CN104583198A - 新吡啶衍生物 - Google Patents
新吡啶衍生物 Download PDFInfo
- Publication number
- CN104583198A CN104583198A CN201380043572.1A CN201380043572A CN104583198A CN 104583198 A CN104583198 A CN 104583198A CN 201380043572 A CN201380043572 A CN 201380043572A CN 104583198 A CN104583198 A CN 104583198A
- Authority
- CN
- China
- Prior art keywords
- chloro
- base
- cyano
- cyclopropyl
- fluoro
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- ATFYQRAETHBPPW-APWZRJJASA-N C=NCC1(CC1)NC([C@H](C[C@H](C1)Sc2cc(C(F)(F)F)ccc2Cl)N1C(C1(CC1)c(ncc(Cl)c1)c1F)=O)=O Chemical compound C=NCC1(CC1)NC([C@H](C[C@H](C1)Sc2cc(C(F)(F)F)ccc2Cl)N1C(C1(CC1)c(ncc(Cl)c1)c1F)=O)=O ATFYQRAETHBPPW-APWZRJJASA-N 0.000 description 1
- MOWPCDUKXLUXON-KNQAVFIVSA-N C[n]1ncc(-c(cc2Cl)ccc2S[C@H](C[C@H]2C(NC3(CC3)C#N)=O)CN2C(C2(CC2)c(c(F)c2)ncc2I)=O)c1 Chemical compound C[n]1ncc(-c(cc2Cl)ccc2S[C@H](C[C@H]2C(NC3(CC3)C#N)=O)CN2C(C2(CC2)c(c(F)c2)ncc2I)=O)c1 MOWPCDUKXLUXON-KNQAVFIVSA-N 0.000 description 1
- BUSFBEOHNOVXDI-IDCZIQLBSA-N N#CC1(CC1)NC([C@H](C[C@H](C1)S(c2cc(C(F)(F)F)ccc2Cl)(=O)=O)N1C(C1(CC1)C(C=C1)=NCC1Cl)=O)=O Chemical compound N#CC1(CC1)NC([C@H](C[C@H](C1)S(c2cc(C(F)(F)F)ccc2Cl)(=O)=O)N1C(C1(CC1)C(C=C1)=NCC1Cl)=O)=O BUSFBEOHNOVXDI-IDCZIQLBSA-N 0.000 description 1
- AJGQRLLAZUYHKK-AEFFLSMTSA-N N#CC1(CC1)NC([C@H](C[C@H](C1)S(c2ccccc2Cl)(=O)=O)N1C(C1(CC1)c(cc1)ncc1Cl)=O)=O Chemical compound N#CC1(CC1)NC([C@H](C[C@H](C1)S(c2ccccc2Cl)(=O)=O)N1C(C1(CC1)c(cc1)ncc1Cl)=O)=O AJGQRLLAZUYHKK-AEFFLSMTSA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/08—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing alicyclic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/444—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring heteroatom, e.g. amrinone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
- A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4841—Filling excipients; Inactive ingredients
- A61K9/4858—Organic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Diabetes (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Emergency Medicine (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Endocrinology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pyridine Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP12181247 | 2012-08-21 | ||
| EP12181247.3 | 2012-08-21 | ||
| PCT/EP2013/067218 WO2014029722A1 (en) | 2012-08-21 | 2013-08-19 | Novel pyridine derivatives |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN104583198A true CN104583198A (zh) | 2015-04-29 |
Family
ID=46851300
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201380043572.1A Pending CN104583198A (zh) | 2012-08-21 | 2013-08-19 | 新吡啶衍生物 |
Country Status (24)
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108699044A (zh) * | 2016-02-26 | 2018-10-23 | 豪夫迈·罗氏有限公司 | 新吡咯烷衍生物 |
| CN110248925A (zh) * | 2017-01-24 | 2019-09-17 | 安斯泰来制药株式会社 | 苯基二氟甲基取代脯氨酰胺化合物 |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102405211A (zh) * | 2009-04-20 | 2012-04-04 | 霍夫曼-拉罗奇有限公司 | 作为组织蛋白酶抑制剂的脯氨酸衍生物 |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SE9903610D0 (sv) | 1999-10-06 | 1999-10-06 | Astra Ab | Novel compounds II |
| AU2006204159A1 (en) | 2005-01-06 | 2006-07-13 | Astrazeneca Ab | Novel pyridine compounds |
| AU2007209051A1 (en) | 2006-01-24 | 2007-08-02 | Actelion Pharmaceuticals Ltd | Novel pyridine derivatives |
| NZ581259A (en) * | 2007-05-09 | 2012-07-27 | Vertex Pharma | Modulators of cystic fibrosis transmembrane conductance regulator |
| BRPI0820203A2 (pt) | 2007-11-30 | 2015-06-16 | Hoffmann La Roche | Compostos de pirrdina, processo para a sua preparação, composição farmacêutica que os compreende, uso de composto e método para o tratamento e/ou profilaxia de diabetes mellitus do tipo ii e outras enfermidades |
| WO2009109906A1 (en) | 2008-03-06 | 2009-09-11 | Actelion Pharmaceuticals Ltd | Pyridine compounds |
| US8394834B2 (en) * | 2009-08-25 | 2013-03-12 | Hoffman-La Roche Inc. | Pyrrolidines as NK3 receptor antagonists |
| JP6130383B2 (ja) | 2011-09-30 | 2017-05-17 | エンドゥ ファーマシューティカルズ，インコーポレイティド | ピリジン誘導体 |
