CN108968922A - A kind of hand-held compact oedema detection device and its data processing method based on near-infrared absorption - Google Patents
A kind of hand-held compact oedema detection device and its data processing method based on near-infrared absorption Download PDFInfo
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/48—Other medical applications
- A61B5/4869—Determining body composition
- A61B5/4875—Hydration status, fluid retention of the body
- A61B5/4878—Evaluating oedema
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/0059—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence
Abstract
The invention discloses a kind of hand-held compact oedema detection device and its data processing method based on near-infrared absorption, comprising: for generating the near-infrared light source of specific band infrared light ultra-wide spectrum；Infrared light is divided into two bundles output and receives the two-way infrared light of return, forms the beam splitter of interference light after the two is merged；The reference arm of reference light is provided；It is incident upon in tested tissue after another way infrared light is focused, and receives the sample arm from the reflected infrared light of tested tissue；It receives the near infrared light after merging and is irradiated to light beam in CCD camera after transmission grating is by wavelength dispersion.The present invention estimates the ponding relative amount of tested tissue using the back-scattering light detected.
Description
Technical field
The present invention relates to oedema detection fields, and in particular to a kind of hand-held compact oedema based on near-infrared absorption
Detection device and its data processing method.
Background technique
With the improvement of living standards, along with the expensive of environmental degradation, people are to health problem growing interest.In real time
Non-invasive monitoring technology has the effects of screening monitoring, early detection, auxiliary diagnosis.Therefore highly sensitive, safe and harmless is all
The core of monitoring technology.For the oedema situation diagnosis of heart failure, renal failure patient, the estimation of dialysis interval duration relies on for a long time
The palpation of doctor and blood count lack real-time, quick, noninvasive detection methods.Develop the Gao Ling of a suitable practical clinical
Sensitivity, easy-operating oedema detection device seem pole it is necessary to.
Optical coherence technology has the sensitivity and resolution ratio of superelevation, and fast imaging ability makes it be widely used in recent years
In underlying biological and biomedical research.Traditional optical coherence technology using 1310 nano wavebands to the low absorption of tissue and
Reflective tomographic imaging ability is obtained compared with strong scattering；High-resolution is obtained using the high scattering low absorption of 800 nano wavebands
The tomograph of high contrast, but the penetration capacity of imaging beam is hence limited, reduce its intrinsic chromatography advantage.It is close red
Outer light enhances the penetration capacity of biological tissue with the increase of wavelength.1470 nano wave lengths are a water of near infrared band
Peak is absorbed, the wave band is commonly used clinically to carry out some heat and melts treatment.According to Lambert Beer law, contain light absorption object
Uptake and substance content exponent function relation in the solution of the solution of matter to light.Therefore when 1470 nm near-infrared illumination
When penetrating in water content tissue abundant, light is largely absorbed by water, and compared with water content is normally organized, either transmitted light is also
It is that reflected light is exponentially reduced.
Due to safety concerns, clinically there is stringent limitation to the light intensity of optical means and irradiation time.In conjunction with water pair
The high-absorbable of 1470 nano wave lengths and the high sensitivity of optical coherence technology irradiate edematous site with lesser light intensity, utilize
The back-scattering light detected estimates that ponding relative amount is a kind of method for being worth probing into.
Summary of the invention
Object of the present invention is to: a kind of hand-held compact oedema detection device and its number based on near-infrared absorption is provided
The purpose of estimation ponding relative amount is realized using the back-scattering light detected according to processing method.
