CN104547251A - Navel paste for treatment of acute enteritis and preparation method thereof - Google Patents

Abstract

The invention provides a navel paste for the treatment of acute enteritis and a preparation method thereof. The navel paste is prepared from the following raw materials in parts by weight: 20-25 parts of herba artemisiae, 16-20 parts of creeping dichondra, 20-30 parts of feverfew, 10-15 parts of melia toosendan, 16-25 parts of fructus mume, 18-26 parts of wild jujubes, 12-16 parts of unprocessed rhizoma pinelliae, 6-8 parts of rhizoma zingiberis, 5-8 parts of pericarpium citri reticulatae, 12-16 parts of radix bupleuri, 12-16 parts of rhizoma atractylodis, 16-25 parts of exocarpium benincasae, 12-16 parts of semen raphani, and 8-10 parts of radix glycyrrhizae. The navel paste disclosed by the invention is simple in preparation method; the navel paste treats an internal illness by external treatment, and is safe in medication; the navel paste is easy to use, and takes effect quickly; and the navel paste can be used for overcoming the defect of increasing the burden of liver and kidney caused by pessimal stimulation of oral drug preparations on gastrointestinal tracts, and avoiding some untoward effects caused after traditional Chinese medicine raw materials containing toxic components are taken.

Description

A kind of umbilicus for the treatment of acute enteritis pastes and preparation method

Technical field

The invention belongs to external umbilicus and paste drug world, be specifically related to a kind of umbilicus for the treatment of acute enteritis and paste and preparation method.

Background technology

Acute enteritis is commonly encountered diseases, the frequently-occurring disease of summer and autumn.Many caused by the infected by microbes such as antibacterial and virus, its performance is mainly stomachache, diarrhoea, Nausea and vomiting, heating etc., and severe patient can cause de-water and rock-soil coupling, shock etc.Patient shows as Nausea and vomiting formerly more, continues to suffer from diarrhoea, every day 3 ~ 5 times, even several 10 times not etc., stool in water sample, buff or band green, stench, can with symptoms such as abdominal colic, heating, systemic pain.In Chinese medicine, there is no the name of disease of acute enteritis, according to the main clinical manifestation of acute gastroenteritis, such disease belong to the traditional Chinese medical science vomiting, suffer from diarrhoea, have loose bowels, cholera, dry cholera, the disease category such as the depletion syndrome.Its cause of disease has experiences seasonal pathogen, injury due to diet, disorder of emotion and internal organs weakness etc., but Chief is spleen-stomach dysfunction and gastrointestinal dysfunction.

Bad life, dietary habit, insobriety etc., very easily cause the generation of acute gastroenteritis, and can recurrent exerbation, often accompany Behavioral disturbances, cause quality of life decline, need Long-term taking medicine or repeatedly go to a doctor, cause a large amount of medical resource consumption, patient economy burden heavy, except partial symptoms comparatively the lighter by except cured substance, severe patient need be performed a surgical operation treatment, affect the absorption of food digestion and nutrition in human body, other damage and diseases can be caused in vivo, serious harm human health simultaneously.

At present, be main for the treatment of such disease mainly with Antibiotics medicine, but antibiotics has certain toxic and side effects more, long-time application can cause enteric flora disturbance, and easily produces drug resistance.The traditional Chinese medical science conventional with " strengthening vital QI to eliminate pathogenic factors " for the rule for the treatment of, but do not filter out effective typical medicaments for a long time as main body to carry out compatibility, existing prescription curative effect all difficulty reaches promising result.

Therefore, by scientific composition, screening a kind of Chinese medicine of effective treatment enteritis, fast quick-recovery digestive system function, is the important topic will researched and solved at present.

Summary of the invention

The present invention is directed to prior art above shortcomings, a kind of umbilicus for the treatment of acute enteritis is provided to paste, inner disease outer treat, drug safety, easy to use, instant effect, solve because oral drug preparation produces pessimal stimulation to gastrointestinal tract simultaneously and increase the weight of the drawback of Liver and kidney burden, some untoward reaction that the toxic component avoided because existing in raw material of Chinese medicine medicine causes after taking.

