CN104545772B - A kind of combined type Narrow-Band Imaging endoscopic imaging system - Google Patents
A kind of combined type Narrow-Band Imaging endoscopic imaging system Download PDFInfo
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- CN104545772B CN104545772B CN201410804253.4A CN201410804253A CN104545772B CN 104545772 B CN104545772 B CN 104545772B CN 201410804253 A CN201410804253 A CN 201410804253A CN 104545772 B CN104545772 B CN 104545772B
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- A61B1/00—Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor
- A61B1/04—Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor combined with photographic or television appliances
- A61B1/05—Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor combined with photographic or television appliances characterised by the image sensor, e.g. camera, being in the distal end portion
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Abstract
nullThe invention discloses a kind of combined type Narrow-Band Imaging endoscopic imaging system，Include the Narrow-Band Imaging module for macroscopic view imaging，Narrow-Band Imaging module is by white light source，Narrow-band-filter dish，3rd collimating lens，Broadband light splitting flat board，Dichroic mirror，4th collimating lens，Colour image sensing device forms，It is additionally provided with the optical coherence tomography module for microcosmic imaging，Optical coherence tomography module and Narrow-Band Imaging module share identical light path system，The balanced detector controlling colour image sensing device and optical coherence tomography module that main frame controls Narrow-Band Imaging module respectively carries out the collection of data，By to the process gathering data，Export two groups of diagnostic images mutually confirmed，By combining optical coherence tomography and Narrow-Band Imaging，Combine the function of microcosmic imaging and macroscopic view imaging，Make and there is high sensitivity and specific medical diagnostic tool.
Description
Technical field
The present invention relates to the field of medical imaging detection technique, be specifically related to a kind of endoscope utilizing Narrow-Band Imaging art and become
As system.
Background technology
Narrow-Band Imaging art (Narrow Band Imaging, NBI), is a kind of emerging endoscopic technic, in conditional electronic
Mirror mirror uses the wideband white light source such as xenon lamp or halogen tungsten lamp as illumination light, and optical filter allows the visible ray of all wavelengths to lead to
Cross, and Narrow-Band Imaging endoscope adds narrowband light filter after white light source, wideband white is filtered, only stay
Centre wavelength is limited the narrow-band spectrum of 605nm, 540nm and 415nm, and is transmitted to wait to see by this narrow-band spectrum
Examine target surface.It is different that arrowband light wave penetrates the degree of depth of mucosa, and blue wave band (415nm) penetrates shallower, red
Wave band (605nm) can be used for showing vasoganglion under mucosa as deep as Submucosa, and green band (540nm) then can be relatively
Show well the blood vessel in intermediate layer.Owing to blue, green glow are absorbed relatively strong by the optical characteristics of blood in mucosa, therefore use difficulty
With diffusion the light wave that can be absorbed by the blood, by increasing capacitance it is possible to increase the contrast of blood vessel and definition under mucosal epithelium and mucosa, lead to
Cross and shooting image is decomposed according to different spectrum and analyzes, the image of the different mucosa degree of depth can be obtained, it is thus achieved that preferably
Observing effect.Therefore, Narrow-Band Imaging endoscope has in the effect being equivalent to mucosa dyeing, also referred to as electron staining
Mirror.Due to the above feature so that the endoscope combining narrow band imaging may be used for examining of mucosa microangiopathies
Disconnected, such as cancer, early cervical carcinoma, colon early cancer etc. in middle hypopharynx early cancer, epithelium of esophagus, these diseases typically can
Lesion increased vascularization, mucous membrane surface structure is caused to change.Narrow-Band Imaging endoscope can observe these pathological changes in time
Structure, the early diagnosis and therapy for these diseases provides help.
But, data shows, Narrow-Band Imaging adds magnifying endoscope can clearly illustrate that the recessed ratio of epithelial gland is respectively 61%.
Specificity to colonic hyperplasia polyp, adenoma and early cancer is about 80%.Reason is that Narrow-Band Imaging can only be seen
Examine the change of mucosa microvascular color, be finally shown that two dimensional image, simultaneously conventional endoscope imaging system image resolution
Rate is only at tens microns, it is impossible to early stage, the pathological changes of mucomembranous epithelial cell level is accurately positioned, also cannot be to pathological changes
Region carries out detailed analysis.And the spatial resolution of microcosmic imaging is about several microns, it is possible to achieve histiocyte degree
Accurately measure.Therefore, this imaging technique existing there is also, for early lesion diagnosis, the place can improved and develop.
