CN104547064A - Pharmaceutical composition for treating facial telangiectasis and preparation method and use thereof - Google Patents
Pharmaceutical composition for treating facial telangiectasis and preparation method and use thereof Download PDFInfo
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Abstract
The invention discloses a pharmaceutical composition for treating facial telangiectasis and a preparation method and use thereof. Raw materials of the pharmaceutical composition are all natural soothing ingredients and are nonirritant to skin. The pharmaceutical composition with a facial telangiectasis treating effect is prepared from phyllanthus urinaria, polygala fallax hemsl, hypericum japonicum, gynostemma pentaphyllum, centella asiatica, kalimeris indica, mulberry leaves and euphorbia royleana, wherein the weight percent of any ingredient is not higher than 30% the overall weight. The raw materials of the pharmaceutical composition disclosed by the invention are simply obtained, and the preparation method is convenient. Proved by clinical trial results, the pharmaceutical composition disclosed by the invention has a good effect on the treatment of the facial telangiectasis, is nonirritant and non-allergic to the skin, is easily accepted by mass consumers, and has good application prospect and market prospect.
Description
Technical field
The present invention relates to a kind of pharmaceutical composition and preparation method thereof and purposes, particularly there is pharmaceutical composition used for cosmetic for the treatment of red blood trace on face effect and preparation method thereof and a purposes, be suitable for the face cosmetic making an addition to cream class, white class, newborn class, liquid class (except perfume).
Background technology
Red blood trace on face, medically be also called facial telangiectasias, namely the elasticity of capillary wall reduces, fragility strengthens, the uneven expansion of continuous vessel is even broken, and causes skin of face general red, the blood capillary that naked eyes are expanded as seen, often with red or aubergine plaque-like, point-like, wire or starlike etc. phenomenon, be called telangiectasia.(Domingo DS, Camouse MM, Hsia AH, Matsui M, Maes D, Ward NL, Cooper KD, Baron ED.Anti-angiogenic effects of epigallocatechin-3-gallate in human skin.Int J Clin Exp Pathol, 2010,3 (7): 705-709) means of curing red blood streak at present are both at home and abroad main mainly with laser therapy physical method, namely by selective light pyrolysis principle, act on the hemoglobin in lesion vessels, make lesion vessels pyrolysis, absorption, disappearance.But laser therapy has pain, operation consent will use antalgica, tranquillizer or anesthetis in advance.If nurse after treatment and improperly very easily cause the side effect such as pigmentation and inflammatory reaction, and price comparison is expensive, many patients cannot accept.(Desiate A, Cantore S, Tullo D, Profeta G, Grassi FR, Ballini is diode lasers in oral and facial practice:current state of the science and art.Int J Med Sci A.980nm, and 2009,6 (6): 358-64; Wang Juan. the clinical efficacy of intense pulsed light 540nm union and recombination human/bovine basic fibroblast growth factor treatment Treatment of telangiectasia. Chinese medical aesthetics beauty treatment magazine, 2010,16 (4): 220-223) red blood trace on face can be treated by external use skin care in fact, only has French Ji Jia cosmeceutical company (Avene at present, reason skin spring, L'Oreal) release specially for the cosmetics of red blood streak, its functional raw material is to repair blood capillary, and curative effect is not good enough.Scientist is through studying discovery for a long period of time, and many natural plants by the mechanism control red blood trace on face of three aspects, specifically can comprise: the barrier function 1, increasing skin, this kind of plant has Flos Matricariae chamomillae, Arnica montana, Caulis Hederae Sinensis, Radix et Caulis Opuntiae Dillenii etc.2, repair blood capillary, repairing blood capillary is the committed step removing red blood streak, and this kind of plant mainly contains Radix Hamamelidis Mollis, Aesculus chinensis Bunge, butchers broom, Flos Matricariae chamomillae etc.3, the vigor of collagen protein and elastin laminin is strengthened, Folium Mori are outstanding representatives, mulberry leaf polyphenol (flavone, tannin, catechin, front anthocyanidin) except strengthening the elasticity of blood vessel, outside blood circulation promoting, strengthen skin collagen in addition, the vigor of elastin laminin simultaneously.(Liu Wenting, Wang Haitao, Dong Yinmao. red blood trace on face formation mechenism and study on prevention progress. Chinese aesthetic medicine, 2009,18 (3): 401404; Liu Wenting, He Congfen, Dong Yinmao. suppress the Biological Mechanism of facial telangiectasias and relevant Chinese herbal medicine. northern gardening, 2011,22 (1): 196-199) natural drug of exploitation treatment red blood trace on face better effects if has become the problem in science of medicine scholar and dermatologist general concern.As number of patent application 201210501919.X, disclose in this application and a kind ofly have the external medicine composition of dispelling red blood trace on face effect, described compositions is made up of the crude drug of following weight parts proportioning: Semen Phaseoli 20-50, Fructus Mume 20-40, Radix Hamamelidis Mollis 2040, Radix Salviae Miltiorrhizae 10-30, Herba Hyperici perforati 10-30.For another example number of patent application 201210209478.6, which disclose a kind of method for the treatment of red blood trace on face, described method the egg yolk boiled is put into frying pan to fry to fuel-displaced, 10-15 minute is fried in fuel-displaced rear continuation, egg yolk is taken out edible, in addition the oil fried out is poured out, after cooling, be applied in red blood streak place partner treatment.For another example number of patent application 201010572396.9, which disclose and a kind ofly have the pharmaceutical composition of dispelling red blood trace on face effect, described compositions comprises A phase and B phase, and described A phase comprises water solublity ceramide, VA cetylate and cholesteryl stearate; Described B phase comprises Chinese medicine extract.For another example number of patent application 201010280995.3, which discloses and a kind ofly has Chinese medicine extract of dispelling red blood trace on face effect and preparation method thereof and application.This Chinese medicine extract is made up of Radix Et Rhizoma Rhei, the Flos Sophorae Immaturus, the Radix Astragali and the Flos Matricariae chamomillae ratio according to ratio of quality and the number of copies 30-50:15-25:15-25:5-15.
