CN104605864A - Hematodialysis urea real-time monitoring sensor - Google Patents
Hematodialysis urea real-time monitoring sensor Download PDFInfo
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- CN104605864A CN104605864A CN201510033526.4A CN201510033526A CN104605864A CN 104605864 A CN104605864 A CN 104605864A CN 201510033526 A CN201510033526 A CN 201510033526A CN 104605864 A CN104605864 A CN 104605864A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
- A61B5/1468—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue using chemical or electrochemical methods, e.g. by polarographic means
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Abstract
The invention provides a hematodialysis urea real-time monitoring sensor. The hematodialysis urea real-time monitoring sensor comprises a device sensor shell, a liquid inlet pipe and a liquid outlet pipe are distributed on the two sides of the device sensor shell, a liquid storage cavity is formed in the sensor shell, and the liquid inlet pipe and the liquid outlet pipe are communicated with the liquid storage cavity; a PCB chip assembling groove is formed in the top of the sensor shell and provided with a through hole communicated with the liquid storage cavity; a PCB chip is assembled in the PCB chip assembling groove and comprises a PCB, and an ion field-effect transistor, an enzyme field-effect transistor and a signal converter are integrated on the back face of the PCB; the sensor further comprises an external interface, and the input port and the output port of the PCB are fixed to the external interface. The hematodialysis urea real-time monitoring sensor is simple in structure, the monitoring result is accurate, clinic operation is convenient, the dialysis treatment process can be monitored in real time, the dialysis treatment time can be accurately controlled, and finished treatment data are acquired.
Description
Technical field
The present invention relates to the hemodialysis apparatus field of medical instruments field, specifically, is a kind of hemodialysis carbamide real-time monitoring sensing device.
Background technology
The sickness rate of the current chronic kidney hypofunction of China is higher, the sickness rate of annual every a population of one million is 100 ~ 200 people, because Chinese population radix is huge, although do not have statistics accurately at present, expert estimates that the whole nation is nearly millions of to 10,000,000 Chronic Renal Failure Patients; Patient's number that need carry out dialysis treatment accounts for 60% of renal failure number.
Hemodialysis is the first-selected therapeutic modality for the treatment of renal failure at present, and its treatment principle utilizes hemodialysis apparatus to be separated by the nuisance in blood, and body metabolism is assisted in the effect substituting kidney.In China, carrying out of hemodialysis is very general, about has this treatment of the hospital of about 1000.But hemodialysis has serious infringement to human body, while separation harmful substance, a lot of needed by human materials in blood also can run off in dialysis procedure.Therefore the dialysis treatment time is controlled, effectively but not overtime treatment, most important to dialysis treatment.
Whether completely serum urea, as the conventional index evaluated renal function, is current clinical monitoring dialysis treatment important indicator.The carbamide detection method of current existence is divided into two large classes: direct method and urease methods.Direct method is sensitive, simple, the colour stable of generation, has abnormal flavour to discharge, general clinical little use when shortcoming is heating.Urease methods advantage is that reaction is single-minded, high specificity, not by the impact of carbamide analog, when shortcoming is operating cost, and is subject to the impact of ammonia in body fluid.
No matter adopt which kind of mode to detect, the detection of current serum urea is all detect in vitro after blood sampling, and need to expend detection time, no matter adopt which kind of mode, dialysis treatment all can exist the problem of time-out treatment.
Summary of the invention
Technical problem to be solved by this invention is just to provide a kind of hemodialysis carbamide real-time monitoring sensing device, this device can monitor the serum urea content of dialysis treatment patient effectively in real time, can monitor in real time dialysis procedure, accurate control dialysis treatment time, and the treatment data that can obtain.