The preparation method that the umbilicus that present invention also offers above-mentioned treatment acute enteritis pastes.

A kind of umbilicus for the treatment of acute enteritis of the present invention pastes, and is made up: Herba Artemisiae Anomalae 20 ~ 25, Herba Dichodrae 16 ~ 20, Flos Chrysanthemi 20 ~ 30, Herba Solani Lyrati 16 ~ 25, Radix et Caulis Opuntiae Dillenii 18 ~ 26, Fructus Mume 12 ~ 16, the Radix Aucklandiae 6 ~ 8, the Radix Linderae 5 ~ 8, Rhizoma Atractylodis 12 ~ 16, Exocarpium Benincasae 12 ~ 16, Halloysitum Rubrum 16 ~ 25, Flos Caryophylli 12 ~ 16 and Radix Glycyrrhizae 8 ~ 10 of the crude drug of following weight parts.

The preparation method that a kind of umbilicus for the treatment of acute enteritis of the present invention pastes, step comprises:

1) Herba Artemisiae Anomalae of ormal weight is taken, Herba Dichodrae, Flos Chrysanthemi, Herba Solani Lyrati, Radix et Caulis Opuntiae Dillenii, Fructus Mume, the Radix Aucklandiae, the Radix Linderae, Rhizoma Atractylodis, Exocarpium Benincasae, Flos Caryophylli and Radix Glycyrrhizae, cleaning is dried, pulverizing to 80 ~ 90 order, mix homogeneously, the concentration adding medical material gross weight 3 ~ 5 times is the ethanol water sealing immersion 10 ~ 15 days of 80% ~ 90%, period stirs twice, filter, filtering residue adds 95% soak with ethanol 3 ~ 5 h of 2 ~ 3 times, reflux, extract, 1 ~ 2h, cooling is filtered, merging filtrate, evaporate to dryness, add the Halloysitum Rubrum of ormal weight, mixing pulverizing to 30 ~ 40 order, obtain Chinese medicine extract, for subsequent use,

2) the medical dimethyl sulfoxide of 0.5 ~ 0.8 part is taken, the laurocapram of 0.3 ~ 0.6 part, the Borneolum Syntheticum of the menthol of 1 ~ 3 part and 1 ~ 3 part, mix homogeneously, joins in the purified water of 15 ~ 20 parts, is slowly stirred to and is sufficiently uniformly dissolved, obtain penetration enhancer mixed liquor, for subsequent use;

3) Chinese medicine extract 40 ~ 50 parts of step 1) obtained and step 2) the penetration enhancer mixed liquor that obtains, join in the glycerol of 40 ~ 60 parts, stir 20 ~ 30min, ultrasonic 10min, for subsequent use;

4) take the Cera Flava of 30 ~ 50 parts, after dissolving, add in the glycerol of step 3), stir 8 ~ 17min, ultrasonic to mix homogeneously, obtain ointment, for subsequent use;

5) step 4) gained ointment is heated, uniform application on cotton, in 25 ~ 30 DEG C, under humidity 55 ~ 60% condition, leave standstill 2 ~ 3 days, obtain the umbilicus that the present invention treats acute enteritis and paste.

The umbilicus that the present invention treats acute enteritis pastes in preparation method; in adjuvant used, Cera Flava has effect of astringent therapy, granulation promoting, pain relieving, removing toxic substances; glycerol is a kind of extraordinary moisturizing articles for use; for preparing medical ointment and the raw material of skin care ointment; the substrate (adjuvant) adopted in preparation method and penetration enhancer, chemical stabilization, preparation technology is easy, be conducive to umbilicus penetrates and absorbs; especially to skin of umbilicus place without anaphylaxis, more have no side effect.

The umbilicus subsides usage that the present invention treats acute enteritis is simple: external, uses warm water cleaning, dry around umbilical part, tablet is aimed at umbilical part, firm pasting, once-a-day, and a note.

