CN104524519A - Special handkerchief paper suitable for patient suffering cold in the bud - Google Patents
Special handkerchief paper suitable for patient suffering cold in the bud Download PDFInfo
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- CN104524519A CN104524519A CN201410846919.2A CN201410846919A CN104524519A CN 104524519 A CN104524519 A CN 104524519A CN 201410846919 A CN201410846919 A CN 201410846919A CN 104524519 A CN104524519 A CN 104524519A
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Abstract
The invention relates to a special handkerchief paper suitable for a patient suffering cold in the bud. The special handkerchief paper is sprayed with an aroma essential oil composition, and the aroma essential oil composition has sweating, antipyretic and stuffy-nose-relieving functions. The aroma essential oil composition is prepared by, by weight, 1 cassia twig essential oil 5%, 2 fresh ginger essential oil 5%, 3 cocklebur fruit essential oil 3%, 4 radix angelicae essential oil 2%, 5 benzyl alcohol 5% and 8 absolute ethyl alcohol which form 100%. The special handkerchief paper has the fragrance effect on the patient in the using process and accordingly has obvious treatment effect of relieving symptoms of aversion to cold, fever, nasal obstruction, runny nose, sneeze and the like represented in the bud of the cold.
Description
Technical field
The present invention relates to the speciality paper handkerchief that a kind of common cold initial stage patient is suitable for.
Background technology
Flu is clinical upper respiratory system disease that is common, that caused by viral infection, especially easily sends out after drenching with rain or suffering from cold.Its primary clinical manifestation is: aversion to cold or heating, nasal obstruction, watery nasal discharge, sneeze, throat discomfort, giddy, limb aching pain, weak etc.Its pathology main manifestations is nasal cavity, mucous hyperemia, the swelling of throat, the catarrhal inflammation pathological characters such as to ooze out.Common cold initial stage, because of watery nasal discharge, sneeze, the more use of paper handkerchief becomes necessary naturally.Common paper handkerchief can only play wiping, clean effect, but there is no any effect to alleviation cold symptoms.In recent years, market there is " flu paper handkerchief " sell, it is after being dissolved by menthol ethanol, be sprayed on paper handkerchief and make, it has certain clear-headed, stimulating effect to cold patients, but to alleviating the symptom such as aversion to cold, heating, nasal obstruction, watery nasal discharge, sneeze that common cold initial stage shows without any effect.The invention provides the speciality paper handkerchief that a kind of common cold initial stage patient is suitable for, described speciality paper handkerchief is sprayed with a kind of volatile oil compositions, described volatile oil compositions has the function of diaphoresis, antipyretic, clearing the nasal passage, and it has obvious curative effect to alleviating the symptom such as aversion to cold, heating, nasal obstruction, watery nasal discharge, sneeze that common cold initial stage shows.
Summary of the invention
The invention provides the speciality paper handkerchief that a kind of common cold initial stage patient is suitable for, described speciality paper handkerchief is sprayed with a kind of volatile oil compositions, described volatile oil compositions has the function of diaphoresis, antipyretic, clearing the nasal passage.Described speciality paper handkerchief has obvious curative effect to the scent effect of patient to the symptom such as aversion to cold, heating, nasal obstruction, watery nasal discharge, sneeze that alleviation common cold initial stage shows in use procedure.
The formula of described volatile oil compositions is as follows: 1) Ramulus Cinnamomi quintessence oil, 5%; 2) ginger essential oil, 5%; 3) Fructus Xanthii quintessence oil, 3%; 4) Radix Angelicae Dahuricae quintessence oil, 2%; 5) benzyl alcohol, 5%; 6) dehydrated alcohol, adds to 100%.
If not particularly point out, percentage ratio of the present invention all refers to percentage by weight.
4 kind of plant quintessence oils in above-mentioned formula all can facilitate acquisition from the market, and 4 kind of plant of its correspondence are the medicinal herbs most in use of Chinese medicine treatment flu.