The technical scheme is that a kind of hand-held compact oedema detection device based on near-infrared absorption, packet
It includes:
The near-infrared light source of ultra-wide spectrum, for generating specific band infrared light；
Beam splitter receives the emergent light of the near-infrared light source, the infrared light is divided into two bundles output, and receive return
Two-way infrared light, after merging generate interference light be output to spectrometer；
Reference arm is connected with the optical path all the way of the beam splitter, and the reference arm includes plano-convex cylindrical lens, dispersion compensating
Block and high reflectance plane mirror, the infrared light all the way focus on the plane mirror through plano-convex cylindrical lens, then anti-through plane mirror
It penetrates and returns to the beam splitter, the dispersion compensation module is used to match the dispersion differences of reference arm and sample arm；
Sample arm is connected with the another way optical path of the beam splitter, and the sample arm includes antireflective optical probe, described
Optic probe focuses on infrared light in tested tissue, and receives from the reflected infrared light of tested tissue, is transmitted back to beam splitting
Device；
Near infrared spectrum survey meter is connect with the merging optical output mouth of the beam splitter, and the spectrum detection instrument includes
Grating, scanning lens and CCD camera, the infrared light that the reference arm returns are dividing with from the reflected infrared light of tested tissue
Beam device forms interference signal, is detected by the near infrared spectrum survey meter, and specifically light beam is by transmission grating by wavelength point
It is irradiated in CCD camera after dissipating, generates image；
Driver, for controlling, the acquisition of synchronized signal, data, digitalized data, processing and store and display number
According to.
In one embodiment, the near-infrared light source includes the wide range near infrared laser being sequentially arranged, high-pass filtering
Device and free optical path fiber coupler, the wide range near infrared laser carry out light source as light source, the high-pass filter
After high-pass filtering processing, retain the infrared light of specific band, delivery outlet of the coupler as the infrared light generated.
In one embodiment, the near-infrared light source further includes Polarization Controller, and the Polarization Controller is set to height
Between bandpass filter and coupler, for controlling the polarization state of infrared light, guarantee that the light source power of output is maximum.
In one embodiment, the dispersion compensation module be prism to a, optical fiber, one with pop one's head in model
Any one of identical plano-convex cylindrical lens or achromatic lens.
In one embodiment, the probe of the sample arm is preceding to optical mode out using the two dimension of no built-in scan function,
The optic probe uses object lens of the plano-convex cylindrical lens as focal imaging light beam.
In one embodiment, the probe of the sample arm is lateral using the two dimension or three-dimensional for being built-in with MEMS scanning galvanometer
Optical mode out.
In one embodiment, the optic probe is using plano-convex cylindrical lens or achromatism condenser lens as focal imaging
The object lens of light beam, The plano-convex cylindrical lens or achromatism condenser lens have both outgoing detection light beam and collecting signal light beam.
In one embodiment, the specific band infrared light that the near-infrared light source generates is 1475 nanometers of center wavelength
And the continuous near infrared light of wide range that bandwidth halfwidth is 400 nanometers.
In one embodiment, the near infrared spectrum survey meter further includes one and is set between grating and scanning lens
Prism, the prism matches in pairs with grating, will receive wavelength linear detection light and is converted into wave number linear probing light, described
CCD camera is area array CCD camera.
The embodiment of the present invention also provides a kind of oedema detection device data processing method, comprising:
The signal of multiple continuous scanning points in image or a sub-picture to several same positions is averaged to remove
Noise jamming；
Different location and the corresponding backscattering light intensity signal value of depth i are obtained using the image detected；
Local Phase is calculated according to the following formula to water content:
Wherein, CiIt is the Local Phase at tissue depth i to water content, IiIt is the signal value at depth i, Δ d is different
The distance between depth, InIt is the following different location signal value of depth i.
The invention has the advantages that the oedema content detection device high sensitivity provided, miniaturization, operability are well.Dispersion
The introducing of compensating module matches the dispersion differences of reference arm and sample arm in interferometer, to improve longitudinal resolution.Polarization Control
The introducing of device maximises output power, improves signal-to-noise ratio.Grating-prism pair is closed by match group, wavelength linear will be received
Detection light is converted into wave number linear probing light, to reduce consumption of the software post-processing to computer system, to promote entire visit
The speed of survey process.Relative to the high radiation of X-ray or CT, the high cost of MRI technique, apparatus of the present invention utilize optical hand
Section, it is safe and harmless and economical and practical, it is easier to benefit patient.