In sum, along with growth in the living standard, the serious hope of people to " body and the spirit is all beautiful " is further strong, and particularly in the today being turned to biology-psychology-social medicine pattern by biomedical model, beautiful appearance becomes the target that people pursue.Facial telangiectasias is one of principal element of impact beauty treatment, not only affect the appearance of people, and have a strong impact on skin and draw nourishment from, in the course of time skin is caused to be supported not enough, cause coarse, the dry symptom with crossing presenility, development of new external is safely and effectively dispelled red blood streak product and is had good Social and economic benef@.
Summary of the invention
The object of the invention is to overcome weak point of the prior art, a kind of pharmaceutical composition and the preparation technology thereof with the effect for the treatment of red blood trace on face are provided.
The pharmaceutical composition with the effect for the treatment of red blood trace on face of the present invention, with Herba Phyllanthi Urinariae, Radix Polygalae fallacis, Herba Hyperici Japonici, Herb Gynostemmae Pentaphylli, Herba Centellae, Herba Kalimeridis, Folium Mori and Euphorbia royleana Boiss. for prepared by raw material, and the weight percentage of any component is all no more than 30% of total amount;
The pharmaceutical composition for the treatment of red blood trace on face, it is characterized in that, it is prepare with the raw material of following mass fraction: Herba Phyllanthi Urinariae 1 ~ 60 part, Radix Polygalae fallacis 1 ~ 60 part, Herba Hyperici Japonici 1 ~ 60 part, Herb Gynostemmae Pentaphylli 1 ~ 60 part, Herba Centellae 1 ~ 60 part, Herba Kalimeridis 1 ~ 60 part, 1 ~ 60 part, Folium Mori, Euphorbia royleana Boiss. 1 ~ 60 part.
The pharmaceutical composition for the treatment of red blood trace on face, it is characterized in that, it is prepare with the raw material of following mass fraction: Herba Phyllanthi Urinariae 1 ~ 50 part, Radix Polygalae fallacis 1 ~ 50 part, Herba Hyperici Japonici 1 ~ 50 part, Herb Gynostemmae Pentaphylli 1 ~ 50 part, Herba Centellae 1 ~ 50 part, Herba Kalimeridis 1 ~ 50 part, 1 ~ 50 part, Folium Mori, Euphorbia royleana Boiss. 1 ~ 50 part.
Preferably, described in there is the pharmaceutical composition for the treatment of red blood trace on face effect, be prepare with the raw material of following parts by weight:
Herba Phyllanthi Urinariae 1 ~ 40 part
Radix Polygalae fallacis 1 ~ 40 part
Herba Hyperici Japonici 1 ~ 40 part
Herb Gynostemmae Pentaphylli 1 ~ 40 part
Herba Centellae 1 ~ 40 part
Herba Kalimeridis 1 ~ 40 part
1 ~ 40 part, Folium Mori
Euphorbia royleana Boiss. 1 ~ 40 part
Preferably, described in there is the pharmaceutical composition for the treatment of red blood trace on face effect, be prepare with the raw material of following parts by weight:
Herba Phyllanthi Urinariae 2 ~ 35 parts
Radix Polygalae fallacis 2 ~ 35 parts
Herba Hyperici Japonici 2 ~ 35 parts
Herb Gynostemmae Pentaphylli 2 ~ 35 parts
Herba Centellae 2 ~ 35 parts
Herba Kalimeridis 2 ~ 35 parts
2 ~ 35 parts, Folium Mori
Euphorbia royleana Boiss. 2 ~ 35 parts
Preferably, described in there is the pharmaceutical composition for the treatment of red blood trace on face effect, be prepare with the raw material of following parts by weight:
Herba Phyllanthi Urinariae 8 ~ 30 parts
Radix Polygalae fallacis 8 ~ 30 parts
Herba Hyperici Japonici 8 ~ 30 parts
Herb Gynostemmae Pentaphylli 8 ~ 30 parts
Herba Centellae 10 ~ 30 parts
Herba Kalimeridis 10 ~ 30 parts
10 ~ 30 parts, Folium Mori
Euphorbia royleana Boiss. 10 ~ 30 parts
Most preferred, be prepare with the raw material of following parts by weight:
Herba Phyllanthi Urinariae 10 parts
Radix Polygalae fallacis 10 parts,
Herba Hyperici Japonici 10 parts
Herb Gynostemmae Pentaphylli 10 parts
Herba Centellae 10 parts
Herba Kalimeridis 10 parts
10 parts, Folium Mori
Euphorbia royleana Boiss. 10 parts
Most preferred, be prepare with the raw material of following parts by weight:
Herba Phyllanthi Urinariae 8 parts
Radix Polygalae fallacis 8 parts
Herba Hyperici Japonici 8 parts
Herb Gynostemmae Pentaphylli 12 parts
Herba Centellae 12 parts
Herba Kalimeridis 12 parts
12 parts, Folium Mori
Euphorbia royleana Boiss. 8 parts
Most preferred, be prepare with the raw material of following parts by weight:
Herba Phyllanthi Urinariae 8 parts
Radix Polygalae fallacis 8 parts
Herba Hyperici Japonici 15 parts
Herb Gynostemmae Pentaphylli 15 parts
Herba Centellae 15 parts
Herba Kalimeridis 15 parts
15 parts, Folium Mori
Euphorbia royleana Boiss. 8 parts
Most preferred, be prepare with the raw material of following parts by weight:
Herba Phyllanthi Urinariae 10 parts
Radix Polygalae fallacis 10 parts
Herba Hyperici Japonici 10 parts
Herb Gynostemmae Pentaphylli 12 parts
Herba Centellae 12 parts
Herba Kalimeridis 12 parts
12 parts, Folium Mori
Euphorbia royleana Boiss. 10 parts
Most preferred, be prepare with the raw material of following parts by weight:
Herba Phyllanthi Urinariae 8 parts
Radix Polygalae fallacis 8 parts
Herba Hyperici Japonici 8 parts
Herb Gynostemmae Pentaphylli 10 parts
Herba Centellae 10 parts
Herba Kalimeridis 10 parts
15 parts, Folium Mori
Euphorbia royleana Boiss. 8 parts
The preparation method with the pharmaceutical composition for the treatment of red blood trace on face effect of the present invention, comprises the following steps:
(1) each above-mentioned raw material is placed in volumetric concentration be 20% ~ 80% ethanol soak 2 ~ 48 hours, the ethanol consumption soaked is 10 ~ 200 times of each raw material gross weight, filters, obtains soak;
Preferably, filtration residue is the soak with ethanol 2 ~ 48 hours of 20% ~ 80% again by volumetric concentration, merges the solution after soaking, obtains soak.
