CN104585166A - Triazolone water dispersible granules capable of increasing heat storage suspension rate and stability and production method - Google Patents
Triazolone water dispersible granules capable of increasing heat storage suspension rate and stability and production method Download PDFInfo
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Abstract
The invention discloses triazolone water dispersible granules capable of increasing heat storage suspension rate and stability and a production method. The triazolone water dispersible granules are prepared from the following components in parts by weight: 5 parts of triazolone, 0.1 to 1 part of a wetting agent, 0.1 to 2 parts of a dispersing agent A, 0.1 to 5 parts of a dispersing agent B, 0.1 to 4 parts of an adsorbent, and 0.1 to 5 parts of a disintegrating agent; the dispersing agent A is selected from at least one of polyoxyethylene ether, phosphate polyoxyethylene and EO/PO (Ethylene Oxide/Propylene Oxide) segmented copolymer surface active agents; the dispersing agent B is selected from at least one of lignosulfonate, alkyl naphthalene sulfonate, alkyl naphthalene sulfonate formaldehyde condensates and polycarboxylate. The test shows that the effective suspension rate and mass suspension rate of the triazolone water dispersible granules at normal temperature reach more than 90% and are close to 90% under the thermal storage condition; compared with the prior art, the triazolone water dispersible granules have the advantages that the suspension rate is reduced a little, the mass suspension rate and the effective suspension rate are consistent, and the suspension rate in the thermal storing condition is high in stability.
Description
Technical field
The present invention relates to pesticidal preparations and production field thereof, be specifically related to a kind of the triazolone water dispersible granules, the production method that improve heat storage suspensibility and stability.
Background technology
Triazolone is also known as triadimefon, know-all, chemical name 1-(4-chlorophenoxy)-3,3-dimethyl-1-(1H-1,2,4-triazol-1-yl)-2-butanone, a kind of efficient, low toxicity, the low-residual developed in early 1970s by German Beyer company, the broad spectrum activity triazole bactericidal agent that the lasting period is long, interior absorption is strong, after it is absorbed by each several part of plant, can conduct in plant corpus.The control efficiency of triazolone to wheat powdery mildew, rust, smut and maize head smut, Northern leaf spot etc. is splendid, and to wheat class full rot, moire disease, root rot, and the powdery mildew etc. of melon, fruit tree, vegetables, flowers etc. all has higher control efficiency.
Follow formulations of pesticide feature, according to the physicochemical property of the former medicine of triazolone, be developed to solid pharmaceutical preparation and missible oil is ideal, at present in the majority with wetting powder, water dispersible granules, for missible oil formulation, because the solvability of triazolone in conventional organic solvent is not high, the organic solvent methyl alcohol that wherein solvability is large, dimethylbenzene, not only toxicity is higher for toluene, unfriendly to environment, and higher as missible oil solvent use cost, so domestic registration is based on solid pharmaceutical preparation.
The quality index of water dispersible granules is except the active ingredient indicated, other are as also very important in technical indicators such as suspensibility, wetting time, particle size, pH value, moisture, persistent foamability, and wherein, most important quality index is suspensibility.So-called suspensibility, just refer within a certain period of time, the pesticide active ingredient be suspended in water accounts for the ratio of the pesticide active ingredient added.Suspensibility is higher, and agricultural chemicals particle distributes more even in water, and spray concentration is more even.Suspensibility is too low, and agricultural chemicals particle is deposited in rapidly bottom sprayer, and local concentration is too high, causes field rotating medicine uneven concentration, affects control efficiency, even cause poisoning.
There is many problems in the suspensibility of current triazolone water dispersible granules: first, and FAO standard-required suspensibility detects and carries out after heat storage stability test, and a lot of enterprise only surveys the suspensibility that product is placed at normal temperature, and as quality index.In fact, the suspensibility of water dispersible granules has certain downward trend along with the prolongation of period of storage, and within the guarantee period of 2 years, general water dispersible granules product suspensibility fall is about 10%.We also should think better of the rheological parameters' change with time of suspensibility when determining this index, and on the basis of dispatching from the factory (production) product suspensibility measurement result, deduction guarantee period inner suspension rate estimates the amplitude declined; Secondly, a good product, is not only active ingredient suspensibility and wants high, to guarantee the having active ingredient of q.s to be suspended in equably in spraying liquid, and requiring that auxiliary agent, filler can suspend in water equably, auxiliary agent, filler are promoted, and active ingredient gives full play to its drug effect.Namely our said quality (weight) suspensibility and Effective Suspension rate should be basically identical.Therefore, no matter be Effective Suspension rate or quality suspensibility, be all the important indicator weighing product quality quality.