Detailed description of the invention
The invention will be further described with reference to the accompanying drawings and embodiments:
Fig. 1 is that the two dimension in sample arm of embodiment of the present invention probe using no built-in scan function is preceding to optical mode out, light
It learns probe and uses structural schematic diagram of the plano-convex cylindrical lens as object lens；
Fig. 2 is laterally to go out optical mode using the three-dimensional for being built-in with MEMS scanning galvanometer in sample arm of embodiment of the present invention probe
Formula, optic probe use structural schematic diagram of the achromatism condenser lens as object lens；
Fig. 3 is the schematic diagram of hand-held compact oedema detection device of the embodiment of the present invention based on near-infrared absorption；
Fig. 4 is the embodiment of the present invention under different water contents, detects the logarithm of backscattering luminous intensity and tissue depth
Relational graph；
Fig. 5 is the embodiment of the present invention using the backscattering luminous intensity detected, and the water content contained by different depth is equal
In the case of the water content figure that estimates, wherein the C value in legend is theoretical water content, and the value by arrow mark is that algorithm estimates
Water content；
Fig. 6 is the embodiment of the present invention using the backscattering luminous intensity detected, and the water content contained by different depth differs
In the case where the depth that estimates, the relational graph of water content and backscattering light intensity.
Specific embodiment
The principle and features of the present invention will be described below with reference to the accompanying drawings, and the given examples are served only to explain the present invention, and
It is non-to be used to limit the scope of the invention.
The present invention is imaged using near infrared light and the relevant principle of spectral domain optical.It is briefly exactly to issue light source
Light is divided into two beams, a branch of to be emitted to testee, this optical path is referred to as sample arm, and another beam is formed through reflecting mirror with reference to letter
Number, which is known as reference arm., when sample arm and the optical path difference of reference arm are located in the interference length of light source, from tissue (sample
Product arm) and from reflecting mirror (reference arm) return two-beam can be superimposed to form interference signal.The reflected light letter from tissue
It is number different and strong and weak different with the property (scattering and absorb etc.) of tissue.These optical signals are by computer Fourier transformation
Reason can obtain tissue faultage image.A kind of hand-held compact oedema detection based on near-infrared absorption provided by the invention
Device, comprising: the near-infrared light source of ultra-wide spectrum, for generating specific band infrared light, it is preferred that the near-infrared light source includes
Wide range near infrared laser 01, high-pass filter 02 and free optical path fiber coupler 03, the wide range being sequentially arranged are closely red
After outer laser 01 is used as light source, the high-pass filter to carry out high-pass filtering processing to light source, retain the infrared of specific band
Light, exit portal of the coupler 03 as the infrared light generated.Preferably, the specific band that the near-infrared light source generates
The super continuous near infrared light of the wide range that infrared light is 1475 nanometers of center wavelength and bandwidth halfwidth is 400 nanometers；Beam splitter 04, connects
The infrared light is divided into two bundles output by the emergent light for receiving the near-infrared light source, and receives the two-way infrared light of return, is merged
After be output to spectrometer；Reference arm is connected with the optical path all the way of the beam splitter, and the reference arm includes plano-convex cylindrical lens 14,
Dispersion compensation module 06 and high reflectance plane mirror 07, the infrared light all the way focus on the plane mirror 07 through plano-convex cylindrical lens
On, then through the reflection return of plane mirror 07 beam splitter；Sample arm is connected with the another way optical path of the beam splitter, the sample
