: 20150513 |