Benzyl alcohol in above-mentioned formula, mainly uses as fixastive, simultaneously by reducing vapour pressure to avoid the excessive volatilization of quintessence oil in the Synthesis and applications process of described volatile oil compositions.Experiment shows, if above-mentioned formula removes benzyl alcohol, the static saturated vapor pressure at its 25 DEG C is by rising about 15%.
Dehydrated alcohol in above-mentioned formula is dilution solvent.
The preparation method of described volatile oil compositions: under normal temperature condition, by the Material Percentage of described volatile oil composite formula, is placed in the stirred vessel of this area routine use, stirring, mix homogeneously, fill, sealing by all raw materials.
The described volatile oil compositions prepared as stated above is a kind of colourless transparent liquid, has strong characteristic aromatic odor, and its static saturated vapor pressure at 25 DEG C is 6.8 ± 0.3kPa.
The preparation method of described speciality paper handkerchief: tissue post-treatment process known in the art cut front operation section, adopt spraying apparatus well known in the art and discharge rate adjusting process, described volatile oil compositions is sprayed on any position (being preferably the relative middle part of paper handkerchief tissue used) of paper handkerchief tissue used, then cut, overlapping (2 layers or 3 layers), envelope pressure (or comprising cotton ginning), folding, pack.The spray dosage of described volatile oil compositions is 0.01 ~ 0.02% of paper handkerchief tissue weight used.
The Four Plants quintessence oil comprised in described volatile oil compositions is that from Chinese medicine treatment flu, conventional having tens of kinds of medical materials of relieving the exterior syndrome with drugs of pungent in flavor and warm in nature, diaphoresis, sensible function screens the present inventor; Screening take time several months, have passed many times test be just accomplished; The principal dimensions of screening is: the acceptability etc. of curative effect, safety, odor type.
The major function of described volatile oil compositions comprises following two aspects:
One, diaphoresis, antipyretic: the effect of its mainly Ramulus Cinnamomi quintessence oil, ginger essential oil.
Open research data shows, the main active of Ramulus Cinnamomi quintessence oil is cinnamic aldehyde, cinnamic acid and a small amount of acetic acid Cortex cinnamomi japonici (Ramulus Cinnamomi) ester, acetic acid benzene lactone, it has obvious diaphoresis, refrigeration function to laboratory animal, the mechanism of action is similar to aspirin, namely acts on the thalamus thermolytic centre of animal and causes diaphoresis.
Open research data shows, the main active of ginger essential oil is gingerol and shogaol, it also has certain diaphoresis, refrigeration function to laboratory animal, but site of action is SNE, its can bring out laboratory animal peripheral vasodilation, promote skin surface blood circulation and assist diaphoresis.
Two, antiinflammatory, stuffy nose relieving: the effect of its mainly Fructus Xanthii quintessence oil, Radix Angelicae Dahuricae quintessence oil.
Open research data shows, the main active of Fructus Xanthii quintessence oil is diterpene hydroxy acid xanthostrumarin, and it obviously can suppress rat skin inflammation swelling caused by Pelvetia siliquosa Tseng et C. F. Chang.
Open research data shows, the main active of Radix Angelicae Dahuricae quintessence oil is 3-methylene-6(1-first and second base)-ring alkene in the sixth of the twelve Earthly Branches, bergaptol and multiple coumarin kind compound, it obviously can suppress the inflammatory seep (capillary permeability enhancing) of dimethylbenzene induced mice ear; It, to White Rabbit High fever model caused by peptone hypodermic injection, has obvious refrigeration function.
The present inventor is screening, is determining, in the process of described volatile oil composite formula, successively to have carried out a large amount of pharmacological experiment studies.Experimental administration method is 400mmHg constant voltage aerosol, and the aerosol time is 30 seconds.Experimental result is as follows:
1, perspiration colouring diaphoresis experiment: the Ramulus Cinnamomi quintessence oil in described volatile oil compositions, ginger essential oil all have perspiration; Wherein, antiperspirant point time of occurrence, Ramulus Cinnamomi quintessence oil is obviously faster than ginger essential oil; In 5 minutes, antiperspirant is counted, and Ramulus Cinnamomi quintessence oil is obviously more than ginger essential oil; After the composite ginger essential oil of Ramulus Cinnamomi quintessence oil, antiperspirant point time of occurrence obviously shifts to an earlier date, in 5 minutes, antiperspirant is counted also showed increased, show that the diaphoresis effect of ginger essential oil to Ramulus Cinnamomi quintessence oil has obvious chemiluminescence, this may be different relevant from both diaphoresis mechanism: Ramulus Cinnamomi quintessence oil mainly acts on thalamus thermolytic centre and causes diaphoresis, the site of action of ginger essential oil is SNE, and it can bring out peripheral vasodilation, promotes the blood circulation of skin surface and assist diaphoresis.
