CN104545788B - A kind of motion feature based on eyeball real-time positioning system to Intraocular Tumor region - Google Patents
A kind of motion feature based on eyeball real-time positioning system to Intraocular Tumor region Download PDFInfo
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- CN104545788B CN104545788B CN201410856051.4A CN201410856051A CN104545788B CN 104545788 B CN104545788 B CN 104545788B CN 201410856051 A CN201410856051 A CN 201410856051A CN 104545788 B CN104545788 B CN 104545788B
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Abstract
The invention discloses a kind of motion feature based on eyeball localization method to Intraocular Tumor region, it comprises the following steps: extract anterior chamber of eye organizational information, to the calibration of anterior chamber of eye information and three-dimensionalreconstruction, obtain the shift parameters before and after ocular movement, build three-dimensional eyeball phantom based on CT image, set up the coordinate relation of anterior chamber of eye feature structure and intraocular tumour position；The present invention utilizes the anterior chamber of eye image that real-time tracing OCT obtains, then by the treatment technology such as image reconstruction and registration, it is accurately positioned tumor in radioactive area, the invention also discloses a kind of imaging device extracting eyeball anterior chamber of eye organizational information, it includes OCT light source, beam splitter, sample arm, reference arm and feedback device；This real time location tracking system belongs to external noinvasive location, can reach to improve Position location accuracy, the radiological dose drawn game control rate of raising ocular tumor, and the purpose such as the radiological dose of minimizing surrounding normal and damage.
Description
Technical field
The present invention relates to what eyeball specific region was positioned by a kind of motion feature based on eyeball
Method, a kind of uses Optical coherence tomography to position eyeball
Method and the imaging device of extraction anterior chamber of eye organizational information.
Background technology
Radiotherapy is one of important means to ocular tumor, in particular for as black in choroid
Element tumor, retinoblastoma, Pediatric Rhabdomyosarcoma, Intraocular lymphoma and tunica uvea are black
The tumors such as element tumor.The radiation that tumor target is sufficiently large is given by accurate external exposure radiation technique
Dosage, and evade the normal structure of periphery (depending on god at tumor peripheries by precipitous dose gradient
Warp, speckle, corpus ciliare and crystal) damaged, improve the accurate radiation of tumor target, thus
Effectively protect vision and the normal function of eyeball of ocular tumor patient.
But no matter use which kind of external exposure technology, the usefulness pole to the radiation of ocular tumor target area
The earth depends on patient and puts the accuracy of position and enforcement.Human eyeball is because of without autonomic movement, it is impossible to
Being completely fixed, yet with the precipitous dose gradient characteristic of accurate radiation technique, eyeball is the least
One, without autonomic movement, all may cause the high dose area originally planned to fall normal surrounding tissue
On, cause the overtreatment of the unacceptable low dosage in tumor area and normal surrounding tissue and organ to shine
Penetrate.As can be seen here, due to the specificity of eye motion, ocular tumor location and and radiation area thereof
Between territory, deviation effectively revises the effect to protection eyeball normal structure and swells to improving eye
The radiation usefulness of tumor target area is most important.
Although eyes spherical, quickly movement being fixed the most relatively difficult, but people being also
Attempt the fixing means of multiple eyeball, such as eyeball adsorption plant, rear eyeball or eyeball periphery
Anesthesia, or automatically fixing etc. the method for point source.But, above-mentioned eyeball adsorption plant can cause
The Uncomfortable feeling that patient is the biggest, and it is likely to result in front ophthalmic injuries；And local anesthesia also can give disease
People brings sense of discomfort, and may induction eyeball dislocation in socket of the eye.At present, ocular tumor is accurate
Radiotherapy technology, such as proton radiotherapy etc., up-to-date location mode is by there being traumatic operation to put
Put light tight chip, come the position of the most really ocular tumor.Every time before radiotherapy, pass through multi-angle
Shooting spacer, determine relation between light tight chip and the coordinate of plan to determine tumor and
The position relationship in radioactive area.But, this light tight chip positioning depending on operation placement
Accurate radiotherapy is made to become the therapeutic modality of a kind of invasive, and, the placement of chip needs relatively
High surgical skill, and there is the hemorrhage or danger of scleral perforation.Additionally, plant outer gold
Belong to chip on other occasions, it is also possible to form dosage shadow region, cause tumor dose not
Foot, affects office's control rate of tumor.Based on this present situation, need the most in a hurry to develop noinvasive
, the aided positioning system in the radioactive area positioning ocular tumor quickly and accurately, to realize
Radiotherapy to intraocular tumour adaptivity, reduces the radiation injury of eyeball.
