CN104547347A - Pure traditional Chinese medicine composition for treating cow endometritis - Google Patents
Pure traditional Chinese medicine composition for treating cow endometritis Download PDFInfo
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Abstract
The invention discloses a pure traditional Chinese medicine composition for treating cow endometritis. The pure traditional Chinese medicine composition is prepared by mixing the following components in parts by weight: notopterygium root, seed of feather cockscomb, the bark of ash, cyrtomium fortunei, the root of Chinese pulsatilla, Chinese lobelia, grifola, monkshood, clove, dalbergia wood, myrrh, herba lycopi, rhizoma acori graminei, sea-buckthorn, polygonum multiflorum and borax. The preparation method comprises the following steps: totally mixing the traditional Chinese medicines together according to the ratio, adding water in an amount of 10 times, decocting for three times, wherein the decoction time is 2 hours each time, combining the decoction, standing over the night, filtering, taking the supernatant, performing reduced pressure concentration under the condition of 0.08MPa and 80 DEG C until the relative density is 1.05-1.10 (50 DEG C), cooling, adding ethanol so as to reach the alcohol content of 60 percent, standing for 48 hours, filtering, taking the supernatant, recovering the ethanol until alcohol flavor is avoided, adding 2g of potassium sorbate, adding water to regulate until the content of medicinal materials is 1g/mL, filtering, filling, sterilizing at the temperature of 115 DEG C for 30 minutes, and packaging, thereby obtaining the product. The traditional Chinese medicine is taken with water twice per day, 800ml of the medicine is taken each time, and a course of treatment refers to three days.
Description
Technical field
The present invention relates to a kind of pure Chinese medicine composition for the treatment of cow endometritis, belong to field of veterinary.
Background technology
Cow endometritis Producing reason has following several respects: one is that sanitary condition is too poor, cow pudendum and ambient contamination during production and do not have sterilization to clean out; Two be practise midwifery or peel off afterbirth time, the utensil of contact etc. sterilization not strict; Three is that after producing, placenta retention corruption is decomposed, and lochia is stagnated; Four is infectious disease, as the reasons such as trichomoniasis, leptospira, infectious bovine rhinotrachetis, viral diarrhea all can cause endometrium infection in puerperal.In addition, hydrometra, severe dilation, injury of birth canal, low blood calcium, Parturient Environment are dirty etc. can cause uterine infection.When ambient temperature is higher or on the low side, passive protective physical fitness reduces and the improper sickness rate of primary disease that all can make of feeding and management uprises.
Chinese medicine experienced by the succession of several thousand, is the product of long-term clinical practice of Chinese medicine.It is taken at nature and easily obtains, and selectivity numerous in variety is large, and after Preparation process, drug effect is different, and toxicity is few safe and effective, and the advantages such as dosage form is various make it in production practices, have the position do not replaced.
Summary of the invention
The object of the invention is the pure Chinese medicine composition providing a kind of reasonable recipe, easy to prepare, evident in efficacy, effective treatment cow endometritis.
Implementation of the present invention is as follows for achieving the above object: a kind of pure Chinese medicine composition for the treatment of cow endometritis, by following component by weight mixed preparing form: Rhizoma Et Radix Notopterygii 10 ~ 25 parts, Semen Celosiae 15 ~ 30 parts, Cortex Fraxini 10 ~ 25 parts, Rhizoma Osmundae 15 ~ 25 parts, the Radix Pulsatillae 15 ~ 25 parts, Herba Lobeliae Chinensis 10 ~ 25 parts, Polyporus 15 ~ 25 parts, Radix Aconiti Lateralis Preparata 15 ~ 30 parts, Flos Caryophylli 10 ~ 25 parts, Lignum Dalbergiae Odoriferae 10 ~ 25 parts, Myrrha 5 ~ 10 parts, Herba Lycopi 10 ~ 30 parts, Rhizoma Acori Graminei 15 ~ 25 parts, Fructus Hippophae 15 ~ 30 parts, Radix Polygoni Multiflori 15 ~ 25 parts, Borax 5 ~ 10 parts.