2, the antipyretic experiment of endotoxin infusion method: the Ramulus Cinnamomi quintessence oil in described volatile oil compositions, ginger essential oil all have refrigeration function; Wherein, the antipyretic response of Ramulus Cinnamomi quintessence oil is obviously better than ginger essential oil; After the composite ginger essential oil of Ramulus Cinnamomi quintessence oil, antipyretic response obviously strengthens, show that the antipyretic response of ginger essential oil to Ramulus Cinnamomi quintessence oil has obvious chemiluminescence, its result is consistent with the result that above-mentioned diaphoresis is tested, all different relevant from both diaphoresis, antipyretic mechanism.
3, Pelvetia siliquosa Tseng et C. F. Chang injection antiinflammatory experiment (taking swelling as index): the Fructus Xanthii quintessence oil in described volatile oil compositions, Radix Angelicae Dahuricae quintessence oil all have the effect alleviating swelling; The alleviate successful of Fructus Xanthii quintessence oil to swelling is better than Radix Angelicae Dahuricae quintessence oil.
4, dimethylbenzene injection antiinflammatory experiment (taking capillary permeability as index): the Fructus Xanthii quintessence oil in described volatile oil compositions, Radix Angelicae Dahuricae quintessence oil all have the effect alleviating capillary permeability; The alleviate successful of Radix Angelicae Dahuricae quintessence oil to capillary permeability is better than Fructus Xanthii quintessence oil.
The principle of above-mentioned pharmacological evaluation and method etc., be the known technology of this area, for brevity, no longer repeat at this.
Clinical verification: adopt paper handkerchief prepared by described volatile oil compositions, show through 300 routine common cold initial stage patient clinical result on trial: its aversion to cold to patient, heating paresthesia remission rate are 73%, be 92% to remission rates such as nasal obstruction, watery nasal discharge, sneezes, total effective rate is 95%.
Animal experiment confirms: the paper handkerchief adopting described volatile oil compositions to prepare is non-stimulated to intact skin, can not cause skin allergic reaction.
Detailed description of the invention
Embodiment 1
The preparation method of described volatile oil compositions: under normal temperature condition, Ramulus Cinnamomi quintessence oil 5 kilograms, ginger essential oil 5 kilograms, Fructus Xanthii quintessence oil 3 kilograms, Radix Angelicae Dahuricae quintessence oil 2 kilograms, benzyl alcohol 5 kilograms, dehydrated alcohol 80 kilograms are placed in the agitated kettle of this area routine use, stir 10 ~ 15 minutes (speed of agitator is 100 ~ 200 revs/min), fill, sealing.
Embodiment 2
The preparation method of described speciality paper handkerchief: tissue post-treatment process known in the art cut front operation section, adopt spraying apparatus well known in the art and discharge rate adjusting process, described spray is sprayed on the relative middle part of paper handkerchief tissue used, then cut, 2 layers of overlapping, banding, folding, pack.The spray dosage of described volatile oil compositions is 0.01% of paper handkerchief tissue weight used.
Embodiment 3
The preparation method of described speciality paper handkerchief: tissue post-treatment process known in the art cut front operation section, adopt spraying apparatus well known in the art and discharge rate adjusting process, described spray is sprayed on the relative middle part of paper handkerchief tissue used, then cut, 3 layers of overlapping, banding cotton ginning, folding, pack.The spray dosage of described volatile oil compositions is 0.02% of paper handkerchief tissue weight used.
