CN104547132A - Solid preparation for preventing and treating myocardial cell injury caused by chemotherapeutic drugs and preparation method of solid preparation - Google Patents
Solid preparation for preventing and treating myocardial cell injury caused by chemotherapeutic drugs and preparation method of solid preparation Download PDFInfo
- Publication number
- CN104547132A CN104547132A CN201510049201.5A CN201510049201A CN104547132A CN 104547132 A CN104547132 A CN 104547132A CN 201510049201 A CN201510049201 A CN 201510049201A CN 104547132 A CN104547132 A CN 104547132A
- Authority
- CN
- China
- Prior art keywords
- extract
- solid preparation
- preparation
- chemotherapeutic
- preventing
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/73—Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/25—Araliaceae (Ginseng family), e.g. ivy, aralia, schefflera or tetrapanax
- A61K36/254—Acanthopanax or Eleutherococcus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/73—Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
- A61K36/738—Rosa (rose)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/53—Liquid-solid separation, e.g. centrifugation, sedimentation or crystallization
Abstract
The invention discloses a solid preparation for preventing and treating myocardial cell injury caused by chemotherapeutic drugs and a preparation method of the solid preparation. According to percentage by mass, the solid preparation is prepared by mixing 35-40% of a sorbus pohuashanensis extract, 35-40% of an acanthopanax sessiliflorus extract, 10-15% of an extract of large-fruited Chinese hawthorn and 10-15% of an extract of dahurian rose fruit. The solid preparation disclosed by the invention has the characteristics that by adopting sorbus pohuashanensis which comes from the Northeast and contains a great amount of flavonoids compounds, the solid preparation can effectively inhibit the generation of a free radical, improve myocardial energy and protect myocardial cells; and the solid preparation also has prevention and healthcare effects on myocardial cell injury caused by chemotherapeutic drugs and is suitable for various health care people; and moreover, the solid preparation is relatively good in antioxidant effect and can be used for relieving the toxic and side effects of patients of cancers in chemotherapy.
Description
Technical field
The present invention relates to a kind of chemotherapeutics of can preventing and treating and produce solid preparation of myocardial damage and preparation method thereof.
Background technology
The treatment of cancer has been the content that medical worker pays close attention to.Chemotherapy, operative treatment, actinotherapy are the carriages drawn by a team of three horses of Therapeutic cancer.Wherein chemotherapy uses the medicines such as chemicals, Chinese medicine, biological gene product all to serve good effect for the treatment of cancer.
Cancer patient dies from cancer itself, but dies from the other diseases that chemotherapy causes.Present great many of experiments shows, the damage of myocardial cell be receive various peroxide erosion and produce.So reduce the most important thing that the material such as oxygen-derived free radicals, hydrogen peroxide also becomes protecting myocardial cell.So application antioxidant resist produce myocardial damage oxidative stress path and apoptosis path is an effective action pathway.
Show according to the study, antioxidant produces as injection Vitamin B_6 can reduce over lipid oxide, and reduce the blood vessel endothelial factor damage of hydrogen peroxide-induced, prevention and cure of cardiovascular disease all has good curative effect.In natural plant, a large amount of polyphenol, flavone compound are also found to have good antioxidation.
Summary of the invention
The object of this invention is to provide a kind of effectively can prevent and treat chemotherapeutics prevent and treat solid preparation of chemotherapeutic damaged cardiomyocytes and preparation method thereof.
The object of the invention is to be achieved through the following technical solutions:
Prevent and treat a solid preparation for chemotherapeutic damaged cardiomyocytes, mass percent is mixed by 35-40% Mt. baihuashan mountainash extract, 35-40% Cortex Acanthopancis extract, 10-15% Fructus Pyri Pashiae extract, 10-15% rose hip extract.