Product arm includes antireflective optical probe 12, and the optic probe focuses on infrared light in tested tissue, and is received from tested group
Reflected infrared light is knitted, beam splitter is transmitted back to；Near infrared spectrum survey meter detects the interference letter formed at beam splitter
Number, and tomograph is generated after being transmitted to Computer reprocessing, the spectrum detection instrument includes grating, scanning lens and CCD
Camera, the infrared light that the reference arm returns form interference signal with from the reflected infrared light of tested tissue in beam splitter,
It is detected by the near infrared spectrum survey meter, specifically light beam is irradiated to CCD camera after transmission grating is by wavelength dispersion
On, generate image.The device further includes driver, for controlling and synchronized signal and data acquisition, digitalized data, place
Manage data acquisition, display and the memory module of simultaneously storing data.It further include that driving MEMS is swept if built-in MEMS scanning galvanometer
Retouch galvanometer.Apparatus of the present invention as shown in figure 3, the small-signal from sample arm after the amplification of reference arm signal, can be by
Spectrometer detection arrives.Wherein, ultra-continuous wideband light source 01 is passing through high-pass filtering piece 02 (Thorlabs, FEL1200) to the light
After source carries out high-pass filtering processing, retain the light of 1200 nanometers of above wavelength, as the input of beam splitter 04, light beam passes through beam splitting
After device 04, with the light splitting rate of 50:50 by central wavelength for 1475 nanometers, bandwidth halfwidth is that 400 nanometers of near infrared light is defeated
Give the reference arm and sample arm of interferometer.It is micro- that 400 nanometers of bandwidth makes the longitudinal resolution of apparatus of the present invention reach 2.4
Rice.In conjunction with the lateral resolution of above-mentioned 2-12 micron, the present invention is in the longitudinal direction for having outside high sensitivity while being also equipped with superelevation
Lateral resolution, using the above method, the present apparatus has up to -100dB sensitivity.
Preferable in the embodiment of the present invention, the near-infrared light source further includes Polarization Controller 05, the Polarization Controller
It is set between high-pass filter and coupler, for controlling the polarization state of infrared light, light source output power is maximum, to guarantee
High s/n ratio.
The embodiment of the present invention is preferred, and the reference arm further includes dispersion compensation module 06, for matching reference arm and sample
The dispersion differences of product arm, the dispersion compensation module be prism to, an optical fiber, a plano-convex identical with the interior model of probe
Any one of cylindrical mirror or achromatic lens, dispersion compensation can make the actual longitudinal resolution of system level off to theoretical value.
Preferred in one embodiment of the invention, the sample arm is preceding to optical mode out using the two dimension of no built-in scan function
Formula, object lens of the optic probe 12 using plano-convex cylindrical lens as focal imaging light beam.As shown in Figure 1.From fiber optic collimator mirror
The beam diameter of outgoing is 3.6 millimeters, is focused at 1.4 millimeters of cylindrical mirror by a plano-convex cylindrical lens 14, and gained is poly-
The lateral resolution of burnt hot spot is 2 microns.The windowpane 15 that one 11 mm of thickness of diameter is 1 millimeter protects plano-convex cylindrical lens not
It is polluted by sample.All above-mentioned components are all integrated in the stainless steel tube 13 of one section of thin-walled thickness.The probe uses plano-convex column
Object lens of the face mirror as focal imaging light beam, the collimated light beam with circular light spot gather on the direction that cylindrical mirror has curvature
Coke, and 3.6 millimeters of width is still kept on direction normal thereto, therefore, beating on sample is one 2 microns wide, long 3.6
The long and narrow light belt of millimeter, so that the probe naturally has two-dimensional detection ability, it must be by scanning without such as common Mapping
Galvanometer is just able to achieve two-dimensional imaging.