Get above-mentioned Chinese medicine total in proportion all to mix, add 10 times of water gagings, decoct 3 times, each 2h, merges decoction liquor, hold over night, cross leaching supernatant, decompression (0.08MP, 80 DEG C) concentrates, to relative density 1.05 ~ 1.10 (50 DEG C), let cool, add ethanol, make alcohol content to 60%, place 48h, filter, leaching supernatant, reclaim ethanol extremely without ethanol taste, add 2g potassium sorbate, add water and be adjusted to medical material content 1g/mL, filter, fill, sterilizing (115 DEG C, 30 minutes) is packed and be get final product.
Rhizoma Osmundae TLC distinguish: get Chinese medicine composition and be equivalent to Rhizoma Osmundae 0.5g, evaporate to dryness, adds cyclohexane extraction 20ml, supersound process 30 minutes, filters, gets subsequent filtrate 10ml, be concentrated into 5ml, as need testing solution.Separately get Rhizoma Dryopteris Crassirhizomatis control medicinal material 0.5g, be made in the same way of control medicinal material solution.Test according to thin layer chromatography (Chinese Pharmacopoeia 10 editions annex VIB), draw need testing solution 4 μ l, control medicinal material solution 5 μ l, put respectively on same silica gel g thin-layer plate, with normal hexane-chloroform-methanol (30: 15: 1) for developing solvent, lamellae to put in expansion cylinder presaturation 2 hours, launches, exhibition is apart from more than 8cm, take out, spray the Diluted Alcohol solution with 0.3% fast blue BB salt immediately, place 1 hour at 40 DEG C.In test sample chromatograph, on the position corresponding to control medicinal material chromatograph, the speckle of aobvious same color.
Radix Aconiti Lateralis Preparata TLC distinguish: get Chinese medicine composition and be equivalent to Radix Aconiti Lateralis Preparata 2g, add ammonia solution 3ml moistening, add diethyl ether 25ml, supersound process 30 minutes, filters. and filtrate volatilizes, and the residue 0.5ml that adds methylene chloride makes dissolving, as need testing solution.Separately get Benzoylmesaconine reference substance, benzoyl aconine reference substance, benzoyl hypo-aconine reference substance, add isopropyl alcohol one dichloromethane (1: 1) mixed solution and make every 1ml respectively containing the mixed solution of 1mg, product solution (monoester alkaloid) in contrast.Get mesaconitine reference substance, hypaconitine reference substance, aconitine reference substance again, add the cruel dichloromethane of isopropyl (1: 1) mixed solution and make every 1rnl respectively containing the mixed solution of 1mg, product solution (diester-type alkaloids) in contrast.Test according to thin layer chromatography (annex VIB), draw need testing solution and each 5 ~ 10 μ l of reference substance solution, put respectively on same silica gel g thin-layer plate, with n-hexane-ethyl acetate-methanol (6.4: 3.6: 1) for developing solvent, put in the ammonia saturated with vapor expansion cylinder of 20 minutes, launch, take out, dry, spray with rare bismuth potassium iodide test solution.In test sample chromatograph.Radix Aconiti Lateralis Preparata on the position corresponding with aconitine reference substance chromatograph to mesaconitine reference substance, hypaconitine reference substance, the speckle of aobvious same color; Radix Aconiti Lateralis Preparata or Radix Aconiti Lateralis Preparata on the position corresponding to Benzoylmesaconine reference substance, benzoyl aconine reference substance, benzoyl hypo-aconine reference substance chromatograph, the speckle of aobvious same color.