But the ubiquitous problem of commercially available triazolone water dispersible granules is exactly it, and rear suspensibility of hot storage obviously reduces, we check from market extensive sampling, although its Effective Suspension rate can reach about 80%, but the suspensibility decline especially severe after heat storage, suspensibility can reduce by 20-50% before specific heat storage, the words that particularly poor in condition, hot and humid place inventory time is long, even decline more than 50%, decline much serious than general water-dispersible grain developing agent storage rear overhang rate of floating, cause product heat storage stability seriously defective.
Summary of the invention
In view of this, the application provides a kind of the triazolone water dispersible granules, the production method that improve heat storage suspensibility and stability, by the water dispersible granules that technical scheme obtains, Effective Suspension rate and quality suspensibility all reach more than 90% at normal temperatures, and the Effective Suspension rate under heat storage condition stores suspensibility close to 90% with heat, suspensibility fall is low, and quality suspensibility is consistent with Effective Suspension rate, and heat storage suspensibility stability is high.
For solving above technical problem, technical scheme provided by the invention is a kind of triazolone water dispersible granules improving heat storage suspensibility and stability, the component of described water dispersible granules comprises with weight parts: triazolone 5 parts, wetting agent 0.1-1 part, dispersant A 0.1-2 parts, dispersant B 0.1-5 parts, 0.1-4 parts, adsorbent, disintegrant 0.1-5 parts;
Described dispersant A is that at least one is selected from polyethenoxy ether class, polyoxyethylene ether phosphate class, Pluronic PE 6800 class surfactant;
Described dispersant B is that at least one is selected from lignosulfonates, alkylnaphthalene sulfonate, alkylnaphthalene sulfonate formaldehyde condensation products, polycarboxylate.
Preferably, the component of described water dispersible granules comprises with weight parts: triazolone 5 parts, wetting agent 0.4-1 part, dispersant A 0.5-2 parts, dispersant B 0.1-4 parts, 0.2-4 parts, adsorbent, disintegrant 0.1-5 parts.
Preferably, also comprise acceptable carrier on pharmaceutics in the component of described water dispersible granules, described carrier counts 0.1-80 parts with parts by weight.
Preferably, described dispersant A has emulsification and peptizaiton.
More preferred, described dispersant A is that at least one is selected from polyaryl phenol polyethenoxy ether, polyaryl phenol polyethenoxy ether formaldehyde condensation products, alkylphenol polyoxyethylene polyethenoxy ether, fatty alcohol-polyoxyethylene ether (peregal series), aliphatic alcohol polyoxyvinethene phosphate, styryl phenol polyethenoxy ether phosphate, Pluronic PE 6800.
Preferably, described dispersant B is that at least one is selected from sodium lignin sulfonate, dispersing agent NNO, dispersing agent MF, alkylnaphthalene sulfonate condensation polymer MorwetD-425, alkylnaphthalene sulfonate condensation polymer TERSPERSE2020, polycarboxylate TERSPERSE 2700.
Preferably, described adsorbent is that at least one is selected from white carbon, modified corn starch, attapulgite.
Technical scheme also provides a kind of production method of described water dispersible granules, comprises the following steps:
(1) emulsion dispersion: mixed with dispersant A by triazolone, carries out emulsion dispersion 5-6min, forms binary mixture;
(2) absorption parcel: adsorbent added in the binary mixture in step (1), carry out stirring, adsorb, wrap up 4-6min, formation ternary mixture;
(3) premix-pulverizing-mix again: other components in formula are added in the ternary mixture in step (2), carry out 5-10min premixed, after mixing, pulverized 1-2 times by airslide disintegrating mill, after carrying out the secondary mixing of 5-10min again, form wetting powder;
(4) add water kneading: added water by the wetting powder in above-mentioned steps (3) and 10-15% to mediate, make material and water fully wetting, adopts extruding pelletization method to make plastic in cable state or strap shape softwood;
(5) granulating and drying: the softwood in step (4) is adopted rotary pelleting machine extruder grain, and particle is through vibra fluidized bed drying, and final sizing makes triazolone water dispersible granules.
Preferably, in described step (3), the degree of grinding of airslide disintegrating mill is: the particle of more than 95% is by 1000 mesh sieves.