The umbilicus that the present invention treats acute enteritis pastes based on the anti-inflammatory analgetic that gets rid of illness, and is aided with the medicine consolidating and just support, realizes treating both the principal and secondary aspects of a disease, and the property of medicine is gentle, and attack evil taking a tonic or nourishing food to build up one's health and combine, auxiliary vigour, enhancing immunity, pure Chinese medicine formula, has no side effect.Fang Zhong, with Herba Artemisiae Anomalae, Herba Dichodrae, Flos Chrysanthemi, Herba Solani Lyrati, Radix et Caulis Opuntiae Dillenii, Fructus Mume is principal agent, there is easing pain and diminishing inflammation, antibacterial, effect of detumescence, the Radix Aucklandiae, the Radix Linderae, Rhizoma Atractylodis, Exocarpium Benincasae, Halloysitum Rubrum, Flos Caryophylli and Radix Glycyrrhizae are accessory drugs, play clearing away heat-damp and promoting diuresis, warming spleen and stomach for dispelling cold, with middle QI invigorating, heat-clearing and toxic substances removing, improve the effect of the intestines and stomach function, all medicines are harmonious, compatibility is precise and appropriate, play anti-inflammatory analgesic altogether, subduing swelling and detoxicating, effect of the intestines and stomach coordinating, and to digestant object, umbilicus of the present invention is used to paste treatment acute enteritis, and the indigestion symptom caused thus has safety, stable, efficient clinical efficacy, energy relief of symptoms, and reduce palindromia.

Herba Artemisiae Anomalae: bitter, warm, GUIXIN, liver, spleen channel, have hemostasis of curing the wound, removing blood stasis stimulates the menstrual flow, promoting digestion and removing stagnation, and the effect of appetizing of being amusing, can be used for acute icterohepatitis, toothache, chronic tracheitis, stomatitis, pharyngolaryngitis, tonsillitis, nephritis, malaria; Eye conjunctivitis is controlled in external, otitis media, skin infection, eczema, traumatic hemorrhage.

Herba Dichodrae: bitter in the mouth, pungent, cold nature, owner's lung meridian stomach function regulating warp, has the liver protecting and ALT lowering, easing pain and diminishing inflammation, antibacterial, antipyretic function of gallbladder promoting, strengthens immunity and anticancer effect, for hepatitis, cholecystitis, dysentery, oedema due to nephritis, urinary system infection, urinary system calculus, tonsillitis, traumatic injury.

Flos Chrysanthemi: nature and flavor are pungent, sweet, bitter, are slightly cold, returns lung, Liver Channel, has effect of dispelling wind and heat pathogens, suppressing the hyperactive liver improving eyesight, heat-clearing and toxic substances removing, cure mainly anemopyretic cold, fever and headache, conjunctival congestion is dim-sighted, deficiency of the liver and kindey, order is secretly dim-sighted, and dizzy infantile convulsion, controls excessive rising of liver-YANG, has a headache dizzy, kind wind and heat dispersing, purging liver-fire, energy tonifying YIN improving eyesight of holding concurrently, therefore availablely control wind-heat of liver channel, or liver-fire is attacked caused conjunctival congestion and swelling pain, the effect of long memorial wind liver heat removing and eyesight improving altogether, heat-clearing and toxic substances removing, outstanding kind separates furunculosis, therefore availablely controls furuncle swelling toxin.

Herba Solani Lyrati: sweet, bitter, cold, clearing away heat-damp and promoting diuresis, removing toxic substances, detumescence, the function such as anticancer; For cold, fever, oedema due to nephritis, cholecystitis, carbuncle furuncle and phyma poison, the diseases such as rheumatic arthritis, are used for the treatment of various cancer clinically.