For solving the problems of the technologies described above, a kind of hemodialysis carbamide real-time monitoring sensing device provided by the invention, comprise device sensor outer housing, described device sensor outer housing both sides are furnished with feed tube and drain pipe respectively, be provided with liquid storage cavity in described sensor outer housing, described feed tube is communicated with liquid storage cavity respectively with drain pipe; Described sensor outer housing top is provided with PCB core sheet fitting recess, and described PCB core sheet fitting recess offers the through hole be communicated with liquid storage cavity; Described PCB core sheet is assemblied in PCB core sheet fitting recess, described PCB core sheet comprises pcb board, ion field effect transistor, enzyme field effect transistor and signal adapter is integrated with at the pcb board back side, described ion field effect transistor is connected with signal adapter input with enzyme field effect transistor outfan, described signal adapter outfan connecting PCB board outfan; Described sensor also includes external interface, and the input and output port of described pcb board is fixed on external interface place.
In technique scheme, described external interface is RJ45 interface or probe interface.
In technique scheme, described ion field effect transistor is the metal oxide semiconductor field effect tube of the grid improved, the referenced electrode of described grid and H
+ion-sensitive layer substitutes.
In technique scheme, the haptic element of described ion field effect transistor stretches in liquid storage cavity.
In technique scheme, described reference electrode and H
+ion-sensitive layer stretches in liquid storage cavity.
In technique scheme, described enzyme field effect transistor is the ISFET of a functionalization, deposited the sensitive layer that one deck is mixed by enzyme, water and PVA in the sensitizing range of sensor.
In technique scheme, the haptic element of described enzyme field effect transistor stretches in liquid storage cavity.
In technique scheme, the described sensitive layer mixed by enzyme, water and PVA stretches in liquid storage cavity.
In technique scheme, described signal adapter converts the transducer of accessible signal of communication to for signal ion field effect transistor and enzyme field effect transistor provided.
Compared with prior art, beneficial effect of the present invention is: 1) adopt ion field effect transistor and the integrated detecting sensor of enzyme field effect transistor, can monitor serum urea content in real time, accurately control the dialysis treatment time; 2) delta data of serum urea in the dialysis procedure that can effectively obtain, provides the Data support that can judge patient's renal function situation to doctor; 3) the present invention adopts ion field effect transistor and the two detection of enzyme field effect transistor, a detection, a correction, and monitoring result is accurate; 4) structure of the present invention is simple, easy to operate, and can coordinate with the external equipment such as PC, clinical manipulation is very convenient.
Accompanying drawing explanation
Fig. 1 is structural representation of the present invention;
Fig. 2 is the structural representation of sensor outer housing of the present invention;
Fig. 3 is the structural representation of PCB core sheet of the present invention;
Fig. 4 is the circuit theory schematic diagram of enzyme field effect transistor of the present invention.
In figure, 1-sensor outer housing, 2-feed tube, 3-drain pipe, 4-PCB chip fitting recess, 5-liquid storage cavity, 6-PCB chip, 6.1-pcb board, 6.2-ion field effect transistor, 6.3-enzyme field effect transistor, 6.4-signal adapter, 7-external interface.
Detailed description of the invention
Below in conjunction with accompanying drawing, specific embodiments of the invention are described in further detail:
As shown in Figure 2, hemodialysis carbamide real-time monitoring sensing device designed by the present invention, comprise device sensor outer housing 1, described device sensor outer housing 1 both sides are furnished with feed tube 2 and drain pipe 3 respectively, be provided with liquid storage cavity 5 in described sensor outer housing 1, described feed tube 2 is communicated with liquid storage cavity 5 respectively with drain pipe 3.Described sensor outer housing 1 top is provided with PCB core sheet fitting recess 4, and described PCB core sheet fitting recess 4 offers the through hole be communicated with liquid storage cavity 5.
As shown in Figure 1, Figure 3, described PCB core sheet 6 is assemblied in PCB core sheet fitting recess 4, described PCB core sheet 6 comprises pcb board 6.1, ion field effect transistor 6.2, enzyme field effect transistor 6.3 and signal adapter 6.4 is integrated with at pcb board 6.1 back side, described ion field effect transistor 6.2 is connected with signal adapter 6.4 input with enzyme field effect transistor 6.3 outfan, described signal adapter 6.4 outfan connecting PCB board 6.1 outfan; Described sensor also includes external interface 7, and the input and output port of described pcb board 6.1 is fixed on external interface 7 place.
