CN104547852B - A kind of pharmaceutical composition for treating hepatopathy - Google Patents
A kind of pharmaceutical composition for treating hepatopathy Download PDFInfo
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- CN104547852B CN104547852B CN201410527990.4A CN201410527990A CN104547852B CN 104547852 B CN104547852 B CN 104547852B CN 201410527990 A CN201410527990 A CN 201410527990A CN 104547852 B CN104547852 B CN 104547852B
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Abstract
The invention discloses a kind of pharmaceutical composition for treating hepatopathy, and it is prepared by radix bupleuri, Fructus meliae toosendan, rhizoma cyperi, the banksia rose, corydalis tuber, the red sage root, turtle shell, Radix Codonopsis, the Radix Astragali, Poria cocos, the bighead atractylodes rhizome, radix glycyrrhizae, fructus amomi, Amomum cardamomum, radish seed, Fructus Hordei Germinatus by certain weight ratio.Pharmaceutical composition of the present invention is applied to treatment and the auxiliary treatment of hepatic diseases and uncomfortable liver area symptom.
Description
Technical field
The invention belongs to pharmaceutical compounding techniques field, especially, is related to a kind of pharmaceutical composition for treating hepatopathy.
Background technology
Liver is glandula digestive maximum in human body, is the central station of substance in vivo energetic supersession.It is estimated that sent out in liver
Raw chemical reaction has more than 500 kinds.Its secretion of bile first, helps digest diet；Its Amino acid synthesis albumen absorption
Matter supplies our human body energies, and let us can lustily complete darg；It can be stored and the fat in burner body
Fat, control our bodily form；It is the depot organ of liposoluble vitamin；It can also aoxidize, reduce, the poison in decomposer
Element, it is the maximum removing toxic substances organ of human body.It is demonstrated experimentally that even if animal gives corresponding treatment after liver is extractd completely, at most
Also can only survive individual hour more than 50, this explanation liver is an essential vitals of the activity of sustaining life.
Common hepatopathy has hepatitis, hepatic sclerosis, primary carcinoma of liver etc., and hepatitis is mainly based on chronic hepatitis, by teiology
It is divided into not clear slow of chronic viral hepatitis, oneself immunity hepatitis, drug toxicity hepatitis, genetic disease and other reasons
Property hepatitis.And virus hepatitis is most commonly seen with hepatitis B, hepatitis B is a kind of pandemic infection disease, global according to statistics
The number of hepatitis B surface antigen is carried more than 2.8 hundred million, China is the district occurred frequently of hepatitis B, has the chronic hepatitis B of existing disease at present about
30000000 people, the annual country dies from liver cirrhosis due to hbv, and person has 400,000 people.
The performance of hepatopathy is that very obscure, most prominent symptom is exactly lassitude and weak and do not feel like eating.Common sympton has swollen
Pain is uncomfortable, nausea, detests greasy, turgor or has jaundice after food, dry, stool is dry or half congealed, and urine is yellow, or has low fever, giddy
Tinnitus, sallow complexion are simple and unadorned etc..If hepatic sclerosis, in addition to the clinical manifestation for having hepatitis, also ascites, vena epigastrica are bent
Open, anasarca, oliguria, liver palms, spider angioma, severe patient is also possible to massive haemorrhage.
Hepatopathy species can be divided into viral liver disease and Non-viral liver disease according to pathogenesis.
Viral liver disease：Be as caused by a variety of different hepatitis viruses one group with liver do harm to based on infectious disease, according to disease
Original learns diagnosis, at least 5 kinds of hepatitis viruse, i.e. first, second, third, fourth, HEV, causes first, second, third, fourth, penta respectively
Type virus hepatitis.
Non-viral liver disease includes following several：
AML：It is due to the hepar damnification disease caused by long-term heavy drinking (being addicted to drink).
Medicine or poisonous substance hepatopathy：Toxic hepatitis is by chemical toxicant (such as phosphorus, arsenic, carbon tetrachloride), medicine or life
Hepatitis or caused hepatic disease caused by thing toxin.
Pathobolism hepatopathy：In vivo to the bad caused hepatopathy of certain material metabolism.
Fatty liver disease：Refer to due to the excessive lesion of fat accumulation in liver cell caused by a variety of causes.Cause liver thin
The fat content increase of born of the same parents, possible cause have excessive drinking, diabetes, the too high, overweight of blood fat etc..
The medicine or pharmaceutical composition of a variety for the treatment of hepatopathys in the prior art be present, its shortcoming is the scope for being applicable hepatopathy
Narrower, therapeutic effect does not protrude, and side effect is more etc..