Preferred in one embodiment of the invention, the sample arm is using the two dimension or three-dimensional for being built-in with MEMS scanning galvanometer
Laterally go out optical mode.The galvanometer can freely realize one-dimensional or two-dimentional arbitrary patterns scanning, in conjunction with the intrinsic chromatography of the device
Ability provides two dimension or three-dimensional tissue's faultage image and two dimension or three-dimensional water content distribution map.Wherein, the optic probe 12
The object lens of plano-convex cylindrical lens or achromatism condenser lens as focal imaging light beam, the plano-convex cylindrical lens or colour killing can be used
Poor condenser lens has both outgoing detection light beam and collecting signal light beam.As shown in Fig. 2, passing through from 17 outgoing beam of achromatic lens
MEMS galvanometer 18 reflects, and focuses on the outer 0.5 millimeter of distant place of glass protection window 16, and the lateral resolution that gained focuses circular light spot is
12 millimeters, all above-mentioned components are all integrated in the stainless steel tube 13 of one section of thin-walled thickness.Two-dimentional organization chart and two-dimentional water
Content distribution figure can scan to obtain by MEMS galvanometer single shaft；Engineering three-dimensional tissue structures figure and three-dimensional water content distribution map can pass through
MEMS galvanometer twin shaft scans to obtain；Scanning range is controlled by the driving voltage for supplying MEMS galvanometer.
The embodiment of the present invention is preferred, and the near infrared spectrum survey meter further includes one and is set to grating and scanning lens
Between prism, the prism matches in pairs with grating, wavelength linear detection light will be received and be converted into wave number linear probing light,
To save the numerical value resampling time, reach raising detection rates, the CCD camera is area array CCD camera.Common spectrometer
Generally it is made of grating 08, scanning lens 10 and CCD camera 11.Light beam is irradiated to after transmission grating 08 is by wavelength dispersion
It is along pixel orientation wavelength linear on CCD.And the signal that apparatus of the present invention utilize Fourier transformation to arrive spectrometer detection
It is reconstructed into the image with organizational information.Due to the ultrahigh resolution of the present apparatus, when visual field is 5 millimeters × 5 millimeters,
According to nyquist sampling law, 2222 × 4000 pixels ability complete characterizations are at least shared, it is meant that 4000 4096 (palpuses
It will be called in the reconstruction of an image to the Fourier transformation of 2222 zero paddings to 4096) a point.And original interference is believed
It number carries out Fourier and rebuilds to necessarily require original signal being linear about wave number (frequency domain).Therefore before Fourier transformation,
Each image must carry out 4000 difference operations in advance, and it is linear that signal from wavelength linear is switched to wave number.This process occupy compared with
More computer resources is to tie down real-time display.Spectrometer in apparatus of the present invention introduces a prism 09, utilizes grating
Negative dispersion and the positive dispersion of prism obtain the light beam for having wave number linear, so that the numerical value for eliminating much time resource is inserted
Value.Simultaneously as parallel detection is utilized in the present apparatus, reduce the scanning of a dimension, therefore use area array CCD camera.
A kind of oedema detection device data processing method is additionally provided in the embodiment of the present invention, comprising:
The signal of multiple continuous scanning points in image or a sub-picture to several same positions is averaged to subtract
Noise jamming；
Different location and the corresponding backscattering light intensity signal value of depth i are obtained using the image detected；
Local Phase is calculated according to the following formula to water content:
Wherein, CiIt is the Local Phase at tissue depth i to water content, IiIt is the signal value at depth i, Δ d is different
The distance between depth, InIt is the following different location signal value of depth i.
Specifically, the water content measurement method with chromatography ability proposed according to the present invention, first to several same positions
The signal of multiple continuous scanning points in the image or a sub-picture set is averaged to remove noise jamming.We according to
The formula that Lambert Beer law is derived:
Wherein, I0It is original incident light intensity, μsFor scattering coefficient, μaFor absorption coefficient, C is water content.Due in specific group
In knitting, such as skin, muscle, fat, the μ of connective tissue etc.sAnd μaIt is all more constant, therefore when measuring privileged site oedema, it can
By sum of the two, it is referred to as attenuation coefficient and is considered as constant value.Again due to the judgement of oedema degree be compared to for normal tissue, we
The C of normal tissue is set as 1, while by (μs+μa) C is defined as opposite water content, value can be quasi- by nonlinear least square
The interference signal after Fourier transformation is closed to obtain.