Radix et Caulis Opuntiae Dillenii: bitter, cold, enter the heart, lung, stomach three warp, promoting flow of QI and blood, heat-clearing and toxic substances removing, reducing swelling and alleviating pain; Cure mainly heart peratodynia, mass in the abdomen, dysentery, hemorrhoidal bleeding." Guangxi Chinese herbal medicine ": antidiarrheal, controls enteritis, diarrhea." Luchuan book on Chinese herbal medicine ": eliminating inflammation and expelling toxin, evacuation of pus granulation promoting." east, Fujian book on Chinese herbal medicine ": energy blood stasis removing, intestinal detoxication, stomach invigorating, pain relieving, nourishing, relaxing muscles and tendons and activating QI and blood in the collateral, hemostasis of curing the wound.Control hemorrhoidal hamorrhage anal fistula hematochezia, lung abscess, stomachache, traumatic injury.

Fructus Mume: return liver, spleen, lung, large intestine channel, there is the effect improving liver function, Fructus Mume is nutritious, containing protein, fat, carbohydrate, citric acid, malic acid, succinic acid, oleanolic acid sample material and potassium, sitosterol etc., Fructus Mume has contraction gallbladder, promotes buckets of beaten eggs secretion and antianaphylactic effect.

The Radix Aucklandiae: acrid in the mouth, hardship, warm in nature, return spleen, large intestine, tri-jiao channel.Promoting the circulation of QI to relieve pain, warming middle-JIAO for easing the stomach, the invasion by pathogenic cold stagnation of QI, chest and abdomen swelling and pain etc.; Total medicine of gas controlled in " book on Chinese herbal medicine " speech, and stomachgas, the logical motive, to fall lunggas, dispersing liver-energy, fast temper, warming the kidney gas, removing food stagnancy gas, warm cold, along inverse gas, reach table gas, Tongli gas, the unified lower inside and outside all gas with it of pipe, solely pushes away its merit.

The Radix Linderae: warming spleen and stomach for dispelling cold, regulating QI to relieve pain, heart peratodynia, stomachache of vomiting and diarrhoea; Radix Linderae compatibility the Radix Aucklandiaepromoting the circulation of QI to relieve pain cold expelling, is longer than the loose part of the body cavity below the umbilicus, housing the bladder, kidneys and bowels cold-damp of temperature; Radix Aucklandiae promoting the circulation of QI to relieve pain, merit arrogates to oneself row stagnation of QI in spleen and stomach.Two medicine mutual reinforcements between are use, and effect of its cold expelling, circulation of qi promoting, pain relieving is more outstanding.

Rhizoma Atractylodis: acrid in the mouth, hardship, warm in nature, return spleen, stomach, Liver Channel, drying damp and strengthening spleen, expelling wind and cold, improving eyesight, can act on gastrointestinal smooth muscle and realize producing dual regulation to gastrointestinal motility, its acetone extract obviously can promote gastrointestinal motility.

Exocarpium Benincasae: cold nature and sweet in the mouth, light, return spleen, stomach, large intestine, small intestine meridian, there is effect of heat clearing away, diuretic, detumescence, can subside a swelling by clearing away heat and promoting diuresis, be usually used in edema distension, be particularly useful for the diseases such as damp and hot caused dysuria, nutritious contained by Exocarpium Benincasae, containing multiple volatile ingredient, triterpenoid compound, cholesterol derivative, again containing mineral and trace element such as vitamin B1, vitamin C, nicotinic acid, carotene.Exocarpium Benincasae also can treat diabetes, adheres to drink-service Exocarpium Benincasae soup, and " more than three " symptom of diabetics can be made to be significantly improved.

Halloysitum Rubrum: admittedly collapse only something lost, promoting tissue regeneration and ulcer healing; Astringing intestine to stop diarrhea, hemostasis, removing dampness, granulation promoting; Control chronic diarrhea, chronic dysentery, have blood in stool, proctoptosis, seminal emission, metrorrhagia, leukorrhagia, ulcer being unable to heal; " property of medicine opinion ": " tonifying five ZANG-organs void is weary.": " thick the intestines and stomach, dewaters wet for reinforcing the heart blood, granulation promoting meat, receives proctoptosis.": " book on Chinese herbal medicine converges and says " " ooze and cut off the water, dry gas, sore mouth, Gu slippage, antidiarrheal dysentery intestinal Bleach, prohibits metrorrhagia and drench band.”