Summary of the invention
In order to overcome the deficiencies in the prior art, the invention provides a kind of motion based on eyeball special
Levying the alignment system to Intraocular Tumor region, this alignment system can be special according to the motion of eyeball
Levy, obtain eyeball and move parameter, the relative coordinate position respectively organized according to tumor locus and anterior chamber of eye
Put relation, the most accurately and non-invasively position the radioactive area of ocular tumor.
To achieve these goals, the technical solution used in the present invention is: a kind of based on eyeball
The motion feature localization method to Intraocular Tumor region, it is characterised in that comprise the following steps:
Extract anterior chamber of eye organizational information, to the calibration of anterior chamber of eye information and three-dimensionalreconstruction, obtain ocular movement
Shift parameters front and back, builds three-dimensional eyeball phantom, sets up anterior chamber of eye feature structure and swells with ophthalmic
The coordinate relation at tumor position,
1. the extraction of anterior chamber of eye organizational information: obtain anterior chamber of eye organization charts picture by OCT, uses base
Shortest path first's algorithm in dynamic programming automatically extracts, and this anterior chamber of eye tissue includes angle
Film, iris, sclera, pupil, crystalline lens,
2. image calibration: based on the Snell's law method by three-dimensional vector ray tracing
Correct the deformation of D S D-OCT image, reduce each refractive interface of full eye real physics chi
It is very little,
3. anterior chamber of eye three-dimensionalreconstruction: according to the rectification rear interface information 2. walking acquisition, determine successively
Anterior surface of cornea border, posterior surface of cornea border, pupil, crystalline lens front surface border, crystalline substance
Border, shape body rear surface, is optimized the above-mentioned boundary interface extracted according to pupil position and joins
Standard, sets up anterior chamber of eye threedimensional model based on OCT image mode after image registration,
4. shift parameters before and after ocular movement is obtained: according to the above-mentioned steps 3. middle three-dimensional mould set up
Type, on the basis of the image of initial time, uses image registration algorithm, obtains ocular movement
The shift parameters caused, shift parameters uses the 6 dimension coordinate systems comprising translation and rotation to carry out table
Show,
5. three-dimensional eyeball phantom is built: according to the knub position structure in CT view data and CT image
Build three-dimensional eyeball phantom,
6. coordinate system is set up: by the anterior chamber of eye threedimensional model based on OCT image mode obtained and base
Three-dimensional eyeball phantom in CT image carries out proportioning, sets up anterior chamber of eye feature structure after registration
Coordinate relation with intraocular tumour position.
Another object of the present invention, it is provided that a kind of Motion feature extraction eyeball based on eyeball
The imaging device of anterior chamber of eye organizational information, it is characterised in that: include OCT light source, beam splitter,
Feedback device, described light source uses the near-infrared swept light source of 1.06 μm, and this swept light source is led to
Being connected with fiber splitter after crossing isolator isolation, fiber splitter has two outfans, should
Two outfans are connected to reference arm assembly and sample arm assembly, fiber splitter have with
The feedback end of reference arm assembly feedback link, reference arm assembly includes defeated with fiber splitter first
Go out end connect collimating mirror, collimating mirror connect have lens and reflecting mirror, sample arm assembly include with
The circulator that fiber splitter the second outfan connects, this circulator has outfan and feedback
End, the outfan of this circulator connects collimating mirror, scanning galvanometer, condenser lens and reflective
Mirror, described feedback device includes fiber coupler, the feedback end of fiber splitter and circulator
Feedback end be all connected with the input of fiber coupler, the outfan of fiber coupler connects to be had
Balanced detector.
Using such scheme, the present invention utilizes the anterior chamber of eye image that real-time tracing OCT obtains, so
Afterwards by the treatment technology such as image reconstruction and registration, it is accurately positioned tumor in radioactive area, should
Real time location tracking system belongs to external noinvasive location, can reach to improve Position location accuracy, carry
The radiological dose drawn game control rate of high ocular tumor, and reduce radiological dose and the damage of surrounding normal
The purposes such as wound.
