CN104545788A - Eyeball tumor area real-time positioning system based on motion features of eyeball - Google Patents
Eyeball tumor area real-time positioning system based on motion features of eyeball Download PDFInfo
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- CN104545788A CN104545788A CN201410856051.4A CN201410856051A CN104545788A CN 104545788 A CN104545788 A CN 104545788A CN 201410856051 A CN201410856051 A CN 201410856051A CN 104545788 A CN104545788 A CN 104545788A
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Abstract
The invention discloses an eyeball tumor area real-time positioning method based on motion features of an eyeball. The eyeball tumor area real-time positioning method comprises the following steps of extracting an eye anterior-segment tissue information, conducting calibration and three-dimensional reconstruction on the eye anterior-segment tissue information to obtain shifting parameters before and after eyeball motion, establishing a three-dimensional eyeball model based on a CT image, and establishing the coordinate relation between an eye anterior segment feature structure and an intraocular tumor position. According to the eyeball tumor area real-time positioning method, an anterior-segment image obtained through real-time OCT tracking is utilized, and then the tumor is accurately positioned in a radiation area through processing technologies including image reconstruction, registering and the like. The invention further discloses an imaging device for extracting the eye anterior-segment tissue information. The imaging device for extracting the eye anterior-segment tissue information comprises an OCT light source, a beam splitter, a sample arm, a reference arm and a feedback device. A real-time positioning tracking system provides in-vitro noninvasive positioning and can achieve the purposes of improving positioning accuracy and radiation dose and local control rate of the ocular tumor, decreasing surrounding normal radiation dose and injury and the like.
Description
Technical field
The present invention relates to a kind of method eyeball specific region positioned based on the motion feature of eyeball, especially a kind of method adopting Optical coherence tomography to position eyeball and the imaging device extracting anterior chamber of eye organizational information.
Background technology
Radiotherapy is to one of important means of ocular tumor, especially for such as choroidal melanoma, and retinoblastoma, Pediatric Rhabdomyosarcoma, the tumor such as Intraocular lymphoma and uveal melanoma.Give tumor target enough large radiological dose by accurate external exposure radiation technique; and evade the normal structure (optic nerve of periphery at tumor peripheries by precipitous dose gradient; speckle; corpus ciliare and crystal) damaged; improve the accurate radiation of tumor target, thus effectively protect the vision of ocular tumor patient and the normal function of eyeball.
But no matter adopt which kind of external exposure technology, the accuracy that patient puts position and enforcement is greatly depended on to the usefulness of the radiation of ocular tumor target area.Human eyeball is because of without autonomic movement, cannot be completely fixed, but due to the precipitous dose gradient characteristic of accurate radiation technique, very little one of eyeball is without autonomic movement, the high dose area of original plan all may be caused to fall on normal surrounding tissue, cause the overtreatment of the unacceptable low dosage in tumor area and normal surrounding tissue and organ to irradiate.As can be seen here, due to the specificity of eye motion, ocular tumor location and and radioactive area between effective correction of deviation to protecting the effect of eyeball normal structure and all most important to the radiation usefulness improving ocular tumor target area.
Although be fixed just more difficult to eyes that are spherical, movement fast, people have also attempted the fixing means of multiple eyeball, as eyeball adsorption plant, and the anesthesia of rear eyeball or eyeball periphery, or point source to fix etc. method automatically.But, above-mentioned eyeball adsorption plant can cause the very large Uncomfortable feeling of patient, and may cause front ophthalmic injuries; And local anesthesia also can bring sense of discomfort to patient, and the dislocation of eyeball in socket of the eye may be brought out.At present, ocular tumor accurate radiotherapy technology, as proton radiotherapy etc., up-to-date locate mode is by there being traumatic operation to place light tight chip, comes the position of really ocular tumor indirectly.Before each radiotherapy, by multi-angled shooting spacer, determine that relation between light tight chip and the coordinate of plan is to determine the position relationship of tumor and radioactive area.But this light tight chip positioning depending on operation placement makes accurate radiotherapy become a kind of therapeutic modality having wound, and the placement of chip needs higher surgical skill, and there is danger that is hemorrhage or scleral perforation.In addition, plant outer metal chip on other occasions, also likely forming agent amount shadow region, cause tumor dose not enough, affect office's control rate of tumor.Based on this present situation, needing in a hurry clinically to develop noninvasive, to locate the radioactive area of ocular tumor quickly and accurately aided positioning system, to realizing the radiotherapy to intraocular tumour adaptivity, reducing the radiation injury of eyeball.