Preferably, in described step (5), the baking temperature of vibrated fluidized bed controls below 80 DEG C.
Term " surfactant " refers to the material adding the interface state generation significant change that can make its solution system on a small quantity, has fixing hydrophilic and oleophilic group, aligns in the surface energy of solution.Hydrophilic radical is often polar group, and as carboxylic acid, sulfonic acid, sulfuric acid, amino or amido and salt thereof, hydroxyl, amide groups, ehter bond etc. also can be used as polar hydrophilic group; And hydrophobic grouping is often nonpolar hydrocarbon chain, as 8 above hydrocarbon chains of carbon atom.Surfactant is divided into ionic surfactant (comprising cationic surfactant and anion surfactant), nonionic surface active agent, amphoteric surfactant, compound surfactant, other surfactants etc.
Term " dispersant " refers to and can promote to be formed and keep a kind of surfactant of stable dispersion.Dispersant Main Function in water dispersible granules to stop its subparticle mutually to be assembled, and make its long period in the liquid-solid dispersion formed with water keep dispersed.In fact making semi-solid grease in water, be difficult to differentiation during emulsion dispersion is emulsification or dispersion, and usually used as the surfactant same material often of emulsifier or dispersant, so both put together and are referred to as emulsifying dispersant in practicality.The action principle of dispersant is substantially identical with emulsifier, and dissimilarity is that dispersed solid particle is general slightly poorer than the stability of emulsified drop.
Term " wetting agent " is for changing solid-liquid system wetting property, liquid is made more easily to soak the reagent of solid, be generally surfactant, the effect of wetting agent reduces the interfacial tension between the surface tension of liquid and solid-liquid, and liquid is easily launched on a solid surface.
Term " disintegrant " refers to and solid pharmaceutical preparation can be made to split rapidly the material being broken into fine particle in the solution, thus make the rapid solution absorption of functional component, play a role, this kind of material mostly has good water imbibition and expansibility, thus realizes the disintegration of solid pharmaceutical preparation.
Wetting agent in technical scheme, carrier, disintegrant all can one or more of acceptable component on drug of choice thing galenic pharmacy, as wetting agent can select one or more in sodium lauryl sulfate, Nekal BX, Morwet EFW, TERWET1004; Carrier can select in diatomite, bentonite, precipitated calcium carbonate, attapulgite, corn starch one or more; Disintegrant can select in ammonium sulfate, sodium sulphate one or both.In addition, described in the application, all preparations all come from commercially available.
The application compared with prior art, it is described in detail as follows: the application provides a kind of triazolone water dispersible granules improving heat storage suspensibility and stability, the component of described wherein water dispersible granules comprises with weight parts: triazolone 5 parts, wetting agent 0.1-1 part, dispersant A 0.1-2 parts, dispersant B 0.1-5 parts, 0.1-4 parts, adsorbent, disintegrant 0.1-5 parts; Described dispersant A is that at least one is selected from polyethenoxy ether class, polyoxyethylene ether phosphate class, Pluronic PE 6800 class surfactant; Described dispersant B is that at least one is selected from lignosulfonates, alkylnaphthalene sulfonate, alkylnaphthalene sulfonate formaldehyde condensation products, polycarboxylate, each component and proportioning thereof are screened by great many of experiments above, make water dispersible granules by certain mode of production simultaneously, its production method comprises emulsion dispersion, absorption parcel, premix-pulverizing-mix again, the kneading that adds water, granulating and drying obtain, and adjust production craft step and parameter by great many of experiments.Prove through test, by the water dispersible granules that technical scheme obtains, Effective Suspension rate and quality suspensibility all reach more than 90% at normal temperatures, and the Effective Suspension rate under heat storage condition stores suspensibility close to 90% with heat, compared to prior art, Suspending Rate of WG fall in technical scheme is low, and quality suspensibility is consistent with Effective Suspension rate, and heat storage suspensibility stability is high.
Embodiment
In order to make those skilled in the art understand technical scheme of the present invention better, below in conjunction with specific embodiment, the present invention is described in further detail.