(2) soak is concentrated into 2 ~ 5% of original weight amount, concentrated solution macroporous resin adsorption, then uses the ethanol repeatedly eluting of volumetric concentration 5 ~ 95%, collects eluent, is the described pharmaceutical composition with the effect for the treatment of red blood trace on face;
Preferably, the volumetric concentration of ethanol is 40% ~ 95%;
Described macroporous resin employing Mitsubishi chemical company take polymethacrylates as the HP2MGL type macroporous resin of matrix; The method that soak concentrates is conventional concentrating under reduced pressure.
Test proves, the pharmaceutical composition with treatment red blood trace on face effect of the present invention, has and waits multiple action, can be used in preparation and treats the cosmetics of red blood trace on face and the curative drug of skin;
The invention still further relates to a kind of skin care cosmetics, there is described in comprising the pharmaceutical composition for the treatment of red blood trace on face effect and the adjuvant of cosmetic field use;
The invention still further relates to a kind of curative drug of skin, comprise the pharmaceutical composition with the effect for the treatment of red blood trace on face described in claim and medically acceptable carrier.
Especially may be used for preparing face skin nursing cosmetics, comprise cream, emulsion, astringent, gel, facial film, liniment or lotion;
During preparation skin care cosmetics, can by obtained extracting solution compositions, through being evaporated to 10% ~ 50% of original weight amount, obtain composition concentrated solution, mix mutually with the substrate of known cosmetics and medicine or adjuvant, carrier, additive, conventionally be prepared, wherein, described composition concentrated solution accounts for 5% ~ 10% of cosmetics gross weight.
Motherland's medical science is thought, the appearance of Treatment of telangiectasia is due to ferritic YinXuXueRe, Tianjin insufficiency of blood, the stagnant caused failure of skin and muscle to be nourished of the venation stasis of blood, xerosis cutis, thus keratinization is accelerated, thinning of skin, and " blushing " occurs.We think that telangiectasis main reason is deficiency of YIN-blood in body, blood deficiency heat-dissipating; Various factors causes skin injury outside, blood network stasis blocking.Root of the present invention it is documented and great many of experiments screening, from a large amount of natural plants, Herba Phyllanthi Urinariae, Radix Polygalae fallacis, Herba Hyperici Japonici, Herb Gynostemmae Pentaphylli, Herba Centellae, Herba Kalimeridis, Folium Mori and Euphorbia royleana Boiss. has been selected to be raw material, prepare the described pharmaceutical composition with the effect for the treatment of red blood trace on face, wherein, described Herba Phyllanthi Urinariae selects halberd section Herba Phyllanthi Urinariae to belong to the dry herb of Phylanthus urinaria L.; Radix Polygalae fallacis selects the root of milk wort Polygala fallax Hemsl. [P.aureocauda Dumn]; Herba Hyperici Japonici selects the dry herb of Guttiferae hypericum Herba Hyperici Japonici (Hypericumjaponicum Thumb.); Herb Gynostemmae Pentaphylli selects the dry herb of Cucurbitaceae Gynostemma herbaceous species plant Gynostemma pentaphyllum (Thunb.) Makion; Herba Centellae selects the dry herb of Centella samphire Centella asialica (L.); Herba Kalimeridis selects the dry herb of Compositae Herba Kalimeridis platymiscium Herba Kalimeridis Kalimeris indica (L.) Sch.-Bip.; Folium Mori select the dried leaves of Morus moraceae plants (Morus alba L.); The dry aerial parts of euphorbia Euphorbia royleana Boiss. selected by Euphorbia royleana Boiss..
Root it is documented:
Herba Phyllanthi Urinariae (Phylanthus urinaria L.), for Euphorbiaceae Herba Phyllanthi Urinariae belongs to annual herb plant, has another name called Cacumen Securinegae Suffruticosae, and as a kind of traditional Chinese herbal medicine, Herba Phyllanthi Urinariae has effect of calming liver and clearing heat, promoting diuresis to remove toxic substance.Among the people being mainly used in treats the diseases such as jaundice, hepatitis, enteritis, dysentery, oedema due to nephritis.Modern chemistry and pharmaceutical research show, Herba Phyllanthi Urinariae contains lignanoid, terpenoid, flavone, the multiple compounds such as matter and alkaloid of mixing, and have obvious anti-hepatitis B virus, pharmacological action such as protection hepatic injury and analgesia, blood pressure lowering, antitumor, anticoagulation etc.
Radix Polygalae fallacis (Polygala aureocauda Dunn.) is Polygalaceae polygala, has another name called Radix polygalae arillatae, is a kind ofly to use long traditional herbal medicine.The provinces and regions such as main product Fujian, Jiangxi, Hunan, Guangxi and Yunnan, are born in the mountain valley sylvan life of height above sea level 1150 ~ 1650m, the other dark and damp place of water.Radix Polygalae fallacis sweet in the mouth, micro-hardship, property is put down, tepor; The effect such as tool benefiting vital QI and blood, invigorating the spleen to clear away damp pathogen, blood circulation promoting and blood stasis dispelling, regulating menstruation, it is Guangxi ethnic groups common medicine among the people, its root can nourish, strong, wind-damp dispelling, easypro meridians, treats body void, lumbar muscle strain, rheumatic arthritis, traumatic injury, acute, chronic hepatitis, uterine prolapse and menoxenia after being ill.
Herba Hyperici Japonici (Hypericum japonicum Thumb.) has another name called Herba Hyperici Japonici, Stellaria alsine Grim., little Herba Hyperici Sampsonii, seven layers of tower etc., it is the dry herb of Guttiferae hypericum Herba Hyperici Japonici, sweet in the mouth, micro-hardship, cool in nature, there is effect of clearing away heat-damp and promoting diuresis, eliminating stasis to stop pain, reducing swelling and alleviating pain.Former plant main product ground is the ground such as Jiangxi, Fujian, Guangdong, Guangxi, Sichuan, Guizhou.Clinically be used for the treatment of the subcutaneous pyogenic infection such as acute, chronic hepatitis, acute nephritis, typhoid fever and paratyphoid fever, venom, carbuncle furuncle.