Summary of the invention
In order to overcome the deficiencies in the prior art, the invention provides a kind of motion feature based on eyeball to the navigation system in Intraocular Tumor region, this navigation system can according to the motion feature of eyeball, obtain eyeball and move parameter, according to the relative coordinate position relationship that tumor locus and anterior chamber of eye are respectively organized, fast accurately and non-invasively locate the radioactive area of ocular tumor.
To achieve these goals, the technical solution used in the present invention is: a kind of motion feature based on eyeball is to the localization method in Intraocular Tumor region, it is characterized in that, comprise the following steps: extract anterior chamber of eye organizational information, to the calibration of anterior chamber of eye information and three-dimensionalreconstruction, obtain the shift parameters before and after ocular movement, build three-dimensional eyeball phantom, set up the coordinate relation at anterior ocular segment feature structure and intraocular tumour position
1. the extraction of anterior chamber of eye organizational information: obtain anterior chamber of eye tissue image by OCT, adopt the shortest path first's algorithm based on dynamic programming automatically to extract, this anterior chamber of eye tissue comprises cornea, iris, sclera, pupil, crystalline lens,
2. image calibration: the distortion of being corrected D S D-OCT image based on Snell's law by the method for three-dimensional vector ray tracing, reduces the real physical size of each refractive interface of full eye,
3. anterior ocular segment three-dimensionalreconstruction: the rectification rear interface information 2. walking acquisition according to, determine anterior surface of cornea border, posterior surface of cornea border, pupil, crystalline lens front surface border, border, crystalline lens rear surface successively, the above-mentioned boundary interface extracted is optimized registration according to pupil position, the anterior ocular segment threedimensional model based on OCT image mode is set up after image registration
4. shift parameters before and after ocular movement is obtained: according to the above-mentioned steps 3. middle threedimensional model set up, with the image of initial time for benchmark, adopt image registration algorithm, obtain the shift parameters that ocular movement causes, shift parameters adopts the 6 dimension coordinate systems comprising translation and rotation to represent
5. three-dimensional eyeball phantom is built: build three-dimensional eyeball phantom according to the knub position in CT view data and CT image,
6. coordinate system is set up: the anterior ocular segment threedimensional model based on OCT image mode obtained and the three-dimensional eyeball phantom based on CT image are carried out proportioning, after registration, sets up the coordinate relation at anterior ocular segment feature structure and intraocular tumour position.
Another object of the present invention, provide a kind of imaging device of the Motion feature extraction eyeball anterior chamber of eye organizational information based on eyeball, it is characterized in that: comprise OCT light source, beam splitter, feedback device, described light source adopts the near-infrared swept light source of 1.06 μm, this swept light source is by being connected with fiber splitter after isolator isolation, fiber splitter has two outfans, these two outfans are connected to reference arm assembly and sample arm assembly, fiber splitter has the feedback end with reference arm assembly feedback link, reference arm assembly comprises the collimating mirror be connected with fiber splitter first outfan, collimating mirror is connected with lens and reflecting mirror, sample arm assembly comprises the circulator be connected with fiber splitter second outfan, this circulator has outfan and feedback end, the outfan of this circulator is connected with collimating mirror, scanning galvanometer, condenser lens and illuminator, described feedback device comprises fiber coupler, the feedback end of fiber splitter and the feedback end of circulator are all connected with the input of fiber coupler, the outfan of fiber coupler is connected with balanced detector.
Adopt such scheme, the anterior segment image that the present invention utilizes real-time tracing OCT to obtain, then by the treatment technology such as image reconstruction and registration, accurate positioning tumor is in radioactive area, this real time location tracking system belongs to external noinvasive location, the radiological dose drawn game control rate improving Position location accuracy, improve ocular tumor can be reached, and the object such as the radiological dose of minimizing surrounding normal and damage.
Below in conjunction with accompanying drawing, the invention will be further described.
Accompanying drawing explanation
Accompanying drawing 1 is the system framework figure of the imaging device of specific embodiment of the invention anterior chamber of eye tissue.
Detailed description of the invention
Specific embodiments of the invention are the imaging device of the Motion feature extraction eyeball anterior chamber of eye organizational information based on eyeball as shown in Figure 1, comprise OCT light source, beam splitter, feedback device, light source adopts the near-infrared swept light source of 1.06 μm, this swept light source is by being connected with 50:50 fiber splitter after isolator isolation, fiber splitter has two outfans, these two outfans are connected to reference arm assembly and sample arm assembly, fiber splitter has the feedback end with reference arm assembly feedback link, reference arm assembly comprises the collimating mirror be connected with fiber splitter first outfan, collimating mirror is connected with lens and reflecting mirror, sample arm assembly comprises the circulator be connected with fiber splitter second outfan, this circulator has outfan and feedback end, the outfan of this circulator is connected with collimating mirror, scanning galvanometer, condenser lens and illuminator, feedback device comprises fiber coupler, the feedback end of fiber splitter and the feedback end of circulator are all connected with the input of fiber coupler, the outfan of fiber coupler is connected with balanced detector.Above-mentioned swept light source OCT adopts the near-infrared swept light source of 1.06 μm, and light source, after 50:50 optical fibre light splitting, enters reference arm and sample arm.The light entering reference arm, through feeding back to fiber splitter and entering fiber coupler, enters the light of sample arm, makes imaging light enter radiotherapy eye after tilted-putted mirror reflection.The coupling light returned from reference arm and sample arm is interfered, and exports, obtain eye image after balanced detector detection.