Embodiment one 5% triazolone water dispersible granules, production method and every determination of quality index
A kind of triazolone water dispersible granules, is obtained by following production method:
(1) emulsion dispersion: 5.1g triazolone is mixed with 2g polyaryl base phenol polyethenoxy ether (No. 604, agriculture breast), carries out emulsion dispersion 5min, form binary mixture;
(2) absorption parcel: 4g white carbon added in said mixture, carries out stirring, adsorb, wrap up 5min, formation ternary mixture;
(3) premix-pulverizing-mix again: 4g sodium lignin sulfonate Ultrazine NA, 5g sodium sulphate, 1g Nekal BX, 78.9g bentonite are joined in ternary mixture, carry out 5-10min premixed, after mixing, pulverized 1-2 times by airslide disintegrating mill, 95% particle diameter is by after 1000 mesh sieves, after carrying out the secondary mixing of 5-10min again, form wetting powder;
(4) add water kneading: added water by the wetting powder in step (3) and 10-15% to mediate, make material and water fully wetting, adopts extruding pelletization method to make plastic in cable state or strap shape softwood;
(5) granulating and drying: the softwood in step (4) is adopted rotary pelleting machine extruder grain, and particle is through vibra fluidized bed drying, and baking temperature controls below 80 DEG C, and final sizing makes 5% triazolone water dispersible granules.
Detect above-mentioned triazolone water dispersible granules with reference to professional standard HG 3295-2001, each quality index testing result is as table 1.
Table 1---5% triazolone water dispersible granules quality index testing result
Embodiment 2 15% triazolone water dispersible granules, production method and every determination of quality index
A kind of triazolone water dispersible granules, is obtained by following production method:
(1) emulsion dispersion: mixed with 3g styrenated phenol polyoxyethylene ether phosphate (TERSPERSE2202) by 15.1g triazolone, carry out emulsion dispersion 5min, forms binary mixture;
(2) absorption parcel: 10g white carbon added in said mixture, carries out stirring, adsorb, wrap up about 5min, form ternary mixture;
(3) premix-pulverizing-mix again: by 5g dispersing agent NNO, 2g sodium lauryl sulfate, 5g sodium sulphate, 59.9g corn starch joins in ternary mixture, carry out 5-10min premixed, after mixing, pulverized 1-2 times by airslide disintegrating mill, 95% particle diameter is by after 1000 mesh sieves, after carrying out the secondary mixing of 5-10min again, form wetting powder;
(4) add water kneading: added water by the wetting powder in step (3) and 10-15% to mediate, make material and water fully wetting, adopts extruding pelletization method to make plastic in cable state or strap shape softwood;
(5) granulating and drying: the softwood in step (4) is adopted rotary pelleting machine extruder grain, and particle is through vibra fluidized bed drying, and baking temperature controls below 80 DEG C, and final sizing makes 15% triazolone water dispersible granules.
Detect above-mentioned triazolone water dispersible granules with reference to professional standard HG 3295-2001, each quality index testing result is as table 2.
Table 2---15% triazolone water dispersible granules quality index testing result
Embodiment 3 25% triazolone water dispersible granules, production method and every determination of quality index
A kind of triazolone water dispersible granules, is obtained by following production method:
(1) emulsion dispersion: 25.1g triazolone is mixed with 4g polyaryl phenol polyethenoxy ether formaldehyde condensation products (peaceful breast 36), carries out emulsion dispersion 5min, form binary mixture;
(2) absorption parcel: 15g modified corn starch added in said mixture, carries out stirring, adsorb, wrap up about 5min, form ternary mixture;
(3) premix-pulverizing-mix again: 4g alkylnaphthalene sulfonate condensation polymer (TERSPERSE2020), 2gTERWET1004,5g sodium sulphate, 44.9g precipitated calcium carbonate are joined in ternary mixture, carry out 5-10min premixed, after mixing, pulverized 1-2 times by airslide disintegrating mill, 95% particle diameter is by after 1000 mesh sieves, after carrying out the secondary mixing of 5-10min again, form wetting powder;
(4) add water kneading: added water by the wetting powder in step (3) and 10-15% to mediate, make material and water fully wetting, adopts extruding pelletization method to make plastic in cable state or strap shape softwood;
(5) granulating and drying: the softwood in step (4) is adopted rotary pelleting machine extruder grain, and particle is through vibra fluidized bed drying, and baking temperature controls below 80 DEG C, and final sizing makes 25% triazolone water dispersible granules.
Detect above-mentioned triazolone water dispersible granules with reference to professional standard HG 3295-2001, each quality index testing result is as table 3.