Flos Caryophylli: warming middle-JIAO, warming the kidney, sending down the abnormal ascending QI; Cure mainly vomiting, regurgitation, trusted subordinate's cold type of pain; " medical center bun want ": " tonifying liver, the profit gate of vitality, go invasion by pathogenic cold, eliminating the pathogens from the lung, loose rheumatism at warming the stomach." " pharmacognosy ": " controlling chronic indigestion, gastrointestinal inflation and uterus colic. "

Radix Glycyrrhizae: with middle QI invigorating, coordinating the actions of various ingredients in a prescription invigorating the spleen and replenishing QI, heat-clearing and toxic substances removing, expelling phlegm for arresting cough, relieving spasm to stop pain, coordinating the actions of various ingredients in a prescription.For weakness of the spleen and stomach, fatigue and weakness, shortness of breath and palpitation, cough with copious phlegm, the anxious pain of gastral cavity abdomen, extremity contraction, carbuncle sore tumefacting virus, cushion toxicity, strong.

A kind of umbilicus for the treatment of acute enteritis of the present invention pastes and preparation method, and relative to prior art, its beneficial effect is:

1) form according to the different qualities of every Chinese medicine and different ratio modulation, formula is unique, and safety of selecting materials is evident in efficacy for acute enteritis;

2) umbilicus administration, adds medical dimethyl sulfoxide, laurocapram, menthol, Borneolum Syntheticum as penetration enhancer, is more conducive to Drug Percutaneous Absorption and plays drug effect in preparation process, convenient and swift, drug safety, easy to use, instant effect, persistent;

3) inner disease outer treat, without oral, do not stimulate harmonization of the stomach blood vessel, solve because oral drug preparation produces pessimal stimulation to gastrointestinal tract simultaneously and increase the weight of the drawback of Liver and kidney burden, some untoward reaction that the toxic component simultaneously avoided because existing in raw material of Chinese medicine medicine causes after taking.

Detailed description of the invention

In order to understand essence of the present invention better, the umbilicus further illustrating treatment acute enteritis below by clinical testing data and specific embodiment pastes and preparation method, and uses the beneficial effect of medicine of the present invention:

Embodiment 1

A kind of umbilicus for the treatment of acute enteritis of the present embodiment pastes, and is made up: Herba Artemisiae Anomalae 22, Herba Dichodrae 17, Flos Chrysanthemi 22, Herba Solani Lyrati 18, Radix et Caulis Opuntiae Dillenii 20, Fructus Mume 14, the Radix Aucklandiae 6, the Radix Linderae 6, Rhizoma Atractylodis 12, Exocarpium Benincasae 15, Halloysitum Rubrum 20, Flos Caryophylli 13 and Radix Glycyrrhizae 9 of the crude drug of following weight parts.

The preparation method that a kind of umbilicus for the treatment of acute enteritis of the present embodiment pastes, step comprises:

1) Herba Artemisiae Anomalae, Herba Dichodrae, Flos Chrysanthemi, Herba Solani Lyrati, Radix et Caulis Opuntiae Dillenii, Fructus Mume, the Radix Aucklandiae, the Radix Linderae, Rhizoma Atractylodis, Exocarpium Benincasae, Flos Caryophylli and Radix Glycyrrhizae is taken by the present embodiment prescription, cleaning is dried, pulverizing to 80 order, mix homogeneously, the concentration adding medical material gross weight 4 times is the ethanol water sealing immersion 15 days of 86%, period stirs twice, and filter, filtering residue adds the 95% soak with ethanol 3h of 3 times, reflux, extract, 2h, cooling is filtered, merging filtrate, evaporate to dryness, add the Halloysitum Rubrum of recipe quantity, mixing pulverizing to 30 order, obtains Chinese medicine extract, for subsequent use;

