CN104524218A - Preparation method for nursing infilling for cervical laceration - Google Patents
Preparation method for nursing infilling for cervical laceration Download PDFInfo
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- CN104524218A CN104524218A CN201510000463.2A CN201510000463A CN104524218A CN 104524218 A CN104524218 A CN 104524218A CN 201510000463 A CN201510000463 A CN 201510000463A CN 104524218 A CN104524218 A CN 104524218A
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Abstract
The invention discloses a preparation method for nursing infilling for cervical laceration. The nursing infilling aims to achieve the purpose of treating cervical ectropion after a tooth extraction operation. The preparation method is characterized by comprising the steps that 1, volatile oil is extracted from coarse powder of carex baccans, Sargassum thunbergii (Mert.) O.Kuntze, fragrant sarcococca herb, longleaf bastardtoadflax herb and motherwort fruits, and herb residues are reserved for standby application; 2, lycopodium and eggshell are crushed into fine powder for standby application; 3, herb of denseflower bulbophyllum, radix ranunculi ternati, asparaguns fern, cicer arietinum and the herb residues in the step 1 are evenly mixed, and water is added to the mixture and decocted two times, wherein the amount of water is 3 times that of the mixture, and each time of decocting costs 0.5 hour; decoction solutions are combined and subjected to standing, after filtration, filtrates are obtained, after concentration, the filtrates are subjected to spray drying, and primary materials are obtained; 4, the volatile oil is sprayed into the primary materials, the fine powder of lycopodium and eggshell are added to the primary materials and evenly mixed, the mixture is screened by a 60-mesh sieve, and then sterilization and split charging are carried out. Clinical experiments prove that the nursing infilling has the advantages of being good in curative effect and high in safety when being used for preventing and treating cervicitis, and worth of clinical application and popularization.
Description
Technical field
The present invention relates to the field of Chinese medicines, be specifically related to a kind of preparation method of the nursing implant for laceration of cervix.
Background technology
Parturient laceration of cervix is a kind of common primipara's vaginal delivery soft birth canal injury, and its incidence rate is only second to injury of perineum, is divided into vertical shape laceration and annular laceration with its damage type.The processing scheme of parturient laceration of cervix is: the row of length >1cm sews up process, and gives anti-inflammatory treatment puerperal.The parturient laceration of cervix patient of 14 ~ 25% there will be cervical ectropion clinically, its reason occurred is form more solid fibrous scar after the healing of neck tube mucosa after laceration of cervix, cervical orifice is caused to relax, normal infection causes edema, congested cervix uteri becomes large, plump, and endocervix is given prominence to and formed endocorvix outside cervical canal and turn up.Cervical ectropion once be formed, then can cause protracted course of disease or what chronic cervicitis disease of doing repeatedly, as lax in cervical orifice serious, very then causes in utero or pelvic inflammation.Therefore, after how reducing parturient laceration of cervix, cervical ectropion incidence rate evaluates an index of parturient laceration of cervix long-term prognosis.
At present, the Chinese medicine for parturient laceration of cervix is to control inflammation substantially, Promotive union, and drug application mostly is heat-clearing and toxic substances removing, activating blood and removing stasis drug, but in fact long-term prognosis is bad, can not effectively reduce cervical ectropion incidence rate.
Summary of the invention
Technical assignment of the present invention is for above the deficiencies in the prior art, provides a kind of curative effect certainly and the preparation method of the little nursing implant for laceration of cervix of side effect.
The technical scheme that the present invention solves its technical problem is: a kind of medicine that can improve parturient laceration of cervix long-term prognosis, it is characterized in that being prepared from by the crude drug of following weight proportion: Herba Bulbophylli Odoratissim 10 ~ 30 parts, alizarin 6 ~ 12 parts of sea, Radix Ranunculi Ternati 3 ~ 6 parts, Carex baccans Nees 15 ~ 30 parts, Semen Ciceris Arietini 20 ~ 40 parts, Fructus Leonuri 6 ~ 12 parts, Herba Asparagi Setacei 6 ~ 12 parts, Ovum Gallus domesticus crusta 3 ~ 10 parts, Sarcococca ruscifolia Stapf 6 ~ 9 parts, Spora Lycopodii 6 ~ 12 parts, winebibber's grass 1 ~ 5 part.