Summary of the invention
In place of it is an object of the invention to overcome above-mentioned the deficiencies in the prior art, on the basis of existing Narrow-Band Imaging scope,
Devise a kind of combined type Narrow-Band Imaging endoscopic imaging system, by combining optical coherence tomography and Narrow-Band Imaging,
The macroscopic view that can realize medical sample is mutually confirmed to microcosmic imaging, imaging results, makes and has high sensitivity with special
The medical diagnostic tool of property.
The purpose of the present invention one is achieved by the following technical solution:
A kind of combined type Narrow-Band Imaging endoscopic imaging system, includes the Narrow-Band Imaging module for macroscopic view imaging, arrowband
Image-forming module by white light source (16), narrow-band-filter dish (17), the 3rd collimating lens (18), broadband light splitting flat board (19),
Dichroic mirror (20), the 4th collimating lens (21), colour image sensing device (22) forms, it is characterised in that: also
Being provided with the optical coherence tomography module for microcosmic imaging, optical coherence tomography module is with Narrow-Band Imaging module altogether
With identical light path system, control main frame (24) and control colour image sensing device 22 He of Narrow-Band Imaging module respectively
The balanced detector (23) of optical coherence tomography module carries out the collection of data, by the process to collection data,
Export two groups of diagnostic images mutually confirmed (25).
Optical coherence tomography (Optical coherence tomography, OCT) is to utilize weak coherent light to interfere
Ultimate principle, biological tissue's different depth aspect can be detected and to the back-reflection of incident weak coherent light or scatter letter several times
Number, by scanning, available biological tissue three dimensional structure image, can realize biological tissue microstructural contactless,
Noninvasive fault imaging.Utilize principle of interference, by low coherence interference of light, compare reflecting light and with reference to light wave
Measure time delay and the reflex strength launching light wave.Due to interfere only occur in signal arm identical with reference arm length time,
So changing the position of illuminator, just changing the length of reference arm, can thus obtain the signal of the tissue of different depth.
These optical signals just can obtain tissue faultage image through computer disposal.Optical coherence tomography is ultrasonic optical mode
Plan product, but its axial resolution depends on the coherence of light source, typically up to 10um, and can reach in biological tissues
The penetration depth of about 3mm, enough detects lesion region.Its lateral resolution depends on the numerical aperture of microcobjective,
Under the microcobjective of high-NA, lateral resolution is up to 0.5um.Therefore OCT can observe mucous membrane surface very well
Tissue three-dimensional structure, it is provided that mucomembranous epithelial cell is realized the high-resolution imaging of nm level and the Depth Imaging letter of mm level
Breath, is accurately positioned and analyzes the region of mucous epithelium minority pathological changes.
Further, described optical coherence tomography module comprises guiding light source (1), single-mode fiber (2), wavelength-division
Multiplexer (3), swept light source (4), optical circulator (5), direction is 5-a, and 5-b, 5-c are clockwise, and two light sources lead to
Crossing the fiber coupler (6) of 5:5, energy is delivered to reference arm and sample arm respectively, and wherein reference arm is by optical delay
Line (7), the first collimating lens (8), infrared total reflective mirror (9) forms, and sample arm is through Polarization Controller (10) even
To endoscope system (11).
Described endoscope system (11) contains optical coherence tomography and two kinds of imaging modes of Narrow-Band Imaging, optics
Coherence tomography is made up of the second collimating lens (12), scanning galvanometer (13), double glued achromats (14),
And light beam converges at sample (15) place, return signal is respectively by colour image sensing device (22) and balanced detector
(23) receive.
Control main frame (24) first passes through Narrow-Band Imaging and sample (15) carries out two-dimensional imaging, controls narrow-band-filter dish (17),
Colour image sensing device (22) operates, and collects the image of Narrow-Band Imaging, observes and exists abnormal or cannot judge
Area, be then shut off Narrow-Band Imaging module, use and guide light source (1) to be accurately positioned, open optics phase
Dry fault imaging module carries out imaging, controls optical delay line (7), Polarization Controller (10), scanning galvanometer (13),
Balanced detector (23) operates, and collects the image of OCT image, processes eventually through relevant data, output
Two groups of diagnostic images mutually confirmed (25).