The above-mentioned solid preparation preventing and treating chemotherapeutic damaged cardiomyocytes is prepared according to the following steps:
1) hundred China's flowers, Cortex Acanthopancis, Fructus Pyri Pashiae, rose hip are proceeded as follows respectively: get raw material drying, be broken into bulky grain, put in extraction element, add the alcoholic solution that volumetric concentration is 50 ~ 70%, be that 50 ~ 100:10 measures submergence medical material by ethanol and volume of material ratio, ultrasonic 10 ~ 20 minutes, temperature was 50 ~ 60 DEG C, and after extraction, sucking filtration obtains settled solution, filtrate is placed in Rotary Evaporators, reclaim reagent, then by surplus solution evaporate to dryness, gained solid is put into pulverizer and pulverizes.
2) Mt. baihuashan mountainash extract step 1) obtained, Cortex Acanthopancis extract, Fructus Pyri Pashiae extract, rose hip extract mix, and must prevent and treat the solid preparation of chemotherapeutic damaged cardiomyocytes.
Tool of the present invention has the following advantages:
1, the solid preparation primary raw material preventing and treating chemotherapeutic damaged cardiomyocytes of the present invention is all pure natural plant ingredients, to human non-toxic's side effect, due to containing a large amount of flavones ingredient, has good effect to suppression free radical raising cardiac energy.
2, distinctive feature of the present invention is the Mt. baihuashan mountainash adopting northeast, and containing a large amount of flavone compounds in Mt. baihuashan mountainash fruit, the effective generation suppressing free radical, improves the energy of cardiac muscle, protecting myocardial cell.And the myocardial damage that chemotherapeutics produces also is had to the effect of prevention and health care, be applicable to all kinds of health care crowd, and have good antioxidant effect, the toxic and side effects of cancer patient in chemotherapy can also be reduced.
3, the plant component that this product contains is harmful to human health, and is applicable to all kinds of crowd's long-term drink, comprises child.
Accompanying drawing explanation
Fig. 1 for Mt. baihuashan mountainash total flavones on arsenic trioxide cause the impact of the cells survival rate of myocardial cell injury.
Detailed description of the invention
Below in conjunction with accompanying drawing, technical scheme of the present invention is further described; but be not limited thereto; everyly technical solution of the present invention modified or equivalent to replace, and not departing from the spirit and scope of technical solution of the present invention, all should be encompassed in protection scope of the present invention.
Detailed description of the invention one: the solid preparation preventing and treating chemotherapeutic damaged cardiomyocytes of present embodiment is mixed by 38% Mt. baihuashan mountainash extract, 38% Cortex Acanthopancis extract, 12% Fructus Pyri Pashiae extract, 12% rose hip extract by mass percentage, and concrete preparation process is as follows:
1) powder method is prepared: hundred China's flowers, Cortex Acanthopancis, Fructus Pyri Pashiae, rose hip are proceeded as follows respectively: get raw material drying, be broken into bulky grain, put in extraction element, add 50vol.% alcoholic solution, be 50:10(v/v by ethanol and material ratio) measure submergence medical material, ultrasonic 10 minutes, temperature was 50 DEG C.After extraction, sucking filtration obtains settled solution.Filtrate is placed in Rotary Evaporators, reclaims reagent.Again by surplus solution evaporate to dryness.Gained solid is put into pulverizer and pulverizes to obtain pressed powder.
2) Mt. baihuashan mountainash extract, Cortex Acanthopancis extract, Fructus Pyri Pashiae extract, rose hip extract are mixed in proportion, the solid preparation of chemotherapeutic damaged cardiomyocytes must be prevented and treated.
Detailed description of the invention two: present embodiment and detailed description of the invention one unlike, described solid preparation is mixed by 40% Mt. baihuashan mountainash extract, 40% Cortex Acanthopancis extract, 10% Fructus Pyri Pashiae extract, 10% rose hip extract by mass percentage.
Detailed description of the invention three: present embodiment and detailed description of the invention one unlike, described solid preparation is mixed by 35% Mt. baihuashan mountainash extract, 35% Cortex Acanthopancis extract, 15% Fructus Pyri Pashiae extract, 15% rose hip extract by mass percentage.