Chinese medicine of the present invention can be prepared from by following method:
(1) Carex baccans Nees, Hai Qian, Sarcococca ruscifolia Stapf, Jiu Xiancao, Fructus Leonuri coarse powder are extracted volatile oil, medicinal residues are retained for subsequent use;
(2) Spora Lycopodii, Ovum Gallus domesticus crusta are ground into fine powder, cross 150 mesh sieves, for subsequent use;
(3) the medicinal residues mixing in Herba Bulbophylli Odoratissim, Radix Ranunculi Ternati, Herba Asparagi Setacei, Semen Ciceris Arietini and step 1 is added 3 times of water yields, decoct with water 2 times, each 0.5 hour, collecting decoction, leave standstill 10min; Filter, get filtrate, spraying dry after concentrated, obtain just material;
(4) gained volatile oil in step 1 is sprayed into during step 3 gained just expects, add gained fine powder mixing in step 2, cross 100 mesh sieves, sterilizing subpackage.
Wherein said: Herba Bulbophylli Odoratissim is the orchid family Bulbophyllum platymiscium extremely fragrant Bulbophyllum Bulbophyllum odoratissimum (Swartz) Lindl., with all herbal medicine.Nature and flavor are sweet; Light; Cool.Return lung; Liver; Kidney channel.Merit can moistening the lung and resolving phlegm; Removing obstruction in the collateral to relieve pain.Hai Qian is Sargassaceae plant Alga Sgrgassi Enerves Sargassum enerve C.Ag., Sargassum henslowianum Sargassum henslowianum C.Ag., sargassum thunbergii Sargassum thunbergii(Mert.) O.Kuntze or Sargassum phyllocystum Tseng et Lu,Sargassum horneri (Turn.) C. Ag. (Fucus horneri (Turn.)C.Ag.,Spongocarpus horneri Kutz.) argassum horneri(Turn.) frond of C. Ag.Nature and flavor are salty; Cold.Return liver; Stomach; Kidney channel.Merit can hard masses softening and resolving; Removing heat-phlegm.Radix Ranunculi Ternati is the dried root of ranunculaceae plant Seynuns Kugelann Ranunculus ternatus Thunb..Nature and flavor sweet, acrid, warm.Return liver, lung meridian.Merit can eliminating stagnation, detumescence.Carex baccans Nees is Cyperaceae carex Carex baccans Nees Carex baccans Nees seed.Property sweet, pungent, flat.Merit can rash cough-relieving, invigorating middle warmer diuretic.Semen Ciceris Arietini is the seed of leguminous plant chickpea Cicer arietinum L.Nature and flavor are sweet; Flat; Nontoxic.Return lung; Stomach warp.Merit can heat-clearing and toxic substances removing.Fructus Leonuri is the dry mature fruit of labiate Herba Leonuri Leonurus japonicus Houtt..Nature and flavor are pungent, bitter, are slightly cold.GUIXIN bag, Liver Channel.Merit can promoting blood flow to regulate menstruation, liver heat removing and eyesight improving.Herba Asparagi Setacei is Liliaceae Herba Asparagi Setacei Asparagus setaceus (Kunth) Jessop [A. plumosus Baker] tuber.Sweet, the micro-hardship of nature and flavor, flat.Merit can nourishing the lung to arrest cough.Ovum Gallus domesticus crusta is the hard coat of the ovum of Phasianidae animal man chicken Gallus gallus domesticus Brisson.Nature and flavor are lightly seasoned; Property is put down.Return stomach; Kidney channel.Merit can restrain; Antacid; Bone strengthening; Hemostasis; Improving eyesight.Sarcococca ruscifolia Stapf is Buxaceae Sarcococca plant open country fan flower Sarcococca ruscifolia Stapf root.Nature and flavor are pungent, bitter, flat.Merit can regulating QI to relieve pain, dispelling, collateral-activating.Spora Lycopodii is lycopsid Lycopodium clavatum copodium japonicum Thunb., Herba Lycopodii Obscuri Lycopodium clavatum Lycopodium centro-chinense Ching, Spora Lycopodii Palhinhaea cernua(L.) spore of Franco et Vasc. and single fringe Lycopodium clavatum Lycopodium cernuum L..Nature and flavor are bitter; Temperature.Return liver; Spleen channel.Merit can removing dampness; Sore; Cough-relieving.Winebibber's grass, for Santalaceae plant comes into leaves Herba Thesii Thesium longifolium Turcaz., dew post Herba Thesii Thesium himalense Royle, the herb of Thesium longifolium Hand.-Mazz. Thesium longiflorum Hand.-Mazz. or Thesium refractum C. A. Meyer Thesium refractum C.A.Mey. or root.Nature and flavor are pungent; Micro-hardship; Cool in nature.Return lung; Liver; Spleen channel.Merit can be induced sweat heat clearing away; Expelling wind and relieving convulsion.