2) take the medical dimethyl sulfoxide of 0.5g, the laurocapram of 0.3g, the menthol of 2g and the Borneolum Syntheticum of 2g, mix homogeneously, joins in the purified water of 15g, is slowly stirred to and is sufficiently uniformly dissolved, and obtains penetration enhancer mixed liquor, for subsequent use;

3) Chinese medicine extract 45g step 1) obtained and step 2) the penetration enhancer mixed liquor that obtains, join in the glycerol of 45g, stir 30min, ultrasonic 10min, for subsequent use;

4) take the Cera Flava of 35g, after dissolving, add in the glycerol of step 3), stir 15min, ultrasonic to mix homogeneously, obtain ointment, for subsequent use;

5) step 4) gained ointment is heated, uniform application on cotton, in 30 DEG C, under humidity 60% condition, leave standstill 2 days, the umbilicus obtaining the present embodiment treatment acute enteritis pastes.

It is a subsides medicine that the umbilicus of the treatment acute enteritis obtained by the present embodiment step and proportioning pastes.

Embodiment 2

A kind of umbilicus for the treatment of acute enteritis of the present embodiment pastes, and is made up: Herba Artemisiae Anomalae 25, Herba Dichodrae 20, Flos Chrysanthemi 28, Herba Solani Lyrati 22, Radix et Caulis Opuntiae Dillenii 25, Fructus Mume 16, the Radix Aucklandiae 8, the Radix Linderae 8, Rhizoma Atractylodis 16, Exocarpium Benincasae 16, Halloysitum Rubrum 22, Flos Caryophylli 15 and Radix Glycyrrhizae 9 of the crude drug of following weight parts.

Preparation method is with embodiment 1.

Animal experiment study

1, Folium Sennae causes diarrhea of mouse model, mouse model totally 60, and male and female half and half divide equally 4 groups: umbilicus subsides group, CHANGYANNING PIAN group, berberine hydrochloride group, normal saline group at random.

2, on the impact of mice defecation:

Umbilicus subsides group, the umbilicus using embodiment 1 obtained pastes, and 8g crude drug/kg body weight, can delete dose by weight ratio, carries out the observation experiment of mice antidiarrheal, once-a-day, a note.

CHANGYANNING PIAN group, 8g/kg, every day 3 times.

Berberine hydrochloride group, gives Berberine Hydrochloride Tablets solution, 0.70g/kg body weight, every day 3 times.

Normal saline group, gives equal-volume normal saline.

Fasting 12h after successive administration 5 times, after last administration 30min, gavage gives 35% Radix Et Rhizoma Rhei liquid 1ml/20g body weight (Radix Et Rhizoma Rhei liquid 15% activated carbon suspension is prepared), observes incubation period and the fecal grains of arranging melena in 8 hours.Umbilicus subsides group compares with CHANGYANNING PIAN group and normal saline group, obviously can extend the incubation period of mice row melena, reduce melena quantity, have obvious anti-diarrhea effect.The results are shown in Table 1.

Table 1 is on the impact of mice defecation

2, on the impact that mouse small intestine is wriggled

Mouse model totally 60, male and female half and half, divide equally 4 groups: umbilicus subsides group, CHANGYANNING PIAN group, berberine hydrochloride group, normal saline group at random.Mice administration 6 days, every day 1 time, dosage is the same, fasting 24h, 1h after last medicine after the 5th administration, and each group gavage gives the normal saline (0.3ml/10g) containing 15 % carbonic inks.After administration, 15min takes off neck execution, and open clip upper end, abdominal cavity to pylorus, lower end, to the intestinal tube of ileocecus, is placed on pallet.Gently small intestinal is pulled into straight line, measure Length of intestine.From pylorus to the distance in prepared Chinese ink forward position as prepared Chinese ink at enteral advance distance.Use formulae discovery ink progradation.