Fig. 1 for Mt. baihuashan mountainash total flavones on arsenic trioxide cause the impact of the cells survival rate of myocardial cell injury, wherein: abscissa is the impact on cells survival rate in experiment, vertical coordinate be each administration group compared with blank group, the existence percentage rate of myocardial cell.As shown in Figure 1, blank group is normal myocardial cells survival rate, is set as 100%; Mt. baihuashan mountainash total flavones administration group is 100.28% with blank group ratio; Arsenic trioxide group is 72.59% with blank group ratio; Administering drug combinations group is 86.99% with blank group ratio.In arsenic trioxide group and the blank T organized are checked and compared, there is significant difference (P<0.001); In the T of administering drug combinations group and arsenic trioxide group checks, there is significant difference (P<0.001).
Result shows, Mt. baihuashan mountainash total flavones is on normal myocardial cells without too large impact, and arsenic trioxide has obvious damaging action to myocardial cell, and for both drug combination groups, myocardial cell is obviously protected.
Claims (7)
1. prevent and treat a solid preparation for chemotherapeutic damaged cardiomyocytes, it is characterized in that described solid preparation is mixed by 35-40% Mt. baihuashan mountainash extract, 35-40% Cortex Acanthopancis extract, 10-15% Fructus Pyri Pashiae extract, 10-15% rose hip extract by mass percentage.
2. the solid preparation preventing and treating chemotherapeutic damaged cardiomyocytes according to claim 1, is characterized in that described solid preparation is mixed by 38% Mt. baihuashan mountainash extract, 38% Cortex Acanthopancis extract, 12% Fructus Pyri Pashiae extract, 12% rose hip extract in mass ratio.
3. the solid preparation preventing and treating chemotherapeutic damaged cardiomyocytes according to claim 1, is characterized in that described solid preparation is mixed by 40% Mt. baihuashan mountainash extract, 40% Cortex Acanthopancis extract, 10% Fructus Pyri Pashiae extract, 10% rose hip extract by mass percentage.
4. the solid preparation preventing and treating chemotherapeutic damaged cardiomyocytes according to claim 1, is characterized in that described solid preparation is mixed by 35% Mt. baihuashan mountainash extract, 35% Cortex Acanthopancis extract, 15% Fructus Pyri Pashiae extract, 15% rose hip extract by mass percentage.
5. the preparation method of preventing and treating the solid preparation of chemotherapeutic damaged cardiomyocytes described in the arbitrary claim of claim 1-4, is characterized in that described method step is as follows:
1) hundred China's flowers, Cortex Acanthopancis, Fructus Pyri Pashiae, rose hip are proceeded as follows respectively: get raw material drying, be broken into bulky grain, put in extraction element, add alcoholic solution submergence medical material, ultrasonic 10 ~ 20 minutes, temperature is 50 ~ 60 DEG C, after extraction, sucking filtration obtains settled solution, and filtrate is placed in Rotary Evaporators, reclaims reagent, again by surplus solution evaporate to dryness, gained solid is put into pulverizer and pulverizes;
2) Mt. baihuashan mountainash extract step 1) obtained, Cortex Acanthopancis extract, Fructus Pyri Pashiae extract, rose hip extract mix, and must prevent and treat the solid preparation of chemotherapeutic damaged cardiomyocytes.
6. preparation method of preventing and treating the solid preparation of chemotherapeutic damaged cardiomyocytes according to claim 5, is characterized in that the volumetric concentration of described alcoholic solution is 50 ~ 70%.