Composition principle: parturient laceration of cervix patient 14 ~ 25% there will be cervical ectropion in various degree, conventional antibiotic infection, or add and carry out partner treatment with heat-clearing and toxic substances removing, activating blood and removing stasis drug, puerperal infection probability can be reduced, its incidence rate can not be reduced.Cervical ectropion be formed at inner membrance mucosa under the propagation of excessive fibroblast and capillary endothelial cell, granulation hyperplasia, and the mucosa then occurred.Inventor is clinical experience gained for many years, and the differentiation that laceration of cervix causes cervical ectropion is stayed poly-not loose relevant with body fluid, and its Crack cause mostly is accumulation of phlegm retardance, and in network, QI and blood is not all right, and glue work is for suffering from, and now cervix uteri becomes large, plump then, and fibroid hypertrophy is solid.Therefore it is treated, and should eliminate the phlegm, eliminating stagnation, dredging collateral are gone forward side by side, the rear cervical ectropion incidence rate of parturient laceration of cervix healing can be reduced.
Compared with prior art, the present invention has following characteristics:
1, dispelling local expectorant coagulates for core, therefore with Herba Bulbophylli Odoratissim, Hai Qian for monarch, described Herba Bulbophylli Odoratissim can eleminating phlegm and freeing channels pain relieving, extra large alizarin hard masses softening and resolving, experiment confirms, heavy dose of Herba Bulbophylli Odoratissim has the effect preventing minimizing wound surface from oozing out, madder then can prevent local immunity too drastic in topical application sea, reduces plasma plasminogen expression.Rat deep II degree burn wound wound surface topical application mixing water decoct (Herba Bulbophylli Odoratissim: Hai Qian=2:1) 1.5g(crude drug)/ml soak, its Wound fibroblasts density (NA) value is only 38.34% of model group;
2, get Radix Ranunculi Ternati eliminating stagnation, Semen Ciceris Arietini heat-clearing and toxic substances removing, increase the capable loose effect of monarch drug, Fructus Leonuri is invigorated blood circulation motionless blood, and Carex baccans Nees has and draws effect that all medicines enter skin, can reduce wound surface simultaneously and ooze out;
3, get the gentle gas alleviation Herba Bulbophylli Odoratissim of Herba Asparagi Setacei, sea is alizarin dry strong; And in Semen Ciceris Arietini 44.89 ~ 52.80% starch, the adequate proteins of 18.4 ~ 29.8%, 4.6 ~ 6.10% fatty oils, and the mineral of 2.36 ~ 4.67%, containing several amino acids, trace element and crude fibre in Herba Asparagi Setacei, above-mentioned substance has good facilitation for the local route repair of mucosa; Especially the phosphatidylcholine component contained in Semen Ciceris Arietini, has protective effect for cervical mucosa;
4, get Ovum Gallus domesticus crusta, Spora Lycopodii is used for filling cervix uteri, prevent the undue hydrops because cervix uteri autocrine liquid too much causes, destroy corrupt condition, isolation environmental stimuli;
5, the liposoluble constituent in Sarcococca ruscifolia Stapf has the effect of promotion Transdermal absorption, and its Transdermal absorption effect can not produce pessimal stimulation to cervical mucosal; Low dose of winebibber's grass local is stationed to use slight anesthetic action;
6, contain much starch in Semen Ciceris Arietini, Carex baccans Nees, Herba Asparagi Setacei, the local excitation of medicine can be reduced;
7, in prescription each medicine all without suckling taboo, patient's cervix uteri place filling acceptance good.
Detailed description of the invention
Below in conjunction with practical situation, the specific embodiment of the present invention is elaborated.
Embodiment 1, crude drug weight proportion: Herba Bulbophylli Odoratissim 20 parts, alizarin 10 parts of sea, Radix Ranunculi Ternati 3 parts, Carex baccans Nees 20 parts, Semen Ciceris Arietini 30 parts, Fructus Leonuri 10 parts, Herba Asparagi Setacei 10 parts, Ovum Gallus domesticus crusta 6 parts, Sarcococca ruscifolia Stapf 6 parts, Spora Lycopodii 10 parts, winebibber's grass 2 parts.
The preparation method of embodiment 1 is: Herba Bulbophylli Odoratissim, Hai Qian, Radix Ranunculi Ternati, Herba Asparagi Setacei, Ovum Gallus domesticus crusta, Sarcococca ruscifolia Stapf (under rear), Fructus Leonuri, Semen Ciceris Arietini, Jiu Xiancao, Carex baccans Nees mixing and water adding are decocted, filtrate is got after 30 minutes, medicinal residues add water continue decoction get filtrate after 20 minutes, twice filtrate merges, it is 1.30 that continuation heating is concentrated into relative density, add lycopodium powder, after stirring, sterilizing subpackage.During use, after fully dipping in above-mentioned mastic with aseptic cotton yarn, fill in cervix uteri.