Table 3---25% triazolone water dispersible granules quality index testing result
Embodiment 4 35% triazolone water dispersible granules, production method and every determination of quality index
A kind of triazolone water dispersible granules, is obtained by following production method:
(1) emulsion dispersion: mixed with 5g Pluronic PE 6800 (AtlaxG-5000) by 35.1g triazolone, carry out emulsion dispersion 5min, forms binary mixture;
(2) absorption parcel: 15g attapulgite added in said mixture, carries out stirring, adsorb, wrap up 5min, formation ternary mixture;
(3) premix-pulverizing-mix again: 5g alkylnaphthalene sulfonate condensation polymer (MorwetD-425), 2gMorwetEFW, 37.9g corn starch are joined in ternary mixture, carry out 5-10min premixed, after mixing, pulverized 1-2 times by airslide disintegrating mill, 95% particle diameter is by after 1000 mesh sieves, after carrying out the secondary mixing of 5-10min again, form wetting powder;
(4) add water kneading: added water by the wetting powder in step (3) and 10-15% to mediate, make material and water fully wetting, adopts extruding pelletization method to make plastic in cable state or strap shape softwood;
(5) granulating and drying: the softwood in step (4) is adopted rotary pelleting machine extruder grain, and particle is through vibra fluidized bed drying, and baking temperature controls below 80 DEG C, and final sizing makes 35% triazolone water dispersible granules.
Detect above-mentioned triazolone water dispersible granules with reference to professional standard HG 3295-2001, each quality index testing result is as table 4.
Table 4---35% triazolone water dispersible granules quality index testing result
Embodiment 5 40% triazolone water dispersible granules, production method and every determination of quality index
A kind of triazolone water dispersible granules, is obtained by following production method:
(1) emulsion dispersion: mixed with 5g alkylphenol polyoxyethylene polyethenoxy ether (agriculture breast 1600) by 40.1g triazolone, carry out emulsion dispersion 5min, forms binary mixture;
(2) absorption parcel: 15g attapulgite added in said mixture, carries out stirring, adsorb, wrap up about 5min, form ternary mixture;
(3) premix-pulverizing-mix again: by 4g dispersing agent NNO, 3g pulls open powder, 32.9g corn starch joins in ternary mixture, carry out 5-10min premixed, after mixing, pulverized 1-2 times by airslide disintegrating mill, 95% particle diameter is by after 1000 mesh sieves, after carrying out the secondary mixing of 5-10min again, form wetting powder;
(4) add water kneading: added water by the wetting powder in step (3) and 10-15% to mediate, make material and water fully wetting, adopts extruding pelletization method to make plastic in cable state or strap shape softwood;
(5) granulating and drying: the softwood in step (4) is adopted rotary pelleting machine extruder grain, and particle is through vibra fluidized bed drying, and baking temperature controls below 80 DEG C, and final sizing makes 40% triazolone water dispersible granules.
Detect above-mentioned triazolone water dispersible granules with reference to professional standard HG 3295-2001, each quality index testing result is as table 5.
Table 5---40% triazolone water dispersible granules quality index testing result
Embodiment 6 45% triazolone water dispersible granules, production method and every determination of quality index
A kind of triazolone water dispersible granules, is obtained by following production method:
(1) emulsion dispersion: mixed with 5g aliphatic alcohol polyoxyvinethene phosphate (SEP-750) by 45.1g triazolone, carry out emulsion dispersion 5min, forms binary mixture;
(2) absorption parcel: 15g white carbon added in said mixture, carries out stirring, adsorb, wrap up about 5min, form ternary mixture;
(3) premix-pulverizing-mix again: 4g polycarboxylate TERSPERSE 2700,3g sodium lauryl sulfate, 27.9g corn starch are joined in ternary mixture, carry out 5-10min premixed, after mixing, pulverized 1-2 times by airslide disintegrating mill, 95% particle diameter is by after 1000 mesh sieves, after carrying out the secondary mixing of 5-10min again, form wetting powder;
(4) add water kneading: added water by the wetting powder in step (3) and 10-15% to mediate, make material and water fully wetting, adopts extruding pelletization method to make plastic in cable state or strap shape softwood;
(5) granulating and drying: the softwood in step (4) is adopted rotary pelleting machine extruder grain, and particle is through vibra fluidized bed drying, and baking temperature controls below 80 DEG C, and final sizing makes 45% triazolone water dispersible granules.
Detect above-mentioned triazolone water dispersible granules with reference to professional standard HG 3295-2001, each quality index testing result is as table 6.
