CN104587412A - Mouth mucosa patch for treating tracheospasm - Google Patents
Mouth mucosa patch for treating tracheospasm Download PDFInfo
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- CN104587412A CN104587412A CN201510071593.5A CN201510071593A CN104587412A CN 104587412 A CN104587412 A CN 104587412A CN 201510071593 A CN201510071593 A CN 201510071593A CN 104587412 A CN104587412 A CN 104587412A
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Abstract
The invention discloses a mouth mucosa patch for treating tracheospasm. A total component of the patch contains 4-7% of ingredients having anesthetic, discutient and analgesic functions in percentage by weight, wherein the ingredients having anesthetic, discutient and analgesic functions are extracts of white datura flower, unprocessed radix aconiti kusnezoffii, coptis chinensis, frankincense, radix stephaniae tetrandrae, schizonepeta, fructus forsythiae, radix curcumae longae, notopterygium root and lobelia chinensis. The mouth mucosa patch disclosed by the invention can be used for effectively reducing the sensitivity of respiratory tract and preventing the adverse consequence of respiratory tract spasm.
Description
Technical field
The present invention relates to a kind of oral mucosa paster being used for the treatment of tracheospasm.
Background technology
Tracheospasm refers to trachea, bronchus, and bronchiolar smooth muscle acutely shrinks, and the luminal stenosis caused, causes airway obstruction.Main cause is because tunica mucosa tracheae is too responsive, when running into anaphylactogen or temperature Change, causes tracheospasm, mostly occurs child and allergic constitution person.
existing treatment technology many employings oral anti-allergy medicine is main, and the method drug action is comparatively slow, and the side effect of oral anti-allergy medicine is larger.
Summary of the invention
For the problems referred to above, the object of the present invention is to provide a kind of oral mucosa paster for the treatment of tracheospasm, the sensitivity of trachea can be effectively reduced, directly act on trachea, rapid-action.
Technical scheme of the present invention is achieved in that a kind for the treatment of in the total constituent of oral mucosa paster of tracheospasm includes the composition with anesthesia, detumescence, analgesic efficacy that weight ratio is 4% ~ 7%, described in have anesthesia, detumescence, analgesic efficacy composition be the extract of datura metel flower, Radix Aconiti Kusnezoffii, Rhizoma Coptidis, Olibanum, Radix Stephaniae Tetrandrae, Herba Schizonepetae, Fructus Forsythiae, Rhizoma Curcumae Longae, Rhizoma Et Radix Notopterygii, Herba Lobeliae Chinensis, composition is detected using scopolamine as the quality control of datura metel flower extract effective ingredient, composition is detected using aconitine as the quality control of Radix Aconiti Kusnezoffii extract effective ingredient, the quality control detection composition of alkali coptisine as Rhizoma Coptidis extract effective ingredient is warded off using little, composition is detected using acetic acid n-octyl as the quality control of Olibanum extract effective ingredient, composition is detected using Radix Stephaniae Tetrandrae A prime as the quality control of Radix Stephaniae Tetrandrae extract effective ingredient, composition is detected using pulegone as the quality control of Herba Schizonepetae extract effective ingredient, composition is detected using Flavonol glycoside as the quality control of Fructus Forsythiae extract effective ingredient, composition is detected using curcumin as the quality control of Rhizoma Curcumae Longae extract effective ingredient, composition is detected using Rhizoma Et Radix Notopterygii volatile oil as the quality control of Rhizoma Seu Radix Notopterygii extract effective ingredient, composition is detected using lobelia alkaloids as the quality control of Herba Lobeliae Chinensis extract effective ingredient, describedly a kind ofly treat in the total constituent of oral mucosa paster of tracheospasm, scopolamine is at percentage by weight >=0.02% of the total constituent of oral mucosa paster, aconitine is at percentage by weight >=0.05% of the total constituent of oral mucosa paster, littlely ward off percentage by weight >=0.03% of alkali coptisine at the total constituent of oral mucosa paster, acetic acid n-octyl is at percentage by weight >=0.02% of the total constituent of oral mucosa paster, Radix Stephaniae Tetrandrae A prime is at percentage by weight >=0.02% of the total constituent of oral mucosa paster, pulegone is at percentage by weight >=0.02% of the total constituent of oral mucosa paster, Flavonol glycoside is at percentage by weight >=0.02% of the total constituent of oral mucosa paster, curcumin is at percentage by weight >=0.02% of the total constituent of oral mucosa paster, Rhizoma Et Radix Notopterygii volatile oil is at percentage by weight >=0.02% of the total constituent of oral mucosa paster, lobelia alkaloids is at percentage by weight >=0.09% of the total constituent of oral mucosa paster.