Embodiment 2, crude drug weight proportion: Herba Bulbophylli Odoratissim 10 parts, alizarin 6 parts of sea, Radix Ranunculi Ternati 3 parts, Carex baccans Nees 15 parts, Fructus Leonuri 6 parts, Semen Ciceris Arietini 20 parts, Herba Asparagi Setacei 6 parts, Ovum Gallus domesticus crusta 3 parts, Sarcococca ruscifolia Stapf 6 parts, Spora Lycopodii 6 parts, winebibber's grass 1 part.
Embodiment 3, crude drug weight proportion: Herba Bulbophylli Odoratissim 20 parts, alizarin 10 parts of sea, Radix Ranunculi Ternati 3 parts, Carex baccans Nees 20 parts, Semen Ciceris Arietini 30 parts, Fructus Leonuri 10 parts, Herba Asparagi Setacei 10 parts, Ovum Gallus domesticus crusta 6 parts, Sarcococca ruscifolia Stapf 6 parts, Spora Lycopodii 10 parts, winebibber's grass 2 parts.
Embodiment 4, crude drug weight proportion: Herba Bulbophylli Odoratissim 30 parts, alizarin 12 parts of sea, Radix Ranunculi Ternati 6 parts, Carex baccans Nees 30 parts, Fructus Leonuri 12 parts, Semen Ciceris Arietini 40 parts, Herba Asparagi Setacei 12 parts, Ovum Gallus domesticus crusta 10 parts, Sarcococca ruscifolia Stapf 9 parts, Spora Lycopodii 12 parts, winebibber's grass 5 parts.
The Chinese medicine of embodiment 2 ~ 4 can be prepared from by following method:
(1) Carex baccans Nees, Hai Qian, Sarcococca ruscifolia Stapf, Jiu Xiancao, Fructus Leonuri coarse powder are extracted volatile oil, medicinal residues are retained for subsequent use;
(2) Spora Lycopodii, Ovum Gallus domesticus crusta are ground into fine powder, cross 150 mesh sieves, for subsequent use;
(3) the medicinal residues mixing in Herba Bulbophylli Odoratissim, Radix Ranunculi Ternati, Herba Asparagi Setacei, Semen Ciceris Arietini and step 1 is added 3 times of water yields, decoct with water 2 times, each 0.5 hour, collecting decoction, leave standstill 10min; Filter, get filtrate, spraying dry after concentrated, obtain just material;
(4) gained volatile oil in step 1 is sprayed into during step 3 gained just expects, add gained fine powder mixing in step 2, cross 100 mesh sieves, sterilizing subpackage.
200 mesh sieves were filtered in above-mentioned steps 3.
The efficient combination of said medicine, coordinates mutually, eliminates the phlegm, eliminating stagnation, dredging collateral, effectively reach the object of preventing and treating cervical ectropion after laceration of cervix, and side effect is less.The above results is clinical data sufficient proof, and interrelated data is as follows.
1 object and method.
1.1 object.
1.1.1 case selection: puerpera 100 example of parturient laceration of cervix occurs in August, 2011 ~ vaginal delivery in August, 2014,20 ~ 38 years old age, 28.2 years old mean age.Wherein multipara 19 example, primipara 81 example.
1.1.2 divide into groups: be divided into matched group 34 example at random, clear paste group 33 example, powder group 33 example.Three groups of patients compare in age, parity, delivery time, laceration of cervix situation, and no significant difference (P>0.05), has comparability.
1.1.3 exclusion standard: 1. occur together disease of immune system; 2. scar diathesis.
1.2 method.
1.2.1 Therapeutic Method: matched group patient as laceration of cervix length <1cm, and takes conventional vaginal delivery postpartum care without obviously hemorrhage, and the row as length >1cm sews up process, and gives anti-inflammatory treatment puerperal.On matched group process basis, start after 24 hours from childbirth, after clear paste group fully dips in the mastic of gained in embodiment 1 with aseptic cotton yarn, be pressed in cervix uteri wound place, take out after 30min; Powder group adopts embodiment 3 gained Chinese medicinal powder, after aseptic cotton yarn of sterilizing dips Chinese medicinal powder, is pressed in cervix uteri wound place, takes out after 30min.Clear paste group and powder group are treated once a day, continuous 7 days.