Fructus Hippophae TLC distinguish: the preparation of need testing solution is got Chinese medicine composition and is equivalent to Fructus Hippophae 0.5g, evaporate to dryness, put in tool plug conical flask, precision adds people's ethanol 50ml, weighed weight, reflux 1 hour, lets cool, more weighed weight, supply the weight of less loss with ethanol, shake up, filter.Precision measures subsequent filtrate 25ml, puts in tool plug conical flask, adds hydrochloric acid 3.5ml, and in 75 DEG C of water-baths, heating hydrolysis 1 hour, cools immediately, is transferred in 50ml measuring bottle. use ethanol in proper amount washing container.Washing liquid is incorporated in same measuring bottle, adds ethanol to scale, shakes up, and filters, gets subsequent filtrate, get 30ml, be concentrated into about 5ml, add water 25ml, extracts 2 times by ethyl acetate, each 20ml, combined ethyl acetate liquid, evaporate to dryness, residue adds methanol 1ml makes dissolving, as need testing solution.Separately get different Fructus rhamni (Rhamnus davurica Pall.) rope reference substance, Quercetin reference substance, add methanol and make every 1ml respectively containing the mixed solution of 1mg, product solution in contrast.Test according to " thin layer chromatography touchstone operation sequence " (Chinese Pharmacopoeia 10 editions annex VIB), draw each 2 μ l of above-mentioned two kinds of solution, put respectively and contain on silica gel g thin-layer plate prepared by 3% sodium acetate solution in same, with toluene-ethyl acetate-formic acid (5: 2: 1) for developing solvent, launch, take out, dry, spray, with aluminum chloride test solution, is inspected under putting ultra-violet lamp (365nm).In test sample chromatograph, on the position corresponding to reference substance chromatograph, the fluorescence speckle of aobvious same color.
Radix Polygoni Multiflori TLC distinguish: get Chinese medicine composition and be equivalent to Radix Polygoni Multiflori 0.25g, evaporate to dryness, add ethanol 50ml, reflux 1 hour, filter, filtrate is concentrated into 3ml, as need testing solution.Separately get Radix Polygoni Multiflori control medicinal material 0.25g, be made in the same way of control medicinal material solution.Test according to " thin layer chromatography touchstone operation sequence " (annex VIB), suct and state two kinds of each 2 μ l of solution, put respectively in same with sodium carboxymethyl cellulose be adhesive silica gel H lamellae on make into strips, with chloroform-methanol (7: 3) for developing solvent, exhibition is to about 3.5cm, take out, dry, then with chloroform-methanol (20: 1) for developing solvent, exhibition is to about 7cm, take out, dry, inspect under putting ultra-violet lamp (365nm).In test sample chromatograph, on the position corresponding to control medicinal material chromatograph, the fluorescence speckle of aobvious same color.
Polyporus assay: measure according to high performance liquid chromatography (annex VID).Chromatographic condition and system suitability take octadecylsilane chemically bonded silica as filler; Take methanol as mobile phase; Determined wavelength is 283nm.Number of theoretical plate calculates should be not less than 5000 by ergosterol peak.The preparation of reference substance solution gets ergosterol reference substance in right amount, accurately weighed, adds methanol and makes the solution of every 1ml containing 50 μ g, to obtain final product.The preparation of need testing solution is got Chinese medicine composition and is equivalent to Polyporus and is about 0.5g, evaporate to dryness, puts in tool plug conical flask, precision adds methanol 10ml, weighed weight, supersound process (power 220W, frequency 50kHz) 1 hour, let cool, more weighed weight, the weight of less loss is supplied with methanol, shake up, filter, get subsequent filtrate, to obtain final product.Algoscopy is accurate respectively draws reference substance solution and each 20 μ l of need testing solution, injection liquid chromatography, measures, to obtain final product.This product is pressed dry product and is calculated, containing ergosterol (C
28h
44o) 0.070% must not be less than.
Myrrha assay: get this product 20g (removing impurity), measures according to determination of volatile oil method (Chinese Pharmacopoeia 10 editions annex XD second methods).This product must not be less than 4.0% (ml/g) containing the natural Myrrha of volatile oil, and gum opoponax must not be less than 2.0% (ml/g).
Rhizoma Acori Graminei assay: measure according to determination of volatile oil method (annex XD).This product must not be less than 1.0% (ml/g) containing volatile oil.
The medicinal property of each component is as follows:
Rhizoma Et Radix Notopterygii: induce sweat cold expelling, expelling wind and dampness, pain relieving.For dry rhizome and the root of samphire Rhizoma Et Radix Notopterygii Notopterygiumincisum Ting ex H.T.Chang or Radix et Rhizoma Notopterygii NotopterygiumforbesiiBoiss..Spring, Qiu Erji excavate, and removing fibrous root and silt, dry.Section, raw use.