Described optical coherence tomography system can be to meet the interferometer of traditional optical coherence tomography, can
To be Time Domain Optical coherence tomography device, it can be spectroscopic optics coherence tomography device.
The present invention, compared with conventional art, has the advantage that 1, combines optical coherence tomography and Narrow-Band Imaging two
Individual integrated imaging system, is integrated with high-precision three-dimensional scanning imagery and the height of Narrow-Band Imaging of optical coherence tomography
The two-dimensional imaging of definition, can realize the imaging by macroscopic view to micro-scale of the medical tissue sample, and imaging results can mutually print
Card, can improve sensitivity and specific medical diagnosis result for medical imaging, facilitate medical worker to carry out Accurate Diagnosis.
2, during the probe of image-forming module all concentrates on an endoscope system, two kinds of imaging modes use identical light path system, knot
Structure is compact, and uses different-waveband to carry out imaging, and image quality does not the most exist interference.
Accompanying drawing explanation
Fig. 1 is the system connection diagram of the present invention.
Fig. 2 is that the system of the present invention controls schematic diagram.
Detailed description of the invention
For making the purpose of the present invention, technical scheme and advantage clearer, clear and definite, develop simultaneously embodiment pair referring to the drawings
The present invention further describes.
As it is shown in figure 1, be the combined type Narrow-Band Imaging endoscopic imaging system schematic diagram of the present embodiment.Specifically can be divided into
Optical coherence tomography module and Narrow-Band Imaging module, wherein optical coherence tomography module comprises guiding light source 1,
Single-mode fiber 2, wavelength division multiplexer 3, swept light source 4, optical circulator 5, its direction is 5-a, and 5-b, 5-c are clockwise,
Two light sources pass through the fiber coupler 6 of 5:5, and energy is delivered to reference arm and sample arm respectively, and wherein reference arm is by light
Learning delay line 7, the first collimating lens 8, infrared total reflective mirror 9 forms, and sample arm is connected to scope through Polarization Controller 10
In system 11.Endoscope system 11 contains optical coherence tomography and two kinds of imaging modes of Narrow-Band Imaging, optics
The opticator of coherence tomography is made up of the second collimating lens 12, scanning galvanometer 13, double glued achromats 14,
And light beam converges at sample 15.Narrow-Band Imaging module is by white light source 16, narrow-band-filter dish 17, and the 3rd collimation is thoroughly
Mirror 18, broadband light splitting flat board 19, dichroic mirror 20, the 4th collimating lens 21, colour image sensing device 22 forms.
Return signal is received by colour image sensing device 22 and balanced detector 23 respectively.
As in figure 2 it is shown, control main frame 24 can control colour image sensing device 22 respectively and balanced detector 23 enters
The collection of row data, first uses Narrow-Band Imaging module that tissue sample carries out two-dimensional imaging, controls narrow-band-filter dish 17, color
Color image receives device 22 and operates, and collects the image of Narrow-Band Imaging, observes and there is portion that is abnormal or that cannot judge
Region, position, is then shut off Narrow-Band Imaging module, uses and guides light source 1 to be accurately positioned, and opens optical coherence tomography and becomes
As module carries out imaging, controlling optical delay line 7, Polarization Controller 10, scanning galvanometer 13, balanced detector 23 enters
Row running, collects the image of OCT image, processes eventually through relevant data, exports two imaging systems and mutually confirm
Diagnostic image 25.