The content of the invention
The invention provides a kind of pharmaceutical composition for treating hepatopathy, and specifically, it presses the weight ratio by the following raw material
It is prepared：
Radix bupleuri 25-30 Fructus meliae toosendan 10-15 rhizoma cyperi 15-20 banksia rose 10-15 corydalis tuber 15-20 red sage root 20-30 turtle shell 20-30 parties
Join the raw wheats of 20-30 Radix Astragali 20-25 Poria cocos 15-20 bighead atractylodes rhizome 10-15 radix glycyrrhizae 5-10 fructus amomi 15-20 Amomum cardamomum 10-15 radish seeds 15-25
Bud 15-30
Preferably, the Poria cocos 20 of 30 Fructus meliae toosendan of radix bupleuri, 15 rhizoma cyperi, 15 banksia rose, 15 corydalis tuber, 15 red sage root, 20 turtle shell, 30 Radix Codonopsis, 20 Radix Astragali 20
The Fructus Hordei Germinatus 30 of 15 radish seed of the bighead atractylodes rhizome 15 radix glycyrrhizae, 10 fructus amomi, 15 Amomum cardamomum 25
The preparation method of pharmaceutical composition of the present invention can be prepared into conventional agent for the raw material is crushed
Type.
Especially, the raw material can be ground into the smalls (such as fineness by No. 5 sieves) of electuary, be mixed to form punching
Agent.
The usage of pharmaceutical composition of the present invention is often takes 10 grams, and sooner or later after meal, boiling water is taken after mixing it with water, visible treatment in 15 days or so
Effect, to consolidate drug effect, and prevents pathology from recurring, and takes medicine at least three months.
The primary efficacy of pharmaceutical composition of the present invention is：Soothing the liver dissolving stasis, replenishes qi to invigorate the spleen.
Pharmaceutical composition of the present invention cures mainly：The hypochondriac pain of liver depression blood stasis.The distending pain in hypochondrium, connect gastral cavity abdomen bitterly, often because emotional factors add
Weight, deficiency of food belch, spiritlessness and weakness, sallow complexion, loose watery stool, pulse condition string is thin or side of body rib shouting pain, fixed pain, enters nyctalgia very,
Side of body rib Huo Jian Disorder blocks, darkish complexion, purplish tongue, deep and hesitant pulse.
The side's of system principle：We are set for liver depression blood stasis, and irritability is lost to be reached in bar, are hindered in side of body network, therefore the distending pain in hypochondrium, the change of feelings will
It is close with obstruction of the circulation of vital energy junction relationship, therefore pain, often because feelings will increases and decreases, liver-qi perversion easily violates taste, therefore hypochondriac pain connects gastral cavity abdomen, deficiency of food belch,
Spiritlessness and weakness, sallow complexion, loose watery stool, pulse condition string carefully for stagnation of liver-QI with deficiency of the spleen as；
With the passing of time liver depression, qi depression to blood stasis, causes hemostasis to be at a stop, numbness resistance side of body network, therefore hypochondriac pain pain in fixed position, enters nyctalgia very, the stasis of blood as pierced
Knot is stagnated, and is accumulated in the course of time and is not dissipated, then Jian Cheng Disorder blocks, darkish complexion, purplish tongue, deep and hesitant pulse, belongs to the sign stopped in hemostasis.
Radix bupleuri, Fructus meliae toosendan, rhizoma cyperi, the analgesic of banksia rose dispersing stagnated hepatoqi in side, corydalis tuber, the red sage root, turtle shell promoting blood circulation, softening hard masses dissipate
Knot, Radix Codonopsis, the Radix Astragali, the bighead atractylodes rhizome, Poria cocos, radix glycyrrhizae replenish qi to invigorate the spleen, the prosperous then blood of gas, and stagnation resolvation is without hindering just, fructus amomi, Amomum cardamomum, radish
Son, Fructus Hordei Germinatus dampness elimination are amusing and helped digestion, and each medicine shares, and soothing the liver dissolving stasis, softening and resolving hard mass, replenishes qi to invigorate the spleen, all card self-healing.
Pharmaceutical composition of the present invention is mainly used in virus B hepatitis, the third type viral hepatitis, AML, medicine
Property hepatopathy, hepatic sclerosis, primary carcinoma of liver (no transfer, without ascites, portal vein without Tumor thrombus person), after primary carcinoma of liver interventional procedure
Auxiliary treatment, card category obstruction of the circulation of vital energy blood stasis person.Clinical common sympton is weak, anorexia, uncomfortable liver area or pain, abdominal distension, insomnia,
Low-heat.Physical examination meeting color is greyish black, icteric sclera, can there is spider angioma and liver palms.Hepatomegaly, quality is medium or hard, has tenderness and kowtows
Bitterly.There is splenomegaly more.The common serum transaminase of laboratory examination, mark of hepatitis virus thing, bilirubin, alpha-fetoprotein rise, serum
Albumin reduces, and globulin rise, prolonged prothrombin, Serological testing can have anaemia, leucocyte and decrease of platelet,
Hepatitis type B virus serologic marker thing and Hcv thing are often positive.The common hepatomegaly of ultrasonoscopy or
Reduce, splenomegaly, portal hypertension, cancer substance dark space or light blob.It is equal to take the upper disease of pharmaceutical composition of the present invention 15 days or so
Can substantially it mitigate.