Semen Celosiae: clearing away heat-fire, improving acuity of vision and removing nebula.For the dry mature seed of amaranthaceous plant Herba Celosiae argenteae Celosia argentea L..Tap plant during fruit maturation in autumn or win fruit ear, drying, collecting seed, removing impurity.Raw use.
Cortex Fraxini: heat clearing and damp drying, astringent therapy dysentery relieving, leukorrhagia stopping, improving eyesight.For dry branch skin or the dried bark of sweet-scented osmanthus plant fraxinus rhynchophylla Hance FraxinusrhynchophyllaHance, Chinese ash F.chinensisRoxb., sharp leaf Chinese ash F.szaboanaLingelsh. or place post Chinese ash F.stylosaLingelsh..Spring, Qiu Erji strip, and dry.Raw use.
Rhizoma Osmundae: heat-clearing and toxic substances removing, cooling blood for hemostasis, parasite killing.For the dry rhizome of the band petiole base of Dryopteridaceae plant dryopteris crassirhizoma DryopteriscrassirhizomaNakai.Autumn excavates, and cleans, and removing petiole and fibrous root, dry.Section is raw to be used or parch to black use.
The Radix Pulsatillae: heat-clearing and toxic substances removing, eliminating pathogenic heat from blood to cure dysentery.For the dry root of cohosh Radix Pulsatillae Pulsatillachinensis (Bge.) Regel.Spring, Qiu Erji excavate, and except defoliation and residual scape and fibrous root, retain the white fine hair of root head, dry.Shave, raw use.
Herba Lobeliae Chinensis: heat-clearing and toxic substances removing, inducing diuresis to remove edema.For the dry herb of Campanulaceae Herba Lobeliae Chinensis Lobelia chinensisLour..Summer gathers, and pulls up herb, and removing impurity, cutting, dries.Using fresh herb or raw use.
Polyporus: promoting diuresis to eliminate damp pathogen.For the dry sclerotia of On Polyporaceae Polyporus Polyporusumbellatus (Pers.) Fries.Parasitize on the root of Betula, maple, Querci Mongolicae.Spring, Qiu Erji excavate, and remove silt, dry.Section is used as medicine, raw use.
Radix Aconiti Lateralis Preparata: recuperating depleted YANG and rescuing the patient from collapse, mends fire supporing yang, dispersing cold for relieving pain.For the processed goods of the daughter root of cohosh Aconitum carmichjaelii Debx. Aconitum carmichaeliDebx..Late June excavated to early August, and removing parent root, fibrous root and silt, practise and claim " mud Radix Aconiti Lateralis Preparata ".Processing methods is Radix Aconiti Lateralis Preparata, Radix Aconiti Lateralis Preparata (Radix Aconiti Lateralis Preparata), Radix Aconiti Lateralis Preparata, RADIX ACONITI LATERALIS PREPARATA, gun tab.
Flos Caryophylli: warming middle-JIAO to send down the adverse QI, dispersing cold for relieving pain, warming the kidney to activate YANG.For the dry flower of plant clove of myrtaceae Eugenia caryophyllataThunb..Practise and claim Flos Caryophylli.Usually in JIUYUE to March next year, gather when alabastrum is red by green turn, dry.Raw use.
Lignum Dalbergiae Odoriferae: removing stasis to stop bleeding, regulating QI to relieve pain.For the dry duramen of leguminous plant Lignum Dalbergiae Odoriferae wingceltis DalbergiaodoriferaT.Chen trunk and root.The whole year all can gather.Removing sapwood, is split into fritter, dries in the shade, raw use.
Myrrha: promoting blood circulation and stopping pain, detumescence and promoting granulation.For the oleo-gum-resin that olive subject plant myrrh CommiphoramyrrhaEngl. or other congener skin zones ooze out.Wild or cultivation, in February November to next year, gathers and oozes out by bark crack the oleo-gum-resin becoming the hard block of rufous in air.Pick decontamination, break into the raw use of fragment, take orally and make use more, fry or processed with vinegar.
Herba Lycopi: promoting blood flow to regulate menstruation, inducing diuresis to remove edema.For the dry aerial parts of labiate hair leaf lycopus lucidus LycopuslucidusTurcz.Regel.Wild.Summer, autumn two tap when season, stem and leaf was luxuriant, dry.Removing impurity earth, runs through, cutting, raw use after dry.