7. the preparation method of preventing and treating the solid preparation of chemotherapeutic damaged cardiomyocytes according to claim 5 or 6, is characterized in that the volume ratio of described ethanol and material is 50 ~ 100:10.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510049201.5A CN104547132A (en) | 2015-01-31 | 2015-01-31 | Solid preparation for preventing and treating myocardial cell injury caused by chemotherapeutic drugs and preparation method of solid preparation |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510049201.5A CN104547132A (en) | 2015-01-31 | 2015-01-31 | Solid preparation for preventing and treating myocardial cell injury caused by chemotherapeutic drugs and preparation method of solid preparation |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN104547132A true CN104547132A (en) | 2015-04-29 |
Family
ID=53064903
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201510049201.5A Pending CN104547132A (en) | 2015-01-31 | 2015-01-31 | Solid preparation for preventing and treating myocardial cell injury caused by chemotherapeutic drugs and preparation method of solid preparation |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN104547132A (en) |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1729859A (en) * | 2005-08-11 | 2006-02-08 | 沈阳市华星药物研究所 | Anti-fatigue health-caring food |
| CN103385501A (en) * | 2012-05-07 | 2013-11-13 | 纪玉杰 | Large-fruited Chinese hawthorn juice |
-
2015
- 2015-01-31 CN CN201510049201.5A patent/CN104547132A/en active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1729859A (en) * | 2005-08-11 | 2006-02-08 | 沈阳市华星药物研究所 | Anti-fatigue health-caring food |
| CN103385501A (en) * | 2012-05-07 | 2013-11-13 | 纪玉杰 | Large-fruited Chinese hawthorn juice |
Non-Patent Citations (1)
| Title |
|---|
| 樊梓鸾等: "5种野生浆果的抗氧化和抗细胞增殖活性", 《食品科学》 * |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| Kuntić et al. | Radioprotectors–the evergreen topic | |
| Haniadka et al. | Medicinal plants as antiemetics in the treatment of cancer: a review | |
| KR20130117660A (en) | Tocotrienol compositions | |
| Chivte et al. | A review on therapeutic applications of phytosomes | |
| EP3643295A1 (en) | Composition containing cirsium japonicum extract as active ingredient for stimulating melanogenesis | |
| Suziana Zaila et al. | Antiproliferative effect of Lignosus rhinocerotis, the Tiger Milk Mushroom on HCT 116 human colorectal cancer cells | |
| CN104523472B (en) | A kind of bamboo-leaves flavones complex liposome, preparation method and applications | |
| CN102961282A (en) | Composition with penetration enhancing effect as well as preparation method and application thereof | |
| Jit et al. | Phytochemicals: A potential next generation agent for radioprotection | |
| Ramedani et al. | Processing of liposome-encapsulated natural herbs derived from Silybum marianum plants for the treatment of breast cancer cells | |
| Sidhu et al. | Silybum marianum: a plant of high medicinal importance—a review | |
| CN104491339A (en) | Seabuckthorn leaf composition for preventing and treating hyperlipidaemia and resisting thrombus and preparation method thereof | |
| CN104547132A (en) | Solid preparation for preventing and treating myocardial cell injury caused by chemotherapeutic drugs and preparation method of solid preparation | |
| CN104436116B (en) | A kind of rosemary lavipeditum powder and preparation method thereof | |
| Yoseph et al. | The Importance of Fermented Active for Anti Aging incosmetics Product | |
| CN103520279B (en) | The application of cinnamon extract in the medicine preparing treatment or prophylaxis of tumours or health product | |
| CN105287335A (en) | Fresh rose flower cell sap skin rejuvenation solution and preparation method thereof | |
| CN101032336B (en) | Pearl flavone nutrient health care food and preparation process thereof | |
| Onuah et al. | Ethanol extract of acalypha wilkesiana muel arg leaves ameliorates paracetamol-induced hepatotoxicity in rats | |
| CN103585330B (en) | A kind of Chinese medicine composition for cutaneous fungal infection and preparation method thereof | |
| CN103893553B (en) | A kind of surface of a wound Chinese medicine compound prescription film and preparation method thereof | |
| KR101611966B1 (en) | Production of antlers and medicinal herbs extract for arthritis care medicine | |
| CN116270873B (en) | Traditional Chinese medicine composition for treating dermatophyte infection | |
| CN101401877A (en) | Composition capable of restraining and removing free radical | |
| CN101732637A (en) | Chinese medicament for treating cardiovascular and cerebrovascular diseases |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| RJ01 | Rejection of invention patent application after publication | ||
| RJ01 | Rejection of invention patent application after publication |
Application publication date: 20150429 |