Based on the motion feature of eyeball to the real-time location method in Intraocular Tumor region, it comprises the following steps: extract anterior chamber of eye organizational information, to the calibration of anterior chamber of eye information and three-dimensionalreconstruction, obtain the shift parameters before and after ocular movement, build three-dimensional eyeball phantom, set up the coordinate relation at anterior ocular segment feature structure and intraocular tumour position
1. the extraction of anterior chamber of eye organizational information: obtain anterior chamber of eye tissue image by OCT, adopt the shortest path first's algorithm based on dynamic programming automatically to extract, this anterior chamber of eye tissue comprises cornea, iris, sclera, pupil, crystalline lens,
2. frame calibration: based on the distortion of Snell's law by the method for three-dimensional vector ray tracing rectification D S D-OCT image, reduces the real physical size of each refractive interface of full eye,
3. anterior ocular segment three-dimensionalreconstruction: the rectification rear interface information 2. walking acquisition according to, determine anterior surface of cornea border, posterior surface of cornea border, pupil, crystalline lens front surface border, border, crystalline lens rear surface successively, the above-mentioned boundary interface extracted is optimized registration according to pupil position, the anterior ocular segment threedimensional model based on OCT image mode is set up after image registration
4. shift parameters before and after ocular movement is obtained: according to the above-mentioned steps 3. middle threedimensional model set up, with the image of initial time for benchmark, adopt image registration algorithm, obtain the shift parameters that ocular movement causes, shift parameters adopts the 6 dimension coordinate systems comprising translation and rotation to represent
5. three-dimensional eyeball phantom is built: build three-dimensional eyeball phantom according to the knub position in CT view data and CT image,
6. coordinate system is set up: the anterior ocular segment threedimensional model based on OCT image mode obtained and the three-dimensional eyeball phantom based on CT image are carried out proportioning, after registration, sets up the coordinate relation at anterior ocular segment feature structure and intraocular tumour position.
Said method also comprises the checking of the accuracy of 7. oculomotor shift parameters: intend employing one isolated model eye, and be fixed on sextuple regulating platform, this sextuple regulating platform can simulate rotation and the translation of eyeball.Anterior segment image after adopting the above-mentioned frequency domain OCT collection isolated model eye developed voluntarily to rotate peaceful lead, obtains Eyeball dislocation parameter by said method, and compares with actual parameter, verify the accuracy of carried algorithm with this.
The anterior segment image that the present invention utilizes real-time tracing OCT to obtain, then by the treatment technology such as image reconstruction and registration, accurate positioning tumor is in radioactive area, this real time location tracking system belongs to external noinvasive location, the radiological dose drawn game control rate improving Position location accuracy, improve ocular tumor can be reached, and the object such as the radiological dose of minimizing surrounding normal and damage.
Claims (2)
1. one kind based on the motion feature of eyeball to the localization method in Intraocular Tumor region, it is characterized in that, comprise the following steps: extract anterior chamber of eye organizational information, to the calibration of anterior chamber of eye information and three-dimensionalreconstruction, obtain the shift parameters before and after ocular movement, build three-dimensional eyeball phantom, set up the coordinate relation at anterior ocular segment feature structure and intraocular tumour position
1. the extraction of anterior chamber of eye organizational information: obtain anterior chamber of eye tissue image by OCT, adopt the shortest path first's algorithm based on dynamic programming automatically to extract, this anterior chamber of eye tissue comprises cornea, iris, sclera, pupil, crystalline lens,
2. image calibration: the distortion of being corrected D S D-OCT image based on Snell's law by the method for three-dimensional vector ray tracing, reduces the real physical size of each refractive interface of full eye,
3. anterior ocular segment three-dimensionalreconstruction: the rectification rear interface information 2. walking acquisition according to, determine anterior surface of cornea border, posterior surface of cornea border, pupil, crystalline lens front surface border, border, crystalline lens rear surface successively, the above-mentioned boundary interface extracted is optimized registration according to pupil position, the anterior ocular segment threedimensional model based on OCT image mode is set up after image registration
4. shift parameters before and after ocular movement is obtained: according to the above-mentioned steps 3. middle threedimensional model set up, with the image of initial time for benchmark, adopt image registration algorithm, obtain the shift parameters that ocular movement causes, shift parameters adopts the 6 dimension coordinate systems comprising translation and rotation to represent
5. three-dimensional eyeball phantom is built: build three-dimensional eyeball phantom according to the knub position in CT view data and CT image,
6. coordinate system is set up: the anterior ocular segment threedimensional model based on OCT image mode obtained and the three-dimensional eyeball phantom based on CT image are carried out proportioning, after registration, sets up the coordinate relation at anterior ocular segment feature structure and intraocular tumour position.