1.2.2 puerperal infection incidence rate: diagnosis basis is from " obstetrics and gynecology ".
1.2.3 cervical ectropion incidence rate: a situation arises to record postoperative cervical ectropion when point 2 months puerperiums check.
1.2.4 statistical analysis: SPSS 13.0 carries out statistical analysis.Measurement data t checks, enumeration data χ
2inspection.
2 results.
2.1 3 groups of puerperal infection are compared: three groups of puerperal infection incidence rates are respectively: matched group 2.94%(1/34); Clear paste group 3.03%(1/33); Powder group 3.03%(1/33).Three groups are compared, and no significant difference (P>0.05), proved invention prescription can not increase puerperal infection probability thus.
After 2.2 three components childbirth property lacerations of cervix, cervical ectropion incidence rate compares: after parturient laceration of cervix in February, the cervical ectropion incidence rate of matched group is 26.47%(9/34); Clear paste group cervical ectropion incidence rate is 6.06%(2/33); The cervical ectropion incidence rate of powder group is 3.03%(1/33).Three groups are compared, and the incidence rate of clear paste group and powder group is starkly lower than matched group (χ
2=5.08, P<0.05; χ
2=7.24, P<0.01), the effect that after proved invention prescription effectively can play the parturient laceration of cervix of reduction thus, cervical ectropion occurs.
2.3 3 groups of adverse reactions of patients incidence rates compare: three groups all do not occur the untoward reaction that medicine is relevant.
3. conclusion.
This result of study shows, use clear paste group of the present invention and powder group effectively can reduce cervical ectropion incidence rate after parturient laceration of cervix, and and without obvious adverse reaction, do not increase puerperal infection probability, illustrate that pharmaceutical composition prepared by the inventive method has the advantage that untoward reaction is comparatively light, safety is higher after reducing parturient laceration of cervix in cervical ectropion incidence rate.
Claims (1)
1., for a preparation method for the nursing implant of laceration of cervix, it is characterized in that, be made up of following steps:
(1) Carex baccans Nees, Hai Qian, Sarcococca ruscifolia Stapf, Jiu Xiancao, Fructus Leonuri coarse powder are extracted volatile oil, medicinal residues are retained for subsequent use;
(2) Spora Lycopodii, Ovum Gallus domesticus crusta are ground into fine powder, cross 150 mesh sieves, for subsequent use;
(3) the medicinal residues mixing in Herba Bulbophylli Odoratissim, Radix Ranunculi Ternati, Herba Asparagi Setacei, Semen Ciceris Arietini and step 1 is added 3 times of water yields, decoct with water 2 times, each 0.5 hour, collecting decoction, leave standstill; Filter, get filtrate, spraying dry after concentrated, obtain just material;
(4) gained volatile oil in step 1 is sprayed into during step 3 gained just expects, add gained fine powder mixing in step 2, sterilizing subpackage.
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| CN201510000463.2A CN104524218A (en) | 2015-01-04 | 2015-01-04 | Preparation method for nursing infilling for cervical laceration |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105412640A (en) * | 2015-12-02 | 2016-03-23 | 张云 | Medicine composition for treating cervical ectropion and preparing method thereof |
| CN105998779A (en) * | 2016-05-31 | 2016-10-12 | 涂雪松 | Preparation method of vagina filling medicine applied after natural delivery |
| CN106389898A (en) * | 2016-05-31 | 2017-02-15 | 胡利霞 | External medicine for promoting vagina recovery after normal delivery |
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| CN1324658A (en) * | 2000-05-23 | 2001-12-05 | 广州暨南大学医药生物技术研究开发中心 | Vagina spray with repair function |
| JP2007278750A (en) * | 2006-04-04 | 2007-10-25 | Ono Pharmaceut Co Ltd | Quantitative analysis of prostaglandins and analog thereof |
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| CN1324658A (en) * | 2000-05-23 | 2001-12-05 | 广州暨南大学医药生物技术研究开发中心 | Vagina spray with repair function |
| JP2007278750A (en) * | 2006-04-04 | 2007-10-25 | Ono Pharmaceut Co Ltd | Quantitative analysis of prostaglandins and analog thereof |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105412640A (en) * | 2015-12-02 | 2016-03-23 | 张云 | Medicine composition for treating cervical ectropion and preparing method thereof |
| CN105998779A (en) * | 2016-05-31 | 2016-10-12 | 涂雪松 | Preparation method of vagina filling medicine applied after natural delivery |
| CN106389898A (en) * | 2016-05-31 | 2017-02-15 | 胡利霞 | External medicine for promoting vagina recovery after normal delivery |
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