Rhizoma Acori Graminei: refreshment of having one's ideas straightened out, removing dampness to restore normal function of the stomach, beneficial will of allaying excitement.For the dry rhizome of acorus gramineus araceae plant AcorustatarinowiiSchott, autumn, season in winter two excavate, and removing fibrous root and silt, dry.Raw use.
Fructus Hippophae: strengthening the spleen to promote digestion, eliminating phlegm and stopping cough, blood circulation promoting and blood stasis dispelling.For the mature fruit of Elaeangnaceae plant Fructus Hippophae Hippophaerhamnoides L..Wild or cultivation.During autumn and winter two season fruit maturation or sky freezing hard after gather, removing impurity, dries or dries after steaming, and rawly uses.
Radix Polygoni Multiflori: system is used: enrich and benefit essence and blood.For the tuber of polygonum multiflorum thunb PolygonummultiflorumThunb..Dig when stem and leaf is withered or before next year non-rudiment after autumn and get its tuber.To prune two ends, clean, section, dries or micro-baking, claims Radix Polygoni Multiflori; If mix steaming with Semen sojae atricolor liquor, after solarization, become black, claim Radix Polygoni Multiflori Preparata.
Borax: external heat-clearing and toxic substances removing.For the Ore of natural minerals Borax, through the crystalline solid of refining refinement.Excavate between general 8 ~ November.Removing impurity, smashs to pieces, gives birth to or forges use.Have another name called Borax, Borax.
Detailed description of the invention
Embodiment 1: Rhizoma Et Radix Notopterygii 100g, Semen Celosiae 150g, Cortex Fraxini 100g part, Rhizoma Osmundae 150g, Radix Pulsatillae 150g, Herba Lobeliae Chinensis 100g, Polyporus 150g, Radix Aconiti Lateralis Preparata 150g, Flos Caryophylli 100g, Lignum Dalbergiae Odoriferae 100g, Myrrha 50g, Herba Lycopi 100g, Rhizoma Acori Graminei 150g, Fructus Hippophae 150g, Radix Polygoni Multiflori 150g, Borax 50g.
Get above-mentioned Chinese medicine total in proportion all to mix, add 10 times of water gagings, decoct 3 times, each 2h, merges decoction liquor, hold over night, cross leaching supernatant, decompression (0.08MP, 80 DEG C) concentrates, to relative density 1.05 ~ 1.10 (50 DEG C), let cool, add ethanol, make alcohol content to 60%, place 48h, filter, leaching supernatant, reclaim ethanol extremely without ethanol taste, add 2g potassium sorbate, add water and be adjusted to medical material content 1g/mL, filter, fill, sterilizing (115 DEG C, 30 minutes) is packed and be get final product.
Embodiment 2: Rhizoma Et Radix Notopterygii 200g, Semen Celosiae 250g, Cortex Fraxini 200g part, Rhizoma Osmundae 250g, Radix Pulsatillae 250g, Herba Lobeliae Chinensis 200g, Polyporus 250g, Radix Aconiti Lateralis Preparata 250g, Flos Caryophylli 200g, Lignum Dalbergiae Odoriferae 200g, Myrrha 80g, Herba Lycopi 200g, Rhizoma Acori Graminei 250g, Fructus Hippophae 250g, Radix Polygoni Multiflori 250g, Borax 80g.
Get above-mentioned Chinese medicine total in proportion all to mix, add 10 times of water gagings, decoct 3 times, each 2h, merges decoction liquor, hold over night, cross leaching supernatant, decompression (0.08MP, 80 DEG C) concentrates, to relative density 1.05 ~ 1.10 (50 DEG C), let cool, add ethanol, make alcohol content to 60%, place 48h, filter, leaching supernatant, reclaim ethanol extremely without ethanol taste, add 2g potassium sorbate, add water and be adjusted to medical material content 1g/mL, filter, fill, sterilizing (115 DEG C, 30 minutes) is packed and be get final product.