Herb Gynostemmae Pentaphylli (Gynostemma pentaphyllum (Thunb.) Makion) is Cucurbitaceae Gynostemma herbaceous species plant, has another name called Herb Gynostemmae Pentaphylli, Herba Gynostemmatis, Pentapanax, gynostemma pentaphyllum makino, Herba Gynostemmatis, Herb Gynostemmae Pentaphylli, Gospel grass, Herb Gynostemmae Pentaphylli etc.As far back as, within 1986, in Spark Program is listed Herb Gynostemmae Pentaphylli as " rare Chinese medicine " by State Scientific and Technological Commission, and calendar year 2001 State Administration of Forestry's protection department is adjusted to National Wild Conservative Plants Herb Gynostemmae Pentaphylli.Because of the Radix Ginseng soap two containing nutritional labeling identical with Radix Ginseng, therefore there is the good reputation of the second Radix Ginseng and southern Radix Ginseng.It is except containing except 65 kinds of saponin constituents, also containing carbohydrate, aminoacid, vitamin B, C, E and abundant trace element, particularly potassium and calcium.There is effect of antioxidation and promotion cell regeneration, the aging of function, degradation phenomena can be delayed.There is effect of relieving cough and resolving phlegm, eliminating inflammation and expelling toxin and enhancing immunity.And glucocorticoid can be prevented and treated cause adrenocortical atrophy.Patient for hypertension, diabetes has splendid improvement, and can promote appetite and recover vision, drinks energy dispersing wind and cold, relieving cough and reducing sputum while hot, treatment tracheitis.Effect of Herb Gynostemmae Pentaphylli enhancing immunity, not only can match in excellence or beauty with Radix Ginseng, and because of the Herb Gynostemmae Pentaphylli soap two containing Radix Ginseng institute nothing, so do not have the side effect of excessive use Radix Ginseng.
Herba Centellae is the dry herb of Centella samphire Centella asialica (L.), has another name called Glechota longituba (Nakai) Kupr, ground wire grass, Gotu Kola etc.Herba Centellae is the perennial herbaceous plant that crawls, and often crispaturas into bulk, and its stem is elongated, and tuberosity is taken root.Originate in India, be now distributed widely in the torrid zone, the world, subtropical zone district, be mainly distributed in each province on the south the Changjiang river in China.Herba Centellae happiness is born in moistening riverbank, marsh, meadow.TAO Hong-Jing day: this grass is gained the name with cold and cool, its property Great Cold, therefore named Herba Centellae.Herba Centellae begins to be loaded in Shennong's Herbal, and this shows that it has had long medicinal history in China." Chinese Pharmacopoeia ", from version in 1977, later each version pharmacopeia is all recorded, and it has effect of heat-clearing and toxic substances removing, detumescence dampness removing.For jaundice due to damp-heat, heatstroke diarrhoea, sand Stranguria stranguria with blood, carbuncle sore tumefacting virus, injury from falling down.Pharmacological research shows: Herba Centellae extract has outstanding healing of wound and cicatrix repair, and its reason is that asiaticoside has and promotes collage synthesis and the important function such as new vascular generation, the growth of stimulation granulation in body, so be conducive to wound healing.As continuous administration, containing the preparation of asiaticoside, can prevent wound infection from suppurating on skin wound, shorten wound healing time, skin hardness can be reduced and improve skin-nourishing, the effect of enhancing metabolism.
Herba Kalimeridis is the dry herb of Compositae Herba Kalimeridis platymiscium Herba Kalimeridis Kalimeris indica (L.) Sch.-Bip., has another name called Flos Chrysanthemi Indici, Misgurni anguillicaudati string, Herba Kalimeridis are first-class.Widely distributed in China, it is cool in nature, bitter in the mouth, pungent, returns lung, liver, stomach warp, has effect of heat-clearing and toxic substances removing, dissipation carbuncle, dispelling wind suppressing the hyperactive liver, records that " Herba Kalimeridis, most relieving heat toxin, specially can enter blood system, hemostasis removing heat from blood, especially speciality in " book on Chinese herbal medicine justice ".All warm heresies, deeply battalion point, and carbuncle and ulcer heat in blood, the cards such as decomposed, permit for special medicine.Orally taken and externally, it is with very wide, also heat-clearing and toxic substances removing want product also.If call its broken stagnated blood and tissue regeneration promoting blood, then put it strong ".Clinically be used for the treatment of the diseases such as cat fever, cough, acute pharyngitis, tonsillitis, mumps, infectious hepatitis, gastric and duodenal ulcers.Its decoction conventional among the people in Sichuan, treatment gastralgia and chronic gastritis, all have good therapeutic effect.
Folium Mori are dried leaves of Morus moraceae plants (Morus alba L.), " Bencao Jingshu ": Folium Mori nature and flavor are sweet, cold, sweet so beneficial blood, cold so removing heat from blood, to be sweetly coldly harmonious, therefore the therapeutic method to keep the adverse QI flowing downwards and tonifying YIN, again can improving eyesight and cough-relieving, have the merit of tonification.Modern study proves, Folium Mori have the effects such as blood sugar lowering, life lengthening, blood fat reducing, scavenging activated oxygen, antiinflammatory and antiviral, these effect with control the modern disease such as human body chronic disease and hypertension, diabetes, atherosclerosis, obesity and life lengthening closely related.Ancient medicine claims Folium Mori to have the effect of " in appearance, black beard and hair ".Research in recent years confirms, the natural beauty treatment skin care good product that Folium Mori are inexpensive really, especially has good curative effect to the acne of face, brown macules, cyasma.Brainstrust is thought, takes Folium Mori so have good efficacy to skin brown macules, may with it to the improvement of body secretes function with there is effect of heat-clearing and toxic substances removing relevant, and Folium Mori can suppress the existence of intestinal toxic bacterial reproduction and peroxide, whole intestinal, detoxicating intestine.Prove according to pharmacological research, Folium Mori are rich in that flavone is made a mistake, the trace element of phenols, aminoacid, organic acid, carotene, vitamin and multiple needed by human, this is to improving and the metabolism of regulation of skin tissue, particularly suppresses Pigmented generation and develop all have positive role.