For spraying apparatus well known in the art and discharge rate adjusting process etc., for brevity, no longer repeat at this.
Claims (4)
1. the speciality paper handkerchief that is suitable for of common cold initial stage patient, described speciality paper handkerchief is sprayed with a kind of volatile oil compositions, and the formula of described volatile oil compositions is as follows: 1) Ramulus Cinnamomi quintessence oil, 5%; 2) ginger essential oil, 5%; 3) Fructus Xanthii quintessence oil, 3%; 4) Radix Angelicae Dahuricae quintessence oil, 2%; 5) benzyl alcohol, 5%; 8) dehydrated alcohol, adds to 100%; Percentage ratio wherein all refers to percentage by weight.
2. volatile oil compositions according to claim 1, is characterized in that it is a kind of colourless transparent liquid, has strong characteristic aromatic odor, and its static saturated vapor pressure at 25 DEG C is 6.8 ± 0.3kPa.
3. the preparation of the speciality paper handkerchief according to claim 1-2, it is characterized in that preparation method is: tissue post-treatment process known in the art cut front operation section, adopt spraying apparatus well known in the art and discharge rate adjusting process, described volatile oil compositions is sprayed on any position of paper handkerchief tissue used, then cut, with the mode overlapping of 2 layers or 3 layers, envelope pressure or envelope pressure rolling flower, fold, pack.
4. the preparation of speciality paper handkerchief according to claim 3, is characterized in that the spray dosage of described volatile oil compositions is 0.01 ~ 0.02% of paper handkerchief tissue weight used.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410846919.2A CN104524519A (en) | 2014-12-31 | 2014-12-31 | Special handkerchief paper suitable for patient suffering cold in the bud |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410846919.2A CN104524519A (en) | 2014-12-31 | 2014-12-31 | Special handkerchief paper suitable for patient suffering cold in the bud |
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| CN104524519A true CN104524519A (en) | 2015-04-22 |
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| Application Number | Title | Priority Date | Filing Date |
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| CN201410846919.2A Pending CN104524519A (en) | 2014-12-31 | 2014-12-31 | Special handkerchief paper suitable for patient suffering cold in the bud |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104586691A (en) * | 2014-12-31 | 2015-05-06 | 福建恒安集团有限公司 | Aromatic essential oil spray and application thereof in preparation of special paper handkerchief |
| CN116617349A (en) * | 2023-06-01 | 2023-08-22 | 云南省中医医院(云南中医药大学第一附属医院) | Traditional Chinese medicine compound composition for allergic rhinitis |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1083145A (en) * | 1993-05-10 | 1994-03-02 | 广州兴华制药厂 | A kind of property of medicine hygenic towelette and manufacturing technique thereof |
| CN1084373A (en) * | 1993-08-13 | 1994-03-30 | 王见 | Cold-proof beauty handkerchief |
| CN1742752A (en) * | 2005-10-08 | 2006-03-08 | 晏四平 | Atomizing agent containing medicinal plant oil |
-
2014
- 2014-12-31 CN CN201410846919.2A patent/CN104524519A/en active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1083145A (en) * | 1993-05-10 | 1994-03-02 | 广州兴华制药厂 | A kind of property of medicine hygenic towelette and manufacturing technique thereof |
| CN1084373A (en) * | 1993-08-13 | 1994-03-30 | 王见 | Cold-proof beauty handkerchief |
| CN1742752A (en) * | 2005-10-08 | 2006-03-08 | 晏四平 | Atomizing agent containing medicinal plant oil |
Non-Patent Citations (1)
| Title |
|---|
| 张延模: "《中药学》", 31 January 2008, 高等教育出版社 * |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104586691A (en) * | 2014-12-31 | 2015-05-06 | 福建恒安集团有限公司 | Aromatic essential oil spray and application thereof in preparation of special paper handkerchief |
| CN116617349A (en) * | 2023-06-01 | 2023-08-22 | 云南省中医医院(云南中医药大学第一附属医院) | Traditional Chinese medicine compound composition for allergic rhinitis |
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Application publication date: 20150422 |