Embodiment 3: Rhizoma Et Radix Notopterygii 250g, Semen Celosiae 300g, Cortex Fraxini 250g part, Rhizoma Osmundae 300g, Radix Pulsatillae 300g, Herba Lobeliae Chinensis 250g, Polyporus 300g, Radix Aconiti Lateralis Preparata 300g, Flos Caryophylli 250g, Lignum Dalbergiae Odoriferae 250g, Myrrha 100g, Herba Lycopi 250g, Rhizoma Acori Graminei 300g, Fructus Hippophae 300g, Radix Polygoni Multiflori 300g, Borax 100g.
Get above-mentioned Chinese medicine total in proportion all to mix, add 10 times of water gagings, decoct 3 times, each 2h, merges decoction liquor, hold over night, cross leaching supernatant, decompression (0.08MP, 80 DEG C) concentrates, to relative density 1.05 ~ 1.10 (50 DEG C), let cool, add ethanol, make alcohol content to 60%, place 48h, filter, leaching supernatant, reclaim ethanol extremely without ethanol taste, add 2g potassium sorbate, add water and be adjusted to medical material content 1g/mL, filter, fill, sterilizing (115 DEG C, 30 minutes) is packed and be get final product.
Embodiment 4: mice auricular concha Edema Test
Get the ICR mice 40 of body weight 20 ~ 30g, be divided into Chinese medicine composition high dose group (1g crude drug/ml) at random, middle dosage group (0.5g crude drug/ml), low dose group (0.25g crude drug/ml) and saline control group, often organize 10, press 0.2ml/10g body weight gavage respectively, connect filling 4 days, 0.5h after last perfusion, inside and outside every mouse right ear, both sides coating dimethylbenzene is about 0.1ml, cause mice auricular concha edema, left ear is not painted with normal ear, mice is put to death after 4h, mice two ear is cut respectively, be that the card punch of 3mm lays auricle at the same position of auricular concha with diameter, accurately weigh.Represent ear swelling degree with the difference of left and right two auricle weight, and calculate inhibitory rate of intumesce, inhibitory rate of intumesce (%)=(matched group ear swelling degree-medication group ear swelling degree)/matched group ear swelling degree × 100%.In result display, dosage group and high dose group are remarkable with matched group comparing difference, and the mice auricular concha edema that namely middle dosage group and high dose group xylol cause has obvious inhibitory action.This test demonstrates this Chinese medicine composition high dose group and middle dosage group obviously can alleviate mice ear degree caused by dimethylbenzene, has obvious antiinflammatory action.
The impact (X ± S, n=10, mg) of table 1 Chinese medicine composition xylol induced mice ear swelling
| Group | Dosage (g/kg) | Ear swelling degree | Suppression ratio (%) |
| Matched group | - | 0.71±0.021 | - |
| Low dose group | 5 | 0.58±0.087 | 18.31 |
| Middle dosage group | 10 | 0.41±0.076 * | 42.25 |
| High dose group | 20 | 0.36±0.05 * | 49.30 |
Embodiment 5: mice granuloma induced by implantation of cotton pellets is tested
ICR mice, body weight 25 ~ 29g, mice group and dosage regimen the same.With the pentobarbital sodium anesthetized mice of 7.5mg/ml, after cropping sterilization, respectively implant the sterilizing cotton balls (containing penicillin 800u, streptomycin 650u) a piece of 10mg at groin place, left and right, sew up.Gastric infusion from the same day of performing the operation, connected to 6 days, and after last administration, 24h puts to death mice, take out cotton balls, reject fatty tissue, retain cellulose exudate, the cotton balls often organizing taking-up is divided with filter paper pressure water purification respectively, dries 3 hours in juxtaposition 60 DEG C of constant temperature blast drying ovens, precise weighing.The weight claimed is deducted cotton balls weight and namely obtains granulomatous weight.In result display, dosage group and high dose group are remarkable with matched group comparing difference, and namely middle dosage group and high dose group obviously can suppress the hypertrophy of granulation tissue.This test demonstrates the weight that Chinese medicine composition high dose group and middle dosage group obviously can alleviate granuloma induced by implantation of cotton pellets, has obvious antiinflammatory action.