Its specific works principle is: guides light source 1 to send beam of laser, couples through single-mode fiber 2, wavelength division multiplexer
The conduction of 3, arrives the fiber coupler 6 that splitting ratio is 5:5, its role is to guided laser light source to observation position
Be accurately positioned, facilitate optical coherence tomography module to determined by region be scanned imaging.Optical coherence tomography becomes
In Xiang, another light source is swept light source 4, and centre wavelength is 1310nm, bandwidth 100nm, and long-wave band can be to tissue mucosa sample
Product carry out the accurate scan of the bigger degree of depth, and this light beam of light source, through optical fiber circulator, is transmitted to the light that splitting ratio is 5:5
Fine bonder 6, and be divided into reference light and sample light two-way, reference light leads up to the optical delay line 7 light to reference light
Journey is adjusted, and is allowed to mate with the light path on sample light one tunnel, anti-through the first collimating lens 8 and infrared total reflective mirror 9
Light, light beam returns in the middle of fiber coupler.Another road sample light is through the adjustment of Polarization Controller so that light polarization
Optimized, to improve the contrast of stripe pattern.It is scanned through galvanometer 13, dichroic mirror 20, broadband light splitting flat board
19, and double glued achromat 14, arrive sample surfaces, sample can carry out degree of depth 3-D scanning imaging.Wherein
Dichroic mirror is more than 800nm transmission, and below 800nm reflects, the use of double glued achromats 14 be so that
The image quality of two image-forming modules is mated.The sample light finally carrying sample message returns in fiber coupler, with
The reference light of aplanatism difference interferes, and returns in wavelength division multiplexer and optical fiber circulator, finally by balanced detector
Detecting interference signal, due to the existence of relevant door, this signal has the highest longitudinal resolution, sample can be carried out um
The degree of depth 3-D scanning of magnitude.
Narrow-Band Imaging module is integrated in endoscopic system 11 with identical light path, white light source 16, through fiber optic conduction,
Carrying out light splitting by narrow-band-filter dish 17, obtaining required centre wavelength is the limited of 605nm, 540nm and 415nm
Individual narrow-band spectrum is passed through, the 3rd collimating lens 18 and broadband light splitting flat board 19, through double glued achromats 14 assemble with
Sample surfaces carries out imaging, and light beam passes through broadband light splitting flat board 19 afterwards, and dichroic mirror 20, lens 21 collect and optical fiber
Inside, and this narrow-band spectrum is radiated at coloured image reception device 22, due to Narrow-Band Imaging, signal can be to sample
Product carry out the two dimensional image of high-contrast and definition.
As being embodied as row, white light source used herein is xenon lamp.Tissue mucosa is cervix uteri epidermis, but not office
It is limited to cervical tissue.The tissue sample that patent of the present invention is mentioned, is not limited to skin, the cervical mucosal mentioned in literary composition, also
It is applicable to the tissues such as lymph, esophagus, cardiovascular.
It should be appreciated that the application of this patent is not limited to above-mentioned citing, for those of ordinary skills, can
To be improved according to the above description or to convert, all these modifications and variations all should belong to this patent claims
Protection domain.
Claims (4)
1. a combined type Narrow-Band Imaging endoscopic imaging system, include for macroscopic view imaging narrow
Band image-forming module, Narrow-Band Imaging module is by white light source (16), narrow-band-filter dish (17), the 3rd collimation
Lens (18), broadband light splitting flat board (19), dichroic mirror (20), the 4th collimating lens (21), cromogram
As sensing device (22) composition, it is characterised in that: it is additionally provided with the optical coherence for microcosmic imaging and breaks
Layer image-forming module, wherein comprises and guides light source (1), single-mode fiber (2), wavelength division multiplexer (3),
Swept light source (4), optical circulator (5), two light sources are by fiber coupler (6), and energy divides
Supplementary biography is delivered to reference arm and sample arm, and wherein reference arm is by optical delay line (7), and the first collimation is thoroughly
Mirror (8), infrared total reflective mirror (9) forms, and sample arm is in Polarization Controller (10) is connected to
In mirror system (11), described endoscope system contains optical coherence tomography and arrowband becomes
As two kinds of imaging modes, the opticator of optical coherence tomography by the second collimating lens (12),
Scanning galvanometer (13), double glued achromat (14) compositions, and light beam converge at sample
(15) place, return signal is respectively by colour image sensing device (22) and balanced detector (23)
Receive；
Optical coherence tomography module and Narrow-Band Imaging module share identical light path system, control
Main frame (24) controls the colour image sensing device (22) of Narrow-Band Imaging module respectively and optical coherence breaks
The balanced detector (23) of layer image-forming module carries out the collection of data, by the process to collection data,
Export two groups of diagnostic images mutually confirmed (25).