Table 6---45% triazolone water dispersible granules quality index testing result
Embodiment 7 50% triazolone water dispersible granules, production method and every determination of quality index
A kind of triazolone water dispersible granules, is obtained by following production method:
(1) emulsion dispersion: mixed with 5g Pluronic PE 6800 (AtlaxG-5000) by 50.1g triazolone, carry out emulsion dispersion 5-8min, forms binary mixture;
(2) absorption parcel: 20g white carbon added in said mixture, carries out stirring, adsorb, wrap up 5-10min, formation ternary mixture;
(3) premix-pulverizing-mix again: 4g sodium lauryl sulfate, 10g sodium lignin sulfonate (Borresperse NA), 10.9g corn starch are joined in ternary mixture, carry out 5-10min premixed, after mixing, pulverized 1-2 times by airslide disintegrating mill, 95% particle diameter is by after 1000 mesh sieves, after carrying out the secondary mixing of 5-10min again, form trazodone wettable powder;
(4) add water kneading: added water by the wetting powder in step (3) and 10-15% to mediate, make material and water fully wetting, adopts extruding pelletization method to make plastic in cable state or strap shape softwood;
(5) granulating and drying: the softwood in step (4) is adopted rotary pelleting machine extruder grain, and particle is through vibra fluidized bed drying, and baking temperature controls below 80 DEG C, and final sizing makes 50% triazolone water dispersible granules.
Detect above-mentioned triazolone water dispersible granules with reference to professional standard HG 3295-2001, each quality index testing result is as table 7.
Table 7---50% triazolone water dispersible granules quality index testing result
Embodiment 8 50% triazolone water dispersible granules, production method and every determination of quality index
A kind of triazolone water dispersible granules, is obtained by following production method:
(1) emulsion dispersion: mixed with 5g polyaryl phenol polyethenoxy ether (SK-FS1) by 50.1g triazolone, carry out emulsion dispersion 5-8min, forms binary mixture;
(2) absorption parcel: 20g modified corn starch added in said mixture, carries out stirring, adsorb, wrap up 5-10min, formation ternary mixture;
(3) premix-pulverizing-mix again: 4g alkylnaphthalene sulfonate condensation polymer (MorwetD-425), 2gMorwetEFW, 5g ammonium sulfate, 13.9g diatomite are joined in ternary mixture, carry out 5-10min premixed, after mixing, pulverized 1-2 times by airslide disintegrating mill, 95% particle diameter is by after 1000 mesh sieves, after carrying out the secondary mixing of 5-10min again, form trazodone wettable powder;
(4) add water kneading: added water by the wetting powder in step (3) and 10-15% to mediate, make material and water fully wetting, adopts extruding pelletization method to make plastic in cable state or strap shape softwood;
(5) granulating and drying: the softwood in step (4) is adopted rotary pelleting machine extruder grain, and particle is through vibra fluidized bed drying, and baking temperature controls below 80 DEG C, and final sizing makes 50% triazolone water dispersible granules.
Detect above-mentioned triazolone water dispersible granules with reference to professional standard HG 3295-2001, each quality index testing result is as table 8.
Table 8---50% triazolone water dispersible granules quality index testing result
Embodiment 9 55% triazolone water dispersible granules, production method and every determination of quality index
A kind of triazolone water dispersible granules, is obtained by following production method:
(1) emulsion dispersion: mixed with 5g fatty alcohol-polyoxyethylene ether (peregal-30) by 55.1g triazolone, carry out emulsion dispersion 5-8min, forms binary mixture;
(2) absorption parcel: 20g white carbon powder added in said mixture, carries out stirring, adsorb, wrap up 5-10min, formation ternary mixture;
(3) premix-pulverizing-mix again: 8g dispersing agent MF, 4g are pulled open powder, 5g ammonium sulfate, 2.9g attapulgite join in ternary mixture, carry out 5-10min premixed, after mixing, pulverized 1-2 times by airslide disintegrating mill, 95% particle diameter is by after 1000 mesh sieves, after carrying out the secondary mixing of 5-10min again, form trazodone wettable powder;
(4) add water kneading: added water by the wetting powder in step (3) and 10-15% to mediate, make material and water fully wetting, adopts extruding pelletization method to make plastic in cable state or strap shape softwood;
(5) granulating and drying: the softwood in step (4) is adopted rotary pelleting machine extruder grain, and particle is through vibra fluidized bed drying, and baking temperature controls below 80 DEG C, and final sizing makes 55% triazolone water dispersible granules.
