CN104560036B - 一种以蜂蜜为碳源的碳量子点荧光标记材料及其制备方法和应用 - Google Patents
一种以蜂蜜为碳源的碳量子点荧光标记材料及其制备方法和应用 Download PDFInfo
- Publication number
- CN104560036B CN104560036B CN201410844156.8A CN201410844156A CN104560036B CN 104560036 B CN104560036 B CN 104560036B CN 201410844156 A CN201410844156 A CN 201410844156A CN 104560036 B CN104560036 B CN 104560036B
- Authority
- CN
- China
- Prior art keywords
- carbon quantum
- honey
- quantum dot
- quantum dots
- carbon source
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- VNWKTOKETHGBQD-UHFFFAOYSA-N methane Chemical compound C VNWKTOKETHGBQD-UHFFFAOYSA-N 0.000 title claims abstract description 98
- 235000012907 honey Nutrition 0.000 title claims abstract description 40
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 title claims abstract description 26
- 229910052799 carbon Inorganic materials 0.000 title claims abstract description 26
- 239000000463 material Substances 0.000 title claims abstract description 25
- 238000002360 preparation method Methods 0.000 title claims abstract description 17
- YMWUJEATGCHHMB-UHFFFAOYSA-N Dichloromethane Chemical compound ClCCl YMWUJEATGCHHMB-UHFFFAOYSA-N 0.000 claims abstract description 39
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims abstract description 19
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 18
- 239000008367 deionised water Substances 0.000 claims abstract description 14
- 229910021641 deionized water Inorganic materials 0.000 claims abstract description 14
- 239000012074 organic phase Substances 0.000 claims abstract description 13
- 239000007788 liquid Substances 0.000 claims abstract description 12
- 239000006228 supernatant Substances 0.000 claims abstract description 11
- 230000015572 biosynthetic process Effects 0.000 claims abstract description 7
- 238000003786 synthesis reaction Methods 0.000 claims abstract description 7
- 238000001914 filtration Methods 0.000 claims abstract description 5
- 238000007789 sealing Methods 0.000 claims abstract description 5
- 238000000034 method Methods 0.000 claims description 38
- 239000007850 fluorescent dye Substances 0.000 claims description 23
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 claims description 21
- 238000001215 fluorescent labelling Methods 0.000 claims description 21
- 239000000243 solution Substances 0.000 claims description 20
- 238000005119 centrifugation Methods 0.000 claims description 14
- 239000011259 mixed solution Substances 0.000 claims description 14
- 239000012528 membrane Substances 0.000 claims description 13
- 239000011148 porous material Substances 0.000 claims description 13
- 238000004458 analytical method Methods 0.000 claims description 6
- 239000000090 biomarker Substances 0.000 claims description 6
- 229910001385 heavy metal Inorganic materials 0.000 claims description 6
- 238000002372 labelling Methods 0.000 claims description 5
- 239000000203 mixture Substances 0.000 claims description 5
- 230000035484 reaction time Effects 0.000 claims description 5
- 238000010186 staining Methods 0.000 claims description 5
- 229960000935 dehydrated alcohol Drugs 0.000 claims 3
- 238000006243 chemical reaction Methods 0.000 abstract description 9
- 238000002156 mixing Methods 0.000 abstract description 5
- 239000000047 product Substances 0.000 abstract description 5
- 239000012071 phase Substances 0.000 abstract description 4
- 231100000419 toxicity Toxicity 0.000 abstract description 2
- 230000001988 toxicity Effects 0.000 abstract description 2
- 239000002245 particle Substances 0.000 description 5
- 239000002096 quantum dot Substances 0.000 description 5
- 231100000053 low toxicity Toxicity 0.000 description 4
- 230000007935 neutral effect Effects 0.000 description 4
- 239000002994 raw material Substances 0.000 description 4
- 238000004220 aggregation Methods 0.000 description 3
- 230000002776 aggregation Effects 0.000 description 3
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 description 3
- 238000003917 TEM image Methods 0.000 description 2
- 239000007864 aqueous solution Substances 0.000 description 2
- 230000009286 beneficial effect Effects 0.000 description 2
- 238000009835 boiling Methods 0.000 description 2
- 239000003153 chemical reaction reagent Substances 0.000 description 2
- 230000005284 excitation Effects 0.000 description 2
- XSQUKJJJFZCRTK-UHFFFAOYSA-N Urea Chemical compound NC(N)=O XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 description 1