Embodiment
Embodiment 1
The bighead atractylodes rhizome of 20 Poria cocos of radix bupleuri 25 Fructus meliae toosendan, 10 rhizoma cyperi, 15 banksia rose, 10 corydalis tuber, 15 red sage root, 20 turtle shell, 20 Radix Codonopsis, 20 Radix Astragali 15
The Fructus Hordei Germinatus 15 of 10 radix glycyrrhizae, 5 fructus amomi, 15 Amomum cardamomum, 10 radish seed 15
Prepare raw material by above weight proportion, each raw material is ground into smalls, is mixed to form electuary, wrapped by often taking 10 grams
Dress.
Embodiment 2
15 corydalis tuber of radix bupleuri 30 Fructus meliae toosendan, 15 rhizoma cyperi, 20 banksia rose, the 20 grams of red sage root 30 turtle shell, 30 Radix Codonopsis, 30 Radix Astragali, 25 Poria cocos 20 are white
The Fructus Hordei Germinatus 30 of 15 radish seed of art 15 radix glycyrrhizae, 10 fructus amomi, 20 Amomum cardamomum 25
Prepare raw material by above weight proportion, each raw material is ground into smalls, is mixed to form electuary, wrapped by often taking 10 grams
Dress.
Embodiment 3
The bighead atractylodes rhizome 15 of 20 Poria cocos of radix bupleuri 30 Fructus meliae toosendan, 15 rhizoma cyperi, 15 banksia rose, 15 corydalis tuber, 15 red sage root, 20 turtle shell, 30 Radix Codonopsis, 20 Radix Astragali 20
The Fructus Hordei Germinatus 30 of 15 radish seed of radix glycyrrhizae 10 fructus amomi, 15 Amomum cardamomum 25
Prepare raw material by above weight proportion, each raw material is ground into smalls, is mixed to form electuary, wrapped by often taking 10 grams
Dress.
Embodiment 4
13 corydalis tuber of radix bupleuri 28 Fructus meliae toosendan, 12 rhizoma cyperi, 18 banksia rose, the 18 grams of red sage root 25 turtle shell, 25 Radix Codonopsis, 25 Radix Astragali, 22 Poria cocos 17 are white
The Fructus Hordei Germinatus 18 of 12 radish seed of art 13 radix glycyrrhizae, 8 fructus amomi, 18 Amomum cardamomum 20
Prepare raw material by above weight proportion, each raw material is ground into smalls, is mixed to form electuary, wrapped by often taking 10 grams
Dress.
Embodiment 5：Effect experiment data
2000 to 2013 to 550 virus hepatitis, AML, DILD, hepatic sclerosis, primary
Liver cancer card category obstruction of the circulation of vital energy blood stasis person, observation treatment is carried out using pharmaceutical composition of the present invention.
It is as follows to observe result：
Case selection
550 hepatopaths, male 365, women 185, -35 years old 16 years old 195, -50 years old 36 years old 275,50 years old
The above 80,550 hepatopaths have that different degrees of complexion is greyish black, abdominal distension gasteremphraxis, hepatalgia, and nausea, diet is reduced.
Become thin, weak, jaundice, hot eyes is puckery, yellow urine, pruitus, insomnia, hepatosplenomegaly, the visible transaminase rise of auxiliary examination, hepatitis
Virus marker thing is positive, and alpha-fetoprotein rise, total bilirubin increase, and albumin, cholinesterase, blood platelet reduce.
Observation of curative effect
Criterion of therapeutical effect
Cure：Sings and symptoms is wholly absent, and labour capacity is recovered, liver function, mark of hepatitis virus thing, alpha-fetoprotein, liver
Courage color ultrasound recovers normal.
It is effective：Most of sings and symptoms disappears after treatment, and labour capacity significantly improves, and mark of hepatitis virus thing part turns
The moon, liver function, alpha-fetoprotein abnormal index are down or up, the visible liver and spleen retraction of liver and spleen color ultrasound.
It is invalid：Clinical symptoms, sign and auxiliary examination are identical with before treatment or aggravate.
As a result：
Counted by above-mentioned standard：412 are cured, effective 104, invalid 34, total effective rate 93.8%, the course for the treatment of is most long by 6
Year, it is most short 3 months.