Euphorbia royleana Boiss. is euphorbia Euphorbia royleana Boiss., has another name called Buddha's warrior attendant pestle, cold water Jindan, and this plant Herb and milk are used as medicine according to records, tool dispels the wind, antiinflammatory, removing toxic substances effect.Record in " Kunming conventional medical herbs among the people " " dispel the wind, antiinflammatory, removing toxic substances.Control sore, tinea ".Research shows the secondary metabolite containing types such as phenolic constituent, diterpene, triterpene and steroidals in this plant.Bibliographical information Euphorbia royleana Boiss. ethyl acetate extract is had to have significantly anticorrosion, sterilization and the effect such as antiinflammatory.
At present, there is not yet the relevant report compositions of Herba Phyllanthi Urinariae, Radix Polygalae fallacis, Herba Hyperici Japonici, Herb Gynostemmae Pentaphylli, Herba Centellae, Herba Kalimeridis, Folium Mori and Euphorbia royleana Boiss. being used for the treatment of red blood trace on face both at home and abroad.
In sum, current red blood trace on face lacks effective external use skin care, beneficial effect of the present invention is the cause of disease according to red blood trace on face and pathomechanism, a large amount of monograph and document are consulted, successively screen multiple natural plants, finally filter out the pharmaceutical composition effectively can treating red blood trace on face.Drug regimen raw material of the present invention obtains simple, and preparation method is convenient.Clinical test results confirms: medicine composite for curing red blood trace on face effect of the present invention has good effect, to no skin irritation and sensitization, is easy to be accepted by consumers in general, has a good application prospect and market prospect.
Foregoing invention content part of the present invention has done detailed description to technical scheme of the present invention, and those skilled in the art can repeat the present invention according to foregoing and obtain technique effect of the present invention.Be further explained content of the present invention below by detailed description of the invention, to make those skilled in the art more clearly understand the present invention, not limitation of the present invention, any equivalent replacement or known change all belong to scope.
Detailed description of the invention
Embodiment 1
At room temperature, get Herba Phyllanthi Urinariae, Radix Polygalae fallacis, Herba Hyperici Japonici, Herb Gynostemmae Pentaphylli, Herba Centellae, Herba Kalimeridis, Folium Mori and each 10 kilograms of Euphorbia royleana Boiss. (totally 80 kilograms), with ethanol 800 kilograms of soak extraction of volumetric concentration 70%, soak time is 24 hours, residue soaks with the ethanol 800 kilograms of volumetric concentration 70% and extracts for 24 hours, then the solution after immersion is merged, after 200 object strainer filterings, concentrating under reduced pressure 20 times, again by macroporous resin on concentrated solution, with the ethanol elution of volumetric concentration 50%, containing effective ingredient required in prescription of the present invention in the eluent collected, i.e. pharmaceutical composition.
Embodiment 2
At room temperature, get Herba Phyllanthi Urinariae 8 kilograms, Radix Polygalae fallacis 8 kilograms, Herba Hyperici Japonici 8 kilograms, Herb Gynostemmae Pentaphylli 12 kilograms, Herba Centellae 12 kilograms, Herba Kalimeridis 12 kilograms, 12 kilograms, Folium Mori, Euphorbia royleana Boiss. 8 kilograms (totally 80 kilograms), with ethanol 800 kilograms of soak extraction of volumetric concentration 50%, soak time is 24 hours, residue soaks with the ethanol 800 kilograms of volumetric concentration 50% and extracts for 24 hours, then the solution after immersion is merged, after 200 object strainer filterings, concentrating under reduced pressure 40 times, again by macroporous resin on concentrated solution, with the ethanol elution of volumetric concentration 40%, containing effective ingredient required in prescription of the present invention in the eluent collected, i.e. pharmaceutical composition.
Embodiment 3
At room temperature, get Herba Phyllanthi Urinariae 8 kilograms, Radix Polygalae fallacis 8 kilograms, Herba Hyperici Japonici 15 kilograms, Herb Gynostemmae Pentaphylli 15 kilograms, Herba Centellae 15 kilograms, Herba Kalimeridis 15 kilograms, 15 kilograms, Folium Mori, Euphorbia royleana Boiss. 8 kilograms (totally 99 kilograms), with ethanol 1980 kilograms of soak extraction of volumetric concentration 80%, soak time is 24 hours, residue soaks with the ethanol 1980 kilograms of volumetric concentration 80% and extracts for 24 hours, then the solution after immersion is merged, 25 times are concentrated after 200 object strainer filterings, again by macroporous resin on concentrated solution, with the ethanol elution of volumetric concentration 60%, containing effective ingredient required in prescription of the present invention in the eluent collected, i.e. pharmaceutical composition.
Embodiment 4
At room temperature, get Herba Phyllanthi Urinariae 10 kilograms, Radix Polygalae fallacis 10 kilograms, Herba Hyperici Japonici 10 kilograms, Herb Gynostemmae Pentaphylli 12 kilograms, Herba Centellae 12 kilograms, Herba Kalimeridis 12 kilograms, 12 kilograms, Folium Mori, Euphorbia royleana Boiss. 8 kilograms (totally 86 kilograms), with ethanol 1500 kilograms of soak extraction of volumetric concentration 30%, soak time is 24 hours, residue soaks with the ethanol 1500 kilograms of volumetric concentration 30% and extracts for 24 hours, then the solution after immersion is merged, 50 times are concentrated after 200 object strainer filterings, again by macroporous resin on concentrated solution, with the ethanol elution of volumetric concentration 50%, containing effective ingredient required in prescription of the present invention in the eluent collected, i.e. pharmaceutical composition.
Embodiment 5
At room temperature, get Herba Phyllanthi Urinariae 8 kilograms, Radix Polygalae fallacis 8 kilograms, Herba Hyperici Japonici 8 kilograms, Herb Gynostemmae Pentaphylli 10 kilograms, accumulated snow removes from office 10 kilograms, Herba Kalimeridis 10 kilograms, 15 kilograms, Folium Mori, Euphorbia royleana Boiss. 10 kilograms (totally 79 kilograms), with ethanol 1200 kilograms of soak extraction of volumetric concentration 60%, soak time is 24 hours, residue soaks with the ethanol 1200 kilograms of volumetric concentration 60% and extracts for 24 hours, then the solution after immersion is merged, 30 times are concentrated after 200 object strainer filterings, again by macroporous resin on concentrated solution, with the ethanol elution of volumetric concentration 80%, containing effective ingredient required in prescription of the present invention in the eluent collected, i.e. pharmaceutical composition.