2. the imaging device based on the Motion feature extraction eyeball anterior chamber of eye organizational information of eyeball, it is characterized in that: comprise OCT light source, beam splitter, feedback device, described light source adopts the near-infrared swept light source of 1.06 μm, this swept light source is by being connected with fiber splitter after isolator isolation, fiber splitter has two outfans, these two outfans are connected to reference arm assembly and sample arm assembly, fiber splitter has the feedback end with reference arm assembly feedback link, reference arm assembly comprises the collimating mirror be connected with fiber splitter first outfan, collimating mirror is connected with lens and reflecting mirror, sample arm assembly comprises the circulator be connected with fiber splitter second outfan, this circulator has outfan and feedback end, the outfan of this circulator is connected with collimating mirror, scanning galvanometer, condenser lens and illuminator, described feedback device comprises fiber coupler, the feedback end of fiber splitter and the feedback end of circulator are all connected with the input of fiber coupler, the outfan of fiber coupler is connected with balanced detector.
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| CN106166058A (en) * | 2016-08-04 | 2016-11-30 | 温州医科大学 | One is applied to optical coherence tomography blood vessel imaging method and OCT system |
| CN106420110A (en) * | 2016-08-24 | 2017-02-22 | 滕植鑫 | Pediatric intraocular lens degree prediction method |
| CN107875526A (en) * | 2017-11-27 | 2018-04-06 | 温州医科大学附属第医院 | The accurate control method of radiotherapy instrument during a kind of ocular tumor adaptive radiation therapy |
| CN107953037A (en) * | 2017-12-12 | 2018-04-24 | 佛山科学技术学院 | A kind of high-precision laser three dimensional sculpture device and method based on frequency sweep OCT |
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| CN111819417A (en) * | 2018-03-01 | 2020-10-23 | 爱尔康公司 | Common-path waveguide for stabilizing optical coherence tomography imaging |
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| CN106137131A (en) * | 2016-07-18 | 2016-11-23 | 山东省肿瘤防治研究院 | A kind of noinvasive tumor-localizing system |
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| CN106420110A (en) * | 2016-08-24 | 2017-02-22 | 滕植鑫 | Pediatric intraocular lens degree prediction method |
| CN107875526A (en) * | 2017-11-27 | 2018-04-06 | 温州医科大学附属第医院 | The accurate control method of radiotherapy instrument during a kind of ocular tumor adaptive radiation therapy |
| CN107875526B (en) * | 2017-11-27 | 2020-01-24 | 温州医科大学附属第一医院 | Accurate control method of radiotherapy instrument in self-adaptive radiotherapy of eye tumor |
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| CN109045489A (en) * | 2018-08-22 | 2018-12-21 | 北京博纵科技有限公司 | A kind of adjustable supersonic beauty imaging system and its acquisition method for deep skin |
| CN109045489B (en) * | 2018-08-22 | 2021-05-14 | 北京博纵科技有限公司 | Adjustable ultrasonic beauty imaging system for deep skin and acquisition method thereof |
| CN109875680A (en) * | 2019-02-18 | 2019-06-14 | 清华大学 | Total optical path intelligent optical diagnosis and therapy system based on optical-coherence tomography |
| CN109875680B (en) * | 2019-02-18 | 2020-10-16 | 清华大学 | Common-path intelligent optical diagnosis and treatment system based on optical coherence tomography |
| CN113469936A (en) * | 2021-05-08 | 2021-10-01 | 温州医科大学 | Human eye cataract detection system and crystalline lens three-dimensional model image reconstruction method |
| CN113469936B (en) * | 2021-05-08 | 2023-10-03 | 温州医科大学 | Human eye cataract detection system and three-dimensional model image reconstruction method of crystalline lens |
| CN114373216A (en) * | 2021-12-07 | 2022-04-19 | 图湃(北京)医疗科技有限公司 | Eye movement tracking method, device, equipment and storage medium for anterior segment OCTA |
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