Case enumerates：
Mr. Wang, male, 65 years old, retired worker, private prosecution started urine Huang before 2 years, without obvious inducement, initial micro- Huang, and several weeks
Color aggravates afterwards, belch, and nausea, mesh is yellow, no vomiting, virus hepatitis is diagnosed as after inspection, through traditional Chinese and western medicine antiviral agent treatment
Without significant curative effect, start to take pharmaceutical composition of the present invention, symptom is relieved after continuously taking 15 days, every after 30 days
The index of virus hepatitis returns to normal range (NR), continuous medication 4 months, is checked after half a year, every biochemical indicator is equal
In normal range (NR).
Peng so-and-so, female, 45 years old, supermarket office worker, patient because with slight schizophrenia therefore long-term use of Clozapine, go out
Now detest oil, receive the symptom such as difference, abdominal distension, check and find that liver function bilirubin and transaminase are too high, confirm as drug induced hepatic injury.Make
Treated with pharmaceutical composition of the present invention, associated conditions mitigate after continuously taking 10 days, and the state of mind takes a turn for the better, and takes three weeks diseases
Shape realizes good control, continuously takes and carries out liver function test after two months, and all indexs recover normal, continue to take 1 month,
Consolidate curative effect, do not occur apparent side effect.
Zhao, man, 56 years old, there is weak, hepatalgia, loss of appetite in company clerk, long-term alcohol, and with nausea,
The symptoms such as mesh Huang, find hepatomegaly, ascites after inspection, indices prompt for alcoholic cirrhosis.Take medicine group of the present invention
Compound is treated, and after taking medicine 4 weeks, weak phenomenon substantially mitigates, and the hepatalgia imagination mitigates, and ascites is reduced, diet increase, after
Continuous medication 12 weeks, ascites disappears, and complexion recovers normal, and diet is normal, nausea disappears, and occasionally there is pain hepatic region, and hepatomegaly reduces.
Claims (2)
1. a kind of pharmaceutical composition for treating hepatopathy, it is prepared by the following raw material by the weight ratio：
Radix bupleuri 25-30 Fructus meliae toosendan 10-15 rhizoma cyperi 15-20 banksia rose 10-15 corydalis tuber 15-20 red sage root 20-30 turtle shell 20-30 Radix Codonopsis
20-30 Radix Astragali 20-25 Poria cocos 15-20 bighead atractylodes rhizome 10-15 radix glycyrrhizae 5-10 fructus amomi 15-20 Amomum cardamomum 10-15 radish seed 15-25 Fructus Hordei Germinatus
15-30。
2. a kind of pharmaceutical composition for the treatment of hepatopathy according to claim 1, wherein raw material weight proportioning of soup processed are：
The radix glycyrrhizae of 20 bighead atractylodes rhizome of radix bupleuri 30 Fructus meliae toosendan, 15 rhizoma cyperi, 15 banksia rose, 15 corydalis tuber, 15 red sage root, 20 turtle shell, 30 Radix Codonopsis, 20 Radix Astragali, 20 Poria cocos 15
The Fructus Hordei Germinatus 30 of 10 fructus amomi, 15 Amomum cardamomum, 15 radish seed 25.
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| Application Number | Priority Date | Filing Date | Title |
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| CN201410527990.4A CN104547852B (en) | 2014-09-26 | 2014-09-26 | A kind of pharmaceutical composition for treating hepatopathy |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410527990.4A CN104547852B (en) | 2014-09-26 | 2014-09-26 | A kind of pharmaceutical composition for treating hepatopathy |
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| CN104547852B true CN104547852B (en) | 2018-03-06 |
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Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101152394A (en) * | 2007-09-29 | 2008-04-02 | 李英 | Traditional Chinese medicine for treating chronic active hepatitis |
| CN101357219A (en) * | 2008-09-04 | 2009-02-04 | 兰州佛慈制药股份有限公司 | Medicine for treating chronic hepatitis b |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20130032427A (en) * | 2011-09-23 | 2013-04-02 | 최종원 | Extract of herbal mixture and phamaceutical composition for treating hbv/hcv infection and hepatocirrhosis and the method for preparing the same |
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Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101152394A (en) * | 2007-09-29 | 2008-04-02 | 李英 | Traditional Chinese medicine for treating chronic active hepatitis |
| CN101357219A (en) * | 2008-09-04 | 2009-02-04 | 兰州佛慈制药股份有限公司 | Medicine for treating chronic hepatitis b |
Non-Patent Citations (1)
| Title |
|---|
| 贾兴鲁老中医治疗肝病经验介绍;李更新等;《新中医》;20040930;第36卷(第9期);第15-16页，尤其是第16页右栏第1段第6-10行 * |
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