Investigate different water contents, i.e., different oedema degree and the signal strength relationship detected.As shown in Fig. 4, water content
Difference causes signal strength to be very different, and with the increase of depth, and thus caused signal intensity difference becomes more
Obviously.Be 5 for water content, signal in depth is that 1 millimeter of place has decayed 40dB, just because of the invention device be up to-
The sensitivity of 100dB, signal decaying so but can be still detected.
Fig. 5 illustrates the water content value by detectable signal, obtained according to formula (1) by nonlinear least square fitting.It is right
What is provided in upper angle marginal data is desired value, and corresponding 5 curves are the signals detected under different desired values.Left arrow refers to
What is shown is the water content value estimated by coherent signal.By comparing desired value and practical estimated value, it has been found that the two it
Between it is very close, error is only 5/1000ths.
The above analysis and calculating are all suitable only for the case where water content is evenly distributed within imaging depth, next divide
The case where analysis different depth water content is unevenly distributed.It is further deduced according to formula (2), available following relationship:
Wherein, CiIt is the Local Phase at tissue depth i to water content, IiIt is the signal value at depth i, Δ d is different
The distance between depth, InIt is the following different location signal value of depth i.According to this formula, different depth is obtained with can be convenient
The value of independent opposite water content.As shown in fig. 6, the opposite water content at 0-0.2 millimeters is the phase at 0.5,0.2-0.4 millimeters
It is opposite water content at 1,0.4-0.6 millimeters to water content is 0.3 etc..It can be found that the water content in the section 0.2-0.4 is most
It is high, it is meant that water is most strong to the absorption of light, therefore signal strength decline is most fast within the scope of this.Opposite, the section 0.4-0.6 Nei Shui
Content is minimum, it is meant that water is most weak to the absorbability of light, therefore signal strength decline is the slowest within the scope of this.
Hand-held compact oedema detection device disclosed by the invention based on near-infrared absorption takes full advantage of 1470
Nano waveband to the high-selenium corn of water and the high sensitivity of optical coherence technology, for clinical edema detection provide it is a kind of convenient and can
The method leaned on.According to water to the high-absorbable of 1470 nm near-infrared light, by detecting tissue backscatter signals, the detection side
Method can calculate edematous site automatically and be distributed in the water content of different tissues depth (compared to the non-edematous site water of homologue
Content).In addition, the device also serves as conventional near-infrared optical Laminographic device, for observing skin, eyes, mouth
The Histological Studies such as chamber provide important reference for the early diagnosis of related disease.And relative to X ray or CT
Height radiation, the high cost of MRI technique, apparatus of the present invention utilize optical means, safe and harmless and economical and practical, it is easier to benefit
Patient.The present invention can be also used for heart failure, renal failure etc. need the patient of chronic hemodialysis or the people at highest risk of such illness it is real-time,
Noninvasive monitoring instructs patient and doctor to make Corresponding Countermeasures in due course.
The present invention relates to a kind of with highly sensitive organism oedema content detection device.In addition to high sensitivity, if
Standby miniaturization and good operability are also the requirement of clinical application.The hand-held optical probe shape that apparatus of the present invention include
Extremely compact (12 millimeters of diameter × 22 millimeters of length), it is interior to contain scanning and focus and collect each of tissue back-scattering light
A optical element.
The above embodiments merely illustrate the technical concept and features of the present invention, and its object is to allow person skilled in the art
It cans understand the content of the present invention and implement it accordingly, it is not intended to limit the scope of the present invention.It is all to lead according to the present invention
The modification for wanting the Spirit Essence of technical solution to be done, should be covered by the protection scope of the present invention.