Embodiment 6
Liquid embodiment 1 obtained adopts concentrating under reduced pressure, is concentrated into 10% ~ 50% of original weight amount, obtains pharmaceutical composition concentrated solution, and for the preparation of the essence for the treatment of red blood trace on face, the percentage by weight of component is as follows:
Production technology: hyaluronate sodium is added to the water dispersed with stirring even, then adds other composition successively, stir in 70 DEG C of situations.
Present pre-ferred embodiments matrix components used is described above, and the present embodiment matrix components used can by the efficacy exertion of pharmaceutical composition of the present invention to the best.But the conventional substrate that can be applicable to cosmetics of other manufacturer production also can be used for the present invention, as long as consumption meets national cosmetic additive amount standard, can not affect effect of the present invention, therefore not enumerate.
The present invention's emulsifying equipment used is the FV-30L FISCO vacuum homogeneous emulsifying machine that Shanghai Frock Fluid Machinery Manufacture Co., Ltd. produces, and it has the functions such as homogenizing, stirring and temperature control.The emulsifying equipment prepared for cosmetics of other manufacturer production also may be used for the present invention, as long as operate in strict accordance with technological parameter of the present invention, all can reach effect of the present invention.
Embodiment 7
The clinical experimental study report of medicine composite for curing red blood trace on face: in following experiment, pharmaceutical composition used is the essence for the treatment of red blood trace on face prepared by the cosmetic formulations of embodiment 6.
1. materials and methods
The routine facial telangiectasias patient of case selection 168 of 1.1 red blood trace on face patients, from outpatient service, is women, 22 ~ 41 years old age, average out to 35 years old, the course of disease 8 months ~ 15 years, average 6.23 years.Skin lesion is mainly distributed in cheekbone portion, buccal and dilator naris, is non-essential telangiectasia patient, wherein cosmetics improper use person 72 example, improper person 51 example of aesthetic nursing, external skin drug-induced person 24 example, person 21 example caused by the reasons such as Exposure to Sunlight.Patient facial region has obvious telangiectasis, but without obvious atrophoderma, does not do the treatments such as laser, freezing, electrolysis.Be divided into treatment group (87 example) and matched group (81 is routine) at random, two groups in sex, age, the state of an illness without marked difference.
The essence containing pharmaceutical composition of the present invention of 1.2 Therapeutic Method treatment groups is provided by Zhong He International Technology company limited, according to a conventional method essence is applied in facial telangiectasias place, 3 times/day after clean face.Matched group: medical liquid paraffin is purchased from Shangqiu City Liang Feng hygienic article company limited (hygiene permits number: card No. 0024th, the word (2007) that disappears is defended in Henan), also be according to a conventional method liquid paraffin is applied in facial telangiectasias place, 3 times/day after clean face.Treat observe the curative effect after 60 days, carry out therapeutic evaluation, and record untoward reaction.
1.3. parameters for observation on effect and standards of grading: subjective symptom: the improvement standard scores of the tight sense of xerosis cutis, pruritus 4 grades: obviously improve, improve, slightly improve, without improving.Obvious improvement, improve number of cases and add up to improvement rate.Objective sign: the improvement standard of facial telangiectasias is divided into 4 grades, recovery from illness: telangiectasis is disappeared and reached 90% ~ 100%; Effective: telangiectasis is disappeared and reached 70% ~ 89%: effectively: telangiectasis disappears 30% ~ 69%; Invalid: telangiectasis is disappeared below 30% or without significant change.Effective percentage adds effective adding effectively in recovery from illness.
2. result
Two groups of subjective symptoms improve the skin of face tight sense of drying and the pruritus degree of situation comparison therapy group patient, and successful is better than matched group (P < 0.001, table 1), and difference has pole significant difference.
A table 1 liang group patient objective sign improves situation
Two groups of objective signs improve situation comparison therapy groups and matched group improving the curative effect in red blood trace on face patient objective sign pole significant difference (P < 0.001, table 1), the essence containing pharmaceutical composition of the present invention significantly can improve the facial telangiectasias of most patient.
A table 2 liang group patient objective sign improves situation
All there is not untoward reaction before and after Product Safety assessment treatment, come off without 1 routine patient.There is not the Adverse Event relevant to the essence containing pharmaceutical composition of the present invention in whole research process.
Adopt the pharmaceutical composition with the effect for the treatment of red blood trace on face of other embodiment to carry out clinical trial, result also proves to have identical effect.This illustrates that pharmaceutical composition of the present invention treats the desirable external use skin care of red blood trace on face at present, and its safety is good, untoward reaction is little, strong adaptability, is worthy of popularization.
Embodiment 8
The skin irritation test research report of pharmaceutical composition for the treatment of red blood trace on face: by animal experiment, observes local skin irritant reaction and anaphylaxis situation that the intact skin for the treatment of red blood trace on face pharmaceutical composition multiple-contact rabbit of the present invention and damaged skin produce.In following experiment, pharmaceutical composition used is the pharmaceutical composition of embodiment 1.
1 animal
16 regular grade adult healthy new zealand rabbits, male and female half and half, 2.5kg ~ 3.5kg, buys in Guangdong Medical Lab Animal Center, and laboratory animal production licence number is SCXK (Guangdong) 2008-0002, the animal quality certification number: Guangdong 2012A016.Raise in Animal House F4 room, general area, new southern Drug safety assessment center (the experimental animal room quality certification number: 0060590.), duration of test, room temperature 20 DEG C ~ 22 DEG C, humidity 40% ~ 67%, illumination 12h/12h round the clock light and shade replaces.
2 methods
(1) irritant test of intact skin: according to Ministry of Health of the People's Republic of China " cosmetics health specification (version in 2007) ", adopt consubstantiality self left and right sides matching type, prepare before administration: 24h before administration, employing is shaved mao method and is removed family's rabbit back spinal column both sides by hair, the left and right each about 3cm × 3cm of unhairing scope, application area 2.5cm × 2.5cm, not injured skin.Administration: in contrast, pharmaceutical composition (1.0g/ only) is smeared in unhairing district, back, right side to left side bare substrate (normal saline), earns gauze wrapping, after fixing 4h, clean medicine-feeding part with warm water with dry.Smear 1 every day, continuous 14d.Each remove medicine and again observe erythema and edema before coating, whether coating part has pigmentation, petechia, pachylosis or epidermatic atrophy situation and time of origin and regression time, and erythema and edema to be marked.After last coating, after removal medicine, 30-60min, 24h, 48h and 72h perusal is also recorded and is smeared position with or without the situation such as erythema, edema and pigmentation, petechia, skin emolliency.