- 229910052790 beryllium Inorganic materials 0.000 description 1
- ATBAMAFKBVZNFJ-UHFFFAOYSA-N beryllium atom Chemical compound [Be] ATBAMAFKBVZNFJ-UHFFFAOYSA-N 0.000 description 1
- 230000005540 biological transmission Effects 0.000 description 1
- 229910052793 cadmium Inorganic materials 0.000 description 1
- BDOSMKKIYDKNTQ-UHFFFAOYSA-N cadmium atom Chemical compound [Cd] BDOSMKKIYDKNTQ-UHFFFAOYSA-N 0.000 description 1
- 239000004202 carbamide Substances 0.000 description 1
- 239000003575 carbonaceous material Substances 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 239000012141 concentrate Substances 0.000 description 1
- 238000000502 dialysis Methods 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 239000012467 final product Substances 0.000 description 1
- 238000002189 fluorescence spectrum Methods 0.000 description 1
- 238000010438 heat treatment Methods 0.000 description 1
- 238000001027 hydrothermal synthesis Methods 0.000 description 1
- 239000012535 impurity Substances 0.000 description 1
- 239000002608 ionic liquid Substances 0.000 description 1
- 229910052751 metal Inorganic materials 0.000 description 1
- 239000002184 metal Substances 0.000 description 1
- 239000002105 nanoparticle Substances 0.000 description 1
- 238000006862 quantum yield reaction Methods 0.000 description 1
- 229910052761 rare earth metal Inorganic materials 0.000 description 1
- 150000002910 rare earth metals Chemical class 0.000 description 1
- 238000002390 rotary evaporation Methods 0.000 description 1
- 239000000523 sample Substances 0.000 description 1
- 239000004065 semiconductor Substances 0.000 description 1
- 238000000926 separation method Methods 0.000 description 1
- 229910052710 silicon Inorganic materials 0.000 description 1
- 239000010703 silicon Substances 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 231100000331 toxic Toxicity 0.000 description 1
- 230000002588 toxic effect Effects 0.000 description 1
Landscapes
- Carbon And Carbon Compounds (AREA)
- Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
Abstract
Description
Claims (18)
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201410844156.8A CN104560036B (zh) | 2014-12-30 | 2014-12-30 | 一种以蜂蜜为碳源的碳量子点荧光标记材料及其制备方法和应用 |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201410844156.8A CN104560036B (zh) | 2014-12-30 | 2014-12-30 | 一种以蜂蜜为碳源的碳量子点荧光标记材料及其制备方法和应用 |
Publications (2)
Publication Number | Publication Date |
---|---|
CN104560036A CN104560036A (zh) | 2015-04-29 |
CN104560036B true CN104560036B (zh) | 2017-01-18 |
Family
ID=53077127
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN201410844156.8A Active CN104560036B (zh) | 2014-12-30 | 2014-12-30 | 一种以蜂蜜为碳源的碳量子点荧光标记材料及其制备方法和应用 |
Country Status (1)
Country | Link |
---|---|
CN (1) | CN104560036B (zh) |
Families Citing this family (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN105241854A (zh) * | 2015-09-10 | 2016-01-13 | 天津大学 | 一种利用荧光碳量子点检测三价铁离子的方法 |
CN106698393A (zh) * | 2016-12-05 | 2017-05-24 | 广西师范学院 | 橘子皮合成水溶性碳量子点的方法 |
CN106892418B (zh) * | 2017-01-18 | 2019-03-29 | 云南大学 | 一种用豆腐废水制作碳量子点的方法 |
CN108562564B (zh) * | 2018-03-29 | 2021-04-02 | 青岛大学 | 一种用于菊糖酶活度检测的碳量子点及制备方法和应用 |
Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN103387219A (zh) * | 2013-07-22 | 2013-11-13 | 苏州大学 | 一种微波辐射制备水溶性多色碳量子点的方法 |
-
2014
- 2014-12-30 CN CN201410844156.8A patent/CN104560036B/zh active Active
Patent Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN103387219A (zh) * | 2013-07-22 | 2013-11-13 | 苏州大学 | 一种微波辐射制备水溶性多色碳量子点的方法 |
Non-Patent Citations (2)
Title |
---|
Novelandgreensynthesisofhigh-fluorescentcarbondotsoriginated fromhoneyforsensingandimaging;Xiaoming Yang 等;《Biosensors andBioelectronics》;20140430;第60卷;292–298 * |
Surface Passivation of Carbon Nanoparticles with Branched Macromolecules Influences Near Infrared Bioimaging;Lina Wu 等;《Theranostics》;20130814;第3卷(第9期);677-686 * |
Also Published As
Publication number | Publication date |
---|---|
CN104560036A (zh) | 2015-04-29 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
Liu et al. | Carbon dots: synthesis, formation mechanism, fluorescence origin and sensing applications | |
Yuan et al. | Multicolor fluorescent graphene quantum dots colorimetrically responsive to all-pH and a wide temperature range | |
Rao et al. | Efficient synthesis of highly fluorescent carbon dots by microreactor method and their application in Fe3+ ion detection | |