For the ease of being connected with external equipment, described external interface 7 is RJ45 interface or probe interface.
Sensor of the present invention needs to connect external equipment work, external interface 7 has port such as power supply port, signal output port etc., corresponding with the external-connected port of pcb board 6.1 respectively.Power supply port is ion field effect transistor 6.2, enzyme field effect transistor 6.3 and signal adapter 6.4 are powered, and the voltage signal stating ion field effect transistor 6.2 and enzyme field effect transistor 6.3 output exports external equipment to by the signal output port of external interface 7 after signal adapter 6.4 is changed, undertaken storing and date processing by external equipment.
Carrying out monitoring in real time for hemodialysis process is the difficult problem that dialysis treatment field wishes to capture always.And current effective direct method and urease methods two kinds of detection methods all cannot accomplish Real-Time Monitoring.Inventor is through clinical research for many years, and ion field effect principle can be incorporated into hemodialysis monitoring by discovery, serum urea content can be converted into the signal of telecommunication like this and carry out Real-time Obtaining and process.But inventor finds after carrying out great many of experiments, simple ion field effect detection, accuracy of detection is very limited, can be subject to the impact of other material in blood, causes testing result to there is relatively large deviation.And the impact of the factor such as the difference of patient, diet, cause the composition of other material in blood and content to be uncertain, be thus difficult to accomplish accurately to detect in real time.
After experimentation for many years, inventor has found to adopt two field effect cell jointly to detect, and one is detected one for revising in the above-mentioned difficult problem of solution.Thus the present invention determines by ion field effect transistor 6.2 and the common integrated sensor that formed of enzyme field effect transistor 6.3 to monitor the scheme of carbamide.
Enzyme field effect transistor 6.3 adopts urease to detect, and its testing result is relatively accurate, is thus defined as detecting unit.And ion field effect transistor 6.2 is easily subject to the impact of other material, cause testing result deviation, thus for detecting population of ions change, as amending unit.Like this data of two unit inspections are carried out integration process, just accurately can obtain the content of serum urea, for real-time monitoring.
Enzyme field effect transistor 6.3 of the present invention preferably adopts following structure: it is the ISFET of a functionalization, deposited the sensitive layer that one deck is mixed by enzyme, water and PVA in the sensitizing range of sensor.As shown in Figure 4, flow through carbamide in the dialysis waste liquid of sensor can with sensor sedimentary deposit generation enzymatic reaction, enzymatic reaction causes the change of pH value.Then, the change transitions of pH value is the change in voltage of ISFET.So, the content of carbamide is just gone out by the change-detection of voltage.
Ion field effect transistor of the present invention 6.2 preferably adopts the metal oxide semiconductor field effect tube of the grid improved, the referenced electrode of grid of this pipe and H
+ion-sensitive layer substitutes.Along with the carrying out of dialysis, the content of serum urea can reduce gradually, and the pH value of waste liquid of so dialysing also can change thereupon, H
+the amount of ions that ion-sensitive layer can be caught also can change.So, the gate-source voltage of ion field effect transistor 6.2 can change along with the pH value change of dialysis waste liquid, the pH value of the waste liquid that just goes out to dialyse by the change-detection of voltage, thus judges the changes of contents of carbamide.
Above-mentioned two groups of data are processed, just can revise deviation, accurately obtain the content of serum urea.These date processing generally complete on external equipment.Such as, differential principle can be adopted to process for above-mentioned two groups of measurement data, overcome the error of two kinds of metering systems.
In order to make ion field effect transistor 6.2 fully can contact with dialysis waste liquid with enzyme field effect transistor 6.3, guarantee the accurate of testing result, the haptic element of described ion field effect transistor 6.2 stretches in liquid storage cavity 5, that is described reference electrode and H
+ion-sensitive layer stretches in liquid storage cavity 5; The haptic element of described enzyme field effect transistor 6.3 also stretches in liquid storage cavity 5, and namely the described sensitive layer mixed by enzyme, water and PVA stretches in liquid storage cavity 5.
The signal that ion field effect transistor 6.2 and enzyme field effect transistor 6.3 provide then preferably can be converted to the transducer of accessible signal of communication by described signal adapter 6.4.