(2) irritant test of damaged skin: according to Ministry of Health of the People's Republic of China " cosmetics health specification (version in 2007) ", adopt consubstantiality self left and right sides matching type, before test, 24h cuts off a rabbit back both sides fur, unhairing scope left and right each about 3cm × 3cm, application area 2.5cm × 2.5cm.With blade, standardized groined type is damaged gently, the degree of being with oozing of blood.Then in contrast, pharmaceutical composition (1.0g/ only) is smeared in unhairing district, back, right side, wraps up with clean gauze in left side bare substrate (normal saline) immediately, after fixing 4h, cleans medicine-feeding part with warm water.Smear 1 every day, continuous 14d.Each remove medicine and again observe erythema and edema before coating, whether coating part has pigmentation, petechia, pachylosis or epidermatic atrophy situation and time of origin and regression time, and erythema and edema to be marked.After last coating, after removal medicine, 30-60min, 24h, 48h and 72h perusal is also recorded and is smeared position with or without the situation such as erythema, edema and pigmentation, petechia, skin emolliency.
3 results
(1) irritant test of intact skin: the result of table 2 shows pharmaceutical composition of the present invention to rabbit intact skin nonirritant.Histopathologic examination's result of the test: matched group and pharmaceutical composition group rabbit skin epithelial cell form no abnormality seen, corium and subcutaneous tissue have no vasodilation and inflammatory cell infiltration and collagen fiber hyperplasia.
Show 31.0g/ pharmaceutical composition to rabbit intact skin stimulation
(2) irritant test of damaged skin: 16 rabbit of pharmaceutical composition group without erythema, without the situation such as edema, pigmentation (table 3).Histopathologic examination's result of the test: matched group and pharmaceutical composition group rabbit skin epithelial cell form no abnormality seen, corium and subcutaneous tissue have no vasodilation, have no obvious collagen fiber hyperplasia, visible mild inflammatory cellular infiltration.Therefore pharmaceutical composition of the present invention is to rabbit damaged skin nonirritant.
Show 41.0g/ pharmaceutical composition to rabbit damaged skin stimulation
Embodiment 10
The hypersensitive experimentation report of the pharmaceutical composition for the treatment of red blood trace on face: by animal experiment, observe treatment red blood trace on face pharmaceutical composition of the present invention to the sensitization of Hartley guinea pig skin.The pharmaceutical composition that the pharmaceutical composition used in this experiment is the embodiment of the present invention 1.
1 animal
Select regular grade Hartley Cavia porcellus 50, male and female half and half, weight range 180 ~ 250g, buy in Guangdong Medical Lab Animal Center, laboratory animal production licence number is SCXK (Guangdong) 2008-0002, the animal quality certification number: Guangdong 2012A064.Raise in Animal House F4 room, general area, new southern Drug safety assessment center (the experimental animal room quality certification number: 0060590.), duration of test, room temperature 20 DEG C ~ 22 DEG C, humidity 40% ~ 67%, illumination 121h/12h round the clock light and shade replaces.By number skin dyeing is carried out to Cavia porcellus, with saturated picric acid solution (yellow) dye marker units, with 2% silver nitrate solution (coffee color) dye marker tens; Separately raise by sex, each cage box puts 5 Cavia porcelluss, and cage box is outer labelled, indicates the information such as special topic numbering, animal category, group, sex, route of administration, cage number, number of animals and desired assay commencement date and deadline.The pharmaceutical composition that the pharmaceutical composition used in this experiment is the embodiment of the present invention 1, concentration is 1.0g medicine/only.
2 methods
According to country " drug registration management method ", " Chemical induced irritation, anaphylaxis and hemolytic investigative technique guideline ".Be divided into bare substrate group, positive controls, pharmaceutical composition group at random, wherein bare substrate group 10 Cavia porcelluss, all the other respectively organize 20 Cavia porcelluss.Each group of Cavia porcellus male and female half and half.Successively carry out induction sensitization and contact experiment with exciting, two test between be separated by eluting phase of 10 days.Induction exposure experimental technique is front 24h preserved skin, cut off each 2cm × 2cm region, Cavia porcellus spinal column both sides by hair.Positive controls: get 2.5%2, the acetone soln 0.2g of 4-dinitro-chloro-benzene, cover with two-layer gauze (2.5cm × 2.5cm) and one deck antistaling film respectively, 6h is covered with non-stimulated gauze, remove covering, remove residual given the test agent with warm water, the 7th day and the 14th day, in kind repeat once; Be coated with bare substrate 0.1g in bare substrate treated animal same area, pharmaceutical composition group is coated with 0.1g.Induction exposure is carried out by same step.Contact is excited to be then after last is to tested material sensitization contact 14 days (namely testing the 28th day), at the pharmaceutical composition of pharmaceutical composition group guinea pig back preserved skin place coating 0.1g, package is with fixing, tested material is removed after 6h, observe at once, then again observe skin allergy situation in 24h, 48h and 72h.The positive controls acetone soln 0.2g of 2.5%2,4-dinitro-chloro-benzene, bare substrate treated animal same area is coated with bare substrate 0.1g.1h, 24h and 24h, 48h and 72h observation administration local skin erythema, edema and other abnormal responses after exciting after sensitization.By skin allergy standards of grading, skin erythema and edema are marked, and calculate the anaphylaxis incidence rate of each group, judge anaphylaxis occurrence degree by skin hypersensitivity evaluation criterion.Anaphylaxis incidence rate=(occurring number of animals/this treated animal sum of skin erythema, edema or systemic anaphylaxis in group) × 100%.
3 results:
Excite the rear 24h of contact experiment, 48h and 72h, by not knowing that the professional of experiment content is according to " Chemical induced irritation, anaphylaxis and hemolytic investigative technique guideline " pass judgment on whether occur sensitization of skin reaction (table 4), sensitivity response scoring >=2 timesharing, judge that this animal skin sensitivity response is positive, calculate sensitization rate (>=2 points of number of animals/these treated animal sum × 100%), and by " Chemical induced irritation, anaphylaxis and hemolytic investigative technique guideline " in sensitization of skin reaction test grade scale judge the sensitization intensity (table 5) of pharmaceutical composition of the present invention to guinea pig skin.