Table 2 Chinese medicine composition is on the impact (X ± S, n=10, mg) of mice cott on pellet-induced granuloma formation
| Group | Dosage (g/kg) | Granulation tissue weight | Suppression ratio (%) |
| Matched group | - | 27.6±10.45 | - |
| Low dose group | 5 | 26.9±9.70 | 2.54 |
| Middle dosage group | 10 | 23.1±10.04 * | 16.30 |
| High dose group | 20 | 21.8±9.38 * | 21.01 |
Embodiment 6: sick cattle 10 is cattle farm, one, Langfang, puerperal 5 ~ 10d, sick beefsteak yellow-white or reddish purulent secretion, taste stench.Be endometritis and without injury of birth canal, systemic disease and the other diseases affecting Reproductive Performance through Disease Diagnosis of Veterinary.Gavaging 2 every day, each 800ml, 3 days is a course for the treatment of.Statistical result showed, cure rate and pregnancy rate of once inseminating are respectively 90% and 80%, and namely the therapeutic effect of this Chinese medicine composition to cow endometritis is better.
Cure: discharge from the inviscid or sticky purulent secretion of vaginal orifice.Open examination per vagina with prolapsus appliance, vagina, vagina portion and cervical orifice place are all without rheuminess thing, non-when oestrusing, and cervical orifice is closed, pinkiness (without congested); Examination per rectum, the contraction in uterus, size and quality recover normal; Stop treating in latter 30 days and recover normally to oestrus, and mucus is normal, can carry out artificial fertilization.Various lab testing is all without exception.
Effective: to discharge from the inviscid or sticky purulent secretion of vaginal orifice.Open examination per vagina with prolapsus appliance, vagina, vagina portion and cervical orifice place are all without rheuminess thing, non-when oestrusing, and cervical orifice is closed, pinkiness (without congested).Examination per rectum, the contraction in uterus, size and quality recover normal substantially; Stop, in latter 30 days for the treatment of, not recovering normally to oestrus, although or recover mucus still abnormal (be mixed with pus wadding or limpid not or poor toughness) of oestrusing, can not artificial fertilization be carried out.Lab testing, various index is close to normal.
Effective: clinical symptoms is obviously improved.Vaginal orifice still has rheuminess thing to discharge, but output obviously reduces, and purulent secretion ratio reduces.Open examination per vagina with prolapsus appliance, vagina, cervical orifice still visible a small amount of rheuminess thing exist; Non-when oestrusing, cervical orifice is still opened a business and congested; Examination per rectum, the contractile response in uterus increases, body of uterus and cornua uteri diminish, improved texture.Lab testing, most of index is close to normal.
Invalid: every inspection and clinical symptoms have no and take a turn for the better or increase the weight of to some extent.Lab testing, various index is without significant change.
Table 3 Chinese medicine composition is to the therapeutic effect comparative result of cow endometritis
Claims (1)
1. treat a pure Chinese medicine composition for cow endometritis, by following component by weight mixed preparing form: Rhizoma Et Radix Notopterygii 10 ~ 25 parts, Semen Celosiae 15 ~ 30 parts, Cortex Fraxini 10 ~ 25 parts, Rhizoma Osmundae 15 ~ 25 parts, the Radix Pulsatillae 15 ~ 25 parts, Herba Lobeliae Chinensis 10 ~ 25 parts, Polyporus 15 ~ 25 parts, Radix Aconiti Lateralis Preparata 15 ~ 30 parts, Flos Caryophylli 10 ~ 25 parts, Lignum Dalbergiae Odoriferae 10 ~ 25 parts, Myrrha 5 ~ 10 parts, Herba Lycopi 10 ~ 30 parts, Rhizoma Acori Graminei 15 ~ 25 parts, Fructus Hippophae 15 ~ 30 parts, Radix Polygoni Multiflori 15 ~ 25 parts, Borax 5 ~ 10 parts.
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| CN112051351A (en) * | 2020-08-28 | 2020-12-08 | 康美药业股份有限公司 | Thin-layer chromatography identification method for Heishui tablets |
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Non-Patent Citations (1)
| Title |
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| 南京中医药大学编著: "《中药大辞典》", 31 March 2006, 上海科学技术出版社 * |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112051351A (en) * | 2020-08-28 | 2020-12-08 | 康美药业股份有限公司 | Thin-layer chromatography identification method for Heishui tablets |
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