Core of the present invention utilizes ion field effect transistor 6.2 and the two-tube detection of enzyme field effect transistor 6.3, Real-Time Monitoring serum urea, also has numerous embodiments in addition to the implementation.On the basis of the principle of the invention, any change or distortion, all belong to protection scope of the present invention.
Claims (9)
1. a hemodialysis carbamide real-time monitoring sensing device, it is characterized in that: comprise device sensor outer housing (1), described device sensor outer housing (1) both sides are furnished with feed tube (2) and drain pipe (3) respectively, be provided with liquid storage cavity (5) in described sensor outer housing (1), described feed tube (2) is communicated with liquid storage cavity (5) respectively with drain pipe (3); Described sensor outer housing (1) top is provided with PCB core sheet fitting recess (4), described PCB core sheet fitting recess (4) offers the through hole be communicated with liquid storage cavity (5); Described PCB core sheet (6) is assemblied in PCB core sheet fitting recess (4), described PCB core sheet (6) comprises pcb board (6.1), ion field effect transistor (6.2), enzyme field effect transistor (6.3) and signal adapter (6.4) is integrated with at pcb board (6.1) back side, described ion field effect transistor (6.2) is connected with signal adapter (6.4) input with enzyme field effect transistor (6.3) outfan, described signal adapter (6.4) outfan connecting PCB board (6.1) outfan; Described sensor also includes external interface (7), and the input and output port of described pcb board (6.1) is fixed on external interface (7) place.
2. hemodialysis carbamide real-time monitoring sensing device according to claim 1, is characterized in that: described external interface (7) is RJ45 interface or probe interface.
3. hemodialysis carbamide real-time monitoring sensing device according to claim 1 and 2, is characterized in that: described ion field effect transistor (6.2) is the metal oxide semiconductor field effect tube of the grid improved, the referenced electrode of described grid and H
+ion-sensitive layer substitutes.
4. hemodialysis carbamide real-time monitoring sensing device according to claim 3, is characterized in that: the haptic element of described ion field effect transistor (6.2) stretches in liquid storage cavity (5).
5. hemodialysis carbamide real-time monitoring sensing device according to claim 4, is characterized in that: described reference electrode and H
+ion-sensitive layer stretches in liquid storage cavity (5).
6. hemodialysis carbamide real-time monitoring sensing device according to claim 1 and 2, it is characterized in that: described enzyme field effect transistor (6.3) is the ISFET of a functionalization, deposited the sensitive layer that one deck is mixed by enzyme, water and PVA in the sensitizing range of sensor.
7. hemodialysis carbamide real-time monitoring sensing device according to claim 6, is characterized in that: the haptic element of described enzyme field effect transistor (6.3) stretches in liquid storage cavity (5).
8. hemodialysis carbamide real-time monitoring sensing device according to claim 7, is characterized in that: the described sensitive layer mixed by enzyme, water and PVA stretches in liquid storage cavity (5).
9. hemodialysis carbamide real-time monitoring sensing device according to claim 1 and 2, is characterized in that: described signal adapter (6.4) is the transducer signal that ion field effect transistor (6.2) and enzyme field effect transistor (6.3) provide being converted to accessible signal of communication.