Table 5 sensitization of skin extent of reaction standards of grading
Highest point total value 8
First calculate and put each group of integral mean value each observing time, then calculate and to observe in the time limit animal integral mean value every day every, evaluate by " Chemical induced irritation, anaphylaxis and hemolytic investigative technique guideline ".By following formulae discovery every animal average integral every day.
Table 6 sensitization of skin extent of reaction grade scale
Excite rear 24h, 48h and 72h, the Cavia porcellus of bare substrate group, pharmaceutical composition group excites area skin all not occur erythema, edema situation, also do not occur other abnormal response, anaphylaxis incidence rate is 0, and anaphylaxis evaluation is and has no skin allergy (table 6).
Excite rear 6h, 2,4-dinitro-chloro-benzene group Cavia porcellus excites area skin all to occur erythema, and anaphylaxis incidence rate is 100%, and anaphylaxis is evaluated as extremely strong sensitization.Excite rear 48h, 2,4-dinitro-chloro-benzene Cavia porcellus excites area skin still all to have erythema, and anaphylaxis incidence rate is 100%, and anaphylaxis evaluation is still extremely strong sensitization.
The anaphylaxis of table 7 pharmaceutical composition guinea pig skin is marked
4 conclusions
Under this experiment condition, pharmaceutical composition carries out 3 sensitization to Hartley guinea pig skin and has no skin allergy after exciting for 1 time.
Claims (9)
1. treat the pharmaceutical composition of red blood trace on face, it is characterized in that: with Herba Phyllanthi Urinariae, Radix Polygalae fallacis, Herba Hyperici Japonici, Herb Gynostemmae Pentaphylli, Herba Centellae, Herba Kalimeridis, Folium Mori and Euphorbia royleana Boiss. for prepared by raw material, and the weight percentage of any component is all no more than 30% of total amount.
2. treat the pharmaceutical composition of red blood trace on face, it is characterized in that, it is prepare with the raw material of following mass fraction: Herba Phyllanthi Urinariae 1 ~ 60 part, Radix Polygalae fallacis 1 ~ 60 part, Herba Hyperici Japonici 1 ~ 60 part, Herb Gynostemmae Pentaphylli 1 ~ 60 part, Herba Centellae 1 ~ 60 part, Herba Kalimeridis 1 ~ 60 part, 1 ~ 60 part, Folium Mori, Euphorbia royleana Boiss. 1 ~ 60 part.
3. the pharmaceutical composition for the treatment of red blood trace on face according to claim 2, it is characterized in that, it is prepare with the raw material of following mass fraction: Herba Phyllanthi Urinariae 1 ~ 50 part, Radix Polygalae fallacis 1 ~ 50 part, Herba Hyperici Japonici 1 ~ 50 part, Herb Gynostemmae Pentaphylli 1 ~ 50 part, Herba Centellae 1 ~ 50 part, Herba Kalimeridis 1 ~ 50 part, 1 ~ 50 part, Folium Mori, Euphorbia royleana Boiss. 1 ~ 50 part.
4., for the preparation method of the pharmaceutical composition of the treatment red blood trace on face described in any one of claims 1 to 3, it is characterized in that, comprise the following steps:
The first step: each above-mentioned raw material is placed in volumetric concentration be 20% ~ 80% ethanol soak, the ethanol consumption soaked is 10 ~ 200 times of each raw material gross weight, filters, obtains soak;
Second step: soak is concentrated into 2 ~ 5% of original weight amount, concentrated solution macroporous resin adsorption, then the ethanol elution using volumetric concentration 5 ~ 95%, collect eluent, be the pharmaceutical composition of described treatment red blood trace on face.
5. the preparation method of the pharmaceutical composition for the treatment of red blood trace on face according to claim 4, is characterized in that: in the first step, and the described soak with ethanol time is 2 ~ 48 hours; Or each raw material first uses soak with ethanol 2 ~ 48 hours, residue uses soak with ethanol 2 ~ 48 hours again, merges the solution after soaking, obtains soak.
6. the preparation method of the pharmaceutical composition for the treatment of red blood trace on face according to claim 4, is characterized in that: in second step, and the volumetric concentration of described eluting ethanol is 40% ~ 95%.
7. the purposes of the pharmaceutical composition of the treatment red blood trace on face according to any one of claims 1 to 3, is characterized in that: for the preparation of the curative drug of skin care cosmetics or skin.
8. skin care cosmetics, comprise the adjuvant that the black-eyed pharmaceutical composition for the treatment of described in any one of claims 1 to 3 and cosmetic field use.
9. the curative drug of skin, comprises the black-eyed pharmaceutical composition for the treatment of described in any one of claims 1 to 3 and medically acceptable carrier.
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN105963178A (en) * | 2016-05-15 | 2016-09-28 | 佛山市芊茹化妆品有限公司 | Cosmetic composition with function of removing red blood streaks |
| CN106397169A (en) * | 2016-04-22 | 2017-02-15 | 中国科学院昆明植物研究所 | Filicinic acid compounds, and pharmaceutical compositions and application thereof |
| CN107669751A (en) * | 2017-09-19 | 2018-02-09 | 广州青岚生物科技有限公司 | A kind of clarification process and method of quality control of the pharmaceutical composition that there is treatment red blood trace on face to act on |
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| JP2006124355A (en) * | 2004-11-01 | 2006-05-18 | Ichimaru Pharcos Co Ltd | Phagocytosis inhibitor |
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106397169A (en) * | 2016-04-22 | 2017-02-15 | 中国科学院昆明植物研究所 | Filicinic acid compounds, and pharmaceutical compositions and application thereof |
| CN105963178A (en) * | 2016-05-15 | 2016-09-28 | 佛山市芊茹化妆品有限公司 | Cosmetic composition with function of removing red blood streaks |
| CN105963178B (en) * | 2016-05-15 | 2018-08-31 | 广州京妍生物科技有限公司 | Has effects that the cosmetic composition of red blood silk |
| CN107669751A (en) * | 2017-09-19 | 2018-02-09 | 广州青岚生物科技有限公司 | A kind of clarification process and method of quality control of the pharmaceutical composition that there is treatment red blood trace on face to act on |
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