Claims (10)
1. a kind of hand-held compact oedema detection device based on near-infrared absorption characterized by comprising
The near-infrared light source of ultra-wide spectrum, for generating specific band infrared light；
Beam splitter receives the emergent light of the near-infrared light source, the infrared light is divided into two bundles output, and receive the two of return
Road infrared light generates interference light and is output to spectrometer after merging；
Reference arm is connected with the optical path all the way of the beam splitter, the reference arm include plano-convex cylindrical lens, dispersion compensation module and
High reflectance plane mirror, the infrared light all the way focus on the plane mirror through plano-convex cylindrical lens, then return through plane mirror reflection
The beam splitter is returned, the dispersion compensation module is used to match the dispersion differences of reference arm and sample arm；
Sample arm is connected with the another way optical path of the beam splitter, and the sample arm includes antireflective optical probe, the optics
Probe focuses on infrared light in tested tissue, and receives from the reflected infrared light of tested tissue, is transmitted back to beam splitter；
Near infrared spectrum survey meter is connect with the merging optical output mouth of the beam splitter, the spectrum detection instrument include grating,
Scanning lens and CCD camera, the infrared light that the reference arm returns with from the reflected infrared light of tested tissue in beam splitter
Interference signal is formed, is detected by the near infrared spectrum survey meter, specifically light beam is after transmission grating is by wavelength dispersion
It is irradiated in CCD camera, generates image；
Driver, for controlling, the acquisition of synchronized signal, data, digitalized data, processing and store and display data.
2. the hand-held compact oedema detection device based on near-infrared absorption as described in claim 1, which is characterized in that institute
Stating near-infrared light source includes the wide range near infrared laser being sequentially arranged, high-pass filter and free optical path fiber coupler, institute
Wide range near infrared laser is stated as light source, after the high-pass filter carries out high-pass filtering processing to light source, retains certain wave
The infrared light of section, delivery outlet of the coupler as the infrared light generated.
3. the hand-held compact oedema detection device based on near-infrared absorption as claimed in claim 2, which is characterized in that institute
Stating near-infrared light source further includes Polarization Controller, and the Polarization Controller is set between high-pass filter and coupler, is used for
The polarization state for controlling infrared light guarantees that the light source power of output is maximum.
4. the hand-held compact oedema detection device based on near-infrared absorption as described in claim 1, which is characterized in that institute
State dispersion compensation module be prism to, an optical fiber, a plano-convex cylindrical lens identical with the interior model of probe or achromatism
Any one of lens.
5. the hand-held compact oedema detection device based on near-infrared absorption as described in claim 1, which is characterized in that institute
The probe of sample arm is stated using, to optical mode out, the optic probe uses plano-convex cylindrical lens before the two dimension of no built-in scan function
Object lens as focal imaging light beam.
6. the hand-held compact oedema detection device based on near-infrared absorption as described in claim 1, which is characterized in that institute
The probe of sample arm is stated using the two dimension for being built-in with MEMS scanning galvanometer or three-dimensional lateral optical mode out.
7. the hand-held compact oedema detection device based on near-infrared absorption as claimed in claim 6, which is characterized in that institute
Optic probe is stated using the object lens of plano-convex cylindrical lens or achromatism condenser lens as focal imaging light beam, The piano convex cylindrical
Mirror or achromatism condenser lens have both outgoing detection light beam and collecting signal light beam.
8. the hand-held compact oedema detection device based on near-infrared absorption as described in claim 1, which is characterized in that institute
State the wide range that specific band infrared light is 1475 nanometers of center wavelength and bandwidth halfwidth is 400 nanometers of near-infrared light source generation
Continuous near infrared light.
9. the hand-held compact oedema detection device based on near-infrared absorption as described in claim 1, which is characterized in that institute
Stating near infrared spectrum survey meter further includes the prism being set between grating and scanning lens, and the prism is matched with grating
In pairs, wavelength linear detection light will be received and be converted into wave number linear probing light, the CCD camera is area array CCD camera.
10. a kind of oedema detection device data processing method characterized by comprising
The signal of multiple continuous scanning points in image or a sub-picture to several same positions is averaged to remove noise
Interference；
Different location and the corresponding backscattering light intensity signal value of depth i are obtained using the image detected；
Local Phase is calculated according to the following formula to water content:
Wherein, CiIt is the Local Phase at tissue depth i to water content, IiIt is the signal value at depth i, Δ d is different depth
The distance between, InIt is the following different location signal value of depth i.
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