The invention will be further described below in conjunction with the accompanying drawings.
Accompanying drawing explanation
Accompanying drawing 1 is the system framework of the imaging device of specific embodiment of the invention anterior chamber of eye tissue
Figure.
Detailed description of the invention
The specific embodiment of the present invention is Motion feature extraction eyeball based on eyeball as shown in Figure 1
The imaging device of anterior chamber of eye organizational information, including OCT light source, beam splitter, feedback device, light
Source uses the near-infrared swept light source of 1.06 μm, this swept light source isolated by isolator after with
50: 50 fiber splitters connect, and fiber splitter has two outfans, these two outfans
Being connected to reference arm assembly and sample arm assembly, fiber splitter has and reference arm assembly
The feedback end of feedback link, reference arm assembly includes being connected with fiber splitter the first outfan
Collimating mirror, collimating mirror connects has lens and reflecting mirror, sample arm assembly to include and fiber splitter
The circulator that second outfan connects, this circulator has outfan and feedback end, this circulator
Outfan connect have collimating mirror, scanning galvanometer, condenser lens and illuminator, feedback device bag
Include fiber coupler, the feedback end of fiber splitter and the feedback end of circulator all with optical fiber coupling
The input of clutch connects, and the outfan of fiber coupler connects balanced detector.Above-mentioned sweep
Frequently light source OCT uses the near-infrared swept light source of 1.06 μm, and light source is through 50: 50 optical fibre light splittings
After, enter reference arm and sample arm.Enter the light of reference arm through feeding back to fiber splitter
And enter fiber coupler, enter the light of sample arm, after tilted-putted mirror reflection
Imaging light is made to enter radiotherapy eye.The light coupling returned from reference arm and sample arm is interfered,
Export after balanced detector detects, obtain eye image.
The motion feature based on the eyeball real-time location method to Intraocular Tumor region, it include with
Lower step: extract anterior chamber of eye organizational information, to the calibration of anterior chamber of eye information and three-dimensionalreconstruction, obtains
Shift parameters before and after ocular movement, builds three-dimensional eyeball phantom, sets up anterior chamber of eye feature structure
With the coordinate relation at intraocular tumour position,
1. the extraction of anterior chamber of eye organizational information: obtain anterior chamber of eye organization charts picture by OCT, uses base
Shortest path first's algorithm in dynamic programming automatically extracts, and this anterior chamber of eye tissue includes angle
Film, iris, sclera, pupil, crystalline lens,
2. frame calibration: based on Snell's law by three-dimensional vector ray tracing
Method corrects the deformation of D S D-OCT image, reduces the full eye real thing of each refractive interface
Reason size,
3. anterior chamber of eye three-dimensionalreconstruction: according to the rectification rear interface information 2. walking acquisition, determine successively
Anterior surface of cornea border, posterior surface of cornea border, pupil, crystalline lens front surface border, crystalline substance
Border, shape body rear surface, is optimized the above-mentioned boundary interface extracted according to pupil position and joins
Standard, sets up anterior chamber of eye threedimensional model based on OCT image mode after image registration,
4. shift parameters before and after ocular movement is obtained: according to the above-mentioned steps 3. middle three-dimensional mould set up
Type, on the basis of the image of initial time, uses image registration algorithm, obtains ocular movement
The shift parameters caused, shift parameters uses the 6 dimension coordinate systems comprising translation and rotation to carry out table
Show,
5. three-dimensional eyeball phantom is built: according to the knub position structure in CT view data and CT image
Build three-dimensional eyeball phantom,
6. coordinate system is set up: by the anterior chamber of eye threedimensional model based on OCT image mode obtained and base
Three-dimensional eyeball phantom in CT image carries out proportioning, sets up anterior chamber of eye feature structure after registration
Coordinate relation with intraocular tumour position.
Said method also includes the checking of the accuracy of the most oculomotor shift parameters: intend employing one
Isolated model eye, and be fixed on sextuple regulating platform, this sextuple regulating platform can be simulated
The rotation of eyeball and translation.The above-mentioned frequency domain OCT developed voluntarily is used to gather isolated model eye
Rotate the anterior chamber of eye image after peace lead, obtain Eyeball dislocation parameter by said method,
And compare with actual parameter, verify the accuracy of carried algorithm with this.