Above-mentioned a kind of oral mucosa paster for the treatment of tracheospasm more specifically scheme can be: described datura metel flower extract is scopolamine extract, described Radix Aconiti Kusnezoffii extract is aconitine extract, described Rhizoma Coptidis extract is littlely ward off alkali coptisine extract, described Olibanum extract is acetic acid n-octyl extract, described Radix Stephaniae Tetrandrae extract is Radix Stephaniae Tetrandrae A prime extract, described Herba Schizonepetae extract is pulegone extract, described Fructus Forsythiae extract is Flavonol glycoside extract, described Rhizoma Curcumae Longae extract is curcumin extraction, described Rhizoma Seu Radix Notopterygii extract is Rhizoma Et Radix Notopterygii volatile oil extract, described Herba Lobeliae Chinensis extract is lobelia alkaloids extract, the usage ratio of these ten kinds of Chinese medicine extract is chosen by respective former medicine ratio, datura metel spends former medicine: the former medicine of Radix Aconiti Kusnezoffii: the former medicine of Rhizoma Coptidis: the former medicine of Olibanum: the former medicine of Radix Stephaniae Tetrandrae: the former medicine of Herba Schizonepetae: the former medicine of Fructus Forsythiae: the former medicine of Rhizoma Curcumae Longae: the former medicine of Rhizoma Et Radix Notopterygii: the former medicine=2:5:3:2:2:2:2:2:2:9 of Herba Lobeliae Chinensis.
Below feature and the control effect and mechanism of each component is introduced respectively
Datura metel flower: sweet in the mouth, warm in nature, there is sedation.Principle active component is scopolamine, has significant sedation.Electro physiology method proves, scopolamine has inhibitory action to cerebral cortex and formatio reticularis mesencephali ascending activating system; Clinical practice proves, scopolamine is to excitation, the anti-blooming effect of respiratory center and treat parkinsonian effect, all strong than atropine, can prevent the spasm of trachea.
Radix Aconiti Kusnezoffii: acrid in the mouth, hardship, hot in nature.There is narcotic analgesic, effect that spasmolytic is only jerked.Containing aconitine, stimulation is produced to the sensory nerve ending of skin, have itch, hotness, then to suppress and in local anesthesia effect.The sensitivity of teleneuron can be reduced.
Rhizoma Coptidis: bitter in the mouth, cold in nature.There is antibacterial anesthesia potency.Ward off the multiple alkaloids such as alkali coptisine, 13-methyl-.psi.-coptisine. containing little, tool is antibacterial, ease pain drawn game anaesthetic effect.Can to trachea teleneuron play anesthetic action, reduce swelling sensation of pricking.
Antalgica:
Olibanum: acrid in the mouth, hardship, tepor.There is analgesic therapy of invigorating blood circulation, effect of antibacterial convergence, therefore be ulcer sores key medicine.Containing acetic acid n-octyl, can effectively promote that polynuclear leucocyte increases, to engulf dead blood cell and cell, improve metabolism, thus play the effect of anti-inflammatory analgesic.
Radix Stephaniae Tetrandrae: acrid in the mouth, property is put down.There is analgesia, antiinflammation.Radix Stephaniae Tetrandrae total alkali and Radix Stephaniae Tetrandrae A prime, B prime, C prime all have analgesic activity, and wherein Radix Stephaniae Tetrandrae A prime, B prime have antiinflammation.The sensation of pricking of skin and trachea can be alleviated.
