CN104547710A - Medicament for treating infantile thrush - Google Patents

Medicament for treating infantile thrush Download PDF

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CN104547710A
CN104547710A CN201510031720.9A CN201510031720A CN104547710A CN 104547710 A CN104547710 A CN 104547710A CN 201510031720 A CN201510031720 A CN 201510031720A CN 104547710 A CN104547710 A CN 104547710A
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parts
herba
radix
medicament
rhizoma
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CN104547710B (en
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张希梅
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Li Xuchen
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
    • A61K36/539—Scutellaria (skullcap)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/06—Fungi, e.g. yeasts
    • A61K36/07—Basidiomycota, e.g. Cryptococcus
    • A61K36/076—Poria
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
    • A61K36/287—Chrysanthemum, e.g. daisy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/31—Brassicaceae or Cruciferae (Mustard family), e.g. broccoli, cabbage or kohlrabi
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/39—Convolvulaceae (Morning-glory family), e.g. bindweed
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • A61K36/484—Glycyrrhiza (licorice)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/54—Lauraceae (Laurel family), e.g. cinnamon or sassafras
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/65—Paeoniaceae (Peony family), e.g. Chinese peony
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/71—Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/71—Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
    • A61K36/718—Coptis (goldthread)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/75—Rutaceae (Rue family)
    • A61K36/752—Citrus, e.g. lime, orange or lemon
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/894—Dioscoreaceae (Yam family)
    • A61K36/8945—Dioscorea, e.g. yam, Chinese yam or water yam
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/899—Poaceae or Gramineae (Grass family), e.g. bamboo, corn or sugar cane

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  • Health & Medical Sciences (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
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Abstract

The invention relates to a medicament for treating infantile thrush. The medicament is prepared from the following substances in parts by weight: 1-10 parts of scutellaria baicalensis, 1-10 parts of corn stigma, 1-5 parts of nutmeg, 5-10 parts of chrysanthemum, 1-10 parts of poria cocos, 1-5 parts of camphor roots, 1-10 parts of Chinese yams, 1-5 parts of coptis chinensis, 1-5 parts of lysimachia foenum-graecum, 1-10 parts of shaddock leaves, 1-5 parts of liquorice, 1-10 parts of herba sidae rhombifoliae, 1-10 parts of ivy glorybind herb roots, 1-5 parts of borneol, 1-5 parts of Chinese herbaceous peony, 1-5 parts of Xylosma peel, 1-5 parts of passion fruits and 1-5 parts of shepherd's purse. The medicament provided by the invention is remarkable in effect and safe for treating infantile thrush and is worth clinically applying and popularizing.