The present invention utilizes the anterior chamber of eye image that real-time tracing OCT obtains, and then passes through image reconstruction
With treatment technologies such as registrations, it is accurately positioned tumor in radioactive area, this real time location tracking system
Subordination positions in external noinvasive, can reach to improve Position location accuracy, improve putting of ocular tumor
Penetrate dosage drawn game control rate, and the purpose such as the radiological dose of minimizing surrounding normal and damage.
Claims (1)
1. the motion feature based on an eyeball localization method to Intraocular Tumor region, its feature exists
In, comprise the following steps: extract anterior chamber of eye organizational information, to the calibration of anterior chamber of eye information and three-dimensionalreconstruction,
Obtain the shift parameters before and after ocular movement, build three-dimensional eyeball phantom, set up anterior chamber of eye feature structure
Coordinate relation with intraocular tumour position；
1. the extraction of anterior chamber of eye organizational information: obtain anterior chamber of eye organization charts picture by OCT, uses base
Shortest path first's algorithm in dynamic programming automatically extracts, this anterior chamber of eye tissue include cornea, iris,
Sclera, pupil, crystalline lens；
2. image calibration: rectified by the method for three-dimensional vector ray tracing based on Snell's law
The deformation of positive D S D-OCT image, reduces the full eye real physical size of each refractive interface；
3. anterior chamber of eye three-dimensionalreconstruction: according to the rectification rear interface information 2. walking acquisition, determine angle successively
Table after film front surface border, posterior surface of cornea border, pupil, crystalline lens front surface border, crystalline lens
Border, face, is optimized registration according to pupil position, after image registration by the above-mentioned boundary interface extracted
Set up anterior chamber of eye threedimensional model based on OCT image mode；
4. shift parameters before and after ocular movement is obtained: according to the above-mentioned steps 3. middle threedimensional model set up,
On the basis of the image of initial time, use image registration algorithm, obtain the displacement that ocular movement causes
Parameter；Shift parameters uses the 6 dimension coordinate systems comprising translation and rotation to represent；
5. three-dimensional eyeball phantom is built: according to the knub position structure in CT view data and CT image
Build three-dimensional eyeball phantom；
6. coordinate system is set up: by the anterior chamber of eye threedimensional model based on OCT image mode obtained and base
Three-dimensional eyeball phantom in CT image carries out proportioning, sets up anterior chamber of eye feature structure and ophthalmic after registration
The coordinate relation of tumor locus.
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| CN106137131A (en) * | 2016-07-18 | 2016-11-23 | 山东省肿瘤防治研究院 | A kind of noinvasive tumor-localizing system |
| CN106166058B (en) * | 2016-08-04 | 2019-05-28 | 温州医科大学 | One kind being applied to optical coherence tomography blood vessel imaging method and OCT system |
| CN106420110A (en) * | 2016-08-24 | 2017-02-22 | 滕植鑫 | Pediatric intraocular lens degree prediction method |
| CN107875526B (en) * | 2017-11-27 | 2020-01-24 | 温州医科大学附属第一医院 | Accurate control method of radiotherapy instrument in self-adaptive radiotherapy of eye tumor |
| CN107953037A (en) * | 2017-12-12 | 2018-04-24 | 佛山科学技术学院 | A kind of high-precision laser three dimensional sculpture device and method based on frequency sweep OCT |
| JP2021515191A (en) * | 2018-03-01 | 2021-06-17 | アルコン インコーポレイティド | Common path waveguide for stable optical coherence tomography |
| CN109045489B (en) * | 2018-08-22 | 2021-05-14 | 北京博纵科技有限公司 | Adjustable ultrasonic beauty imaging system for deep skin and acquisition method thereof |
| CN109875680B (en) * | 2019-02-18 | 2020-10-16 | 清华大学 | Common-path intelligent optical diagnosis and treatment system based on optical coherence tomography |
| CN113469936B (en) * | 2021-05-08 | 2023-10-03 | 温州医科大学 | Human eye cataract detection system and three-dimensional model image reconstruction method of crystalline lens |
| CN114373216A (en) * | 2021-12-07 | 2022-04-19 | 图湃(北京)医疗科技有限公司 | Eye movement tracking method, device, equipment and storage medium for anterior segment OCTA |
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| CN104013383A (en) * | 2014-06-04 | 2014-09-03 | 南京航空航天大学 | Bifocal anterior segment and posterior segment synchronous imaging system and imaging method |
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