Herba Schizonepetae: acrid in the mouth, warm in nature.There is relieving the exterior syndrome by diaphoresis, declare effect of malicious rash.This product can impel cutaneous circulation to strengthen, and has analgesic activity.Principle active component is pulegone, can promote the healing of impaired mucosa.
Fructus Forsythiae: bitter in the mouth, is slightly cold.There is the effect of heat-clearing and toxic substances removing, dispersing swelling and dissipating binds.Principle active component is Flavonol glycoside, and this product has powerful antiinflammatory and bacteriostatic functions, has obvious exudation to aseptic inflammation, reduces the effect of lesions position capillary fragility.
Rhizoma Curcumae Longae: bitter in the mouth, warm in nature.Principle active component is curcumin, has removing blood stasis circulation of qi promoting, effect of inducing menstruation to relieve menalgia.
Rhizoma Et Radix Notopterygii: acrid in the mouth, warm in nature.Principle active component is Rhizoma Et Radix Notopterygii volatile oil, has effect of alleviating pain and detumescence; Sore swollen toxin.
Herba Lobeliae Chinensis: sweet in the mouth, property is put down.Principle active component is lobelia alkaloids, has heat-clearing and toxic substances removing; The effect of inducing diuresis to remove edema.
Specific implementation method
One, the preparation of ingredient
Scopolamine extract: aconitine extract: littlely ward off alkali coptisine extract: acetic acid n-octyl extract: Radix Stephaniae Tetrandrae A prime extract: pulegone extract: Flavonol glycoside extract: curcumin extraction: Rhizoma Et Radix Notopterygii volatile oil extract: lobelia alkaloids=2:5:3:2:2:2:2:2:2:9.
Two, a kind of oral mucosa paster preparation for the treatment of tracheospasm
Adopt said medicine to become a kind of oral mucosa paster for the treatment of tracheospasm of assignment system only to need above-mentioned Chinese medicine extract system to be assigned in oral mucosa paster, use and say that mucosa paster is affixed on medicine in oral cavity and directly acts on tracheal strips.
Three, case of illness introduce:
Yao, female, 30 years old, very responsive to temperature Change, winter, all can there is tracheospasm, the phenomenon of long-term chronic cough, be diagnosed as the tracheospasm because trachea sensitivity causes.Use oral mucosa patch treatment of the present invention, find after SM, trachea sensitivity obviously declines, and SM is after 15 days, because of the tracheospasm transference cure that sensitivity causes.
Shao, man, 27 years old, very responsive to dust, whenever sucking dust allergy source, all can there is tracheospasm.Use oral mucosa patch treatment of the present invention, find after SM, trachea sensitivity obviously declines, and finds the tracheospasm transference cure because dust causes after SM.
Wu, man, 12 years old, because trachea sensitivity causes long-term dry cough more than, and without any inflammatory symptom.Use oral mucosa patch treatment of the present invention, trachea sensitivity is obviously declined, SM is the disappearance of tracheospasm disease after 2 days.
Claims (2)
1. treat the oral mucosa paster of tracheospasm for one kind, it is characterized in that: a kind of treat in the total constituent of oral mucosa paster of tracheospasm include weight ratio be 4% ~ 7% there is anesthesia, detumescence, the composition of analgesic efficacy, described have anesthesia, detumescence, the composition of analgesic efficacy is datura metel flower, Radix Aconiti Kusnezoffii, Rhizoma Coptidis, Olibanum, Radix Stephaniae Tetrandrae, Herba Schizonepetae, Fructus Forsythiae, Rhizoma Curcumae Longae, Rhizoma Et Radix Notopterygii, the extract of Herba Lobeliae Chinensis, describedly a kind ofly treat in the total constituent of oral mucosa paster of tracheospasm, scopolamine is at percentage by weight >=0.02% of the total constituent of oral mucosa paster, aconitine is at percentage by weight >=0.05% of the total constituent of oral mucosa paster, littlely ward off percentage by weight >=0.03% of alkali coptisine at the total constituent of oral mucosa paster, acetic acid n-octyl is at percentage by weight >=0.02% of the total constituent of oral mucosa paster, Radix Stephaniae Tetrandrae A prime is at percentage by weight >=0.02% of the total constituent of oral mucosa paster, pulegone is at percentage by weight >=0.02% of the total constituent of oral mucosa paster, Flavonol glycoside is at percentage by weight >=0.02% of the total constituent of oral mucosa paster, curcumin is at percentage by weight >=0.02% of the total constituent of oral mucosa paster, Rhizoma Et Radix Notopterygii volatile oil is at percentage by weight >=0.02% of the total constituent of oral mucosa paster, lobelia alkaloids is at percentage by weight >=0.09% of the total constituent of oral mucosa paster.