Description

A kind of medicament for the treatment of infantile thrush
Technical field
The present invention relates to field of medicaments, relate in particular to a kind of medicament for the treatment of infantile thrush.
Background technology
Infantile thrush has another name called moniliasis white mouth, reads bacterium disease in vain, is caused by fungal infection, and with a kind of department of pediatrics common oral disease that oral cavity, tongue to be abound with white scales be main clinical characteristics, the infant within 2 years old is the most common, and easily recurs.When the low neonate of immune function, malnutrition, diarrhoea or life-time service broad ectrum antibiotic, hormone etc. make infant resistance lower, namely the mucosa in oral cavity may infect.Not easily find when infecting slight, also obviously do not keenly feel, if but treat not in time, impaired mucosa can constantly expand, spread to pharyngeal, tonsil, gingiva etc., severe patient can spread to esophagus, bronchus, causes monilial esophagitis or pulmonary candidiasis, occurs breathing, dysphagia, minority can concurrent chronic mucosa dermatocandidiasis, affect lifetime immunity function, even can other bacteriological infection of secondary, cause septicemia.
Modal Therapeutic Method is that nystatin or other antifungal antibiotics are applied in affected part clinically at present.But antibiotic life-time service or improper use can produce the side effect such as vomiting, diarrhoea, and easily form Drug resistance, the digestive system of infant and immune system are had a negative impact.
Summary of the invention
The object of this invention is to provide a kind of Chinese drugs agentia for the treatment of infantile thrush.
In order to realize object of the present invention, the invention provides a kind of medicament for the treatment of infantile thrush, it is made up of the material of following weight portion: Radix Scutellariae 1-10 part, Stigma Maydis 1-10 part, nutmeg 1-5 part, Flos Chrysanthemi 5-10 part, Poria 1-10 part, Radix Cinnamomi Camphorae 1-5 part, Rhizoma Dioscoreae 1-10 part, Rhizoma Coptidis 1-5 part, Herba Lysimachiae foenum-graeci 1-5 part, Folium Citri grandis 1-10 part, Radix Glycyrrhizae 1-5 part, Herba Sidae Rhombifoliae 1-10 part, Rhizoma Calystegiae Hederaceae (Herba Calystegiae Hederaceae) 1-10 part, Borneolum Syntheticum 1-5 part, Radix Paeoniae 1-5 part, Cortex Xylosmae japonici 1-5 part, Passiflora edulis sims 1-5 part, Herba Capsellae 1-5 part.
Preferably, the medicament for the treatment of infantile thrush of the present invention is made up of the material of following weight portion: Radix Scutellariae 5 parts, Stigma Maydis 6 parts, nutmeg 2 parts, Flos Chrysanthemi 6 parts, 6 parts, Poria, Radix Cinnamomi Camphorae 2 parts, Rhizoma Dioscoreae 6 parts, Rhizoma Coptidis 2 parts, Herba Lysimachiae foenum-graeci 3 parts, Folium Citri grandis 8 parts, 2 parts, Radix Glycyrrhizae, Herba Sidae Rhombifoliae 3 parts, Rhizoma Calystegiae Hederaceae (Herba Calystegiae Hederaceae) 5 parts, Borneolum Syntheticum 3 parts, Radix Paeoniae 2 parts, Cortex Xylosmae japonici 3 parts, Passiflora edulis sims 4 parts, 3 parts, Herba Capsellae.
More preferably, described medicament can be tablet, dispersible tablet, capsule, soft capsule or powder.
The present invention also provides the purposes of compositions in the medicine of preparation treatment infantile thrush, and described compositions is made up of the material of following weight portion: Radix Scutellariae 1-10 part, Stigma Maydis 1-10 part, nutmeg 1-5 part, Flos Chrysanthemi 5-10 part, Poria 1-10 part, Radix Cinnamomi Camphorae 1-5 part, Rhizoma Dioscoreae 1-10 part, Rhizoma Coptidis 1-5 part, Herba Lysimachiae foenum-graeci 1-5 part, Folium Citri grandis 1-10 part, Radix Glycyrrhizae 1-5 part, Herba Sidae Rhombifoliae 1-10 part, Rhizoma Calystegiae Hederaceae (Herba Calystegiae Hederaceae) 1-10 part, Borneolum Syntheticum 1-5 part, Radix Paeoniae 1-5 part, Cortex Xylosmae japonici 1-5 part, Passiflora edulis sims 1-5 part, Herba Capsellae 1-5 part.
Preferably, described compositions is made up of the material of following weight portion: Radix Scutellariae 5 parts, Stigma Maydis 6 parts, nutmeg 2 parts, Flos Chrysanthemi 6 parts, 6 parts, Poria, Radix Cinnamomi Camphorae 2 parts, Rhizoma Dioscoreae 6 parts, Rhizoma Coptidis 2 parts, Herba Lysimachiae foenum-graeci 3 parts, Folium Citri grandis 8 parts, 2 parts, Radix Glycyrrhizae, Herba Sidae Rhombifoliae 3 parts, Rhizoma Calystegiae Hederaceae (Herba Calystegiae Hederaceae) 5 parts, Borneolum Syntheticum 3 parts, Radix Paeoniae 2 parts, Cortex Xylosmae japonici 3 parts, Passiflora edulis sims 4 parts, 3 parts, Herba Capsellae.