Ink progradation (%)=prepared Chinese ink is at enteral advance distance (cm)/total small intestinal length (cm) × 100%

The impact that table 2 is wriggled on mouse small intestine

Result shows that umbilicus of the present invention pastes can effectively reduce small intestinal peristalsis frequency, and effect is better than CHANGYANNING PIAN.

Clinical trial data (one)

1, patient data

With reference to the diagnosis basis in " Chinese medical disease Standardization of diagnosis and curative effect ", random collecting is gone to a doctor in acute enteritis patient 50 example of Shandong Prov. Hospital Digestive System Department outpatient service, wherein male 22 example, women 28 example, and patient age is 16 ~ 59 years old, and the course of disease is 1 ~ 5 day; Before medication, 50 routine patients symptomatic are embodied in abdominal distention, stomachache, diarrhoea, Nausea and vomiting.

2, Therapeutic Method and therapeutic evaluation

Cleaned by umbilicus area skin, note applies patch of the present invention, changes 1 every day.

Carry out therapeutic evaluation with reference to " new Chinese medicine guideline of clinical investigations ": 1. fully recover: transference cure or substantially disappear, and therapeutic index >=90%; 2. effective: symptom obviously alleviates, most of sign disappears, therapeutic index >=70%; 3. effective: symptom alleviates, part sign disappears, therapeutic index >=35%; 4. invalid: symptom and sign without alleviating or adding severe one, therapeutic index ﹤ 35%.

Therapeutic index (nimodipine method)=[before (before treatment, integration ﹣ treats rear integration)/treatment integration] × 100%

3, therapeutic outcome

After treatment, 34 examples are cured, and cure rate is 68%; 13 examples are effective, and obvious effective rate is 26%; Effectively, effective percentage is 6% to 3 examples; Total effective rate is 100%; Without irritated and untoward reaction.

In addition, all patients stimulate over the course for the treatment of, irritated and other any untoward reaction.

4, model case

Case one: Liu, man, 19 years old.Stomachache, diarrhoea before medication; Use the embodiment of the present invention 1 umbilicus to paste, medication is after 1 day, and symptom alleviates, and continuous use is after 2 days, transference cure.

Case two: Wang, female, 41 years old.Abdominal distention, stomachache, Nausea and vomiting before medication; Use the embodiment of the present invention 1 umbilicus to paste, medication is after 1 day, and symptom alleviates, and continuous use is after 3 days, transference cure.

Case three: week certain, female, 52 years old.Stomachache before medication, Nausea and vomiting sour, diarrhoea; Use the embodiment of the present invention 2 umbilicus to paste, medication, after 1 day, is suffered from diarrhoea, stomachache, and nausea alleviates; Continuous use is after 2 days, stomachache, and feel sick, symptom of diarrhea disappears, symptoms of emesis alleviates, and continuous use is after 3 days, transference cure, then continues medication 2 days consolidate curative effect.

Clinical trial data (two)

1, patient data

With reference to the diagnosis basis in " Chinese medical disease Standardization of diagnosis and curative effect ", random collecting in May, 2012 ~ in January, 2014, go to a doctor in acute enteritis patient 60 example of Shandong Prov. Hospital Digestive System Department outpatient service, be divided into 4 groups at random, often organize 15 examples.Treatment group 1 and 2 is for using medicine group of the present invention totally 30 examples, and wherein man 11 is routine, female 19 example, 42 years old mean age; Matched group 1 is that CHANGYANNING PIAN (Kang Enbei) organizes 15 examples, wherein man 8 example, female 7 example, 42 years old mean age; Matched group 2 is norfloxacin group 15 example, wherein man 9 example, female 6 example, 43 years old mean age.

2, Therapeutic Method and therapeutic evaluation

Treatment group 1: the embodiment of the present invention 1 medicine, cleaned by umbilicus area skin, note applies patch of the present invention, changes 1 every day.

Treatment group 2: the embodiment of the present invention: 2 medicines, cleans umbilicus area skin, and note applies patch of the present invention, changes 1 every day.

Matched group 1: CHANGYANNING PIAN (Kang Enbei) group, 3 times on the one, ante cibum, 30min took.