2. according to a kind of oral mucosa paster for the treatment of tracheospasm described in claim one, it is characterized in that: described datura metel flower extract is scopolamine extract, described Radix Aconiti Kusnezoffii extract is aconitine extract, described Rhizoma Coptidis extract is littlely ward off alkali coptisine extract, described Olibanum extract is acetic acid n-octyl extract, described Radix Stephaniae Tetrandrae extract is Radix Stephaniae Tetrandrae A prime extract, described Herba Schizonepetae extract is pulegone extract, described Fructus Forsythiae extract is Flavonol glycoside extract, described Rhizoma Curcumae Longae extract is curcumin extraction, described Rhizoma Seu Radix Notopterygii extract is Rhizoma Et Radix Notopterygii volatile oil extract, described Herba Lobeliae Chinensis extract is lobelia alkaloids extract.
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| CN201510071593.5A CN104587412A (en) | 2015-02-11 | 2015-02-11 | Mouth mucosa patch for treating tracheospasm |
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| CN201510071593.5A CN104587412A (en) | 2015-02-11 | 2015-02-11 | Mouth mucosa patch for treating tracheospasm |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104815291A (en) * | 2015-05-26 | 2015-08-05 | 李�杰 | Oral cavity patch for relieving allergic tracheospasm |
| CN107158141A (en) * | 2017-06-06 | 2017-09-15 | 陈魏魏 | Pepper spray cleaning agent |
| CN107213216A (en) * | 2017-07-03 | 2017-09-29 | 李宝 | The buccal tablets that auxiliary treatment asthma is used |
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| CN1424112A (en) * | 2002-12-17 | 2003-06-18 | 上海医药工业研究院 | Water soluble dressing for insoluble medicines and preparation thereof |
| CN103142945A (en) * | 2013-04-05 | 2013-06-12 | 李宝 | Tear gas cleaning agent |
| CN104001123A (en) * | 2014-06-21 | 2014-08-27 | 李宝 | Police anti-explosion spray cleaning agent |
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2015
- 2015-02-11 CN CN201510071593.5A patent/CN104587412A/en active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1424112A (en) * | 2002-12-17 | 2003-06-18 | 上海医药工业研究院 | Water soluble dressing for insoluble medicines and preparation thereof |
| CN103142945A (en) * | 2013-04-05 | 2013-06-12 | 李宝 | Tear gas cleaning agent |
| CN104001123A (en) * | 2014-06-21 | 2014-08-27 | 李宝 | Police anti-explosion spray cleaning agent |
Non-Patent Citations (1)
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| 汪受传等: "小儿肺炎喘嗽中医诊疗指南", 《中医儿科杂志》 * |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104815291A (en) * | 2015-05-26 | 2015-08-05 | 李�杰 | Oral cavity patch for relieving allergic tracheospasm |
| CN107158141A (en) * | 2017-06-06 | 2017-09-15 | 陈魏魏 | Pepper spray cleaning agent |
| CN107213216A (en) * | 2017-07-03 | 2017-09-29 | 李宝 | The buccal tablets that auxiliary treatment asthma is used |
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Application publication date: 20150506 |