More preferably, described medicine can be tablet, dispersible tablet, capsule, soft capsule or powder.
In the present compositions, Herba Sidae Rhombifoliae, Rhizoma Calystegiae Hederaceae (Herba Calystegiae Hederaceae) are monarch drug; Radix Scutellariae, Stigma Maydis, nutmeg, Flos Chrysanthemi, Poria, Radix Cinnamomi Camphorae are ministerial drug; Rhizoma Dioscoreae, Rhizoma Coptidis, Herba Lysimachiae foenum-graeci, Folium Citri grandis, Borneolum Syntheticum, Radix Paeoniae, Cortex Xylosmae japonici, Passiflora edulis sims, Herba Capsellae are adjuvant drug, and Radix Glycyrrhizae coordinating the actions of various ingredients in a prescription, for making medicine.
Each component synergism of medicament of the present invention, has effect of clearing away heat-fire, dampness removing toxic substances, simultaneously cold relieving warming the stomach, slow liver lung moistening, treatment infantile thrush Be very effective and safer, clinic application and promoting.
Detailed description of the invention
The present invention is further illustrated below by embodiment.Those skilled in the art it is intended that, embodiments of the invention are for illustration of the present invention instead of limitation of the present invention.The simple modification that essence according to the present invention is carried out all belongs to the present invention's scope required for protection.Unless otherwise stated, the percent in the present invention is percetage by weight.
The preparation of embodiment 1 powder of the present invention
Take Radix Scutellariae 500 grams, Stigma Maydis 600 grams, nutmeg 200 grams, Flos Chrysanthemi 600 grams, 600 grams, Poria, Radix Cinnamomi Camphorae 200 grams, Rhizoma Dioscoreae 600 grams, Rhizoma Coptidis 200 grams, Herba Lysimachiae foenum-graeci 300 grams, Folium Citri grandis 800 grams, 200 grams, Radix Glycyrrhizae, Herba Sidae Rhombifoliae 300 grams, Rhizoma Calystegiae Hederaceae (Herba Calystegiae Hederaceae) 500 grams, Borneolum Syntheticum 300 grams, Radix Paeoniae 200 grams, Cortex Xylosmae japonici 300 grams, Passiflora edulis sims 400 grams, 300 grams, Herba Capsellae, pulverize and grind end, cross 100 mesh sieves, be dispensed in 100 bags, obtain described powder.
The clinical data of test example powder of the present invention
1, this group of physical data thrush infant totally 160 examples, all make a definite diagnosis in conjunction with clinical symptoms and lab testing.Wherein minimum 9 months of the age, maximum 4 years old, average 2.5 years old.Clinical symptoms: the white plates of white point-like or likeness in form milk block appears in both sides, oral cavity mucosa or tongue or maxillary, and not easily wipe, after peeling off, mucosa is rubescent, and part infant has the performances such as anorexia, dysphoria or grade fever.All infants are divided into experimental group and matched group at random according to age, clinical symptoms etc.Wherein experimental group 90 example, matched group 70 example, two groups of there was no significant differences in physical data, have comparability.
2, the powder that Therapeutic Method experimental group is prepared with embodiment 1 is treated, and matched group is treated with SHANGLIAOHOUFENG SAN (purchased from Guangdong Jiaying Pharmaceutical Co., Ltd).During medication, fix infant head, a hand-held spatula opening pushes down tongue body, fully exposes oral mucosa focus; Another hands cotton swab dips medicamental pulverata, coats affected part gently, every day 3 times.Suckling or drinking-water is not given, in order to avoid wash out the medicine in oral cavity during treatment.Experimental group uses 1 bag of powder in embodiment 1 at every turn.Matched group sprays 0.5 gram at every turn.
3, the block inflammatory thing of the white ziega sampling point on effect assessment oral mucosa disappears, and clinical malaise symptoms disappears, and laboratory detection result is shown as feminine gender.
4, result
Through treatment, two groups of infants are all fully recovered, and cure rate all reaches 100%, and treatments period does not find obvious untoward reaction.Two groups of cure time statistics are as shown in table 1, and as can be seen from Table 1, the evaluation of experimental group cure time is significantly better than matched group, and two groups of differences have significantly learns meaning (P<0.05).
Table 1 liang group therapeutic effect statistics
Group Number of cases Recovery from illness in 1-2 days Recovery from illness in 3-4 days Within more than 5 days, fully recover
Experimental group 90 69(76.6％)* 18(20.0％)* 3(3.3％)*
Matched group 70 26(37.1％) 32(45.7％) 12(17.2％)
Note: compare * P<0.05 between group, has remarkable significant difference.