-
2013
- 2013-08-19 CA CA2879796A patent/CA2879796A1/en not_active Abandoned
- 2013-08-19 JP JP2015527877A patent/JP2015530997A/ja active Pending
- 2013-08-19 TW TW102129708A patent/TW201412728A/zh unknown
- 2013-08-19 IN IN962DEN2015 patent/IN2015DN00962A/en unknown
- 2013-08-19 PE PE2015000231A patent/PE20150995A1/es not_active Application Discontinuation
- 2013-08-19 MA MA37893A patent/MA37893A1/fr unknown
- 2013-08-19 EA EA201590363A patent/EA025166B1/ru not_active IP Right Cessation
- 2013-08-19 HK HK15107145.2A patent/HK1206716A1/xx unknown
- 2013-08-19 WO PCT/EP2013/067218 patent/WO2014029722A1/en active Application Filing
- 2013-08-19 KR KR20157006927A patent/KR20150044947A/ko not_active Withdrawn
- 2013-08-19 AU AU2013305102A patent/AU2013305102A1/en not_active Abandoned
- 2013-08-19 CN CN201380043572.1A patent/CN104583198A/zh active Pending
- 2013-08-19 BR BR112015003217A patent/BR112015003217A2/pt not_active Application Discontinuation
- 2013-08-19 MX MX2015002026A patent/MX2015002026A/es unknown
- 2013-08-19 EP EP13750339.7A patent/EP2888244A1/en not_active Withdrawn
- 2013-08-19 SG SG11201500900YA patent/SG11201500900YA/en unknown
- 2013-08-20 AR ARP130102939A patent/AR092172A1/es unknown
-
2015
- 2015-01-27 ZA ZA2015/00625A patent/ZA201500625B/en unknown
- 2015-02-05 IL IL237128A patent/IL237128A0/en unknown
- 2015-02-06 PH PH12015500262A patent/PH12015500262A1/en unknown
- 2015-02-09 CO CO15025964A patent/CO7200259A2/es unknown
- 2015-02-11 CR CR20150073A patent/CR20150073A/es not_active Application Discontinuation
- 2015-02-16 CL CL2015000354A patent/CL2015000354A1/es unknown
- 2015-02-20 US US14/627,175 patent/US9409882B2/en not_active Expired - Fee Related
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102405211A (zh) * | 2009-04-20 | 2012-04-04 | 霍夫曼-拉罗奇有限公司 | 作为组织蛋白酶抑制剂的脯氨酸衍生物 |
Non-Patent Citations (1)
| Title |
|---|
| LEO A. HARDEGGER ET AL.: "Systematic Investigation of Halogen Bonding in Protein–Ligand Interactions", 《ANGEW. CHEM. INT. ED.》, vol. 50, 31 December 2011 (2011-12-31), pages 314 - 318, XP055046757, DOI: 10.1002/anie.201006781 * |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108699044A (zh) * | 2016-02-26 | 2018-10-23 | 豪夫迈·罗氏有限公司 | 新吡咯烷衍生物 |
| CN110248925A (zh) * | 2017-01-24 | 2019-09-17 | 安斯泰来制药株式会社 | 苯基二氟甲基取代脯氨酰胺化合物 |
| CN110248925B (zh) * | 2017-01-24 | 2020-07-17 | 安斯泰来制药株式会社 | 苯基二氟甲基取代脯氨酰胺化合物 |
Also Published As
| Publication number | Publication date |
|---|---|
| PE20150995A1 (es) | 2015-06-29 |
| AR092172A1 (es) | 2015-03-25 |
| HK1206716A1 (en) | 2016-01-15 |
| EA201590363A1 (ru) | 2015-06-30 |
| TW201412728A (zh) | 2014-04-01 |
| US20150307472A1 (en) | 2015-10-29 |
| IN2015DN00962A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) | 2015-06-12 |
| AU2013305102A1 (en) | 2015-02-12 |
| BR112015003217A2 (pt) | 2017-07-04 |
| CR20150073A (es) | 2015-03-13 |
| EA025166B1 (ru) | 2016-11-30 |
| IL237128A0 (en) | 2015-03-31 |
| CO7200259A2 (es) | 2015-02-27 |
| KR20150044947A (ko) | 2015-04-27 |
| ZA201500625B (en) | 2016-08-31 |
| JP2015530997A (ja) | 2015-10-29 |
| MX2015002026A (es) | 2015-06-05 |
| SG11201500900YA (en) | 2015-03-30 |
| EP2888244A1 (en) | 2015-07-01 |
| WO2014029722A1 (en) | 2014-02-27 |
| CA2879796A1 (en) | 2014-02-27 |
| CL2015000354A1 (es) | 2015-10-23 |
| US9409882B2 (en) | 2016-08-09 |
| PH12015500262A1 (en) | 2015-03-30 |
| MA37893A1 (fr) | 2017-08-31 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| EXSB | Decision made by sipo to initiate substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| REG | Reference to a national code |
Ref country code: HK Ref legal event code: DE Ref document number: 1206716 Country of ref document: HK |
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| C02 | Deemed withdrawal of patent application after publication (patent law 2001) | ||
| WD01 | Invention patent application deemed withdrawn after publication |
Application publication date: 20150429 |
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