Detect above-mentioned triazolone water dispersible granules with reference to professional standard HG 3295-2001, each quality index testing result is as table 9.
Table 9---55% triazolone water dispersible granules quality index testing result
Embodiment ten 60% triazolone water dispersible granules, production method and every determination of quality index
A kind of triazolone water dispersible granules, is obtained by following production method:
(1) emulsion dispersion: mixed with 5g polyaryl phenol polyethenoxy ether (YUS-FS1) by 60.1g triazolone, carry out emulsion dispersion 5-8min, forms binary mixture;
(2) absorption parcel: 20g white carbon powder added in said mixture, carries out stirring, adsorb, wrap up 5-10min, formation ternary mixture;
(3) premix-pulverizing-mix again: 10g sodium lignin sulfonate (Ufoxane3a), 2gMorwet EFW, 2.9g corn starch are joined in ternary mixture, carry out 5-10min premixed, after mixing, pulverized 1-2 times by airslide disintegrating mill, 95% particle diameter is by after 1000 mesh sieves, after carrying out the secondary mixing of 5-10min again, form trazodone wettable powder;
(4) add water kneading: added water by the wetting powder in step (3) and 10-15% to mediate, make material and water fully wetting, adopts extruding pelletization method to make plastic in cable state or strap shape softwood;
(5) granulating and drying: the softwood in step (4) is adopted rotary pelleting machine extruder grain, and particle is through vibra fluidized bed drying, and baking temperature controls below 80 DEG C, and final sizing makes 60% triazolone water dispersible granules.
Detect above-mentioned triazolone water dispersible granules with reference to professional standard HG 3295-2001, each quality index testing result is as table 10.
Table 10---60% triazolone water dispersible granules quality index testing result
Known by the triazolone water dispersible granules quality index testing result of different quality mark in above embodiment one to embodiment ten, triazolone water dispersible granules in technical scheme, under its storage at normal temperature condition, Effective Suspension rate and quality suspensibility all reach more than 90%, and in testing result, the best reaches 95%; And under heat storage condition, its Effective Suspension rate and quality suspensibility decline little, also close to 90%, and contrast Effective Suspension rate and quality suspensibility, both data are basically identical, are also the water dispersible granules in technical scheme, its active ingredient suspensibility is high, the active ingredient that can ensure q.s is suspended in liquid equably, and other compositions such as auxiliary agent, filler in component also can suspend in water equably, and auxiliary agent, filler are promoted, and active ingredient gives full play to its drug effect.Compared to existing water dispersible granules, its heat storage suspensibility and stability higher.
Below be only the preferred embodiment of the present invention, it should be pointed out that above-mentioned preferred embodiment should not be considered as limitation of the present invention, protection scope of the present invention should be as the criterion with claim limited range.For those skilled in the art, without departing from the spirit and scope of the present invention, can also make some improvements and modifications, these improvements and modifications also should be considered as protection scope of the present invention.
Claims (10)
1. one kind is improved the triazolone water dispersible granules of heat storage suspensibility and stability, it is characterized in that: the component of described water dispersible granules comprises with weight parts: triazolone 5 parts, wetting agent 0.1-1 part, dispersant A 0.1-2 parts, dispersant B 0.1-5 parts, 0.1-4 parts, adsorbent, disintegrant 0.1-5 parts;
Described dispersant A is that at least one is selected from polyethenoxy ether class, polyoxyethylene ether phosphate class, Pluronic PE 6800 class surfactant;
Described dispersant B is that at least one is selected from lignosulfonates, alkylnaphthalene sulfonate, alkylnaphthalene sulfonate formaldehyde condensation products, polycarboxylate.
2. water dispersible granules according to claim 1, is characterized in that:
The component of described water dispersible granules comprises with weight parts: triazolone 5 parts, wetting agent 0.4-1 part, dispersant A 0.5-2 parts, dispersant B 0.1-4 parts, 0.2-4 parts, adsorbent, disintegrant 0.1-5 parts.
3. water dispersible granules according to claim 1 and 2, is characterized in that: also comprise acceptable carrier on pharmaceutics in the component of described water dispersible granules, carrier counts 0.1-80 parts with parts by weight.
4. water dispersible granules according to claim 1, is characterized in that: described dispersant A has emulsification and peptizaiton.