Claims (6)

1. treat the medicament of infantile thrush for one kind, it is characterized in that, be made up of the material of following weight portion: Radix Scutellariae 1-10 part, Stigma Maydis 1-10 part, nutmeg 1-5 part, Flos Chrysanthemi 5-10 part, Poria 1-10 part, Radix Cinnamomi Camphorae 1-5 part, Rhizoma Dioscoreae 1-10 part, Rhizoma Coptidis 1-5 part, Herba Lysimachiae foenum-graeci 1-5 part, Folium Citri grandis 1-10 part, Radix Glycyrrhizae 1-5 part, Herba Sidae Rhombifoliae 1-10 part, Rhizoma Calystegiae Hederaceae (Herba Calystegiae Hederaceae) 1-10 part, Borneolum Syntheticum 1-5 part, Radix Paeoniae 1-5 part, Cortex Xylosmae japonici 1-5 part, Passiflora edulis sims 1-5 part, Herba Capsellae 1-5 part.
2. the medicament for the treatment of infantile thrush according to claim 1, it is characterized in that, be made up of the material of following weight portion: Radix Scutellariae 5 parts, Stigma Maydis 6 parts, nutmeg 2 parts, Flos Chrysanthemi 6 parts, 6 parts, Poria, Radix Cinnamomi Camphorae 2 parts, Rhizoma Dioscoreae 6 parts, Rhizoma Coptidis 2 parts, Herba Lysimachiae foenum-graeci 3 parts, Folium Citri grandis 8 parts, 2 parts, Radix Glycyrrhizae, Herba Sidae Rhombifoliae 3 parts, Rhizoma Calystegiae Hederaceae (Herba Calystegiae Hederaceae) 5 parts, Borneolum Syntheticum 3 parts, Radix Paeoniae 2 parts, Cortex Xylosmae japonici 3 parts, Passiflora edulis sims 4 parts, 3 parts, Herba Capsellae.
3. the medicament for the treatment of infantile thrush according to claim 1 and 2, is characterized in that, described medicament can be tablet, dispersible tablet, capsule, soft capsule or powder.
4. the purposes of compositions in the medicament of preparation treatment infantile thrush, it is characterized in that, described compositions is made up of the material of following weight portion: Radix Scutellariae 1-10 part, Stigma Maydis 1-10 part, nutmeg 1-5 part, Flos Chrysanthemi 5-10 part, Poria 1-10 part, Radix Cinnamomi Camphorae 1-5 part, Rhizoma Dioscoreae 1-10 part, Rhizoma Coptidis 1-5 part, Herba Lysimachiae foenum-graeci 1-5 part, Folium Citri grandis 1-10 part, Radix Glycyrrhizae 1-5 part, Herba Sidae Rhombifoliae 1-10 part, Rhizoma Calystegiae Hederaceae (Herba Calystegiae Hederaceae) 1-10 part, Borneolum Syntheticum 1-5 part, Radix Paeoniae 1-5 part, Cortex Xylosmae japonici 1-5 part, Passiflora edulis sims 1-5 part, Herba Capsellae 1-5 part.
5. purposes according to claim 4, it is characterized in that, described compositions is made up of the material of following weight portion: Radix Scutellariae 5 parts, Stigma Maydis 6 parts, nutmeg 2 parts, Flos Chrysanthemi 6 parts, 6 parts, Poria, Radix Cinnamomi Camphorae 2 parts, Rhizoma Dioscoreae 6 parts, Rhizoma Coptidis 2 parts, Herba Lysimachiae foenum-graeci 3 parts, Folium Citri grandis 8 parts, 2 parts, Radix Glycyrrhizae, Herba Sidae Rhombifoliae 3 parts, Rhizoma Calystegiae Hederaceae (Herba Calystegiae Hederaceae) 5 parts, Borneolum Syntheticum 3 parts, Radix Paeoniae 2 parts, Cortex Xylosmae japonici 3 parts, Passiflora edulis sims 4 parts, 3 parts, Herba Capsellae.
6. the purposes according to claim 4 or 5, is characterized in that, described medicament can be tablet, dispersible tablet, capsule, soft capsule or powder.
CN201510031720.9A 2015-01-25 2015-01-25 A kind of medicament for the treatment of infantile thrush Expired - Fee Related CN104547710B (en)

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CN114712402A (en) * 2020-12-22 2022-07-08 山西好医生药业有限公司 Composition for treating infantile thrush and preparation method thereof

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