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510033526.4A CN104605864A (en) | 2015-01-23 | 2015-01-23 | Hematodialysis urea real-time monitoring sensor |
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| CN201510033526.4A CN104605864A (en) | 2015-01-23 | 2015-01-23 | Hematodialysis urea real-time monitoring sensor |
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| CN201510033526.4A Pending CN104605864A (en) | 2015-01-23 | 2015-01-23 | Hematodialysis urea real-time monitoring sensor |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109498869A (en) * | 2019-01-08 | 2019-03-22 | 郑雪梅 | A kind of medicinal blood dialysis urea real-time monitoring sensing device |
| CN117179757A (en) * | 2023-09-13 | 2023-12-08 | 上海交通大学医学院附属上海儿童医学中心 | Dynamic monitoring system for blood internal environment circulation |
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|---|---|---|---|---|
| JPS62263460A (en) * | 1986-05-12 | 1987-11-16 | Mitsubishi Electric Corp | Urea measuring apparatus |
| EP0352717A2 (en) * | 1988-07-25 | 1990-01-31 | Nova Biomedical Corporation | Method, analyzer and sensor for measuring urea concentration |
| US5296122A (en) * | 1989-03-29 | 1994-03-22 | Teruaki Katsube | Apparatus for forming thin film |
| US5858186A (en) * | 1996-12-20 | 1999-01-12 | The Regents Of The University Of California | Urea biosensor for hemodialysis monitoring |
| WO1999007878A1 (en) * | 1997-08-08 | 1999-02-18 | The Victoria University Of Manchester | Ion-sensitive sensor devices and analytical methods using them |
| US20050133367A1 (en) * | 2003-12-19 | 2005-06-23 | Hsiung Shen K. | Electrical urea biosensors and its manufacturing method |
| WO2005078427A1 (en) * | 2004-02-11 | 2005-08-25 | Hemodia | Device for instantaneous and continuous measurement of substances in an aqueous phase |
| US20060096858A1 (en) * | 2004-11-08 | 2006-05-11 | Chung Yuan Christian University | Potentiometric urea sensor based on ion-selective electrode |
| CN101430303A (en) * | 2007-11-07 | 2009-05-13 | 中国科学院电子学研究所 | Single-layer functional film urease biologic sensor chip and production method thereof |
| US20090266719A1 (en) * | 2004-11-08 | 2009-10-29 | Shen-Kan Hsiung | Potentiometric Urea Sensor Based on Ion-Selective Electrode |
| CN204618247U (en) * | 2015-01-23 | 2015-09-09 | 吴晔旻 | Hemodialysis carbamide real-time monitoring sensing device |
-
2015
- 2015-01-23 CN CN201510033526.4A patent/CN104605864A/en active Pending
Patent Citations (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS62263460A (en) * | 1986-05-12 | 1987-11-16 | Mitsubishi Electric Corp | Urea measuring apparatus |
| EP0352717A2 (en) * | 1988-07-25 | 1990-01-31 | Nova Biomedical Corporation | Method, analyzer and sensor for measuring urea concentration |
| US5296122A (en) * | 1989-03-29 | 1994-03-22 | Teruaki Katsube | Apparatus for forming thin film |
| US5858186A (en) * | 1996-12-20 | 1999-01-12 | The Regents Of The University Of California | Urea biosensor for hemodialysis monitoring |
| WO1999007878A1 (en) * | 1997-08-08 | 1999-02-18 | The Victoria University Of Manchester | Ion-sensitive sensor devices and analytical methods using them |
| US20050133367A1 (en) * | 2003-12-19 | 2005-06-23 | Hsiung Shen K. | Electrical urea biosensors and its manufacturing method |
| WO2005078427A1 (en) * | 2004-02-11 | 2005-08-25 | Hemodia | Device for instantaneous and continuous measurement of substances in an aqueous phase |
| US20060096858A1 (en) * | 2004-11-08 | 2006-05-11 | Chung Yuan Christian University | Potentiometric urea sensor based on ion-selective electrode |
| US20090266719A1 (en) * | 2004-11-08 | 2009-10-29 | Shen-Kan Hsiung | Potentiometric Urea Sensor Based on Ion-Selective Electrode |
| CN101430303A (en) * | 2007-11-07 | 2009-05-13 | 中国科学院电子学研究所 | Single-layer functional film urease biologic sensor chip and production method thereof |
| CN204618247U (en) * | 2015-01-23 | 2015-09-09 | 吴晔旻 | Hemodialysis carbamide real-time monitoring sensing device |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109498869A (en) * | 2019-01-08 | 2019-03-22 | 郑雪梅 | A kind of medicinal blood dialysis urea real-time monitoring sensing device |
| CN117179757A (en) * | 2023-09-13 | 2023-12-08 | 上海交通大学医学院附属上海儿童医学中心 | Dynamic monitoring system for blood internal environment circulation |
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