Matched group 2: oral norfloxacin, each 10mg, every day 3 times, ante cibum, 30min took.

Therapeutic evaluation: recovery from illness, remarkable, effective, invalid.

3, therapeutic outcome (see table 3)

Table 3 treatment group and matched group patient outcomes

Therapeutic outcome is analyzed: shown by clinical patients statistical data, medicine of the present invention has the digestant effect of function of gallbladder promoting, drug safety, easy to use, instant effect.Solve because oral drug preparation produces pessimal stimulation to gastrointestinal tract simultaneously and increase the weight of the drawback of Liver and kidney burden, some untoward reaction that the toxic component avoided because existing in raw material of Chinese medicine medicine causes after taking.

Claims (3)

1. a umbilicus for the treatment of acute enteritis pastes, it is characterized in that, be made up of the crude drug of following weight parts: Herba Artemisiae Anomalae 20 ~ 25, Herba Dichodrae 16 ~ 20, Flos Chrysanthemi 20 ~ 30, Herba Solani Lyrati 16 ~ 25, Radix et Caulis Opuntiae Dillenii 18 ~ 26, Fructus Mume 12 ~ 16, the Radix Aucklandiae 6 ~ 8, the Radix Linderae 5 ~ 8, Rhizoma Atractylodis 12 ~ 16, Exocarpium Benincasae 12 ~ 16, Halloysitum Rubrum 16 ~ 25, Flos Caryophylli 12 ~ 16 and Radix Glycyrrhizae 8 ~ 10.

2. the preparation method that the umbilicus for the treatment of acute enteritis described in claim 1 pastes, it is characterized in that, step comprises:

1) Herba Artemisiae Anomalae of ormal weight is taken, Herba Dichodrae, Flos Chrysanthemi, Herba Solani Lyrati, Radix et Caulis Opuntiae Dillenii, Fructus Mume, the Radix Aucklandiae, the Radix Linderae, Rhizoma Atractylodis, Exocarpium Benincasae, Flos Caryophylli and Radix Glycyrrhizae, cleaning is dried, pulverizing to 80 ~ 90 order, mix homogeneously, the concentration adding medical material gross weight 3 ~ 5 times is the ethanol water sealing immersion 10 ~ 15 days of 80% ~ 90%, period stirs twice, filter, filtering residue adds 95% soak with ethanol 3 ~ 5 h of 2 ~ 3 times, reflux, extract, 1 ~ 2h, cooling is filtered, merging filtrate, evaporate to dryness, add the Halloysitum Rubrum of ormal weight, mixing pulverizing to 30 ~ 40 order, obtain Chinese medicine extract, for subsequent use,

2) the medical dimethyl sulfoxide of 0.5 ~ 0.8 part is taken, the laurocapram of 0.3 ~ 0.6 part, the Borneolum Syntheticum of the menthol of 1 ~ 3 part and 1 ~ 3 part, mix homogeneously, joins in the purified water of 15 ~ 20 parts, is slowly stirred to and is sufficiently uniformly dissolved, obtain penetration enhancer mixed liquor, for subsequent use;

3) Chinese medicine extract 40 ~ 50 parts of step 1) obtained and step 2) the penetration enhancer mixed liquor that obtains, join in the glycerol of 40 ~ 60 parts, stir 20 ~ 30min, ultrasonic 10min, for subsequent use;

4) take the Cera Flava of 30 ~ 50 parts, after dissolving, add in the glycerol of step 3), stir 8 ~ 17min, ultrasonic to mix homogeneously, obtain ointment, for subsequent use;

5) step 4) gained ointment is heated, uniform application on cotton, in 25 ~ 30 DEG C, under humidity 55 ~ 60% condition, leave standstill 2 ~ 3 days, obtain the umbilicus that the present invention treats acute enteritis and paste.

3. umbilicus according to claim 1 pastes, and it is characterized in that: external, uses warm water cleaning, dry around umbilical part, tablet is aimed at umbilical part, firm pasting.