Imaging system the most according to claim 1, it is characterised in that control main frame (24) first
By Narrow-Band Imaging module, sample (15) is carried out two-dimensional imaging, control narrow-band-filter dish (17), color
Color image sensing device (22) operates, and observes and there is area that is abnormal or that cannot judge,
It is then shut off Narrow-Band Imaging module, uses and guide light source (1) to be accurately positioned, open optics phase
Dry fault imaging module carries out imaging, controls optical delay line (7), Polarization Controller (10), scanning
Galvanometer (13), balanced detector (23) operates, and processes eventually through corresponding data, output
Two groups of diagnostic images mutually confirmed (25).
Imaging system the most according to claim 1 and 2, it is characterised in that described optics
Coherence tomography module is to meet traditional optical coherence tomography interferometer.
Imaging system the most according to claim 3, it is characterised in that described in meet tradition light
Learn coherence tomography interferometer, can be Domain optical coherence tomographic imaging apparatus, can
To be spectrum-type optical coherence tomographic imaging apparatus.
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| Publication number | Priority date | Publication date | Assignee | Title |
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| US11890213B2 (en) | 2019-11-19 | 2024-02-06 | Zenflow, Inc. | Systems, devices, and methods for the accurate deployment and imaging of an implant in the prostatic urethra |
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| CN105796044B (en) * | 2016-05-25 | 2017-08-25 | 珠海康弘发展有限公司 | Endoscope and its imaging method |
| AU2017371223B2 (en) | 2016-12-09 | 2023-04-27 | Zenflow, Inc. | Systems, devices, and methods for the accurate deployment of an implant in the prostatic urethra |
| CN108245121A (en) * | 2016-12-29 | 2018-07-06 | 刘小华 | Endoscope and its imaging method and intelligent diagnosis system |
| CN107328743B (en) * | 2017-07-05 | 2023-03-28 | 广东欧谱曼迪科技有限公司 | Optical coherent confocal microscopy endoscope system and implementation method |
| CN110119033B (en) * | 2018-02-05 | 2020-08-11 | 清华大学 | Infrared imaging system |
| CN108514404B (en) * | 2018-03-28 | 2021-08-10 | 深圳市太赫兹科技创新研究院 | Optical coherence tomography system |
| CN108926318A (en) * | 2018-07-16 | 2018-12-04 | 广州狄卡视觉科技有限公司 | Operation display system and method based on 3D endoscope miniature image |
| CN109998456A (en) * | 2019-04-12 | 2019-07-12 | 安翰科技(武汉)股份有限公司 | Capsule type endoscope and its control method |
| CN110248063B (en) * | 2019-06-24 | 2023-12-26 | 华中科技大学 | Color coherent imaging device and method for lens-free microscopic system |
| CN111568359A (en) * | 2020-05-15 | 2020-08-25 | 北京大学第三医院（北京大学第三临床医学院） | Laryngoscope device |
| CN112450873A (en) * | 2020-11-20 | 2021-03-09 | 爱博图湃(北京)医疗科技有限公司 | Optical coherence tomography system for testing and matching orthokeratology mirror |
| CN114176483B (en) * | 2021-12-16 | 2023-08-29 | 重庆西山科技股份有限公司 | Polarized light endoscope device camera optical system, camera and endoscope device |
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| CN201085617Y (en) * | 2007-10-25 | 2008-07-16 | 浙江大学 | Single fiber endoscopic system integrating optical coherence tomography and laser-induced fluorescence optical spectrum |
| US20100094138A1 (en) * | 2008-07-25 | 2010-04-15 | Morteza Gharib | Imaging catheter using laser profile for plaque depth measurement |
| JP5550574B2 (en) * | 2011-01-27 | 2014-07-16 | 富士フイルム株式会社 | Electronic endoscope system |
| WO2012140970A1 (en) * | 2011-04-11 | 2012-10-18 | オリンパスメディカルシステムズ株式会社 | Endoscope device |
| CN102824154B (en) * | 2012-09-04 | 2015-03-04 | 无锡微奥科技有限公司 | Combined endoscope imaging system based on OCT (Optical Coherence Tomography) and imaging method |
| CN102920420B (en) * | 2012-10-11 | 2015-07-29 | 北京大学 | A kind of endoscope apparatus |
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| US11890213B2 (en) | 2019-11-19 | 2024-02-06 | Zenflow, Inc. | Systems, devices, and methods for the accurate deployment and imaging of an implant in the prostatic urethra |
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