CN106753352B (zh) | 一种氮掺杂的荧光碳量子点及其制备方法和应用 | |
CN108485097B (zh) | 一种长余辉发光纳米粒子标记的微塑料及制备方法与应用 | |
Jia et al. | Stable Cu nanoclusters: from an aggregation-induced emission mechanism to biosensing and catalytic applications | |
CN104560036B (zh) | 一种以蜂蜜为碳源的碳量子点荧光标记材料及其制备方法和应用 | |
Wang et al. | Luminescent properties of milk carbon dots and their sulphur and nitrogen doped analogues | |
CN105670633B (zh) | 一种微通道反应器连续制备量子点的方法 | |
JP2018532686A (ja) | 酸素含有量が異なるグラフェン量子ドットの製造方法、グラフェン量子ドット、及び蛍光材料 | |
Zhou et al. | Study and comparison on purification methods of multicolor emission carbon dots | |
CN110643360B (zh) | 一种耐水抗热的钙钛矿纳米晶及其制备方法和应用 | |
Ullal et al. | Separation and purification of fluorescent carbon dots–an unmet challenge | |
CN104560035A (zh) | 一种以柑橘皮为碳源的碳量子点荧光标记材料及其制备方法和应用 | |
JP7294671B2 (ja) | 発光性粒子の製造方法、発光性粒子およびバイオイメージング材料 | |
CN114456806B (zh) | 可识别钯离子的近红外荧光纳米探针及其制备方法和应用 | |
Bian et al. | Functionalized-tryptophan stabilized fluorescent Ag nanoclusters: synthesis and its application as Hg2+ ions sensor | |
Xu et al. | Solvothermal synthesis and luminescence properties of yttrium aluminum garnet monodispersed crystallites with well-developed faces | |
CN108689922A (zh) | 一种有机-无机杂化荧光材料双(2-氨基-4-甲基吡啶)四溴化锰金属盐合成方法 | |
CN109179377B (zh) | 一种疏水性荧光碳点的制备方法 | |
CN101787278A (zh) | 水溶性荧光碳纳米粒子的热解合成方法 | |
CN104555984B (zh) | 一种以鸡蛋清为碳源的碳量子点荧光标记材料及其制备方法和应用 | |
CN109133061A (zh) | 一种类石墨烯量子点的制备方法 | |
Nuñez et al. | Uniform Poly (acrylic acid)‐Functionalized Lanthanide‐Doped LaVO4 Nanophosphors with High Colloidal Stability and Biocompatibility | |
CN107794035B (zh) | 一种聚硅氧烷改性碳量子点的合成方法 |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
C06 | Publication | ||
PB01 | Publication | ||
C10 | Entry into substantive examination | ||
SE01 | Entry into force of request for substantive examination | ||
C14 | Grant of patent or utility model | ||
GR01 | Patent grant | ||
TR01 | Transfer of patent right |
Effective date of registration: 20220124 Address after: Room 320, floor 3, building 49, yard 2, Yuanmingyuan West Road, Haidian District, Beijing 100193 Patentee after: Beijing Zhongnong taste detection technology Co.,Ltd. Address before: 100193 Building 1, Scientific Research Institute of agricultural products processing, Academy of Agricultural Sciences, No. 2, Yuanmingyuan West Road, Haidian District, Beijing Patentee before: INSTITUTE OF FOOD SCIENCE AND TECHNOLOGY, CHINESE ACADEMY OF AGRICULTURAL SCIENCES |
|
TR01 | Transfer of patent right | ||
EE01 | Entry into force of recordation of patent licensing contract |
Application publication date: 20150429 Assignee: Yantai Weixi Food Technology Co.,Ltd. Assignor: Beijing Zhongnong taste detection technology Co.,Ltd. Contract record no.: X2023110000049 Denomination of invention: A Carbon Quantum Dot Fluorescence Labeling Material Using Honey as a Carbon Source and Its Preparation Method and Application Granted publication date: 20170118 License type: Common License Record date: 20230327 Application publication date: 20150429 Assignee: Yantai Leguai Food Co.,Ltd. Assignor: Beijing Zhongnong taste detection technology Co.,Ltd. Contract record no.: X2023110000050 Denomination of invention: A Carbon Quantum Dot Fluorescence Labeling Material Using Honey as a Carbon Source and Its Preparation Method and Application Granted publication date: 20170118 License type: Common License Record date: 20230327 |
|
EE01 | Entry into force of recordation of patent licensing contract | ||
EE01 | Entry into force of recordation of patent licensing contract |
Application publication date: 20150429 Assignee: Yantai Jiuda Agricultural Technology Co.,Ltd. Assignor: Beijing Zhongnong taste detection technology Co.,Ltd. Contract record no.: X2023110000052 Denomination of invention: A Carbon Quantum Dot Fluorescence Labeling Material Using Honey as a Carbon Source and Its Preparation Method and Application Granted publication date: 20170118 License type: Common License Record date: 20230329 Application publication date: 20150429 Assignee: Yantai Zhengwei Food Co.,Ltd. Assignor: Beijing Zhongnong taste detection technology Co.,Ltd. Contract record no.: X2023110000051 Denomination of invention: A Carbon Quantum Dot Fluorescence Labeling Material Using Honey as a Carbon Source and Its Preparation Method and Application Granted publication date: 20170118 License type: Common License Record date: 20230329 |
|
EE01 | Entry into force of recordation of patent licensing contract |