5. water dispersible granules according to claim 4, is characterized in that: described dispersant A is that at least one is selected from polyaryl phenol polyethenoxy ether, polyaryl phenol polyethenoxy ether formaldehyde condensation products, alkylphenol polyoxyethylene polyethenoxy ether, fatty alcohol-polyoxyethylene ether, aliphatic alcohol polyoxyvinethene phosphate, styryl phenol polyethenoxy ether phosphate, Pluronic PE 6800.
6. water dispersible granules according to claim 1, is characterized in that: described dispersant B is that at least one is selected from sodium lignin sulfonate, dispersing agent NNO, dispersing agent MF, alkylnaphthalene sulfonate condensation polymer MorwetD-425, alkylnaphthalene sulfonate condensation polymer TERSPERSE2020, polycarboxylate TERSPERSE 2700.
7. the water dispersible granules according to any one of claim 1 or 2, is characterized in that: described adsorbent is that at least one is selected from white carbon, modified corn starch, attapulgite.
8. a production method for the arbitrary described water dispersible granules of claim 1-7, is characterized in that: comprise the following steps:
(1) emulsion dispersion: mixed with dispersant A by triazolone, carries out emulsion dispersion 5-6min, forms binary mixture;
(2) absorption parcel: adsorbent added in the binary mixture in step (1), carry out stirring, adsorb, wrap up 4-6min, formation ternary mixture;
(3) premix-pulverizing-mix again: other components in formula are added in the ternary mixture in step (2), carry out 5-10min premixed, after mixing, pulverized 1-2 times by airslide disintegrating mill, after carrying out the secondary mixing of 5-10min again, form wetting powder;
(4) add water kneading: added water by the wetting powder in above-mentioned steps (3) and 10-15% to mediate, make material and water fully wetting, adopts extruding pelletization method to make plastic in cable state or strap shape softwood;
(5) granulating and drying: the softwood in step (4) is adopted rotary pelleting machine extruder grain, and particle is through vibra fluidized bed drying, and final sizing makes triazolone water dispersible granules.
9. production method according to claim 8, is characterized in that: in described step (3), the degree of grinding of airslide disintegrating mill is: the particle of more than 95% is by 1000 mesh sieves.
10. production method according to claim 9, is characterized in that: in described step (5), the baking temperature of vibrated fluidized bed controls below 80 DEG C.
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN107960663A (en) * | 2017-11-24 | 2018-04-27 | 南通励成生物工程有限公司 | Carbonic acid calcium-nutrition intensifying agent and preparation method |
| CN111116499A (en) * | 2018-10-30 | 2020-05-08 | 江苏剑牌农化股份有限公司 | Triazolone water dispersible granule bactericide with crop resistance adjusting function and preparation method thereof |
| WO2023150846A1 (en) * | 2022-02-11 | 2023-08-17 | Dva Agro Gmbh | Water-dispersible granular composition and process for preparing same |
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| WO2010095151A2 (en) * | 2009-02-20 | 2010-08-26 | Deepak Pranjivandas Shah | A novel water dispersible granular composition |
| CN102415374A (en) * | 2011-10-20 | 2012-04-18 | 迈克斯(如东)化工有限公司 | Trinexapac-ethyl water dispersible granule and preparation method thereof |
| CN103704219A (en) * | 2010-12-07 | 2014-04-09 | 陕西韦尔奇作物保护有限公司 | Bactericidal composition containing flutriafol |
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| CN101015299A (en) * | 2006-11-01 | 2007-08-15 | 张少武 | Water-dispersed granule pesticide composition and making method thereof |
| WO2010095151A2 (en) * | 2009-02-20 | 2010-08-26 | Deepak Pranjivandas Shah | A novel water dispersible granular composition |
| CN103704219A (en) * | 2010-12-07 | 2014-04-09 | 陕西韦尔奇作物保护有限公司 | Bactericidal composition containing flutriafol |
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| CN107960663A (en) * | 2017-11-24 | 2018-04-27 | 南通励成生物工程有限公司 | Carbonic acid calcium-nutrition intensifying agent and preparation method |
| CN111116499A (en) * | 2018-10-30 | 2020-05-08 | 江苏剑牌农化股份有限公司 | Triazolone water dispersible granule bactericide with crop resistance adjusting function and preparation method thereof |
| WO2023150846A1 (en) * | 2022-02-11 | 2023-08-17 | Dva Agro Gmbh | Water-dispersible granular composition and process for preparing same |
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